| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4018 | 40.9627 | 10.1647 | There is a single DNAmethionine codon-initiated open reading frame of 1,458 nt in frame with a homeobox and a CAX repeat , and the open reading frame is predicted to encode a protein of 51,659 daltons. |
| 2.1632 | 30.9109 | 10.1215 | There is a single methionine codon-initiated open reading frame of 1,458 nt in frame with a homeobox and a CAX repeat , and the DNAopen reading frame is predicted to encode a protein of 51,659 daltons. |
| 0.8242 | 1.0000 | 1.0000 | There is a single methionine codon-initiated open reading frame of 1,458 nt in frame with a DNAhomeobox and a CAX repeat , and the open reading frame is predicted to encode a protein of 51,659 daltons. |
| 0.6974 | 0.9971 | 1.0000 | There is a single methionine codon-initiated open reading frame of 1,458 nt in frame with a homeobox and a DNACAX repeat , and the open reading frame is predicted to encode a protein of 51,659 daltons. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9248 | 1.0000 | 1.0000 | When the homeodomain from DNAHB24 was compared to known mammalian and Drosophila homeodomains it was found to be only moderately conserved, but when it was compared to a highly diverged Drosophila homeodomain , H2.0, it was found to be 80% identical. |
| 1.5614 | 10.5099 | 1.0000 | When the homeodomain from HB24 was compared to known mammalian and Drosophila homeodomains it was found to be only moderately conserved, but when it was compared to a highly diverged proteinDrosophila homeodomain , H2.0, it was found to be 80% identical. |
| 1.3126 | 20.0225 | 1.0000 | When the proteinhomeodomain from HB24 was compared to known mammalian and Drosophila homeodomains it was found to be only moderately conserved, but when it was compared to a highly diverged Drosophila homeodomain , H2.0, it was found to be 80% identical. |
| 0.8890 | 1.0000 | 1.0000 | When the homeodomain from HB24 was compared to known mammalian and Drosophila homeodomains it was found to be only moderately conserved, but when it was compared to a highly diverged Drosophila proteinhomeodomain , H2.0, it was found to be 80% identical. |
| When the homeodomain from HB24 was compared to known mammalian and Drosophila homeodomains it was found to be only moderately conserved, but when it was compared to a highly diverged Drosophila DNAhomeodomain , H2.0, it was found to be 80% identical. | |||
| When the DNAhomeodomain from HB24 was compared to known mammalian and Drosophila homeodomains it was found to be only moderately conserved, but when it was compared to a highly diverged Drosophila homeodomain , H2.0, it was found to be 80% identical. | |||
| When the homeodomain from HB24 was compared to known mammalian and Drosophila homeodomains it was found to be only moderately conserved, but when it was compared to a highly diverged DNADrosophila homeodomain , H2.0, it was found to be 80% identical. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6931 | 20.5372 | 1.0000 | The HB24 mRNA was absent or present at low levels in normal B and T lymphocytes ; however, with the appropriate activation signal RNAHB24 mRNA was induced within several hours even in the presence of cycloheximide . |
| 1.8103 | 10.7270 | 1.0000 | The RNAHB24 mRNA was absent or present at low levels in normal B and T lymphocytes ; however, with the appropriate activation signal HB24 mRNA was induced within several hours even in the presence of cycloheximide . |
| 2.0372 | 20.7163 | 0.9932 | The HB24 mRNA was absent or present at low levels in normal B and T lymphocytes ; however, with the appropriate activation signal DNAHB24 mRNA was induced within several hours even in the presence of cycloheximide . |
| 1.5236 | 10.8909 | 0.9863 | The DNAHB24 mRNA was absent or present at low levels in normal B and T lymphocytes ; however, with the appropriate activation signal HB24 mRNA was induced within several hours even in the presence of cycloheximide . |
| The HB24 mRNA was absent or present at low levels in normal B and cell_typeT lymphocytes ; however, with the appropriate activation signal HB24 mRNA was induced within several hours even in the presence of cycloheximide . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7200 | 10.8804 | 1.0000 | Characterization of DNAHB24 expression in lymphoid and select developing tissues was performed by in situ hybridization . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7672 | 10.0935 | 1.0000 | HB24 is likely to have an important role in cell_typelymphocytes as well as in certain developing tissues . |
| 0.9486 | 1.0000 | 1.0000 | DNAHB24 is likely to have an important role in lymphocytes as well as in certain developing tissues . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0552 | 30.3046 | 10.9835 | Platelet-activating factor induces phospholipid turnover , calcium flux , arachidonic acid liberation , eicosanoid generation , and oncogene expression in a cell_linehuman B cell line . |
| 0.9013 | 0.9998 | 1.0000 | proteinPlatelet-activating factor induces phospholipid turnover , calcium flux , arachidonic acid liberation , eicosanoid generation , and oncogene expression in a human B cell line . |
| Platelet-activating factor induces phospholipid turnover , calcium flux , arachidonic acid liberation , eicosanoid generation , and DNAoncogene expression in a human B cell line . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8916 | 0.9999 | 0.9999 | proteinPlatelet-activating factor is a potent mediator of the inflammatory response . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0820 | 20.7758 | 1.0000 | Studies of the actions of proteinplatelet-activating factor have centered mainly around neutrophils , monocytes , and platelets . |
| 1.6166 | 10.9218 | 0.9999 | Studies of the actions of platelet-activating factor have centered mainly around neutrophils , monocytes , and cell_typeplatelets . |
| 1.5320 | 10.7247 | 1.0000 | Studies of the actions of platelet-activating factor have centered mainly around cell_typeneutrophils , monocytes , and platelets . |
| 0.9047 | 1.0000 | 1.0000 | Studies of the actions of platelet-activating factor have centered mainly around neutrophils , cell_typemonocytes , and platelets . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1855 | 20.6277 | 0.9999 | In this report we begin to uncover the influence of proteinplatelet-activating factor on B lymphocytes . |
| 1.4720 | 10.8983 | 0.9997 | In this report we begin to uncover the influence of platelet-activating factor on cell_typeB lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8101 | 20.6781 | 20.3450 | Employing the cell_lineEBV-transformed human B cell line SKW6.4 , we demonstrate that platelet-activating factor significantly alters membrane phospholipid metabolism indicated by the incorporation of 32P into phosphatidylcholine , phosphatidylinositol , and phosphatidic acid but not significantly into phosphatidylethanolamine at concentrations ranging from 10(-9) to 10(-6) M. |
| 2.2562 | 20.4319 | 1.0000 | Employing the EBV-transformed human B cell line SKW6.4 , we demonstrate that proteinplatelet-activating factor significantly alters membrane phospholipid metabolism indicated by the incorporation of 32P into phosphatidylcholine , phosphatidylinositol , and phosphatidic acid but not significantly into phosphatidylethanolamine at concentrations ranging from 10(-9) to 10(-6) M. |
| 0.9459 | 0.9984 | 0.9999 | Employing the EBV-transformed human B cell line cell_lineSKW6.4 , we demonstrate that platelet-activating factor significantly alters membrane phospholipid metabolism indicated by the incorporation of 32P into phosphatidylcholine , phosphatidylinositol , and phosphatidic acid but not significantly into phosphatidylethanolamine at concentrations ranging from 10(-9) to 10(-6) M. |
| 2.6040 | 20.7617 | 20.3573 | Employing the cell_lineEBV-transformed human B cell line SKW6.4 , we demonstrate that platelet-activating factor significantly alters membrane phospholipid metabolism indicated by the incorporation of 32P into phosphatidylcholine , phosphatidylinositol , and phosphatidic acid but not significantly into phosphatidylethanolamine at concentrations ranging from 10(-9) to 10(-6) M. |
| Employing the EBV-transformed cell_linehuman B cell line SKW6.4 , we demonstrate that platelet-activating factor significantly alters membrane phospholipid metabolism indicated by the incorporation of 32P into phosphatidylcholine , phosphatidylinositol , and phosphatidic acid but not significantly into phosphatidylethanolamine at concentrations ranging from 10(-9) to 10(-6) M. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7255 | 10.7714 | 1.0000 | The inactive precursor, proteinlyso-platelet-activating factor , at a concentration as high as 10(-7) M had no effect on any of the membrane phospholipids . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3857 | 20.4854 | 1.0000 | We also show that proteinplatelet-activating factor from 10(-12) to 10(-6) M induced rapid and significant elevation in intracellular calcium levels , whereas lyso- platelet-activating factor was again ineffective. |
| 1.3485 | 20.2716 | 10.1085 | We also show that platelet-activating factor from 10(-12) to 10(-6) M induced rapid and significant elevation in intracellular calcium levels , whereas lyso- proteinplatelet-activating factor was again ineffective. |
| 2.3881 | 20.5147 | 10.6097 | We also show that platelet-activating factor from 10(-12) to 10(-6) M induced rapid and significant elevation in intracellular calcium levels , whereas proteinlyso- platelet-activating factor was again ineffective. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3281 | 20.3536 | 1.0000 | We further demonstrate the impact of proteinplatelet-activating factor binding to B cells by measuring platelet-activating factor induced arachidonic acid release and 5-hydroxyeicosatetraenoic acid production. |
| 1.6211 | 10.9622 | 1.0000 | We further demonstrate the impact of platelet-activating factor binding to B cells by measuring proteinplatelet-activating factor induced arachidonic acid release and 5-hydroxyeicosatetraenoic acid production. |
| 1.5653 | 10.9136 | 0.9999 | We further demonstrate the impact of platelet-activating factor binding to cell_typeB cells by measuring platelet-activating factor induced arachidonic acid release and 5-hydroxyeicosatetraenoic acid production. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0642 | 20.0928 | 0.9991 | Moreover, platelet-activating factor was capable of inducing transcription of the DNAnuclear proto-oncogenes c-fos and c-jun . |
| 1.5120 | 10.0648 | 0.9999 | Moreover, proteinplatelet-activating factor was capable of inducing transcription of the nuclear proto-oncogenes c-fos and c-jun . |
| 0.9378 | 1.0000 | 1.0000 | Moreover, platelet-activating factor was capable of inducing transcription of the nuclear proto-oncogenes DNAc-fos and c-jun . |
| 0.9343 | 1.0000 | 1.0000 | Moreover, platelet-activating factor was capable of inducing transcription of the nuclear proto-oncogenes c-fos and DNAc-jun . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3805 | 20.3991 | 1.0000 | Finally we explored the possible role of 5-hydroxyeicosatetraenoic acid as a regulator of arachidonic acid liberation demonstrating that endogenous 5-lipoxygenase activity modulates platelet-activating factor induced arachidonic acid release perhaps acting at the level of proteinphospholipase A2 . |
| 1.6588 | 10.7170 | 1.0000 | Finally we explored the possible role of 5-hydroxyeicosatetraenoic acid as a regulator of arachidonic acid liberation demonstrating that endogenous 5-lipoxygenase activity modulates proteinplatelet-activating factor induced arachidonic acid release perhaps acting at the level of phospholipase A2 . |
| 0.9639 | 1.0000 | 1.0000 | Finally we explored the possible role of 5-hydroxyeicosatetraenoic acid as a regulator of arachidonic acid liberation demonstrating that endogenous protein5-lipoxygenase activity modulates platelet-activating factor induced arachidonic acid release perhaps acting at the level of phospholipase A2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9790 | 20.9323 | 10.9186 | In summary, platelet-activating factor is shown here to have a direct and profound effect on a cell_linepure B cell line . |
| 1.4388 | 20.7154 | 1.0000 | In summary, proteinplatelet-activating factor is shown here to have a direct and profound effect on a pure B cell line . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6305 | 20.3866 | 10.8206 | Positive and negative regulation of immunoglobulin gene expression by a novel DNAB-cell-specific enhancer element . |
| 2.0649 | 20.1787 | 0.9999 | Positive and negative regulation of DNAimmunoglobulin gene expression by a novel B-cell-specific enhancer element . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.4193 | 30.2162 | 10.9242 | A new B-cell-specific enhancer element has been identified 3' of E4 and the octamerlike motifs in the DNAhuman immunoglobulin heavy-chain gene enhancer . |
| 3.3985 | 20.4050 | 10.6894 | A new DNAB-cell-specific enhancer element has been identified 3' of E4 and the octamerlike motifs in the human immunoglobulin heavy-chain gene enhancer . |
| 1.1691 | 10.6093 | 0.9998 | A new B-cell-specific enhancer element has been identified 3' of E4 and the DNAoctamerlike motifs in the human immunoglobulin heavy-chain gene enhancer . |
| 0.8504 | 0.9999 | 1.0000 | A new B-cell-specific enhancer element has been identified 3' of DNAE4 and the octamerlike motifs in the human immunoglobulin heavy-chain gene enhancer . |
| A new B-cell-specific enhancer element has been identified 3' of E4 and the octamerlike motifs in the proteinhuman immunoglobulin heavy-chain gene enhancer . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1641 | 20.7167 | 10.8267 | Tandem copies of this 67-bp MnlI-AluI fragment , when fused to the chloramphenicol acetyltransferase gene driven by the conalbumin promoter , stimulated transcription in B cells but not in cell_lineJurkat T cells or HeLa cells . |
| 3.8577 | 20.8639 | 10.3298 | Tandem copies of this DNA67-bp MnlI-AluI fragment , when fused to the chloramphenicol acetyltransferase gene driven by the conalbumin promoter , stimulated transcription in B cells but not in Jurkat T cells or HeLa cells . |
| 2.8969 | 20.8240 | 10.1505 | Tandem copies of this 67-bp MnlI-AluI fragment , when fused to the DNAchloramphenicol acetyltransferase gene driven by the conalbumin promoter , stimulated transcription in B cells but not in Jurkat T cells or HeLa cells . |
| 2.1089 | 20.1042 | 0.9999 | Tandem copies of this 67-bp MnlI-AluI fragment , when fused to the chloramphenicol acetyltransferase gene driven by the conalbumin promoter , stimulated transcription in cell_typeB cells but not in Jurkat T cells or HeLa cells . |
| 2.0627 | 20.0917 | 0.9999 | Tandem copies of this 67-bp MnlI-AluI fragment , when fused to the chloramphenicol acetyltransferase gene driven by the DNAconalbumin promoter , stimulated transcription in B cells but not in Jurkat T cells or HeLa cells . |
| 1.5175 | 10.3723 | 0.9992 | Tandem copies of this 67-bp MnlI-AluI fragment , when fused to the chloramphenicol acetyltransferase gene driven by the conalbumin promoter , stimulated transcription in B cells but not in Jurkat T cells or cell_lineHeLa cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2404 | 20.0671 | 0.9999 | Footprinting analysis revealed that the identical sequence CCGAAACTGAAAAGG , designated E6 , was protected by nuclear extracts from cell_typeB cells , T cells , or HeLa cells. |
| 1.7514 | 10.2843 | 1.0000 | Footprinting analysis revealed that the identical sequence CCGAAACTGAAAAGG , designated DNAE6 , was protected by nuclear extracts from B cells , T cells , or HeLa cells. |
| 1.6300 | 10.4547 | 0.9999 | Footprinting analysis revealed that the identical sequence CCGAAACTGAAAAGG , designated E6 , was protected by nuclear extracts from B cells , cell_typeT cells , or HeLa cells. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5181 | 10.7551 | 0.9994 | Gel mobility shift assays using a synthetic E6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in T cells and cell_lineHeLa cells . |
| 1.4252 | 10.8544 | 0.9999 | Gel mobility shift assays using a synthetic E6 motif detected a proteinB-cell-specific complex in addition to a ubiquitous band found also in T cells and HeLa cells . |
| 1.3975 | 10.7839 | 0.9998 | Gel mobility shift assays using a synthetic E6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in cell_typeT cells and HeLa cells . |
| 2.1061 | 20.1133 | 1.0000 | Gel mobility shift assays using a synthetic E6 motif detected a B-cell-specific complex in addition to a proteinubiquitous band found also in T cells and HeLa cells . |
| 2.0576 | 20.0127 | 0.9999 | Gel mobility shift assays using a synthetic DNAE6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in T cells and HeLa cells . |
| 1.6682 | 10.1110 | 0.9684 | Gel mobility shift assays using a synthetic DNAE6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in T cells and HeLa cells . |
| Gel mobility shift assays using a DNAsynthetic E6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in T cells and HeLa cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3041 | 20.8358 | 1.0000 | In agreement with the results of gel retardation assays , tandem copies of the DNAE6 motif stimulated transcription in ARH77 and Raji cells but not in Jurkat or HeLa cells . |
| 1.7933 | 10.0771 | 1.0000 | In agreement with the results of gel retardation assays , tandem copies of the E6 motif stimulated transcription in cell_lineARH77 and Raji cells but not in Jurkat or HeLa cells . |
| 1.7176 | 10.1674 | 1.0000 | In agreement with the results of gel retardation assays , tandem copies of the E6 motif stimulated transcription in ARH77 and Raji cells but not in cell_lineJurkat or HeLa cells . |
| 1.5696 | 10.1995 | 0.9999 | In agreement with the results of gel retardation assays , tandem copies of the E6 motif stimulated transcription in ARH77 and cell_lineRaji cells but not in Jurkat or HeLa cells . |
| 1.5349 | 10.4348 | 0.9996 | In agreement with the results of gel retardation assays , tandem copies of the E6 motif stimulated transcription in ARH77 and Raji cells but not in Jurkat or cell_lineHeLa cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1151 | 20.2880 | 10.5402 | Furthermore, a DNAmutant E6 motif lost both in vitro binding activity and in vivo enhancer activity . |
| 0.6869 | 0.9995 | 0.9997 | Furthermore, a mutant DNAE6 motif lost both in vitro binding activity and in vivo enhancer activity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9701 | 20.9424 | 10.9337 | In striking contrast to the DNAmouse Ig heavy-chain enhancer , in which the octamer motif acts as a B-cell-specific enhancer element , the human enhancer contains an octamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own. |
| 3.5042 | 20.7802 | 10.4745 | In striking contrast to the mouse Ig heavy-chain enhancer , in which the octamer motif acts as a DNAB-cell-specific enhancer element , the human enhancer contains an octamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own. |
| 2.2313 | 20.6892 | 1.0000 | In striking contrast to the mouse Ig heavy-chain enhancer , in which the octamer motif acts as a B-cell-specific enhancer element , the human enhancer contains an octamerlike sequence with one base substitution which bound proteinoctamer-binding proteins with only very low affinity and showed no enhancer activity of its own. |
| 2.1503 | 20.3578 | 0.9999 | In striking contrast to the mouse Ig heavy-chain enhancer , in which the octamer motif acts as a B-cell-specific enhancer element , the DNAhuman enhancer contains an octamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own. |
| 2.1204 | 20.0778 | 0.9999 | In striking contrast to the mouse Ig heavy-chain enhancer , in which the DNAoctamer motif acts as a B-cell-specific enhancer element , the human enhancer contains an octamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own. |
| 2.0856 | 20.3407 | 0.9999 | In striking contrast to the mouse Ig heavy-chain enhancer , in which the octamer motif acts as a B-cell-specific enhancer element , the human enhancer contains an DNAoctamerlike sequence with one base substitution which bound octamer-binding proteins with only very low affinity and showed no enhancer activity of its own. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6132 | 10.0453 | 1.0000 | Interestingly, the MnlI-AluI fragment could suppress the basal-level activity of the conalbumin promoter in both cell_lineJurkat and HeLa cells . |
| 1.4704 | 10.6531 | 0.9999 | Interestingly, the DNAMnlI-AluI fragment could suppress the basal-level activity of the conalbumin promoter in both Jurkat and HeLa cells . |
| 1.4387 | 10.9265 | 0.9999 | Interestingly, the MnlI-AluI fragment could suppress the basal-level activity of the DNAconalbumin promoter in both Jurkat and HeLa cells . |
| 0.7627 | 0.9984 | 0.9997 | Interestingly, the MnlI-AluI fragment could suppress the basal-level activity of the conalbumin promoter in both Jurkat and cell_lineHeLa cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0553 | 20.8319 | 0.9999 | Moreover, simian virus 40 enhancer activity was blocked by the DNAMnlI-AluI fragment in HeLa cells but not in B cells . |
| 2.0359 | 20.7502 | 0.9996 | Moreover, simian virus 40 enhancer activity was blocked by the MnlI-AluI fragment in HeLa cells but not in cell_typeB cells . |
| 1.4160 | 10.9928 | 0.9999 | Moreover, simian virus 40 enhancer activity was blocked by the MnlI-AluI fragment in cell_lineHeLa cells but not in B cells . |
| 2.9631 | 10.6893 | 10.1382 | Moreover, DNAsimian virus 40 enhancer activity was blocked by the MnlI-AluI fragment in HeLa cells but not in B cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8439 | 0.9989 | 0.9999 | Thus, the novel enhancer element identified in this study is probably a target site for both positive and proteinnegative factors . |
| 0.5514 | 1.0000 | 0.9990 | Thus, the novel enhancer element identified in this study is probably a target site for both proteinpositive and negative factors . |
| 4.4559 | 20.2425 | 10.7260 | Thus, the DNAnovel enhancer element identified in this study is probably a target site for both positive and negative factors . |
| 1.2473 | 10.4496 | 0.9999 | Thus, the novel enhancer element identified in this study is probably a DNAtarget site for both positive and negative factors . |
| Thus, the novel enhancer element identified in this study is probably a target site for both proteinpositive and negative factors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5881 | 20.6576 | 1.0000 | The involvement of proteinion channels in B and T lymphocyte activation is supported by many reports of changes in ion fluxes and membrane potential after mitogen binding . |
| 1.8043 | 10.3166 | 1.0000 | The involvement of ion channels in B and T lymphocyte activation is supported by many reports of changes in ion fluxes and membrane potential after proteinmitogen binding . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0565 | 20.6297 | 10.9221 | We have used charybdotoxin , a known inhibitor of proteinCa(2+)-dependent K+ channels , to study the role of these channels in lymphocyte activation and mitogenesis . |
| 0.9360 | 1.0000 | 1.0000 | We have used charybdotoxin , a known inhibitor of Ca(2+)-dependent K+ channels , to study the role of these channels in cell_typelymphocyte activation and mitogenesis . |
| 0.5143 | 0.9998 | 0.9998 | We have used charybdotoxin , a known inhibitor of Ca(2+)-dependent proteinK+ channels , to study the role of these channels in lymphocyte activation and mitogenesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9717 | 20.6648 | 10.8402 | However, blockade of the proteinCa(2+)-activated K+ channel is not associated with changes in cell-cycle gene activation , IL-2 production , IL-2R expression or B and T cell mitogenesis . |
| 1.7298 | 10.2450 | 1.0000 | However, blockade of the Ca(2+)-activated K+ channel is not associated with changes in cell-cycle gene activation , IL-2 production , proteinIL-2R expression or B and T cell mitogenesis . |
| 1.7295 | 10.0805 | 1.0000 | However, blockade of the Ca(2+)-activated K+ channel is not associated with changes in cell-cycle gene activation , proteinIL-2 production , IL-2R expression or B and T cell mitogenesis . |
| 1.5317 | 10.9471 | 0.9999 | However, blockade of the Ca(2+)-activated K+ channel is not associated with changes in DNAcell-cycle gene activation , IL-2 production , IL-2R expression or B and T cell mitogenesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1495 | 20.8902 | 10.8269 | These results imply that membrane potential changes secondary to the ligand-dependent opening of proteinCa(2+)-activated K+ channels are not involved in B and T lymphocyte activation and mitogenesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3454 | 20.3701 | 10.9900 | Activity of the kappa B enhancer of the proteininterleukin-2 receptor alpha chain in somatic cell hybrids is accompanied by the nuclear localization of NF-kappa B . |
| 3.9286 | 20.6014 | 10.9218 | Activity of the DNAkappa B enhancer of the interleukin-2 receptor alpha chain in somatic cell hybrids is accompanied by the nuclear localization of NF-kappa B . |
| 2.9113 | 20.4841 | 10.8978 | Activity of the kappa B enhancer of the interleukin-2 receptor alpha chain in cell_linesomatic cell hybrids is accompanied by the nuclear localization of NF-kappa B . |
| 2.0324 | 20.1674 | 0.9999 | Activity of the kappa B enhancer of the interleukin-2 receptor alpha chain in somatic cell hybrids is accompanied by the nuclear localization of proteinNF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0141 | 20.5160 | 1.0000 | The two nuclear proteins NF-kappa B (consisting of subunits p50 an dp65 ) and the proteinDNA-binding subunit of NF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5 . |
| 1.6254 | 10.0588 | 1.0000 | The two nuclear proteins NF-kappa B (consisting of subunits p50 an dp65 ) and the DNA-binding subunit of NF-kappa B ( p50 ) by itself, also called proteinKBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5 . |
| 1.5381 | 10.5478 | 1.0000 | The two nuclear proteins NF-kappa B (consisting of subunits p50 an dp65 ) and the DNA-binding subunit of proteinNF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5 . |
| 0.9774 | 1.0000 | 1.0000 | The two nuclear proteins NF-kappa B (consisting of subunits p50 an dp65 ) and the DNA-binding subunit of NF-kappa B ( proteinp50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5 . |
| 0.9497 | 1.0000 | 1.0000 | The two nuclear proteins NF-kappa B (consisting of subunits p50 an proteindp65 ) and the DNA-binding subunit of NF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5 . |
| 0.9369 | 1.0000 | 1.0000 | The two nuclear proteins NF-kappa B (consisting of subunits proteinp50 an dp65 ) and the DNA-binding subunit of NF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5 . |
| 0.8768 | 0.9969 | 1.0000 | The two nuclear proteins proteinNF-kappa B (consisting of subunits p50 an dp65 ) and the DNA-binding subunit of NF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5 . |
| 5.6613 | 30.9199 | 20.7959 | The two nuclear proteins NF-kappa B (consisting of subunits p50 an dp65 ) and the DNA-binding subunit of NF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the cell_linehuman T-cell line IARC 301.5 . |
| 1.9614 | 20.2304 | 0.9994 | The two proteinnuclear proteins NF-kappa B (consisting of subunits p50 an dp65 ) and the DNA-binding subunit of NF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5 . |
| The two nuclear proteins NF-kappa B (consisting of subunits p50 an dp65 ) and the DNA-binding subunit of NF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line cell_lineIARC 301.5 . | |||
| The proteintwo nuclear proteins NF-kappa B (consisting of subunits p50 an dp65 ) and the DNA-binding subunit of NF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the human T-cell line IARC 301.5 . | |||
| The two nuclear proteins NF-kappa B (consisting of subunits p50 an dp65 ) and the DNA-binding subunit of NF-kappa B ( p50 ) by itself, also called KBF1 , are constitutively expressed and localized in the nucleus of the cell_linehuman T-cell line IARC 301.5 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6644 | 20.8165 | 10.5870 | In order to define the roles of these two factors , which bind to the same DNAkappa B enhancers , in transcription activation we have prepared somatic cell hybrids between IARC 301.5 and a murine myeloma . |
| 1.6590 | 10.5823 | 0.9999 | In order to define the roles of these two factors , which bind to the same kappa B enhancers , in transcription activation we have prepared somatic cell hybrids between cell_lineIARC 301.5 and a murine myeloma . |
| 1.4189 | 10.9365 | 0.9997 | In order to define the roles of these two factors , which bind to the same kappa B enhancers , in transcription activation we have prepared somatic cell hybrids between IARC 301.5 and a cell_linemurine myeloma . |
| 4.3361 | 20.6421 | 10.7641 | In order to define the roles of these two factors , which bind to the same kappa B enhancers , in transcription activation we have prepared cell_linesomatic cell hybrids between IARC 301.5 and a murine myeloma . |
| In order to define the roles of these two proteinfactors , which bind to the same kappa B enhancers , in transcription activation we have prepared somatic cell hybrids between IARC 301.5 and a murine myeloma . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5792 | 10.7516 | 1.0000 | Most hybrids express both KBF1 and proteinNF-kappa B in their nuclei , but one hybrid expresses only KBF1 . |
| 1.5412 | 10.9372 | 1.0000 | Most hybrids express both proteinKBF1 and NF-kappa B in their nuclei , but one hybrid expresses only KBF1 . |
| 1.5262 | 10.4149 | 1.0000 | Most hybrids express both KBF1 and NF-kappa B in their nuclei , but one hybrid expresses only proteinKBF1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.3663 | 30.7892 | 20.0404 | The kappa B enhancer of the gene encoding the proteininterleukin-2 ( IL-2 ) receptor alpha chain ( IL-2R alpha ) is functional only in the hybrids expressing nuclear NF-kappa B . |
| 2.2151 | 20.3732 | 10.1657 | The kappa B enhancer of the gene encoding the interleukin-2 ( IL-2 ) receptor alpha chain ( IL-2R alpha ) is functional only in the hybrids expressing nuclear proteinNF-kappa B . |
| 1.6433 | 20.2076 | 10.9503 | The kappa B enhancer of the gene encoding the interleukin-2 ( IL-2 ) receptor alpha chain ( IL-2R alpha ) is functional only in the hybrids expressing proteinnuclear NF-kappa B . |
| 1.2714 | 20.8065 | 0.9973 | The kappa B enhancer of the gene encoding the proteininterleukin-2 ( IL-2 ) receptor alpha chain ( IL-2R alpha ) is functional only in the hybrids expressing nuclear NF-kappa B . |
| 0.9490 | 1.0000 | 0.9985 | The kappa B enhancer of the gene encoding the interleukin-2 ( proteinIL-2 ) receptor alpha chain ( IL-2R alpha ) is functional only in the hybrids expressing nuclear NF-kappa B . |
| 0.8293 | 0.9991 | 0.9999 | The kappa B enhancer of the gene encoding the interleukin-2 ( IL-2 ) receptor alpha chain ( proteinIL-2R alpha ) is functional only in the hybrids expressing nuclear NF-kappa B . |
| 0.6237 | 0.8573 | 0.9981 | The DNAkappa B enhancer of the gene encoding the interleukin-2 ( IL-2 ) receptor alpha chain ( IL-2R alpha ) is functional only in the hybrids expressing nuclear NF-kappa B . |
| The kappa B enhancer of the gene encoding the interleukin-2 ( IL-2 ) receptor alpha chain ( IL-2R alpha ) is functional only in the cell_linehybrids expressing nuclear NF-kappa B . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5425 | 20.7521 | 10.5903 | These findings show that proteinnuclear NF-kappa B is necessary to activate the kappa B enhancer , while KBF1 by itself is not sufficient. |
| 3.4647 | 20.8856 | 10.4393 | These findings show that nuclear NF-kappa B is necessary to activate the DNAkappa B enhancer , while KBF1 by itself is not sufficient. |
| 2.3849 | 20.8598 | 0.9996 | These findings show that nuclear NF-kappa B is necessary to activate the kappa B enhancer , while proteinKBF1 by itself is not sufficient. |
| 0.7161 | 0.9999 | 0.9999 | These findings show that nuclear proteinNF-kappa B is necessary to activate the kappa B enhancer , while KBF1 by itself is not sufficient. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4365 | 20.1210 | 1.0000 | We propose that KBF1 is a competitive inhibitor of proteinNF-kappa B and discuss how these factors may be involved in the transient expression of IL-2 and IL-2 alpha genes during the immune response . |
| 1.7433 | 10.2468 | 1.0000 | We propose that proteinKBF1 is a competitive inhibitor of NF-kappa B and discuss how these factors may be involved in the transient expression of IL-2 and IL-2 alpha genes during the immune response . |
| 0.7006 | 0.9999 | 0.9998 | We propose that KBF1 is a competitive inhibitor of NF-kappa B and discuss how these factors may be involved in the transient expression of proteinIL-2 and IL-2 alpha genes during the immune response . |
| 0.6308 | 1.0000 | 0.9983 | We propose that KBF1 is a competitive inhibitor of NF-kappa B and discuss how these factors may be involved in the transient expression of IL-2 and proteinIL-2 alpha genes during the immune response . |
| We propose that KBF1 is a competitive inhibitor of NF-kappa B and discuss how these factors may be involved in the transient expression of IL-2 and proteinIL-2 alpha genes during the immune response . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7545 | 20.5265 | 10.4528 | T-helper-cell determinants in protein antigens are preferentially located in proteincysteine-rich antigen segments resistant to proteolytic cleavage by cathepsin B , L , and D . |
| 1.5343 | 10.9344 | 1.0000 | T-helper-cell determinants in proteinprotein antigens are preferentially located in cysteine-rich antigen segments resistant to proteolytic cleavage by cathepsin B , L , and D . |
| 0.8437 | 0.9976 | 0.9999 | proteinT-helper-cell determinants in protein antigens are preferentially located in cysteine-rich antigen segments resistant to proteolytic cleavage by cathepsin B , L , and D . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1220 | 20.5020 | 1.0000 | We report on a computer algorithm capable of predicting the location of proteinT-helper-cell epitopes in protein antigen ( Ag ) by analysing the Ag amino acid sequence . |
| 1.4816 | 10.5702 | 1.0000 | We report on a computer algorithm capable of predicting the location of T-helper-cell epitopes in proteinprotein antigen ( Ag ) by analysing the Ag amino acid sequence . |
| 0.9515 | 1.0000 | 1.0000 | We report on a computer algorithm capable of predicting the location of T-helper-cell epitopes in protein antigen ( proteinAg ) by analysing the Ag amino acid sequence . |
| 4.7213 | 20.9204 | 10.6753 | We report on a computer algorithm capable of predicting the location of T-helper-cell epitopes in protein antigen ( Ag ) by analysing the proteinAg amino acid sequence . |
| We report on a computer algorithm capable of predicting the location of T-helper-cell epitopes in protein antigen ( Ag ) by analysing the proteinAg amino acid sequence . | |||
| We report on a computer algorithm capable of predicting the location of T-helper-cell epitopes in protein antigen ( Ag ) by analysing the Ag proteinamino acid sequence . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7992 | 10.5069 | 1.0000 | The algorithm was constructed with the aim of identifying segments in proteinAg which are resistant to proteolytic degradation by the enzymes cathepsin B , L , and D . |
| 0.8080 | 1.0000 | 1.0000 | The algorithm was constructed with the aim of identifying segments in Ag which are resistant to proteolytic degradation by the enzymes cathepsin B , proteinL , and D . |
| 0.7677 | 0.9997 | 1.0000 | The algorithm was constructed with the aim of identifying segments in Ag which are resistant to proteolytic degradation by the enzymes proteincathepsin B , L , and D . |
| 0.5358 | 1.0000 | 1.0000 | The algorithm was constructed with the aim of identifying segments in Ag which are resistant to proteolytic degradation by the enzymes cathepsin B , L , and proteinD . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6144 | 20.9491 | 10.9457 | These are prominent enzymes in the endocytic pathway through which proteinsoluble protein Ag enter APC , and resistant segments in Ag may, therefore, be expected to contain more T-cell determinants than susceptible segments . |
| 2.2377 | 20.4366 | 1.0000 | These are prominent enzymes in the endocytic pathway through which soluble protein Ag enter APC , and resistant segments in Ag may, therefore, be expected to contain more proteinT-cell determinants than susceptible segments . |
| 1.7265 | 10.7647 | 1.0000 | These are prominent enzymes in the endocytic pathway through which soluble protein Ag enter APC , and resistant segments in proteinAg may, therefore, be expected to contain more T-cell determinants than susceptible segments . |
| 1.5026 | 10.8748 | 0.9998 | These are prominent enzymes in the endocytic pathway through which soluble protein Ag enter APC , and resistant segments in Ag may, therefore, be expected to contain more T-cell determinants than proteinsusceptible segments . |
| 1.1514 | 10.7908 | 0.9999 | These are prominent enzymes in the endocytic pathway through which soluble protein Ag enter APC , and proteinresistant segments in Ag may, therefore, be expected to contain more T-cell determinants than susceptible segments . |
| 0.5894 | 1.0000 | 1.0000 | These are prominent proteinenzymes in the endocytic pathway through which soluble protein Ag enter APC , and resistant segments in Ag may, therefore, be expected to contain more T-cell determinants than susceptible segments . |
| 0.5252 | 1.0000 | 1.0000 | These are prominent enzymes in the endocytic pathway through which soluble protein proteinAg enter APC , and resistant segments in Ag may, therefore, be expected to contain more T-cell determinants than susceptible segments . |
| 0.8789 | 0.9999 | 1.0000 | These are prominent enzymes in the endocytic pathway through which soluble protein Ag enter cell_typeAPC , and resistant segments in Ag may, therefore, be expected to contain more T-cell determinants than susceptible segments . |
| These are prominent enzymes in the endocytic pathway through which soluble protein Ag enter proteinAPC , and resistant segments in Ag may, therefore, be expected to contain more T-cell determinants than susceptible segments . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6901 | 10.8332 | 0.9999 | From information available in the literature on the substrate specificity of the three enzymes , it is clear that a cysteine is not accepted in any of the S2 , S1 , S1' , and S2' subsites of cathepsin B and L , and not in the S1 and S1' subsites of proteincathepsin D . |
| 0.9394 | 1.0000 | 1.0000 | From information available in the literature on the substrate specificity of the three proteinenzymes , it is clear that a cysteine is not accepted in any of the S2 , S1 , S1' , and S2' subsites of cathepsin B and L , and not in the S1 and S1' subsites of cathepsin D . |
| 0.7582 | 1.0000 | 1.0000 | From information available in the literature on the substrate specificity of the three enzymes , it is clear that a cysteine is not accepted in any of the S2 , S1 , S1' , and S2' subsites of cathepsin B and L , and not in the proteinS1 and S1' subsites of cathepsin D . |
| 1.6677 | 10.0937 | 0.9999 | From information available in the literature on the substrate specificity of the three enzymes , it is clear that a cysteine is not accepted in any of the S2 , S1 , S1' , and S2' subsites of proteincathepsin B and L , and not in the S1 and S1' subsites of cathepsin D . |
| From information available in the literature on the substrate specificity of the three enzymes , it is clear that a cysteine is not accepted in any of the S2 , S1 , S1' , and S2' subsites of cathepsin B and L , and not in the S1 and proteinS1' subsites of cathepsin D . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8580 | 30.2826 | 10.3868 | Moreover, we have noticed that proteincysteine -containing T-cell determinants in a number of protein Ag are particularly rich in the amino acids alanine , glycine , lysine , leucine , serine , threonine , and valine . |
| 2.2800 | 20.8083 | 1.0000 | Moreover, we have noticed that cysteine -containing T-cell determinants in a number of proteinprotein Ag are particularly rich in the amino acids alanine , glycine , lysine , leucine , serine , threonine , and valine . |
| Moreover, we have noticed that cysteine -containing T-cell determinants in a number of protein proteinAg are particularly rich in the amino acids alanine , glycine , lysine , leucine , serine , threonine , and valine . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5348 | 20.5375 | 1.0000 | By searching protein Ag for clusters of amino acids containing cysteine and two of the other amino acids we were able to predict 17 out of 23 empirically known proteinT-cell determinants in the Ag with a relatively low number of false (positive) predictions. |
| 0.9489 | 1.0000 | 1.0000 | By searching protein Ag for clusters of amino acids containing cysteine and two of the other amino acids we were able to predict 17 out of 23 empirically known T-cell determinants in the proteinAg with a relatively low number of false (positive) predictions. |
| 2.5525 | 20.6343 | 1.0000 | By searching proteinprotein Ag for clusters of amino acids containing cysteine and two of the other amino acids we were able to predict 17 out of 23 empirically known T-cell determinants in the Ag with a relatively low number of false (positive) predictions. |
| By searching protein proteinAg for clusters of amino acids containing cysteine and two of the other amino acids we were able to predict 17 out of 23 empirically known T-cell determinants in the Ag with a relatively low number of false (positive) predictions. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6360 | 20.1292 | 10.6717 | Furthermore, we present a new principle for searching Ag for potential proteinamphipatic alpha-helical protein segments . |
| 1.6485 | 10.1346 | 1.0000 | Furthermore, we present a new principle for searching proteinAg for potential amphipatic alpha-helical protein segments . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5343 | 20.1555 | 1.0000 | Such segments accord well with empirically known proteinT-cell determinants and our algorithm produces a lower number of false positive predictions than the principle based on discrete Fourier transformations previously described. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1252 | 10.6109 | 10.6136 | Contribution of NF-kappa B and DNASp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1 : distinct patterns of viral growth are determined by T-cell types . |
| 2.3728 | 20.5677 | 0.9998 | Contribution of NF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1 : distinct patterns of viral growth are determined by cell_typeT-cell types . |
| 1.5325 | 10.9298 | 0.9999 | Contribution of proteinNF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1 : distinct patterns of viral growth are determined by T-cell types . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.8605 | 30.0926 | 10.8935 | Starting with a replication-incompetent molecular clone of human immunodeficiency virus type 1 , lacking all the NF-kappa B and Sp1 binding sites present in the DNAnative long terminal repeat ( LTR ), proviruses containing reconstructed LTRs with individual or combinations of NF-kappa B and Sp1 elements were generated and evaluated for their capacity to produce virus progeny following transfection-cocultivation . |
| 2.2870 | 20.5965 | 1.0000 | Starting with a replication-incompetent molecular clone of human immunodeficiency virus type 1 , lacking all the NF-kappa B and Sp1 binding sites present in the native long terminal repeat ( LTR ), proviruses containing DNAreconstructed LTRs with individual or combinations of NF-kappa B and Sp1 elements were generated and evaluated for their capacity to produce virus progeny following transfection-cocultivation . |
| 0.9655 | 1.0000 | 1.0000 | Starting with a replication-incompetent molecular clone of human immunodeficiency virus type 1 , lacking all the NF-kappa B and Sp1 binding sites present in the native long terminal repeat ( DNALTR ), proviruses containing reconstructed LTRs with individual or combinations of NF-kappa B and Sp1 elements were generated and evaluated for their capacity to produce virus progeny following transfection-cocultivation . |
| 0.9055 | 1.0000 | 1.0000 | Starting with a replication-incompetent molecular clone of human immunodeficiency virus type 1 , lacking all the NF-kappa B and Sp1 binding sites present in the native long terminal repeat ( LTR ), proviruses containing reconstructed DNALTRs with individual or combinations of NF-kappa B and Sp1 elements were generated and evaluated for their capacity to produce virus progeny following transfection-cocultivation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9491 | 20.3796 | 10.8656 | Virus stocks obtained from these experiments exhibited a continuum of replicative capacities in different cell_typehuman T-cell types depending on which element (s) was present in the LTR . |
| 1.7820 | 10.2816 | 1.0000 | Virus stocks obtained from these experiments exhibited a continuum of replicative capacities in different human T-cell types depending on which element (s) was present in the DNALTR . |
| Virus stocks obtained from these experiments exhibited a continuum of replicative capacities in different human T-cell types depending on which DNAelement (s) was present in the LTR . | |||
| Virus stocks obtained from these experiments exhibited a continuum of replicative capacities in different human cell_typeT-cell types depending on which element (s) was present in the LTR . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3830 | 20.7349 | 10.7224 | For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements (and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( cell_typeperipheral blood lymphocytes = MT4 greater than H9 greater than CEM greater than Jurkat ) was observed. |
| 2.9535 | 20.6571 | 10.8608 | For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements (and no DNASp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( peripheral blood lymphocytes = MT4 greater than H9 greater than CEM greater than Jurkat ) was observed. |
| 1.9880 | 20.7182 | 0.7669 | For example, in experiments involving proviral clones with LTRs containing one or two proteinNF-kappa B elements (and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( peripheral blood lymphocytes = MT4 greater than H9 greater than CEM greater than Jurkat ) was observed. |
| 1.8268 | 10.1302 | 1.0000 | For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements (and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( peripheral blood lymphocytes = MT4 greater than cell_lineH9 greater than CEM greater than Jurkat ) was observed. |
| 1.8226 | 10.1418 | 1.0000 | For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements (and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( peripheral blood lymphocytes = MT4 greater than H9 greater than cell_lineCEM greater than Jurkat ) was observed. |
| 1.8163 | 10.2499 | 1.0000 | For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements (and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( peripheral blood lymphocytes = MT4 greater than H9 greater than CEM greater than cell_lineJurkat ) was observed. |
| 1.7400 | 10.3557 | 1.0000 | For example, in experiments involving proviral clones with DNALTRs containing one or two NF-kappa B elements (and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( peripheral blood lymphocytes = MT4 greater than H9 greater than CEM greater than Jurkat ) was observed. |
| 1.4149 | 20.6845 | 0.9999 | For example, in experiments involving proviral clones with LTRs containing one or two DNANF-kappa B elements (and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( peripheral blood lymphocytes = MT4 greater than H9 greater than CEM greater than Jurkat ) was observed. |
| 0.9343 | 1.0000 | 1.0000 | For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements (and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( peripheral blood lymphocytes = cell_lineMT4 greater than H9 greater than CEM greater than Jurkat ) was observed. |
| For example, in experiments involving proviral clones with LTRs containing one or two NF-kappa B elements (and no Sp1 binding sites ), a hierarchy of cellular permissivity to virus replication ( peripheral blood cell_typelymphocytes = MT4 greater than H9 greater than CEM greater than Jurkat ) was observed. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9990 | 20.0141 | 0.9999 | Of note was the associated emergence of second-site LTR revertants which involved an alteration of the DNATATA box . |
| 3.7199 | 20.4942 | 10.8002 | Of note was the associated emergence of DNAsecond-site LTR revertants which involved an alteration of the TATA box . |
| Of note was the associated emergence of DNAsecond-site LTR revertants which involved an alteration of the TATA box . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 8.8649 | 40.1497 | 20.5856 | These results suggest that the DNAhuman immunodeficiency virus type 1 LTR possesses functional redundancy which ensures virus replication in different T-cell types and is capable of changing depending on the particular combination of transcriptional factors present. |
| 2.1114 | 20.6606 | 0.9999 | These results suggest that the human immunodeficiency virus type 1 LTR possesses functional redundancy which ensures virus replication in different cell_typeT-cell types and is capable of changing depending on the particular combination of transcriptional factors present. |
| 1.9425 | 20.7005 | 0.9999 | These results suggest that the human immunodeficiency virus type 1 LTR possesses functional redundancy which ensures virus replication in different T-cell types and is capable of changing depending on the particular combination of proteintranscriptional factors present. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5646 | 20.0541 | 10.7156 | Stimulation of DNAinterferon beta gene transcription in vitro by purified NF-kappa B and a novel TH protein . |
| 1.4846 | 10.7520 | 1.0000 | Stimulation of interferon beta gene transcription in vitro by purified proteinNF-kappa B and a novel TH protein . |
| 1.4278 | 10.7181 | 0.9999 | Stimulation of interferon beta gene transcription in vitro by purified NF-kappa B and a novel proteinTH protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7694 | 20.4815 | 0.9999 | The human interferon beta ( IFN-beta ) regulatory element consists of multiple DNAenhanson domains which are targets for transcription factors involved in inducible expression of the promoter . |
| 1.7590 | 20.3725 | 0.9999 | The human interferon beta ( IFN-beta ) regulatory element consists of multiple enhanson domains which are targets for proteintranscription factors involved in inducible expression of the promoter . |
| 1.6677 | 10.2974 | 0.9320 | The DNAhuman interferon beta ( IFN-beta ) regulatory element consists of multiple enhanson domains which are targets for transcription factors involved in inducible expression of the promoter . |
| 1.3655 | 10.6247 | 0.9999 | The human interferon beta ( IFN-beta ) regulatory element consists of multiple enhanson domains which are targets for transcription factors involved in inducible expression of the DNApromoter . |
| 0.9372 | 1.0000 | 0.9949 | The human interferon beta ( proteinIFN-beta ) regulatory element consists of multiple enhanson domains which are targets for transcription factors involved in inducible expression of the promoter . |
| The proteinhuman interferon beta ( IFN-beta ) regulatory element consists of multiple enhanson domains which are targets for transcription factors involved in inducible expression of the promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.3177 | 30.5651 | 10.8871 | To further characterize the protein-DNA interactions mediating IFN-beta induction , proteinpositive regulatory domain (PRD) II binding proteins were purified from phorbol ester induced Jurkat T-cells and from IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells . |
| 0.7403 | 0.9997 | 1.0000 | To further characterize the protein-DNA interactions mediating proteinIFN-beta induction , positive regulatory domain (PRD) II binding proteins were purified from phorbol ester induced Jurkat T-cells and from IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells . |
| 0.6623 | 0.9904 | 0.9996 | To further characterize the protein-DNA interactions mediating IFN-beta induction , positive regulatory domain (PRD) II binding proteins were purified from phorbol ester induced cell_lineJurkat T-cells and from IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells . |
| 0.6429 | 1.0000 | 0.9998 | To further characterize the protein-DNA interactions mediating IFN-beta induction , positive regulatory domain (PRD) II binding proteins were purified from phorbol ester induced Jurkat T-cells and from proteinIFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells . |
| 4.2181 | 20.6912 | 10.9140 | To further characterize the protein-DNA interactions mediating IFN-beta induction , positive regulatory domain (PRD) II binding proteins were purified from cell_linephorbol ester induced Jurkat T-cells and from IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells . |
| To further characterize the protein-DNA interactions mediating IFN-beta induction , DNApositive regulatory domain (PRD) II binding proteins were purified from phorbol ester induced Jurkat T-cells and from IFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells . | |||
| To further characterize the protein-DNA interactions mediating IFN-beta induction , positive regulatory domain (PRD) II binding proteins were purified from phorbol ester induced Jurkat T-cells and from cell_lineIFN primed, cycloheximide/polyinosinic-polycytidylic acid treated HeLa S3 cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7252 | 10.2908 | 1.0000 | From cell_lineHeLa cells , two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity , whereas from T-cells , four proteins--a major protein of 52 kD and three minor proteins of 82 , 67 , and 43-47 kD --were purified. |
| 1.6700 | 10.1827 | 1.0000 | From HeLa cells , two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity , whereas from T-cells , four proteins--a major protein of protein52 kD and three minor proteins of 82 , 67 , and 43-47 kD --were purified. |
| 1.6672 | 10.2824 | 1.0000 | From HeLa cells , two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity , whereas from cell_typeT-cells , four proteins--a major protein of 52 kD and three minor proteins of 82 , 67 , and 43-47 kD --were purified. |
| 1.6595 | 10.1605 | 0.9999 | From HeLa cells , two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity , whereas from T-cells , four proteins--a proteinmajor protein of 52 kD and three minor proteins of 82 , 67 , and 43-47 kD --were purified. |
| From HeLa cells , two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity , whereas from T-cells , four proteins--a major protein of 52 kD and three proteinminor proteins of 82 , 67 , and 43-47 kD --were purified. | |||
| From HeLa cells , two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity , whereas from T-cells , four proteins--a major protein of 52 kD and three minor proteins of protein82 , 67 , and 43-47 kD --were purified. | |||
| From HeLa cells , two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity , whereas from T-cells , four proteins--a major protein of 52 kD and three minor proteins of 82 , 67 , and protein43-47 kD --were purified. | |||
| From HeLa cells , two major proteins of 52 and 45 kilodaltons (kD) copurified with DNA binding activity , whereas from T-cells , four proteins--a major protein of 52 kD and three minor proteins of 82 , protein67 , and 43-47 kD --were purified. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4660 | 10.9535 | 0.9999 | Also, an induction specific DNA binding protein was purified from cell_lineHeLa cells that interacted with the ( AAGTGA )4 tetrahexamer sequence and the PRDI domain . |
| 5.8393 | 30.0025 | 20.2303 | Also, an induction specific DNA binding protein was purified from HeLa cells that interacted with the protein( AAGTGA )4 tetrahexamer sequence and the PRDI domain . |
| 3.4954 | 20.8589 | 10.8218 | Also, an induction specific proteinDNA binding protein was purified from HeLa cells that interacted with the ( AAGTGA )4 tetrahexamer sequence and the PRDI domain . |
| 1.8409 | 20.3283 | 0.9998 | Also, an induction specific DNA binding protein was purified from HeLa cells that interacted with the ( AAGTGA )4 tetrahexamer sequence and the proteinPRDI domain . |
| 1.1304 | 0.9998 | 10.6269 | Also, an induction specific DNA binding protein was purified from HeLa cells that interacted with the ( proteinAAGTGA )4 tetrahexamer sequence and the PRDI domain . |
| Also, an induction proteinspecific DNA binding protein was purified from HeLa cells that interacted with the ( AAGTGA )4 tetrahexamer sequence and the PRDI domain . | |||
| Also, an induction specific DNA binding protein was purified from HeLa cells that interacted with the ( AAGTGA )4 tetrahexamer sequence and the DNAPRDI domain . | |||
| Also, an induction specific DNA binding protein was purified from HeLa cells that interacted with the ( AAGTGA )4 DNAtetrahexamer sequence and the PRDI domain . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5383 | 10.4945 | 1.0000 | This protein is immunologically distinct from proteinIRF-1/ISGF2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2259 | 20.9733 | 10.0065 | Uninduced or Sendai virus induced HeLa extracts were used to examine transcription in vitro using a series of DNAIFN beta promoter deletions . |
| 2.6203 | 20.7207 | 10.2729 | Uninduced or Sendai virus induced HeLa extracts were used to examine transcription in vitro using a series of DNAIFN beta promoter deletions . |
| 0.7119 | 0.9998 | 0.9974 | Uninduced or Sendai virus induced cell_lineHeLa extracts were used to examine transcription in vitro using a series of IFN beta promoter deletions . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3620 | 20.5727 | 1.0000 | Deletions upstream of the DNAPRDII element increased transcription in the uninduced extract, indicating predominantly negative regulation of the promoter . |
| 1.7494 | 10.7519 | 1.0000 | Deletions upstream of the PRDII element increased transcription in the uninduced extract, indicating predominantly negative regulation of the DNApromoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6382 | 10.9998 | 1.0000 | A 2-4-fold increase in DNAIFN-beta promoter transcription was observed in Sendai virus induced extracts , and deletion of PRDI and PRDII elements decreased this induced level of transcription . |
| 0.7193 | 0.9999 | 1.0000 | A 2-4-fold increase in IFN-beta promoter transcription was observed in Sendai virus induced extracts , and deletion of DNAPRDI and PRDII elements decreased this induced level of transcription . |
| 0.6563 | 0.9999 | 0.9935 | A 2-4-fold increase in IFN-beta promoter transcription was observed in Sendai virus induced extracts , and deletion of PRDI and DNAPRDII elements decreased this induced level of transcription . |
| 0.5930 | 0.9919 | 0.9999 | A 2-4-fold increase in IFN-beta promoter transcription was observed in Sendai virus induced extracts , and deletion of PRDI and DNAPRDII elements decreased this induced level of transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8555 | 20.9296 | 10.4024 | When purified PRDII and proteintetrahexamer binding proteins were added to the induced extract, a 4-fold increase in transcription was observed. |
| 1.5477 | 10.3834 | 10.0044 | When proteinpurified PRDII and tetrahexamer binding proteins were added to the induced extract, a 4-fold increase in transcription was observed. |
| 0.8941 | 0.9999 | 1.0000 | When purified proteinPRDII and tetrahexamer binding proteins were added to the induced extract, a 4-fold increase in transcription was observed. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7751 | 10.2488 | 1.0000 | These experiments demonstrate that it is possible to modulate IFN-beta transcription in vitro but indicate that additional proteins may be required to fully activate proteinIFN-beta transcription . |
| 1.8081 | 10.0104 | 1.0000 | These experiments demonstrate that it is possible to modulate proteinIFN-beta transcription in vitro but indicate that additional proteins may be required to fully activate IFN-beta transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8549 | 20.5001 | 10.6632 | The rhombotin family of DNAcysteine -rich LIM-domain oncogenes : distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 . |
| 1.1761 | 10.8872 | 0.9998 | The proteinrhombotin family of cysteine -rich LIM-domain oncogenes : distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 . |
| 0.9449 | 1.0000 | 1.0000 | The rhombotin family of cysteine -rich LIM-domain oncogenes : distinct members are involved in T-cell translocations to human chromosomes 11p15 and DNA11p13 . |
| 0.7672 | 1.0000 | 1.0000 | The rhombotin family of cysteine -rich LIM-domain oncogenes : distinct members are involved in T-cell translocations to human chromosomes DNA11p15 and 11p13 . |
| The rhombotin family of cysteine -rich LIM-domain oncogenes : distinct members are involved in DNAT-cell translocations to human chromosomes 11p15 and 11p13 . | |||
| The DNArhombotin family of cysteine -rich LIM-domain oncogenes : distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0824 | 10.9433 | 10.9103 | A chromosomal translocation in a T-cell leukemia involving the short arm of DNAhuman chromosome 11 at band 11p15 disrupts the rhombotin gene . |
| 1.6204 | 10.2285 | 0.9999 | A chromosomal translocation in a T-cell leukemia involving the short arm of human chromosome 11 at DNAband 11p15 disrupts the rhombotin gene . |
| 1.4185 | 10.9224 | 0.9998 | A chromosomal translocation in a T-cell leukemia involving the short arm of human chromosome 11 at band 11p15 disrupts the DNArhombotin gene . |
| 1.3032 | 10.5075 | 0.9999 | A chromosomal translocation in a T-cell leukemia involving the DNAshort arm of human chromosome 11 at band 11p15 disrupts the rhombotin gene . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9052 | 10.7388 | 10.6852 | This gene encodes a protein with duplicated proteincysteine -rich regions called LIM domains , which show homology to zinc-binding proteins and to iron-sulfur centers of ferredoxins . |
| 1.4960 | 10.9019 | 1.0000 | This gene encodes a protein with duplicated cysteine -rich regions called LIM domains , which show homology to proteinzinc-binding proteins and to iron-sulfur centers of ferredoxins . |
| 1.4430 | 10.7796 | 1.0000 | This gene encodes a protein with duplicated cysteine -rich regions called LIM domains , which show homology to zinc-binding proteins and to proteiniron-sulfur centers of ferredoxins . |
| 0.8571 | 1.0000 | 1.0000 | This gene encodes a protein with duplicated cysteine -rich regions called LIM domains , which show homology to zinc-binding proteins and to iron-sulfur centers of proteinferredoxins . |
| 0.8181 | 0.9989 | 1.0000 | This gene encodes a protein with duplicated cysteine -rich regions called proteinLIM domains , which show homology to zinc-binding proteins and to iron-sulfur centers of ferredoxins . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2479 | 20.1454 | 1.0000 | Two homologues of the DNArhombotin gene have now been isolated. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6558 | 20.5603 | 10.7778 | One of these, designated Rhom-2 , is located on DNAhuman chromosome 11 at band 11p13 , where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene . |
| 2.3013 | 20.7172 | 0.9999 | One of these, designated Rhom-2 , is located on human chromosome 11 at band 11p13 , where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the DNARhom-2 gene . |
| 1.7868 | 10.2761 | 1.0000 | One of these, designated Rhom-2 , is located on human chromosome 11 at band 11p13 , where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at DNA11p13 are upstream of the Rhom-2 gene . |
| 1.6152 | 10.3789 | 1.0000 | One of these, designated Rhom-2 , is located on human chromosome 11 at DNAband 11p13 , where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene . |
| 0.8860 | 1.0000 | 1.0000 | One of these, designated DNARhom-2 , is located on human chromosome 11 at band 11p13 , where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene . |
| 1.0408 | 10.5719 | 0.9999 | One of these, designated Rhom-2 , is located on human chromosome 11 at band 11p13 , where a cluster of T-cell leukemia-specific translocations occur; all DNAtranslocation breakpoints at 11p13 are upstream of the Rhom-2 gene . |
| One of these, designated Rhom-2 , is located on human chromosome 11 at band 11p13 , where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the DNARhom-2 gene . | |||
| One of these, designated Rhom-2 , is located on human chromosome 11 at band 11p13 , where a cluster of DNAT-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1547 | 20.9397 | 20.4349 | Human and mouse Rhom-2 are highly conserved and, like rhombotin , encode two proteintandem cysteine -rich LIM domains . |
| 1.4530 | 10.2204 | 1.0000 | Human and mouse Rhom-2 are highly conserved and, like proteinrhombotin , encode two tandem cysteine -rich LIM domains . |
| 0.8257 | 1.0000 | 1.0000 | Human and mouse proteinRhom-2 are highly conserved and, like rhombotin , encode two tandem cysteine -rich LIM domains . |
| Human and mouse Rhom-2 are highly conserved and, like rhombotin , encode two tandem cysteine -rich proteinLIM domains . | |||
| Human and mouse Rhom-2 are highly conserved and, like rhombotin , encode two DNAtandem cysteine -rich LIM domains . | |||
| Human and mouse Rhom-2 are highly conserved and, like DNArhombotin , encode two tandem cysteine -rich LIM domains . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9401 | 0.9986 | 1.0000 | RNARhom-2 mRNA is expressed in early mouse development in central nervous system , lung , kidney , liver , and spleen but only very low levels occur in thymus . |
| 0.9272 | 1.0000 | 0.9915 | proteinRhom-2 mRNA is expressed in early mouse development in central nervous system , lung , kidney , liver , and spleen but only very low levels occur in thymus . |
| DNARhom-2 mRNA is expressed in early mouse development in central nervous system , lung , kidney , liver , and spleen but only very low levels occur in thymus . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1159 | 20.9836 | 0.9999 | The other gene, designated Rhom-3 , is not on chromosome 11 but also retains homology to the DNALIM domain of rhombotin . |
| 1.7163 | 10.8771 | 1.0000 | The other gene, designated DNARhom-3 , is not on chromosome 11 but also retains homology to the LIM domain of rhombotin . |
| 2.2959 | 20.6039 | 1.0000 | The other gene, designated Rhom-3 , is not on DNAchromosome 11 but also retains homology to the LIM domain of rhombotin . |
| 1.5959 | 10.2034 | 1.0000 | The other gene, designated Rhom-3 , is not on chromosome 11 but also retains homology to the LIM domain of proteinrhombotin . |
| The other gene, designated Rhom-3 , is not on chromosome 11 but also retains homology to the LIM domain of DNArhombotin . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3893 | 20.2098 | 1.0000 | Since the DNARhom-2 gene is such a common site of chromosomal damage in T-cell tumors , the consistency of translocations near the rhombotin gene was further examined. |
| 2.3350 | 20.6580 | 1.0000 | Since the Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors , the consistency of translocations near the DNArhombotin gene was further examined. |
| 2.0999 | 20.7340 | 0.9881 | Since the Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors , the consistency of translocations near the proteinrhombotin gene was further examined. |
| Since the DNARhom-2 gene is such a common site of chromosomal damage in T-cell tumors , the consistency of translocations near the rhombotin gene was further examined. | |||
| Since the Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors , the consistency of translocations near the DNArhombotin gene was further examined. | |||
| Since the Rhom-2 gene is such a common site of chromosomal damage in cell_typeT-cell tumors , the consistency of translocations near the rhombotin gene was further examined. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6949 | 10.5797 | 1.0000 | A second translocation adjacent to proteinrhombotin was found and at the same position as in the previous example. |
| A second translocation adjacent to DNArhombotin was found and at the same position as in the previous example. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8390 | 10.2425 | 1.0000 | Therefore, chromosome bands 11p15 ( rhombotin ) and DNA11p13 ( Rhom-2 ) are consistent sites of chromosome translocation in T-cell leukemia , with the 11p15 target more rarely involved. |
| 1.6566 | 20.5864 | 1.0000 | Therefore, chromosome bands 11p15 ( rhombotin ) and 11p13 ( Rhom-2 ) are consistent sites of chromosome translocation in T-cell leukemia , with the DNA11p15 target more rarely involved. |
| 0.9340 | 1.0000 | 1.0000 | Therefore, chromosome bands 11p15 ( rhombotin ) and 11p13 ( DNARhom-2 ) are consistent sites of chromosome translocation in T-cell leukemia , with the 11p15 target more rarely involved. |
| 0.9231 | 1.0000 | 1.0000 | Therefore, chromosome bands 11p15 ( DNArhombotin ) and 11p13 ( Rhom-2 ) are consistent sites of chromosome translocation in T-cell leukemia , with the 11p15 target more rarely involved. |
| 2.1800 | 20.6310 | 0.9941 | Therefore, chromosome bands 11p15 ( rhombotin ) and 11p13 ( Rhom-2 ) are consistent sites of chromosome translocation in T-cell leukemia , with the DNA11p15 target more rarely involved. |
| 1.4393 | 10.7966 | 0.9977 | Therefore, DNAchromosome bands 11p15 ( rhombotin ) and 11p13 ( Rhom-2 ) are consistent sites of chromosome translocation in T-cell leukemia , with the 11p15 target more rarely involved. |
| 0.9520 | 0.9999 | 1.0000 | Therefore, chromosome bands DNA11p15 ( rhombotin ) and 11p13 ( Rhom-2 ) are consistent sites of chromosome translocation in T-cell leukemia , with the 11p15 target more rarely involved. |
| Therefore, DNAchromosome bands 11p15 ( rhombotin ) and 11p13 ( Rhom-2 ) are consistent sites of chromosome translocation in T-cell leukemia , with the 11p15 target more rarely involved. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8078 | 10.7910 | 10.4494 | The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated DNAcysteine -rich LIM domains . |
| 1.2878 | 10.9000 | 0.9999 | The results define the rhombotin gene family as a class of DNAT-cell oncogenes with duplicated cysteine -rich LIM domains . |
| 2.8682 | 20.2298 | 10.8491 | The results define the DNArhombotin gene family as a class of T-cell oncogenes with duplicated cysteine -rich LIM domains . |
| 1.1961 | 10.5411 | 0.9931 | The results define the proteinrhombotin gene family as a class of T-cell oncogenes with duplicated cysteine -rich LIM domains . |
| The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine -rich proteinLIM domains . | |||
| The results define the DNArhombotin gene family as a class of T-cell oncogenes with duplicated cysteine -rich LIM domains . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1044 | 30.8309 | 10.9894 | NF-kappa B activation by tumor necrosis factor alpha in the cell_lineJurkat T cell line is independent of protein kinase A , protein kinase C , and Ca(2+) -regulated kinases . |
| 4.1250 | 20.7384 | 10.8227 | NF-kappa B activation by proteintumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A , protein kinase C , and Ca(2+) -regulated kinases . |
| 3.7844 | 20.8491 | 10.9362 | NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of proteinprotein kinase A , protein kinase C , and Ca(2+) -regulated kinases . |
| 3.1867 | 20.7065 | 10.5494 | NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A , protein kinase C , and proteinCa(2+) -regulated kinases . |
| 2.8511 | 10.4917 | 10.2114 | NF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A , proteinprotein kinase C , and Ca(2+) -regulated kinases . |
| 0.8688 | 0.9999 | 1.0000 | proteinNF-kappa B activation by tumor necrosis factor alpha in the Jurkat T cell line is independent of protein kinase A , protein kinase C , and Ca(2+) -regulated kinases . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2643 | 30.4345 | 10.8613 | NF-kappa B is a proteinDNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus ( HIV ) genes . |
| 3.1680 | 30.7083 | 10.8504 | NF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including DNAhuman immunodeficiency virus ( HIV ) genes . |
| 0.8864 | 0.9998 | 1.0000 | proteinNF-kappa B is a DNA-binding regulatory factor able to control transcription of a number of genes, including human immunodeficiency virus ( HIV ) genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2428 | 20.6271 | 10.4982 | In T cells , NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine proteintumor necrosis factor alpha ( TNF alpha ). |
| 2.1930 | 10.9030 | 10.1708 | In cell_typeT cells , NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha ( TNF alpha ). |
| 1.7017 | 10.0101 | 0.9999 | In T cells , NF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha ( proteinTNF alpha ). |
| 1.5068 | 10.7111 | 0.9999 | In T cells , proteinNF-kappa B is activated upon cellular treatment by phorbol esters and the cytokine tumor necrosis factor alpha ( TNF alpha ). |
| 1.2933 | 10.4250 | 0.9996 | In T cells , NF-kappa B is activated upon cellular treatment by phorbol esters and the proteincytokine tumor necrosis factor alpha ( TNF alpha ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8456 | 20.9621 | 10.9019 | In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a cell_linehuman T cell line ( Jurkat ) and its subclone JCT6 , which presents a deficiency in the PKA transduction pathway . |
| 2.2656 | 20.0359 | 1.0000 | In the present work, we investigated the molecular events leading to proteinNF-kappa B activation by TNF alpha in a human T cell line ( Jurkat ) and its subclone JCT6 , which presents a deficiency in the PKA transduction pathway . |
| 1.6678 | 10.5330 | 1.0000 | In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line ( Jurkat ) and its subclone JCT6 , which presents a deficiency in the proteinPKA transduction pathway . |
| 1.4832 | 10.8109 | 1.0000 | In the present work, we investigated the molecular events leading to NF-kappa B activation by proteinTNF alpha in a human T cell line ( Jurkat ) and its subclone JCT6 , which presents a deficiency in the PKA transduction pathway . |
| 0.9735 | 1.0000 | 1.0000 | In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line ( Jurkat ) and its subclone cell_lineJCT6 , which presents a deficiency in the PKA transduction pathway . |
| 0.9417 | 1.0000 | 1.0000 | In the present work, we investigated the molecular events leading to NF-kappa B activation by TNF alpha in a human T cell line ( cell_lineJurkat ) and its subclone JCT6 , which presents a deficiency in the PKA transduction pathway . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2298 | 20.1348 | 0.9999 | We found that in both cell lines, both phorbol ester and TNF alpha were able to activate proteinNF-kappa B . |
| 2.2253 | 20.2848 | 1.0000 | We found that in both cell lines, both phorbol ester and proteinTNF alpha were able to activate NF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6037 | 10.8550 | 1.0000 | Phorbol activation was positively modulated by Ca2+ influx while proteinTNF alpha activation was not. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6786 | 10.4544 | 1.0000 | Furthermore, while PMA activation was inhibited by the proteinPKC inhibitor staurosporin , the TNF alpha effect was unchanged. |
| 1.6129 | 10.7692 | 1.0000 | Furthermore, while PMA activation was inhibited by the PKC inhibitor staurosporin , the proteinTNF alpha effect was unchanged. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9577 | 1.0000 | 1.0000 | proteinTNF alpha did not activate cAMP production and its signal was not modulated by cAMP activators . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5559 | 10.4563 | 0.9997 | Moreover, cAMP activators did not activate NF-kappa B in cell_lineJurkat cells . |
| 1.4921 | 10.6488 | 1.0000 | Moreover, cAMP activators did not activate proteinNF-kappa B in Jurkat cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1292 | 20.3734 | 10.7791 | Thus, TNF alpha -induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as proteinprotein kinase C ( PKC ), protein kinase A , or Ca(2+)-regulated kinases . |
| 2.9100 | 10.9779 | 10.6512 | Thus, TNF alpha -induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C ( PKC ), proteinprotein kinase A , or Ca(2+)-regulated kinases . |
| 2.0203 | 20.2389 | 0.9999 | Thus, TNF alpha -induced NF-kappa B activation was found to be mediated by none of the major proteinsignal-mediating kinases such as protein kinase C ( PKC ), protein kinase A , or Ca(2+)-regulated kinases . |
| 1.9947 | 20.2263 | 0.9998 | Thus, TNF alpha -induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C ( PKC ), protein kinase A , or proteinCa(2+)-regulated kinases . |
| 1.5048 | 10.6093 | 1.0000 | Thus, TNF alpha -induced proteinNF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C ( PKC ), protein kinase A , or Ca(2+)-regulated kinases . |
| 0.9625 | 1.0000 | 1.0000 | Thus, TNF alpha -induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C ( proteinPKC ), protein kinase A , or Ca(2+)-regulated kinases . |
| 0.7554 | 0.9964 | 1.0000 | Thus, proteinTNF alpha -induced NF-kappa B activation was found to be mediated by none of the major signal-mediating kinases such as protein kinase C ( PKC ), protein kinase A , or Ca(2+)-regulated kinases . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2347 | 20.1627 | 1.0000 | Furthermore, we found that cytoplasmic acidification facilitated proteinNF-kappa B activation by both TNF alpha and PKC , by a mechanism that increases NF-kappa B /I kappa B dissociation without affecting the NF-kappa B translocation step . |
| 2.2241 | 20.4541 | 1.0000 | Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC , by a mechanism that increases NF-kappa B /I kappa B dissociation without affecting the proteinNF-kappa B translocation step . |
| 2.2021 | 20.1041 | 0.9992 | Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC , by a mechanism that increases proteinNF-kappa B /I kappa B dissociation without affecting the NF-kappa B translocation step . |
| 1.4950 | 10.8736 | 1.0000 | Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both proteinTNF alpha and PKC , by a mechanism that increases NF-kappa B /I kappa B dissociation without affecting the NF-kappa B translocation step . |
| 1.4574 | 0.9223 | 10.5283 | Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC , by a mechanism that increases NF-kappa B protein/I kappa B dissociation without affecting the NF-kappa B translocation step . |
| 0.9168 | 1.0000 | 1.0000 | Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and proteinPKC , by a mechanism that increases NF-kappa B /I kappa B dissociation without affecting the NF-kappa B translocation step . |
| 1.9162 | 20.9514 | 10.1496 | Furthermore, we found that cytoplasmic acidification facilitated NF-kappa B activation by both TNF alpha and PKC , by a mechanism that increases proteinNF-kappa B /I kappa B dissociation without affecting the NF-kappa B translocation step . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8654 | 10.9643 | 10.7932 | The functional domains of the DNAmurine Thy-1 gene promoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6830 | 20.3032 | 1.0000 | The Thy-1 gene promoter resembles a "housekeeping" promoter in that it is located within a methylation-free island , lacks a canonical TATA box , and displays heterogeneity in the 5'-end termini of the RNAmRNA . |
| 2.1255 | 20.3919 | 0.9999 | The Thy-1 gene promoter resembles a DNA"housekeeping" promoter in that it is located within a methylation-free island , lacks a canonical TATA box , and displays heterogeneity in the 5'-end termini of the mRNA . |
| 1.4556 | 20.8472 | 0.9999 | The Thy-1 gene promoter resembles a "housekeeping" promoter in that it is located within a DNAmethylation-free island , lacks a canonical TATA box , and displays heterogeneity in the 5'-end termini of the mRNA . |
| 1.4356 | 10.5595 | 0.9987 | The DNAThy-1 gene promoter resembles a "housekeeping" promoter in that it is located within a methylation-free island , lacks a canonical TATA box , and displays heterogeneity in the 5'-end termini of the mRNA . |
| 2.1439 | 20.7755 | 1.0000 | The Thy-1 gene promoter resembles a "housekeeping" promoter in that it is located within a methylation-free island , lacks a canonical DNATATA box , and displays heterogeneity in the 5'-end termini of the mRNA . |
| The Thy-1 gene promoter resembles a "housekeeping" promoter in that it is located within a methylation-free island , lacks a canonical TATA box , and displays heterogeneity in the RNA5'-end termini of the mRNA . | |||
| The Thy-1 gene promoter resembles a "housekeeping" promoter in that it is located within a methylation-free island , lacks a DNAcanonical TATA box , and displays heterogeneity in the 5'-end termini of the mRNA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Using transgenic mice , we show that this DNApromoter does not confer any tissue specificity and is active only in a position-dependent manner . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4660 | 20.2564 | 0.9999 | It can only be activated in a tissue-specific manner by elements that lie downstream of the DNAinitiation site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1218 | 30.0276 | 10.8431 | We have analyzed the functional domains of the DNAminimal Thy-1 promoter and show that the dominant promoter elements consist of multiple binding sites for the transcription factor Sp1 , an inverted CCAAT box , and sequences proximal to the transcription start site . |
| 3.3788 | 30.6036 | 10.5975 | We have analyzed the functional domains of the minimal Thy-1 promoter and show that the dominant promoter elements consist of DNAmultiple binding sites for the transcription factor Sp1 , an inverted CCAAT box , and sequences proximal to the transcription start site . |
| 2.5829 | 20.6241 | 10.7343 | We have analyzed the functional domains of the minimal Thy-1 promoter and show that the DNAdominant promoter elements consist of multiple binding sites for the transcription factor Sp1 , an inverted CCAAT box , and sequences proximal to the transcription start site . |
| 2.0855 | 20.5331 | 0.9999 | We have analyzed the functional domains of the minimal Thy-1 promoter and show that the dominant promoter elements consist of multiple binding sites for the transcription factor Sp1 , an inverted DNACCAAT box , and sequences proximal to the transcription start site . |
| 1.3699 | 20.6558 | 0.9992 | We have analyzed the functional domains of the minimal Thy-1 promoter and show that the dominant promoter elements consist of multiple binding sites for the transcription factor Sp1 , an inverted CCAAT box , and sequences proximal to the DNAtranscription start site . |
| 1.3455 | 20.7476 | 0.9992 | We have analyzed the functional domains of the minimal Thy-1 promoter and show that the dominant promoter elements consist of multiple binding sites for the proteintranscription factor Sp1 , an inverted CCAAT box , and sequences proximal to the transcription start site . |
| 0.9644 | 1.0000 | 1.0000 | We have analyzed the functional domains of the minimal Thy-1 promoter and show that the dominant promoter elements consist of multiple binding sites for the transcription factor proteinSp1 , an inverted CCAAT box , and sequences proximal to the transcription start site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2151 | 20.5885 | 1.0000 | DNase I and gel mobility shift assays show the binding of a number of proteinnuclear factors to these elements , including Sp1 and CP1 . |
| 1.5457 | 10.9100 | 1.0000 | DNase I and gel mobility shift assays show the binding of a number of nuclear factors to these elements , including proteinSp1 and CP1 . |
| 0.8640 | 0.9999 | 1.0000 | DNase I and gel mobility shift assays show the binding of a number of nuclear factors to these elements , including Sp1 and proteinCP1 . |
| 0.9103 | 0.9999 | 1.0000 | proteinDNase I and gel mobility shift assays show the binding of a number of nuclear factors to these elements , including Sp1 and CP1 . |
| DNase I and gel mobility shift assays show the binding of a number of nuclear factors to these DNAelements , including Sp1 and CP1 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3326 | 20.3173 | 0.9996 | Our results show that the structure of this promoter only permits productive interactions of the two proteintranscription factors Sp1 and CP1 with the basal transcription machinery in the presence of enhancer sequences . |
| 2.3090 | 20.3468 | 0.9999 | Our results show that the structure of this promoter only permits productive interactions of the two transcription factors Sp1 and CP1 with the basal transcription machinery in the presence of DNAenhancer sequences . |
| 0.9871 | 1.0000 | 1.0000 | Our results show that the structure of this promoter only permits productive interactions of the two transcription factors Sp1 and proteinCP1 with the basal transcription machinery in the presence of enhancer sequences . |
| 0.9787 | 1.0000 | 1.0000 | Our results show that the structure of this promoter only permits productive interactions of the two transcription factors proteinSp1 and CP1 with the basal transcription machinery in the presence of enhancer sequences . |
| Our results show that the structure of this DNApromoter only permits productive interactions of the two transcription factors Sp1 and CP1 with the basal transcription machinery in the presence of enhancer sequences . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8226 | 20.2840 | 0.9996 | Nuclear factor kappa B activates proenkephalin transcription in cell_typeT lymphocytes . |
| 1.6358 | 0.9985 | 10.9769 | proteinNuclear factor kappa B activates proenkephalin transcription in T lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5179 | 20.0482 | 1.0000 | Upon activation, T lymphocytes accumulate high levels of the neuropeptide enkephalin which correlate with high levels of RNAproenkephalin mRNA in the cells. |
| 1.5760 | 10.4807 | 0.9999 | Upon activation, cell_typeT lymphocytes accumulate high levels of the neuropeptide enkephalin which correlate with high levels of proenkephalin mRNA in the cells. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4123 | 30.1602 | 10.7495 | The proenkephalin promoter contains a sequence GGGGACGTCCCC , named B2 , which is similar to the DNAkappa B sequence GGGGACTTTCC , the binding site of the transcription factor nuclear factor (NF)-kappa B . |
| 0.8616 | 1.0000 | 1.0000 | The proenkephalin promoter contains a sequence GGGGACGTCCCC , named DNAB2 , which is similar to the kappa B sequence GGGGACTTTCC , the binding site of the transcription factor nuclear factor (NF)-kappa B . |
| 4.7942 | 30.6474 | 20.6027 | The proenkephalin promoter contains a sequence GGGGACGTCCCC , named B2 , which is similar to the kappa B sequence GGGGACTTTCC , the binding site of the proteintranscription factor nuclear factor (NF)-kappa B . |
| 1.2726 | 10.5987 | 0.9999 | The DNAproenkephalin promoter contains a sequence GGGGACGTCCCC , named B2 , which is similar to the kappa B sequence GGGGACTTTCC , the binding site of the transcription factor nuclear factor (NF)-kappa B . |
| The proenkephalin promoter contains a sequence GGGGACGTCCCC , named B2 , which is similar to the kappa B sequence GGGGACTTTCC , the binding site of the proteintranscription factor nuclear factor (NF)-kappa B . | |||
| The proenkephalin promoter contains a sequence GGGGACGTCCCC , named B2 , which is similar to the kappa B sequence GGGGACTTTCC , the binding site of the transcription factor proteinnuclear factor (NF)-kappa B . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1687 | 20.1565 | 0.9999 | Activation of cell_typeT lymphocytes induces an NF-kappa B -like binding activity to the B2 site, concomitant with activation of the proenkephalin promoter . |
| 2.1393 | 20.2648 | 0.9999 | Activation of T lymphocytes induces an NF-kappa B -like binding activity to the B2 site, concomitant with activation of the DNAproenkephalin promoter . |
| 1.5219 | 10.8909 | 1.0000 | Activation of T lymphocytes induces an proteinNF-kappa B -like binding activity to the B2 site, concomitant with activation of the proenkephalin promoter . |
| Activation of T lymphocytes induces an NF-kappa B -like binding activity to the DNAB2 site, concomitant with activation of the proenkephalin promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2468 | 20.1993 | 1.0000 | Mutations at the DNAB2 site abolish this transcriptional activation . |
| Mutations at the DNAB2 site abolish this transcriptional activation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1793 | 20.0117 | 1.0000 | The purified homodimer (two p50s ) of the proteinDNA-binding subunit of NF-kappa B binds the B2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two p50s ) form of the factor. |
| 1.8300 | 10.1165 | 1.0000 | The purified homodimer (two p50s ) of the DNA-binding subunit of NF-kappa B binds the B2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two proteinp50s ) form of the factor. |
| 1.6160 | 10.5268 | 1.0000 | The purified homodimer (two p50s ) of the DNA-binding subunit of proteinNF-kappa B binds the B2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two p50s ) form of the factor. |
| 0.9134 | 1.0000 | 1.0000 | The purified homodimer (two p50s ) of the DNA-binding subunit of NF-kappa B binds the B2 site of proenkephalin relatively better than does the heterotetramer (two proteinp65s plus two p50s ) form of the factor. |
| 0.9061 | 1.0000 | 1.0000 | The purified homodimer (two proteinp50s ) of the DNA-binding subunit of NF-kappa B binds the B2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two p50s ) form of the factor. |
| 0.6910 | 1.0000 | 1.0000 | The purified homodimer (two p50s ) of the DNA-binding subunit of NF-kappa B binds the B2 site of proenkephalin relatively better than does the proteinheterotetramer (two p65s plus two p50s ) form of the factor. |
| 1.4893 | 10.6857 | 0.9999 | The purified homodimer (two p50s ) of the DNA-binding subunit of NF-kappa B binds the DNAB2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two p50s ) form of the factor. |
| 1.0176 | 10.1669 | 1.0000 | The proteinpurified homodimer (two p50s ) of the DNA-binding subunit of NF-kappa B binds the B2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two p50s ) form of the factor. |
| The purified proteinhomodimer (two p50s ) of the DNA-binding subunit of NF-kappa B binds the B2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two p50s ) form of the factor. | |||
| The purified homodimer (two p50s ) of the DNA-binding subunit of NF-kappa B binds the DNAB2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two p50s ) form of the factor. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2405 | 20.0459 | 1.0000 | Thus, it appears that the T-cell-specific activation of the DNAproenkephalin promoter is mediated by NF-kappa B . |
| 1.4861 | 10.8746 | 1.0000 | Thus, it appears that the T-cell-specific activation of the proenkephalin promoter is mediated by proteinNF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2960 | 20.9077 | 1.0000 | However, as NF-kappa B is ubiquitous and the transcriptional activation through the B2 site is T cell specific , yet another proteinT-cell-specific factor which synergizes with NF-kappa B should be considered. |
| 2.2874 | 20.4263 | 1.0000 | However, as NF-kappa B is ubiquitous and the transcriptional activation through the B2 site is T cell specific , yet another T-cell-specific factor which synergizes with proteinNF-kappa B should be considered. |
| 1.5790 | 10.9258 | 1.0000 | However, as proteinNF-kappa B is ubiquitous and the transcriptional activation through the B2 site is T cell specific , yet another T-cell-specific factor which synergizes with NF-kappa B should be considered. |
| 2.1580 | 20.1886 | 1.0000 | However, as NF-kappa B is ubiquitous and the transcriptional activation through the DNAB2 site is T cell specific , yet another T-cell-specific factor which synergizes with NF-kappa B should be considered. |
| 0.5534 | 0.9988 | 0.9994 | However, as NF-kappa B is ubiquitous and the transcriptional activation through the B2 site is cell_typeT cell specific , yet another T-cell-specific factor which synergizes with NF-kappa B should be considered. |
| However, as NF-kappa B is ubiquitous and the transcriptional activation through the DNAB2 site is T cell specific , yet another T-cell-specific factor which synergizes with NF-kappa B should be considered. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5783 | 10.9004 | 1.0000 | Induction of proteinNF-KB during monocyte differentiation by HIV type 1 infection . |
| Induction of NF-KB during cell_typemonocyte differentiation by HIV type 1 infection . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5461 | 20.3188 | 10.7881 | The production of human immunodeficiency virus type 1 ( HIV-1 ) progeny was followed in the cell_lineU937 promonocytic cell line after stimulation either with retinoic acid or PMA , and in purified human monocytes and macrophages . |
| 2.4739 | 30.2877 | 30.8365 | The production of cell_typehuman immunodeficiency virus type 1 ( HIV-1 ) progeny was followed in the U937 promonocytic cell line after stimulation either with retinoic acid or PMA , and in purified human monocytes and macrophages . |
| 1.9057 | 30.4736 | 10.4148 | The production of human immunodeficiency virus type 1 ( HIV-1 ) progeny was followed in the U937 promonocytic cell line after stimulation either with retinoic acid or PMA , and in cell_typepurified human monocytes and macrophages . |
| 0.8535 | 0.9999 | 0.9999 | The production of human immunodeficiency virus type 1 ( HIV-1 ) progeny was followed in the U937 promonocytic cell line after stimulation either with retinoic acid or PMA , and in purified human monocytes and cell_typemacrophages . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5842 | 20.2976 | 10.8167 | Electrophoretic mobility shift assays and Southwestern blotting experiments were used to detect the binding of cellular transactivation factor NF-KB to the DNAdouble repeat-KB enhancer sequence located in the long terminal repeat . |
| 4.0348 | 30.2543 | 10.9453 | Electrophoretic mobility shift assays and Southwestern blotting experiments were used to detect the binding of proteincellular transactivation factor NF-KB to the double repeat-KB enhancer sequence located in the long terminal repeat . |
| 3.4208 | 20.9610 | 10.4553 | Electrophoretic mobility shift assays and Southwestern blotting experiments were used to detect the binding of cellular transactivation factor NF-KB to the double repeat-KB enhancer sequence located in the DNAlong terminal repeat . |
| 0.9822 | 1.0000 | 1.0000 | Electrophoretic mobility shift assays and Southwestern blotting experiments were used to detect the binding of cellular transactivation factor proteinNF-KB to the double repeat-KB enhancer sequence located in the long terminal repeat . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3990 | 20.6173 | 1.0000 | PMA treatment , and not retinoic acid treatment of the cell_lineU937 cells acts in inducing NF-KB expression in the nuclei . |
| 1.6796 | 10.4775 | 1.0000 | PMA treatment , and not retinoic acid treatment of the U937 cells acts in inducing proteinNF-KB expression in the nuclei . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4836 | 20.0798 | 1.0000 | In nuclear extracts from monocytes or macrophages , induction of proteinNF-KB occurred only if the cells were previously infected with HIV-1 . |
| 1.6276 | 10.7965 | 1.0000 | In nuclear extracts from cell_typemonocytes or macrophages , induction of NF-KB occurred only if the cells were previously infected with HIV-1 . |
| 0.9074 | 0.9999 | 1.0000 | In nuclear extracts from monocytes or cell_typemacrophages , induction of NF-KB occurred only if the cells were previously infected with HIV-1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3938 | 20.5459 | 0.9963 | When U937 cells were infected with HIV-1 , no induction of proteinNF-KB factor was detected, whereas high level of progeny virions was produced, suggesting that this factor was not required for viral replication . |
| 2.3199 | 20.7368 | 1.0000 | When U937 cells were infected with HIV-1 , no induction of proteinNF-KB factor was detected, whereas high level of progeny virions was produced, suggesting that this factor was not required for viral replication . |
| 1.7641 | 10.6058 | 1.0000 | When cell_lineU937 cells were infected with HIV-1 , no induction of NF-KB factor was detected, whereas high level of progeny virions was produced, suggesting that this factor was not required for viral replication . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8212 | 20.5316 | 10.5212 | These results indicate that in cell_linemonocytic cell lineage , HIV-1 could mimic some differentiation/activation stimuli allowing nuclear NF-KB expression . |
| 1.5202 | 10.9287 | 1.0000 | These results indicate that in monocytic cell lineage , HIV-1 could mimic some differentiation/activation stimuli allowing nuclear proteinNF-KB expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4153 | 20.3379 | 10.5539 | Disruption of the DNAhuman SCL locus by " illegitimate" V-(D)-J recombinase activity . |
| 1.4541 | 10.9675 | 0.9999 | Disruption of the human SCL locus by " illegitimate" proteinV-(D)-J recombinase activity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5708 | 30.2303 | 10.8853 | A fusion complementary DNA in the cell_lineT cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative hematopoietic transcription factor SCL . |
| 2.4791 | 10.9029 | 10.2769 | A DNAfusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative hematopoietic transcription factor SCL . |
| 0.9643 | 0.9999 | 1.0000 | A fusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative hematopoietic transcription factor proteinSCL . |
| 4.2499 | 30.7171 | 10.6819 | A fusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the proteinputative hematopoietic transcription factor SCL . |
| A fusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative proteinhematopoietic transcription factor SCL . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6987 | 20.0240 | 10.5916 | The fusion cDNA results from an interstitial deletion between a previously unknown locus , SIL ( DNASCL interrupting locus ), and the 5' untranslated region of SCL . |
| 3.5649 | 20.5494 | 10.6207 | The fusion cDNA results from an interstitial deletion between a previously unknown locus , SIL ( SCL interrupting locus ), and the DNA5' untranslated region of SCL . |
| 1.4745 | 10.9124 | 0.9999 | The DNAfusion cDNA results from an interstitial deletion between a previously unknown locus , SIL ( SCL interrupting locus ), and the 5' untranslated region of SCL . |
| 0.8948 | 1.0000 | 1.0000 | The fusion cDNA results from an interstitial deletion between a previously unknown locus , DNASIL ( SCL interrupting locus ), and the 5' untranslated region of SCL . |
| 0.8861 | 1.0000 | 1.0000 | The fusion cDNA results from an interstitial deletion between a previously unknown locus , SIL ( SCL interrupting locus ), and the 5' untranslated region of DNASCL . |
| The fusion cDNA results from an interstitial deletion between a previously DNAunknown locus , SIL ( SCL interrupting locus ), and the 5' untranslated region of SCL . | |||
| The fusion cDNA results from an interstitial deletion between a previously unknown locus , SIL ( proteinSCL interrupting locus ), and the 5' untranslated region of SCL . | |||
| The fusion cDNA results from an interstitial deletion between a previously unknown locus , SIL ( SCL interrupting locus ), and the 5' untranslated region of proteinSCL . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8885 | 20.4589 | 10.4588 | Similar to 1;14 translocations , this deletion disrupts the DNASCL 5' regulatory region . |
| Similar to 1;14 translocations , this deletion disrupts the proteinSCL 5' regulatory region . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3112 | 20.6427 | 10.6053 | This event is probably mediated by V-(D)-J recombinase activity , although neither locus is an immunoglobulin or a proteinT cell receptor . |
| 1.5387 | 10.7455 | 1.0000 | This event is probably mediated by V-(D)-J recombinase activity , although neither locus is an proteinimmunoglobulin or a T cell receptor . |
| 1.5986 | 10.9526 | 1.0000 | This event is probably mediated by proteinV-(D)-J recombinase activity , although neither locus is an immunoglobulin or a T cell receptor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5663 | 20.0219 | 10.6461 | Two other cell_lineT cell lines , CEM and RPMI 8402 , have essentially identical deletions. |
| 0.9217 | 1.0000 | 1.0000 | Two other T cell lines , cell_lineCEM and RPMI 8402 , have essentially identical deletions. |
| 0.8084 | 0.9989 | 0.9999 | Two other T cell lines , CEM and cell_lineRPMI 8402 , have essentially identical deletions. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5786 | 10.9185 | 1.0000 | Thus, in cell_typelymphocytes , growth-affecting genes other than immune receptors risk rearrangements . |
| 1.4681 | 10.7590 | 0.9999 | Thus, in lymphocytes , DNAgrowth-affecting genes other than immune receptors risk rearrangements . |
| 1.3627 | 10.7429 | 1.0000 | Thus, in lymphocytes , growth-affecting genes other than proteinimmune receptors risk rearrangements . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7353 | 20.5074 | 10.7168 | Thyroid hormone receptors form distinct nuclear protein- dependent and independent complexes with a DNAthyroid hormone response element . |
| 1.5242 | 0.9987 | 10.8481 | proteinThyroid hormone receptors form distinct nuclear protein- dependent and independent complexes with a thyroid hormone response element . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.3290 | 30.2260 | 20.3261 | We have examined the binding of nuclear proteins and recombinant thyroid hormone receptors ( TRs ) to the DNApalindromic thyroid hormone responsive element AGGTCATGACCT ( TREp ) using a gel electrophoretic mobility shift assay . |
| 1.3935 | 10.7025 | 0.9999 | We have examined the binding of proteinnuclear proteins and recombinant thyroid hormone receptors ( TRs ) to the palindromic thyroid hormone responsive element AGGTCATGACCT ( TREp ) using a gel electrophoretic mobility shift assay . |
| 0.9742 | 1.0000 | 1.0000 | We have examined the binding of nuclear proteins and recombinant thyroid hormone receptors ( proteinTRs ) to the palindromic thyroid hormone responsive element AGGTCATGACCT ( TREp ) using a gel electrophoretic mobility shift assay . |
| 0.9530 | 1.0000 | 1.0000 | We have examined the binding of nuclear proteins and recombinant thyroid hormone receptors ( TRs ) to the palindromic thyroid hormone responsive element AGGTCATGACCT ( DNATREp ) using a gel electrophoretic mobility shift assay . |
| 2.2150 | 10.7866 | 10.7863 | We have examined the binding of nuclear proteins and recombinant proteinthyroid hormone receptors ( TRs ) to the palindromic thyroid hormone responsive element AGGTCATGACCT ( TREp ) using a gel electrophoretic mobility shift assay . |
| We have examined the binding of nuclear proteins and proteinrecombinant thyroid hormone receptors ( TRs ) to the palindromic thyroid hormone responsive element AGGTCATGACCT ( TREp ) using a gel electrophoretic mobility shift assay . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5676 | 20.5793 | 10.9232 | Four specific protein-DNA complexes were detected after incubation of nuclear extracts ( NE ) from cell_lineT3-responsive pituitary (GH3) cells with a TREp -containing DNA fragment . |
| 3.6381 | 20.2442 | 10.5725 | Four specific protein-DNA complexes were detected after incubation of nuclear extracts ( NE ) from T3-responsive pituitary (GH3) cells with a DNATREp -containing DNA fragment . |
| 2.0096 | 20.4921 | 1.0000 | Four specific proteinprotein-DNA complexes were detected after incubation of nuclear extracts ( NE ) from T3-responsive pituitary (GH3) cells with a TREp -containing DNA fragment . |
| 1.4981 | 10.5081 | 0.9967 | Four specific protein-DNA complexes were detected after incubation of nuclear extracts ( NE ) from T3-responsive pituitary (GH3) cells with a DNATREp -containing DNA fragment . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8357 | 10.8366 | 10.9834 | This was compared with the TREp binding of proteinreticulocyte lysate-synthesized TRs . |
| 1.4490 | 10.6195 | 1.0000 | This was compared with the DNATREp binding of reticulocyte lysate-synthesized TRs . |
| This was compared with the TREp binding of reticulocyte lysate-synthesized proteinTRs . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8144 | 20.0208 | 10.2641 | TR alpha 1 and proteinTR beta 2 each formed a single major TR : TREp complex which comigrated with the least retarded complex formed by GH3 NE , while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer . |
| 3.6101 | 20.8098 | 10.9538 | TR alpha 1 and TR beta 2 each formed a single major TR : TREp complex which comigrated with the least retarded complex formed by GH3 NE , while proteinTR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer . |
| 2.2153 | 20.6854 | 1.0000 | TR alpha 1 and TR beta 2 each formed a single major TR : TREp complex which comigrated with the least retarded complex formed by GH3 NE , while TR beta 1 formed multiple complexes suggesting that it can bind to DNATREp as an oligomer . |
| 2.0587 | 20.7345 | 10.7276 | TR alpha 1 and TR beta 2 each formed a single major proteinTR : TREp complex which comigrated with the least retarded complex formed by GH3 NE , while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer . |
| 1.5581 | 0.9984 | 10.3210 | proteinTR alpha 1 and TR beta 2 each formed a single major TR : TREp complex which comigrated with the least retarded complex formed by GH3 NE , while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer . |
| 1.4657 | 10.2170 | 0.9981 | TR alpha 1 and TR beta 2 each formed a single major proteinTR : TREp complex which comigrated with the least retarded complex formed by GH3 NE , while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer . |
| 0.6228 | 1.0000 | 0.9656 | TR alpha 1 and TR beta 2 each formed a single major TR : DNATREp complex which comigrated with the least retarded complex formed by GH3 NE , while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer . |
| 1.4456 | 10.8302 | 1.0000 | TR alpha 1 and TR beta 2 each formed a single major TR : TREp complex which comigrated with the least retarded complex formed by proteinGH3 NE , while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer . |
| 0.5667 | 0.9858 | 0.9998 | TR alpha 1 and TR beta 2 each formed a single major TR : proteinTREp complex which comigrated with the least retarded complex formed by GH3 NE , while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer . |
| TR alpha 1 and TR beta 2 each formed a single major TR : TREp complex which comigrated with the least retarded complex formed by GH3 NE , while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an proteinoligomer . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7035 | 20.6364 | 10.9288 | Interestingly, coincubation of 35S- TR alpha 1 , GH3 NE , and unlabeled TREp resulted in not only the 35S-TR: TREp complex , but in two additional more greatly retarded complexes containing protein35S- TR alpha 1 and comigrating with those formed by GH3 extract alone. |
| 3.6650 | 20.5181 | 10.7599 | Interestingly, coincubation of protein35S- TR alpha 1 , GH3 NE , and unlabeled TREp resulted in not only the 35S-TR: TREp complex , but in two additional more greatly retarded complexes containing 35S- TR alpha 1 and comigrating with those formed by GH3 extract alone. |
| 2.3129 | 20.6035 | 0.9999 | Interestingly, coincubation of 35S- TR alpha 1 , GH3 NE , and unlabeled TREp resulted in not only the protein35S-TR: TREp complex , but in two additional more greatly retarded complexes containing 35S- TR alpha 1 and comigrating with those formed by GH3 extract alone. |
| 1.3458 | 0.9997 | 10.9558 | Interestingly, coincubation of 35S- proteinTR alpha 1 , GH3 NE , and unlabeled TREp resulted in not only the 35S-TR: TREp complex , but in two additional more greatly retarded complexes containing 35S- TR alpha 1 and comigrating with those formed by GH3 extract alone. |
| 1.3276 | 0.9999 | 10.9012 | Interestingly, coincubation of 35S- TR alpha 1 , GH3 NE , and unlabeled TREp resulted in not only the 35S-TR: TREp complex , but in two additional more greatly retarded complexes containing 35S- proteinTR alpha 1 and comigrating with those formed by GH3 extract alone. |
| 0.8246 | 1.0000 | 1.0000 | Interestingly, coincubation of 35S- TR alpha 1 , GH3 NE , and unlabeled DNATREp resulted in not only the 35S-TR: TREp complex , but in two additional more greatly retarded complexes containing 35S- TR alpha 1 and comigrating with those formed by GH3 extract alone. |
| 0.5345 | 1.0000 | 0.9860 | Interestingly, coincubation of 35S- TR alpha 1 , GH3 NE , and unlabeled TREp resulted in not only the 35S-TR: DNATREp complex , but in two additional more greatly retarded complexes containing 35S- TR alpha 1 and comigrating with those formed by GH3 extract alone. |
| 1.2908 | 10.3021 | 0.9998 | Interestingly, coincubation of 35S- TR alpha 1 , GH3 NE , and unlabeled TREp resulted in not only the 35S-TR: TREp complex , but in two additional more greatly proteinretarded complexes containing 35S- TR alpha 1 and comigrating with those formed by GH3 extract alone. |
| 0.5903 | 0.9945 | 1.0000 | Interestingly, coincubation of 35S- TR alpha 1 , proteinGH3 NE , and unlabeled TREp resulted in not only the 35S-TR: TREp complex , but in two additional more greatly retarded complexes containing 35S- TR alpha 1 and comigrating with those formed by GH3 extract alone. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6882 | 10.9392 | 0.9999 | Incubation of each of the TRs with NE from cell_lineCOS-7 cells , which do not possess sufficient endogenous TRs to mediate T3-responses , resulted in formation of a new, more greatly shifted complex . |
| 0.8674 | 1.0000 | 1.0000 | Incubation of each of the TRs with NE from COS-7 cells , which do not possess sufficient endogenous proteinTRs to mediate T3-responses , resulted in formation of a new, more greatly shifted complex . |
| 0.8557 | 0.9998 | 1.0000 | Incubation of each of the proteinTRs with NE from COS-7 cells , which do not possess sufficient endogenous TRs to mediate T3-responses , resulted in formation of a new, more greatly shifted complex . |
| 2.2345 | 20.4945 | 1.0000 | Incubation of each of the TRs with NE from COS-7 cells , which do not possess sufficient proteinendogenous TRs to mediate T3-responses , resulted in formation of a new, more greatly shifted complex . |
| 0.8349 | 0.9999 | 1.0000 | Incubation of each of the TRs with proteinNE from COS-7 cells , which do not possess sufficient endogenous TRs to mediate T3-responses , resulted in formation of a new, more greatly shifted complex . |
| 0.6601 | 0.9998 | 1.0000 | Incubation of each of the TRs with NE from COS-7 cells , which do not possess sufficient endogenous TRs to mediate T3-responses , resulted in formation of a new, more greatly shifted proteincomplex . |
| Incubation of each of the TRs with NE from COS-7 cells , which do not possess sufficient endogenous TRs to mediate T3-responses , resulted in formation of a new, more proteingreatly shifted complex . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1258 | 10.8485 | 10.8617 | A similar, heat labile activity which altered mobility of the TR:TRE complex was also present in NE from cell_lineT3-unresponsive JEG-3 cells . |
| 2.1536 | 20.1374 | 1.0000 | A similar, heat labile activity which altered mobility of the proteinTR:TRE complex was also present in NE from T3-unresponsive JEG-3 cells . |
| 1.5559 | 10.4459 | 1.0000 | A similar, heat labile activity which altered mobility of the TR:TRE complex was also present in proteinNE from T3-unresponsive JEG-3 cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8197 | 10.8047 | 1.0000 | At high concentration of NE , all of the TR bound to DNATREp was more greatly retarded than in the absence of NE . |
| 1.6897 | 10.9962 | 1.0000 | At high concentration of NE , all of the proteinTR bound to TREp was more greatly retarded than in the absence of NE . |
| 2.4028 | 20.0504 | 1.0000 | At high concentration of proteinNE , all of the TR bound to TREp was more greatly retarded than in the absence of NE . |
| 2.2471 | 20.4383 | 1.0000 | At high concentration of NE , all of the TR bound to TREp was more greatly retarded than in the absence of proteinNE . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9284 | 20.9502 | 10.3765 | Truncation of proteinTR alpha 1 at amino acid 210 prevented additional complex formation in the presence of NE without affecting DNA binding , suggesting that the carboxyl-terminus of the TRs is essential for interaction with nuclear proteins . |
| 2.3349 | 10.5029 | 10.6443 | Truncation of TR alpha 1 at proteinamino acid 210 prevented additional complex formation in the presence of NE without affecting DNA binding , suggesting that the carboxyl-terminus of the TRs is essential for interaction with nuclear proteins . |
| 2.1481 | 20.6673 | 0.9999 | Truncation of TR alpha 1 at amino acid 210 prevented additional complex formation in the presence of NE without affecting DNA binding , suggesting that the carboxyl-terminus of the TRs is essential for interaction with proteinnuclear proteins . |
| 1.5795 | 10.4350 | 1.0000 | Truncation of TR alpha 1 at amino acid 210 prevented additional complex formation in the presence of NE without affecting DNA binding , suggesting that the carboxyl-terminus of the proteinTRs is essential for interaction with nuclear proteins . |
| 1.4909 | 10.7915 | 1.0000 | Truncation of TR alpha 1 at amino acid 210 prevented additional complex formation in the presence of NE without affecting DNA binding , suggesting that the proteincarboxyl-terminus of the TRs is essential for interaction with nuclear proteins . |
| 1.5505 | 10.2569 | 1.0000 | Truncation of TR alpha 1 at amino acid 210 prevented additional complex formation in the presence of proteinNE without affecting DNA binding , suggesting that the carboxyl-terminus of the TRs is essential for interaction with nuclear proteins . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9808 | 20.7145 | 10.6722 | Cell-specific differences in activation of DNANF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by tumor necrosis factor . |
| 2.8385 | 20.7383 | 10.9818 | Cell-specific differences in activation of NF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by proteintumor necrosis factor . |
| 1.9436 | 20.8512 | 0.9705 | Cell-specific differences in activation of proteinNF-kappa B regulatory elements of human immunodeficiency virus and beta interferon promoters by tumor necrosis factor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0478 | 20.4518 | 10.6667 | Three aspects of the involvement of proteintumor necrosis factor in human immunodeficiency virus ( HIV ) pathogenesis were examined. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1611 | 20.6452 | 20.8521 | Tumor necrosis factor alpha ( TNF-alpha ) mRNA production was analyzed by polymerase chain reaction amplification in monocytic U937 cells and in a cell_linechronically HIV infected U937 cell line ( U9-IIIB ). |
| 4.0035 | 20.9615 | 10.9971 | Tumor necrosis factor alpha ( TNF-alpha ) mRNA production was analyzed by polymerase chain reaction amplification in cell_linemonocytic U937 cells and in a chronically HIV infected U937 cell line ( U9-IIIB ). |
| 1.6080 | 0.9494 | 10.3129 | RNATumor necrosis factor alpha ( TNF-alpha ) mRNA production was analyzed by polymerase chain reaction amplification in monocytic U937 cells and in a chronically HIV infected U937 cell line ( U9-IIIB ). |
| 1.4430 | 0.9982 | 10.3031 | proteinTumor necrosis factor alpha ( TNF-alpha ) mRNA production was analyzed by polymerase chain reaction amplification in monocytic U937 cells and in a chronically HIV infected U937 cell line ( U9-IIIB ). |
| 0.9629 | 1.0000 | 0.9991 | Tumor necrosis factor alpha ( proteinTNF-alpha ) mRNA production was analyzed by polymerase chain reaction amplification in monocytic U937 cells and in a chronically HIV infected U937 cell line ( U9-IIIB ). |
| 0.8769 | 0.9999 | 1.0000 | Tumor necrosis factor alpha ( TNF-alpha ) mRNA production was analyzed by polymerase chain reaction amplification in monocytic U937 cells and in a chronically HIV infected U937 cell line ( cell_lineU9-IIIB ). |
| 1.4318 | 0.9868 | 10.9727 | Tumor necrosis factor alpha ( TNF-alpha ) mRNA production was analyzed by polymerase chain reaction amplification in monocytic U937 cells and in a chronically HIV infected cell_lineU937 cell line ( U9-IIIB ). |
| 0.7177 | 0.9641 | 0.9998 | Tumor necrosis factor alpha ( RNATNF-alpha ) mRNA production was analyzed by polymerase chain reaction amplification in monocytic U937 cells and in a chronically HIV infected U937 cell line ( U9-IIIB ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2750 | 20.0437 | 0.9999 | TNF-alpha RNA was undetectable in U937 cells , whereas a low constitutive level was detected in cell_lineU9-IIIB cells . |
| 1.5062 | 10.9428 | 0.9999 | TNF-alpha RNA was undetectable in cell_lineU937 cells , whereas a low constitutive level was detected in U9-IIIB cells . |
| 0.9006 | 0.9982 | 1.0000 | RNATNF-alpha RNA was undetectable in U937 cells , whereas a low constitutive level was detected in U9-IIIB cells . |
| 0.8355 | 1.0000 | 0.9813 | proteinTNF-alpha RNA was undetectable in U937 cells , whereas a low constitutive level was detected in U9-IIIB cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3465 | 20.8144 | 1.0000 | Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of RNATNF-alpha RNA in U9-IIIB cells compared with U937 cells , suggesting that HIV-infected monocytic cells produced higher levels of TNF-alpha than did normal cells after a secondary virus infection . |
| 2.0760 | 20.7605 | 0.9879 | Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of proteinTNF-alpha RNA in U9-IIIB cells compared with U937 cells , suggesting that HIV-infected monocytic cells produced higher levels of TNF-alpha than did normal cells after a secondary virus infection . |
| 1.6875 | 10.1713 | 1.0000 | Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of TNF-alpha RNA in U9-IIIB cells compared with U937 cells , suggesting that HIV-infected monocytic cells produced higher levels of proteinTNF-alpha than did normal cells after a secondary virus infection . |
| 1.5877 | 10.8036 | 0.9999 | Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of TNF-alpha RNA in cell_lineU9-IIIB cells compared with U937 cells , suggesting that HIV-infected monocytic cells produced higher levels of TNF-alpha than did normal cells after a secondary virus infection . |
| 1.5352 | 10.7311 | 0.9999 | Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of TNF-alpha RNA in U9-IIIB cells compared with cell_lineU937 cells , suggesting that HIV-infected monocytic cells produced higher levels of TNF-alpha than did normal cells after a secondary virus infection . |
| 3.8796 | 20.9513 | 10.9828 | Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of TNF-alpha RNA in U9-IIIB cells compared with U937 cells , suggesting that cell_typeHIV-infected monocytic cells produced higher levels of TNF-alpha than did normal cells after a secondary virus infection . |
| 1.5624 | 10.3168 | 0.9999 | Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of TNF-alpha RNA in U9-IIIB cells compared with U937 cells , suggesting that HIV-infected monocytic cells produced higher levels of TNF-alpha than did cell_typenormal cells after a secondary virus infection . |
| 1.2995 | 1.0000 | 10.2919 | Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of TNF-alpha RNA in U9-IIIB cells compared with U937 cells , suggesting that HIV-infected cell_typemonocytic cells produced higher levels of TNF-alpha than did normal cells after a secondary virus infection . |
| Paramyxovirus infection induced a 5- to 10-fold increase in the steady-state level of TNF-alpha RNA in U9-IIIB cells compared with U937 cells , suggesting that cell_lineHIV-infected monocytic cells produced higher levels of TNF-alpha than did normal cells after a secondary virus infection . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7070 | 20.7688 | 10.8778 | The effects of TNF-alpha on gene expression were examined by transient expression assays using DNAreporter chloramphenicol acetyltransferase plasmids linked to regulatory elements from the HIV long terminal repeat ( LTR ) and the beta interferon promoter . |
| 3.8355 | 20.8065 | 10.6167 | The effects of TNF-alpha on gene expression were examined by transient expression assays using reporter chloramphenicol acetyltransferase plasmids linked to regulatory elements from the DNAHIV long terminal repeat ( LTR ) and the beta interferon promoter . |
| 3.5108 | 20.3525 | 10.8408 | The effects of TNF-alpha on gene expression were examined by transient expression assays using reporter chloramphenicol acetyltransferase plasmids linked to regulatory elements from the HIV long terminal repeat ( LTR ) and the DNAbeta interferon promoter . |
| 2.1458 | 20.6895 | 1.0000 | The effects of proteinTNF-alpha on gene expression were examined by transient expression assays using reporter chloramphenicol acetyltransferase plasmids linked to regulatory elements from the HIV long terminal repeat ( LTR ) and the beta interferon promoter . |
| 1.3463 | 10.7024 | 0.9999 | The effects of TNF-alpha on gene expression were examined by transient expression assays using reporter chloramphenicol acetyltransferase plasmids linked to DNAregulatory elements from the HIV long terminal repeat ( LTR ) and the beta interferon promoter . |
| 0.9315 | 1.0000 | 1.0000 | The effects of TNF-alpha on gene expression were examined by transient expression assays using reporter chloramphenicol acetyltransferase plasmids linked to regulatory elements from the HIV long terminal repeat ( DNALTR ) and the beta interferon promoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8748 | 30.0326 | 10.9961 | In U937 and Jurkat T lymphoid cells , the inducibility of the different hybrid promoters by TNF-alpha or phorbol ester varied in a cell type- and promoter context-specific manner; the levels of gene activity of DNANF-kappa B -containing plasmids correlated directly with induction of NF-kappa B DNA-binding activity . |
| 2.1889 | 20.5619 | 1.0000 | In U937 and Jurkat T lymphoid cells , the inducibility of the different hybrid promoters by TNF-alpha or phorbol ester varied in a cell type- and promoter context-specific manner; the levels of gene activity of NF-kappa B -containing plasmids correlated directly with induction of proteinNF-kappa B DNA-binding activity . |
| 2.0866 | 20.3425 | 0.9714 | In U937 and Jurkat T lymphoid cells , the inducibility of the different hybrid promoters by TNF-alpha or phorbol ester varied in a cell type- and promoter context-specific manner; the levels of gene activity of proteinNF-kappa B -containing plasmids correlated directly with induction of NF-kappa B DNA-binding activity . |
| 1.4139 | 10.6690 | 0.9999 | In U937 and Jurkat T lymphoid cells , the inducibility of the different DNAhybrid promoters by TNF-alpha or phorbol ester varied in a cell type- and promoter context-specific manner; the levels of gene activity of NF-kappa B -containing plasmids correlated directly with induction of NF-kappa B DNA-binding activity . |
| 0.9039 | 1.0000 | 1.0000 | In U937 and Jurkat T lymphoid cells , the inducibility of the different hybrid promoters by proteinTNF-alpha or phorbol ester varied in a cell type- and promoter context-specific manner; the levels of gene activity of NF-kappa B -containing plasmids correlated directly with induction of NF-kappa B DNA-binding activity . |
| 3.2043 | 20.8067 | 10.4623 | In U937 and cell_lineJurkat T lymphoid cells , the inducibility of the different hybrid promoters by TNF-alpha or phorbol ester varied in a cell type- and promoter context-specific manner; the levels of gene activity of NF-kappa B -containing plasmids correlated directly with induction of NF-kappa B DNA-binding activity . |
| 0.8872 | 0.9992 | 1.0000 | In cell_lineU937 and Jurkat T lymphoid cells , the inducibility of the different hybrid promoters by TNF-alpha or phorbol ester varied in a cell type- and promoter context-specific manner; the levels of gene activity of NF-kappa B -containing plasmids correlated directly with induction of NF-kappa B DNA-binding activity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2506 | 30.9153 | 10.4441 | Although the intact beta interferon promoter was only weakly stimulated by phorbol ester or TNF-alpha , multimers of the DNAPRDII NF-kappa B -binding domain were inducible by both agents. |
| 2.4895 | 20.7038 | 10.5736 | Although the intact DNAbeta interferon promoter was only weakly stimulated by phorbol ester or TNF-alpha , multimers of the PRDII NF-kappa B -binding domain were inducible by both agents. |
| 1.4797 | 10.3830 | 1.0000 | Although the intact beta interferon promoter was only weakly stimulated by phorbol ester or proteinTNF-alpha , multimers of the PRDII NF-kappa B -binding domain were inducible by both agents. |
| 0.8540 | 1.0000 | 0.9685 | Although the intact beta interferon promoter was only weakly stimulated by phorbol ester or TNF-alpha , multimers of the PRDII proteinNF-kappa B -binding domain were inducible by both agents. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1835 | 20.3495 | 0.9999 | TNF-alpha was able to increase expression of the HIV LTR in T cells , but in cell_typemonocytic cells , TNF-alpha did not induce the HIV LTR above a constitutive level of activity . |
| 2.1689 | 20.8578 | 1.0000 | TNF-alpha was able to increase expression of the HIV LTR in T cells , but in monocytic cells , TNF-alpha did not induce the DNAHIV LTR above a constitutive level of activity . |
| 2.1613 | 20.7905 | 0.9999 | TNF-alpha was able to increase expression of the DNAHIV LTR in T cells , but in monocytic cells , TNF-alpha did not induce the HIV LTR above a constitutive level of activity . |
| 1.4628 | 10.8642 | 0.9998 | TNF-alpha was able to increase expression of the HIV LTR in cell_typeT cells , but in monocytic cells , TNF-alpha did not induce the HIV LTR above a constitutive level of activity . |
| 0.9817 | 1.0000 | 1.0000 | proteinTNF-alpha was able to increase expression of the HIV LTR in T cells , but in monocytic cells , TNF-alpha did not induce the HIV LTR above a constitutive level of activity . |
| 0.9491 | 1.0000 | 1.0000 | TNF-alpha was able to increase expression of the HIV LTR in T cells , but in monocytic cells , proteinTNF-alpha did not induce the HIV LTR above a constitutive level of activity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6025 | 20.8567 | 1.0000 | This level of NF-kappa B -independent activity appears to be sufficient for virus multiplication , since TNF-alpha treatment had no effect on the kinetics of de novo HIV type 1 ( HIV-1 ) infection and RNAviral RNA production in U937 cells . |
| 2.5331 | 20.4056 | 1.0000 | This level of proteinNF-kappa B -independent activity appears to be sufficient for virus multiplication , since TNF-alpha treatment had no effect on the kinetics of de novo HIV type 1 ( HIV-1 ) infection and viral RNA production in U937 cells . |
| 2.4331 | 20.3431 | 0.9999 | This level of NF-kappa B -independent activity appears to be sufficient for virus multiplication , since TNF-alpha treatment had no effect on the kinetics of de novo HIV type 1 ( HIV-1 ) infection and viral RNA production in cell_lineU937 cells . |
| 0.9491 | 1.0000 | 1.0000 | This level of NF-kappa B -independent activity appears to be sufficient for virus multiplication , since proteinTNF-alpha treatment had no effect on the kinetics of de novo HIV type 1 ( HIV-1 ) infection and viral RNA production in U937 cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5309 | 20.1828 | 1.0000 | However, in Jurkat cells , TNF-alpha dramatically enhanced the spread of HIV-1 through the cell population and increased RNAviral RNA synthesis , indicating that in T cells HIV-1 multiplication was stimulated by TNF-alpha treatment . |
| 2.4375 | 20.0528 | 0.9999 | However, in cell_lineJurkat cells , TNF-alpha dramatically enhanced the spread of HIV-1 through the cell population and increased viral RNA synthesis , indicating that in T cells HIV-1 multiplication was stimulated by TNF-alpha treatment . |
| 2.3573 | 20.1657 | 0.9999 | However, in Jurkat cells , TNF-alpha dramatically enhanced the spread of HIV-1 through the cell population and increased viral RNA synthesis , indicating that in cell_typeT cells HIV-1 multiplication was stimulated by TNF-alpha treatment . |
| 1.7304 | 10.1851 | 1.0000 | However, in Jurkat cells , TNF-alpha dramatically enhanced the spread of HIV-1 through the cell population and increased viral RNA synthesis , indicating that in T cells HIV-1 multiplication was stimulated by proteinTNF-alpha treatment . |
| 0.9395 | 1.0000 | 1.0000 | However, in Jurkat cells , proteinTNF-alpha dramatically enhanced the spread of HIV-1 through the cell population and increased viral RNA synthesis , indicating that in T cells HIV-1 multiplication was stimulated by TNF-alpha treatment . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4590 | 20.0159 | 10.7811 | Functional analysis of cis-linked regulatory sequences in the DNAHLA DRA promoter by transcription in vitro. |
| 3.4184 | 20.4203 | 10.6515 | Functional analysis of DNAcis-linked regulatory sequences in the HLA DRA promoter by transcription in vitro. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.0513 | 20.4813 | 20.7040 | Two consensus sequences, called X and Y boxes , capable of binding nuclear proteins and regulating expression in B cells have been defined within the immediate upstream region of DNAmajor histocompatibility complex (MHC) class II promoters . |
| 2.0849 | 20.0567 | 0.9999 | Two consensus sequences, called X and Y boxes , capable of binding nuclear proteins and regulating expression in cell_typeB cells have been defined within the immediate upstream region of major histocompatibility complex (MHC) class II promoters . |
| 0.6866 | 0.9988 | 0.9999 | Two consensus sequences, called X and Y boxes , capable of binding proteinnuclear proteins and regulating expression in B cells have been defined within the immediate upstream region of major histocompatibility complex (MHC) class II promoters . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9120 | 20.5388 | 10.7119 | Unlike other class II promoters , the DNAHLA-DR alpha (DRA) promoter also contains one element identical to the "octamer" motif of immunoglobulin variable region promoters that is responsible for B cell-specific transcription . |
| 3.8309 | 20.0376 | 10.7306 | Unlike other class II promoters , the HLA-DR alpha (DRA) promoter also contains one element identical to the "octamer" motif of DNAimmunoglobulin variable region promoters that is responsible for B cell-specific transcription . |
| 3.7693 | 20.4306 | 10.9834 | Unlike other DNAclass II promoters , the HLA-DR alpha (DRA) promoter also contains one element identical to the "octamer" motif of immunoglobulin variable region promoters that is responsible for B cell-specific transcription . |
| 1.0709 | 10.8128 | 0.9998 | Unlike other class II promoters , the HLA-DR alpha (DRA) promoter also contains one element identical to the DNA"octamer" motif of immunoglobulin variable region promoters that is responsible for B cell-specific transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2384 | 20.6990 | 0.9999 | This " octamer " in the context of DRA appears capable of binding both the ubiquitous ( OTF-1 ) and lymphoid-specific ( OTF-2 ) "octamer" binding proteins , but at least one other distinct protein"octamer" complex was found. |
| 0.9767 | 1.0000 | 1.0000 | This " octamer " in the context of DRA appears capable of binding both the ubiquitous ( proteinOTF-1 ) and lymphoid-specific ( OTF-2 ) "octamer" binding proteins , but at least one other distinct "octamer" complex was found. |
| 0.9607 | 1.0000 | 1.0000 | This " octamer " in the context of DRA appears capable of binding both the ubiquitous ( OTF-1 ) and lymphoid-specific ( proteinOTF-2 ) "octamer" binding proteins , but at least one other distinct "octamer" complex was found. |
| 0.9220 | 1.0000 | 0.9995 | This " DNAoctamer " in the context of DRA appears capable of binding both the ubiquitous ( OTF-1 ) and lymphoid-specific ( OTF-2 ) "octamer" binding proteins , but at least one other distinct "octamer" complex was found. |
| 1.6044 | 10.1121 | 1.0000 | This " octamer " in the context of DNADRA appears capable of binding both the ubiquitous ( OTF-1 ) and lymphoid-specific ( OTF-2 ) "octamer" binding proteins , but at least one other distinct "octamer" complex was found. |
| This " octamer " in the context of proteinDRA appears capable of binding both the ubiquitous ( OTF-1 ) and lymphoid-specific ( OTF-2 ) "octamer" binding proteins , but at least one other distinct "octamer" complex was found. | |||
| This " octamer " in the context of DRA appears capable of binding both the proteinubiquitous ( OTF-1 ) and lymphoid-specific ( OTF-2 ) "octamer" binding proteins , but at least one other distinct "octamer" complex was found. | |||
| This " octamer " in the context of DRA appears capable of binding both the ubiquitous ( OTF-1 ) and proteinlymphoid-specific ( OTF-2 ) "octamer" binding proteins , but at least one other distinct "octamer" complex was found. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.9543 | 20.8205 | 10.7081 | In order to characterize the function of cis-acting elements , we have developed an in vitro system in which a DRA promoter construct is transcribed more efficiently in extracts from B cells than in extracts from cell_lineclass II-negative HeLa cells . |
| 2.2611 | 20.9703 | 0.9999 | In order to characterize the function of cis-acting elements , we have developed an in vitro system in which a DNADRA promoter construct is transcribed more efficiently in extracts from B cells than in extracts from class II-negative HeLa cells . |
| 2.2299 | 20.5942 | 0.9999 | In order to characterize the function of cis-acting elements , we have developed an in vitro system in which a DRA promoter construct is transcribed more efficiently in extracts from cell_typeB cells than in extracts from class II-negative HeLa cells . |
| 2.1626 | 20.8387 | 1.0000 | In order to characterize the function of DNAcis-acting elements , we have developed an in vitro system in which a DRA promoter construct is transcribed more efficiently in extracts from B cells than in extracts from class II-negative HeLa cells . |
| 1.6280 | 20.8656 | 0.7477 | In order to characterize the function of cis-acting elements , we have developed an in vitro system in which a DNADRA promoter construct is transcribed more efficiently in extracts from B cells than in extracts from class II-negative HeLa cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2348 | 20.2914 | 0.9999 | 5' deletion constructs which lacked the Y box , but retained the DNA"octamer" motif and TATA box were completely inactive, and internal deletion of the Y box reduced transcription by 95%. |
| 2.2221 | 20.5342 | 1.0000 | 5' deletion constructs which lacked the Y box , but retained the "octamer" motif and TATA box were completely inactive, and internal deletion of the DNAY box reduced transcription by 95%. |
| 2.1688 | 20.2753 | 1.0000 | 5' deletion constructs which lacked the DNAY box , but retained the "octamer" motif and TATA box were completely inactive, and internal deletion of the Y box reduced transcription by 95%. |
| 1.5364 | 10.5905 | 0.9999 | 5' deletion constructs which lacked the Y box , but retained the "octamer" motif and DNATATA box were completely inactive, and internal deletion of the Y box reduced transcription by 95%. |
| 1.5528 | 0.9981 | 10.8279 | DNA5' deletion constructs which lacked the Y box , but retained the "octamer" motif and TATA box were completely inactive, and internal deletion of the Y box reduced transcription by 95%. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8591 | 20.6004 | 10.7849 | Using supercoiled, but not linear templates, we observed differences in transcription efficiencies from templates lacking or disrupting the DNAX consensus element that reflect effects of random replacement of X box sequences in transient expression assays . |
| 3.1017 | 20.8736 | 10.8700 | Using supercoiled, but not linear templates, we observed differences in transcription efficiencies from templates lacking or disrupting the X consensus element that reflect effects of random replacement of DNAX box sequences in transient expression assays . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2333 | 20.0906 | 1.0000 | Demonstration of the complete dependence on the Y box in this system suggests that, despite its demonstrated importance in the DNADRA promoter , the DRA "octamer" does not utilize OTF-2 in a manner analogous to immunoglobulin promoters in B cells . |
| 2.2257 | 20.1758 | 1.0000 | Demonstration of the complete dependence on the DNAY box in this system suggests that, despite its demonstrated importance in the DRA promoter , the DRA "octamer" does not utilize OTF-2 in a manner analogous to immunoglobulin promoters in B cells . |
| 2.2173 | 20.2810 | 0.9999 | Demonstration of the complete dependence on the Y box in this system suggests that, despite its demonstrated importance in the DRA promoter , the DRA "octamer" does not utilize OTF-2 in a manner analogous to DNAimmunoglobulin promoters in B cells . |
| 1.6419 | 10.3360 | 0.9997 | Demonstration of the complete dependence on the Y box in this system suggests that, despite its demonstrated importance in the DRA promoter , the DRA "octamer" does not utilize OTF-2 in a manner analogous to immunoglobulin promoters in cell_typeB cells . |
| 0.8365 | 1.0000 | 1.0000 | Demonstration of the complete dependence on the Y box in this system suggests that, despite its demonstrated importance in the DRA promoter , the DRA "octamer" does not utilize proteinOTF-2 in a manner analogous to immunoglobulin promoters in B cells . |
| 1.3141 | 10.7640 | 0.9995 | Demonstration of the complete dependence on the Y box in this system suggests that, despite its demonstrated importance in the DRA promoter , the DNADRA "octamer" does not utilize OTF-2 in a manner analogous to immunoglobulin promoters in B cells . |
| Demonstration of the complete dependence on the Y box in this system suggests that, despite its demonstrated importance in the DRA promoter , the DNADRA "octamer" does not utilize OTF-2 in a manner analogous to immunoglobulin promoters in B cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1049 | 30.2923 | 10.7185 | Lipopolysaccharide ( LPS ) potently stimulates human immunodeficiency virus type 1-long terminal repeat ( HIV-1-LTR ) CAT constructs transfected into cell_linemonocyte/macrophage-like cell lines but not a T cell line . |
| 3.5900 | 40.7147 | 20.8924 | Lipopolysaccharide ( LPS ) potently stimulates DNAhuman immunodeficiency virus type 1-long terminal repeat ( HIV-1-LTR ) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line . |
| 2.9170 | 20.2892 | 10.4406 | Lipopolysaccharide ( LPS ) potently stimulates human immunodeficiency virus type 1-long terminal repeat ( HIV-1-LTR ) CAT constructs transfected into monocyte/macrophage-like cell lines but not a cell_lineT cell line . |
| 2.3704 | 10.0251 | 20.3948 | Lipopolysaccharide ( LPS ) potently stimulates DNAhuman immunodeficiency virus type 1-long terminal repeat ( HIV-1-LTR ) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line . |
| 0.8664 | 1.0000 | 0.9799 | Lipopolysaccharide ( LPS ) potently stimulates human immunodeficiency virus type 1-long terminal repeat ( DNAHIV-1-LTR ) CAT constructs transfected into monocyte/macrophage-like cell lines but not a T cell line . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8540 | 10.7740 | 10.9322 | This effect appears to be mediated through the induction of proteinnuclear factor kappa B ( NF-kappa B ). |
| 0.8108 | 0.9998 | 0.9999 | This effect appears to be mediated through the induction of nuclear factor kappa B ( proteinNF-kappa B ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5957 | 10.1248 | 0.9997 | Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from NF-kappa B in U937 and cell_lineTHP-1 cells . |
| 1.5756 | 10.9743 | 1.0000 | Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from proteinNF-kappa B in U937 and THP-1 cells . |
| 0.9018 | 0.9998 | 1.0000 | Electrophoretic mobility shift assays demonstrate that LPS induces a DNA binding activity indistinguishable from NF-kappa B in cell_lineU937 and THP-1 cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.4981 | 30.9065 | 20.4155 | LPS is also shown to dramatically increase HIV-1 production from a cell_linechronically infected monocyte/macrophage-like cloned cell line , U1 , which produces very low levels of HIV-1 at baseline. |
| 0.9313 | 0.9999 | 1.0000 | LPS is also shown to dramatically increase HIV-1 production from a chronically infected monocyte/macrophage-like cloned cell line , cell_lineU1 , which produces very low levels of HIV-1 at baseline. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7743 | 20.6391 | 10.3173 | The stimulation of viral production from this cell line occurs only if these cells are treated with proteingranulocyte/macrophage colony-stimulating factor ( GM-CSF ) before treatment with LPS . |
| 0.9740 | 1.0000 | 1.0000 | The stimulation of viral production from this cell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor ( proteinGM-CSF ) before treatment with LPS . |
| 2.1682 | 20.2160 | 0.9999 | The stimulation of viral production from this cell_linecell line occurs only if these cells are treated with granulocyte/macrophage colony-stimulating factor ( GM-CSF ) before treatment with LPS . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7353 | 10.8801 | 1.0000 | This stimulation of HIV-1 production is correlated with an increase in the level of RNAHIV-1 RNA and and activation of NF-kappa B . |
| 1.5699 | 10.9735 | 1.0000 | This stimulation of HIV-1 production is correlated with an increase in the level of HIV-1 RNA and and activation of proteinNF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9927 | 20.5853 | 10.6203 | LPS is not able to induce HIV-1 production in a cell_linecloned T cell line . |
| LPS is not able to induce HIV-1 production in a cloned cell_lineT cell line . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5075 | 20.3224 | 1.0000 | The suppression of cell_typebasophils measured as whole blood histamine and plasma cortisol concentrations was assessed during 32 hours. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6498 | 10.7203 | 0.9999 | A pharmacodynamic model for cell_typebasophil cell distribution to and from an extravascular compartment describes the effects of MP after both regimens. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4563 | 20.7414 | 1.0000 | A slower initial decline in blood histamine after the divided regimen may be related to incomplete suppression of cell_typebasophil cell return to blood . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5724 | 10.8534 | 0.9999 | 1,25(OH)2D2 production by T lymphocytes and cell_typealveolar macrophages recovered by lavage from normocalcemic patients with tuberculosis. |
| 1.4824 | 10.8130 | 0.9998 | 1,25(OH)2D2 production by cell_typeT lymphocytes and alveolar macrophages recovered by lavage from normocalcemic patients with tuberculosis. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2022 | 20.9224 | 10.4144 | To compare extra-renal 1,25(OH)2D3 production in different types of granulomatous disease , and to identify the cell types responsible, we have evaluated the conversion of 25(OH)D3 in 1,25(OH)2D3 by uncultured cells recovered by bronchoalveolar lavage and cell_typeblood mononuclear cells from normocalcemic patients with sarcoidosis and tuberculosis. |
| 1.6762 | 10.9056 | 0.9999 | To compare extra-renal 1,25(OH)2D3 production in different types of granulomatous disease , and to identify the cell types responsible, we have evaluated the conversion of 25(OH)D3 in 1,25(OH)2D3 by cell_typeuncultured cells recovered by bronchoalveolar lavage and blood mononuclear cells from normocalcemic patients with sarcoidosis and tuberculosis. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9760 | 20.6807 | 10.5607 | 1,25(OH)2D3 was produced both by lavage cells (12/12 tuberculosis patients , 2/6 sarcoidosis patients ) and cell_typeblood mononuclear cells (3/5 tuberculosis patients , 0/3 sarcoidosis patients ) from patients but not controls, but significantly greater amounts were produced by lavage cells from tuberculosis patients than those of sarcoidosis patients (P less than 0.001). |
| 2.4359 | 20.7636 | 0.9999 | 1,25(OH)2D3 was produced both by cell_typelavage cells (12/12 tuberculosis patients , 2/6 sarcoidosis patients ) and blood mononuclear cells (3/5 tuberculosis patients , 0/3 sarcoidosis patients ) from patients but not controls, but significantly greater amounts were produced by lavage cells from tuberculosis patients than those of sarcoidosis patients (P less than 0.001). |
| 2.4120 | 20.5896 | 1.0000 | 1,25(OH)2D3 was produced both by lavage cells (12/12 tuberculosis patients , 2/6 sarcoidosis patients ) and blood mononuclear cells (3/5 tuberculosis patients , 0/3 sarcoidosis patients ) from patients but not controls, but significantly greater amounts were produced by cell_typelavage cells from tuberculosis patients than those of sarcoidosis patients (P less than 0.001). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5192 | 10.7653 | 0.9999 | 1,25(OH)2D3 production by cell_typelavage cells from tuberculosis patients correlated with the number of CD8+ T lymphocytes present but not other cell types. |
| 2.9919 | 10.8478 | 10.8604 | 1,25(OH)2D3 production by lavage cells from tuberculosis patients correlated with the number of cell_typeCD8+ T lymphocytes present but not other cell types. |
| 1,25(OH)2D3 production by lavage cells from tuberculosis patients correlated with the number of CD8+ cell_typeT lymphocytes present but not other cell types. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5759 | 20.2030 | 10.5585 | T lymphocytes appeared to be an important source of 1,25(OH)2D3 production , since purified cell_typeT lymphocytes from all patients with tuberculosis produced 1,25(OH)2D3 , and 1,25(OH)2D3 production by these cells correlated closely with that produced by unseparated lavage cells . |
| 0.8749 | 0.9989 | 0.9999 | cell_typeT lymphocytes appeared to be an important source of 1,25(OH)2D3 production , since purified T lymphocytes from all patients with tuberculosis produced 1,25(OH)2D3 , and 1,25(OH)2D3 production by these cells correlated closely with that produced by unseparated lavage cells . |
| 4.4759 | 30.0689 | 10.7917 | T lymphocytes appeared to be an important source of 1,25(OH)2D3 production , since purified T lymphocytes from all patients with tuberculosis produced 1,25(OH)2D3 , and 1,25(OH)2D3 production by these cells correlated closely with that produced by cell_typeunseparated lavage cells . |
| 1.4376 | 20.9812 | 10.7442 | T lymphocytes appeared to be an important source of 1,25(OH)2D3 production , since cell_typepurified T lymphocytes from all patients with tuberculosis produced 1,25(OH)2D3 , and 1,25(OH)2D3 production by these cells correlated closely with that produced by unseparated lavage cells . |
| T lymphocytes appeared to be an important source of 1,25(OH)2D3 production , since purified T lymphocytes from all patients with tuberculosis produced 1,25(OH)2D3 , and 1,25(OH)2D3 production by these cells correlated closely with that produced by unseparated cell_typelavage cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7795 | 10.3376 | 1.0000 | Because 1,25(OH)2D3 can improve the capacity of cell_typemacrophages to kill mycobacteria , our results support the conclusion that macrophage-lymphocyte interactions , mediated at least in part by 1,25(OH)2D3 , may be an important component of a successful antituberculous immune response . |
| 0.7995 | 1.0000 | 1.0000 | Because 1,25(OH)2D3 can improve the capacity of macrophages to kill mycobacteria , our results support the conclusion that cell_typemacrophage-lymphocyte interactions , mediated at least in part by 1,25(OH)2D3 , may be an important component of a successful antituberculous immune response . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4438 | 10.7272 | 0.9998 | Megakaryocytic and erythrocytic lineages share specific proteintranscription factors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1110 | 20.3901 | 0.9996 | Erythroid-specific genes contain binding sites for NF-E1 (also called GF-1 and Eryf-1 ; refs 1-3 respectively), the principal DNA-binding protein of the cell_typeerythrocytic lineage . |
| 2.1082 | 20.5331 | 1.0000 | Erythroid-specific genes contain binding sites for NF-E1 (also called GF-1 and Eryf-1 ; refs 1-3 respectively), the principal proteinDNA-binding protein of the erythrocytic lineage . |
| 1.7605 | 10.1080 | 1.0000 | Erythroid-specific genes contain binding sites for NF-E1 (also called proteinGF-1 and Eryf-1 ; refs 1-3 respectively), the principal DNA-binding protein of the erythrocytic lineage . |
| 1.4996 | 0.9990 | 10.3009 | DNAErythroid-specific genes contain binding sites for NF-E1 (also called GF-1 and Eryf-1 ; refs 1-3 respectively), the principal DNA-binding protein of the erythrocytic lineage . |
| 0.9163 | 1.0000 | 1.0000 | Erythroid-specific genes contain binding sites for proteinNF-E1 (also called GF-1 and Eryf-1 ; refs 1-3 respectively), the principal DNA-binding protein of the erythrocytic lineage . |
| 0.8936 | 1.0000 | 1.0000 | Erythroid-specific genes contain binding sites for NF-E1 (also called GF-1 and proteinEryf-1 ; refs 1-3 respectively), the principal DNA-binding protein of the erythrocytic lineage . |
| 1.3861 | 10.5673 | 0.9999 | Erythroid-specific genes contain DNAbinding sites for NF-E1 (also called GF-1 and Eryf-1 ; refs 1-3 respectively), the principal DNA-binding protein of the erythrocytic lineage . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0035 | 20.9796 | 0.9998 | NF-E1 expression seems to be restricted to the cell_typeerythrocytic lineage . |
| 0.9690 | 1.0000 | 1.0000 | proteinNF-E1 expression seems to be restricted to the erythrocytic lineage . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7321 | 20.3901 | 10.9059 | A closely related (if not identical) protein is found in both a cell_linehuman megakaryocytic cell line and purified human megakaryocytes ; it binds to promoter regions of two megakaryocytic-specific genes . |
| 3.0493 | 10.8966 | 10.7888 | A closely related (if not identical) protein is found in both a human megakaryocytic cell line and cell_linepurified human megakaryocytes ; it binds to promoter regions of two megakaryocytic-specific genes . |
| 1.4149 | 10.7752 | 0.9999 | A closely related (if not identical) protein is found in both a human megakaryocytic cell line and purified human megakaryocytes ; it binds to DNApromoter regions of two megakaryocytic-specific genes . |
| 1.3761 | 10.7032 | 0.9997 | A closely related (if not identical) protein is found in both a human megakaryocytic cell line and purified human megakaryocytes ; it binds to promoter regions of two DNAmegakaryocytic-specific genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6141 | 20.3457 | 0.9999 | The binding sites and partial proteolysis profile of this protein are indistinguishable from those of the erythroid protein ; also, RNANF-E1 messenger RNA is the same size in both the megakaryocytic and erythroid cell lines . |
| 1.5947 | 10.9736 | 1.0000 | The binding sites and partial proteolysis profile of this protein are indistinguishable from those of the proteinerythroid protein ; also, NF-E1 messenger RNA is the same size in both the megakaryocytic and erythroid cell lines . |
| 1.5301 | 10.8847 | 0.9990 | The binding sites and partial proteolysis profile of this protein are indistinguishable from those of the erythroid protein ; also, proteinNF-E1 messenger RNA is the same size in both the megakaryocytic and erythroid cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3361 | 20.3911 | 1.0000 | Furthermore, point mutations that abolish binding of NF-E1 result in a 70% decrease in the transcriptional activity of a DNAmegakaryocytic-specific promoter . |
| 1.6058 | 10.6285 | 1.0000 | Furthermore, point mutations that abolish binding of proteinNF-E1 result in a 70% decrease in the transcriptional activity of a megakaryocytic-specific promoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2153 | 20.0269 | 0.9999 | We also find that NF-E2 , another trans-acting factor of the cell_typeerythrocytic lineage , is present in megakaryocytes . |
| 2.0719 | 20.2233 | 0.9999 | We also find that NF-E2 , another proteintrans-acting factor of the erythrocytic lineage , is present in megakaryocytes . |
| 1.5489 | 10.8192 | 0.9999 | We also find that NF-E2 , another trans-acting factor of the erythrocytic lineage , is present in cell_linemegakaryocytes . |
| 1.5112 | 10.8735 | 1.0000 | We also find that proteinNF-E2 , another trans-acting factor of the erythrocytic lineage , is present in megakaryocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3231 | 20.4876 | 1.0000 | Transcriptional effects in both lineages might then be mediated in part by the same specific proteintrans-acting factors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.4041 | 30.9917 | 10.9404 | Our data strengthen the idea of a close association between the erythrocytic and the megakaryocytic lineages and could also explain the expression of markers specific to the erythrocytic and megakaryocytic lineages in most cell_lineerythroblastic and megakaryoblastic permanent cell lines . |
| 2.5279 | 20.2556 | 0.9911 | Our data strengthen the idea of a close association between the erythrocytic and the megakaryocytic lineages and could also explain the expression of markers specific to the erythrocytic and megakaryocytic lineages in most cell_lineerythroblastic and megakaryoblastic permanent cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.3852 | 40.1206 | 20.4501 | Transcriptional down-regulation of c-myc expression by protein synthesis -dependent and -independent pathways in a cell_linehuman T lymphoblastic tumor cell line . |
| 2.1035 | 20.9251 | 1.0000 | Transcriptional down-regulation of DNAc-myc expression by protein synthesis -dependent and -independent pathways in a human T lymphoblastic tumor cell line . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9770 | 40.8201 | 10.9613 | We show that in the cell_linehuman T lymphoblastic tumor cell line Molt4 c-myc mRNA and protein expression is down-regulated after exposure to dimethyl sulfoxide , to phorbol myristate acetate , or to the calcium ionophore A23187 , which raises the intracellular calcium concentration . |
| 2.2708 | 10.1575 | 10.7168 | We show that in the human T lymphoblastic tumor cell line RNAMolt4 c-myc mRNA and protein expression is down-regulated after exposure to dimethyl sulfoxide , to phorbol myristate acetate , or to the calcium ionophore A23187 , which raises the intracellular calcium concentration . |
| 1.1705 | 0.9999 | 10.0344 | We show that in the human T lymphoblastic tumor cell line Molt4 RNAc-myc mRNA and protein expression is down-regulated after exposure to dimethyl sulfoxide , to phorbol myristate acetate , or to the calcium ionophore A23187 , which raises the intracellular calcium concentration . |
| We show that in the human T lymphoblastic tumor cell line Molt4 DNAc-myc mRNA and protein expression is down-regulated after exposure to dimethyl sulfoxide , to phorbol myristate acetate , or to the calcium ionophore A23187 , which raises the intracellular calcium concentration . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7343 | 10.4761 | 1.0000 | A block to RNA elongation is largely responsible for decreased DNAc-myc transcription . |
| 1.0901 | 10.1449 | 1.0000 | A block to RNARNA elongation is largely responsible for decreased c-myc transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8088 | 10.3556 | 1.0000 | The calcium ionophore-induced DNAc-myc suppression , however, strictly requires de novo protein synthesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8164 | 10.6164 | 1.0000 | Therefore, two different negative regulatory pathways are involved in DNAc-myc regulation : one which is independent and one which depends on de novo protein synthesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0993 | 10.1897 | 20.2073 | The latter one appears to be mediated by a rapidly proteincalcium -dependent induced gene product . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9868 | 1.0000 | 1.0000 | Oestrogen receptor ( proteinER ) analysis in B-cell chronic lymphocytic leukemia : correlation of biochemical and immunocytochemical methods . |
| 0.9127 | 0.9995 | 1.0000 | proteinOestrogen receptor ( ER ) analysis in B-cell chronic lymphocytic leukemia : correlation of biochemical and immunocytochemical methods . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7104 | 20.4252 | 10.4474 | Oestrogen receptors ( ER ) are present in cell_typeneoplastic lymphoid cells and have been considered a physiological marker of growth rate or differentiation. |
| 0.9774 | 1.0000 | 1.0000 | Oestrogen receptors ( proteinER ) are present in neoplastic lymphoid cells and have been considered a physiological marker of growth rate or differentiation. |
| 0.8775 | 0.9992 | 1.0000 | proteinOestrogen receptors ( ER ) are present in neoplastic lymphoid cells and have been considered a physiological marker of growth rate or differentiation. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8619 | 10.7319 | 1.0000 | Until now, proteinER status has been assessed using a steroid binding assay ( SBA ) which has many inherent problems. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8297 | 10.3127 | 1.0000 | Recently, the development of monoclonal antibodies directed against proteinER has been applied to the study of breast carcinomas and results obtained show good correlation with the quantitative SBA . |
| 2.5298 | 20.4952 | 1.0000 | Recently, the development of proteinmonoclonal antibodies directed against ER has been applied to the study of breast carcinomas and results obtained show good correlation with the quantitative SBA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4703 | 10.1450 | 0.9998 | In 30 of these cases ER enzyme immunoassay ( proteinER -EIA ) was also performed. |
| 0.5429 | 0.9997 | 1.0000 | In 30 of these cases ER enzyme immunoassay ( proteinER -EIA ) was also performed. |
| In 30 of these cases proteinER enzyme immunoassay ( ER -EIA ) was also performed. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4645 | 20.8224 | 10.6562 | Cultured MCF-7 cells , derived from a pleural effusion of a breast cancer patient , known to contain high levels of ER were used as a positive control (40-48% cell_typeER positive cells by immunocytochemistry; 200 fmol/mg protein by EIA). |
| 1.7282 | 0.9987 | 10.7322 | cell_lineCultured MCF-7 cells , derived from a pleural effusion of a breast cancer patient , known to contain high levels of ER were used as a positive control (40-48% ER positive cells by immunocytochemistry; 200 fmol/mg protein by EIA). |
| 1.7110 | 10.1990 | 1.0000 | Cultured MCF-7 cells , derived from a pleural effusion of a breast cancer patient , known to contain high levels of proteinER were used as a positive control (40-48% ER positive cells by immunocytochemistry; 200 fmol/mg protein by EIA). |
| 1.6487 | 10.6102 | 0.9951 | Cultured MCF-7 cells , derived from a pleural effusion of a breast cancer patient , known to contain high levels of ER were used as a positive control (40-48% proteinER positive cells by immunocytochemistry; 200 fmol/mg protein by EIA). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8208 | 10.5113 | 1.0000 | All of the CLL cases except two (96%) were negative for proteinER (less than 1% staining; less than 4 fmol/mg protein). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9389 | 1.0000 | 1.0000 | The two positive cases expressed granular proteinER staining over the nucleus (9.2 and 12.1% positive cells) and were positive by EIA and SBA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7549 | 10.3157 | 1.0000 | It is concluded that (i) patients with CLL rarely express proteinER and (ii) immunocytochemical staining of cytospin preparations is a valid technique for the measurement of ER . |
| 1.7013 | 10.7121 | 1.0000 | It is concluded that (i) patients with CLL rarely express ER and (ii) immunocytochemical staining of cytospin preparations is a valid technique for the measurement of proteinER . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9845 | 30.3261 | 10.5819 | Type-II estrogen binding sites in a cell_linelymphoblastoid cell line and growth-inhibitory effect of estrogen , anti-estrogen and bioflavonoids . |
| 1.6171 | 0.9974 | 10.5170 | proteinType-II estrogen binding sites in a lymphoblastoid cell line and growth-inhibitory effect of estrogen , anti-estrogen and bioflavonoids . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5086 | 0.9971 | 10.0639 | proteinType-II estrogen -binding sites ( type-II EBS ) have been demonstrated in the human lymphoblastoid cell line IM-9 using a whole-cell assay with (6,7-3H) estradiol ( 3H-E2 ) as tracer. |
| 1.4651 | 10.3773 | 1.0000 | Type-II estrogen -binding sites ( proteintype-II EBS ) have been demonstrated in the human lymphoblastoid cell line IM-9 using a whole-cell assay with (6,7-3H) estradiol ( 3H-E2 ) as tracer. |
| 7.1012 | 30.7601 | 20.8467 | Type-II estrogen -binding sites ( type-II EBS ) have been demonstrated in the cell_linehuman lymphoblastoid cell line IM-9 using a whole-cell assay with (6,7-3H) estradiol ( 3H-E2 ) as tracer. |
| Type-II estrogen -binding sites ( type-II EBS ) have been demonstrated in the human cell_linelymphoblastoid cell line IM-9 using a whole-cell assay with (6,7-3H) estradiol ( 3H-E2 ) as tracer. | |||
| Type-II estrogen -binding sites ( type-II EBS ) have been demonstrated in the human lymphoblastoid cell line cell_lineIM-9 using a whole-cell assay with (6,7-3H) estradiol ( 3H-E2 ) as tracer. | |||
| Type-II estrogen -binding sites ( type-II EBS ) have been demonstrated in the cell_linehuman lymphoblastoid cell line IM-9 using a whole-cell assay with (6,7-3H) estradiol ( 3H-E2 ) as tracer. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5300 | 10.7695 | 0.9999 | Competition analysis showed that the anti-estrogen tamoxifen and the flavonoids quercetin and rutin competed for (3H)-E2 binding to DNAtype-II EBS . |
| 0.8303 | 1.0000 | 1.0000 | Competition analysis showed that the anti-estrogen tamoxifen and the flavonoids quercetin and rutin competed for (3H)-E2 binding to type-II DNAEBS . |
| Competition analysis showed that the anti-estrogen tamoxifen and the flavonoids quercetin and rutin competed for (3H)-E2 binding to proteintype-II EBS . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7734 | 20.9392 | 1.0000 | The relative binding affinity of quercetin , rutin , DES and TAM for DNAtype-II EBS correlated well with their potency as cell growth inhibitors . |
| 0.5376 | 1.0000 | 1.0000 | The relative binding affinity of quercetin , rutin , DES and TAM for type-II DNAEBS correlated well with their potency as cell growth inhibitors . |
| The relative binding affinity of quercetin , rutin , DES and TAM for proteintype-II EBS correlated well with their potency as cell growth inhibitors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2237 | 20.8084 | 1.0000 | Moreover, hesperidin, a flavonoid which does not bind to DNAtype-II EBS , was ineffective in inhibiting cell growth . |
| 0.9568 | 1.0000 | 1.0000 | Moreover, hesperidin, a flavonoid which does not bind to type-II DNAEBS , was ineffective in inhibiting cell growth . |
| Moreover, hesperidin, a flavonoid which does not bind to proteintype-II EBS , was ineffective in inhibiting cell growth . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6554 | 10.9137 | 0.9999 | Our results suggest that high estrogen and anti-estrogen concentrations and flavonoids may regulate cell_lineIM-9 cell growth through a common mechanism involving a binding interaction with type-II EBS . |
| Our results suggest that high estrogen and anti-estrogen concentrations and flavonoids may regulate cell_lineIM-9 cell growth through a common mechanism involving a binding interaction with type-II EBS . | |||
| Our results suggest that high estrogen and anti-estrogen concentrations and flavonoids may regulate IM-9 cell growth through a common mechanism involving a binding interaction with proteintype-II EBS . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2023 | 10.8709 | 10.5047 | [ Glucocorticoid receptors in cell_typeperipheral blood lymphocytes of patients with bronchial asthma ] |
| 1.5233 | 10.3329 | 0.9999 | [ proteinGlucocorticoid receptors in peripheral blood lymphocytes of patients with bronchial asthma ] |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0228 | 20.9290 | 10.7917 | Quantitation of glucocorticoid receptors ( GCR ) and the study of their affinity for glucocorticosteroids ( GCS ) were made in cell_typeperipheral blood lymphocytes of bronchial asthma ( BA ) patients in consideration of GCR treatment and serum levels of endogenous cortisol . |
| 2.3547 | 20.5809 | 1.0000 | Quantitation of proteinglucocorticoid receptors ( GCR ) and the study of their affinity for glucocorticosteroids ( GCS ) were made in peripheral blood lymphocytes of bronchial asthma ( BA ) patients in consideration of GCR treatment and serum levels of endogenous cortisol . |
| 1.7889 | 10.0622 | 1.0000 | Quantitation of glucocorticoid receptors ( GCR ) and the study of their affinity for glucocorticosteroids ( GCS ) were made in peripheral blood lymphocytes of bronchial asthma ( BA ) patients in consideration of proteinGCR treatment and serum levels of endogenous cortisol . |
| 0.9585 | 1.0000 | 1.0000 | Quantitation of glucocorticoid receptors ( proteinGCR ) and the study of their affinity for glucocorticosteroids ( GCS ) were made in peripheral blood lymphocytes of bronchial asthma ( BA ) patients in consideration of GCR treatment and serum levels of endogenous cortisol . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7279 | 10.2900 | 1.0000 | It is stated that proteinGCR of healthy controls and GCS -untreated patients outnumbered those of cortisol-dependent BA patients on hormone therapy . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9462 | 1.0000 | 1.0000 | Following discontinuation of glucocorticoid drugs proteinGCR count in cortisol -dependent BA tends to rise. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6714 | 10.3697 | 1.0000 | Endogenous cortisol has no effect on proteinGCR level estimated by 3H-triamcinolone acetonide . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4709 | 10.8609 | 10.3209 | Two proteinglucocorticoid binding sites on the human glucocorticoid receptor . |
| 2.4468 | 10.9405 | 10.4753 | Two glucocorticoid binding sites on the proteinhuman glucocorticoid receptor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4802 | 10.8721 | 0.9999 | Glucocorticoids are known to have a lytic effect in cell_typeleukemic cells via interactions with the glucocorticoid receptor ( GR ). |
| 1.4559 | 10.8781 | 1.0000 | Glucocorticoids are known to have a lytic effect in leukemic cells via interactions with the proteinglucocorticoid receptor ( GR ). |
| 0.9544 | 1.0000 | 1.0000 | Glucocorticoids are known to have a lytic effect in leukemic cells via interactions with the glucocorticoid receptor ( proteinGR ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7209 | 10.4472 | 1.0000 | Cortisol and various synthetic glucocorticoids bind to the proteinGR with one-site kinetics . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5535 | 20.6458 | 10.1656 | Cortivazol ( CVZ ) is a unique, high potency synthetic glucocorticoid , which has a phenylpyrazol fused to the A-ring of the steroid nucleus and displays binding consistent with two or more sites in the cytosol from CEM C7 cells (a cell_linehuman acute lymphoblastic T-cell line ). |
| 2.1554 | 20.4274 | 10.5657 | Cortivazol ( CVZ ) is a unique, high potency synthetic glucocorticoid , which has a phenylpyrazol fused to the A-ring of the steroid nucleus and displays binding consistent with two or more sites in the cytosol from cell_lineCEM C7 cells (a human acute lymphoblastic T-cell line ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.4805 | 0.9999 | 1.0000 | It has previously been shown that the lower affinity class of DNAsites are similar in affinity and site molarity to those recognized by dexamethasone . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3487 | 10.7703 | 10.2326 | The proteinhigher affinity sites bind CVZ with 20- to 50-fold greater affinity , consistent with CVZ 's enhanced biological effects . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8061 | 20.2001 | 10.6484 | In mutant leukemic cells resistant to the lytic effects of dexamethasone , CVZ both lyses the cells and recognizes a single class of sites similar to the high affinity site in cell_lineCEM C7 cells . |
| 4.3719 | 20.7891 | 10.9702 | In mutant leukemic cells resistant to the lytic effects of dexamethasone , CVZ both lyses the cells and recognizes a single class of sites similar to the DNAhigh affinity site in CEM C7 cells . |
| 2.2869 | 10.9013 | 10.0783 | In cell_linemutant leukemic cells resistant to the lytic effects of dexamethasone , CVZ both lyses the cells and recognizes a single class of sites similar to the high affinity site in CEM C7 cells . |
| In mutant cell_typeleukemic cells resistant to the lytic effects of dexamethasone , CVZ both lyses the cells and recognizes a single class of sites similar to the high affinity site in CEM C7 cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.5370 | 30.3372 | 20.6201 | We have carried out experiments to define the nature of the DNAhigher affinity CVZ binding site . |
| 0.7909 | 1.0000 | 0.9800 | We have carried out experiments to define the nature of the higher affinity proteinCVZ binding site . |
| We have carried out experiments to define the nature of the proteinhigher affinity CVZ binding site . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4132 | 20.8115 | 0.9998 | We now show that: 1) CVZ has more than one binding site in a second, independent, cell_lineB-cell line , IM-9 ; 2) the antiglucocorticoid RU 38486 is able to block both CVZ 's higher and lower affinity sites; 3) all of CVZ 's binding sites are on a protein immunologically indistinguishable from the human GR ; and 4) freshly isolated clones of CVZ -resistant cells have lost all binding sites for CVZ . |
| 0.9566 | 1.0000 | 1.0000 | We now show that: 1) CVZ has more than one binding site in a second, independent, B-cell line , cell_lineIM-9 ; 2) the antiglucocorticoid RU 38486 is able to block both CVZ 's higher and lower affinity sites; 3) all of CVZ 's binding sites are on a protein immunologically indistinguishable from the human GR ; and 4) freshly isolated clones of CVZ -resistant cells have lost all binding sites for CVZ . |
| 2.3829 | 20.9520 | 1.0000 | We now show that: 1) CVZ has more than one binding site in a second, independent, B-cell line , IM-9 ; 2) the antiglucocorticoid RU 38486 is able to block both CVZ 's higher and lower affinity sites; 3) all of CVZ 's binding sites are on a protein immunologically indistinguishable from the proteinhuman GR ; and 4) freshly isolated clones of CVZ -resistant cells have lost all binding sites for CVZ . |
| 2.1436 | 20.2756 | 1.0000 | We now show that: 1) CVZ has more than one binding site in a second, independent, B-cell line , IM-9 ; 2) the antiglucocorticoid RU 38486 is able to block both CVZ 's higher and lower affinity sites; 3) all of CVZ 's DNAbinding sites are on a protein immunologically indistinguishable from the human GR ; and 4) freshly isolated clones of CVZ -resistant cells have lost all binding sites for CVZ . |
| 1.7198 | 30.6502 | 0.9999 | We now show that: 1) CVZ has more than one binding site in a second, independent, B-cell line , IM-9 ; 2) the antiglucocorticoid RU 38486 is able to block both CVZ 's higher and lower affinity sites; 3) all of CVZ 's binding sites are on a protein immunologically indistinguishable from the human GR ; and 4) freshly isolated clones of cell_lineCVZ -resistant cells have lost all binding sites for CVZ . |
| 1.5093 | 20.7872 | 0.9999 | We now show that: 1) CVZ has more than one DNAbinding site in a second, independent, B-cell line , IM-9 ; 2) the antiglucocorticoid RU 38486 is able to block both CVZ 's higher and lower affinity sites; 3) all of CVZ 's binding sites are on a protein immunologically indistinguishable from the human GR ; and 4) freshly isolated clones of CVZ -resistant cells have lost all binding sites for CVZ . |
| 1.4357 | 30.7434 | 1.0000 | We now show that: 1) CVZ has more than one binding site in a second, independent, B-cell line , IM-9 ; 2) the antiglucocorticoid RU 38486 is able to block both CVZ 's higher and lower affinity sites; 3) all of CVZ 's binding sites are on a protein immunologically indistinguishable from the human GR ; and 4) freshly isolated clones of CVZ -resistant cells have lost all DNAbinding sites for CVZ . |
| We now show that: 1) CVZ has more than one binding site in a second, independent, B-cell line , IM-9 ; 2) the antiglucocorticoid RU 38486 is able to block both CVZ 's higher and lower affinity sites; 3) all of CVZ 's binding sites are on a protein immunologically indistinguishable from the human proteinGR ; and 4) freshly isolated clones of CVZ -resistant cells have lost all binding sites for CVZ . | |||
| We now show that: 1) CVZ has more than one binding site in a second, independent, B-cell line , IM-9 ; 2) the antiglucocorticoid RU 38486 is able to block both CVZ 's higher and lower affinity sites; 3) all of proteinCVZ 's binding sites are on a protein immunologically indistinguishable from the human GR ; and 4) freshly isolated clones of CVZ -resistant cells have lost all binding sites for CVZ . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6604 | 10.6243 | 10.6650 | These data indicate that CVZ is recognizing two DNAglucocorticoid binding sites on the human GR or a protein very similar to it. |
| 1.5290 | 10.2364 | 1.0000 | These data indicate that CVZ is recognizing two glucocorticoid binding sites on the proteinhuman GR or a protein very similar to it. |
| These data indicate that CVZ is recognizing two glucocorticoid binding sites on the human proteinGR or a protein very similar to it. | |||
| These data indicate that CVZ is recognizing two proteinglucocorticoid binding sites on the human GR or a protein very similar to it. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9999 | 10.4534 | 10.5885 | Retroviral mediated transfer and expression of exogenous genes in cell_typeprimary lymphoid cells : assaying for a viral transactivator activity in normal and malignant cells . |
| 2.1652 | 20.5324 | 0.9999 | Retroviral mediated transfer and expression of DNAexogenous genes in primary lymphoid cells : assaying for a viral transactivator activity in normal and malignant cells . |
| 2.2050 | 20.1569 | 1.0000 | Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells : assaying for a proteinviral transactivator activity in normal and malignant cells . |
| Retroviral mediated transfer and expression of exogenous genes in primary lymphoid cells : assaying for a viral proteintransactivator activity in normal and malignant cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3789 | 20.3098 | 0.9999 | In this report we describe the use of recombinant retroviruses to characterize the activity of an DNAexogenous promoter in primary cells obtained from patients with lymphoproliferative disorders . |
| 1.6514 | 10.6169 | 0.9999 | In this report we describe the use of recombinant retroviruses to characterize the activity of an exogenous promoter in cell_typeprimary cells obtained from patients with lymphoproliferative disorders . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1955 | 30.2649 | 10.5756 | The infection of a variety of cultured and primary lymphoid cells with a recombinant retrovirus containing a DNAhistone promoter-driven beta-galactosidase gene is shown to result in the expression of beta-galactosidase in 50% to 100% of the cells. |
| 2.5514 | 20.7471 | 10.7049 | The infection of a variety of cultured and cell_typeprimary lymphoid cells with a recombinant retrovirus containing a histone promoter-driven beta-galactosidase gene is shown to result in the expression of beta-galactosidase in 50% to 100% of the cells. |
| 1.6549 | 10.2455 | 1.0000 | The infection of a variety of cultured and primary lymphoid cells with a recombinant retrovirus containing a histone promoter-driven beta-galactosidase gene is shown to result in the expression of proteinbeta-galactosidase in 50% to 100% of the cells. |
| 0.9459 | 1.0000 | 0.9942 | The infection of a variety of cultured and primary lymphoid cells with a recombinant retrovirus containing a histone promoter-driven proteinbeta-galactosidase gene is shown to result in the expression of beta-galactosidase in 50% to 100% of the cells. |
| The infection of a variety of cultured and primary lymphoid cells with a recombinant retrovirus containing a proteinhistone promoter-driven beta-galactosidase gene is shown to result in the expression of beta-galactosidase in 50% to 100% of the cells. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7981 | 20.2875 | 10.6756 | A similar infection with a recombinant retrovirus containing the beta-galactosidase gene with an DNAadenovirus E2 promoter , results in beta-galactosidase activity in a limited number of cultured and primary cells . |
| 2.2161 | 20.4392 | 1.0000 | A similar infection with a recombinant retrovirus containing the DNAbeta-galactosidase gene with an adenovirus E2 promoter , results in beta-galactosidase activity in a limited number of cultured and primary cells . |
| 2.1101 | 20.3863 | 0.9885 | A similar infection with a recombinant retrovirus containing the proteinbeta-galactosidase gene with an adenovirus E2 promoter , results in beta-galactosidase activity in a limited number of cultured and primary cells . |
| 0.9315 | 1.0000 | 1.0000 | A similar infection with a recombinant retrovirus containing the beta-galactosidase gene with an adenovirus E2 promoter , results in proteinbeta-galactosidase activity in a limited number of cultured and primary cells . |
| A similar infection with a recombinant retrovirus containing the beta-galactosidase gene with an adenovirus E2 promoter , results in beta-galactosidase activity in a limited number of cell_linecultured and primary cells . | |||
| A similar infection with a recombinant retrovirus containing the beta-galactosidase gene with an adenovirus E2 promoter , results in beta-galactosidase activity in a limited number of cultured and cell_typeprimary cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8732 | 30.0271 | 10.6495 | Since the adenovirus E2 promoter has been well characterized and is known to be regulated by transactivators encoded by many viruses , the activity of this promoter in specific cell types is discussed in reference to both the biology of the cell and the possible presence of as yet undetected proteinviral gene products . |
| 2.3367 | 20.7751 | 10.4161 | Since the DNAadenovirus E2 promoter has been well characterized and is known to be regulated by transactivators encoded by many viruses , the activity of this promoter in specific cell types is discussed in reference to both the biology of the cell and the possible presence of as yet undetected viral gene products . |
| 1.6793 | 10.2081 | 1.0000 | Since the adenovirus E2 promoter has been well characterized and is known to be regulated by proteintransactivators encoded by many viruses , the activity of this promoter in specific cell types is discussed in reference to both the biology of the cell and the possible presence of as yet undetected viral gene products . |
| 0.8230 | 1.0000 | 1.0000 | Since the adenovirus E2 promoter has been well characterized and is known to be regulated by transactivators encoded by many viruses , the activity of this DNApromoter in specific cell types is discussed in reference to both the biology of the cell and the possible presence of as yet undetected viral gene products . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8110 | 10.6545 | 1.0000 | Concentration of receptors of hormonal form of 1,25(OH)2D3 was found to be minimal in cell_typelymphocytes under conditions of chronic kidney insufficiency , while their expression, after the dioxyvit action, was detected only in patients with glomerulonephritis . |
| 1.7380 | 10.7048 | 1.0000 | Concentration of proteinreceptors of hormonal form of 1,25(OH)2D3 was found to be minimal in lymphocytes under conditions of chronic kidney insufficiency , while their expression, after the dioxyvit action, was detected only in patients with glomerulonephritis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6033 | 10.6049 | 1.0000 | [The role of glucocorticoid receptors and proteinHLA antigens in the pathogenesis of Cushing's syndrome ] |
| 1.4745 | 10.9862 | 1.0000 | [The role of proteinglucocorticoid receptors and HLA antigens in the pathogenesis of Cushing's syndrome ] |
| [The role of glucocorticoid receptors and HLA antigens in the pathogenesis of proteinCushing's syndrome ] | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6368 | 10.7093 | 1.0000 | Lymphocytic levels of proteinglucocorticoid receptors were evaluated in 114 patients suffering from Icenko- Cushing's syndrome . |
| Lymphocytic levels of glucocorticoid receptors were evaluated in 114 patients suffering from Icenko- proteinCushing's syndrome . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5565 | 10.7971 | 1.0000 | Incidence of proteinHLA antigens was determined in 94 of them. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8530 | 1.0000 | 1.0000 | A significant rise of proteinA10 and B27 antigen incidence compared to that in normal subjects allows these antigens to be considered genetic markers of Icenko- Cushing's syndrome . |
| 0.9448 | 1.0000 | 1.0000 | A significant rise of A10 and proteinB27 antigen incidence compared to that in normal subjects allows these antigens to be considered genetic markers of Icenko- Cushing's syndrome . |
| 0.9218 | 1.0000 | 1.0000 | A significant rise of A10 and B27 antigen incidence compared to that in normal subjects allows these proteinantigens to be considered genetic markers of Icenko- Cushing's syndrome . |
| A significant rise of A10 and proteinB27 antigen incidence compared to that in normal subjects allows these antigens to be considered genetic markers of Icenko- Cushing's syndrome . | |||
| A significant rise of A10 and B27 antigen incidence compared to that in normal subjects allows these antigens to be considered genetic markers of Icenko- proteinCushing's syndrome . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4613 | 20.7084 | 1.0000 | The levels of proteinglucocorticoid receptors in lymphocytes of the patients are lower than in normal subjects both in the active stage of the disease and following bilateral total adrenalectomy . |
| 1.8585 | 10.3694 | 1.0000 | The levels of glucocorticoid receptors in cell_typelymphocytes of the patients are lower than in normal subjects both in the active stage of the disease and following bilateral total adrenalectomy . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4364 | 20.2122 | 1.0000 | The patients carrying proteinB27 antigen had lymphocytic receptor concentrations under the levels of such in patients free of the antigen carriage. |
| 1.7399 | 10.4249 | 1.0000 | The patients carrying B27 antigen had proteinlymphocytic receptor concentrations under the levels of such in patients free of the antigen carriage. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1358 | 20.4257 | 0.9999 | Antigen B27 seems to be a cause of lower levels of proteinglucocorticoid receptors in blood lymphocytes . |
| 1.4626 | 10.9658 | 0.9997 | Antigen B27 seems to be a cause of lower levels of glucocorticoid receptors in cell_typeblood lymphocytes . |
| 0.8584 | 0.9997 | 1.0000 | proteinAntigen B27 seems to be a cause of lower levels of glucocorticoid receptors in blood lymphocytes . |
| 0.9098 | 1.0000 | 1.0000 | Antigen proteinB27 seems to be a cause of lower levels of glucocorticoid receptors in blood lymphocytes . |
| Antigen B27 seems to be a cause of lower levels of glucocorticoid receptors in blood cell_typelymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.8007 | 30.8358 | 20.9915 | Effects of 1 alpha, 25-dihydroxyvitamin D3 on the cell_linehuman chronic myelogenous leukemia cell line RWLeu-4 . |
| 0.9102 | 0.9985 | 0.9993 | Effects of 1 alpha, 25-dihydroxyvitamin D3 on the human chronic myelogenous leukemia cell line cell_lineRWLeu-4 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.8081 | 40.5869 | 10.5465 | The effects of 1 alpha, 25-dihydroxyvitamin D3 ( VD3 ) on proliferation , differentiation , and macromolecular synthesis in the new cell_linePhiladelphia chromosome-positive chronic myelogenous leukemia cell line , RWLeu-4 , were investigated. |
| 0.9112 | 0.9999 | 1.0000 | The effects of 1 alpha, 25-dihydroxyvitamin D3 ( VD3 ) on proliferation , differentiation , and macromolecular synthesis in the new Philadelphia chromosome-positive chronic myelogenous leukemia cell line , cell_lineRWLeu-4 , were investigated. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5879 | 10.6688 | 0.9999 | Treatment of cell_lineRWLeu-4 cells with VD3 induced 24R-hydroxylase activity , a marker of vitamin D3 responsiveness in many tissues. |
| 0.9593 | 1.0000 | 1.0000 | Treatment of RWLeu-4 cells with VD3 induced protein24R-hydroxylase activity , a marker of vitamin D3 responsiveness in many tissues. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6394 | 20.0043 | 1.0000 | Exposure of cell_lineRWLeu-4 cells to VD3 also inhibited proliferation and DNA synthesis with a 50% effective dose of 3.5-10 nM within 72 h; in addition, protein and RNA synthesis were inhibited by VD3 treatment . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0361 | 20.4045 | 10.6848 | Exposure of RWLeu-4 cells to 5 nM VD3 for 72 h caused 50% of the cells to differentiate into cell_typemacrophage/monocyte type cells as judged by nitroblue tetrazolium staining and adherence to plastic. |
| 2.4311 | 20.8105 | 0.9999 | Exposure of cell_lineRWLeu-4 cells to 5 nM VD3 for 72 h caused 50% of the cells to differentiate into macrophage/monocyte type cells as judged by nitroblue tetrazolium staining and adherence to plastic. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8477 | 30.2432 | 10.3347 | Progressive expression of proteincell surface maturation-specific antigens of the monocyte/macrophage lineage was induced by treatment of RWLeu-4 cells with VD3 for 24 to 72 h at doses that inhibited cellular proliferation . |
| 2.2745 | 20.7661 | 0.9999 | Progressive expression of cell surface maturation-specific antigens of the monocyte/macrophage lineage was induced by treatment of cell_lineRWLeu-4 cells with VD3 for 24 to 72 h at doses that inhibited cellular proliferation . |
| 2.1003 | 20.4168 | 0.9999 | Progressive expression of cell surface maturation-specific antigens of the cell_typemonocyte/macrophage lineage was induced by treatment of RWLeu-4 cells with VD3 for 24 to 72 h at doses that inhibited cellular proliferation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5708 | 20.3925 | 1.0000 | c-myc RNA , which is constitutively expressed in cell_lineRWLeu-4 cells , increased after 0.5 h of treatment with 50 nM VD3 and then rapidly decreased to barely detectable levels after 4 h of treatment. |
| 0.9515 | 0.9996 | 1.0000 | RNAc-myc RNA , which is constitutively expressed in RWLeu-4 cells , increased after 0.5 h of treatment with 50 nM VD3 and then rapidly decreased to barely detectable levels after 4 h of treatment. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7393 | 20.5437 | 10.4045 | Finally, the in vitro tyrosine kinase activity associated with the proteinp210bcr-abl oncogene product was decreased approximately 50% by VD3 treatment . |
| 1.4955 | 10.9370 | 0.9996 | Finally, the in vitro proteintyrosine kinase activity associated with the p210bcr-abl oncogene product was decreased approximately 50% by VD3 treatment . |
| Finally, the in vitro tyrosine kinase activity associated with the DNAp210bcr-abl oncogene product was decreased approximately 50% by VD3 treatment . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3419 | 20.0552 | 1.0000 | Because of the presence of a functional proteinreceptor-effector system for VD3 and multiple biological responses to the hormone, these cells provide a unique model system with which to probe the specific effects of VD3 on cell growth and differentiation in chronic myelogenous leukemia . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8004 | 30.0329 | 10.6919 | A new member of the leucine zipper class of proteins that binds to the DNAHLA DR alpha promoter . |
| 2.3373 | 20.5182 | 10.2914 | A new member of the proteinleucine zipper class of proteins that binds to the HLA DR alpha promoter . |
| A new member of the proteinleucine zipper class of proteins that binds to the HLA DR alpha promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.8164 | 30.9145 | 20.6614 | Several mutants derived from cell_linetransformed human B cell lines are defective in expressing major histocompatibility complex (MHC) class II genes . |
| 5.2392 | 30.1913 | 20.8714 | Several mutants derived from transformed human B cell lines are defective in expressing DNAmajor histocompatibility complex (MHC) class II genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.4167 | 30.6367 | 10.6858 | The failure to express a class II gene in at least one such mutant line has been mapped to the DNAMHC class II X box , a conserved transcriptional element in the promoter region . |
| 3.2962 | 30.1420 | 10.2113 | The failure to express a class II gene in at least one such mutant line has been mapped to the MHC class II X box , a DNAconserved transcriptional element in the promoter region . |
| 3.2487 | 30.4832 | 10.6026 | The failure to express a DNAclass II gene in at least one such mutant line has been mapped to the MHC class II X box , a conserved transcriptional element in the promoter region . |
| 1.9967 | 20.8303 | 0.9997 | The failure to express a class II gene in at least one such mutant line has been mapped to the MHC class II X box , a conserved transcriptional element in the DNApromoter region . |
| 1.9142 | 20.3058 | 0.9999 | The failure to express a class II gene in at least one such cell_linemutant line has been mapped to the MHC class II X box , a conserved transcriptional element in the promoter region . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1583 | 30.5229 | 10.6772 | A complementary DNA encoding a DNA-binding protein ( human X box binding protein , hXBP-1 ) whose target is the DNAhuman DR alpha X box and the 3' flanking region has now been cloned. |
| 3.9420 | 20.3181 | 10.9409 | A complementary DNA encoding a DNA-binding protein ( proteinhuman X box binding protein , hXBP-1 ) whose target is the human DR alpha X box and the 3' flanking region has now been cloned. |
| 3.9395 | 30.3460 | 10.7807 | A complementary DNA encoding a DNA-binding protein ( human X box binding protein , hXBP-1 ) whose target is the human DR alpha X box and the DNA3' flanking region has now been cloned. |
| 1.3940 | 10.6813 | 0.9999 | A DNAcomplementary DNA encoding a DNA-binding protein ( human X box binding protein , hXBP-1 ) whose target is the human DR alpha X box and the 3' flanking region has now been cloned. |
| 1.3274 | 10.8290 | 0.9999 | A complementary DNA encoding a proteinDNA-binding protein ( human X box binding protein , hXBP-1 ) whose target is the human DR alpha X box and the 3' flanking region has now been cloned. |
| 0.9674 | 1.0000 | 1.0000 | A complementary DNA encoding a DNA-binding protein ( human X box binding protein , proteinhXBP-1 ) whose target is the human DR alpha X box and the 3' flanking region has now been cloned. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9574 | 20.9463 | 10.7475 | This complementary DNA encoded a protein with structural similarities to the proteinc-jun proto-oncogene product , and its target sequence was closely related to the palindromic target sequence of c-jun . |
| 2.8389 | 20.8250 | 10.7318 | This complementary DNA encoded a protein with structural similarities to the c-jun proto-oncogene product , and its target sequence was closely related to the DNApalindromic target sequence of c-jun . |
| 1.5292 | 10.9391 | 1.0000 | This DNAcomplementary DNA encoded a protein with structural similarities to the c-jun proto-oncogene product , and its target sequence was closely related to the palindromic target sequence of c-jun . |
| 0.8826 | 0.9999 | 1.0000 | This complementary DNA encoded a protein with structural similarities to the c-jun proto-oncogene product , and its target sequence was closely related to the palindromic target sequence of DNAc-jun . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4255 | 20.2047 | 10.9077 | Mutation of the DNAhXBP-1 DNA target sequence decreased DR alpha promoter activity in vivo. |
| 1.4608 | 10.8634 | 0.9989 | Mutation of the hXBP-1 DNA target sequence decreased DNADR alpha promoter activity in vivo. |
| 1.2490 | 10.4986 | 0.9977 | Mutation of the proteinhXBP-1 DNA target sequence decreased DR alpha promoter activity in vivo. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9111 | 20.1961 | 1.0000 | These studies suggest that the proteinhXBP-1 protein acts as a transcription factor in B cells . |
| 1.8741 | 20.3503 | 0.9902 | These studies suggest that the proteinhXBP-1 protein acts as a transcription factor in B cells . |
| 1.4723 | 10.8276 | 0.9996 | These studies suggest that the hXBP-1 protein acts as a transcription factor in cell_typeB cells . |
| 1.3699 | 10.9898 | 0.9999 | These studies suggest that the hXBP-1 protein acts as a proteintranscription factor in B cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6447 | 20.7117 | 10.1616 | Absent or greatly diminished type I aldosterone receptors in cell_typeperipheral mononuclear leucocytes have been recently demonstrated and explain the lack of response to mineralocorticoids . |
| 3.8374 | 20.7797 | 10.3985 | Absent or greatly diminished proteintype I aldosterone receptors in peripheral mononuclear leucocytes have been recently demonstrated and explain the lack of response to mineralocorticoids . |
| Absent or greatly diminished type proteinI aldosterone receptors in peripheral mononuclear leucocytes have been recently demonstrated and explain the lack of response to mineralocorticoids . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7837 | 10.8358 | 1.0000 | In three families the autosomal recessive form was characterized by proteinnormal receptor as well as hormone data in both parents, while in one family receptor levels in both parents were greatly reduced, but hormone levels were normal. |
| 0.9285 | 1.0000 | 1.0000 | In three families the autosomal recessive form was characterized by normal receptor as well as hormone data in both parents, while in one family proteinreceptor levels in both parents were greatly reduced, but hormone levels were normal. |
| 0.5145 | 1.0000 | 1.0000 | In three families the autosomal recessive form was characterized by normal proteinreceptor as well as hormone data in both parents, while in one family receptor levels in both parents were greatly reduced, but hormone levels were normal. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3633 | 30.4888 | 0.9999 | In the four families with an autosomal dominant mode of transmission there was always one parent with reduced receptor binding in cell_typeperipheral mononuclear leucocytes and elevated serum hormone levels . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6070 | 20.7131 | 10.5856 | Perceived social support and tumor estrogen/progesterone receptor status as predictors of cell_typenatural killer cell activity in breast cancer patients . |
| 0.7048 | 0.9998 | 1.0000 | Perceived social support and tumor proteinestrogen/progesterone receptor status as predictors of natural killer cell activity in breast cancer patients . |
| 2.0642 | 20.9890 | 10.6248 | Perceived social support and proteintumor estrogen/progesterone receptor status as predictors of natural killer cell activity in breast cancer patients . |
| Perceived social support and tumor estrogen/progesterone receptor status as predictors of proteinnatural killer cell activity in breast cancer patients . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.8887 | 30.2105 | 10.4892 | This report is concerned with the prediction of cell_typenatural killer (NK) cell activity in 61 Stage I and II breast cancer patients , between the ages of 25 and 70, who were accrued to this project. |
| This report is concerned with the prediction of natural cell_typekiller (NK) cell activity in 61 Stage I and II breast cancer patients , between the ages of 25 and 70, who were accrued to this project. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8246 | 10.9271 | 1.0000 | Higher NK activity could be predicted by the perception of high quality emotional support from a spouse or intimate other , perceived social support from the patient's physician , proteinestrogen receptor -negative tumor status , having an excisional biopsy as surgical treatment , and actively seeking social support as a major coping strategy (R2 = 0.33, F(5,55) = 5.5, p less than 0.0004). |
| Higher NK activity could be predicted by the perception of high quality emotional support from a spouse or intimate other , perceived social support from the patient's physician , estrogen receptor -negative tumor status , having an excisional biopsy as proteinsurgical treatment , and actively seeking social support as a major coping strategy (R2 = 0.33, F(5,55) = 5.5, p less than 0.0004). | |||
| Higher NK activity could be predicted by the perception of high quality emotional support from a spouse or intimate other , perceived social support from the patient's physician , estrogen receptor -negative tumor status , having an excisional biopsy as surgical treatment , and actively seeking proteinsocial support as a major coping strategy (R2 = 0.33, F(5,55) = 5.5, p less than 0.0004). | |||
| Higher NK activity could be predicted by the perception of high quality emotional support from a spouse or intimate other , perceived social support from the patient's physician , estrogen receptor -negative tumor status , having an proteinexcisional biopsy as surgical treatment , and actively seeking social support as a major coping strategy (R2 = 0.33, F(5,55) = 5.5, p less than 0.0004). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Findings are discussed in terms of host interaction with proteintumor endocrine status , and the role that social support might play in modulating such activity. | |||
| Findings are discussed in terms of host interaction with tumor endocrine status , and the role that proteinsocial support might play in modulating such activity. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8723 | 10.7748 | 10.3893 | [ Estrogen receptor content of cell_typeperipheral blood lymphocytes in patients with systemic lupus erythematosus ] |
| 1.5458 | 10.7142 | 1.0000 | [ proteinEstrogen receptor content of peripheral blood lymphocytes in patients with systemic lupus erythematosus ] |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7965 | 10.2778 | 1.0000 | ER content in cell_typelymphocytes of peripheral blood from 27 SLE patients and 20 healthy controls were determined by dextran-coated charcoal assay . |
| 0.9859 | 1.0000 | 1.0000 | proteinER content in lymphocytes of peripheral blood from 27 SLE patients and 20 healthy controls were determined by dextran-coated charcoal assay . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6381 | 20.4459 | 10.5316 | ER content in lymphocytes of each sample was expressed by both fmol/mg of proteinlymphocyte cytosolic protein and fmol/micrograms of lymphocyte DNA . |
| 1.6227 | 10.8074 | 1.0000 | ER content in cell_typelymphocytes of each sample was expressed by both fmol/mg of lymphocyte cytosolic protein and fmol/micrograms of lymphocyte DNA . |
| 1.4638 | 10.6539 | 0.9998 | ER content in lymphocytes of each sample was expressed by both fmol/mg of lymphocyte cytosolic protein and fmol/micrograms of DNAlymphocyte DNA . |
| 0.9776 | 1.0000 | 1.0000 | proteinER content in lymphocytes of each sample was expressed by both fmol/mg of lymphocyte cytosolic protein and fmol/micrograms of lymphocyte DNA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6517 | 20.1530 | 1.0000 | The results showed that there was no significant difference between the proteinER content of lymphocytes from the controls and that from patients with SLE . |
| 1.7928 | 10.7726 | 1.0000 | The results showed that there was no significant difference between the ER content of cell_typelymphocytes from the controls and that from patients with SLE . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5857 | 20.5183 | 1.0000 | But the logarithmic mean of ER content in lymphocytes , expressed by fmol/mg of proteincytosolic protein , in 14 patients with active SLE (0.9356 +/- 0.31) was significantly higher than that in 13 patients with inactive SLE (0.2979 +/- 0.23, P less than 0.001) and in the controls (0.6204 +/- 0.52, P less than 0.001). |
| 1.8614 | 10.8579 | 1.0000 | But the logarithmic mean of ER content in cell_typelymphocytes , expressed by fmol/mg of cytosolic protein , in 14 patients with active SLE (0.9356 +/- 0.31) was significantly higher than that in 13 patients with inactive SLE (0.2979 +/- 0.23, P less than 0.001) and in the controls (0.6204 +/- 0.52, P less than 0.001). |
| 1.8390 | 10.7491 | 1.0000 | But the logarithmic mean of proteinER content in lymphocytes , expressed by fmol/mg of cytosolic protein , in 14 patients with active SLE (0.9356 +/- 0.31) was significantly higher than that in 13 patients with inactive SLE (0.2979 +/- 0.23, P less than 0.001) and in the controls (0.6204 +/- 0.52, P less than 0.001). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8383 | 10.1509 | 1.0000 | The normal upper limit of ER content in cell_typelymphocytes , expressed by fmol/micrograms of DNA, was 0.136. |
| 1.7383 | 10.2370 | 1.0000 | The normal upper limit of proteinER content in lymphocytes , expressed by fmol/micrograms of DNA, was 0.136. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8342 | 10.8229 | 1.0000 | The elevated rate of ER content in cell_typelymphocytes in 14 active SLE (92.9%) was also higher than that in quieiescent patients (23.1%, P less than 0.001) and in the controls (10%, P less than 0.001). |
| 1.7835 | 10.7449 | 1.0000 | The elevated rate of proteinER content in lymphocytes in 14 active SLE (92.9%) was also higher than that in quieiescent patients (23.1%, P less than 0.001) and in the controls (10%, P less than 0.001). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3494 | 20.3415 | 0.9999 | Moreover, the elevated level of ER content was found to be related to the positive proteinantidsDNA antibody and hypocomplementemia . |
| 1.6600 | 10.7685 | 1.0000 | Moreover, the elevated level of proteinER content was found to be related to the positive antidsDNA antibody and hypocomplementemia . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7201 | 20.9381 | 10.8972 | An in vitro globin gene switching model based on cell_typedifferentiated embryonic stem cells . |
| 1.9679 | 20.3108 | 0.9998 | An in vitro DNAglobin gene switching model based on differentiated embryonic stem cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.4728 | 20.4648 | 20.2980 | We used cell_typemouse embryonic stem (ES) cells to study globin gene expression and switching in vitro. |
| 1.8747 | 20.3019 | 0.9998 | We used mouse embryonic stem (ES) cells to study DNAglobin gene expression and switching in vitro. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7363 | 30.3907 | 10.9422 | We show that ES-derived embryoid bodies express the full complement of DNAmouse embryonic globin genes in the correct temporal order and that on further differentiation , a switch occurs to the fetal/adult genes . |
| 4.0520 | 20.6946 | 10.8983 | We show that cell_typeES-derived embryoid bodies express the full complement of mouse embryonic globin genes in the correct temporal order and that on further differentiation , a switch occurs to the fetal/adult genes . |
| 2.2336 | 20.5814 | 0.9999 | We show that ES-derived embryoid bodies express the full complement of mouse embryonic globin genes in the correct temporal order and that on further differentiation , a switch occurs to the DNAfetal/adult genes . |
| 0.5447 | 0.9989 | 0.9997 | We show that ES-derived embryoid bodies express the full complement of mouse embryonic DNAglobin genes in the correct temporal order and that on further differentiation , a switch occurs to the fetal/adult genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4089 | 30.0625 | 10.4075 | In addition, the proteinerythroid-specific transcription factor NF-E1 was shown to be expressed coordinately with that of globin in embryoid bodies . |
| 1.4741 | 10.9681 | 1.0000 | In addition, the erythroid-specific transcription factor NF-E1 was shown to be expressed coordinately with that of proteinglobin in embryoid bodies . |
| 0.9735 | 1.0000 | 1.0000 | In addition, the erythroid-specific transcription factor proteinNF-E1 was shown to be expressed coordinately with that of globin in embryoid bodies . |
| In addition, the erythroid-specific transcription factor NF-E1 was shown to be expressed coordinately with that of globin in cell_typeembryoid bodies . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3349 | 20.3637 | 10.2270 | We conclude from these experiments that the cell_lineES cell system provides a good model to study hematopoietic development . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7698 | 30.4188 | 10.3194 | When the human epsilon- or beta- globin genes driven by the DNAdominant control region ( DCR ) are introduced into this system, the human epsilon- globin gene , in contrast to the beta- globin gene , is not deregulated by the presence of the DCR and is expressed strictly as an embryonic gene . |
| 3.0086 | 30.6650 | 20.3970 | When the human epsilon- or beta- globin genes driven by the dominant control region ( DCR ) are introduced into this system, the DNAhuman epsilon- globin gene , in contrast to the beta- globin gene , is not deregulated by the presence of the DCR and is expressed strictly as an embryonic gene . |
| 2.9892 | 30.5356 | 10.5595 | When the human epsilon- or beta- globin genes driven by the dominant control region ( DCR ) are introduced into this system, the human epsilon- globin gene , in contrast to the DNAbeta- globin gene , is not deregulated by the presence of the DCR and is expressed strictly as an embryonic gene . |
| 2.2350 | 20.7607 | 0.9999 | When the human epsilon- or beta- globin genes driven by the dominant control region ( DCR ) are introduced into this system, the human epsilon- globin gene , in contrast to the beta- globin gene , is not deregulated by the presence of the DCR and is expressed strictly as an DNAembryonic gene . |
| 0.9495 | 1.0000 | 1.0000 | When the human epsilon- or beta- globin genes driven by the dominant control region ( DNADCR ) are introduced into this system, the human epsilon- globin gene , in contrast to the beta- globin gene , is not deregulated by the presence of the DCR and is expressed strictly as an embryonic gene . |
| 0.8904 | 1.0000 | 1.0000 | When the human epsilon- or beta- globin genes driven by the dominant control region ( DCR ) are introduced into this system, the human epsilon- globin gene , in contrast to the beta- globin gene , is not deregulated by the presence of the DNADCR and is expressed strictly as an embryonic gene . |
| When the human epsilon- or beta- globin genes driven by the dominant control region ( DCR ) are introduced into this system, the human epsilon- globin gene , in contrast to the beta- DNAglobin gene , is not deregulated by the presence of the DCR and is expressed strictly as an embryonic gene . | |||
| When the human epsilon- or beta- globin genes driven by the dominant control region ( DCR ) are introduced into this system, the human epsilon- DNAglobin gene , in contrast to the beta- globin gene , is not deregulated by the presence of the DCR and is expressed strictly as an embryonic gene . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7911 | 20.6331 | 10.4862 | We conclude from this that the epsilon- globin gene is not regulated by competition with other genes in the DNAhuman beta-globin locus . |
| 3.0531 | 20.5693 | 10.5414 | We conclude from this that the DNAepsilon- globin gene is not regulated by competition with other genes in the human beta-globin locus . |
| We conclude from this that the epsilon- DNAglobin gene is not regulated by competition with other genes in the human beta-globin locus . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4902 | 20.7409 | 10.7761 | Cloning of a mitogen-inducible gene encoding a proteinkappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs . |
| 1.9916 | 20.1966 | 0.9999 | Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the DNArel oncogene and to cell-cycle motifs . |
| 1.9766 | 20.4312 | 0.9996 | Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to DNAcell-cycle motifs . |
| 1.9338 | 20.7365 | 0.9999 | Cloning of a DNAmitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6474 | 20.1377 | 10.7556 | We have cloned and characterized a mitogen-inducible gene isolated from human T cells that predicts a protein of protein968 amino acids . |
| 3.6463 | 20.0318 | 10.9442 | We have cloned and characterized a mitogen-inducible gene isolated from cell_typehuman T cells that predicts a protein of 968 amino acids . |
| 1.4404 | 10.9956 | 0.9999 | We have cloned and characterized a DNAmitogen-inducible gene isolated from human T cells that predicts a protein of 968 amino acids . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2763 | 20.3083 | 1.0000 | The amino-terminal domain has regions homologous to the DNAoncogene rel and to the developmentally important gene dorsal of Drosophila . |
| 1.6264 | 10.8025 | 1.0000 | The proteinamino-terminal domain has regions homologous to the oncogene rel and to the developmentally important gene dorsal of Drosophila . |
| The amino-terminal domain has regions homologous to the oncogene rel and to the developmentally important gene DNAdorsal of Drosophila . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3043 | 20.2728 | 0.9999 | The carboxy-terminal domain contains repeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans , as well as in the putative human oncogene bcl-3 and in the proteinankyrin protein . |
| 1.6464 | 10.5457 | 1.0000 | The proteincarboxy-terminal domain contains repeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans , as well as in the putative human oncogene bcl-3 and in the ankyrin protein . |
| 1.5423 | 10.0218 | 1.0000 | The carboxy-terminal domain contains proteinrepeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans , as well as in the putative human oncogene bcl-3 and in the ankyrin protein . |
| 0.5172 | 0.9996 | 0.9999 | The carboxy-terminal domain contains repeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans , as well as in the putative human DNAoncogene bcl-3 and in the ankyrin protein . |
| The carboxy-terminal domain contains repeat structures found in a variety of proteins that are involved in cell-cycle control of yeast and in tissue differentiation in Drosophila and Ceanorhabditis elegans , as well as in the DNAputative human oncogene bcl-3 and in the ankyrin protein . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0403 | 20.9422 | 10.4917 | A truncated form of the product of this gene translated in vitro is a DNA-binding protein which interacts specifically with the DNAkappa B binding site found in many inducible genes , including the enhancer in human immunodeficiency virus . |
| 2.3004 | 20.4693 | 1.0000 | A truncated form of the product of this gene translated in vitro is a proteinDNA-binding protein which interacts specifically with the kappa B binding site found in many inducible genes , including the enhancer in human immunodeficiency virus . |
| 2.2455 | 20.3328 | 1.0000 | A truncated form of the product of this gene translated in vitro is a DNA-binding protein which interacts specifically with the kappa B binding site found in many DNAinducible genes , including the enhancer in human immunodeficiency virus . |
| 1.7354 | 10.1981 | 1.0000 | A truncated form of the product of this gene translated in vitro is a DNA-binding protein which interacts specifically with the kappa B binding site found in many inducible genes , including the DNAenhancer in human immunodeficiency virus . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5712 | 20.0304 | 1.0000 | This gene is yet another in a growing list of important proteinregulatory molecules whose expression is transcriptionally induced upon cellular activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5235 | 20.0666 | 1.0000 | Extrarenal receptor-effector-mechanisms for aldosterone : the sequence of effects on the cellular electrolyte transport in cell_typehuman lymphocytes and their implications for disorders of the water and electrolyte balances . |
| Extrarenal receptor-effector-mechanisms for aldosterone : the sequence of effects on the cellular electrolyte transport in human cell_typelymphocytes and their implications for disorders of the water and electrolyte balances . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2286 | 20.9218 | 10.7186 | High affinity aldosterone binding sites have not only been described in the classic target tissues such as the renal tubules , but also in non-classic target tissues such as the hippocampus , mammary gland , endothelial cells and, recently, cell_typehuman mononuclear leukocytes . |
| 2.2124 | 20.5581 | 0.9991 | High affinity aldosterone binding sites have not only been described in the classic target tissues such as the renal tubules , but also in non-classic target tissues such as the hippocampus , mammary gland , cell_typeendothelial cells and, recently, human mononuclear leukocytes . |
| 1.7549 | 0.9970 | 10.3334 | proteinHigh affinity aldosterone binding sites have not only been described in the classic target tissues such as the renal tubules , but also in non-classic target tissues such as the hippocampus , mammary gland , endothelial cells and, recently, human mononuclear leukocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8290 | 20.7020 | 10.4964 | An in vitro effect of aldosterone on intracellular sodium , potassium and calcium concentrations and cell volume was shown in cell_typehuman mononuclear leukocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2848 | 20.6630 | 0.9999 | The sodium/proton exchanger of the cell membrane could be identified as the primary target of the aldosterone action, possibly non-genomically mediated through proteinmembrane receptors . |
| 1.6335 | 10.4762 | 1.0000 | The proteinsodium/proton exchanger of the cell membrane could be identified as the primary target of the aldosterone action, possibly non-genomically mediated through membrane receptors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0342 | 20.7088 | 10.4872 | The clinical significance of this model was underlined by the demonstration of absent or a decreased number of mineralocorticoid receptors and the lack of electrolyte response to aldosterone in cell_typehuman mononuclear leukocytes of patients with pseudohypoaldosteronism and aldosteronism . |
| 2.4304 | 20.3921 | 1.0000 | The clinical significance of this model was underlined by the demonstration of absent or a decreased number of proteinmineralocorticoid receptors and the lack of electrolyte response to aldosterone in human mononuclear leukocytes of patients with pseudohypoaldosteronism and aldosteronism . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8183 | 20.2137 | 10.7555 | Additionally, an abnormal effector mechanism could be demonstrated in cell_typehuman mononuclear leukocytes from essential hypertensives . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7386 | 20.5401 | 10.4549 | These studies are the first to demonstrate the significance of proteinextrarenal, nonepithelial mineralocorticoid receptors and the related effector mechanism in different disorders of the water and electrolyte balance in man . |
| 0.7718 | 0.9988 | 0.9999 | These studies are the first to demonstrate the significance of extrarenal, nonepithelial proteinmineralocorticoid receptors and the related effector mechanism in different disorders of the water and electrolyte balance in man . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Immunohistochemical study of steroid hormones and an estrogen binding assay in cell_typemalignant soft tissue tumors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Immunohistochemically, the immunoreaction against 5 steroid hormone anti-sera ( estradiol , estriol , cortisol , progesterone and testosterone ) was examined in 39 cases with the cell_typemalignant soft tissue tumors ( fibrosarcoma : 8, malignant fibrous histiocytoma : 6, rhabdomyosarcoma : 10, leiomyosarcoma : 10, liposarcoma : 5). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6899 | 0.9986 | 10.0991 | Immunostained cell_typetumor cells were more frequently distributed in the area where tumor cell infiltration was more invasive. |
| cell_typeImmunostained tumor cells were more frequently distributed in the area where tumor cell infiltration was more invasive. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6610 | 10.7190 | 1.0000 | Furthermore, the existence of proteinestrogen receptor (estrogen binding activity) was examined histochemically in 39 cases and it was detected in 8. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| We concluded that steroid hormones might be closely related to tumor cell infiltration of some cell_typemalignant soft tissue tumors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3702 | 20.3993 | 10.8856 | Involvement of proteincyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1 . |
| 1.3200 | 10.7008 | 1.0000 | Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for proteininterleukin-1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.0590 | 20.5170 | 20.7501 | Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the DNAhuman immunodeficiency virus long terminal repeat . |
| 3.5507 | 20.5854 | 10.9758 | Expression of a highly specific protein inhibitor for proteincyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat . |
| 3.0220 | 20.9936 | 10.6467 | Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the DNAkappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat . |
| 2.1868 | 20.3177 | 0.9999 | Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in cell_lineinterleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat . |
| 0.8089 | 1.0000 | 0.9979 | Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in proteininterleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat . |
| Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked DNAIL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5602 | 20.6355 | 10.8626 | This inhibitor did not affect protein kinase C -mediated gene transcription , suggesting that proteincyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types . |
| 4.2736 | 20.8514 | 10.9321 | This inhibitor did not affect protein kinase C -mediated gene transcription , suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of cell_typeresponsive cell types . |
| 4.0449 | 20.9608 | 10.8471 | This inhibitor did not affect proteinprotein kinase C -mediated gene transcription , suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types . |
| 1.5421 | 10.3746 | 1.0000 | This inhibitor did not affect protein kinase C -mediated gene transcription , suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for proteinIL-1 in a number of responsive cell types . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5977 | 10.1787 | 0.9508 | The DNAEpstein-Barr virus ( EBV ) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and Z . |
| 4.0267 | 30.6579 | 10.8672 | The Epstein-Barr virus ( EBV ) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV proteintranscription factors R and Z . |
| 1.7659 | 30.5398 | 10.1349 | The Epstein-Barr virus ( EBV ) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the proteinEBV transcription factors R and Z . |
| 0.9229 | 1.0000 | 1.0000 | The Epstein-Barr virus ( EBV ) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors R and proteinZ . |
| 0.7599 | 0.9994 | 1.0000 | The Epstein-Barr virus ( EBV ) ORI1yt enhancer is not B-cell specific and does not respond synergistically to the EBV transcription factors proteinR and Z . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2922 | 20.4208 | 10.9370 | The Epstein-Barr virus DR promoter is located upstream of the PstI repeats , and in addition to the TATA box , it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the proteinBZLF1-encoded transcription factor ) and an enhancer with two functionally distinct domains, A and B . |
| 2.0610 | 20.3362 | 1.0000 | The Epstein-Barr virus DR promoter is located upstream of the DNAPstI repeats , and in addition to the TATA box , it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor ) and an enhancer with two functionally distinct domains, A and B . |
| 1.9933 | 20.2022 | 1.0000 | The Epstein-Barr virus DR promoter is located upstream of the PstI repeats , and in addition to the DNATATA box , it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor ) and an enhancer with two functionally distinct domains, A and B . |
| 1.5381 | 10.4676 | 0.9971 | The DNAEpstein-Barr virus DR promoter is located upstream of the PstI repeats , and in addition to the TATA box , it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor ) and an enhancer with two functionally distinct domains, A and B . |
| 1.5284 | 10.6442 | 1.0000 | The Epstein-Barr virus DR promoter is located upstream of the PstI repeats , and in addition to the TATA box , it contains an upstream region (positions -69 to -220) responsive to proteinEB1 (Z) (the BZLF1-encoded transcription factor ) and an enhancer with two functionally distinct domains, A and B . |
| 1.4109 | 10.3212 | 0.9999 | The Epstein-Barr virus DR promoter is located upstream of the PstI repeats , and in addition to the TATA box , it contains an DNAupstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor ) and an enhancer with two functionally distinct domains, A and B . |
| 0.9327 | 1.0000 | 1.0000 | The Epstein-Barr virus DR promoter is located upstream of the PstI repeats , and in addition to the TATA box , it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor ) and an enhancer with two functionally distinct domains, A and DNAB . |
| 0.9094 | 1.0000 | 1.0000 | The Epstein-Barr virus DR promoter is located upstream of the PstI repeats , and in addition to the TATA box , it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor ) and an enhancer with two functionally distinct domains, DNAA and B . |
| 0.8349 | 1.0000 | 1.0000 | The Epstein-Barr virus DR promoter is located upstream of the PstI repeats , and in addition to the TATA box , it contains an upstream region (positions -69 to -220) responsive to EB1 (Z) (the BZLF1-encoded transcription factor ) and an DNAenhancer with two functionally distinct domains, A and B . |
| 2.3553 | 20.1594 | 0.9993 | The Epstein-Barr virus DR promoter is located upstream of the PstI repeats , and in addition to the TATA box , it contains an upstream region (positions -69 to -220) responsive to proteinEB1 (Z) (the BZLF1-encoded transcription factor ) and an enhancer with two functionally distinct domains, A and B . |
| 0.6371 | 0.9999 | 1.0000 | The Epstein-Barr virus DR promoter is located upstream of the PstI repeats , and in addition to the TATA box , it contains an upstream region (positions -69 to -220) responsive to EB1 protein(Z) (the BZLF1-encoded transcription factor ) and an enhancer with two functionally distinct domains, A and B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3925 | 30.0670 | 10.8975 | Domain B has been described as a B-cell-specific EB1 -responsive element (P.M.Lieberman, J.M.Hardwick, and S.D.Hayward, J.Virol.63:3040-3050, 1989) activated synergistically by EB1 and R , an EBV early product encoded by the DNAopen reading frame BRLF1 (M.A. Cox, J.Leahy, and J.M.Hardwick, J.Virol.64:313-321, 1990). |
| 3.5030 | 20.5771 | 10.1334 | Domain B has been described as a B-cell-specific EB1 -responsive element (P.M.Lieberman, J.M.Hardwick, and S.D.Hayward, J.Virol.63:3040-3050, 1989) activated synergistically by EB1 and R , an proteinEBV early product encoded by the open reading frame BRLF1 (M.A. Cox, J.Leahy, and J.M.Hardwick, J.Virol.64:313-321, 1990). |
| 2.3551 | 30.8872 | 10.3146 | Domain B has been described as a DNAB-cell-specific EB1 -responsive element (P.M.Lieberman, J.M.Hardwick, and S.D.Hayward, J.Virol.63:3040-3050, 1989) activated synergistically by EB1 and R , an EBV early product encoded by the open reading frame BRLF1 (M.A. Cox, J.Leahy, and J.M.Hardwick, J.Virol.64:313-321, 1990). |
| 0.9422 | 1.0000 | 1.0000 | Domain B has been described as a B-cell-specific EB1 -responsive element (P.M.Lieberman, J.M.Hardwick, and S.D.Hayward, J.Virol.63:3040-3050, 1989) activated synergistically by EB1 and proteinR , an EBV early product encoded by the open reading frame BRLF1 (M.A. Cox, J.Leahy, and J.M.Hardwick, J.Virol.64:313-321, 1990). |
| 0.8973 | 1.0000 | 1.0000 | Domain B has been described as a B-cell-specific EB1 -responsive element (P.M.Lieberman, J.M.Hardwick, and S.D.Hayward, J.Virol.63:3040-3050, 1989) activated synergistically by proteinEB1 and R , an EBV early product encoded by the open reading frame BRLF1 (M.A. Cox, J.Leahy, and J.M.Hardwick, J.Virol.64:313-321, 1990). |
| 0.7964 | 0.9999 | 0.9999 | Domain B has been described as a B-cell-specific EB1 -responsive element (P.M.Lieberman, J.M.Hardwick, and S.D.Hayward, J.Virol.63:3040-3050, 1989) activated synergistically by EB1 and R , an EBV early product encoded by the open reading frame DNABRLF1 (M.A. Cox, J.Leahy, and J.M.Hardwick, J.Virol.64:313-321, 1990). |
| 0.7446 | 0.9997 | 1.0000 | DNADomain B has been described as a B-cell-specific EB1 -responsive element (P.M.Lieberman, J.M.Hardwick, and S.D.Hayward, J.Virol.63:3040-3050, 1989) activated synergistically by EB1 and R , an EBV early product encoded by the open reading frame BRLF1 (M.A. Cox, J.Leahy, and J.M.Hardwick, J.Virol.64:313-321, 1990). |
| 0.6374 | 1.0000 | 0.9955 | Domain B has been described as a B-cell-specific proteinEB1 -responsive element (P.M.Lieberman, J.M.Hardwick, and S.D.Hayward, J.Virol.63:3040-3050, 1989) activated synergistically by EB1 and R , an EBV early product encoded by the open reading frame BRLF1 (M.A. Cox, J.Leahy, and J.M.Hardwick, J.Virol.64:313-321, 1990). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2131 | 10.7424 | 10.6792 | We show here that domain B is an R-responsive element in HeLa cells and is therefore not an DNAEB1 -responsive B-cell-specific element . |
| 1.5673 | 10.1538 | 0.9999 | We show here that domain B is an R-responsive element in cell_lineHeLa cells and is therefore not an EB1 -responsive B-cell-specific element . |
| 1.4727 | 10.3592 | 1.0000 | We show here that DNAdomain B is an R-responsive element in HeLa cells and is therefore not an EB1 -responsive B-cell-specific element . |
| 1.3697 | 10.6242 | 1.0000 | We show here that domain B is an DNAR-responsive element in HeLa cells and is therefore not an EB1 -responsive B-cell-specific element . |
| We show here that domain B is an R-responsive element in HeLa cells and is therefore not an proteinEB1 -responsive B-cell-specific element . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5887 | 20.3879 | 10.5004 | However, there is an EB1 -binding site ( ZRE-B ) located within the DNAR-responsive enhancer region . |
| 3.5616 | 20.1462 | 10.8703 | However, there is an DNAEB1 -binding site ( ZRE-B ) located within the R-responsive enhancer region . |
| 0.9320 | 1.0000 | 1.0000 | However, there is an EB1 -binding site ( DNAZRE-B ) located within the R-responsive enhancer region . |
| However, there is an proteinEB1 -binding site ( ZRE-B ) located within the R-responsive enhancer region . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9619 | 1.0000 | 1.0000 | DNAZRE-B can be deleted without affecting the R-dependent enhancer activity . |
| 1.4102 | 10.9915 | 0.9999 | ZRE-B can be deleted without affecting the DNAR-dependent enhancer activity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1776 | 20.4923 | 0.9999 | Moreover, there is no cooperation or synergy between R and EB1 when activating the DNAB domain ( ZRE-B plus the R-responsive element ) positioned as an enhancer . |
| 1.7369 | 10.5276 | 1.0000 | Moreover, there is no cooperation or synergy between R and EB1 when activating the B domain ( DNAZRE-B plus the R-responsive element ) positioned as an enhancer . |
| 1.5124 | 10.4122 | 1.0000 | Moreover, there is no cooperation or synergy between R and EB1 when activating the B domain ( ZRE-B plus the DNAR-responsive element ) positioned as an enhancer . |
| 0.8496 | 0.9999 | 1.0000 | Moreover, there is no cooperation or synergy between proteinR and EB1 when activating the B domain ( ZRE-B plus the R-responsive element ) positioned as an enhancer . |
| 0.8147 | 1.0000 | 1.0000 | Moreover, there is no cooperation or synergy between R and EB1 when activating the B domain ( ZRE-B plus the R-responsive element ) positioned as an DNAenhancer . |
| 0.8705 | 1.0000 | 1.0000 | Moreover, there is no cooperation or synergy between R and DNAEB1 when activating the B domain ( ZRE-B plus the R-responsive element ) positioned as an enhancer . |
| Moreover, there is no cooperation or synergy between R and proteinEB1 when activating the B domain ( ZRE-B plus the R-responsive element ) positioned as an enhancer . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8292 | 20.1258 | 10.6615 | ZRE-B is therefore not part of the DNAR- inducible enhancer . |
| 0.9541 | 1.0000 | 1.0000 | DNAZRE-B is therefore not part of the R- inducible enhancer . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1593 | 30.1449 | 10.6660 | We have tested several subregions of the DR enhancer B domain , either alone or in combination, for their capacity to transmit the R-activating signal to the DNArabbit beta-globin promoter . |
| 3.8949 | 20.8674 | 10.8059 | We have tested several subregions of the DNADR enhancer B domain , either alone or in combination, for their capacity to transmit the R-activating signal to the rabbit beta-globin promoter . |
| We have tested several subregions of the DR enhancer DNAB domain , either alone or in combination, for their capacity to transmit the R-activating signal to the rabbit beta-globin promoter . | |||
| We have tested several subregions of the DNADR enhancer B domain , either alone or in combination, for their capacity to transmit the R-activating signal to the rabbit beta-globin promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2351 | 20.6110 | 1.0000 | We found that the DNAR-responsive element is composed of four protoenhancers that span the whole B domain . |
| 2.1819 | 20.4023 | 0.9999 | We found that the R-responsive element is composed of four protoenhancers that span the whole DNAB domain . |
| 1.6123 | 10.0269 | 1.0000 | We found that the R-responsive element is composed of four DNAprotoenhancers that span the whole B domain . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5550 | 10.4719 | 1.0000 | These protoenhancers alone are weakly or not responsive to proteinR . |
| 0.8577 | 0.9999 | 1.0000 | These DNAprotoenhancers alone are weakly or not responsive to R . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7138 | 10.1108 | 1.0000 | One of the DNAprotoenhancers contains the overlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3' . |
| 0.8877 | 0.9999 | 0.9996 | One of the protoenhancers contains the overlapping DNApalindromes 5'-TTGTCCcgtGGACAAaTGTCC-3' . |
| 0.6992 | 1.0000 | 0.9997 | One of the protoenhancers contains the overlapping palindromes DNA5'-TTGTCCcgtGGACAAaTGTCC-3' . |
| 0.5740 | 0.9998 | 0.9999 | One of the protoenhancers contains the overlapping DNApalindromes 5'-TTGTCCcgtGGACAAaTGTCC-3' . |
| One of the protoenhancers contains the DNAoverlapping palindromes 5'-TTGTCCcgtGGACAAaTGTCC-3' . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7520 | 10.7565 | 1.0000 | However, one DNApalindrome , either alone or duplicated, or the overlapping palindromes did not respond to R. |
| 1.4496 | 10.8910 | 0.9999 | However, one palindrome , either alone or duplicated, or the DNAoverlapping palindromes did not respond to R. |
| 0.9267 | 1.0000 | 1.0000 | However, one palindrome , either alone or duplicated, or the overlapping DNApalindromes did not respond to R. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4407 | 20.5264 | 10.4013 | Nuclear 3,5,3'-triiodothyronine receptors ( T3R ) of cell_typecirculating human lymphocytes in hyper- and hypo thyroidism and nonthyroidal diseases . |
| 0.9662 | 1.0000 | 1.0000 | Nuclear 3,5,3'-triiodothyronine receptors ( proteinT3R ) of circulating human lymphocytes in hyper- and hypo thyroidism and nonthyroidal diseases . |
| 1.6107 | 0.9983 | 10.8193 | proteinNuclear 3,5,3'-triiodothyronine receptors ( T3R ) of circulating human lymphocytes in hyper- and hypo thyroidism and nonthyroidal diseases . |
| Nuclear 3,5,3'-triiodothyronine receptors ( T3R ) of circulating human cell_typelymphocytes in hyper- and hypo thyroidism and nonthyroidal diseases . | |||
| Nuclear protein3,5,3'-triiodothyronine receptors ( T3R ) of circulating human lymphocytes in hyper- and hypo thyroidism and nonthyroidal diseases . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7287 | 10.0761 | 1.0000 | The clinical implications of nuclear proteinT3R alterations of circulating lymphocytes in hyperthyroidism , hypothyroidism and nonthyroidal diseases were investigated. |
| 1.5718 | 10.8230 | 0.9999 | The clinical implications of nuclear T3R alterations of cell_typecirculating lymphocytes in hyperthyroidism , hypothyroidism and nonthyroidal diseases were investigated. |
| The clinical implications of nuclear T3R alterations of circulating cell_typelymphocytes in hyperthyroidism , hypothyroidism and nonthyroidal diseases were investigated. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7462 | 10.1396 | 1.0000 | Nuclear T3R in cell_typelymphocytes was determined by radio-ligand binding analysis . |
| 0.9476 | 1.0000 | 1.0000 | Nuclear proteinT3R in lymphocytes was determined by radio-ligand binding analysis . |
| 0.8773 | 0.9993 | 1.0000 | proteinNuclear T3R in lymphocytes was determined by radio-ligand binding analysis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9146 | 20.8076 | 10.9795 | In hyperthyroidism nuclear proteinT3 maximal binding capacity ( MBC ) was unaltered, whereas in hypothyroidism the MBC was significantly increased. |
| 0.7395 | 1.0000 | 1.0000 | In hyperthyroidism nuclear T3 maximal binding capacity ( proteinMBC ) was unaltered, whereas in hypothyroidism the MBC was significantly increased. |
| 0.5593 | 1.0000 | 1.0000 | In hyperthyroidism nuclear T3 maximal binding capacity ( MBC ) was unaltered, whereas in hypothyroidism the proteinMBC was significantly increased. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8274 | 20.5239 | 0.9970 | In the patients with diabetes mellitus , chronic renal failure and hepatic cirrhosis , the nuclear proteinT3R MBC of lymphocytes was about 1.5-1.6 times of the normal controls . |
| 0.9123 | 0.9999 | 1.0000 | In the patients with diabetes mellitus , chronic renal failure and hepatic cirrhosis , the nuclear T3R MBC of cell_typelymphocytes was about 1.5-1.6 times of the normal controls . |
| 1.7797 | 20.5114 | 1.0000 | In the patients with diabetes mellitus , chronic renal failure and hepatic cirrhosis , the nuclear proteinT3R MBC of lymphocytes was about 1.5-1.6 times of the normal controls . |
| 0.9523 | 1.0000 | 1.0000 | In the patients with diabetes mellitus , chronic renal failure and hepatic cirrhosis , the nuclear T3R proteinMBC of lymphocytes was about 1.5-1.6 times of the normal controls . |
| In the patients with diabetes mellitus , chronic renal failure and hepatic cirrhosis , the proteinnuclear T3R MBC of lymphocytes was about 1.5-1.6 times of the normal controls . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5461 | 20.2886 | 1.0000 | It was concluded that there existed hormonal regulation of proteinnuclear T3R , and up-regulation was seen in hypothyroidism and low T3 syndrome . |
| 0.8581 | 1.0000 | 1.0000 | It was concluded that there existed hormonal regulation of nuclear proteinT3R , and up-regulation was seen in hypothyroidism and low T3 syndrome . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7107 | 20.9126 | 10.9035 | Lymphocyte cell lines from vitamin D-dependent rickets type II show functional defects in the protein1 alpha,25-dihydroxyvitamin D3 receptor . |
| 1.6008 | 0.9979 | 10.6985 | cell_lineLymphocyte cell lines from vitamin D-dependent rickets type II show functional defects in the 1 alpha,25-dihydroxyvitamin D3 receptor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7123 | 0.9985 | 10.9294 | cell_lineLymphocyte cell lines were established from five patients with vitamin D-dependent rickets , type II ( VDDR-II ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9155 | 20.7926 | 10.8132 | Binding of [3H]1 alpha,25-dihydroxyvitamin D3 ( 1,25(OH)2D3 ) to its receptor in these cell lines was compared to binding studies using a cell_lineT-lymphocyte cell line ( S-LB1 ) from a normal individual. |
| 0.9509 | 1.0000 | 1.0000 | Binding of [3H]1 alpha,25-dihydroxyvitamin D3 ( 1,25(OH)2D3 ) to its receptor in these cell lines was compared to binding studies using a T-lymphocyte cell line ( cell_lineS-LB1 ) from a normal individual. |
| 2.3495 | 20.1104 | 0.9999 | Binding of [3H]1 alpha,25-dihydroxyvitamin D3 ( 1,25(OH)2D3 ) to its receptor in these cell_linecell lines was compared to binding studies using a T-lymphocyte cell line ( S-LB1 ) from a normal individual. |
| 0.7854 | 0.9999 | 1.0000 | Binding of [3H]1 alpha,25-dihydroxyvitamin D3 ( 1,25(OH)2D3 ) to its proteinreceptor in these cell lines was compared to binding studies using a T-lymphocyte cell line ( S-LB1 ) from a normal individual. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7754 | 20.8249 | 10.3817 | The 1,25(OH)2D3 receptor of S-LB1 was comparable to the well-characterized proteinchick intestinal 1,25(OH)2D3 receptor in terms of its ligand binding affinity and capacity, its mobility on 5-20% sucrose gradients, and its adsorption to and elution properties from DNA-cellulose . |
| 1.7971 | 10.1837 | 1.0000 | The 1,25(OH)2D3 receptor of cell_lineS-LB1 was comparable to the well-characterized chick intestinal 1,25(OH)2D3 receptor in terms of its ligand binding affinity and capacity, its mobility on 5-20% sucrose gradients, and its adsorption to and elution properties from DNA-cellulose . |
| 1.6591 | 10.6750 | 1.0000 | The protein1,25(OH)2D3 receptor of S-LB1 was comparable to the well-characterized chick intestinal 1,25(OH)2D3 receptor in terms of its ligand binding affinity and capacity, its mobility on 5-20% sucrose gradients, and its adsorption to and elution properties from DNA-cellulose . |
| 0.7729 | 0.9996 | 0.9999 | The 1,25(OH)2D3 receptor of S-LB1 was comparable to the well-characterized chick intestinal protein1,25(OH)2D3 receptor in terms of its ligand binding affinity and capacity, its mobility on 5-20% sucrose gradients, and its adsorption to and elution properties from DNA-cellulose . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4813 | 20.8910 | 1.0000 | Three cell lines established from patients with VDDR-II ( Rh- VDR , Sh- VDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cell_linecultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . |
| 1.6338 | 10.4993 | 0.9999 | Three cell_linecell lines established from patients with VDDR-II ( Rh- VDR , Sh- VDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . |
| 0.5864 | 0.9999 | 1.0000 | Three cell lines established from patients with VDDR-II ( Rh- VDR , Sh- VDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a proteinreceptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . |
| 0.5632 | 1.0000 | 1.0000 | Three cell lines established from patients with VDDR-II ( Rh- proteinVDR , Sh- VDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . |
| 2.4057 | 20.7576 | 0.9999 | Three cell lines established from patients with VDDR-II ( Rh- VDR , Sh- VDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional protein1,25(OH)2D3 receptor . |
| 2.3196 | 20.3042 | 1.0000 | Three cell lines established from patients with VDDR-II ( Rh- VDR , Sh- VDR , and proteinAb- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . |
| 1.7568 | 10.9971 | 1.0000 | Three cell lines established from patients with VDDR-II ( Rh- VDR , proteinSh- VDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . |
| 1.7148 | 10.8402 | 1.0000 | Three cell lines established from patients with VDDR-II ( proteinRh- VDR , Sh- VDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . |
| 1.5285 | 10.9687 | 0.9914 | Three cell lines established from patients with VDDR-II ( Rh- VDR , proteinSh- VDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . |
| 1.4225 | 10.8728 | 0.9876 | Three cell lines established from patients with VDDR-II ( proteinRh- VDR , Sh- VDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . |
| 1.0889 | 20.9562 | 0.9815 | Three cell lines established from patients with VDDR-II ( Rh- VDR , Sh- VDR , and proteinAb- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . |
| Three cell lines established from patients with VDDR-II ( Rh- VDR , Sh- proteinVDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . | |||
| Three cell lines established from patients with VDDR-II ( Rh- VDR , Sh- VDR , and Ab- VDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a proteinfunctional 1,25(OH)2D3 receptor . | |||
| Three cell lines established from patients with VDDR-II ( Rh- VDR , Sh- VDR , and Ab- proteinVDR ) showed no specific binding of 1,25(OH)2D3 to a receptor and treatment of the cultured cells with 1,25(OH)2D3 did not stimulate production of 24,25-dihydroxy-vitamin D3 ( 24,25(OH)2D3 ), a response which is diagnostic of the presence of a functional 1,25(OH)2D3 receptor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5732 | 10.6519 | 0.9999 | In a fourth cell_linecell line , A1-VDR , the receptor for 1,25(OH)2D3 had a low binding capacity and 25(OH)D3-24-hydroxylase activity was not detectable. |
| 0.9399 | 1.0000 | 1.0000 | In a fourth cell line , cell_lineA1-VDR , the receptor for 1,25(OH)2D3 had a low binding capacity and 25(OH)D3-24-hydroxylase activity was not detectable. |
| 0.7807 | 1.0000 | 1.0000 | In a fourth cell line , A1-VDR , the receptor for 1,25(OH)2D3 had a low binding capacity and protein25(OH)D3-24-hydroxylase activity was not detectable. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6874 | 30.2812 | 10.7218 | Induction of 24,25-(OH)2D3 synthesis by 1,25(OH)2D3 was observed in the fifth cell line , designated Ro-VDR , although the sensitivity to hormone treatment was lower than in the cell_linecontrol cell line from a normal donor . |
| 1.4464 | 10.5977 | 1.0000 | Induction of 24,25-(OH)2D3 synthesis by 1,25(OH)2D3 was observed in the fifth cell line , designated cell_lineRo-VDR , although the sensitivity to hormone treatment was lower than in the control cell line from a normal donor . |
| 3.8939 | 20.8749 | 10.9800 | Induction of 24,25-(OH)2D3 synthesis by 1,25(OH)2D3 was observed in the cell_linefifth cell line , designated Ro-VDR , although the sensitivity to hormone treatment was lower than in the control cell line from a normal donor . |
| Induction of 24,25-(OH)2D3 synthesis by 1,25(OH)2D3 was observed in the fifth cell_linecell line , designated Ro-VDR , although the sensitivity to hormone treatment was lower than in the control cell line from a normal donor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6353 | 10.2684 | 1.0000 | The capacity of the receptor for 1,25(OH)2D3 was low in cell_lineRo-VDR . |
| The capacity of the proteinreceptor for 1,25(OH)2D3 was low in Ro-VDR . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4505 | 20.5259 | 1.0000 | In all cell_linecell lines where 1,25(OH)2D3 binding to a receptor was detectable, the receptor had the typical sedimentation coefficient of 3.7 S on sucrose density gradient analysis . |
| 0.8971 | 1.0000 | 1.0000 | In all cell lines where 1,25(OH)2D3 binding to a receptor was detectable, the proteinreceptor had the typical sedimentation coefficient of 3.7 S on sucrose density gradient analysis . |
| 0.8756 | 1.0000 | 1.0000 | In all cell lines where 1,25(OH)2D3 binding to a proteinreceptor was detectable, the receptor had the typical sedimentation coefficient of 3.7 S on sucrose density gradient analysis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3718 | 20.3058 | 1.0000 | Binding and elution properties to DNA-cellulose , however, differed from normal in both Ro-VDR and A1-VDR cells where elution from DNA-cellulose occurred at a lower salt concentration than is typical of the protein1,25(OH)2D3 receptor . |
| 1.5896 | 10.8195 | 0.9999 | Binding and elution properties to DNA-cellulose , however, differed from normal in both Ro-VDR and cell_lineA1-VDR cells where elution from DNA-cellulose occurred at a lower salt concentration than is typical of the 1,25(OH)2D3 receptor . |
| 1.6960 | 10.1872 | 1.0000 | Binding and elution properties to DNA-cellulose , however, differed from normal in both proteinRo-VDR and A1-VDR cells where elution from DNA-cellulose occurred at a lower salt concentration than is typical of the 1,25(OH)2D3 receptor . |
| Binding and elution properties to DNA-cellulose , however, differed from normal in both Ro-VDR and cell_lineA1-VDR cells where elution from DNA-cellulose occurred at a lower salt concentration than is typical of the 1,25(OH)2D3 receptor . | |||
| Binding and elution properties to DNA-cellulose , however, differed from normal in both Ro-VDR and A1-VDR cells where elution from DNA-cellulose occurred at a lower salt concentration than is typical of the 1,25(OH)2D3 proteinreceptor . | |||
| Binding and elution properties to DNA-cellulose , however, differed from normal in both cell_lineRo-VDR and A1-VDR cells where elution from DNA-cellulose occurred at a lower salt concentration than is typical of the 1,25(OH)2D3 receptor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7778 | 20.9432 | 10.8589 | While Ro-VDR cells showed typical nuclear localization of the proteinunoccupied 1,25(OH)2D3 receptor , neither the unoccupied nor the occupied receptor from A1-VDR cells was completely localized in the nucleus . |
| 2.4231 | 20.1327 | 1.0000 | While Ro-VDR cells showed typical nuclear localization of the unoccupied 1,25(OH)2D3 receptor , neither the unoccupied nor the occupied receptor from cell_lineA1-VDR cells was completely localized in the nucleus . |
| 1.6165 | 10.8645 | 0.9999 | While cell_lineRo-VDR cells showed typical nuclear localization of the unoccupied 1,25(OH)2D3 receptor , neither the unoccupied nor the occupied receptor from A1-VDR cells was completely localized in the nucleus . |
| 0.5635 | 1.0000 | 0.9999 | While Ro-VDR cells showed typical nuclear localization of the unoccupied protein1,25(OH)2D3 receptor , neither the unoccupied nor the occupied receptor from A1-VDR cells was completely localized in the nucleus . |
| While Ro-VDR cells showed typical nuclear localization of the unoccupied 1,25(OH)2D3 receptor , neither the unoccupied nor the occupied proteinreceptor from A1-VDR cells was completely localized in the nucleus . | |||
| While Ro-VDR cells showed typical nuclear localization of the unoccupied 1,25(OH)2D3 proteinreceptor , neither the unoccupied nor the occupied receptor from A1-VDR cells was completely localized in the nucleus . | |||
| While Ro-VDR cells showed typical nuclear localization of the unoccupied 1,25(OH)2D3 receptor , neither the unoccupied nor the occupied receptor from cell_lineA1-VDR cells was completely localized in the nucleus . | |||
| While cell_lineRo-VDR cells showed typical nuclear localization of the unoccupied 1,25(OH)2D3 receptor , neither the unoccupied nor the occupied receptor from A1-VDR cells was completely localized in the nucleus . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4700 | 20.0821 | 1.0000 | In a series of functional studies we found that modulation of the level of the mRNAs coding for both the c-myc oncogene and the growth factor known as granulocyte-monocyte colony stimulating activity by 1,25(OH)2D3 correlated with the protein1,25(OH)2D3 receptor status of these cells. |
| 2.3719 | 20.1537 | 1.0000 | In a series of functional studies we found that modulation of the level of the mRNAs coding for both the DNAc-myc oncogene and the growth factor known as granulocyte-monocyte colony stimulating activity by 1,25(OH)2D3 correlated with the 1,25(OH)2D3 receptor status of these cells. |
| 1.8190 | 10.4694 | 1.0000 | In a series of functional studies we found that modulation of the level of the RNAmRNAs coding for both the c-myc oncogene and the growth factor known as granulocyte-monocyte colony stimulating activity by 1,25(OH)2D3 correlated with the 1,25(OH)2D3 receptor status of these cells. |
| 1.6003 | 10.5839 | 0.9999 | In a series of functional studies we found that modulation of the level of the mRNAs coding for both the c-myc oncogene and the proteingrowth factor known as granulocyte-monocyte colony stimulating activity by 1,25(OH)2D3 correlated with the 1,25(OH)2D3 receptor status of these cells. |
| In a series of functional studies we found that modulation of the level of the mRNAs coding for both the c-myc oncogene and the growth factor known as granulocyte-monocyte colony stimulating activity by 1,25(OH)2D3 correlated with the 1,25(OH)2D3 proteinreceptor status of these cells. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5423 | 20.3376 | 0.9999 | Use of these cell_linecell lines will facilitate further study of the molecular defect(s) in the receptor for 1,25(OH)2D3 in vitamin D-dependent rickets type II and will allow a correlation with impairment of cellular functions . |
| Use of these cell lines will facilitate further study of the molecular defect(s) in the proteinreceptor for 1,25(OH)2D3 in vitamin D-dependent rickets type II and will allow a correlation with impairment of cellular functions . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4856 | 10.7858 | 1.0000 | Transcriptional and post-transcriptional regulation of DNAc-jun expression during monocytic differentiation of human myeloid leukemic cells . |
| 3.8686 | 20.7595 | 10.5729 | Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of cell_typehuman myeloid leukemic cells . |
| Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of cell_linehuman myeloid leukemic cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4954 | 20.2741 | 10.8651 | AP-1 , the polypeptide product of c-jun , recognizes and binds to DNAspecific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate ( TPA ). |
| 1.7232 | 10.1645 | 1.0000 | AP-1 , the polypeptide product of DNAc-jun , recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate ( TPA ). |
| 0.9827 | 1.0000 | 1.0000 | proteinAP-1 , the polypeptide product of c-jun , recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate ( TPA ). |
| 0.8924 | 1.0000 | 1.0000 | AP-1 , the polypeptide product of c-jun , recognizes and binds to specific DNA sequences and stimulates transcription of DNAgenes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate ( TPA ). |
| 1.6182 | 10.8834 | 1.0000 | AP-1 , the polypeptide product of c-jun , recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain proteingrowth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate ( TPA ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0013 | 20.1748 | 0.9697 | We studied the effects of TPA on the regulation of DNAc-jun gene expression in HL-60 cells during monocytic differentiation . |
| 1.6220 | 10.9048 | 0.9999 | We studied the effects of TPA on the regulation of c-jun gene expression in cell_lineHL-60 cells during monocytic differentiation . |
| 2.1935 | 20.2897 | 1.0000 | We studied the effects of TPA on the regulation of DNAc-jun gene expression in HL-60 cells during monocytic differentiation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9843 | 20.8176 | 10.6739 | Low levels of c-jun transcripts were detectable in untreated cell_lineHL-60 leukemic cells , increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA . |
| 1.9992 | 20.9663 | 1.0000 | Low levels of proteinc-jun transcripts were detectable in untreated HL-60 leukemic cells , increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA . |
| Low levels of DNAc-jun transcripts were detectable in untreated HL-60 leukemic cells , increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA . | |||
| Low levels of c-jun transcripts were detectable in cell_lineuntreated HL-60 leukemic cells , increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA . | |||
| Low levels of RNAc-jun transcripts were detectable in untreated HL-60 leukemic cells , increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1955 | 10.7075 | 10.9019 | Similar kinetics of c-jun induction by TPA were observed in human U-937 and cell_lineTHP-1 monocytic leukemia cells . |
| 1.4431 | 10.8828 | 0.9996 | Similar kinetics of c-jun induction by TPA were observed in cell_linehuman U-937 and THP-1 monocytic leukemia cells . |
| 1.3537 | 10.9266 | 1.0000 | Similar kinetics of DNAc-jun induction by TPA were observed in human U-937 and THP-1 monocytic leukemia cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9125 | 20.8879 | 10.2467 | Similar findings were obtained with bryostatin 1 (10 nM), another activator of proteinprotein kinase C and inducer of monocytic differentiation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7703 | 10.1731 | 1.0000 | Furthermore, 1,25-dihydroxyvitamin D3 (0.5 microM), a structurally distinct agent which also induces HL-60 monocytic differentiation , increased DNAc-jun expression . |
| 0.9223 | 0.9999 | 1.0000 | Furthermore, 1,25-dihydroxyvitamin D3 (0.5 microM), a structurally distinct agent which also induces cell_lineHL-60 monocytic differentiation , increased c-jun expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2837 | 20.3951 | 0.9999 | TPA treatment of cell_lineHL-60 cells in the presence of cycloheximide was associated with superinduction of c-jun transcripts. |
| 1.8691 | 20.9699 | 0.9995 | TPA treatment of HL-60 cells in the presence of cycloheximide was associated with superinduction of DNAc-jun transcripts. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6337 | 10.7214 | 0.9999 | Run-on analysis demonstrated detectable levels of c-jun gene transcription in untreated cell_lineHL-60 cells , and that exposure to TPA increases this rate 3.3-fold. |
| 2.3857 | 20.4051 | 1.0000 | Run-on analysis demonstrated detectable levels of DNAc-jun gene transcription in untreated HL-60 cells , and that exposure to TPA increases this rate 3.3-fold. |
| Run-on analysis demonstrated detectable levels of DNAc-jun gene transcription in untreated HL-60 cells , and that exposure to TPA increases this rate 3.3-fold. | |||
| Run-on analysis demonstrated detectable levels of c-jun gene transcription in cell_lineuntreated HL-60 cells , and that exposure to TPA increases this rate 3.3-fold. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4182 | 20.1548 | 1.0000 | Treatment of HL-60 cells with both TPA and cycloheximide had no effect on the rates of DNAc-jun transcription . |
| 2.3698 | 20.2267 | 0.9999 | Treatment of cell_lineHL-60 cells with both TPA and cycloheximide had no effect on the rates of c-jun transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5101 | 20.6932 | 1.0000 | The half-life of RNAc-jun RNA as determined by treating HL-60 cells with TPA and actinomycin D was 30 min. |
| 1.5559 | 10.9301 | 0.9999 | The half-life of c-jun RNA as determined by treating cell_lineHL-60 cells with TPA and actinomycin D was 30 min. |
| The half-life of DNAc-jun RNA as determined by treating HL-60 cells with TPA and actinomycin D was 30 min. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0524 | 10.3048 | 10.5226 | In contrast, the half-life of c-jun RNA in cell_lineTPA -treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. |
| 2.4656 | 20.4783 | 0.9999 | In contrast, the half-life of RNAc-jun RNA in TPA -treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. |
| 0.8547 | 0.9984 | 0.9997 | In contrast, the half-life of c-jun RNA in TPA -treated cell_lineHL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. |
| In contrast, the half-life of DNAc-jun RNA in TPA -treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5851 | 20.7357 | 1.0000 | These findings suggested that the increase in RNAc-jun RNA observed during TPA -induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms . |
| These findings suggested that the increase in DNAc-jun RNA observed during TPA -induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5427 | 10.9280 | 1.0000 | [ Hormonal interactions and proteinglucocorticoid receptors in patients with the nephrotic syndrome ] |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5124 | 20.5044 | 1.0000 | It is shown that the low level of steroid receptors , thyroid hormones that the low level of proteinsteroid receptors , thyroid hormones (T3 and T4) and cortisol is typical of children with the signs of renal dysplasia . |
| 2.5054 | 20.6071 | 1.0000 | It is shown that the low level of proteinsteroid receptors , thyroid hormones that the low level of steroid receptors , thyroid hormones (T3 and T4) and cortisol is typical of children with the signs of renal dysplasia . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.6504 | 30.4790 | 20.9096 | Lymphoid specific gene expression of the DNAadenovirus early region 3 promoter is mediated by NF-kappa B binding motifs . |
| 3.5726 | 20.9808 | 10.5224 | Lymphoid specific gene expression of the adenovirus early region 3 promoter is mediated by DNANF-kappa B binding motifs . |
| 1.6218 | 20.8422 | 0.9381 | Lymphoid specific gene expression of the adenovirus early region 3 promoter is mediated by proteinNF-kappa B binding motifs . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4906 | 10.8581 | 0.9997 | A primary site of infection by human adenoviruses is cell_typelymphoid cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5871 | 20.6652 | 10.3996 | However, analysis of the DNAviral control elements and the cellular factors that regulate adenoviral gene expression in lymphocytes has not been reported. |
| 1.6144 | 10.6544 | 1.0000 | However, analysis of the viral control elements and the cellular factors that regulate adenoviral gene expression in cell_typelymphocytes has not been reported. |
| 1.3958 | 10.9636 | 1.0000 | However, analysis of the viral control elements and the proteincellular factors that regulate adenoviral gene expression in lymphocytes has not been reported. |
| 1.4183 | 10.5120 | 0.9999 | However, analysis of the viral control elements and the cellular factors that regulate DNAadenoviral gene expression in lymphocytes has not been reported. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.2868 | 30.7636 | 10.6365 | The adenovirus early region 3 ( ES ) gene products are involved in the maintenance of viral persistence by complexing with the proteinclass I MHC antigens , thus preventing their cell surface expression with a resultant decrease in host immunologic destruction . |
| 3.3734 | 10.7650 | 10.2707 | The proteinadenovirus early region 3 ( ES ) gene products are involved in the maintenance of viral persistence by complexing with the class I MHC antigens , thus preventing their cell surface expression with a resultant decrease in host immunologic destruction . |
| The adenovirus early region 3 ( DNAES ) gene products are involved in the maintenance of viral persistence by complexing with the class I MHC antigens , thus preventing their cell surface expression with a resultant decrease in host immunologic destruction . | |||
| The DNAadenovirus early region 3 ( ES ) gene products are involved in the maintenance of viral persistence by complexing with the class I MHC antigens , thus preventing their cell surface expression with a resultant decrease in host immunologic destruction . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4012 | 20.1006 | 0.9999 | To determine whether different cellular factors were involved in E3 regulation in lymphocytes as compared with cell_lineHeLa cells , both DNA binding and transfection analysis with the E3 promoter in both cell types were performed. |
| 2.2323 | 20.1505 | 1.0000 | To determine whether different proteincellular factors were involved in E3 regulation in lymphocytes as compared with HeLa cells , both DNA binding and transfection analysis with the E3 promoter in both cell types were performed. |
| 2.2029 | 20.3638 | 1.0000 | To determine whether different cellular factors were involved in E3 regulation in lymphocytes as compared with HeLa cells , both DNA binding and transfection analysis with the DNAE3 promoter in both cell types were performed. |
| 1.7173 | 10.3834 | 1.0000 | To determine whether different cellular factors were involved in E3 regulation in cell_typelymphocytes as compared with HeLa cells , both DNA binding and transfection analysis with the E3 promoter in both cell types were performed. |
| 1.9429 | 20.4587 | 0.9902 | To determine whether different cellular factors were involved in E3 regulation in lymphocytes as compared with HeLa cells , both DNA binding and transfection analysis with the proteinE3 promoter in both cell types were performed. |
| 0.8599 | 1.0000 | 1.0000 | To determine whether different cellular factors were involved in proteinE3 regulation in lymphocytes as compared with HeLa cells , both DNA binding and transfection analysis with the E3 promoter in both cell types were performed. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8273 | 10.3876 | 1.0000 | These studies detected two novel domains referred to as DNAL1 and L2 with a variety of lymphoid but not HeLa extracts . |
| 0.9546 | 1.0000 | 1.0000 | These studies detected two novel domains referred to as L1 and DNAL2 with a variety of lymphoid but not HeLa extracts . |
| These studies detected two DNAnovel domains referred to as L1 and L2 with a variety of lymphoid but not HeLa extracts . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9272 | 0.9997 | 0.9999 | Each of these domains possessed strong homology to motifs previously found to bind the cellular factor proteinNF-kappa B . |
| 1.3839 | 10.7423 | 0.9992 | Each of these domains possessed strong homology to motifs previously found to bind the proteincellular factor NF-kappa B . |
| Each of these domains possessed strong homology to motifs previously found to bind the proteincellular factor NF-kappa B . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8934 | 30.1838 | 10.5342 | Transfections of E3 constructs linked to the chloramphenicol acetyltransferase gene revealed that mutagenesis of the DNAdistal NF-kappa B motif ( L2 ) had minimal effects on promoter expression in HeLa cells , but resulted in dramatic decreases in expression by lymphoid cells . |
| 2.3095 | 20.7759 | 0.9999 | Transfections of E3 constructs linked to the DNAchloramphenicol acetyltransferase gene revealed that mutagenesis of the distal NF-kappa B motif ( L2 ) had minimal effects on promoter expression in HeLa cells , but resulted in dramatic decreases in expression by lymphoid cells . |
| 2.2052 | 20.6610 | 0.9999 | Transfections of E3 constructs linked to the chloramphenicol acetyltransferase gene revealed that mutagenesis of the distal NF-kappa B motif ( L2 ) had minimal effects on promoter expression in cell_lineHeLa cells , but resulted in dramatic decreases in expression by lymphoid cells . |
| 2.0507 | 20.9496 | 0.9997 | Transfections of E3 constructs linked to the chloramphenicol acetyltransferase gene revealed that mutagenesis of the distal NF-kappa B motif ( L2 ) had minimal effects on promoter expression in HeLa cells , but resulted in dramatic decreases in expression by cell_typelymphoid cells . |
| 2.0315 | 20.3329 | 1.0000 | Transfections of DNAE3 constructs linked to the chloramphenicol acetyltransferase gene revealed that mutagenesis of the distal NF-kappa B motif ( L2 ) had minimal effects on promoter expression in HeLa cells , but resulted in dramatic decreases in expression by lymphoid cells . |
| 0.9470 | 1.0000 | 1.0000 | Transfections of E3 constructs linked to the chloramphenicol acetyltransferase gene revealed that mutagenesis of the distal NF-kappa B motif ( DNAL2 ) had minimal effects on promoter expression in HeLa cells , but resulted in dramatic decreases in expression by lymphoid cells . |
| 0.7555 | 1.0000 | 0.8949 | Transfections of E3 constructs linked to the chloramphenicol acetyltransferase gene revealed that mutagenesis of the distal proteinNF-kappa B motif ( L2 ) had minimal effects on promoter expression in HeLa cells , but resulted in dramatic decreases in expression by lymphoid cells . |
| 1.4534 | 20.9492 | 0.7368 | Transfections of E3 constructs linked to the proteinchloramphenicol acetyltransferase gene revealed that mutagenesis of the distal NF-kappa B motif ( L2 ) had minimal effects on promoter expression in HeLa cells , but resulted in dramatic decreases in expression by lymphoid cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.9576 | 30.5387 | 10.9010 | In contrast, mutagenesis of DNAproximal NF-kappa B motif ( L1 ) had minimal effects on gene expression in both HeLa cells and lymphoid cells but resulted in a small, but reproducible, increase in gene expression in lymphoid cells when coupled to the L2 mutation . |
| 2.2345 | 20.7527 | 0.9999 | In contrast, mutagenesis of proximal NF-kappa B motif ( L1 ) had minimal effects on gene expression in both HeLa cells and lymphoid cells but resulted in a small, but reproducible, increase in gene expression in cell_typelymphoid cells when coupled to the L2 mutation . |
| 2.2086 | 20.3573 | 0.9999 | In contrast, mutagenesis of proximal NF-kappa B motif ( L1 ) had minimal effects on gene expression in both cell_lineHeLa cells and lymphoid cells but resulted in a small, but reproducible, increase in gene expression in lymphoid cells when coupled to the L2 mutation . |
| 1.6774 | 10.8105 | 0.9999 | In contrast, mutagenesis of proximal NF-kappa B motif ( L1 ) had minimal effects on gene expression in both HeLa cells and lymphoid cells but resulted in a small, but reproducible, increase in gene expression in lymphoid cells when coupled to the DNAL2 mutation . |
| 1.4959 | 10.9932 | 0.9995 | In contrast, mutagenesis of proximal NF-kappa B motif ( L1 ) had minimal effects on gene expression in both HeLa cells and cell_typelymphoid cells but resulted in a small, but reproducible, increase in gene expression in lymphoid cells when coupled to the L2 mutation . |
| 0.9559 | 1.0000 | 1.0000 | In contrast, mutagenesis of proximal NF-kappa B motif ( DNAL1 ) had minimal effects on gene expression in both HeLa cells and lymphoid cells but resulted in a small, but reproducible, increase in gene expression in lymphoid cells when coupled to the L2 mutation . |
| 1.6836 | 30.0081 | 0.8281 | In contrast, mutagenesis of proximal proteinNF-kappa B motif ( L1 ) had minimal effects on gene expression in both HeLa cells and lymphoid cells but resulted in a small, but reproducible, increase in gene expression in lymphoid cells when coupled to the L2 mutation . |
| 0.4626 | 0.9996 | 0.9997 | In contrast, mutagenesis of proximal DNANF-kappa B motif ( L1 ) had minimal effects on gene expression in both HeLa cells and lymphoid cells but resulted in a small, but reproducible, increase in gene expression in lymphoid cells when coupled to the L2 mutation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4776 | 20.3752 | 1.0000 | Reversing the position and subsequent mutagenesis of the L1 and L2 domains indicated that the primary sequence of these motifs rather than their position in the DNAE3 promoter was critical for regulating gene expression . |
| 2.3756 | 20.2712 | 1.0000 | Reversing the position and subsequent mutagenesis of the L1 and L2 domains indicated that the DNAprimary sequence of these motifs rather than their position in the E3 promoter was critical for regulating gene expression . |
| 0.7673 | 1.0000 | 1.0000 | Reversing the position and subsequent mutagenesis of the DNAL1 and L2 domains indicated that the primary sequence of these motifs rather than their position in the E3 promoter was critical for regulating gene expression . |
| 0.5641 | 0.9915 | 0.9999 | Reversing the position and subsequent mutagenesis of the L1 and DNAL2 domains indicated that the primary sequence of these motifs rather than their position in the E3 promoter was critical for regulating gene expression . |
| 0.5616 | 0.9998 | 0.9925 | Reversing the position and subsequent mutagenesis of the L1 and DNAL2 domains indicated that the primary sequence of these motifs rather than their position in the E3 promoter was critical for regulating gene expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5482 | 10.6346 | 1.0000 | Characterization of proteindefensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium . |
| 3.6286 | 20.2889 | 10.3982 | Characterization of defensin resistance phenotypes associated with mutations in the proteinphoP virulence regulon of Salmonella typhimurium . |
| Characterization of defensin resistance phenotypes associated with mutations in the DNAphoP virulence regulon of Salmonella typhimurium . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9490 | 20.3882 | 0.9995 | The defensin sensitivities of Salmonella typhimurium strains with mutations in the phoP/phoQ two-component virulence regulon were tested by using proteinpurified defensins NP-1 and NP-2 . |
| 0.9723 | 1.0000 | 1.0000 | The defensin sensitivities of Salmonella typhimurium strains with mutations in the phoP/phoQ two-component virulence regulon were tested by using purified defensins proteinNP-1 and NP-2 . |
| 0.9548 | 1.0000 | 1.0000 | The defensin sensitivities of Salmonella typhimurium strains with mutations in the phoP/phoQ two-component virulence regulon were tested by using purified defensins NP-1 and proteinNP-2 . |
| 0.8974 | 1.0000 | 1.0000 | The proteindefensin sensitivities of Salmonella typhimurium strains with mutations in the phoP/phoQ two-component virulence regulon were tested by using purified defensins NP-1 and NP-2 . |
| 4.0810 | 20.9410 | 10.9586 | The defensin sensitivities of Salmonella typhimurium strains with mutations in the proteinphoP/phoQ two-component virulence regulon were tested by using purified defensins NP-1 and NP-2 . |
| 0.6229 | 1.0000 | 0.9999 | The defensin sensitivities of Salmonella typhimurium strains with mutations in the phoP/phoQ two-component virulence regulon were tested by using purified proteindefensins NP-1 and NP-2 . |
| The defensin sensitivities of Salmonella typhimurium strains with mutations in the DNAphoP/phoQ two-component virulence regulon were tested by using purified defensins NP-1 and NP-2 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0570 | 10.8875 | 10.6898 | Strains with mutations in either gene of the regulatory pair ( phoP [ transcriptional activator ] or phoQ [ proteinmembrane sensor kinase ]) had increased sensitivities to defensin . |
| 1.6680 | 10.7502 | 1.0000 | Strains with mutations in either gene of the regulatory pair ( phoP [ transcriptional activator ] or DNAphoQ [ membrane sensor kinase ]) had increased sensitivities to defensin . |
| 1.5186 | 10.2322 | 1.0000 | Strains with mutations in either gene of the regulatory pair ( phoP [ transcriptional activator ] or phoQ [ membrane sensor kinase ]) had increased sensitivities to proteindefensin . |
| 0.8928 | 0.9999 | 1.0000 | Strains with mutations in either gene of the regulatory pair ( DNAphoP [ transcriptional activator ] or phoQ [ membrane sensor kinase ]) had increased sensitivities to defensin . |
| 2.1422 | 20.2298 | 0.9999 | Strains with mutations in either gene of the proteinregulatory pair ( phoP [ transcriptional activator ] or phoQ [ membrane sensor kinase ]) had increased sensitivities to defensin . |
| 1.5188 | 10.4233 | 1.0000 | Strains with mutations in either gene of the regulatory pair ( phoP [ proteintranscriptional activator ] or phoQ [ membrane sensor kinase ]) had increased sensitivities to defensin . |
| Strains with mutations in either gene of the DNAregulatory pair ( phoP [ transcriptional activator ] or phoQ [ membrane sensor kinase ]) had increased sensitivities to defensin . | |||
| Strains with mutations in either gene of the regulatory pair ( phoP [ DNAtranscriptional activator ] or phoQ [ membrane sensor kinase ]) had increased sensitivities to defensin . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3115 | 20.2737 | 1.0000 | The predicted proteinperiplasmic domain of the PhoQ protein contained a markedly anionic domain that could interact with cationic proteins and that could be responsible for resistance to defensin . |
| 2.2824 | 20.0903 | 1.0000 | The predicted periplasmic domain of the PhoQ protein contained a markedly anionic domain that could interact with proteincationic proteins and that could be responsible for resistance to defensin . |
| 1.5132 | 10.7316 | 1.0000 | The predicted periplasmic domain of the PhoQ protein contained a markedly anionic domain that could interact with cationic proteins and that could be responsible for resistance to proteindefensin . |
| 1.4757 | 10.6776 | 1.0000 | The predicted periplasmic domain of the proteinPhoQ protein contained a markedly anionic domain that could interact with cationic proteins and that could be responsible for resistance to defensin . |
| 2.2930 | 20.0851 | 1.0000 | The predicted periplasmic domain of the PhoQ protein contained a markedly proteinanionic domain that could interact with cationic proteins and that could be responsible for resistance to defensin . |
| 1.8894 | 20.1537 | 0.9895 | The predicted periplasmic domain of the proteinPhoQ protein contained a markedly anionic domain that could interact with cationic proteins and that could be responsible for resistance to defensin . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1565 | 20.6239 | 10.1403 | Because insertion mutations in phoP are polar on phoQ , we constructed strains that expressed the PhoQ protein in the absence of PhoP to test whether resistance to defensin requires only the proteinphoQ gene product . |
| 2.2845 | 20.8326 | 1.0000 | Because insertion mutations in phoP are polar on phoQ , we constructed strains that expressed the proteinPhoQ protein in the absence of PhoP to test whether resistance to defensin requires only the phoQ gene product . |
| 1.6323 | 10.3327 | 1.0000 | Because insertion mutations in phoP are polar on phoQ , we constructed strains that expressed the PhoQ protein in the absence of proteinPhoP to test whether resistance to defensin requires only the phoQ gene product . |
| 1.3631 | 10.9243 | 1.0000 | Because insertion mutations in DNAphoP are polar on phoQ , we constructed strains that expressed the PhoQ protein in the absence of PhoP to test whether resistance to defensin requires only the phoQ gene product . |
| 1.2707 | 10.8600 | 1.0000 | Because insertion mutations in phoP are polar on DNAphoQ , we constructed strains that expressed the PhoQ protein in the absence of PhoP to test whether resistance to defensin requires only the phoQ gene product . |
| 1.8860 | 20.7841 | 0.9903 | Because insertion mutations in phoP are polar on phoQ , we constructed strains that expressed the proteinPhoQ protein in the absence of PhoP to test whether resistance to defensin requires only the phoQ gene product . |
| 1.6287 | 10.5481 | 1.0000 | Because insertion mutations in phoP are polar on phoQ , we constructed strains that expressed the PhoQ protein in the absence of PhoP to test whether resistance to proteindefensin requires only the phoQ gene product . |
| Because insertion mutations in phoP are polar on phoQ , we constructed strains that expressed the PhoQ protein in the absence of PhoP to test whether resistance to defensin requires only the DNAphoQ gene product . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6955 | 10.5381 | 1.0000 | We found that resistance to defensin requires the function of both components of this regulatory system , because strains expressing PhoQ without PhoP were still markedly sensitive to proteindefensins . |
| 1.6453 | 10.8158 | 1.0000 | We found that resistance to defensin requires the function of both components of this regulatory system , because strains expressing proteinPhoQ without PhoP were still markedly sensitive to defensins . |
| 0.8764 | 1.0000 | 1.0000 | We found that resistance to defensin requires the function of both components of this regulatory system , because strains expressing PhoQ without proteinPhoP were still markedly sensitive to defensins . |
| 1.7480 | 10.6904 | 1.0000 | We found that resistance to proteindefensin requires the function of both components of this regulatory system , because strains expressing PhoQ without PhoP were still markedly sensitive to defensins . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.2847 | 30.5353 | 20.3600 | This implied that a proteinpag ( phoP -activated gene ) product is responsible for defensin resistance . |
| 1.4192 | 10.3296 | 1.0000 | This implied that a pag ( phoP -activated gene ) product is responsible for proteindefensin resistance . |
| 0.7255 | 1.0000 | 0.9946 | This implied that a pag ( proteinphoP -activated gene ) product is responsible for defensin resistance . |
| This implied that a pag ( DNAphoP -activated gene ) product is responsible for defensin resistance . | |||
| This implied that a pag ( DNAphoP -activated gene ) product is responsible for defensin resistance . | |||
| This implied that a DNApag ( phoP -activated gene ) product is responsible for defensin resistance . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4808 | 10.6806 | 1.0000 | We also tested for the ability of proteindefensins NP-1 , NP-5 , and HNP-1 to activate pag expression and found that these peptides have no effect. |
| 0.9801 | 1.0000 | 1.0000 | We also tested for the ability of defensins NP-1 , proteinNP-5 , and HNP-1 to activate pag expression and found that these peptides have no effect. |
| 0.9554 | 1.0000 | 1.0000 | We also tested for the ability of defensins proteinNP-1 , NP-5 , and HNP-1 to activate pag expression and found that these peptides have no effect. |
| 0.9498 | 1.0000 | 1.0000 | We also tested for the ability of defensins NP-1 , NP-5 , and proteinHNP-1 to activate pag expression and found that these peptides have no effect. |
| 1.5842 | 10.4408 | 1.0000 | We also tested for the ability of defensins NP-1 , NP-5 , and HNP-1 to activate proteinpag expression and found that these peptides have no effect. |
| We also tested for the ability of defensins NP-1 , NP-5 , and HNP-1 to activate DNApag expression and found that these peptides have no effect. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3980 | 20.4918 | 1.0000 | Defensin resistance is not the only virulence characteristic controlled by the proteinPhoP -PhoQ regulon because mutations in pagC , as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . |
| 2.3799 | 20.9217 | 1.0000 | Defensin resistance is not the only virulence characteristic controlled by the PhoP -PhoQ regulon because mutations in pagC , as well as ones in the DNAphoP locus that resulted in constitutive pag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . |
| 1.6955 | 10.5622 | 0.9999 | Defensin resistance is not the only virulence characteristic controlled by the PhoP -PhoQ regulon because mutations in pagC , as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within cell_typemacrophages . |
| 0.9158 | 1.0000 | 1.0000 | Defensin resistance is not the only virulence characteristic controlled by the PhoP -PhoQ regulon because mutations in pagC , as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc ), had no effect on proteindefensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . |
| 0.8834 | 1.0000 | 1.0000 | Defensin resistance is not the only virulence characteristic controlled by the PhoP -PhoQ regulon because mutations in pagC , as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype proteinPhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . |
| 1.6989 | 10.5819 | 1.0000 | Defensin resistance is not the only virulence characteristic controlled by the PhoP -PhoQ regulon because mutations in proteinpagC , as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . |
| 0.8768 | 1.0000 | 1.0000 | Defensin resistance is not the only virulence characteristic controlled by the PhoP -PhoQ regulon because mutations in pagC , as well as ones in the phoP locus that resulted in constitutive proteinpag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . |
| 0.4937 | 0.9996 | 0.9999 | Defensin resistance is not the only virulence characteristic controlled by the PhoP protein-PhoQ regulon because mutations in pagC , as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . |
| Defensin resistance is not the only virulence characteristic controlled by the PhoP -PhoQ regulon because mutations in pagC , as well as ones in the phoP locus that resulted in constitutive DNApag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . | |||
| Defensin resistance is not the only virulence characteristic controlled by the PhoP protein-PhoQ regulon because mutations in pagC , as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . | |||
| Defensin resistance is not the only virulence characteristic controlled by the PhoP -PhoQ regulon because mutations in DNApagC , as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . | |||
| Defensin resistance is not the only virulence characteristic controlled by the proteinPhoP -PhoQ regulon because mutations in pagC , as well as ones in the phoP locus that resulted in constitutive pag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . | |||
| Defensin resistance is not the only virulence characteristic controlled by the PhoP -PhoQ regulon because mutations in pagC , as well as ones in the DNAphoP locus that resulted in constitutive pag activation (phenotype PhoPc ), had no effect on defensin resistance , even though they rendered the organism avirulent and deficient in survival within macrophages . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7410 | 10.0696 | 1.0000 | The virulence defect conferred by mutations in the phoP -phoQ two-component regulatory system is not completely explained by alterations in resistance to cationic proteins and involves the control of other proteins necessary for S. typhimurium survival within cell_typemacrophages . |
| 1.5811 | 10.9391 | 1.0000 | The virulence defect conferred by mutations in the phoP -phoQ two-component regulatory system is not completely explained by alterations in resistance to proteincationic proteins and involves the control of other proteins necessary for S. typhimurium survival within macrophages . |
| 1.1744 | 10.1627 | 0.9973 | The virulence defect conferred by mutations in the DNAphoP -phoQ two-component regulatory system is not completely explained by alterations in resistance to cationic proteins and involves the control of other proteins necessary for S. typhimurium survival within macrophages . |
| 4.4758 | 30.2759 | 10.9456 | The virulence defect conferred by mutations in the proteinphoP -phoQ two-component regulatory system is not completely explained by alterations in resistance to cationic proteins and involves the control of other proteins necessary for S. typhimurium survival within macrophages . |
| 1.9572 | 20.1039 | 10.9083 | The virulence defect conferred by mutations in the phoP protein-phoQ two-component regulatory system is not completely explained by alterations in resistance to cationic proteins and involves the control of other proteins necessary for S. typhimurium survival within macrophages . |
| The virulence defect conferred by mutations in the phoP DNA-phoQ two-component regulatory system is not completely explained by alterations in resistance to cationic proteins and involves the control of other proteins necessary for S. typhimurium survival within macrophages . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9637 | 20.9068 | 10.9591 | Stimulation of a cell_linehuman T-cell clone with anti-CD3 or tumor necrosis factor induces NF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription . |
| 2.6303 | 10.4652 | 10.6949 | Stimulation of a human T-cell clone with anti-CD3 or proteintumor necrosis factor induces NF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription . |
| 0.8418 | 0.9997 | 1.0000 | Stimulation of a human T-cell clone with proteinanti-CD3 or tumor necrosis factor induces NF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription . |
| 0.7587 | 0.9986 | 1.0000 | Stimulation of a human T-cell clone with anti-CD3 or tumor necrosis factor induces proteinNF-kappa B translocation but not human immunodeficiency virus 1 enhancer-dependent transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2656 | 20.9265 | 10.8541 | The expression of transiently transfected expression vectors under the control of the long terminal repeat ( LTR ) of the human immunodeficiency virus ( HIV ) or its enhancer sequence and the translocation of the HIV enhancer-binding protein NF-kappa B were analyzed in two human T-cell clones stimulated through their proteinT-cell receptor complex or by tumor necrosis factor or phorbol 12-myristate 13-acetate . |
| 3.6003 | 30.0411 | 10.6231 | The expression of transiently transfected expression vectors under the control of the long terminal repeat ( LTR ) of the human immunodeficiency virus ( HIV ) or its enhancer sequence and the translocation of the HIV enhancer-binding protein NF-kappa B were analyzed in two human T-cell clones stimulated through their T-cell receptor complex or by proteintumor necrosis factor or phorbol 12-myristate 13-acetate . |
| 3.4866 | 20.8560 | 10.5946 | The expression of transiently transfected expression vectors under the control of the long terminal repeat ( LTR ) of the human immunodeficiency virus ( HIV ) or its enhancer sequence and the translocation of the proteinHIV enhancer-binding protein NF-kappa B were analyzed in two human T-cell clones stimulated through their T-cell receptor complex or by tumor necrosis factor or phorbol 12-myristate 13-acetate . |
| 3.4796 | 20.6603 | 10.8350 | The expression of transiently transfected expression vectors under the control of the DNAlong terminal repeat ( LTR ) of the human immunodeficiency virus ( HIV ) or its enhancer sequence and the translocation of the HIV enhancer-binding protein NF-kappa B were analyzed in two human T-cell clones stimulated through their T-cell receptor complex or by tumor necrosis factor or phorbol 12-myristate 13-acetate . |
| 2.1463 | 20.2344 | 0.9999 | The expression of transiently transfected expression vectors under the control of the long terminal repeat ( LTR ) of the human immunodeficiency virus ( HIV ) or its DNAenhancer sequence and the translocation of the HIV enhancer-binding protein NF-kappa B were analyzed in two human T-cell clones stimulated through their T-cell receptor complex or by tumor necrosis factor or phorbol 12-myristate 13-acetate . |
| 0.9560 | 1.0000 | 1.0000 | The expression of transiently transfected expression vectors under the control of the long terminal repeat ( DNALTR ) of the human immunodeficiency virus ( HIV ) or its enhancer sequence and the translocation of the HIV enhancer-binding protein NF-kappa B were analyzed in two human T-cell clones stimulated through their T-cell receptor complex or by tumor necrosis factor or phorbol 12-myristate 13-acetate . |
| 0.9112 | 0.9984 | 1.0000 | The expression of transiently transfected expression vectors under the control of the long terminal repeat ( LTR ) of the human immunodeficiency virus ( HIV ) or its enhancer sequence and the translocation of the HIV enhancer-binding protein proteinNF-kappa B were analyzed in two human T-cell clones stimulated through their T-cell receptor complex or by tumor necrosis factor or phorbol 12-myristate 13-acetate . |
| 3.6788 | 20.7233 | 10.9388 | The expression of transiently transfected expression vectors under the control of the long terminal repeat ( LTR ) of the human immunodeficiency virus ( HIV ) or its enhancer sequence and the translocation of the HIV enhancer-binding protein NF-kappa B were analyzed in two cell_linehuman T-cell clones stimulated through their T-cell receptor complex or by tumor necrosis factor or phorbol 12-myristate 13-acetate . |
| The expression of transiently transfected expression vectors under the control of the long terminal repeat ( LTR ) of the human immunodeficiency virus ( HIV ) or its enhancer sequence and the translocation of the HIV enhancer-binding protein NF-kappa B were analyzed in two human cell_lineT-cell clones stimulated through their T-cell receptor complex or by tumor necrosis factor or phorbol 12-myristate 13-acetate . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5406 | 10.5780 | 1.0000 | We found a dissociation of proteinNF-kappa B translocation from transactivation of either the HIV LTR or the HIV enhancer . |
| 1.5175 | 10.3955 | 0.9999 | We found a dissociation of NF-kappa B translocation from transactivation of either the HIV LTR or the DNAHIV enhancer . |
| 1.5089 | 10.5198 | 1.0000 | We found a dissociation of NF-kappa B translocation from transactivation of either the DNAHIV LTR or the HIV enhancer . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4576 | 10.9262 | 1.0000 | Interleukin 2 induced proliferation but not proteinNF-kappa B translocation or LTR transactivation . |
| 0.9134 | 0.9999 | 1.0000 | proteinInterleukin 2 induced proliferation but not NF-kappa B translocation or LTR transactivation . |
| 0.7925 | 0.9999 | 1.0000 | Interleukin 2 induced proliferation but not NF-kappa B translocation or DNALTR transactivation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6010 | 20.2610 | 10.7275 | Phorbol ester or specific antigen recognition induced HIV LTR transactivation , whereas stimulation with proteintumor necrosis factor or antibody to CD3 did not. |
| 1.4529 | 10.8344 | 0.9999 | Phorbol ester or specific antigen recognition induced DNAHIV LTR transactivation , whereas stimulation with tumor necrosis factor or antibody to CD3 did not. |
| 0.9855 | 1.0000 | 1.0000 | Phorbol ester or specific antigen recognition induced HIV LTR transactivation , whereas stimulation with tumor necrosis factor or antibody to proteinCD3 did not. |
| 1.6419 | 10.7340 | 10.0008 | Phorbol ester or specific antigen recognition induced HIV LTR transactivation , whereas stimulation with tumor necrosis factor or proteinantibody to CD3 did not. |
| 0.7930 | 1.0000 | 1.0000 | Phorbol ester or specific antigen recognition induced HIV DNALTR transactivation , whereas stimulation with tumor necrosis factor or antibody to CD3 did not. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5064 | 20.5050 | 1.0000 | The two latter signals were nevertheless able to induce proteinNF-kappa B translocation with a pattern in the band-shift assay indistinguishable from that observed using phorbol ester . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.0440 | 30.1346 | 10.9725 | Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from cell_typetumoral T cells in terms of requirements for HIV LTR activation . |
| 4.4299 | 20.9954 | 10.8432 | Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer -dependent transcription in cell_linecloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . |
| 3.6567 | 20.8865 | 10.9925 | Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most cell_linelymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . |
| 2.9554 | 10.6378 | 10.5100 | Our finding that induction of NF-kappa B by proteintumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . |
| 2.1653 | 20.1577 | 1.0000 | Our finding that induction of proteinNF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . |
| 2.1283 | 20.2914 | 1.0000 | Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for DNAHIV LTR activation . |
| 1.4357 | 10.9559 | 0.9999 | Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce DNAHIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . |
| 1.2667 | 10.9500 | 0.9999 | Our finding that induction of NF-kappa B by tumor necrosis factor or proteinantibody to CD3 is not sufficient to induce HIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . |
| 4.1995 | 20.9276 | 10.7865 | Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that cell_typenormal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . |
| 0.9709 | 1.0000 | 1.0000 | Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to proteinCD3 is not sufficient to induce HIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . |
| Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal cell_typeT lymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . | |||
| Our finding that induction of NF-kappa B by tumor necrosis factor or antibody to CD3 is not sufficient to induce HIV enhancer -dependent transcription in cloned T cells contrasts with results obtained in most lymphoblastoid T-cell lines and indicates that normal T cell_typelymphocytes differ from tumoral T cells in terms of requirements for HIV LTR activation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0942 | 20.0089 | 0.9126 | Furthermore, our results suggest that events linked to T-cell activation , in addition to NF-kappa B translocation per se, induce functional interactions of the proteinNF-kappa B complex with the HIV enhancer . |
| 1.5254 | 10.4916 | 1.0000 | Furthermore, our results suggest that events linked to T-cell activation , in addition to proteinNF-kappa B translocation per se, induce functional interactions of the NF-kappa B complex with the HIV enhancer . |
| 1.4623 | 10.5361 | 0.9999 | Furthermore, our results suggest that events linked to T-cell activation , in addition to NF-kappa B translocation per se, induce functional interactions of the NF-kappa B complex with the DNAHIV enhancer . |
| 1.4433 | 10.7223 | 0.9999 | Furthermore, our results suggest that events linked to T-cell activation , in addition to NF-kappa B translocation per se, induce functional interactions of the proteinNF-kappa B complex with the HIV enhancer . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6935 | 20.6253 | 10.6039 | Decreased concentration of protein1,25-dihydroxyvitamin D3 receptors in peripheral mononuclear cells of patients with X-linked hypophosphatemic rickets : effect of phosphate supplementation . |
| 3.0769 | 10.9986 | 10.4769 | Decreased concentration of 1,25-dihydroxyvitamin D3 receptors in cell_typeperipheral mononuclear cells of patients with X-linked hypophosphatemic rickets : effect of phosphate supplementation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6903 | 10.5303 | 1.0000 | Since most of the actions of vitamin D are mediated by its receptors ( VDR ), abnormalities of proteinVDR have been postulated in XLH . |
| 0.9437 | 1.0000 | 1.0000 | Since most of the actions of vitamin D are mediated by its receptors ( proteinVDR ), abnormalities of VDR have been postulated in XLH . |
| 1.6460 | 10.3432 | 1.0000 | Since most of the actions of vitamin D are mediated by its proteinreceptors ( VDR ), abnormalities of VDR have been postulated in XLH . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1931 | 20.5250 | 10.6252 | In order to investigate this possibility, we measured the concentration of VDR in cell_linePHA-activated peripheral mononuclear cells from 10 XLH patients . |
| 1.4956 | 10.6842 | 1.0000 | In order to investigate this possibility, we measured the concentration of proteinVDR in PHA-activated peripheral mononuclear cells from 10 XLH patients . |
| In order to investigate this possibility, we measured the concentration of VDR in PHA-activated cell_typeperipheral mononuclear cells from 10 XLH patients . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7488 | 10.4374 | 1.0000 | There was a significant positive correlation between proteinVDR concentration and serum phosphate (P less than 0.05). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7216 | 10.4442 | 1.0000 | In two patients , proteinVDR was increased after daily phosphate supplementation was started. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6971 | 10.8517 | 1.0000 | These results indicate that a decreased concentration of proteinVDR secondary to persistent hypophosphatemia is one of the causes of vitamin D resistance in XLH . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8572 | 20.5429 | 10.9127 | Two distinct forms of active transcription factor CREB ( proteincAMP response element binding protein ). |
| 1.7004 | 20.2061 | 0.9997 | Two distinct forms of active proteintranscription factor CREB ( cAMP response element binding protein ). |
| 0.6909 | 0.9955 | 0.9999 | Two distinct forms of active transcription factor proteinCREB ( cAMP response element binding protein ). |
| Two distinct forms of proteinactive transcription factor CREB ( cAMP response element binding protein ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2032 | 20.5608 | 10.9254 | Mammalian cells express two distinct forms of transcription factor CREB ( proteincAMP response element binding protein ) that are apparently the products of alternative splicing of the CREB gene transcript . |
| 3.5488 | 20.9033 | 10.6467 | Mammalian cells express two distinct forms of proteintranscription factor CREB ( cAMP response element binding protein ) that are apparently the products of alternative splicing of the CREB gene transcript . |
| 3.1599 | 30.1419 | 0.9998 | Mammalian cells express two distinct forms of transcription factor CREB ( cAMP response element binding protein ) that are apparently the products of alternative splicing of the RNACREB gene transcript . |
| 0.8616 | 0.9997 | 0.9997 | cell_typeMammalian cells express two distinct forms of transcription factor CREB ( cAMP response element binding protein ) that are apparently the products of alternative splicing of the CREB gene transcript . |
| 0.7359 | 0.9995 | 1.0000 | Mammalian cells express two distinct forms of transcription factor proteinCREB ( cAMP response element binding protein ) that are apparently the products of alternative splicing of the CREB gene transcript . |
| Mammalian cells express two distinct forms of transcription factor CREB ( cAMP response element binding protein ) that are apparently the products of alternative splicing of the proteinCREB gene transcript . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7710 | 20.4149 | 10.8740 | The two proteins differ by a protein14-amino acid serine-rich insertion present in one of the CREB isoforms . |
| 1.9053 | 20.0970 | 0.9999 | The two proteins differ by a 14-amino acid serine-rich insertion present in one of the proteinCREB isoforms . |
| The two proteins differ by a 14-amino acid serine-rich insertion present in one of the proteinCREB isoforms . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2317 | 20.5161 | 1.0000 | We show that both proteinCREB isoforms are expressed in many cell types and mammalian species . |
| We show that both proteinCREB isoforms are expressed in many cell types and mammalian species . | |||
| We show that both CREB isoforms are expressed in cell_typemany cell types and mammalian species . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7138 | 20.0858 | 10.6864 | Both encode proteins that bind specifically to a DNAcAMP response element in vitro . |
| Both encode proteins that bind specifically to a DNAcAMP response element in vitro . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5307 | 10.8817 | 1.0000 | As expected for proteins of this class, the proteinCREB proteins bind DNA as dimers. |
| As expected for proteins of this class, the proteinCREB proteins bind DNA as dimers. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4108 | 10.9811 | 1.0000 | Both proteins impart cAMP -regulated transcriptional activity to a heterologous DNA-binding domain , showing that cAMP directly modulates the transcriptional stimulatory activity of proteinCREB . |
| 3.7830 | 20.4653 | 10.4686 | Both proteins impart cAMP -regulated transcriptional activity to a proteinheterologous DNA-binding domain , showing that cAMP directly modulates the transcriptional stimulatory activity of CREB . |
| Both proteins impart cAMP -regulated transcriptional activity to a DNAheterologous DNA-binding domain , showing that cAMP directly modulates the transcriptional stimulatory activity of CREB . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9504 | 30.6419 | 0.9860 | The presence of multiple proteinCREB isoforms with identical DNA-binding specificities but differences in the presumed regulatory domain raises the possibility that CREB proteins may be able to integrate distinct regulatory signals at the level of gene transcription . |
| 2.3566 | 20.8673 | 1.0000 | The presence of multiple CREB isoforms with identical DNA-binding specificities but differences in the presumed proteinregulatory domain raises the possibility that CREB proteins may be able to integrate distinct regulatory signals at the level of gene transcription . |
| 2.1972 | 20.9684 | 1.0000 | The presence of multiple proteinCREB isoforms with identical DNA-binding specificities but differences in the presumed regulatory domain raises the possibility that CREB proteins may be able to integrate distinct regulatory signals at the level of gene transcription . |
| 2.1444 | 20.8999 | 1.0000 | The presence of multiple CREB isoforms with identical DNA-binding specificities but differences in the presumed regulatory domain raises the possibility that proteinCREB proteins may be able to integrate distinct regulatory signals at the level of gene transcription . |
| 1.4696 | 20.2525 | 0.9918 | The presence of multiple CREB isoforms with identical DNA-binding specificities but differences in the presumed regulatory domain raises the possibility that proteinCREB proteins may be able to integrate distinct regulatory signals at the level of gene transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3993 | 30.4154 | 10.4269 | Human immunodeficiency virus vpr product is a proteinvirion-associated regulatory protein . |
| 1.6200 | 0.9969 | 10.5551 | proteinHuman immunodeficiency virus vpr product is a virion-associated regulatory protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3328 | 20.8785 | 0.9999 | The vpr product of the human immunodeficiency virus type 1 ( HIV-1 ) acts in trans to accelerate virus replication and cytopathic effect in cell_typeT cells . |
| 1.6922 | 10.7981 | 1.0000 | The proteinvpr product of the human immunodeficiency virus type 1 ( HIV-1 ) acts in trans to accelerate virus replication and cytopathic effect in T cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3056 | 20.5173 | 0.9999 | Here it is shown that the HIV-1 viral particle contains multiple copies of the proteinvpr protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6147 | 10.8430 | 1.0000 | The proteinvpr product is the first regulatory protein of HIV-1 to be found in the virus particle . |
| 2.3421 | 20.3279 | 1.0000 | The vpr product is the first proteinregulatory protein of HIV-1 to be found in the virus particle . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4524 | 20.1666 | 0.9999 | This observation raises the possibility that vpr acts to facilitate the early steps of infection before de novo proteinviral protein synthesis occurs. |
| 1.6851 | 10.8147 | 1.0000 | This observation raises the possibility that proteinvpr acts to facilitate the early steps of infection before de novo viral protein synthesis occurs. |
| This observation raises the possibility that DNAvpr acts to facilitate the early steps of infection before de novo viral protein synthesis occurs. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6838 | 20.9081 | 10.8954 | A novel proteinB-cell lineage-specific transcription factor present at early but not late stages of differentiation . |
| 0.8170 | 0.9934 | 0.9999 | A novel B-cell lineage-specific proteintranscription factor present at early but not late stages of differentiation . |
| A novel B-cell lineage-specific transcription factor present at early but not late stages of proteindifferentiation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3429 | 20.9911 | 10.9224 | A novel proteinB-cell-specific transcription factor , BSAP , was identified as a mammalian homolog of the sea urchin protein TSAP , which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes . |
| 3.5549 | 20.9496 | 10.5705 | A novel B-cell-specific transcription factor , BSAP , was identified as a mammalian homolog of the proteinsea urchin protein TSAP , which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes . |
| 1.7241 | 10.1837 | 1.0000 | A novel B-cell-specific transcription factor , BSAP , was identified as a mammalian homolog of the sea urchin protein TSAP , which interacts with the DNApromoters of four tissue-specific late histone H2A-2 and H2B-2 genes . |
| 0.9592 | 0.9999 | 1.0000 | A novel B-cell-specific transcription factor , BSAP , was identified as a mammalian homolog of the sea urchin protein proteinTSAP , which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes . |
| 0.9527 | 1.0000 | 1.0000 | A novel B-cell-specific transcription factor , proteinBSAP , was identified as a mammalian homolog of the sea urchin protein TSAP , which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes . |
| 0.7063 | 0.9996 | 0.9998 | A novel B-cell-specific proteintranscription factor , BSAP , was identified as a mammalian homolog of the sea urchin protein TSAP , which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes . |
| A novel B-cell-specific transcription factor , BSAP , was identified as a proteinmammalian homolog of the sea urchin protein TSAP , which interacts with the promoters of four tissue-specific late histone H2A-2 and H2B-2 genes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7530 | 20.9130 | 10.8272 | As shown by mobility-shift , methylation interference , and mutational analyses , the mammalian protein BSAP recognizes all four DNAsea urchin binding sites in a manner indistinguishable from TSAP ; however, the two proteins differ in molecular weight. |
| 1.6226 | 10.3552 | 1.0000 | As shown by mobility-shift , methylation interference , and mutational analyses , the mammalian protein BSAP recognizes all four sea urchin binding sites in a manner indistinguishable from proteinTSAP ; however, the two proteins differ in molecular weight. |
| 0.9544 | 1.0000 | 1.0000 | As shown by mobility-shift , methylation interference , and mutational analyses , the mammalian protein proteinBSAP recognizes all four sea urchin binding sites in a manner indistinguishable from TSAP ; however, the two proteins differ in molecular weight. |
| 4.5123 | 30.4194 | 10.7159 | As shown by mobility-shift , methylation interference , and mutational analyses , the proteinmammalian protein BSAP recognizes all four sea urchin binding sites in a manner indistinguishable from TSAP ; however, the two proteins differ in molecular weight. |
| As shown by mobility-shift , methylation interference , and mutational analyses , the proteinmammalian protein BSAP recognizes all four sea urchin binding sites in a manner indistinguishable from TSAP ; however, the two proteins differ in molecular weight. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9779 | 1.0000 | 1.0000 | proteinBSAP is exclusively restricted to the B-cell lineage of lymphoid differentiation . |
| 2.2310 | 20.2629 | 1.0000 | BSAP is exclusively restricted to the cell_typeB-cell lineage of lymphoid differentiation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8259 | 30.1483 | 10.7868 | Its expression appears to be activated during pro-B-cell development , is abundant at the pre-B- and mature B- cell stages , but is absent in cell_typeterminally differentiated plasma cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2453 | 20.2826 | 10.6374 | Moreover, BSAP is clearly a B-cell-specific transcription factor , as a wild-type but not a mutant TSAP -binding site of the sea urchin functions only in cell_linetransfected B cells as an upstream promoter element . |
| 3.9716 | 20.9058 | 10.9053 | Moreover, BSAP is clearly a B-cell-specific transcription factor , as a wild-type but not a mutant TSAP -binding site of the sea urchin functions only in transfected B cells as an DNAupstream promoter element . |
| 3.7190 | 20.4122 | 10.6969 | Moreover, BSAP is clearly a proteinB-cell-specific transcription factor , as a wild-type but not a mutant TSAP -binding site of the sea urchin functions only in transfected B cells as an upstream promoter element . |
| 1.6160 | 10.1722 | 0.9972 | Moreover, BSAP is clearly a B-cell-specific transcription factor , as a wild-type but not a mutant proteinTSAP -binding site of the sea urchin functions only in transfected B cells as an upstream promoter element . |
| 0.8886 | 0.9999 | 1.0000 | Moreover, proteinBSAP is clearly a B-cell-specific transcription factor , as a wild-type but not a mutant TSAP -binding site of the sea urchin functions only in transfected B cells as an upstream promoter element . |
| Moreover, BSAP is clearly a B-cell-specific transcription factor , as a DNAwild-type but not a mutant TSAP -binding site of the sea urchin functions only in transfected B cells as an upstream promoter element . | |||
| Moreover, BSAP is clearly a B-cell-specific transcription factor , as a wild-type but not a DNAmutant TSAP -binding site of the sea urchin functions only in transfected B cells as an upstream promoter element . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3541 | 20.5676 | 10.9850 | Competition experiments did not reveal any DNAhigh-affinity binding site for BSAP in known regulatory regions of immunoglobulin and class II major histocompatibility (MHC) genes , suggesting that BSAP is a regulator of a different set of B-lymphoid-specific genes . |
| 2.0582 | 20.9000 | 0.9999 | Competition experiments did not reveal any high-affinity binding site for BSAP in known regulatory regions of immunoglobulin and class II major histocompatibility (MHC) genes , suggesting that BSAP is a regulator of a different set of DNAB-lymphoid-specific genes . |
| 1.2102 | 10.9355 | 0.9997 | Competition experiments did not reveal any high-affinity binding site for BSAP in known DNAregulatory regions of immunoglobulin and class II major histocompatibility (MHC) genes , suggesting that BSAP is a regulator of a different set of B-lymphoid-specific genes . |
| 0.8451 | 0.9999 | 1.0000 | Competition experiments did not reveal any high-affinity binding site for proteinBSAP in known regulatory regions of immunoglobulin and class II major histocompatibility (MHC) genes , suggesting that BSAP is a regulator of a different set of B-lymphoid-specific genes . |
| 0.8282 | 1.0000 | 1.0000 | Competition experiments did not reveal any high-affinity binding site for BSAP in known regulatory regions of immunoglobulin and class II major histocompatibility (MHC) genes , suggesting that proteinBSAP is a regulator of a different set of B-lymphoid-specific genes . |
| 5.3950 | 20.9153 | 20.9818 | Competition experiments did not reveal any high-affinity binding site for BSAP in known regulatory regions of immunoglobulin and DNAclass II major histocompatibility (MHC) genes , suggesting that BSAP is a regulator of a different set of B-lymphoid-specific genes . |
| 0.6780 | 0.9996 | 0.9997 | Competition experiments did not reveal any high-affinity binding site for BSAP in known regulatory regions of proteinimmunoglobulin and class II major histocompatibility (MHC) genes , suggesting that BSAP is a regulator of a different set of B-lymphoid-specific genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6539 | 0.9994 | 10.6069 | proteinOctamer transcription factors and the cell type-specificity of immunoglobulin gene expression . |
| 2.1516 | 20.1794 | 0.9999 | Octamer transcription factors and the cell type-specificity of DNAimmunoglobulin gene expression . |
| Octamer transcription factors and the DNAcell type-specificity of immunoglobulin gene expression . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.2974 | 10.8038 | 0.9997 | Antibodies are produced exclusively in cell_typeB lymphocytes . |
| 0.9258 | 1.0000 | 1.0000 | proteinAntibodies are produced exclusively in B lymphocytes . |
| Antibodies are produced exclusively in B cell_typelymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8693 | 20.6558 | 10.4993 | The expression of the antibody-encoding genes , the DNAimmunoglobulin (Ig) genes , is also restricted to B cells . |
| 2.0606 | 20.8335 | 0.9999 | The expression of the DNAantibody-encoding genes , the immunoglobulin (Ig) genes , is also restricted to B cells . |
| 1.9886 | 20.5712 | 0.9994 | The expression of the antibody-encoding genes , the immunoglobulin (Ig) genes , is also restricted to cell_typeB cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8106 | 10.0478 | 1.0000 | The octamer sequence ATGCAAAT is present in the promoter and the DNAenhancer of Ig genes , and plays an important role in its tissue-specific expression . |
| 1.6556 | 10.7139 | 1.0000 | The octamer sequence ATGCAAAT is present in the promoter and the enhancer of DNAIg genes , and plays an important role in its tissue-specific expression . |
| 1.5771 | 10.9477 | 0.9999 | The DNAoctamer sequence ATGCAAAT is present in the promoter and the enhancer of Ig genes , and plays an important role in its tissue-specific expression . |
| 0.9429 | 1.0000 | 1.0000 | The octamer sequence ATGCAAAT is present in the DNApromoter and the enhancer of Ig genes , and plays an important role in its tissue-specific expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6996 | 20.1232 | 10.9767 | This sequence motif is a binding site for nuclear proteins , the so-called proteinoctamer transcription factors ( Oct or OTF factors ). |
| 1.4472 | 10.4725 | 1.0000 | This sequence motif is a binding site for proteinnuclear proteins , the so-called octamer transcription factors ( Oct or OTF factors ). |
| 1.3767 | 10.4961 | 0.9998 | This DNAsequence motif is a binding site for nuclear proteins , the so-called octamer transcription factors ( Oct or OTF factors ). |
| 0.9382 | 1.0000 | 1.0000 | This sequence motif is a binding site for nuclear proteins , the so-called octamer transcription factors ( proteinOct or OTF factors ). |
| 0.7453 | 0.9987 | 1.0000 | This sequence motif is a binding site for nuclear proteins , the so-called octamer transcription factors ( Oct or proteinOTF factors ). |
| 1.3896 | 10.9306 | 0.9999 | This sequence motif is a DNAbinding site for nuclear proteins , the so-called octamer transcription factors ( Oct or OTF factors ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1378 | 20.8276 | 0.9999 | The Oct-1 protein is present in all cell types analyzed so far, whereas Oct-2A and Oct-2B are found mainly in cell_typeB lymphocytes . |
| 1.4956 | 10.9105 | 1.0000 | The proteinOct-1 protein is present in all cell types analyzed so far, whereas Oct-2A and Oct-2B are found mainly in B lymphocytes . |
| 0.9587 | 1.0000 | 1.0000 | The Oct-1 protein is present in all cell types analyzed so far, whereas Oct-2A and proteinOct-2B are found mainly in B lymphocytes . |
| 0.9156 | 1.0000 | 1.0000 | The Oct-1 protein is present in all cell types analyzed so far, whereas proteinOct-2A and Oct-2B are found mainly in B lymphocytes . |
| 1.4610 | 10.8377 | 0.9878 | The proteinOct-1 protein is present in all cell types analyzed so far, whereas Oct-2A and Oct-2B are found mainly in B lymphocytes . |
| The Oct-1 protein is present in all cell types analyzed so far, whereas Oct-2A and Oct-2B are found mainly in B cell_typelymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2916 | 10.2597 | 10.2248 | It appears that the B cell-specific expression of Ig genes is mediated at least in part by cell type-specific Oct factors , and that there are both quantitative and qualitative differences between Oct-1 and proteinOct-2 factors . |
| 2.1990 | 20.8345 | 0.9999 | It appears that the B cell-specific expression of DNAIg genes is mediated at least in part by cell type-specific Oct factors , and that there are both quantitative and qualitative differences between Oct-1 and Oct-2 factors . |
| 1.5801 | 10.1516 | 1.0000 | It appears that the B cell-specific expression of Ig genes is mediated at least in part by cell type-specific Oct factors , and that there are both quantitative and qualitative differences between proteinOct-1 and Oct-2 factors . |
| 3.9008 | 30.1660 | 10.5991 | It appears that the B cell-specific expression of Ig genes is mediated at least in part by proteincell type-specific Oct factors , and that there are both quantitative and qualitative differences between Oct-1 and Oct-2 factors . |
| 0.8235 | 0.9990 | 0.9999 | It appears that the B cell-specific expression of Ig genes is mediated at least in part by cell type-specific proteinOct factors , and that there are both quantitative and qualitative differences between Oct-1 and Oct-2 factors . |
| It appears that the B cell-specific expression of Ig genes is mediated at least in part by cell proteintype-specific Oct factors , and that there are both quantitative and qualitative differences between Oct-1 and Oct-2 factors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9915 | 20.0924 | 10.1799 | Recently, a number of other proteinoctamer factor variants were identified. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6834 | 10.6249 | 1.0000 | Many of these may be created by alternative splicing of a RNAprimary transcript of one Oct factor gene and may serve a specific function in the fine tuning of gene expression . |
| 3.1531 | 20.3069 | 10.9732 | Many of these may be created by alternative splicing of a primary transcript of one DNAOct factor gene and may serve a specific function in the fine tuning of gene expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.8969 | 30.2122 | 20.8528 | A factor known to bind to DNAendogenous Ig heavy chain enhancer only in lymphocytes is a ubiquitously active transcription factor . |
| 3.4486 | 20.4178 | 10.7324 | A factor known to bind to endogenous Ig heavy chain enhancer only in lymphocytes is a proteinubiquitously active transcription factor . |
| 1.4143 | 10.0908 | 1.0000 | A factor known to bind to endogenous Ig heavy chain enhancer only in cell_typelymphocytes is a ubiquitously active transcription factor . |
| 0.7200 | 0.9993 | 0.9998 | A factor known to bind to endogenous Ig heavy chain enhancer only in lymphocytes is a ubiquitously active proteintranscription factor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.2615 | 30.9422 | 10.6365 | The transcriptional enhancer located in the first intron of the DNAimmunoglobulin heavy chain constant region is a major determinant of B-cell-specific expression of immunoglobulin genes . |
| 1.8938 | 20.9554 | 0.9997 | The transcriptional enhancer located in the first intron of the immunoglobulin heavy chain constant region is a major determinant of B-cell-specific expression of DNAimmunoglobulin genes . |
| 1.3136 | 10.9559 | 0.9999 | The DNAtranscriptional enhancer located in the first intron of the immunoglobulin heavy chain constant region is a major determinant of B-cell-specific expression of immunoglobulin genes . |
| 1.8018 | 20.3911 | 0.9998 | The transcriptional enhancer located in the DNAfirst intron of the immunoglobulin heavy chain constant region is a major determinant of B-cell-specific expression of immunoglobulin genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4801 | 20.4115 | 10.8149 | Like other enhancers , the DNAIg heavy chain enhancer contains several short sequence motifs that bind specific transcription factors . |
| 1.6135 | 10.7953 | 1.0000 | Like other DNAenhancers , the Ig heavy chain enhancer contains several short sequence motifs that bind specific transcription factors . |
| 3.3614 | 20.3416 | 10.9489 | Like other enhancers , the Ig heavy chain enhancer contains several DNAshort sequence motifs that bind specific transcription factors . |
| 1.8921 | 20.5489 | 0.9998 | Like other enhancers , the Ig heavy chain enhancer contains several short sequence motifs that bind specific proteintranscription factors . |
| Like other enhancers , the Ig heavy chain enhancer contains several short DNAsequence motifs that bind specific transcription factors . | |||
| Like other enhancers , the Ig heavy chain enhancer contains several short sequence motifs that bind proteinspecific transcription factors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7560 | 10.1868 | 1.0000 | Each binding site contributes to the overall activity of the DNAenhancer , however no single element seems absolutely required for activity. |
| 1.6424 | 10.4514 | 0.9999 | Each DNAbinding site contributes to the overall activity of the enhancer , however no single element seems absolutely required for activity. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9598 | 20.5102 | 10.9867 | For a better understanding of the proteinIg heavy chain enhancer components , we have cloned and analyzed individual sequence elements . |
| 3.3024 | 20.9331 | 10.7986 | For a better understanding of the proteinIg heavy chain enhancer components , we have cloned and analyzed individual sequence elements . |
| 1.2042 | 0.9947 | 10.2698 | For a better understanding of the Ig heavy chain proteinenhancer components , we have cloned and analyzed individual sequence elements . |
| For a better understanding of the DNAIg heavy chain enhancer components , we have cloned and analyzed individual sequence elements . | |||
| For a better understanding of the DNAIg heavy chain enhancer components , we have cloned and analyzed individual sequence elements . | |||
| For a better understanding of the Ig heavy chain enhancer components , we have cloned and analyzed individual DNAsequence elements . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5356 | 20.6474 | 10.5561 | We find that the factor that binds to the DNAE3 enhancer motif , CATGTGGC , is a ubiquitous transcription factor . |
| 3.4803 | 20.9780 | 10.7355 | We find that the factor that binds to the E3 enhancer motif , CATGTGGC , is a proteinubiquitous transcription factor . |
| 0.5795 | 0.9996 | 1.0000 | We find that the factor that binds to the E3 enhancer motif , DNACATGTGGC , is a ubiquitous transcription factor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4932 | 10.8256 | 10.2265 | It is present in an active form in both B cells and cell_typenon- B cells , where it can mediate transcriptional activation in vitro and in vivo. |
| 2.3270 | 20.1308 | 0.9998 | It is present in an active form in both cell_typeB cells and non- B cells , where it can mediate transcriptional activation in vitro and in vivo. |
| 0.7947 | 1.0000 | 0.9998 | It is present in an active form in both B cells and non- cell_typeB cells , where it can mediate transcriptional activation in vitro and in vivo. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.3501 | 30.3228 | 20.6447 | However, despite its ability to activate transcription of a transfected reporter gene , the factor is apparently unable to bind to the DNAendogenous Ig heavy chain enhancer in non- lymphoid cells : In previous experiments by others, the characteristic in vivo footprint of this factor, designated NF-muE3 , was detected in B cells but not in non-B cells . |
| 3.2505 | 20.8151 | 10.9413 | However, despite its ability to activate transcription of a DNAtransfected reporter gene , the factor is apparently unable to bind to the endogenous Ig heavy chain enhancer in non- lymphoid cells : In previous experiments by others, the characteristic in vivo footprint of this factor, designated NF-muE3 , was detected in B cells but not in non-B cells . |
| 2.2864 | 20.5546 | 0.9999 | However, despite its ability to activate transcription of a transfected reporter gene , the factor is apparently unable to bind to the endogenous Ig heavy chain enhancer in non- lymphoid cells : In previous experiments by others, the characteristic in vivo footprint of this factor, designated NF-muE3 , was detected in cell_typeB cells but not in non-B cells . |
| 2.2842 | 10.6817 | 10.0723 | However, despite its ability to activate transcription of a transfected reporter gene , the factor is apparently unable to bind to the endogenous Ig heavy chain enhancer in cell_typenon- lymphoid cells : In previous experiments by others, the characteristic in vivo footprint of this factor, designated NF-muE3 , was detected in B cells but not in non-B cells . |
| 2.2787 | 20.2879 | 0.9997 | However, despite its ability to activate transcription of a transfected reporter gene , the factor is apparently unable to bind to the endogenous Ig heavy chain enhancer in non- lymphoid cells : In previous experiments by others, the characteristic in vivo footprint of this factor, designated NF-muE3 , was detected in B cells but not in cell_typenon-B cells . |
| 1.6599 | 10.9835 | 1.0000 | However, despite its ability to activate transcription of a transfected reporter gene , the factor is apparently unable to bind to the endogenous Ig heavy chain enhancer in non- lymphoid cells : In previous experiments by others, the characteristic in vivo footprint of this factor, designated proteinNF-muE3 , was detected in B cells but not in non-B cells . |
| 0.6967 | 1.0000 | 0.9997 | However, despite its ability to activate transcription of a transfected reporter gene , the factor is apparently unable to bind to the endogenous Ig heavy chain enhancer in non- cell_typelymphoid cells : In previous experiments by others, the characteristic in vivo footprint of this factor, designated NF-muE3 , was detected in B cells but not in non-B cells . |
| However, despite its ability to activate transcription of a transfected reporter gene , the factor is apparently unable to bind to the endogenous DNAIg heavy chain enhancer in non- lymphoid cells : In previous experiments by others, the characteristic in vivo footprint of this factor, designated NF-muE3 , was detected in B cells but not in non-B cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8565 | 20.1165 | 10.6865 | From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes : (a) cell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) proteinubiquitously active factors , exemplified by the one binding to the E3 sequence motif . |
| 2.3406 | 20.0056 | 1.0000 | From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes : (a) proteincell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors , exemplified by the one binding to the E3 sequence motif . |
| 2.2496 | 20.8818 | 0.9999 | From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in cell_typeB lymphocytes : (a) cell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors , exemplified by the one binding to the E3 sequence motif . |
| 1.6711 | 10.7108 | 1.0000 | From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes : (a) cell-specific factors such as proteinOct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors , exemplified by the one binding to the E3 sequence motif . |
| 1.6245 | 10.5133 | 1.0000 | From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes : (a) cell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) proteinubiquitous factors such as NF-kappa B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors , exemplified by the one binding to the E3 sequence motif . |
| 1.5895 | 10.9316 | 0.9999 | From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes : (a) cell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa B that are constitutively active in cell_typeB cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors , exemplified by the one binding to the E3 sequence motif . |
| 1.5708 | 10.8743 | 1.0000 | From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes : (a) cell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as proteinNF-kappa B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors , exemplified by the one binding to the E3 sequence motif . |
| 1.4348 | 30.5308 | 0.9998 | From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes : (a) cell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors , exemplified by the one binding to the DNAE3 sequence motif . |
| 0.9528 | 1.0000 | 1.0000 | From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B lymphocytes : (a) cell-specific factors such as Oct-2A and proteinOct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors , exemplified by the one binding to the E3 sequence motif . |
| From this and other findings the picture emerges that there are at least three categories of factors which mediate cell-type-specific transcription in B cell_typelymphocytes : (a) cell-specific factors such as Oct-2A and Oct-2B that are not expressed in most other cell types: (b) ubiquitous factors such as NF-kappa B that are constitutively active in B cells but are sequestered in an inactive form in other cells; (c) ubiquitously active factors , exemplified by the one binding to the E3 sequence motif . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6249 | 20.3245 | 10.9337 | This factor is present in an active form in a variety of cell types but is apparently unable to bind to the DNAendogenous Ig heavy chain enhancer in non-B cells , perhaps due to a non-permissive chromatin structure of the Ig heavy chain locus . |
| 3.7536 | 20.6185 | 10.9642 | This factor is present in an active form in a variety of cell types but is apparently unable to bind to the endogenous Ig heavy chain enhancer in non-B cells , perhaps due to a non-permissive chromatin structure of the DNAIg heavy chain locus . |
| 1.6193 | 10.1414 | 0.9999 | This factor is present in an active form in a variety of cell types but is apparently unable to bind to the endogenous Ig heavy chain enhancer in cell_typenon-B cells , perhaps due to a non-permissive chromatin structure of the Ig heavy chain locus . |
| 3.6341 | 20.2218 | 10.8002 | This factor is present in an active form in a variety of cell types but is apparently unable to bind to the endogenous Ig heavy chain enhancer in non-B cells , perhaps due to a DNAnon-permissive chromatin structure of the Ig heavy chain locus . |
| This factor is present in an active form in a variety of cell types but is apparently unable to bind to the endogenous Ig heavy chain enhancer in non-B cells , perhaps due to a non-permissive DNAchromatin structure of the Ig heavy chain locus . | |||
| This factor is present in an active form in a variety of cell types but is apparently unable to bind to the endogenous DNAIg heavy chain enhancer in non-B cells , perhaps due to a non-permissive chromatin structure of the Ig heavy chain locus . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6001 | 20.3797 | 1.0000 | A study was made of adrenocortical function by measuring blood plasma cortisol concentration and amount of proteinglucocorticoid receptors in lymphocytes as well as thyroid function by measuring blood plasma triidothyronine and thyroxine concentration in 58 bronchial asthma children aged 1 to 14 years. |
| 0.9476 | 1.0000 | 1.0000 | A study was made of adrenocortical function by measuring blood plasma cortisol concentration and amount of glucocorticoid receptors in cell_typelymphocytes as well as thyroid function by measuring blood plasma triidothyronine and thyroxine concentration in 58 bronchial asthma children aged 1 to 14 years. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4654 | 10.8940 | 0.9998 | TAR independent activation of the human immunodeficiency virus in phorbol ester stimulated cell_typeT lymphocytes . |
| 0.9190 | 1.0000 | 1.0000 | DNATAR independent activation of the human immunodeficiency virus in phorbol ester stimulated T lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 8.0061 | 30.9362 | 20.7545 | Multiple regulatory elements in the DNAhuman immunodeficiency virus long terminal repeat ( HIV LTR ) are required for activation of HIV gene expression . |
| 1.4592 | 10.3337 | 0.9999 | Multiple regulatory elements in the human immunodeficiency virus long terminal repeat ( DNAHIV LTR ) are required for activation of HIV gene expression . |
| 1.2529 | 10.9314 | 0.9999 | Multiple DNAregulatory elements in the human immunodeficiency virus long terminal repeat ( HIV LTR ) are required for activation of HIV gene expression . |
| 1.2133 | 10.7667 | 0.9998 | Multiple regulatory elements in the human immunodeficiency virus long terminal repeat ( HIV LTR ) are required for activation of DNAHIV gene expression . |
| Multiple regulatory elements in the human immunodeficiency virus DNAlong terminal repeat ( HIV LTR ) are required for activation of HIV gene expression . | |||
| DNAMultiple regulatory elements in the human immunodeficiency virus long terminal repeat ( HIV LTR ) are required for activation of HIV gene expression . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7492 | 20.4298 | 10.6755 | Previous transfection studies of HIV LTR constructs linked to the DNAchloramphenicol acetyltransferase gene indicated that multiple regulatory regions including the enhancer , SP1 , TATA and TAR regions were important for HIV gene expression . |
| 2.9763 | 20.9761 | 10.5142 | Previous transfection studies of DNAHIV LTR constructs linked to the chloramphenicol acetyltransferase gene indicated that multiple regulatory regions including the enhancer , SP1 , TATA and TAR regions were important for HIV gene expression . |
| 1.6412 | 10.2485 | 1.0000 | Previous transfection studies of HIV LTR constructs linked to the chloramphenicol acetyltransferase gene indicated that multiple regulatory regions including the DNAenhancer , SP1 , TATA and TAR regions were important for HIV gene expression . |
| 0.9051 | 1.0000 | 1.0000 | Previous transfection studies of HIV LTR constructs linked to the chloramphenicol acetyltransferase gene indicated that multiple regulatory regions including the enhancer , DNASP1 , TATA and TAR regions were important for HIV gene expression . |
| 0.6496 | 1.0000 | 1.0000 | Previous transfection studies of HIV LTR constructs linked to the chloramphenicol acetyltransferase gene indicated that multiple regulatory regions including the enhancer , SP1 , DNATATA and TAR regions were important for HIV gene expression . |
| 0.5667 | 0.9994 | 0.9998 | Previous transfection studies of HIV LTR constructs linked to the chloramphenicol acetyltransferase gene indicated that multiple DNAregulatory regions including the enhancer , SP1 , TATA and TAR regions were important for HIV gene expression . |
| 3.3287 | 20.7771 | 10.6952 | Previous transfection studies of HIV LTR constructs linked to the chloramphenicol acetyltransferase gene indicated that DNAmultiple regulatory regions including the enhancer , SP1 , TATA and TAR regions were important for HIV gene expression . |
| 0.5589 | 1.0000 | 0.9993 | Previous transfection studies of HIV LTR constructs linked to the chloramphenicol acetyltransferase gene indicated that multiple regulatory regions including the enhancer , SP1 , TATA and DNATAR regions were important for HIV gene expression . |
| Previous transfection studies of DNAHIV LTR constructs linked to the chloramphenicol acetyltransferase gene indicated that multiple regulatory regions including the enhancer , SP1 , TATA and TAR regions were important for HIV gene expression . | |||
| Previous transfection studies of HIV LTR constructs linked to the chloramphenicol acetyltransferase gene indicated that multiple regulatory regions including the enhancer , SP1 , TATA and DNATAR regions were important for HIV gene expression . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0500 | 20.6490 | 0.9999 | To characterize these DNAregulatory elements further, mutations in these regions were inserted into both the 5' and 3' HIV LTRs and infectious proviral constructs were assembled. |
| 0.8029 | 0.9631 | 0.9984 | To characterize these regulatory elements further, mutations in these regions were inserted into both the 5' and 3' DNAHIV LTRs and infectious proviral constructs were assembled. |
| 4.5885 | 20.7231 | 10.9980 | To characterize these regulatory elements further, mutations in these regions were inserted into both the DNA5' and 3' HIV LTRs and infectious proviral constructs were assembled. |
| 2.1463 | 10.6970 | 10.5984 | To characterize these regulatory elements further, mutations in these regions were inserted into both the 5' and 3' HIV LTRs and DNAinfectious proviral constructs were assembled. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4785 | 20.4134 | 0.9999 | These constructs were transfected into either cell_lineHeLa cells , Jurkat cells or U937 cells in both the presence and absence of phorbol esters which have previously been demonstrated to activate HIV gene expression . |
| 1.7487 | 10.5625 | 0.9999 | These constructs were transfected into either HeLa cells , cell_lineJurkat cells or U937 cells in both the presence and absence of phorbol esters which have previously been demonstrated to activate HIV gene expression . |
| 1.7222 | 10.6673 | 0.9999 | These constructs were transfected into either HeLa cells , Jurkat cells or cell_lineU937 cells in both the presence and absence of phorbol esters which have previously been demonstrated to activate HIV gene expression . |
| 1.4186 | 10.7953 | 0.9998 | These constructs were transfected into either HeLa cells , Jurkat cells or U937 cells in both the presence and absence of phorbol esters which have previously been demonstrated to activate DNAHIV gene expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7190 | 20.9281 | 10.5128 | Viral gene expression was assayed by the level of proteinp24 gag protein released from cultures transfected with the proviral constructs . |
| 2.2009 | 20.4120 | 0.9999 | Viral gene expression was assayed by the level of p24 gag protein released from cultures transfected with the DNAproviral constructs . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9954 | 10.6521 | 10.5982 | Results in all cell lines indicated that mutations of the SP1 , TATA and the TAR loop and stem secondary structure resulted in marked decreases in gene expression while mutations of the enhancer motif or DNATAR primary sequence resulted in only slight decreases. |
| 2.7872 | 10.7281 | 10.7188 | Results in all cell lines indicated that mutations of the SP1 , TATA and the TAR loop and DNAstem secondary structure resulted in marked decreases in gene expression while mutations of the enhancer motif or TAR primary sequence resulted in only slight decreases. |
| 2.0525 | 20.1742 | 0.9998 | Results in all cell lines indicated that mutations of the SP1 , TATA and the TAR loop and stem secondary structure resulted in marked decreases in gene expression while mutations of the DNAenhancer motif or TAR primary sequence resulted in only slight decreases. |
| 1.6331 | 10.0295 | 1.0000 | Results in all cell lines indicated that mutations of the DNASP1 , TATA and the TAR loop and stem secondary structure resulted in marked decreases in gene expression while mutations of the enhancer motif or TAR primary sequence resulted in only slight decreases. |
| 1.3592 | 10.9903 | 0.9999 | Results in all cell lines indicated that mutations of the SP1 , TATA and the DNATAR loop and stem secondary structure resulted in marked decreases in gene expression while mutations of the enhancer motif or TAR primary sequence resulted in only slight decreases. |
| 0.8904 | 1.0000 | 1.0000 | Results in all cell lines indicated that mutations of the SP1 , DNATATA and the TAR loop and stem secondary structure resulted in marked decreases in gene expression while mutations of the enhancer motif or TAR primary sequence resulted in only slight decreases. |
| 2.2587 | 20.6006 | 0.9999 | Results in all cell_linecell lines indicated that mutations of the SP1 , TATA and the TAR loop and stem secondary structure resulted in marked decreases in gene expression while mutations of the enhancer motif or TAR primary sequence resulted in only slight decreases. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.4934 | 30.3211 | 10.9938 | However, viruses containing mutations in either the TAR loop sequences or stem secondary structure which were very defective for gene expression in untreated Jurkat cells , gave nearly wild-type levels of gene expression in phorbol ester -treated Jurkat cells but not in cell_linephorbol ester -treated HeLa or U937 cells . |
| 6.2266 | 30.3511 | 10.4778 | However, viruses containing mutations in either the TAR loop sequences or stem secondary structure which were very defective for gene expression in untreated Jurkat cells , gave nearly wild-type levels of gene expression in cell_linephorbol ester -treated Jurkat cells but not in phorbol ester -treated HeLa or U937 cells . |
| 2.3844 | 20.2810 | 0.9999 | However, viruses containing mutations in either the TAR loop sequences or stem secondary structure which were very defective for gene expression in untreated cell_lineJurkat cells , gave nearly wild-type levels of gene expression in phorbol ester -treated Jurkat cells but not in phorbol ester -treated HeLa or U937 cells . |
| 2.3487 | 20.7289 | 0.9997 | However, viruses containing mutations in either the DNATAR loop sequences or stem secondary structure which were very defective for gene expression in untreated Jurkat cells , gave nearly wild-type levels of gene expression in phorbol ester -treated Jurkat cells but not in phorbol ester -treated HeLa or U937 cells . |
| 2.2644 | 10.4970 | 10.1960 | However, viruses containing mutations in either the TAR loop sequences or DNAstem secondary structure which were very defective for gene expression in untreated Jurkat cells , gave nearly wild-type levels of gene expression in phorbol ester -treated Jurkat cells but not in phorbol ester -treated HeLa or U937 cells . |
| 1.6043 | 10.2264 | 0.9995 | However, viruses containing mutations in either the TAR loop sequences or stem secondary structure which were very defective for gene expression in untreated Jurkat cells , gave nearly wild-type levels of gene expression in phorbol ester -treated Jurkat cells but not in phorbol ester -treated HeLa or cell_lineU937 cells . |
| 0.8454 | 0.9981 | 0.9998 | However, viruses containing mutations in either the TAR loop sequences or stem secondary structure which were very defective for gene expression in untreated Jurkat cells , gave nearly wild-type levels of gene expression in phorbol ester -treated cell_lineJurkat cells but not in phorbol ester -treated HeLa or U937 cells . |
| 0.5737 | 0.9998 | 0.9999 | However, viruses containing mutations in either the TAR loop sequences or stem secondary structure which were very defective for gene expression in untreated Jurkat cells , gave nearly wild-type levels of gene expression in phorbol ester -treated Jurkat cells but not in phorbol ester -treated cell_lineHeLa or U937 cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9769 | 20.4971 | 10.9977 | High level gene expression of these TAR mutant constructs in cell_linephorbol ester -treated Jurkat cells was eliminated by second site mutations in the enhancer region or by disruption of the tat gene . |
| 2.8404 | 30.4043 | 10.1397 | High level gene expression of these DNATAR mutant constructs in phorbol ester -treated Jurkat cells was eliminated by second site mutations in the enhancer region or by disruption of the tat gene . |
| 2.1835 | 20.8546 | 0.9999 | High level gene expression of these TAR mutant constructs in phorbol ester -treated Jurkat cells was eliminated by second site mutations in the DNAenhancer region or by disruption of the tat gene . |
| 2.1746 | 20.8456 | 0.9999 | High level gene expression of these TAR mutant constructs in phorbol ester -treated Jurkat cells was eliminated by second site mutations in the enhancer region or by disruption of the DNAtat gene . |
| 0.8393 | 0.9990 | 0.9998 | High level gene expression of these TAR mutant constructs in phorbol ester -treated cell_lineJurkat cells was eliminated by second site mutations in the enhancer region or by disruption of the tat gene . |
| 1.8527 | 20.7963 | 0.9713 | High level gene expression of these DNATAR mutant constructs in phorbol ester -treated Jurkat cells was eliminated by second site mutations in the enhancer region or by disruption of the tat gene . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6495 | 20.0345 | 10.6092 | A case of hypersensitivity to thyroid hormones with normally functioning thyroid gland and increased proteinnuclear triiodothyronine receptors . |
| A case of hypersensitivity to thyroid hormones with normally functioning thyroid gland and increased nuclear proteintriiodothyronine receptors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8757 | 1.0000 | 1.0000 | The thyroid function was normal regarding T4 , free T4 and T3 , TBG , radioiodine uptake , TSH and T3 suppressibility ; however the proteinTSH response to TRH was decreased. |
| 0.8491 | 1.0000 | 1.0000 | The thyroid function was normal regarding T4 , free T4 and T3 , TBG , radioiodine uptake , proteinTSH and T3 suppressibility ; however the TSH response to TRH was decreased. |
| 0.6378 | 1.0000 | 1.0000 | The thyroid function was normal regarding T4 , free T4 and T3 , proteinTBG , radioiodine uptake , TSH and T3 suppressibility ; however the TSH response to TRH was decreased. |
| 0.5941 | 1.0000 | 1.0000 | The thyroid function was normal regarding T4 , free T4 and proteinT3 , TBG , radioiodine uptake , TSH and T3 suppressibility ; however the TSH response to TRH was decreased. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7524 | 10.5990 | 0.9964 | The proteinlymphocyte nuclear T3 receptor was found with an affinity close to that of normal volunteers (Ka: 1.42 x 10(10) M-1 vs 1.95 +/- 0.35 x 10(10) M-1) and a binding capacity markedly increased (9.9 vs 3.7 +/- 0.4 fmol T3 /100 micrograms DNA). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8720 | 1.0000 | 0.9999 | The clinical course and the laboratory data suggest that the tachycardia crises are the consequence of a hypersensitivity of the heart to thyroid hormones , associated with an increased number of T3 nuclear receptor sites in cell_typelymphocytes . |
| 5.0949 | 30.0452 | 10.7801 | The clinical course and the laboratory data suggest that the tachycardia crises are the consequence of a hypersensitivity of the heart to thyroid hormones , associated with an increased number of proteinT3 nuclear receptor sites in lymphocytes . |
| The clinical course and the laboratory data suggest that the tachycardia crises are the consequence of a hypersensitivity of the heart to thyroid hormones , associated with an increased number of proteinT3 nuclear receptor sites in lymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1173 | 20.1260 | 10.9325 | Induction of DNAimmediate early response genes by macrophage colony-stimulating factor in normal human monocytes . |
| 2.6985 | 10.9985 | 10.5257 | Induction of immediate early response genes by proteinmacrophage colony-stimulating factor in normal human monocytes . |
| 2.6281 | 10.7314 | 10.4283 | Induction of immediate early response genes by macrophage colony-stimulating factor in cell_typenormal human monocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0872 | 20.5027 | 10.9768 | A group of coordinately induced protooncogenes , cytoskeletal , and extracellular matrix genes have been termed DNAimmediate early response genes , and their induction has been associated with growth factor -stimulated cell proliferation . |
| 1.7338 | 10.0214 | 1.0000 | A group of coordinately induced DNAprotooncogenes , cytoskeletal , and extracellular matrix genes have been termed immediate early response genes , and their induction has been associated with growth factor -stimulated cell proliferation . |
| 0.8300 | 0.9991 | 1.0000 | A group of coordinately induced protooncogenes , cytoskeletal , and extracellular matrix genes have been termed immediate early response genes , and their induction has been associated with proteingrowth factor -stimulated cell proliferation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7483 | 10.3996 | 1.0000 | We have investigated the induction of these genes by proteinmacrophage-CSF ( M-CSF ) in human monocytes that do not proliferate in response to M-CSF but require the factor for optimal cell differentiation . |
| 1.7421 | 10.1455 | 1.0000 | We have investigated the induction of these genes by macrophage-CSF ( M-CSF ) in human monocytes that do not proliferate in response to proteinM-CSF but require the factor for optimal cell differentiation . |
| 1.6164 | 10.8554 | 0.9999 | We have investigated the induction of these genes by macrophage-CSF ( M-CSF ) in cell_typehuman monocytes that do not proliferate in response to M-CSF but require the factor for optimal cell differentiation . |
| 0.9886 | 1.0000 | 1.0000 | We have investigated the induction of these genes by macrophage-CSF ( proteinM-CSF ) in human monocytes that do not proliferate in response to M-CSF but require the factor for optimal cell differentiation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8712 | 0.9919 | 0.9999 | Normal cell_typehuman monocytes were isolated, carefully washed, and incubated for 36 to 48 h in fetal bovine serum-containing medium . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3441 | 20.2990 | 1.0000 | At the end of this incubation the cell_typeresting cells were stimulated with M-CSF , and RNA was isolated for analysis by Northern blotting . |
| 1.8226 | 10.8230 | 1.0000 | At the end of this incubation the resting cells were stimulated with M-CSF , and RNARNA was isolated for analysis by Northern blotting . |
| 1.6637 | 10.4440 | 1.0000 | At the end of this incubation the resting cells were stimulated with proteinM-CSF , and RNA was isolated for analysis by Northern blotting . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3414 | 20.0256 | 0.9999 | RNA from control resting cells contained low to undetectable levels of c-jun , fibronectin receptor , and RNAactin mRNA . |
| 2.2283 | 20.1315 | 0.9999 | RNA from control cell_typeresting cells contained low to undetectable levels of c-jun , fibronectin receptor , and actin mRNA . |
| 0.8784 | 0.9997 | 1.0000 | RNARNA from control resting cells contained low to undetectable levels of c-jun , fibronectin receptor , and actin mRNA . |
| 1.4413 | 10.7613 | 1.0000 | RNA from control resting cells contained low to undetectable levels of c-jun , proteinfibronectin receptor , and actin mRNA . |
| 0.7529 | 0.9999 | 1.0000 | RNA from control resting cells contained low to undetectable levels of DNAc-jun , fibronectin receptor , and actin mRNA . |
| RNA from control resting cells contained low to undetectable levels of c-jun , RNAfibronectin receptor , and actin mRNA . | |||
| RNA from control resting cells contained low to undetectable levels of RNAc-jun , fibronectin receptor , and actin mRNA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7262 | 10.9018 | 1.0000 | Within 15 to 30 min of addition of proteinM-CSF , however, there was a dramatic coordinate induction of these genes. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6483 | 10.8963 | 1.0000 | The c-jun gene expression was very transient and was not detectable by 60 min after proteinM-CSF addition . |
| 1.5933 | 10.4841 | 0.9999 | The DNAc-jun gene expression was very transient and was not detectable by 60 min after M-CSF addition . |
| 1.5446 | 10.7099 | 0.9758 | The DNAc-jun gene expression was very transient and was not detectable by 60 min after M-CSF addition . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9099 | 1.0000 | 1.0000 | In contrast, the expression of actin and fibronectin receptor mRNA was more sustained, and the expression of these genes remained elevated at 24 to 48 h after proteinM-CSF addition . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.8940 | 30.6376 | 20.4483 | We also observed the induction of the DNAmyelomonocytic specific tyrosine kinase hck gene simultaneously with the other immediate early response genes . |
| 4.0904 | 20.5906 | 10.8853 | We also observed the induction of the myelomonocytic specific tyrosine kinase hck gene simultaneously with the other DNAimmediate early response genes . |
| We also observed the induction of the proteinmyelomonocytic specific tyrosine kinase hck gene simultaneously with the other immediate early response genes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4713 | 20.2086 | 1.0000 | The protein synthesis inhibitor cycloheximide did not block the induction of any of these genes, and in fact, super-induced the expression of DNAc-jun and hck . |
| 0.8854 | 0.9999 | 1.0000 | The protein synthesis inhibitor cycloheximide did not block the induction of any of these genes, and in fact, super-induced the expression of c-jun and DNAhck . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2716 | 20.0583 | 1.0000 | Nuclear run on transcription of the DNAc-jun , hck , and actin genes . |
| 1.5017 | 10.4917 | 0.9998 | Nuclear run on transcription of the c-jun , hck , and DNAactin genes . |
| 0.8905 | 1.0000 | 1.0000 | Nuclear run on transcription of the c-jun , DNAhck , and actin genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0803 | 20.1305 | 10.8669 | Therefore, in cell_typenormal human monocytes M-CSF induces immediate early response genes without inducing cell proliferation. |
| 3.0640 | 10.5683 | 10.7831 | Therefore, in normal human monocytes M-CSF induces DNAimmediate early response genes without inducing cell proliferation. |
| 0.9355 | 0.9999 | 0.9999 | Therefore, in normal human monocytes proteinM-CSF induces immediate early response genes without inducing cell proliferation. |
| Therefore, in normal cell_typehuman monocytes M-CSF induces immediate early response genes without inducing cell proliferation. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9380 | 1.0000 | 1.0000 | These genes may then play a role in altering the physiologic status of the cells in response to proteinCSF . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5886 | 30.2139 | 10.8101 | Inducible nuclear factor binding to the kappa B elements of the DNAhuman immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner . |
| 3.8004 | 20.5722 | 10.7602 | Inducible nuclear factor binding to the DNAkappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner . |
| 1.5486 | 10.5303 | 0.9998 | Inducible nuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in cell_typeT cells can be blocked by cyclosporin A in a signal-dependent manner . |
| 1.4089 | 0.9980 | 10.9769 | proteinInducible nuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner . |
| Inducible proteinnuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5351 | 20.3857 | 1.0000 | Cyclosporin A ( CsA ) is thought to exert its immunosuppressive effects by inhibiting the expression of a distinct set of DNAlymphokine genes which are induced upon T-cell activation , among them the gene coding for interleukin-2 . |
| 1.7550 | 10.4091 | 1.0000 | Cyclosporin A ( CsA ) is thought to exert its immunosuppressive effects by inhibiting the expression of a distinct set of lymphokine genes which are induced upon T-cell activation , among them the gene coding for proteininterleukin-2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3760 | 20.3827 | 1.0000 | To better understand the molecular mechanisms underlying suppression by CsA , we have investigated the effects of this drug on proteintranscription factors in T cells . |
| 1.6807 | 10.9710 | 0.9998 | To better understand the molecular mechanisms underlying suppression by CsA , we have investigated the effects of this drug on transcription factors in cell_typeT cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6224 | 20.4711 | 10.9084 | Here we report that the formation of two distinct proteinmitogen-inducible DNA-binding complexes , the kappa B complex within the HIV enhancer and the NFAT-1 complex within the interleukin-2 enhancer , is inhibited in the presence of CsA . |
| 3.5829 | 20.1613 | 10.8089 | Here we report that the formation of two distinct mitogen-inducible DNA-binding complexes , the proteinkappa B complex within the HIV enhancer and the NFAT-1 complex within the interleukin-2 enhancer , is inhibited in the presence of CsA . |
| 2.2774 | 20.0319 | 0.9997 | Here we report that the formation of two distinct mitogen-inducible DNA-binding complexes , the kappa B complex within the HIV enhancer and the NFAT-1 complex within the DNAinterleukin-2 enhancer , is inhibited in the presence of CsA . |
| 2.2204 | 20.0906 | 1.0000 | Here we report that the formation of two distinct mitogen-inducible DNA-binding complexes , the kappa B complex within the HIV enhancer and the proteinNFAT-1 complex within the interleukin-2 enhancer , is inhibited in the presence of CsA . |
| 2.1842 | 20.0209 | 1.0000 | Here we report that the formation of two distinct mitogen-inducible DNA-binding complexes , the kappa B complex within the DNAHIV enhancer and the NFAT-1 complex within the interleukin-2 enhancer , is inhibited in the presence of CsA . |
| Here we report that the formation of two distinct mitogen-inducible DNA-binding complexes , the kappa B complex within the HIV enhancer and the NFAT-1 complex within the proteininterleukin-2 enhancer , is inhibited in the presence of CsA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3320 | 20.4023 | 1.0000 | The kappa B-binding activity with the DNAHIV enhancer is inhibited only if it is activated via the mitogen phytohemagglutinin whereas phorbol myristate acetate -mediated activation is completely insensitive to the drug. |
| 0.6516 | 1.0000 | 1.0000 | The kappa B-binding activity with the HIV enhancer is inhibited only if it is activated via the mitogen proteinphytohemagglutinin whereas phorbol myristate acetate -mediated activation is completely insensitive to the drug. |
| 2.4720 | 20.3900 | 1.0000 | The kappa B-binding activity with the HIV enhancer is inhibited only if it is activated via the proteinmitogen phytohemagglutinin whereas phorbol myristate acetate -mediated activation is completely insensitive to the drug. |
| The kappa B-binding activity with the HIV enhancer is inhibited only if it is activated via the proteinmitogen phytohemagglutinin whereas phorbol myristate acetate -mediated activation is completely insensitive to the drug. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7978 | 20.8035 | 10.8040 | This suggests a model in which functionally indistinguishable proteinkappa B complexes can be activated via two separate pathways of signal transduction distinguishable by CsA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.6400 | 40.3900 | 10.8665 | Purification of TCF-1 alpha , a T-cell-specific transcription factor that activates the DNAT-cell receptor C alpha gene enhancer in a context-dependent manner. |
| 2.9558 | 20.6046 | 10.6665 | Purification of TCF-1 alpha , a proteinT-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner. |
| 1.7830 | 20.4589 | 1.0000 | Purification of proteinTCF-1 alpha , a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner. |
| 3.3327 | 40.5271 | 10.7139 | Purification of TCF-1 alpha , a T-cell-specific transcription factor that activates the proteinT-cell receptor C alpha gene enhancer in a context-dependent manner. |
| 1.0401 | 0.9998 | 10.4436 | Purification of TCF-1 alpha , a T-cell-specific proteintranscription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4733 | 20.7436 | 0.9999 | The differentiation of cell_typeT cells into functionally diverse subpopulations is controlled in part, by transcriptional activation and silencing ; however, little is known in detail about the proteins that influence this developmental process . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6593 | 20.6674 | 10.6600 | We have purified a new T-cell-specific factor , TCF-1 alpha , that is implicated in the activation of genes encoding a major component of the proteinhuman T-cell receptor ( TCR ). |
| 2.0224 | 20.5133 | 0.9999 | We have purified a new proteinT-cell-specific factor , TCF-1 alpha , that is implicated in the activation of genes encoding a major component of the human T-cell receptor ( TCR ). |
| 1.6001 | 10.2170 | 1.0000 | We have purified a new T-cell-specific factor , proteinTCF-1 alpha , that is implicated in the activation of genes encoding a major component of the human T-cell receptor ( TCR ). |
| 0.9660 | 1.0000 | 1.0000 | We have purified a new T-cell-specific factor , TCF-1 alpha , that is implicated in the activation of genes encoding a major component of the human T-cell receptor ( proteinTCR ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7466 | 20.7613 | 10.7106 | TCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the DNATCR alpha gene (e.g., p56lck and CD3 delta ). |
| 3.6984 | 20.8326 | 10.6301 | TCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the DNATCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and CD3 delta ). |
| 1.5259 | 10.7507 | 1.0000 | TCF-1 alpha , originally identified and purified through its binding sites on the DNAHIV-1 promoter , was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and CD3 delta ). |
| 0.9385 | 1.0000 | 1.0000 | proteinTCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and CD3 delta ). |
| 0.8785 | 1.0000 | 1.0000 | TCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the TCR alpha enhancer and to DNApromoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and CD3 delta ). |
| 2.2012 | 20.2896 | 0.9999 | TCF-1 alpha , originally identified and purified through its DNAbinding sites on the HIV-1 promoter , was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and CD3 delta ). |
| 0.8995 | 1.0000 | 1.0000 | TCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., proteinp56lck and CD3 delta ). |
| 0.8395 | 10.6766 | 0.9999 | TCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and proteinCD3 delta ). |
| TCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the proteinTCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and CD3 delta ). | |||
| TCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., DNAp56lck and CD3 delta ). | |||
| TCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the TCR alpha enhancer and to promoters for several DNAgenes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and CD3 delta ). | |||
| TCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and DNACD3 delta ). | |||
| TCF-1 alpha , originally identified and purified through its binding sites on the HIV-1 promoter , was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the proteinTCR alpha gene (e.g., p56lck and CD3 delta ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7260 | 30.5243 | 10.6104 | Sequences related to the DNATCF-1 alpha binding motif ( 5'-GGCACCCTTTGA-3' ) are also found in the human TCR delta (and possibly TCR beta ) enhancers . |
| 2.3791 | 30.3303 | 0.9823 | Sequences related to the proteinTCF-1 alpha binding motif ( 5'-GGCACCCTTTGA-3' ) are also found in the human TCR delta (and possibly TCR beta ) enhancers . |
| 3.1732 | 20.9556 | 10.6076 | Sequences related to the TCF-1 alpha binding motif ( 5'-GGCACCCTTTGA-3' ) are also found in the human TCR delta (and possibly DNATCR beta ) enhancers . |
| Sequences related to the TCF-1 alpha binding motif ( 5'-GGCACCCTTTGA-3' ) are also found in the human TCR delta (and possibly DNATCR beta ) enhancers . | |||
| Sequences related to the TCF-1 alpha binding motif ( 5'-GGCACCCTTTGA-3' ) are also found in the DNAhuman TCR delta (and possibly TCR beta ) enhancers . | |||
| Sequences related to the TCF-1 alpha binding motif ( 5'-GGCACCCTTTGA-3' ) are also found in the human TCR delta (and possibly TCR beta ) DNAenhancers . | |||
| Sequences related to the TCF-1 alpha binding motif ( 5'-GGCACCCTTTGA-3' ) are also found in the human proteinTCR delta (and possibly TCR beta ) enhancers . | |||
| Sequences related to the TCF-1 alpha binding motif ( 5'-GGCACCCTTTGA-3' ) are also found in the human TCR delta (and possibly proteinTCR beta ) enhancers . | |||
| Sequences related to the TCF-1 alpha binding motif ( 5'-GGCACCCTTTGA-3' ) are also found in the human DNATCR delta (and possibly TCR beta ) enhancers . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5527 | 30.2227 | 10.4299 | Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of protein57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines ( Jurkat , CCRF-CEM ) and not in mature B cells ( JY , Namalwa ) or nonlymphoid (HeLa) cell lines . |
| 3.8383 | 20.9062 | 10.7468 | Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines ( Jurkat , CCRF-CEM ) and not in mature B cells ( JY , Namalwa ) or cell_linenonlymphoid (HeLa) cell lines . |
| 1.5305 | 10.2454 | 1.0000 | Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that proteinTCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines ( Jurkat , CCRF-CEM ) and not in mature B cells ( JY , Namalwa ) or nonlymphoid (HeLa) cell lines . |
| 0.9467 | 1.0000 | 1.0000 | Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines ( Jurkat , CCRF-CEM ) and not in mature B cells ( cell_lineJY , Namalwa ) or nonlymphoid (HeLa) cell lines . |
| 0.9418 | 1.0000 | 1.0000 | Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines ( Jurkat , cell_lineCCRF-CEM ) and not in mature B cells ( JY , Namalwa ) or nonlymphoid (HeLa) cell lines . |
| 0.9382 | 1.0000 | 1.0000 | Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines ( Jurkat , CCRF-CEM ) and not in mature B cells ( JY , cell_lineNamalwa ) or nonlymphoid (HeLa) cell lines . |
| 0.9227 | 1.0000 | 1.0000 | Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines ( cell_lineJurkat , CCRF-CEM ) and not in mature B cells ( JY , Namalwa ) or nonlymphoid (HeLa) cell lines . |
| 4.1820 | 20.8495 | 10.4860 | Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines ( Jurkat , CCRF-CEM ) and not in cell_typemature B cells ( JY , Namalwa ) or nonlymphoid (HeLa) cell lines . |
| 3.7084 | 20.9562 | 10.3982 | Southwestern and gel renaturation experiments with the use of proteinpurified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines ( Jurkat , CCRF-CEM ) and not in mature B cells ( JY , Namalwa ) or nonlymphoid (HeLa) cell lines . |
| Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines ( Jurkat , CCRF-CEM ) and not in cell_linemature B cells ( JY , Namalwa ) or nonlymphoid (HeLa) cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6671 | 20.8476 | 10.9446 | A small 95-bp fragment of the TCR alpha control region that contains the DNATCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif ) and the binding site for a distinct lymphoid-specific protein ( TCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. |
| 4.3478 | 20.9826 | 10.5387 | A small 95-bp fragment of the DNATCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif ) and the binding site for a distinct lymphoid-specific protein ( TCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. |
| 3.8198 | 20.0609 | 10.8387 | A small 95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or DNAT alpha 1 motif ) and the binding site for a distinct lymphoid-specific protein ( TCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. |
| 1.9941 | 20.8335 | 0.9999 | A small 95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif ) and the binding site for a distinct lymphoid-specific protein ( TCF-2 alpha ) behaved as a potent DNAT-cell-specific enhancer in vivo. |
| 1.9269 | 20.1585 | 0.9999 | A small 95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a DNAcAMP-response element (the CRE or T alpha 1 motif ) and the binding site for a distinct lymphoid-specific protein ( TCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. |
| 1.8949 | 20.7261 | 0.9419 | A small 95-bp fragment of the TCR alpha control region that contains the proteinTCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif ) and the binding site for a distinct lymphoid-specific protein ( TCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. |
| 1.4510 | 10.6238 | 1.0000 | A small 95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif ) and the binding site for a distinct proteinlymphoid-specific protein ( TCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. |
| 1.2491 | 10.2741 | 0.9997 | A small 95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif ) and the DNAbinding site for a distinct lymphoid-specific protein ( TCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. |
| 0.8668 | 1.0000 | 1.0000 | A small 95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the DNACRE or T alpha 1 motif ) and the binding site for a distinct lymphoid-specific protein ( TCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. |
| 0.8167 | 0.9998 | 1.0000 | A small 95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif ) and the binding site for a distinct lymphoid-specific protein ( proteinTCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. |
| 2.0664 | 20.7225 | 0.9999 | A small DNA95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif ) and the binding site for a distinct lymphoid-specific protein ( TCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. |
| A small 95-bp fragment of the proteinTCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif ) and the binding site for a distinct lymphoid-specific protein ( TCF-2 alpha ) behaved as a potent T-cell-specific enhancer in vivo. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1110 | 10.9080 | 10.8387 | Tandem copies of this enhancer functioned synergistically in cell_linemature (Jurkat) T-cell lines as well as resting and activated immature (CCRF-CEM) T-cell lines . |
| 2.8507 | 10.9349 | 10.9051 | Tandem copies of this enhancer functioned synergistically in mature (Jurkat) T-cell lines as well as resting and cell_lineactivated immature (CCRF-CEM) T-cell lines . |
| 0.7188 | 1.0000 | 1.0000 | Tandem copies of this DNAenhancer functioned synergistically in mature (Jurkat) T-cell lines as well as resting and activated immature (CCRF-CEM) T-cell lines . |
| Tandem copies of this enhancer functioned synergistically in mature (Jurkat) T-cell lines as well as resting and activated cell_lineimmature (CCRF-CEM) T-cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9200 | 20.7034 | 10.6120 | Mutation of the DNATCF-1 alpha binding site diminished enhancer activity and disrupted the synergism observed in vivo between tandem enhancer repeats . |
| 3.3961 | 20.9105 | 10.6227 | Mutation of the TCF-1 alpha binding site diminished enhancer activity and disrupted the synergism observed in vivo between DNAtandem enhancer repeats . |
| 1.8406 | 20.7959 | 0.9626 | Mutation of the proteinTCF-1 alpha binding site diminished enhancer activity and disrupted the synergism observed in vivo between tandem enhancer repeats . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8029 | 20.9447 | 10.6107 | The TCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells , confirming that TCF-1 alpha is a proteinT-cell-specific transcription factor . |
| 2.3938 | 10.3493 | 10.0496 | The DNATCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells , confirming that TCF-1 alpha is a T-cell-specific transcription factor . |
| 1.6047 | 10.3821 | 1.0000 | The TCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from cell_lineJurkat but not HeLa cells , confirming that TCF-1 alpha is a T-cell-specific transcription factor . |
| 1.4169 | 10.9917 | 1.0000 | The TCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells , confirming that proteinTCF-1 alpha is a T-cell-specific transcription factor . |
| 1.4011 | 10.5772 | 0.9998 | The TCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not cell_lineHeLa cells , confirming that TCF-1 alpha is a T-cell-specific transcription factor . |
| 1.2861 | 10.4171 | 0.7552 | The proteinTCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells , confirming that TCF-1 alpha is a T-cell-specific transcription factor . |
| 3.4546 | 20.4041 | 10.9241 | The TCF-1 alpha binding site was also required for DNATCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells , confirming that TCF-1 alpha is a T-cell-specific transcription factor . |
| The TCF-1 alpha binding site was also required for proteinTCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells , confirming that TCF-1 alpha is a T-cell-specific transcription factor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4847 | 20.8644 | 10.5713 | Curiously, the TCF-1 alpha binding element was inactive in vivo when removed from its neighboring elements on the DNATCR alpha enhancer and positioned in one or more copies upstream of a heterologous promoter . |
| 2.0336 | 20.9452 | 0.9999 | Curiously, the TCF-1 alpha binding element was inactive in vivo when removed from its neighboring elements on the TCR alpha enhancer and positioned in one or more copies upstream of a DNAheterologous promoter . |
| 2.0236 | 20.9423 | 0.9234 | Curiously, the proteinTCF-1 alpha binding element was inactive in vivo when removed from its neighboring elements on the TCR alpha enhancer and positioned in one or more copies upstream of a heterologous promoter . |
| 3.2512 | 20.9481 | 10.4034 | Curiously, the DNATCF-1 alpha binding element was inactive in vivo when removed from its neighboring elements on the TCR alpha enhancer and positioned in one or more copies upstream of a heterologous promoter . |
| Curiously, the TCF-1 alpha binding element was inactive in vivo when removed from its neighboring elements on the proteinTCR alpha enhancer and positioned in one or more copies upstream of a heterologous promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4898 | 20.5333 | 10.0562 | Thus, the transcriptional activity of TCF-1 alpha appears to depend on the TCF-2 alpha and T alpha 1 ( CREB ) transcription factors and the context of its binding site within the DNATCR alpha enhancer . |
| 1.8048 | 20.9855 | 0.9998 | Thus, the transcriptional activity of proteinTCF-1 alpha appears to depend on the TCF-2 alpha and T alpha 1 ( CREB ) transcription factors and the context of its binding site within the TCR alpha enhancer . |
| 1.5370 | 20.2946 | 0.9718 | Thus, the transcriptional activity of TCF-1 alpha appears to depend on the proteinTCF-2 alpha and T alpha 1 ( CREB ) transcription factors and the context of its binding site within the TCR alpha enhancer . |
| 0.9462 | 1.0000 | 0.9843 | Thus, the transcriptional activity of TCF-1 alpha appears to depend on the TCF-2 alpha and T alpha 1 ( proteinCREB ) transcription factors and the context of its binding site within the TCR alpha enhancer . |
| 0.5928 | 0.6259 | 0.9965 | Thus, the transcriptional activity of TCF-1 alpha appears to depend on the TCF-2 alpha and T alpha 1 ( CREB ) proteintranscription factors and the context of its binding site within the TCR alpha enhancer . |
| 1.6741 | 20.1656 | 0.9997 | Thus, the transcriptional activity of TCF-1 alpha appears to depend on the TCF-2 alpha and T alpha 1 ( CREB ) transcription factors and the context of its DNAbinding site within the TCR alpha enhancer . |
| 1.5777 | 0.9606 | 20.9651 | Thus, the transcriptional activity of TCF-1 alpha appears to depend on the proteinTCF-2 alpha and T alpha 1 ( CREB ) transcription factors and the context of its binding site within the TCR alpha enhancer . |
| 0.6646 | 1.0000 | 0.9844 | Thus, the transcriptional activity of TCF-1 alpha appears to depend on the TCF-2 alpha and proteinT alpha 1 ( CREB ) transcription factors and the context of its binding site within the TCR alpha enhancer . |
| Thus, the transcriptional activity of TCF-1 alpha appears to depend on the TCF-2 alpha and T alpha 1 ( CREB ) transcription factors and the context of its binding site within the proteinTCR alpha enhancer . | |||
| Thus, the transcriptional activity of TCF-1 alpha appears to depend on the TCF-2 alpha and proteinT alpha 1 ( CREB ) transcription factors and the context of its binding site within the TCR alpha enhancer . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.6922 | 30.4532 | 20.2512 | Tandem AP-1-binding sites within the DNAhuman beta-globin dominant control region function as an inducible enhancer in erythroid cells . |
| 1.7436 | 20.1464 | 0.9996 | Tandem AP-1-binding sites within the human beta-globin dominant control region function as an DNAinducible enhancer in erythroid cells . |
| 1.4735 | 0.9972 | 10.7146 | DNATandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells . |
| 1.2178 | 10.3898 | 0.9990 | Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in cell_typeerythroid cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1384 | 20.2575 | 10.9778 | A powerful enhancer has been mapped to an DNA18-bp DNA segment located 11 kb 5' to the human epsilon-globin gene within the dominant control or locus-activating region . |
| 2.7516 | 10.8935 | 10.7482 | A powerful enhancer has been mapped to an 18-bp DNA segment located 11 kb 5' to the DNAhuman epsilon-globin gene within the dominant control or locus-activating region . |
| 1.3838 | 10.8533 | 0.9997 | A powerful enhancer has been mapped to an 18-bp DNA segment located 11 kb 5' to the human epsilon-globin gene within the dominant control or DNAlocus-activating region . |
| 2.1285 | 10.8283 | 10.1697 | A powerful enhancer has been mapped to an 18-bp DNA segment located DNA11 kb 5' to the human epsilon-globin gene within the dominant control or locus-activating region . |
| 1.6282 | 10.4153 | 1.0000 | A powerful DNAenhancer has been mapped to an 18-bp DNA segment located 11 kb 5' to the human epsilon-globin gene within the dominant control or locus-activating region . |
| A powerful enhancer has been mapped to an 18-bp DNA segment located 11 kb 5' to the human epsilon-globin gene within the DNAdominant control or locus-activating region . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6503 | 20.9002 | 10.8859 | This enhancer is inducible in cell_lineK562 human erythroleukemia cells , increasing linked gamma-globin promoter /luciferase gene expression to 170-fold over an enhancerless construct . |
| 1.8748 | 20.6221 | 0.9997 | This enhancer is inducible in K562 human erythroleukemia cells , increasing linked gamma-globin promoter /luciferase gene expression to 170-fold over an DNAenhancerless construct . |
| 1.8253 | 20.9020 | 0.9456 | This enhancer is inducible in K562 human erythroleukemia cells , increasing linked DNAgamma-globin promoter /luciferase gene expression to 170-fold over an enhancerless construct . |
| 0.8268 | 0.9998 | 1.0000 | This DNAenhancer is inducible in K562 human erythroleukemia cells , increasing linked gamma-globin promoter /luciferase gene expression to 170-fold over an enhancerless construct . |
| 3.8810 | 20.9508 | 10.1975 | This enhancer is inducible in K562 human erythroleukemia cells , increasing linked DNAgamma-globin promoter /luciferase gene expression to 170-fold over an enhancerless construct . |
| This enhancer is inducible in K562 human erythroleukemia cells , increasing linked gamma-globin promoter protein/luciferase gene expression to 170-fold over an enhancerless construct . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9213 | 1.0000 | 1.0000 | The DNAenhancer consists of tandem AP-1-binding sites , phased 10 bp apart, which are both required for full activity. |
| 2.3913 | 20.1718 | 0.9999 | The enhancer consists of tandem DNAAP-1-binding sites , phased 10 bp apart, which are both required for full activity. |
| The enhancer consists of DNAtandem AP-1-binding sites , phased 10 bp apart, which are both required for full activity. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5663 | 20.1593 | 10.6332 | DNA-protein binding assays with nuclear extracts from induced cells demonstrate a proteinhigh molecular weight complex on the enhancer . |
| 1.5777 | 10.5973 | 1.0000 | DNA-protein binding assays with nuclear extracts from induced cells demonstrate a high molecular weight complex on the DNAenhancer . |
| 1.9573 | 20.1269 | 0.9999 | DNA-protein binding assays with nuclear extracts from cell_typeinduced cells demonstrate a high molecular weight complex on the enhancer . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6173 | 10.9810 | 1.0000 | The formation of this complex also requires both DNAAP-1 sites and correlates with maximal enhancer activity . |
| The formation of this complex also requires both AP-1 sites and correlates with maximal DNAenhancer activity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4430 | 20.5821 | 1.0000 | Induction of the enhancer may have a role in the increase in DNAglobin gene transcription that characterizes erythroid maturation . |
| 1.5588 | 10.5281 | 1.0000 | Induction of the DNAenhancer may have a role in the increase in globin gene transcription that characterizes erythroid maturation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7342 | 20.8979 | 10.5153 | Enhancer activity appears to be mediated by the binding of a complex of proteins from the jun and fos families to DNAtandem AP-1 consensus sequences . |
| Enhancer activity appears to be mediated by the binding of a complex of proteins from the DNAjun and fos families to tandem AP-1 consensus sequences . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1680 | 30.1393 | 10.7497 | Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the proteinlymphoid cell-specific factor OTF2 . |
| 3.5261 | 20.8821 | 10.6941 | Identification of a novel factor that interacts with an DNAimmunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2 . |
| 2.0310 | 20.4799 | 0.9999 | Identification of a proteinnovel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor OTF2 . |
| 0.9559 | 0.9999 | 1.0000 | Identification of a novel factor that interacts with an immunoglobulin heavy-chain promoter and stimulates transcription in conjunction with the lymphoid cell-specific factor proteinOTF2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4432 | 20.9336 | 10.9922 | The tissue-specific expression of the DNAMOPC 141 immunoglobulin heavy-chain gene was studied by using in vitro transcription . |
| 1.4192 | 0.9969 | 10.7822 | The tissue-specific expression of the MOPC 141 DNAimmunoglobulin heavy-chain gene was studied by using in vitro transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1540 | 20.7358 | 0.9995 | B-cell-specific transcription of this gene was dependent on the DNAoctamer element 5'-ATGCAAAG-3' , located in the upstream region of this promoter and in the promoters of all other immunoglobulin heavy- and light- chain genes . |
| 1.4685 | 10.8526 | 0.9999 | B-cell-specific transcription of this gene was dependent on the octamer element 5'-ATGCAAAG-3' , located in the DNAupstream region of this promoter and in the promoters of all other immunoglobulin heavy- and light- chain genes . |
| 0.9130 | 1.0000 | 1.0000 | B-cell-specific transcription of this gene was dependent on the octamer element 5'-ATGCAAAG-3' , located in the upstream region of this promoter and in the DNApromoters of all other immunoglobulin heavy- and light- chain genes . |
| 0.9130 | 1.0000 | 1.0000 | B-cell-specific transcription of this gene was dependent on the octamer element 5'-ATGCAAAG-3' , located in the upstream region of this DNApromoter and in the promoters of all other immunoglobulin heavy- and light- chain genes . |
| 5.3699 | 20.9079 | 20.4615 | B-cell-specific transcription of this gene was dependent on the octamer element 5'-ATGCAAAG-3' , located in the upstream region of this promoter and in the promoters of all other DNAimmunoglobulin heavy- and light- chain genes . |
| 0.7793 | 0.9998 | 1.0000 | B-cell-specific transcription of this gene was dependent on the octamer element DNA5'-ATGCAAAG-3' , located in the upstream region of this promoter and in the promoters of all other immunoglobulin heavy- and light- chain genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4818 | 20.9387 | 10.9587 | The interaction of purified octamer transcription factors 1 and 2 ( OTF1 and OTF2 ) with the DNAMOPC 141 promoter was studied by using electrophoretic mobility shift assays and DNase I footprinting . |
| 2.0519 | 20.2004 | 0.9999 | The interaction of purified octamer transcription factors 1 and 2 ( OTF1 and OTF2 ) with the MOPC 141 promoter was studied by using electrophoretic mobility shift assays and proteinDNase I footprinting . |
| 0.9641 | 1.0000 | 1.0000 | The interaction of purified octamer transcription factors 1 and 2 ( OTF1 and proteinOTF2 ) with the MOPC 141 promoter was studied by using electrophoretic mobility shift assays and DNase I footprinting . |
| 0.9456 | 1.0000 | 1.0000 | The interaction of purified octamer transcription factors 1 and 2 ( proteinOTF1 and OTF2 ) with the MOPC 141 promoter was studied by using electrophoretic mobility shift assays and DNase I footprinting . |
| 0.5377 | 0.9982 | 0.9996 | The interaction of purified octamer proteintranscription factors 1 and 2 ( OTF1 and OTF2 ) with the MOPC 141 promoter was studied by using electrophoretic mobility shift assays and DNase I footprinting . |
| 5.2719 | 30.0278 | 10.5426 | The interaction of proteinpurified octamer transcription factors 1 and 2 ( OTF1 and OTF2 ) with the MOPC 141 promoter was studied by using electrophoretic mobility shift assays and DNase I footprinting . |
| The interaction of purified proteinoctamer transcription factors 1 and 2 ( OTF1 and OTF2 ) with the MOPC 141 promoter was studied by using electrophoretic mobility shift assays and DNase I footprinting . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1957 | 20.9624 | 0.9999 | Purified OTF1 from HeLa cells and OTF1 and OTF2 from B cells bound to identical sequences within the DNAheavy-chain promoter . |
| 1.7207 | 10.2083 | 1.0000 | Purified proteinOTF1 from HeLa cells and OTF1 and OTF2 from B cells bound to identical sequences within the heavy-chain promoter . |
| 1.5456 | 10.3825 | 0.9998 | Purified OTF1 from HeLa cells and OTF1 and OTF2 from cell_typeB cells bound to identical sequences within the heavy-chain promoter . |
| 1.5283 | 10.8293 | 0.9998 | Purified OTF1 from cell_lineHeLa cells and OTF1 and OTF2 from B cells bound to identical sequences within the heavy-chain promoter . |
| 0.9518 | 1.0000 | 1.0000 | Purified OTF1 from HeLa cells and OTF1 and proteinOTF2 from B cells bound to identical sequences within the heavy-chain promoter . |
| 0.9275 | 1.0000 | 1.0000 | Purified OTF1 from HeLa cells and proteinOTF1 and OTF2 from B cells bound to identical sequences within the heavy-chain promoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2650 | 20.8375 | 0.9996 | The OTF interactions we observed extended over the DNAheptamer element 5'-CTCAGGA-3' , and it seems likely that the binding of the purified factors involves cooperation between octamer and heptamer sites in this promoter . |
| 2.2463 | 20.3306 | 1.0000 | The OTF interactions we observed extended over the heptamer element 5'-CTCAGGA-3' , and it seems likely that the binding of the proteinpurified factors involves cooperation between octamer and heptamer sites in this promoter . |
| 1.7858 | 10.2775 | 1.0000 | The OTF interactions we observed extended over the heptamer element 5'-CTCAGGA-3' , and it seems likely that the binding of the purified factors involves cooperation between octamer and heptamer sites in this DNApromoter . |
| 1.5802 | 10.3593 | 1.0000 | The OTF interactions we observed extended over the heptamer element 5'-CTCAGGA-3' , and it seems likely that the binding of the purified factors involves cooperation between octamer and DNAheptamer sites in this promoter . |
| 0.9156 | 1.0000 | 1.0000 | The proteinOTF interactions we observed extended over the heptamer element 5'-CTCAGGA-3' , and it seems likely that the binding of the purified factors involves cooperation between octamer and heptamer sites in this promoter . |
| 0.8925 | 0.9999 | 1.0000 | The OTF interactions we observed extended over the heptamer element DNA5'-CTCAGGA-3' , and it seems likely that the binding of the purified factors involves cooperation between octamer and heptamer sites in this promoter . |
| 0.8843 | 1.0000 | 1.0000 | The OTF interactions we observed extended over the heptamer element 5'-CTCAGGA-3' , and it seems likely that the binding of the purified factors involves cooperation between DNAoctamer and heptamer sites in this promoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2601 | 20.1730 | 0.9999 | In addition to these elements, we identified a second DNAregulatory element , the N element with the sequence 5'-GGAACCTCCCCC-3' . |
| 1.5428 | 10.6488 | 1.0000 | In addition to these elements, we identified a second regulatory element , the DNAN element with the sequence 5'-GGAACCTCCCCC-3' . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4340 | 20.2322 | 1.0000 | The N element could independently mediate low levels of transcription in both B-cell and HeLa-cell extracts , and, in conjunction with the DNAoctamer element , it can promote high levels of transcription in B-cell extracts . |
| 1.6679 | 10.9033 | 1.0000 | The DNAN element could independently mediate low levels of transcription in both B-cell and HeLa-cell extracts , and, in conjunction with the octamer element , it can promote high levels of transcription in B-cell extracts . |
| 1.5547 | 10.8856 | 0.9997 | The N element could independently mediate low levels of transcription in both B-cell and HeLa-cell extracts , and, in conjunction with the octamer element , it can promote high levels of transcription in cell_typeB-cell extracts . |
| 0.6017 | 0.9998 | 0.9999 | The N element could independently mediate low levels of transcription in both B-cell and cell_lineHeLa-cell extracts , and, in conjunction with the octamer element , it can promote high levels of transcription in B-cell extracts . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6312 | 10.8649 | 0.9999 | The DNAN element bound a transcription factor , NTF , that is ubiquitous in cell-type distribution , and NTF was distinct from any of the previously described proteins that bind to similar sequences. |
| 1.5389 | 10.6321 | 1.0000 | The N element bound a proteintranscription factor , NTF , that is ubiquitous in cell-type distribution , and NTF was distinct from any of the previously described proteins that bind to similar sequences. |
| 0.9495 | 1.0000 | 1.0000 | The N element bound a transcription factor , proteinNTF , that is ubiquitous in cell-type distribution , and NTF was distinct from any of the previously described proteins that bind to similar sequences. |
| 0.9184 | 1.0000 | 1.0000 | The N element bound a transcription factor , NTF , that is ubiquitous in cell-type distribution , and proteinNTF was distinct from any of the previously described proteins that bind to similar sequences. |
| The N element bound a transcription factor , NTF , that is ubiquitous in proteincell-type distribution , and NTF was distinct from any of the previously described proteins that bind to similar sequences. | |||
| The N element bound a transcription factor , NTF , that is ubiquitous in cell-type distribution , and NTF was distinct from any of the proteinpreviously described proteins that bind to similar sequences. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8677 | 20.6418 | 10.6470 | Based on these results, we propose that NTF and OTF2 interactions (both with their DNAcognate DNA elements and possibly at the protein-protein level ) may be critical to B-cell-specific expression and that these interactions provide additional pathways for regulating gene expression . |
| 0.9687 | 1.0000 | 1.0000 | Based on these results, we propose that NTF and proteinOTF2 interactions (both with their cognate DNA elements and possibly at the protein-protein level ) may be critical to B-cell-specific expression and that these interactions provide additional pathways for regulating gene expression . |
| 0.9252 | 1.0000 | 1.0000 | Based on these results, we propose that proteinNTF and OTF2 interactions (both with their cognate DNA elements and possibly at the protein-protein level ) may be critical to B-cell-specific expression and that these interactions provide additional pathways for regulating gene expression . |
| 0.6752 | 0.9999 | 0.9999 | Based on these results, we propose that NTF and OTF2 interactions (both with their cognate DNADNA elements and possibly at the protein-protein level ) may be critical to B-cell-specific expression and that these interactions provide additional pathways for regulating gene expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.0998 | 30.1762 | 20.1792 | NF-kappa B as inducible transcriptional activator of the DNAgranulocyte-macrophage colony-stimulating factor gene . |
| 0.8771 | 0.9999 | 1.0000 | proteinNF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene . |
| NF-kappa B as inducible proteintranscriptional activator of the granulocyte-macrophage colony-stimulating factor gene . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6848 | 20.6207 | 10.3969 | The expression of the gene encoding the proteingranulocyte- macrophage colony-stimulating factor ( GM-CSF ) is induced upon activation of T cells with phytohemagglutinin and active phorbolester and upon expression of tax1 , a transactivating protein of the human T-cell leukemia virus type I . |
| 2.3550 | 20.5247 | 0.9999 | The expression of the gene encoding the granulocyte- macrophage colony-stimulating factor ( GM-CSF ) is induced upon activation of cell_typeT cells with phytohemagglutinin and active phorbolester and upon expression of tax1 , a transactivating protein of the human T-cell leukemia virus type I . |
| 1.7484 | 10.0079 | 1.0000 | The expression of the gene encoding the granulocyte- macrophage colony-stimulating factor ( GM-CSF ) is induced upon activation of T cells with proteinphytohemagglutinin and active phorbolester and upon expression of tax1 , a transactivating protein of the human T-cell leukemia virus type I . |
| 1.6416 | 10.9409 | 1.0000 | The expression of the gene encoding the granulocyte- macrophage colony-stimulating factor ( GM-CSF ) is induced upon activation of T cells with phytohemagglutinin and active phorbolester and upon expression of proteintax1 , a transactivating protein of the human T-cell leukemia virus type I . |
| 1.5482 | 10.1856 | 0.9999 | The expression of the gene encoding the granulocyte- macrophage colony-stimulating factor ( GM-CSF ) is induced upon activation of T cells with phytohemagglutinin and active phorbolester and upon expression of tax1 , a proteintransactivating protein of the human T-cell leukemia virus type I . |
| 0.9781 | 1.0000 | 1.0000 | The expression of the gene encoding the granulocyte- macrophage colony-stimulating factor ( proteinGM-CSF ) is induced upon activation of T cells with phytohemagglutinin and active phorbolester and upon expression of tax1 , a transactivating protein of the human T-cell leukemia virus type I . |
| The expression of the gene encoding the granulocyte- proteinmacrophage colony-stimulating factor ( GM-CSF ) is induced upon activation of T cells with phytohemagglutinin and active phorbolester and upon expression of tax1 , a transactivating protein of the human T-cell leukemia virus type I . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8150 | 20.7154 | 10.6720 | The same agents induce transcription from the interleukin-2 receptor alpha-chain and interleukin-2 genes , depending on promoter elements that bind the inducible transcription factor NF-kappa B (or an proteinNF-kappa B -like factor ). |
| 2.0301 | 20.2280 | 0.9732 | The same agents induce transcription from the interleukin-2 receptor alpha-chain and interleukin-2 genes , depending on promoter elements that bind the inducible transcription factor NF-kappa B (or an proteinNF-kappa B -like factor ). |
| 1.3790 | 10.9269 | 0.9998 | The same agents induce transcription from the interleukin-2 receptor alpha-chain and interleukin-2 genes , depending on DNApromoter elements that bind the inducible transcription factor NF-kappa B (or an NF-kappa B -like factor ). |
| 0.8786 | 0.9986 | 0.9999 | The same agents induce transcription from the interleukin-2 receptor alpha-chain and interleukin-2 genes , depending on promoter elements that bind the inducible transcription factor proteinNF-kappa B (or an NF-kappa B -like factor ). |
| 3.4847 | 20.8460 | 10.7448 | The same agents induce transcription from the proteininterleukin-2 receptor alpha-chain and interleukin-2 genes , depending on promoter elements that bind the inducible transcription factor NF-kappa B (or an NF-kappa B -like factor ). |
| 1.9945 | 20.1564 | 0.9966 | The same agents induce transcription from the proteininterleukin-2 receptor alpha-chain and interleukin-2 genes , depending on promoter elements that bind the inducible transcription factor NF-kappa B (or an NF-kappa B -like factor ). |
| 1.4562 | 10.6980 | 0.9999 | The same agents induce transcription from the interleukin-2 receptor alpha-chain and DNAinterleukin-2 genes , depending on promoter elements that bind the inducible transcription factor NF-kappa B (or an NF-kappa B -like factor ). |
| 1.4105 | 10.6359 | 0.9995 | The same agents induce transcription from the interleukin-2 receptor alpha-chain and interleukin-2 genes , depending on promoter elements that bind the inducible proteintranscription factor NF-kappa B (or an NF-kappa B -like factor ). |
| The same agents induce transcription from the interleukin-2 receptor alpha-chain and interleukin-2 genes , depending on promoter elements that bind the proteininducible transcription factor NF-kappa B (or an NF-kappa B -like factor ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0992 | 20.7710 | 0.9996 | We therefore tested the possibility that the GM-CSF gene is also regulated by a cognate motif for the proteinNF-kappa B transcription factor . |
| 2.0588 | 20.7360 | 1.0000 | We therefore tested the possibility that the DNAGM-CSF gene is also regulated by a cognate motif for the NF-kappa B transcription factor . |
| 1.9184 | 20.7951 | 0.9883 | We therefore tested the possibility that the proteinGM-CSF gene is also regulated by a cognate motif for the NF-kappa B transcription factor . |
| 1.9094 | 20.6605 | 0.9954 | We therefore tested the possibility that the GM-CSF gene is also regulated by a cognate motif for the proteinNF-kappa B transcription factor . |
| 0.8766 | 0.9990 | 0.9998 | We therefore tested the possibility that the GM-CSF gene is also regulated by a cognate motif for the NF-kappa B proteintranscription factor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3023 | 30.2790 | 10.3731 | A recent functional analysis by Miyatake et al. (S. Miyatake, M. Seiki, M. Yoshida, and K. Arai, Mol. Cell. Biol. 8:5581-5587, 1988) described a short promoter region in the GM-CSF gene that conferred strong inducibility by T-cell-activating signals and tax1 , but no DNANF-kappa B -binding motifs were identified. |
| 2.2191 | 20.6996 | 1.0000 | A recent functional analysis by Miyatake et al. (S. Miyatake, M. Seiki, M. Yoshida, and K. Arai, Mol. Cell. Biol. 8:5581-5587, 1988) described a short promoter region in the DNAGM-CSF gene that conferred strong inducibility by T-cell-activating signals and tax1 , but no NF-kappa B -binding motifs were identified. |
| 2.1225 | 20.0629 | 0.9589 | A recent functional analysis by Miyatake et al. (S. Miyatake, M. Seiki, M. Yoshida, and K. Arai, Mol. Cell. Biol. 8:5581-5587, 1988) described a short promoter region in the GM-CSF gene that conferred strong inducibility by T-cell-activating signals and tax1 , but no proteinNF-kappa B -binding motifs were identified. |
| 2.0372 | 20.9234 | 0.9920 | A recent functional analysis by Miyatake et al. (S. Miyatake, M. Seiki, M. Yoshida, and K. Arai, Mol. Cell. Biol. 8:5581-5587, 1988) described a short promoter region in the proteinGM-CSF gene that conferred strong inducibility by T-cell-activating signals and tax1 , but no NF-kappa B -binding motifs were identified. |
| 1.6402 | 10.9902 | 1.0000 | A recent functional analysis by Miyatake et al. (S. Miyatake, M. Seiki, M. Yoshida, and K. Arai, Mol. Cell. Biol. 8:5581-5587, 1988) described a short promoter region in the GM-CSF gene that conferred strong inducibility by T-cell-activating signals and proteintax1 , but no NF-kappa B -binding motifs were identified. |
| 2.2504 | 20.6176 | 0.9999 | A recent functional analysis by Miyatake et al. (S. Miyatake, M. Seiki, M. Yoshida, and K. Arai, Mol. Cell. Biol. 8:5581-5587, 1988) described a short DNApromoter region in the GM-CSF gene that conferred strong inducibility by T-cell-activating signals and tax1 , but no NF-kappa B -binding motifs were identified. |
| A recent functional analysis by Miyatake et al. (S. Miyatake, M. Seiki, M. Yoshida, and K. Arai, Mol. Cell. Biol. 8:5581-5587, 1988) described a DNAshort promoter region in the GM-CSF gene that conferred strong inducibility by T-cell-activating signals and tax1 , but no NF-kappa B -binding motifs were identified. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4517 | 20.3441 | 10.7520 | Using electrophoretic mobility shift assays , we showed binding of purified human NF-kappa B and of the NF-kappa B activated in cell_lineJurkat T cells to an oligonucleotide comprising the GM-CSF promoter element responsible for mediating responsiveness to T-cell-activating signals and tax1 . |
| 3.0537 | 20.8388 | 10.5741 | Using electrophoretic mobility shift assays , we showed binding of purified human NF-kappa B and of the NF-kappa B activated in Jurkat T cells to an oligonucleotide comprising the DNAGM-CSF promoter element responsible for mediating responsiveness to T-cell-activating signals and tax1 . |
| 1.9986 | 20.0737 | 0.9967 | Using electrophoretic mobility shift assays , we showed binding of purified human NF-kappa B and of the NF-kappa B activated in Jurkat T cells to an oligonucleotide comprising the proteinGM-CSF promoter element responsible for mediating responsiveness to T-cell-activating signals and tax1 . |
| 1.4869 | 10.8160 | 1.0000 | Using electrophoretic mobility shift assays , we showed binding of purified human NF-kappa B and of the proteinNF-kappa B activated in Jurkat T cells to an oligonucleotide comprising the GM-CSF promoter element responsible for mediating responsiveness to T-cell-activating signals and tax1 . |
| 1.4353 | 10.4535 | 1.0000 | Using electrophoretic mobility shift assays , we showed binding of purified human NF-kappa B and of the NF-kappa B activated in Jurkat T cells to an oligonucleotide comprising the GM-CSF promoter element responsible for mediating responsiveness to T-cell-activating signals and proteintax1 . |
| 0.9078 | 0.9998 | 1.0000 | Using electrophoretic mobility shift assays , we showed binding of purified human proteinNF-kappa B and of the NF-kappa B activated in Jurkat T cells to an oligonucleotide comprising the GM-CSF promoter element responsible for mediating responsiveness to T-cell-activating signals and tax1 . |
| 4.0037 | 20.7773 | 10.9340 | Using electrophoretic mobility shift assays , we showed binding of proteinpurified human NF-kappa B and of the NF-kappa B activated in Jurkat T cells to an oligonucleotide comprising the GM-CSF promoter element responsible for mediating responsiveness to T-cell-activating signals and tax1 . |
| Using electrophoretic mobility shift assays , we showed binding of purified human NF-kappa B and of the NF-kappa B activated in Jurkat cell_typeT cells to an oligonucleotide comprising the GM-CSF promoter element responsible for mediating responsiveness to T-cell-activating signals and tax1 . | |||
| Using electrophoretic mobility shift assays , we showed binding of purified proteinhuman NF-kappa B and of the NF-kappa B activated in Jurkat T cells to an oligonucleotide comprising the GM-CSF promoter element responsible for mediating responsiveness to T-cell-activating signals and tax1 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4069 | 30.7928 | 10.7856 | As shown by a methylation interference analysis and oligonucleotide competition experiments, purified NF-kappa B binds at positions -82 to -91 ( GGGAACTACC ) of the GM-CSF promoter sequence with an affinity similar to that with which it binds to the biologically functional kappa B motif in the DNAbeta interferon promoter ( GGGAAATTCC ). |
| 0.7958 | 1.0000 | 1.0000 | As shown by a methylation interference analysis and oligonucleotide competition experiments, purified proteinNF-kappa B binds at positions -82 to -91 ( GGGAACTACC ) of the GM-CSF promoter sequence with an affinity similar to that with which it binds to the biologically functional kappa B motif in the beta interferon promoter ( GGGAAATTCC ). |
| 4.5961 | 20.8936 | 10.6603 | As shown by a methylation interference analysis and oligonucleotide competition experiments, proteinpurified NF-kappa B binds at positions -82 to -91 ( GGGAACTACC ) of the GM-CSF promoter sequence with an affinity similar to that with which it binds to the biologically functional kappa B motif in the beta interferon promoter ( GGGAAATTCC ). |
| 4.4144 | 20.5154 | 10.9281 | As shown by a methylation interference analysis and oligonucleotide competition experiments, purified NF-kappa B binds at positions DNA-82 to -91 ( GGGAACTACC ) of the GM-CSF promoter sequence with an affinity similar to that with which it binds to the biologically functional kappa B motif in the beta interferon promoter ( GGGAAATTCC ). |
| 3.7365 | 20.6228 | 10.5942 | As shown by a methylation interference analysis and oligonucleotide competition experiments, purified NF-kappa B binds at positions -82 to -91 ( GGGAACTACC ) of the DNAGM-CSF promoter sequence with an affinity similar to that with which it binds to the biologically functional kappa B motif in the beta interferon promoter ( GGGAAATTCC ). |
| 3.6374 | 20.9186 | 10.7821 | As shown by a methylation interference analysis and oligonucleotide competition experiments, purified NF-kappa B binds at positions -82 to -91 ( GGGAACTACC ) of the GM-CSF promoter sequence with an affinity similar to that with which it binds to the biologically functional DNAkappa B motif in the beta interferon promoter ( GGGAAATTCC ). |
| As shown by a methylation interference analysis and oligonucleotide competition experiments, purified NF-kappa B binds at positions -82 to -91 ( GGGAACTACC ) of the proteinGM-CSF promoter sequence with an affinity similar to that with which it binds to the biologically functional kappa B motif in the beta interferon promoter ( GGGAAATTCC ). | |||
| As shown by a methylation interference analysis and oligonucleotide competition experiments, purified NF-kappa B binds at positions -82 to -91 ( GGGAACTACC ) of the GM-CSF promoter sequence with an affinity similar to that with which it binds to the DNAbiologically functional kappa B motif in the beta interferon promoter ( GGGAAATTCC ). | |||
| As shown by a methylation interference analysis and oligonucleotide competition experiments, purified NF-kappa B binds at positions -82 to -91 ( GGGAACTACC ) of the DNAGM-CSF promoter sequence with an affinity similar to that with which it binds to the biologically functional kappa B motif in the beta interferon promoter ( GGGAAATTCC ). | |||
| As shown by a methylation interference analysis and oligonucleotide competition experiments, purified NF-kappa B binds at DNApositions -82 to -91 ( GGGAACTACC ) of the GM-CSF promoter sequence with an affinity similar to that with which it binds to the biologically functional kappa B motif in the beta interferon promoter ( GGGAAATTCC ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.7481 | 10.9692 | 10.6344 | Two DNAkappa B-like motifs at positions -98 to -108 of the GM-CSF promoter were also recognized but with much lower affinities. |
| 1.4071 | 10.8294 | 1.0000 | Two kappa B-like motifs at positions -98 to -108 of the DNAGM-CSF promoter were also recognized but with much lower affinities. |
| 2.9650 | 10.8475 | 10.5471 | Two kappa B-like motifs at positions DNA-98 to -108 of the GM-CSF promoter were also recognized but with much lower affinities. |
| Two kappa B-like motifs at positions -98 to -108 of the proteinGM-CSF promoter were also recognized but with much lower affinities. | |||
| Two kappa B-like motifs at DNApositions -98 to -108 of the GM-CSF promoter were also recognized but with much lower affinities. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6115 | 20.4646 | 10.6479 | Our data provide strong evidence that the expression of the GM-CSF gene following T-cell activation is controlled by binding of the NF-kappa B transcription factor to a DNAhigh-affinity binding site in the GM-CSF promoter . |
| 2.1301 | 20.1359 | 0.9995 | Our data provide strong evidence that the expression of the GM-CSF gene following T-cell activation is controlled by binding of the proteinNF-kappa B transcription factor to a high-affinity binding site in the GM-CSF promoter . |
| 2.1143 | 20.8672 | 1.0000 | Our data provide strong evidence that the expression of the DNAGM-CSF gene following T-cell activation is controlled by binding of the NF-kappa B transcription factor to a high-affinity binding site in the GM-CSF promoter . |
| 2.0838 | 20.5011 | 0.9998 | Our data provide strong evidence that the expression of the GM-CSF gene following T-cell activation is controlled by binding of the NF-kappa B transcription factor to a high-affinity binding site in the DNAGM-CSF promoter . |
| 1.9799 | 20.8586 | 0.9904 | Our data provide strong evidence that the expression of the proteinGM-CSF gene following T-cell activation is controlled by binding of the NF-kappa B transcription factor to a high-affinity binding site in the GM-CSF promoter . |
| 1.9446 | 20.9526 | 0.9863 | Our data provide strong evidence that the expression of the GM-CSF gene following T-cell activation is controlled by binding of the NF-kappa B transcription factor to a high-affinity binding site in the proteinGM-CSF promoter . |
| 0.8584 | 0.9963 | 0.9999 | Our data provide strong evidence that the expression of the GM-CSF gene following T-cell activation is controlled by binding of the NF-kappa B proteintranscription factor to a high-affinity binding site in the GM-CSF promoter . |
| Our data provide strong evidence that the expression of the GM-CSF gene following T-cell activation is controlled by binding of the proteinNF-kappa B transcription factor to a high-affinity binding site in the GM-CSF promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6657 | 20.5457 | 20.0060 | Effects of mitogenic agents upon glucocorticoid action in cell_typehuman tonsillar T- lymphocytes . |
| 1.7001 | 20.3272 | 10.7488 | Effects of mitogenic agents upon glucocorticoid action in cell_typehuman tonsillar T- lymphocytes . |
| Effects of mitogenic agents upon glucocorticoid action in human tonsillar T- cell_typelymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0129 | 20.2382 | 20.2375 | The treatment of cell_typehuman tonsillar T- lymphocytes with 4-phorbol 12-myristate 13-acetate ( PMA ), resulted in about two fold increase in glucocorticoid receptor ( GR ) number , without any significant change in the receptor affinity . |
| 2.2927 | 20.9990 | 1.0000 | The treatment of human tonsillar T- lymphocytes with 4-phorbol 12-myristate 13-acetate ( PMA ), resulted in about two fold increase in proteinglucocorticoid receptor ( GR ) number , without any significant change in the receptor affinity . |
| 0.9810 | 1.0000 | 1.0000 | The treatment of human tonsillar T- lymphocytes with 4-phorbol 12-myristate 13-acetate ( PMA ), resulted in about two fold increase in glucocorticoid receptor ( proteinGR ) number , without any significant change in the receptor affinity . |
| 1.9532 | 20.3622 | 10.8130 | The treatment of cell_typehuman tonsillar T- lymphocytes with 4-phorbol 12-myristate 13-acetate ( PMA ), resulted in about two fold increase in glucocorticoid receptor ( GR ) number , without any significant change in the receptor affinity . |
| The treatment of human tonsillar T- cell_typelymphocytes with 4-phorbol 12-myristate 13-acetate ( PMA ), resulted in about two fold increase in glucocorticoid receptor ( GR ) number , without any significant change in the receptor affinity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6222 | 10.9185 | 1.0000 | Alone, PMA and calcium ionophore A23187 did not affect, but together stimulated, like proteinphytohaemagglutinin ( PHA ), leucine and, in particular, thymidine incorporation . |
| 0.9724 | 1.0000 | 1.0000 | Alone, PMA and calcium ionophore A23187 did not affect, but together stimulated, like phytohaemagglutinin ( proteinPHA ), leucine and, in particular, thymidine incorporation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5478 | 10.8205 | 1.0000 | PMA enhanced slightly the stimulatory effect of proteinPHA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9180 | 1.0000 | 1.0000 | Alone, these agents failed to alter the suppressive effect of dexamethasone on thymidine and leucine incorporation ; however, PMA -A23187 and PMA protein-PHA combinations appeared to antagonize the suppression by dexamethasone . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4107 | 10.1443 | 1.0000 | To be or not to be a responder in T-cell responses : proteinubiquitous oligopeptides in all proteins. |
| 0.7251 | 0.9999 | 1.0000 | To be or not to be a responder in cell_typeT-cell responses : ubiquitous oligopeptides in all proteins. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6098 | 10.1903 | 1.0000 | Amino acid sequences of all proteinproteins are essays written in the same language. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8876 | 1.0000 | 1.0000 | Accordingly, the same set of words and phrases ( oligopeptides ) appear in totally unrelated proteinproteins . |
| 0.8286 | 1.0000 | 1.0000 | Accordingly, the same set of words and phrases ( proteinoligopeptides ) appear in totally unrelated proteins . |
| Accordingly, the same set of words and phrases ( oligopeptides ) appear in totally proteinunrelated proteins . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6809 | 10.6959 | 1.0000 | The reason that only certain individuals of particular major histocompatibility complex (MHC) haplotypes can mount T-cell responses against a given antigen of pathogens is found in the fact that proteinT-cell receptors are designed to recognize 18-20 residue-long peptide fragments sandwiched between two alpha-helices of class I or class II MHC molecules . |
| 0.9150 | 1.0000 | 1.0000 | The reason that only certain individuals of particular major histocompatibility complex (MHC) haplotypes can mount T-cell responses against a given antigen of pathogens is found in the fact that T-cell receptors are designed to recognize 18-20 residue-long peptide fragments sandwiched between two proteinalpha-helices of class I or class II MHC molecules . |
| 3.6313 | 20.7671 | 10.7471 | The reason that only certain individuals of particular proteinmajor histocompatibility complex (MHC) haplotypes can mount T-cell responses against a given antigen of pathogens is found in the fact that T-cell receptors are designed to recognize 18-20 residue-long peptide fragments sandwiched between two alpha-helices of class I or class II MHC molecules . |
| The reason that only certain individuals of particular major histocompatibility complex (MHC) haplotypes can mount T-cell responses against a given antigen of pathogens is found in the fact that T-cell receptors are designed to recognize 18-20 residue-long peptide fragments sandwiched between two alpha-helices of proteinclass I or class II MHC molecules . | |||
| The reason that only certain individuals of particular major histocompatibility complex (MHC) haplotypes can mount T-cell responses against a given antigen of pathogens is found in the fact that T-cell receptors are designed to recognize 18-20 residue-long peptide fragments sandwiched between two alpha-helices of class I or proteinclass II MHC molecules . | |||
| The reason that only certain individuals of particular proteinmajor histocompatibility complex (MHC) haplotypes can mount T-cell responses against a given antigen of pathogens is found in the fact that T-cell receptors are designed to recognize 18-20 residue-long peptide fragments sandwiched between two alpha-helices of class I or class II MHC molecules . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3310 | 20.4092 | 1.0000 | Two distinct signal transmission pathways in cell_typeT lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin . |
| 1.6165 | 10.7080 | 1.0000 | Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an proteinimmunophilin and either FK506 or rapamycin . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4845 | 20.0972 | 1.0000 | Proliferation and immunologic function of T lymphocytes are initiated by signals from the proteinantigen receptor that are inhibited by the immunosuppressant FK506 but not by its structural analog, rapamycin . |
| 2.4581 | 20.2467 | 1.0000 | Proliferation and immunologic function of cell_typeT lymphocytes are initiated by signals from the antigen receptor that are inhibited by the immunosuppressant FK506 but not by its structural analog, rapamycin . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2953 | 20.6916 | 1.0000 | On the other hand, proteininterleukin 2 ( IL-2 )-induced signals are blocked by rapamycin but not by FK506 . |
| 0.9763 | 1.0000 | 1.0000 | On the other hand, interleukin 2 ( proteinIL-2 )-induced signals are blocked by rapamycin but not by FK506 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8803 | 20.8476 | 10.6262 | Remarkably, these two drugs inhibit each other's actions, raising the possibility that both act by means of a common immunophilin ( proteinimmunosuppressant binding protein ). |
| 0.8458 | 0.9997 | 1.0000 | Remarkably, these two drugs inhibit each other's actions, raising the possibility that both act by means of a common proteinimmunophilin ( immunosuppressant binding protein ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7450 | 30.0733 | 10.7545 | We find that the dissociation constant of rapamycin to the proteinFK506 binding protein FKBP (Kd = 0.2 nM) is close to the dissociation constant of FK506 to FKBP (Kd = 0.4 nM) and to their effective biologic inhibitory concentrations . |
| 1.6496 | 10.6870 | 1.0000 | We find that the dissociation constant of rapamycin to the FK506 binding protein FKBP (Kd = 0.2 nM) is close to the dissociation constant of FK506 to proteinFKBP (Kd = 0.4 nM) and to their effective biologic inhibitory concentrations . |
| 0.9755 | 1.0000 | 1.0000 | We find that the dissociation constant of rapamycin to the FK506 binding protein proteinFKBP (Kd = 0.2 nM) is close to the dissociation constant of FK506 to FKBP (Kd = 0.4 nM) and to their effective biologic inhibitory concentrations . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8949 | 20.2400 | 10.4106 | However, an excess of rapamycin is needed to revert FK506 -mediated inhibition of IL-2 production , apoptosis , and transcriptional activation of NF-AT , a proteinT-cell-specific transcription factor necessary for IL-2 gene activation . |
| 2.0983 | 20.3563 | 0.9894 | However, an excess of rapamycin is needed to revert FK506 -mediated inhibition of IL-2 production , apoptosis , and transcriptional activation of NF-AT , a T-cell-specific transcription factor necessary for proteinIL-2 gene activation . |
| 2.0889 | 20.4004 | 0.9998 | However, an excess of rapamycin is needed to revert FK506 -mediated inhibition of IL-2 production , apoptosis , and transcriptional activation of NF-AT , a T-cell-specific transcription factor necessary for DNAIL-2 gene activation . |
| 1.6644 | 10.2385 | 1.0000 | However, an excess of rapamycin is needed to revert FK506 -mediated inhibition of IL-2 production , apoptosis , and transcriptional activation of proteinNF-AT , a T-cell-specific transcription factor necessary for IL-2 gene activation . |
| 1.6103 | 10.2099 | 1.0000 | However, an excess of rapamycin is needed to revert FK506 -mediated inhibition of proteinIL-2 production , apoptosis , and transcriptional activation of NF-AT , a T-cell-specific transcription factor necessary for IL-2 gene activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7475 | 10.1391 | 1.0000 | Similarly, an excess of FK506 is needed to revert rapamycin -mediated inhibition of proteinIL-2 -induced proliferation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4318 | 20.5340 | 1.0000 | The drug concentrations required for antagonism may be explained by the relative affinity of the drugs to, and by the abundance of, the proteinimmunophilin FKBP . |
| The drug concentrations required for antagonism may be explained by the relative affinity of the drugs to, and by the abundance of, the immunophilin proteinFKBP . | |||
| The drug concentrations required for antagonism may be explained by the relative affinity of the drugs to, and by the abundance of, the proteinimmunophilin FKBP . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7735 | 10.6130 | 1.0000 | FKBP has been shown to catalyze the interconversion of the cis- and trans- rotamers of the peptidyl-prolyl amide bond of peptide substrates ; here we show that rapamycin , like FK506 , is a potent inhibitor of the rotamase activity of proteinFKBP (Ki = 0.2 nM). |
| 0.9880 | 1.0000 | 1.0000 | proteinFKBP has been shown to catalyze the interconversion of the cis- and trans- rotamers of the peptidyl-prolyl amide bond of peptide substrates ; here we show that rapamycin , like FK506 , is a potent inhibitor of the rotamase activity of FKBP (Ki = 0.2 nM). |
| 0.8992 | 0.9999 | 1.0000 | FKBP has been shown to catalyze the interconversion of the cis- and trans- rotamers of the peptidyl-prolyl amide bond of peptide substrates ; here we show that rapamycin , like FK506 , is a potent inhibitor of the proteinrotamase activity of FKBP (Ki = 0.2 nM). |
| FKBP has been shown to catalyze the interconversion of the cis- and trans- rotamers of the proteinpeptidyl-prolyl amide bond of peptide substrates ; here we show that rapamycin , like FK506 , is a potent inhibitor of the rotamase activity of FKBP (Ki = 0.2 nM). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9463 | 1.0000 | 1.0000 | Neither proteinFKBP binding nor inhibition of rotamase activity of FKBP alone is sufficient to explain the biologic actions of these drugs. |
| 0.8993 | 1.0000 | 1.0000 | Neither FKBP binding nor inhibition of rotamase activity of proteinFKBP alone is sufficient to explain the biologic actions of these drugs. |
| 0.8186 | 1.0000 | 1.0000 | Neither FKBP binding nor inhibition of proteinrotamase activity of FKBP alone is sufficient to explain the biologic actions of these drugs. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6915 | 10.3165 | 1.0000 | Rather, these findings suggest that proteinimmunophilin bound to FK506 interferes with antigen receptor -induced signals , while rapamycin bound to the immunophilin interferes with IL-2 -induced signals . |
| 1.6815 | 10.2855 | 1.0000 | Rather, these findings suggest that immunophilin bound to FK506 interferes with antigen receptor -induced signals , while rapamycin bound to the proteinimmunophilin interferes with IL-2 -induced signals . |
| 1.6110 | 10.5649 | 1.0000 | Rather, these findings suggest that immunophilin bound to FK506 interferes with proteinantigen receptor -induced signals , while rapamycin bound to the immunophilin interferes with IL-2 -induced signals . |
| 0.8973 | 1.0000 | 1.0000 | Rather, these findings suggest that immunophilin bound to FK506 interferes with antigen receptor -induced signals , while rapamycin bound to the immunophilin interferes with proteinIL-2 -induced signals . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5496 | 20.3232 | 10.6963 | Adherence-dependent increase in RNAhuman monocyte PDGF(B) mRNA is associated with increases in c-fos , c-jun , and EGR2 mRNA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2483 | 20.6269 | 0.9993 | Adherence is an important initial step in the transition of a circulating monocyte to a cell_typetissue macrophage . |
| 2.1709 | 20.9283 | 0.9999 | Adherence is an important initial step in the transition of a cell_typecirculating monocyte to a tissue macrophage . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5782 | 10.7172 | 1.0000 | This differentiation is accompanied by an augmented capacity to generate proteingrowth factors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.6306 | 30.0021 | 10.7297 | We hypothesized that adherence itself might be an important trigger for a sequence of gene activation culminating in cells with increased mRNA encoding profibrotic growth factors such as proteinplatelet-derived growth factor B subunit ( PDGF[B] ) and transforming growth factor-beta ( TGF-beta ). |
| 3.5415 | 20.9986 | 10.7835 | We hypothesized that adherence itself might be an important trigger for a sequence of gene activation culminating in cells with increased mRNA encoding profibrotic growth factors such as platelet-derived growth factor B subunit ( PDGF[B] ) and proteintransforming growth factor-beta ( TGF-beta ). |
| 1.6626 | 10.7205 | 1.0000 | We hypothesized that adherence itself might be an important trigger for a sequence of gene activation culminating in cells with increased RNAmRNA encoding profibrotic growth factors such as platelet-derived growth factor B subunit ( PDGF[B] ) and transforming growth factor-beta ( TGF-beta ). |
| 0.9547 | 1.0000 | 1.0000 | We hypothesized that adherence itself might be an important trigger for a sequence of gene activation culminating in cells with increased mRNA encoding profibrotic growth factors such as platelet-derived growth factor B subunit ( PDGF[B] ) and transforming growth factor-beta ( proteinTGF-beta ). |
| 0.7742 | 1.0000 | 1.0000 | We hypothesized that adherence itself might be an important trigger for a sequence of gene activation culminating in cells with increased mRNA encoding profibrotic growth factors such as platelet-derived growth factor B subunit ( proteinPDGF[B] ) and transforming growth factor-beta ( TGF-beta ). |
| 2.1929 | 10.8162 | 10.3783 | We hypothesized that adherence itself might be an important trigger for a sequence of gene activation culminating in cells with increased mRNA encoding proteinprofibrotic growth factors such as platelet-derived growth factor B subunit ( PDGF[B] ) and transforming growth factor-beta ( TGF-beta ). |
| We hypothesized that adherence itself might be an important trigger for a sequence of gene activation culminating in cells with increased mRNA encoding profibrotic proteingrowth factors such as platelet-derived growth factor B subunit ( PDGF[B] ) and transforming growth factor-beta ( TGF-beta ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7899 | 10.9652 | 1.0000 | After in vitro adherence, human monocytes had a biphasic increase in RNAPDGF(B) mRNA with peaks at 6 h and 13 d. |
| 1.3754 | 10.8893 | 0.9930 | After in vitro adherence, human monocytes had a biphasic increase in proteinPDGF(B) mRNA with peaks at 6 h and 13 d. |
| 1.5810 | 10.8389 | 0.9999 | After in vitro adherence, cell_typehuman monocytes had a biphasic increase in PDGF(B) mRNA with peaks at 6 h and 13 d. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7119 | 10.1964 | 1.0000 | No increase in RNATGF-beta mRNA was observed. |
| 1.2753 | 10.1340 | 0.9946 | No increase in proteinTGF-beta mRNA was observed. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6767 | 20.2137 | 1.0000 | The 6-h increase in RNAPDGF(B) mRNA was adherence dependent, and in addition, was abrogated when the cytoskeletal integrity was compromised by cytochalasin D . |
| 2.3108 | 20.3890 | 0.9955 | The 6-h increase in proteinPDGF(B) mRNA was adherence dependent, and in addition, was abrogated when the cytoskeletal integrity was compromised by cytochalasin D . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6604 | 20.0287 | 1.0000 | The 6-h increase in RNAPDGF(B) mRNA was unaltered by adherence in the presence of the monocyte stimulus lipopolysaccharide . |
| 2.1823 | 20.1433 | 0.9952 | The 6-h increase in proteinPDGF(B) mRNA was unaltered by adherence in the presence of the monocyte stimulus lipopolysaccharide . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5729 | 20.4463 | 1.0000 | Adherence to either fibronectin or collagen-coated plastic had little consistent effect on RNAPDGF(B) mRNA accumulation . |
| 1.9814 | 20.3677 | 0.9885 | Adherence to either fibronectin or collagen-coated plastic had little consistent effect on proteinPDGF(B) mRNA accumulation . |
| 1.5783 | 10.5642 | 1.0000 | Adherence to either proteinfibronectin or collagen-coated plastic had little consistent effect on PDGF(B) mRNA accumulation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5132 | 20.5569 | 10.9786 | The increased PDGF(B) mRNA observed in adherent monocytes was accompanied by increases in mRNAs of the DNAearly growth response genes c-fos (maximal at 20 min), c-jun, and EGR2 (maximal at 6-24 h). |
| 2.3664 | 20.3284 | 1.0000 | The increased RNAPDGF(B) mRNA observed in adherent monocytes was accompanied by increases in mRNAs of the early growth response genes c-fos (maximal at 20 min), c-jun, and EGR2 (maximal at 6-24 h). |
| 1.7350 | 20.4372 | 0.9858 | The increased proteinPDGF(B) mRNA observed in adherent monocytes was accompanied by increases in mRNAs of the early growth response genes c-fos (maximal at 20 min), c-jun, and EGR2 (maximal at 6-24 h). |
| 1.6775 | 10.6669 | 1.0000 | The increased PDGF(B) mRNA observed in adherent monocytes was accompanied by increases in RNAmRNAs of the early growth response genes c-fos (maximal at 20 min), c-jun, and EGR2 (maximal at 6-24 h). |
| 1.2678 | 10.4672 | 0.9999 | The increased PDGF(B) mRNA observed in cell_typeadherent monocytes was accompanied by increases in mRNAs of the early growth response genes c-fos (maximal at 20 min), c-jun, and EGR2 (maximal at 6-24 h). |
| 0.9482 | 1.0000 | 1.0000 | The increased PDGF(B) mRNA observed in adherent monocytes was accompanied by increases in mRNAs of the early growth response genes DNAc-fos (maximal at 20 min), c-jun, and EGR2 (maximal at 6-24 h). |
| 0.9099 | 1.0000 | 1.0000 | The increased PDGF(B) mRNA observed in adherent monocytes was accompanied by increases in mRNAs of the early growth response genes c-fos (maximal at 20 min), c-jun, and DNAEGR2 (maximal at 6-24 h). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4791 | 10.3918 | 0.9998 | The increase in c-jun and EGR2, but not DNAc-fos , mRNA was also abrogated by cytochalasin D . |
| 1.1828 | 10.2956 | 0.9998 | The increase in c-jun and EGR2, but not RNAc-fos , mRNA was also abrogated by cytochalasin D . |
| 0.5328 | 1.0000 | 0.9999 | The increase in DNAc-jun and EGR2, but not c-fos , mRNA was also abrogated by cytochalasin D . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6066 | 10.4936 | 0.9998 | These observations suggest that adherence results in increases of c-fos , c-jun , EGR2 , and RNAPDGF(B) mRNA . |
| 1.0542 | 10.2047 | 1.0000 | These observations suggest that adherence results in increases of RNAc-fos , c-jun , EGR2 , and PDGF(B) mRNA . |
| 0.7476 | 1.0000 | 1.0000 | These observations suggest that adherence results in increases of c-fos , c-jun , proteinEGR2 , and PDGF(B) mRNA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6442 | 10.6969 | 1.0000 | In addition, the increases in c-jun , EGR2 , and proteinPDGF(B) may depend on cytoskeletal rearrangement . |
| 1.3837 | 10.6458 | 1.0000 | In addition, the increases in DNAc-jun , EGR2 , and PDGF(B) may depend on cytoskeletal rearrangement . |
| 0.9030 | 1.0000 | 1.0000 | In addition, the increases in c-jun , proteinEGR2 , and PDGF(B) may depend on cytoskeletal rearrangement . |
| In addition, the increases in c-jun , DNAEGR2 , and PDGF(B) may depend on cytoskeletal rearrangement . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7571 | 20.8481 | 10.2515 | Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the proteinT-cell antigen receptor . |
| 2.2485 | 20.7155 | 1.0000 | Single cell assay of a proteintranscription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2219 | 20.4764 | 1.0000 | Stimulation of T lymphocytes through their antigen receptor leads to the appearance of several proteintranscription factors , including NF-AT and NF-kappa B , which are involved in regulating genes required for immunologic activation. |
| 2.1676 | 20.1948 | 1.0000 | Stimulation of T lymphocytes through their proteinantigen receptor leads to the appearance of several transcription factors , including NF-AT and NF-kappa B , which are involved in regulating genes required for immunologic activation. |
| 2.1428 | 20.5654 | 0.9999 | Stimulation of cell_typeT lymphocytes through their antigen receptor leads to the appearance of several transcription factors , including NF-AT and NF-kappa B , which are involved in regulating genes required for immunologic activation. |
| 1.7411 | 10.3423 | 1.0000 | Stimulation of T lymphocytes through their antigen receptor leads to the appearance of several transcription factors , including proteinNF-AT and NF-kappa B , which are involved in regulating genes required for immunologic activation. |
| 1.5869 | 10.6612 | 1.0000 | Stimulation of T lymphocytes through their antigen receptor leads to the appearance of several transcription factors , including NF-AT and proteinNF-kappa B , which are involved in regulating genes required for immunologic activation. |
| 2.1800 | 20.7819 | 1.0000 | Stimulation of T lymphocytes through their antigen receptor leads to the appearance of several transcription factors , including NF-AT and NF-kappa B , which are involved in DNAregulating genes required for immunologic activation. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6996 | 10.4535 | 1.0000 | To investigate the activity of a single transcription factor in individual viable cells , we have applied an assay that uses the fluorescence-activated cell sorter to quantitate proteinbeta-galactosidase ( beta-gal ). |
| 1.5856 | 10.8586 | 1.0000 | To investigate the activity of a single proteintranscription factor in individual viable cells , we have applied an assay that uses the fluorescence-activated cell sorter to quantitate beta-galactosidase ( beta-gal ). |
| 0.9658 | 1.0000 | 1.0000 | To investigate the activity of a single transcription factor in individual viable cells , we have applied an assay that uses the fluorescence-activated cell sorter to quantitate beta-galactosidase ( proteinbeta-gal ). |
| To investigate the activity of a single transcription factor in cell_typeindividual viable cells , we have applied an assay that uses the fluorescence-activated cell sorter to quantitate beta-galactosidase ( beta-gal ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1553 | 30.1074 | 10.7825 | We have analyzed the distribution of NF-AT transcriptional activity among T cells undergoing activation by using a construct in which three tandem copies of the DNANF-AT -binding site directs transcription of the lacZ gene . |
| 2.2793 | 20.8444 | 0.9999 | We have analyzed the distribution of NF-AT transcriptional activity among cell_typeT cells undergoing activation by using a construct in which three tandem copies of the NF-AT -binding site directs transcription of the lacZ gene . |
| 2.2184 | 20.3718 | 0.9981 | We have analyzed the distribution of NF-AT transcriptional activity among T cells undergoing activation by using a construct in which three tandem copies of the proteinNF-AT -binding site directs transcription of the lacZ gene . |
| 2.1816 | 20.5223 | 0.9999 | We have analyzed the distribution of NF-AT transcriptional activity among T cells undergoing activation by using a construct in which three tandem copies of the NF-AT -binding site directs transcription of the DNAlacZ gene . |
| 1.5847 | 10.8117 | 1.0000 | We have analyzed the distribution of proteinNF-AT transcriptional activity among T cells undergoing activation by using a construct in which three tandem copies of the NF-AT -binding site directs transcription of the lacZ gene . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7083 | 10.3799 | 1.0000 | Unexpectedly, stimulation of cloned stably transfected Jurkat T cells leads to a bimodal pattern of beta-gal expression in which some cells express no proteinbeta-gal and others express high levels. |
| 0.7538 | 0.9996 | 0.9987 | Unexpectedly, stimulation of cloned stably transfected Jurkat cell_typeT cells leads to a bimodal pattern of beta-gal expression in which some cells express no beta-gal and others express high levels. |
| 2.9863 | 10.8558 | 10.9475 | Unexpectedly, stimulation of cloned stably transfected cell_lineJurkat T cells leads to a bimodal pattern of beta-gal expression in which some cells express no beta-gal and others express high levels. |
| 0.8885 | 1.0000 | 1.0000 | Unexpectedly, stimulation of cloned stably transfected Jurkat T cells leads to a bimodal pattern of proteinbeta-gal expression in which some cells express no beta-gal and others express high levels. |
| Unexpectedly, stimulation of cell_linecloned stably transfected Jurkat T cells leads to a bimodal pattern of beta-gal expression in which some cells express no beta-gal and others express high levels. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7382 | 10.3658 | 1.0000 | Further results, in which beta-gal activity is correlated with NF-AT -binding activity , indicate that the concentration of proteinNF-AT must exceed a critical threshold before transcription initiates. |
| 0.9374 | 1.0000 | 1.0000 | Further results, in which proteinbeta-gal activity is correlated with NF-AT -binding activity , indicate that the concentration of NF-AT must exceed a critical threshold before transcription initiates. |
| 0.9143 | 1.0000 | 1.0000 | Further results, in which beta-gal activity is correlated with proteinNF-AT -binding activity , indicate that the concentration of NF-AT must exceed a critical threshold before transcription initiates. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7550 | 10.2657 | 1.0000 | This threshold likely reflects the NF-AT concentration-dependent assembly of transcription complexes at the DNApromoter . |
| 1.5295 | 10.9844 | 1.0000 | This threshold likely reflects the NF-AT concentration-dependent assembly of proteintranscription complexes at the promoter . |
| 0.9073 | 1.0000 | 1.0000 | This threshold likely reflects the proteinNF-AT concentration-dependent assembly of transcription complexes at the promoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3997 | 20.0983 | 1.0000 | Similar constructs controlled by proteinNF-kappa B or the entire interleukin-2 enhancer show bimodal expression patterns during induction, suggesting that thresholds set by the concentration of transcription factors may be a common property of inducible genes . |
| 2.3513 | 20.3182 | 1.0000 | Similar constructs controlled by NF-kappa B or the entire DNAinterleukin-2 enhancer show bimodal expression patterns during induction, suggesting that thresholds set by the concentration of transcription factors may be a common property of inducible genes . |
| 2.3270 | 20.5643 | 0.9999 | Similar constructs controlled by NF-kappa B or the entire interleukin-2 enhancer show bimodal expression patterns during induction, suggesting that thresholds set by the concentration of transcription factors may be a common property of DNAinducible genes . |
| 2.2899 | 20.4464 | 1.0000 | Similar constructs controlled by NF-kappa B or the entire interleukin-2 enhancer show bimodal expression patterns during induction, suggesting that thresholds set by the concentration of proteintranscription factors may be a common property of inducible genes . |
| 2.2430 | 20.1752 | 0.9905 | Similar constructs controlled by NF-kappa B or the entire proteininterleukin-2 enhancer show bimodal expression patterns during induction, suggesting that thresholds set by the concentration of transcription factors may be a common property of inducible genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3841 | 10.1196 | 30.1127 | The DNAEpstein-Barr virus ( EBV ) BMRF1 promoter for early antigen ( EA-D ) is regulated by the EBV transactivators , BRLF1 and BZLF1 , in a cell-specific manner . |
| 1.5488 | 10.7597 | 0.9999 | The Epstein-Barr virus ( EBV ) BMRF1 promoter for proteinearly antigen ( EA-D ) is regulated by the EBV transactivators , BRLF1 and BZLF1 , in a cell-specific manner . |
| 1.2658 | 20.6257 | 1.0000 | The Epstein-Barr virus ( EBV ) BMRF1 promoter for early antigen ( EA-D ) is regulated by the proteinEBV transactivators , BRLF1 and BZLF1 , in a cell-specific manner . |
| 0.9696 | 1.0000 | 1.0000 | The Epstein-Barr virus ( EBV ) BMRF1 promoter for early antigen ( proteinEA-D ) is regulated by the EBV transactivators , BRLF1 and BZLF1 , in a cell-specific manner . |
| 0.9624 | 1.0000 | 1.0000 | The Epstein-Barr virus ( EBV ) BMRF1 promoter for early antigen ( EA-D ) is regulated by the EBV transactivators , BRLF1 and proteinBZLF1 , in a cell-specific manner . |
| 0.9319 | 1.0000 | 1.0000 | The Epstein-Barr virus ( EBV ) BMRF1 promoter for early antigen ( EA-D ) is regulated by the EBV transactivators , proteinBRLF1 and BZLF1 , in a cell-specific manner . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0299 | 10.1848 | 20.0972 | The proteinEpstein-Barr virus early antigen diffuse component ( EA-D ) is essential for Epstein-Barr virus DNA polymerase activity , and its activity is suppressed during latent infection. |
| 0.9567 | 1.0000 | 1.0000 | The Epstein-Barr virus early antigen diffuse component ( proteinEA-D ) is essential for Epstein-Barr virus DNA polymerase activity , and its activity is suppressed during latent infection. |
| 3.3634 | 30.2429 | 10.6559 | The Epstein-Barr virus early antigen diffuse component ( EA-D ) is essential for proteinEpstein-Barr virus DNA polymerase activity , and its activity is suppressed during latent infection. |
| The Epstein-Barr virus early antigen diffuse component ( EA-D ) is essential for Epstein-Barr DNAvirus DNA polymerase activity , and its activity is suppressed during latent infection. | |||
| The Epstein-Barr virus proteinearly antigen diffuse component ( EA-D ) is essential for Epstein-Barr virus DNA polymerase activity , and its activity is suppressed during latent infection. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2717 | 20.9927 | 10.6313 | We investigated the regulation of the promoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two proteinimmediate-early viral transactivators , BZLF1 ( Z ) and BRLF1 ( R ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| 2.0946 | 20.2764 | 0.9998 | We investigated the regulation of the promoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , BZLF1 ( Z ) and BRLF1 ( R ), focusing on the differences in response in cell_typelymphoid cells and epithelial cells . |
| 1.8000 | 10.1806 | 0.9999 | We investigated the regulation of the promoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , BZLF1 ( Z ) and proteinBRLF1 ( R ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| 1.6686 | 10.1996 | 1.0000 | We investigated the regulation of the DNApromoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , BZLF1 ( Z ) and BRLF1 ( R ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| 1.5385 | 10.8854 | 0.9995 | We investigated the regulation of the promoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , BZLF1 ( Z ) and BRLF1 ( R ), focusing on the differences in response in lymphoid cells and cell_typeepithelial cells . |
| 0.9506 | 1.0000 | 1.0000 | We investigated the regulation of the promoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , BZLF1 ( proteinZ ) and BRLF1 ( R ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| 0.9492 | 1.0000 | 1.0000 | We investigated the regulation of the promoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , BZLF1 ( Z ) and BRLF1 ( proteinR ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| 0.9397 | 1.0000 | 1.0000 | We investigated the regulation of the promoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , proteinBZLF1 ( Z ) and BRLF1 ( R ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| 0.9196 | 1.0000 | 1.0000 | We investigated the regulation of the promoter ( DNABMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , BZLF1 ( Z ) and BRLF1 ( R ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| 2.0316 | 20.7221 | 1.0000 | We investigated the regulation of the promoter ( BMRF1 ) for this DNAearly gene by studying its responsiveness in vitro to two immediate-early viral transactivators , BZLF1 ( Z ) and BRLF1 ( R ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| 1.2958 | 10.6972 | 0.9998 | We investigated the regulation of the promoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , BZLF1 ( Z ) and proteinBRLF1 ( R ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| 1.1864 | 10.3820 | 0.9985 | We investigated the regulation of the promoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , proteinBZLF1 ( Z ) and BRLF1 ( R ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| 0.5034 | 0.9926 | 1.0000 | We investigated the regulation of the promoter ( BMRF1 ) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators , proteinBZLF1 ( Z ) and BRLF1 ( R ), focusing on the differences in response in lymphoid cells and epithelial cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4336 | 20.8675 | 1.0000 | In lymphoid cells , Z or R alone produced only small increases in DNAEA-D promoter activity , whereas both transactivators together produced a large stimulatory effect. |
| 1.6422 | 10.2017 | 1.0000 | In lymphoid cells , Z or R alone produced only small increases in EA-D promoter activity , whereas both proteintransactivators together produced a large stimulatory effect. |
| 1.6083 | 10.7390 | 0.9998 | In cell_typelymphoid cells , Z or R alone produced only small increases in EA-D promoter activity , whereas both transactivators together produced a large stimulatory effect. |
| 0.9528 | 1.0000 | 1.0000 | In lymphoid cells , Z or proteinR alone produced only small increases in EA-D promoter activity , whereas both transactivators together produced a large stimulatory effect. |
| 0.9509 | 1.0000 | 1.0000 | In lymphoid cells , proteinZ or R alone produced only small increases in EA-D promoter activity , whereas both transactivators together produced a large stimulatory effect. |
| In lymphoid cells , Z or R alone produced only small increases in proteinEA-D promoter activity , whereas both transactivators together produced a large stimulatory effect. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2227 | 20.5479 | 1.0000 | In epithelial cells , the Z transactivator alone produced maximal stimulation of the DNAEA-D promoter ; the effect of R and Z together was no greater than that of Z alone. |
| 2.2173 | 20.8333 | 1.0000 | In epithelial cells , the Z transactivator alone produced maximal stimulation of the EA-D promoter ; the effect of R and Z together was no greater than that of proteinZ alone. |
| 1.5936 | 10.6317 | 0.9998 | In cell_typeepithelial cells , the Z transactivator alone produced maximal stimulation of the EA-D promoter ; the effect of R and Z together was no greater than that of Z alone. |
| 1.4217 | 20.9014 | 0.9999 | In epithelial cells , the proteinZ transactivator alone produced maximal stimulation of the EA-D promoter ; the effect of R and Z together was no greater than that of Z alone. |
| 0.9421 | 1.0000 | 1.0000 | In epithelial cells , the Z transactivator alone produced maximal stimulation of the EA-D promoter ; the effect of R and proteinZ together was no greater than that of Z alone. |
| 0.8709 | 1.0000 | 1.0000 | In epithelial cells , the Z transactivator alone produced maximal stimulation of the EA-D promoter ; the effect of proteinR and Z together was no greater than that of Z alone. |
| In epithelial cells , the Z transactivator alone produced maximal stimulation of the proteinEA-D promoter ; the effect of R and Z together was no greater than that of Z alone. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9483 | 20.1283 | 10.8938 | Deletional analysis and site-directed mutagenesis of the EA-D promoter demonstrated that in epithelial cells the potential DNAAP-1 binding site plays an essential role in Z responsiveness, although sequences further upstream are also important. |
| 2.2374 | 20.1238 | 1.0000 | Deletional analysis and site-directed mutagenesis of the DNAEA-D promoter demonstrated that in epithelial cells the potential AP-1 binding site plays an essential role in Z responsiveness, although sequences further upstream are also important. |
| 1.5394 | 10.9609 | 0.9999 | Deletional analysis and site-directed mutagenesis of the EA-D promoter demonstrated that in cell_typeepithelial cells the potential AP-1 binding site plays an essential role in Z responsiveness, although sequences further upstream are also important. |
| 0.9277 | 1.0000 | 1.0000 | Deletional analysis and site-directed mutagenesis of the EA-D promoter demonstrated that in epithelial cells the potential AP-1 binding site plays an essential role in proteinZ responsiveness, although sequences further upstream are also important. |
| 1.3998 | 10.5054 | 0.9962 | Deletional analysis and site-directed mutagenesis of the EA-D promoter demonstrated that in epithelial cells the potential proteinAP-1 binding site plays an essential role in Z responsiveness, although sequences further upstream are also important. |
| Deletional analysis and site-directed mutagenesis of the proteinEA-D promoter demonstrated that in epithelial cells the potential AP-1 binding site plays an essential role in Z responsiveness, although sequences further upstream are also important. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2066 | 20.1719 | 0.9999 | In lymphoid cells , only the DNAupstream sequences are required for transactivation by the Z/R combination, and the AP-1 site is dispensable. |
| 1.6442 | 10.7976 | 0.9999 | In cell_typelymphoid cells , only the upstream sequences are required for transactivation by the Z/R combination, and the AP-1 site is dispensable. |
| 2.1956 | 20.2897 | 1.0000 | In lymphoid cells , only the upstream sequences are required for transactivation by the Z/R combination, and the DNAAP-1 site is dispensable. |
| 2.1162 | 20.1608 | 0.9884 | In lymphoid cells , only the upstream sequences are required for transactivation by the Z/R combination, and the proteinAP-1 site is dispensable. |
| In lymphoid cells , only the upstream sequences are required for transactivation by the Z/R combination, and the proteinAP-1 site is dispensable. | |||
| In lymphoid cells , only the upstream sequences are required for transactivation by the proteinZ/R combination, and the AP-1 site is dispensable. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3428 | 30.8860 | 10.7619 | These data suggest that DNAEA-D ( BMRF1 ) promoter regulation by Z and R is cell type specific and appears to involve different mechanisms in each cell type. |
| 0.7664 | 1.0000 | 0.9945 | These data suggest that EA-D ( proteinBMRF1 ) promoter regulation by Z and R is cell type specific and appears to involve different mechanisms in each cell type. |
| These data suggest that EA-D ( BMRF1 ) promoter regulation by Z and proteinR is cell type specific and appears to involve different mechanisms in each cell type. | |||
| These data suggest that EA-D ( DNABMRF1 ) promoter regulation by Z and R is cell type specific and appears to involve different mechanisms in each cell type. | |||
| These data suggest that proteinEA-D ( BMRF1 ) promoter regulation by Z and R is cell type specific and appears to involve different mechanisms in each cell type. | |||
| These data suggest that EA-D ( BMRF1 ) promoter regulation by proteinZ and R is cell type specific and appears to involve different mechanisms in each cell type. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.8018 | 30.8944 | 20.5948 | Complementary DNA encoding the proteinhuman T-cell FK506 -binding protein , a peptidylprolyl cis-trans isomerase distinct from cyclophilin . |
| 3.9280 | 30.8778 | 10.8157 | Complementary DNA encoding the human T-cell FK506 -binding protein , a proteinpeptidylprolyl cis-trans isomerase distinct from cyclophilin . |
| 1.8916 | 20.1320 | 1.0000 | Complementary DNA encoding the human T-cell FK506 -binding protein , a peptidylprolyl cis-trans isomerase distinct from proteincyclophilin . |
| 0.7334 | 0.9982 | 0.9998 | DNAComplementary DNA encoding the human T-cell FK506 -binding protein , a peptidylprolyl cis-trans isomerase distinct from cyclophilin . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4941 | 20.7618 | 10.8462 | After the recent discovery that the cyclosporin A -binding protein cyclophilin is identical to peptidylprolyl cis-trans isomerase , a proteincellular binding protein for FK506 was found to be distinct from cyclophilin but to have the same enzymatic activity . |
| 3.1147 | 30.7224 | 0.9992 | After the recent discovery that the proteincyclosporin A -binding protein cyclophilin is identical to peptidylprolyl cis-trans isomerase , a cellular binding protein for FK506 was found to be distinct from cyclophilin but to have the same enzymatic activity . |
| 2.9328 | 20.8642 | 10.2168 | After the recent discovery that the cyclosporin A -binding protein cyclophilin is identical to proteinpeptidylprolyl cis-trans isomerase , a cellular binding protein for FK506 was found to be distinct from cyclophilin but to have the same enzymatic activity . |
| 1.5106 | 10.7764 | 1.0000 | After the recent discovery that the cyclosporin A -binding protein cyclophilin is identical to peptidylprolyl cis-trans isomerase , a cellular binding protein for FK506 was found to be distinct from proteincyclophilin but to have the same enzymatic activity . |
| 0.9680 | 0.9999 | 1.0000 | After the recent discovery that the cyclosporin A -binding protein proteincyclophilin is identical to peptidylprolyl cis-trans isomerase , a cellular binding protein for FK506 was found to be distinct from cyclophilin but to have the same enzymatic activity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8233 | 20.7991 | 0.9999 | In this study, we isolated a cDNA coding for FK506 -binding protein ( FKBP ) from human peripheral blood T cells by using mixed 20-mer oligonucleotide probes synthesized on the basis of the sequence, Glu-Asp-Gly-Lys-Lys-Phe-Asp , reported for proteinbovine FKBP . |
| 1.4358 | 10.4158 | 1.0000 | In this study, we isolated a DNAcDNA coding for FK506 -binding protein ( FKBP ) from human peripheral blood T cells by using mixed 20-mer oligonucleotide probes synthesized on the basis of the sequence, Glu-Asp-Gly-Lys-Lys-Phe-Asp , reported for bovine FKBP . |
| 0.9588 | 1.0000 | 1.0000 | In this study, we isolated a cDNA coding for FK506 -binding protein ( proteinFKBP ) from human peripheral blood T cells by using mixed 20-mer oligonucleotide probes synthesized on the basis of the sequence, Glu-Asp-Gly-Lys-Lys-Phe-Asp , reported for bovine FKBP . |
| 0.9167 | 1.0000 | 1.0000 | In this study, we isolated a cDNA coding for FK506 -binding protein ( FKBP ) from human peripheral blood T cells by using mixed 20-mer oligonucleotide probes synthesized on the basis of the sequence, Glu-Asp-Gly-Lys-Lys-Phe-Asp , reported for bovine proteinFKBP . |
| 4.8238 | 20.9625 | 10.9867 | In this study, we isolated a cDNA coding for FK506 -binding protein ( FKBP ) from cell_typehuman peripheral blood T cells by using mixed 20-mer oligonucleotide probes synthesized on the basis of the sequence, Glu-Asp-Gly-Lys-Lys-Phe-Asp , reported for bovine FKBP . |
| 4.2191 | 20.8993 | 10.7708 | In this study, we isolated a cDNA coding for proteinFK506 -binding protein ( FKBP ) from human peripheral blood T cells by using mixed 20-mer oligonucleotide probes synthesized on the basis of the sequence, Glu-Asp-Gly-Lys-Lys-Phe-Asp , reported for bovine FKBP . |
| 2.5806 | 20.2974 | 10.0503 | In this study, we isolated a cDNA coding for FK506 -binding protein ( FKBP ) from human peripheral blood T cells by using mixed DNA20-mer oligonucleotide probes synthesized on the basis of the sequence, Glu-Asp-Gly-Lys-Lys-Phe-Asp , reported for bovine FKBP . |
| In this study, we isolated a cDNA coding for FK506 -binding protein ( FKBP ) from human peripheral blood cell_typeT cells by using mixed 20-mer oligonucleotide probes synthesized on the basis of the sequence, Glu-Asp-Gly-Lys-Lys-Phe-Asp , reported for bovine FKBP . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9458 | 10.9819 | 10.9784 | The DNA isolated contained an open reading frame encoding protein108 amino acid residues . |
| 2.7606 | 10.7715 | 10.9432 | The DNA isolated contained an DNAopen reading frame encoding 108 amino acid residues . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4971 | 20.9679 | 10.5308 | The first 40 residues of the deduced proteinamino acid sequence were identical to those of the reported amino-terminal sequence of bovine FKBP , indicating that the DNA sequence isolated represents the gene coding for FKBP . |
| 1.7097 | 10.6121 | 1.0000 | The first 40 residues of the deduced amino acid sequence were identical to those of the reported amino-terminal sequence of bovine FKBP , indicating that the DNA sequence isolated represents the gene coding for proteinFKBP . |
| 0.9743 | 1.0000 | 1.0000 | The first 40 residues of the deduced amino acid sequence were identical to those of the reported amino-terminal sequence of bovine proteinFKBP , indicating that the DNA sequence isolated represents the gene coding for FKBP . |
| 2.2642 | 20.5161 | 1.0000 | The first 40 residues of the deduced amino acid sequence were identical to those of the reported proteinamino-terminal sequence of bovine FKBP , indicating that the DNA sequence isolated represents the gene coding for FKBP . |
| 1.4590 | 10.8283 | 0.9999 | The first 40 residues of the deduced amino acid sequence were identical to those of the reported amino-terminal sequence of proteinbovine FKBP , indicating that the DNA sequence isolated represents the gene coding for FKBP . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6321 | 10.3260 | 1.0000 | Computer-assisted analysis of the deduced amino acid sequence indicates that FKBP exhibits no internal homology and does not have significant sequence similarity to any other amino acid sequences of known proteins, including proteincyclophilin . |
| 1.6238 | 10.4440 | 1.0000 | Computer-assisted analysis of the deduced amino acid sequence indicates that proteinFKBP exhibits no internal homology and does not have significant sequence similarity to any other amino acid sequences of known proteins, including cyclophilin . |
| 3.8177 | 20.4776 | 10.7186 | Computer-assisted analysis of the deduced proteinamino acid sequence indicates that FKBP exhibits no internal homology and does not have significant sequence similarity to any other amino acid sequences of known proteins, including cyclophilin . |
| 3.7711 | 20.6907 | 10.8478 | Computer-assisted analysis of the deduced amino acid sequence indicates that FKBP exhibits no internal homology and does not have significant sequence similarity to any other proteinamino acid sequences of known proteins, including cyclophilin . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7328 | 10.0979 | 1.0000 | This result suggests that two catalytically similar proteins, proteincyclophilin and FKBP , evolved independently. |
| 0.9013 | 1.0000 | 1.0000 | This result suggests that two catalytically similar proteins, cyclophilin and proteinFKBP , evolved independently. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5258 | 20.2456 | 1.0000 | In Northern blot analysis , RNAmRNA species of approximately 1.8 kilobases that hybridized with human FKBP cDNA were detected in poly(A)+ RNAs from brain , lung , liver , and placental cells and leukocytes . |
| 2.4597 | 20.8137 | 0.9999 | In Northern blot analysis , mRNA species of approximately 1.8 kilobases that hybridized with DNAhuman FKBP cDNA were detected in poly(A)+ RNAs from brain , lung , liver , and placental cells and leukocytes . |
| 2.3375 | 20.3489 | 1.0000 | In Northern blot analysis , mRNA species of approximately 1.8 kilobases that hybridized with human FKBP cDNA were detected in RNApoly(A)+ RNAs from brain , lung , liver , and placental cells and leukocytes . |
| 1.4711 | 10.9792 | 0.9998 | In Northern blot analysis , mRNA species of approximately 1.8 kilobases that hybridized with human FKBP cDNA were detected in poly(A)+ RNAs from brain , lung , liver , and cell_typeplacental cells and leukocytes . |
| 0.9482 | 1.0000 | 0.9941 | In Northern blot analysis , mRNA species of approximately 1.8 kilobases that hybridized with human proteinFKBP cDNA were detected in poly(A)+ RNAs from brain , lung , liver , and placental cells and leukocytes . |
| 0.8212 | 1.0000 | 0.9999 | In Northern blot analysis , mRNA species of approximately 1.8 kilobases that hybridized with human FKBP cDNA were detected in poly(A)+ RNAs from brain , lung , liver , and placental cells and cell_typeleukocytes . |
| 0.4568 | 0.9999 | 0.9999 | In Northern blot analysis , mRNA species of approximately 1.8 kilobases that hybridized with human DNAFKBP cDNA were detected in poly(A)+ RNAs from brain , lung , liver , and placental cells and leukocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6928 | 20.3979 | 10.8603 | Induction of cell_lineJurkat leukemic T cells with phorbol 12-myristate 13-acetate and ionomycin did not affect the level of FKBP mRNA . |
| 2.2753 | 20.9400 | 1.0000 | Induction of Jurkat leukemic T cells with phorbol 12-myristate 13-acetate and ionomycin did not affect the level of RNAFKBP mRNA . |
| 1.7110 | 20.9350 | 0.9812 | Induction of Jurkat leukemic T cells with phorbol 12-myristate 13-acetate and ionomycin did not affect the level of proteinFKBP mRNA . |
| Induction of Jurkat leukemic cell_typeT cells with phorbol 12-myristate 13-acetate and ionomycin did not affect the level of FKBP mRNA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6939 | 10.2824 | 1.0000 | Southern blot analysis of human genomic DNA digested with different restriction enzymes suggests the existence of only a few copies of the DNA sequence encoding proteinFKBP . |
| 1.2761 | 10.9713 | 0.9999 | Southern blot analysis of human genomic DNA digested with different proteinrestriction enzymes suggests the existence of only a few copies of the DNA sequence encoding FKBP . |
| 2.2803 | 20.9385 | 0.9999 | Southern blot analysis of human genomic DNA digested with different restriction enzymes suggests the existence of only a few copies of the DNADNA sequence encoding FKBP . |
| 1.2986 | 20.1150 | 0.9998 | Southern blot analysis of human DNAgenomic DNA digested with different restriction enzymes suggests the existence of only a few copies of the DNA sequence encoding FKBP . |
| Southern blot analysis of DNAhuman genomic DNA digested with different restriction enzymes suggests the existence of only a few copies of the DNA sequence encoding FKBP . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2851 | 20.1983 | 1.0000 | This is in contrast to the result that as many as 20 copies of the DNAcyclophilin gene and possible pseudogenes may be present in the mammalian genome . |
| 2.1306 | 20.2084 | 0.9890 | This is in contrast to the result that as many as 20 copies of the proteincyclophilin gene and possible pseudogenes may be present in the mammalian genome . |
| 1.5540 | 10.9059 | 0.9999 | This is in contrast to the result that as many as 20 copies of the cyclophilin gene and possible pseudogenes may be present in the DNAmammalian genome . |
| 1.7308 | 10.1298 | 1.0000 | This is in contrast to the result that as many as 20 copies of the cyclophilin gene and possible DNApseudogenes may be present in the mammalian genome . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4837 | 20.4364 | 10.6986 | Involvement of a second DNAlymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression . |
| 2.2395 | 20.8165 | 0.9999 | Involvement of a second lymphoid-specific enhancer element in the regulation of DNAimmunoglobulin heavy-chain gene expression . |
| 1.6218 | 20.6453 | 0.8427 | Involvement of a second lymphoid-specific enhancer element in the regulation of proteinimmunoglobulin heavy-chain gene expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8037 | 30.9015 | 10.9228 | To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the DNAimmunoglobulin heavy-chain (IgH) gene , we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor , designated NF-microB , in the murine IgH enhancer . |
| 1.9277 | 20.5681 | 0.9999 | To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene , we have investigated the effect of mutating the DNAbinding site for a putative additional lymphoid-specific transcription factor , designated NF-microB , in the murine IgH enhancer . |
| 1.8646 | 20.5717 | 0.9999 | To determine whether DNAenhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene , we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor , designated NF-microB , in the murine IgH enhancer . |
| 1.3938 | 0.9985 | 10.2259 | To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene , we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor , designated NF-microB , in the DNAmurine IgH enhancer . |
| 0.9113 | 1.0000 | 1.0000 | To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene , we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor , designated proteinNF-microB , in the murine IgH enhancer . |
| 6.1588 | 30.7886 | 20.2042 | To determine whether enhancer elements in addition to the DNAhighly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene , we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor , designated NF-microB , in the murine IgH enhancer . |
| 3.5827 | 30.3538 | 10.3207 | To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene , we have investigated the effect of mutating the binding site for a putative additional proteinlymphoid-specific transcription factor , designated NF-microB , in the murine IgH enhancer . |
| To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene , we have investigated the effect of mutating the binding site for a proteinputative additional lymphoid-specific transcription factor , designated NF-microB , in the murine IgH enhancer . | |||
| To determine whether enhancer elements in addition to the highly conserved DNAoctamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene , we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor , designated NF-microB , in the murine IgH enhancer . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2979 | 20.7130 | 1.0000 | We demonstrate that the DNANF-microB-binding site plays a critical role in the IgH enhancer , because mutation of the microB DNA motif decreased transcriptional activity of the IgH enhancer in cells of the B-cell lineage but not in nonlymphoid cells . |
| 2.1206 | 20.7085 | 0.9999 | We demonstrate that the NF-microB-binding site plays a critical role in the DNAIgH enhancer , because mutation of the microB DNA motif decreased transcriptional activity of the IgH enhancer in cells of the B-cell lineage but not in nonlymphoid cells . |
| 2.1101 | 20.3406 | 1.0000 | We demonstrate that the NF-microB-binding site plays a critical role in the IgH enhancer , because mutation of the microB DNA motif decreased transcriptional activity of the DNAIgH enhancer in cells of the B-cell lineage but not in nonlymphoid cells . |
| 1.4966 | 10.9615 | 0.9999 | We demonstrate that the NF-microB-binding site plays a critical role in the IgH enhancer , because mutation of the microB DNA motif decreased transcriptional activity of the IgH enhancer in cells of the cell_typeB-cell lineage but not in nonlymphoid cells . |
| 1.4547 | 10.8032 | 0.9997 | We demonstrate that the NF-microB-binding site plays a critical role in the IgH enhancer , because mutation of the microB DNA motif decreased transcriptional activity of the IgH enhancer in cells of the B-cell lineage but not in cell_typenonlymphoid cells . |
| 3.6098 | 20.7045 | 10.8074 | We demonstrate that the NF-microB-binding site plays a critical role in the IgH enhancer , because mutation of the DNAmicroB DNA motif decreased transcriptional activity of the IgH enhancer in cells of the B-cell lineage but not in nonlymphoid cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5841 | 10.6661 | 0.9999 | This effect was comparable to or even stronger than the effect of a mutation in the DNAOCTA site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2394 | 20.3548 | 0.9998 | Moreover, combined mutation of both microB and OCTA sites further reduced enhancer activity in cell_typelymphoid cells . |
| 0.5940 | 0.9999 | 0.9997 | Moreover, combined mutation of both DNAmicroB and OCTA sites further reduced enhancer activity in lymphoid cells . |
| 0.6877 | 0.9996 | 0.9950 | Moreover, combined mutation of both microB and DNAOCTA sites further reduced enhancer activity in lymphoid cells . |
| Moreover, combined mutation of both microB and DNAOCTA sites further reduced enhancer activity in lymphoid cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3151 | 20.4751 | 0.9999 | Interestingly, alteration of either the microB or E3 site in a DNA70-base-pair fragment of the IgH enhancer that lacks the binding site for OCTA abolished enhancer activity in lymphoid cells completely. |
| 1.5237 | 10.8349 | 0.9999 | Interestingly, alteration of either the microB or E3 site in a 70-base-pair fragment of the DNAIgH enhancer that lacks the binding site for OCTA abolished enhancer activity in lymphoid cells completely. |
| 1.5061 | 10.8455 | 0.9997 | Interestingly, alteration of either the microB or E3 site in a 70-base-pair fragment of the IgH enhancer that lacks the binding site for OCTA abolished enhancer activity in cell_typelymphoid cells completely. |
| 1.5203 | 20.5256 | 0.9993 | Interestingly, alteration of either the microB or E3 site in a 70-base-pair fragment of the IgH enhancer that lacks the DNAbinding site for OCTA abolished enhancer activity in lymphoid cells completely. |
| 0.8822 | 0.9999 | 1.0000 | Interestingly, alteration of either the microB or E3 site in a 70-base-pair fragment of the IgH enhancer that lacks the binding site for proteinOCTA abolished enhancer activity in lymphoid cells completely. |
| Interestingly, alteration of either the DNAmicroB or E3 site in a 70-base-pair fragment of the IgH enhancer that lacks the binding site for OCTA abolished enhancer activity in lymphoid cells completely. | |||
| Interestingly, alteration of either the microB or DNAE3 site in a 70-base-pair fragment of the IgH enhancer that lacks the binding site for OCTA abolished enhancer activity in lymphoid cells completely. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3656 | 20.0020 | 1.0000 | Nevertheless, a multimer of the DNAmicroB motif alone showed no enhancer activity . |
| Nevertheless, a multimer of the DNAmicroB motif alone showed no enhancer activity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0036 | 20.3530 | 10.5982 | DNase footprinting analysis corroborated the functional data showing that a lymphoid-specific protein binds to the DNAmicroB DNA motif . |
| 2.1630 | 20.2675 | 1.0000 | DNase footprinting analysis corroborated the functional data showing that a proteinlymphoid-specific protein binds to the microB DNA motif . |
| 0.9724 | 1.0000 | 1.0000 | proteinDNase footprinting analysis corroborated the functional data showing that a lymphoid-specific protein binds to the microB DNA motif . |
| DNase footprinting analysis corroborated the functional data showing that a lymphoid-specific protein binds to the DNAmicroB DNA motif . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3610 | 20.3149 | 1.0000 | Our results suggest that the DNAmicroB element is a new crucial element important for lymphoid-specific expression of the IgH gene but that interaction with another enhancer element is essential for its activity. |
| 2.2960 | 20.3109 | 1.0000 | Our results suggest that the microB element is a new crucial element important for lymphoid-specific expression of the IgH gene but that interaction with another DNAenhancer element is essential for its activity. |
| 1.6083 | 20.3189 | 0.9721 | Our results suggest that the DNAmicroB element is a new crucial element important for lymphoid-specific expression of the IgH gene but that interaction with another enhancer element is essential for its activity. |
| 2.3985 | 20.3150 | 1.0000 | Our results suggest that the microB element is a new crucial element important for lymphoid-specific expression of the DNAIgH gene but that interaction with another enhancer element is essential for its activity. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2577 | 30.0957 | 10.0951 | Stimulation of the human immunodeficiency virus type 2 ( HIV-2 ) gene expression by the cytomegalovirus and DNAHIV-2 transactivator gene . |
| 5.6278 | 20.8189 | 30.5220 | Stimulation of the DNAhuman immunodeficiency virus type 2 ( HIV-2 ) gene expression by the cytomegalovirus and HIV-2 transactivator gene . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4834 | 10.9467 | 10.5681 | The DNAtransactivator (IE-2) gene of the human cytomegalovirus ( CMV ) can enhance HIV-2 as well as HIV-1 gene expression in vitro. |
| 1.9876 | 20.4124 | 0.9998 | The transactivator (IE-2) gene of the human cytomegalovirus ( CMV ) can enhance HIV-2 as well as DNAHIV-1 gene expression in vitro. |
| 0.5957 | 1.0000 | 0.9930 | The proteintransactivator (IE-2) gene of the human cytomegalovirus ( CMV ) can enhance HIV-2 as well as HIV-1 gene expression in vitro. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7061 | 20.9067 | 10.7469 | This inducer can act in concert with the HIV-2 tat gene and T-cell activation in enhancing gene expression in cell_typehuman CD4+ lymphocytes . |
| 3.7012 | 20.6387 | 10.5519 | This inducer can act in concert with the DNAHIV-2 tat gene and T-cell activation in enhancing gene expression in human CD4+ lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5668 | 10.8879 | 0.9999 | While the HIV-2 and HIV-1 tat genes and proteinT-cell activators apparently employ independent modes of action, the CMV transactivator in combination with the HIV-2 tat or T-cell activators may employ a gene activation pathway with some common and some distinct components. |
| 1.3041 | 10.9762 | 0.9999 | While the HIV-2 and HIV-1 tat genes and T-cell activators apparently employ independent modes of action, the CMV transactivator in combination with the HIV-2 tat or proteinT-cell activators may employ a gene activation pathway with some common and some distinct components. |
| 2.2844 | 20.8420 | 1.0000 | While the HIV-2 and HIV-1 tat genes and T-cell activators apparently employ independent modes of action, the proteinCMV transactivator in combination with the HIV-2 tat or T-cell activators may employ a gene activation pathway with some common and some distinct components. |
| 1.3459 | 10.1573 | 0.9999 | While the HIV-2 and HIV-1 tat genes and T-cell activators apparently employ independent modes of action, the CMV transactivator in combination with the proteinHIV-2 tat or T-cell activators may employ a gene activation pathway with some common and some distinct components. |
| While the HIV-2 and DNAHIV-1 tat genes and T-cell activators apparently employ independent modes of action, the CMV transactivator in combination with the HIV-2 tat or T-cell activators may employ a gene activation pathway with some common and some distinct components. | |||
| While the HIV-2 and HIV-1 tat genes and T-cell activators apparently employ independent modes of action, the CMV transactivator in combination with the DNAHIV-2 tat or T-cell activators may employ a gene activation pathway with some common and some distinct components. | |||
| While the HIV-2 and HIV-1 tat genes and T-cell activators apparently employ independent modes of action, the DNACMV transactivator in combination with the HIV-2 tat or T-cell activators may employ a gene activation pathway with some common and some distinct components. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5817 | 10.8181 | 1.0000 | Both HIV-2 and CMV transactivators enhance HIV-2 gene expression by transcriptional activation involving transcript initiation as well as elongation , with proteinCMV transactivator affecting elongation more than the initiation . |
| 1.1248 | 10.2440 | 1.0000 | Both HIV-2 and proteinCMV transactivators enhance HIV-2 gene expression by transcriptional activation involving transcript initiation as well as elongation , with CMV transactivator affecting elongation more than the initiation . |
| Both HIV-2 and CMV transactivators enhance HIV-2 gene expression by transcriptional activation involving transcript initiation as well as elongation , with DNACMV transactivator affecting elongation more than the initiation . | |||
| Both HIV-2 and CMV proteintransactivators enhance HIV-2 gene expression by transcriptional activation involving transcript initiation as well as elongation , with CMV transactivator affecting elongation more than the initiation . | |||
| Both HIV-2 and DNACMV transactivators enhance HIV-2 gene expression by transcriptional activation involving transcript initiation as well as elongation , with CMV transactivator affecting elongation more than the initiation . | |||
| Both HIV-2 and CMV transactivators enhance HIV-2 gene expression by transcriptional activation involving transcript initiation as well as elongation , with CMV proteintransactivator affecting elongation more than the initiation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3526 | 20.0184 | 1.0000 | A significant proportion of transcripts appear to terminate prematurely in the absence of proteintransactivators . |
| 1.1845 | 10.6226 | 1.0000 | A significant proportion of RNAtranscripts appear to terminate prematurely in the absence of transactivators . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9464 | 20.7994 | 10.6033 | Deletion mutation analysis of the DNAHIV-2 long terminal repeat ( LTR ) suggests that the element that responds to CMV transactivation in human CD4+ lymphocytes is either a diffuse one or located downstream of the HIV-2 enhancer element . |
| 3.9378 | 30.0084 | 10.5616 | Deletion mutation analysis of the HIV-2 long terminal repeat ( LTR ) suggests that the element that responds to CMV transactivation in human CD4+ lymphocytes is either a diffuse one or located downstream of the DNAHIV-2 enhancer element . |
| 0.9396 | 1.0000 | 1.0000 | Deletion mutation analysis of the HIV-2 long terminal repeat ( DNALTR ) suggests that the element that responds to CMV transactivation in human CD4+ lymphocytes is either a diffuse one or located downstream of the HIV-2 enhancer element . |
| 3.8871 | 20.3141 | 10.8423 | Deletion mutation analysis of the HIV-2 long terminal repeat ( LTR ) suggests that the element that responds to CMV transactivation in cell_linehuman CD4+ lymphocytes is either a diffuse one or located downstream of the HIV-2 enhancer element . |
| Deletion mutation analysis of the HIV-2 long terminal repeat ( LTR ) suggests that the element that responds to CMV transactivation in cell_typehuman CD4+ lymphocytes is either a diffuse one or located downstream of the HIV-2 enhancer element . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5652 | 10.9919 | 1.0000 | Quantitative immunohistochemical analysis of cell_typemononuclear infiltrates in breast carcinomas --correlation with tumour differentiation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9513 | 20.5433 | 10.7438 | Inflammatory infiltrates were analysed in tissue sections of 76 breast carcinomas by counting the percentage of macrophages , IgA+ and IgG+ plasma cells , T cells with their subpopulations, and cell_typenatural killer cells , and by measuring postcapillary venules ( PCVs , found in 12 cases) within the infiltrates. |
| 2.5306 | 20.9212 | 0.9999 | Inflammatory infiltrates were analysed in tissue sections of 76 breast carcinomas by counting the percentage of macrophages , IgA+ and IgG+ plasma cells , cell_typeT cells with their subpopulations, and natural killer cells , and by measuring postcapillary venules ( PCVs , found in 12 cases) within the infiltrates. |
| 0.9186 | 1.0000 | 1.0000 | Inflammatory infiltrates were analysed in tissue sections of 76 breast carcinomas by counting the percentage of cell_typemacrophages , IgA+ and IgG+ plasma cells , T cells with their subpopulations, and natural killer cells , and by measuring postcapillary venules ( PCVs , found in 12 cases) within the infiltrates. |
| 0.8147 | 0.9988 | 0.9999 | cell_typeInflammatory infiltrates were analysed in tissue sections of 76 breast carcinomas by counting the percentage of macrophages , IgA+ and IgG+ plasma cells , T cells with their subpopulations, and natural killer cells , and by measuring postcapillary venules ( PCVs , found in 12 cases) within the infiltrates. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7067 | 10.7742 | 1.0000 | These parameters were correlated with nuclear grade and biochemically determined proteinhormone receptor status , known markers of tumour differentiation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4638 | 20.7881 | 1.0000 | A direct correlation was found between the extent of inflammation and nuclear grade (P less than 0.0001), and an inverse correlation between inflammation and proteinoestrogen receptor ( OR ) positivity (P less than 0.05) as well as inflammation and progesterone receptor ( PR ) positivity (P less than 0.05). |
| 2.4612 | 20.7878 | 1.0000 | A direct correlation was found between the extent of inflammation and nuclear grade (P less than 0.0001), and an inverse correlation between inflammation and oestrogen receptor ( OR ) positivity (P less than 0.05) as well as inflammation and proteinprogesterone receptor ( PR ) positivity (P less than 0.05). |
| 0.9813 | 1.0000 | 1.0000 | A direct correlation was found between the extent of inflammation and nuclear grade (P less than 0.0001), and an inverse correlation between inflammation and oestrogen receptor ( OR ) positivity (P less than 0.05) as well as inflammation and progesterone receptor ( proteinPR ) positivity (P less than 0.05). |
| 0.9704 | 1.0000 | 1.0000 | A direct correlation was found between the extent of inflammation and nuclear grade (P less than 0.0001), and an inverse correlation between inflammation and oestrogen receptor ( proteinOR ) positivity (P less than 0.05) as well as inflammation and progesterone receptor ( PR ) positivity (P less than 0.05). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.5600 | 30.3298 | 10.7901 | The percentage of the cell_typeOKT8+ suppressor/cytotoxic T cells increased when the inflammation expanded from scanty to moderate (P less than 0.02). |
| The percentage of the OKT8+ suppressor/cytotoxic cell_typeT cells increased when the inflammation expanded from scanty to moderate (P less than 0.02). | |||
| The percentage of the cell_lineOKT8+ suppressor/cytotoxic T cells increased when the inflammation expanded from scanty to moderate (P less than 0.02). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3194 | 10.1553 | 1.0000 | The diameter of the DNAPCVs also increased with increasing inflammatory infiltrate (P less than 0.02). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0972 | 30.2830 | 10.4171 | In addition, a direct correlation exists between the diameter of the PCVs and both the percentage of the OKT8+ T cells (P less than 0.04) and the cell_typeLeu-7+ natural killer cells (P less than 0.03). |
| 3.8517 | 30.3863 | 10.7185 | In addition, a direct correlation exists between the diameter of the PCVs and both the percentage of the cell_typeOKT8+ T cells (P less than 0.04) and the Leu-7+ natural killer cells (P less than 0.03). |
| 1.4941 | 10.4375 | 1.0000 | In addition, a direct correlation exists between the diameter of the DNAPCVs and both the percentage of the OKT8+ T cells (P less than 0.04) and the Leu-7+ natural killer cells (P less than 0.03). |
| In addition, a direct correlation exists between the diameter of the PCVs and both the percentage of the cell_lineOKT8+ T cells (P less than 0.04) and the Leu-7+ natural killer cells (P less than 0.03). | |||
| In addition, a direct correlation exists between the diameter of the PCVs and both the percentage of the OKT8+ cell_typeT cells (P less than 0.04) and the Leu-7+ natural killer cells (P less than 0.03). | |||
| In addition, a direct correlation exists between the diameter of the PCVs and both the percentage of the OKT8+ T cells (P less than 0.04) and the Leu-7+ cell_typenatural killer cells (P less than 0.03). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5141 | 20.2463 | 10.5917 | Reactivity of lymphocytes to a proteinprogesterone receptor-specific monoclonal antibody . |
| 1.3929 | 10.9587 | 1.0000 | Reactivity of cell_typelymphocytes to a progesterone receptor-specific monoclonal antibody . |
| Reactivity of cell_linelymphocytes to a progesterone receptor-specific monoclonal antibody . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3770 | 20.6803 | 10.8064 | In this study we present evidence for reactivity of pregnancy lymphocytes , but not nonpregnancy lymphocytes , with the proteinprogesterone receptor-specific monoclonal antibody mPRI . |
| 1.9848 | 20.2415 | 0.9998 | In this study we present evidence for reactivity of pregnancy lymphocytes , but not cell_typenonpregnancy lymphocytes , with the progesterone receptor-specific monoclonal antibody mPRI . |
| 1.9791 | 20.5400 | 0.9999 | In this study we present evidence for reactivity of cell_typepregnancy lymphocytes , but not nonpregnancy lymphocytes , with the progesterone receptor-specific monoclonal antibody mPRI . |
| 0.9685 | 0.9999 | 1.0000 | In this study we present evidence for reactivity of pregnancy lymphocytes , but not nonpregnancy lymphocytes , with the progesterone receptor-specific monoclonal antibody proteinmPRI . |
| In this study we present evidence for reactivity of pregnancy lymphocytes , but not nonpregnancy cell_linelymphocytes , with the progesterone receptor-specific monoclonal antibody mPRI . | |||
| In this study we present evidence for reactivity of pregnancy cell_linelymphocytes , but not nonpregnancy lymphocytes , with the progesterone receptor-specific monoclonal antibody mPRI . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4383 | 20.8174 | 1.0000 | Using an avidin -biotin peroxidase detection system , we found a nuclear staining in 14.6 +/- 3.7% (mean +/- SEM, N = 27) of pregnancy lymphocytes , while only 0.47 +/- 0.33% (mean +/- SEM, N = 15) of cell_typenonpregnancy lymphocytes reacted with the antibody. |
| 2.4047 | 20.5079 | 1.0000 | Using an avidin -biotin peroxidase detection system , we found a nuclear staining in 14.6 +/- 3.7% (mean +/- SEM, N = 27) of cell_typepregnancy lymphocytes , while only 0.47 +/- 0.33% (mean +/- SEM, N = 15) of nonpregnancy lymphocytes reacted with the antibody. |
| 1.7478 | 10.0317 | 0.9999 | Using an proteinavidin -biotin peroxidase detection system , we found a nuclear staining in 14.6 +/- 3.7% (mean +/- SEM, N = 27) of pregnancy lymphocytes , while only 0.47 +/- 0.33% (mean +/- SEM, N = 15) of nonpregnancy lymphocytes reacted with the antibody. |
| 0.6870 | 0.9999 | 0.9997 | Using an avidin protein-biotin peroxidase detection system , we found a nuclear staining in 14.6 +/- 3.7% (mean +/- SEM, N = 27) of pregnancy lymphocytes , while only 0.47 +/- 0.33% (mean +/- SEM, N = 15) of nonpregnancy lymphocytes reacted with the antibody. |
| 1.9930 | 20.2803 | 0.9997 | Using an proteinavidin -biotin peroxidase detection system , we found a nuclear staining in 14.6 +/- 3.7% (mean +/- SEM, N = 27) of pregnancy lymphocytes , while only 0.47 +/- 0.33% (mean +/- SEM, N = 15) of nonpregnancy lymphocytes reacted with the antibody. |
| Using an avidin -biotin peroxidase detection system , we found a nuclear staining in 14.6 +/- 3.7% (mean +/- SEM, N = 27) of pregnancy lymphocytes , while only 0.47 +/- 0.33% (mean +/- SEM, N = 15) of nonpregnancy cell_linelymphocytes reacted with the antibody. | |||
| Using an avidin -biotin peroxidase detection system , we found a nuclear staining in 14.6 +/- 3.7% (mean +/- SEM, N = 27) of pregnancy cell_linelymphocytes , while only 0.47 +/- 0.33% (mean +/- SEM, N = 15) of nonpregnancy lymphocytes reacted with the antibody. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6085 | 20.4195 | 0.9376 | Depletion of CD8+ cells was accompanied by 62 +/- 18% loss of proteinprogesterone receptor -bearing cells , while depletion of CD4+ cells resulted in a twofold increase in the number of positively staining lymphocytes . |
| 3.6964 | 20.4889 | 10.6355 | Depletion of CD8+ cells was accompanied by 62 +/- 18% loss of cell_typeprogesterone receptor -bearing cells , while depletion of CD4+ cells resulted in a twofold increase in the number of positively staining lymphocytes . |
| 2.7487 | 20.3451 | 10.8311 | Depletion of CD8+ cells was accompanied by 62 +/- 18% loss of progesterone receptor -bearing cells , while depletion of CD4+ cells resulted in a twofold increase in the number of cell_typepositively staining lymphocytes . |
| 2.2364 | 20.5681 | 0.9999 | Depletion of CD8+ cells was accompanied by 62 +/- 18% loss of progesterone receptor -bearing cells , while depletion of cell_typeCD4+ cells resulted in a twofold increase in the number of positively staining lymphocytes . |
| 2.2309 | 20.4864 | 0.9999 | Depletion of cell_typeCD8+ cells was accompanied by 62 +/- 18% loss of progesterone receptor -bearing cells , while depletion of CD4+ cells resulted in a twofold increase in the number of positively staining lymphocytes . |
| Depletion of CD8+ cells was accompanied by 62 +/- 18% loss of progesterone receptor -bearing cells , while depletion of CD4+ cells resulted in a twofold increase in the number of positively staining cell_linelymphocytes . | |||
| Depletion of CD8+ cells was accompanied by 62 +/- 18% loss of cell_lineprogesterone receptor -bearing cells , while depletion of CD4+ cells resulted in a twofold increase in the number of positively staining lymphocytes . | |||
| Depletion of CD8+ cells was accompanied by 62 +/- 18% loss of progesterone receptor -bearing cells , while depletion of cell_lineCD4+ cells resulted in a twofold increase in the number of positively staining lymphocytes . | |||
| Depletion of cell_lineCD8+ cells was accompanied by 62 +/- 18% loss of progesterone receptor -bearing cells , while depletion of CD4+ cells resulted in a twofold increase in the number of positively staining lymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3549 | 20.8375 | 0.9999 | In nonpregnancy lymphocytes a 3-day PHA treatment , as well as allogeneic stimulation, resulted in a significant increase in the number of cell_typereceptor-containing cells . |
| 1.8469 | 10.1162 | 1.0000 | In nonpregnancy lymphocytes a 3-day proteinPHA treatment , as well as allogeneic stimulation, resulted in a significant increase in the number of receptor-containing cells . |
| 1.5574 | 10.8659 | 0.9998 | In cell_typenonpregnancy lymphocytes a 3-day PHA treatment , as well as allogeneic stimulation, resulted in a significant increase in the number of receptor-containing cells . |
| In cell_linenonpregnancy lymphocytes a 3-day PHA treatment , as well as allogeneic stimulation, resulted in a significant increase in the number of receptor-containing cells . | |||
| In nonpregnancy cell_linelymphocytes a 3-day PHA treatment , as well as allogeneic stimulation, resulted in a significant increase in the number of receptor-containing cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2501 | 10.9560 | 10.8856 | These results suggest that pregnancy , but not nonpregnancy , lymphocytes contain proteinprogesterone binding structures , and that these are inducible by mitogenic or alloantigenic stimuli . |
| 0.9239 | 1.0000 | 1.0000 | These results suggest that pregnancy , but not nonpregnancy , cell_typelymphocytes contain progesterone binding structures , and that these are inducible by mitogenic or alloantigenic stimuli . |
| These results suggest that pregnancy , but not nonpregnancy , cell_linelymphocytes contain progesterone binding structures , and that these are inducible by mitogenic or alloantigenic stimuli . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8637 | 10.9698 | 10.5979 | Activation of cell_typehuman CD4 T lymphocytes . |
| Activation of cell_linehuman CD4 T lymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3914 | 10.0033 | 1.0000 | Interaction of fibronectin with proteinVLA-5 receptor on CD4 cells induces the AP-1 transcription factor . |
| 1.3648 | 10.5670 | 1.0000 | Interaction of proteinfibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor . |
| 1.0206 | 10.5766 | 0.9995 | Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the proteinAP-1 transcription factor . |
| 1.3720 | 10.6258 | 0.9998 | Interaction of fibronectin with VLA-5 receptor on cell_typeCD4 cells induces the AP-1 transcription factor . |
| 1.2869 | 10.8573 | 0.9991 | Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the proteinAP-1 transcription factor . |
| Interaction of fibronectin with VLA-5 receptor on cell_lineCD4 cells induces the AP-1 transcription factor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7470 | 10.0697 | 1.0000 | Fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system whereas no proliferation was observed when CD4 cells were cultured with proteinanti-CD3 alone or fibronectin alone. |
| 1.5551 | 10.2849 | 1.0000 | Fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system whereas no proliferation was observed when CD4 cells were cultured with anti-CD3 alone or proteinfibronectin alone. |
| 1.4973 | 10.7417 | 1.0000 | Fibronectin synergized with proteinanti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system whereas no proliferation was observed when CD4 cells were cultured with anti-CD3 alone or fibronectin alone. |
| 0.9689 | 1.0000 | 1.0000 | proteinFibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system whereas no proliferation was observed when CD4 cells were cultured with anti-CD3 alone or fibronectin alone. |
| 1.4755 | 10.9547 | 0.9999 | Fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system whereas no proliferation was observed when cell_typeCD4 cells were cultured with anti-CD3 alone or fibronectin alone. |
| 1.4680 | 10.8289 | 0.9999 | Fibronectin synergized with anti-CD3 antibody to promote cell_typeCD4 cell proliferation in a serum-free culture system whereas no proliferation was observed when CD4 cells were cultured with anti-CD3 alone or fibronectin alone. |
| Fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system whereas no proliferation was observed when cell_lineCD4 cells were cultured with anti-CD3 alone or fibronectin alone. | |||
| Fibronectin synergized with anti-CD3 antibody to promote proteinCD4 cell proliferation in a serum-free culture system whereas no proliferation was observed when CD4 cells were cultured with anti-CD3 alone or fibronectin alone. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8316 | 10.9949 | 10.9289 | In addition, anti-CD29 ( proteinintegrin beta 1 ) as well as anti-VLA-5 ( human fibronectin receptor ) antibodies blocked this CD4 cell activation in this system. |
| 1.5514 | 10.6655 | 1.0000 | In addition, proteinanti-CD29 ( integrin beta 1 ) as well as anti-VLA-5 ( human fibronectin receptor ) antibodies blocked this CD4 cell activation in this system. |
| 0.8321 | 1.0000 | 0.9237 | In addition, anti-CD29 ( integrin beta 1 ) as well as anti-VLA-5 ( proteinhuman fibronectin receptor ) antibodies blocked this CD4 cell activation in this system. |
| 3.3980 | 20.8673 | 10.9198 | In addition, anti-CD29 ( integrin beta 1 ) as well as proteinanti-VLA-5 ( human fibronectin receptor ) antibodies blocked this CD4 cell activation in this system. |
| In addition, anti-CD29 ( integrin beta 1 ) as well as anti-VLA-5 ( human proteinfibronectin receptor ) antibodies blocked this CD4 cell activation in this system. | |||
| In addition, anti-CD29 ( integrin beta 1 ) as well as proteinanti-VLA-5 ( human fibronectin receptor ) antibodies blocked this CD4 cell activation in this system. | |||
| In addition, anti-CD29 ( integrin beta 1 ) as well as anti-VLA-5 ( human fibronectin receptor ) antibodies blocked this cell_lineCD4 cell activation in this system. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6441 | 10.0361 | 1.0000 | Although anti-CD3 alone or proteinfibronectin alone cannot induce IL-2 message by CD4 cells , the combination of anti-CD3 plus fibronectin induced IL-2 message by CD4 cells . |
| 1.5554 | 10.3154 | 1.0000 | Although anti-CD3 alone or fibronectin alone cannot induce proteinIL-2 message by CD4 cells , the combination of anti-CD3 plus fibronectin induced IL-2 message by CD4 cells . |
| 1.5246 | 10.8340 | 1.0000 | Although anti-CD3 alone or fibronectin alone cannot induce IL-2 message by CD4 cells , the combination of proteinanti-CD3 plus fibronectin induced IL-2 message by CD4 cells . |
| 0.9209 | 0.9999 | 1.0000 | Although proteinanti-CD3 alone or fibronectin alone cannot induce IL-2 message by CD4 cells , the combination of anti-CD3 plus fibronectin induced IL-2 message by CD4 cells . |
| 0.8856 | 1.0000 | 1.0000 | Although anti-CD3 alone or fibronectin alone cannot induce IL-2 message by CD4 cells , the combination of anti-CD3 plus proteinfibronectin induced IL-2 message by CD4 cells . |
| 0.8569 | 1.0000 | 1.0000 | Although anti-CD3 alone or fibronectin alone cannot induce IL-2 message by CD4 cells , the combination of anti-CD3 plus fibronectin induced proteinIL-2 message by CD4 cells . |
| 1.4382 | 10.7543 | 0.9999 | Although anti-CD3 alone or fibronectin alone cannot induce IL-2 message by cell_typeCD4 cells , the combination of anti-CD3 plus fibronectin induced IL-2 message by CD4 cells . |
| 1.4032 | 10.6096 | 0.9998 | Although anti-CD3 alone or fibronectin alone cannot induce IL-2 message by CD4 cells , the combination of anti-CD3 plus fibronectin induced IL-2 message by cell_typeCD4 cells . |
| Although anti-CD3 alone or fibronectin alone cannot induce IL-2 message by cell_lineCD4 cells , the combination of anti-CD3 plus fibronectin induced IL-2 message by CD4 cells . | |||
| Although anti-CD3 alone or fibronectin alone cannot induce IL-2 message by CD4 cells , the combination of anti-CD3 plus fibronectin induced IL-2 message by cell_lineCD4 cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7194 | 20.8034 | 10.5816 | In an analysis of the molecular mechanism by which IL-2 message was generated, we showed that a fibronectin -VLA-5 fibronectin receptor interaction may contribute an independent signal distinct from the CD3 pathway of activation by the induction of an proteinAP-1 transcriptional factor . |
| 1.6549 | 10.2527 | 1.0000 | In an analysis of the molecular mechanism by which IL-2 message was generated, we showed that a fibronectin -VLA-5 fibronectin receptor interaction may contribute an independent signal distinct from the proteinCD3 pathway of activation by the induction of an AP-1 transcriptional factor . |
| 1.6021 | 10.4501 | 0.9982 | In an analysis of the molecular mechanism by which IL-2 message was generated, we showed that a proteinfibronectin -VLA-5 fibronectin receptor interaction may contribute an independent signal distinct from the CD3 pathway of activation by the induction of an AP-1 transcriptional factor . |
| 1.5326 | 10.5802 | 1.0000 | In an analysis of the molecular mechanism by which proteinIL-2 message was generated, we showed that a fibronectin -VLA-5 fibronectin receptor interaction may contribute an independent signal distinct from the CD3 pathway of activation by the induction of an AP-1 transcriptional factor . |
| 0.9710 | 1.0000 | 0.9859 | In an analysis of the molecular mechanism by which IL-2 message was generated, we showed that a fibronectin -VLA-5 proteinfibronectin receptor interaction may contribute an independent signal distinct from the CD3 pathway of activation by the induction of an AP-1 transcriptional factor . |
| 0.8959 | 0.9988 | 1.0000 | In an analysis of the molecular mechanism by which IL-2 message was generated, we showed that a fibronectin -VLA-5 proteinfibronectin receptor interaction may contribute an independent signal distinct from the CD3 pathway of activation by the induction of an AP-1 transcriptional factor . |
| 2.0332 | 20.7111 | 0.9998 | In an analysis of the molecular mechanism by which IL-2 message was generated, we showed that a proteinfibronectin -VLA-5 fibronectin receptor interaction may contribute an independent signal distinct from the CD3 pathway of activation by the induction of an AP-1 transcriptional factor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6481 | 20.2944 | 10.2472 | Thus the proteinVLA-5 fibronectin receptor on CD4 cells can play a complementary role in CD3 - TCR -mediated signal transduction through its interaction with fibronectin . |
| 1.4783 | 10.3906 | 1.0000 | Thus the VLA-5 fibronectin receptor on CD4 cells can play a complementary role in CD3 - TCR -mediated signal transduction through its interaction with proteinfibronectin . |
| 0.9749 | 1.0000 | 1.0000 | Thus the VLA-5 fibronectin receptor on CD4 cells can play a complementary role in CD3 - proteinTCR -mediated signal transduction through its interaction with fibronectin . |
| 0.9064 | 1.0000 | 0.9713 | Thus the VLA-5 proteinfibronectin receptor on CD4 cells can play a complementary role in CD3 - TCR -mediated signal transduction through its interaction with fibronectin . |
| 0.8838 | 0.9996 | 1.0000 | Thus the VLA-5 fibronectin receptor on CD4 cells can play a complementary role in proteinCD3 - TCR -mediated signal transduction through its interaction with fibronectin . |
| 1.4515 | 10.7955 | 0.9996 | Thus the VLA-5 fibronectin receptor on cell_typeCD4 cells can play a complementary role in CD3 - TCR -mediated signal transduction through its interaction with fibronectin . |
| Thus the VLA-5 fibronectin receptor on cell_lineCD4 cells can play a complementary role in CD3 - TCR -mediated signal transduction through its interaction with fibronectin . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4732 | 10.8455 | 0.9999 | Glucocorticoid receptors on cell_typemononuclear leukocytes in Alzheimer's disease . |
| 0.8580 | 0.9992 | 1.0000 | proteinGlucocorticoid receptors on mononuclear leukocytes in Alzheimer's disease . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3684 | 20.2330 | 1.0000 | In an exploration of the potential role of the glucocorticoid receptor (GR) in AD , GR density and affinity were assessed on cell_typemononuclear leukocytes of 12 AD patients and 12 healthy controls . |
| 2.3184 | 20.7241 | 1.0000 | In an exploration of the potential role of the proteinglucocorticoid receptor (GR) in AD , GR density and affinity were assessed on mononuclear leukocytes of 12 AD patients and 12 healthy controls . |
| 0.9589 | 1.0000 | 1.0000 | In an exploration of the potential role of the glucocorticoid receptor (GR) in AD , proteinGR density and affinity were assessed on mononuclear leukocytes of 12 AD patients and 12 healthy controls . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9909 | 1.0000 | 1.0000 | proteinGR binding characteristics did not differ between patients and controls or between patients subdivided according to diagnosis or associated clinical features. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7809 | 10.6902 | 1.0000 | These data suggest that the abnormalities of the HPA system in AD are not related to a proteinGR deficiency . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7930 | 20.4194 | 10.7370 | Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers : a role for proteinhematopoietic growth factor release by tumor cells ? |
| 2.2303 | 20.0783 | 0.9997 | Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers : a role for hematopoietic growth factor release by cell_typetumor cells ? |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5563 | 10.4426 | 0.9999 | One hundred six primary breast cancer samples were analysed for c-erbB2 , int-2 , and DNAc-myc gene amplification . |
| 0.8851 | 1.0000 | 1.0000 | One hundred six primary breast cancer samples were analysed for DNAc-erbB2 , int-2 , and c-myc gene amplification . |
| 0.5763 | 0.9996 | 1.0000 | One hundred six primary breast cancer samples were analysed for c-erbB2 , DNAint-2 , and c-myc gene amplification . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1344 | 10.8799 | 10.6112 | Amplified DNAc-erbB2 gene sequences were present in 21.5% of all samples. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8306 | 10.2990 | 1.0000 | Int-2 was amplified in 13.1% and DNAc-myc was amplified in 10.3%. |
| 0.5352 | 1.0000 | 1.0000 | proteinInt-2 was amplified in 13.1% and c-myc was amplified in 10.3%. |
| DNAInt-2 was amplified in 13.1% and c-myc was amplified in 10.3%. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6752 | 10.1471 | 1.0000 | In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or proteinprogesterone receptor ( PR ) (P = .011) expression. |
| 0.9833 | 1.0000 | 1.0000 | In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor ( proteinPR ) (P = .011) expression. |
| 2.3794 | 20.5310 | 0.9999 | In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of c-erbB2 amplification and absence of proteinestrogen receptor (ER) (P = .0009) or progesterone receptor ( PR ) (P = .011) expression. |
| 1.7287 | 10.4478 | 1.0000 | In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of proteinc-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor ( PR ) (P = .011) expression. |
| In a non-parametric test (Kruskal-Wallis) a strong negative association was found between high levels of DNAc-erbB2 amplification and absence of estrogen receptor (ER) (P = .0009) or progesterone receptor ( PR ) (P = .011) expression. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8428 | 10.2261 | 1.0000 | No correlations were found between all or high levels of amplification of each DNAoncogene separately or combined with T, N, grade, multifocality of tumor , or associated carcinoma in situ. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6475 | 10.6729 | 1.0000 | There was a trend approaching statistical significance for patients with DNAc-erbB2 amplifications to have positive lymph nodes at surgery (P = 0.09). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.1283 | 10.5111 | 1.0000 | A somewhat surprising finding however was a very strong association between DNAoncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each oncogene separately (P = .0048) or in combination (P = .0007). |
| 1.8707 | 10.5722 | 1.0000 | A somewhat surprising finding however was a very strong association between oncogene amplification and dense lymphocyte infiltration of the tumor (P = .05). This correlation is even stronger when only high levels of amplification are considered, either for each DNAoncogene separately (P = .0048) or in combination (P = .0007). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9363 | 1.0000 | 1.0000 | We propose that malignant cell proteincytokine production may help explain this observation. |
| 1.4637 | 10.3873 | 0.9999 | We propose that proteinmalignant cell cytokine production may help explain this observation. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6791 | 20.7642 | 10.7688 | Suppression of signals required for activation of proteintranscription factor NF-kappa B in cells constitutively expressing the HTLV-I Tax protein . |
| 3.6356 | 20.8382 | 10.6464 | Suppression of signals required for activation of transcription factor NF-kappa B in cells constitutively expressing the proteinHTLV-I Tax protein . |
| 0.8458 | 0.9986 | 0.9999 | Suppression of signals required for activation of transcription factor proteinNF-kappa B in cells constitutively expressing the HTLV-I Tax protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0026 | 20.7076 | 1.0000 | Transient short-term expression of the proteinTax protein of human T-cell leukemia virus type-I ( HTLV-I ) leads to activation of the pleiotropic transcription factor NF-kappa B . |
| 0.9042 | 0.9955 | 0.9999 | Transient short-term expression of the Tax protein of human T-cell leukemia virus type-I ( HTLV-I ) leads to activation of the pleiotropic transcription factor proteinNF-kappa B . |
| 5.5604 | 30.4850 | 10.7076 | Transient short-term expression of the Tax protein of human T-cell leukemia virus type-I ( HTLV-I ) leads to activation of the proteinpleiotropic transcription factor NF-kappa B . |
| Transient short-term expression of the Tax protein of human T-cell leukemia virus type-I ( HTLV-I ) leads to activation of the pleiotropic proteintranscription factor NF-kappa B . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0014 | 20.9333 | 10.8787 | Consistent with findings obtained with transient expression assays , we observed marked accumulation of the transcription factor NF-kappa B in the nucleus of cell_lineNamalwa B lymphoid cells , which constitutively express Tax . |
| 3.8152 | 20.9351 | 10.8046 | Consistent with findings obtained with transient expression assays , we observed marked accumulation of the proteintranscription factor NF-kappa B in the nucleus of Namalwa B lymphoid cells , which constitutively express Tax . |
| 0.8888 | 0.9989 | 1.0000 | Consistent with findings obtained with transient expression assays , we observed marked accumulation of the transcription factor proteinNF-kappa B in the nucleus of Namalwa B lymphoid cells , which constitutively express Tax . |
| 0.7769 | 1.0000 | 1.0000 | Consistent with findings obtained with transient expression assays , we observed marked accumulation of the transcription factor NF-kappa B in the nucleus of Namalwa B lymphoid cells , which constitutively express proteinTax . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7628 | 20.4261 | 10.1911 | In contrast, NF-kappa B activity was not detected in the nucleus following long-term expression of Tax in cell_lineJurkat T lymphocytes . |
| 2.3007 | 20.2261 | 1.0000 | In contrast, proteinNF-kappa B activity was not detected in the nucleus following long-term expression of Tax in Jurkat T lymphocytes . |
| 1.5947 | 10.7797 | 1.0000 | In contrast, NF-kappa B activity was not detected in the nucleus following long-term expression of proteinTax in Jurkat T lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2631 | 20.1481 | 0.9999 | The ability of both mitogens and cytokines to activate NF-kappa B was also blocked in cell_lineJurkat cells constitutively expressing Tax . |
| 1.5614 | 10.8269 | 1.0000 | The ability of both mitogens and cytokines to activate NF-kappa B was also blocked in Jurkat cells constitutively expressing proteinTax . |
| 1.4991 | 10.7916 | 1.0000 | The ability of both mitogens and cytokines to activate proteinNF-kappa B was also blocked in Jurkat cells constitutively expressing Tax . |
| 0.9367 | 1.0000 | 1.0000 | The ability of both mitogens and proteincytokines to activate NF-kappa B was also blocked in Jurkat cells constitutively expressing Tax . |
| 0.7727 | 0.9996 | 1.0000 | The ability of both proteinmitogens and cytokines to activate NF-kappa B was also blocked in Jurkat cells constitutively expressing Tax . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8882 | 20.3935 | 10.5804 | However, the activation of other proteinmitogen-inducible transcription factors , such as Fos and Jun , was unaffected. |
| 1.5750 | 10.2202 | 1.0000 | However, the activation of other mitogen-inducible transcription factors , such as proteinFos and Jun , was unaffected. |
| 0.8978 | 1.0000 | 1.0000 | However, the activation of other mitogen-inducible transcription factors , such as Fos and proteinJun , was unaffected. |
| 0.6985 | 0.9998 | 0.9999 | However, the activation of other mitogen-inducible proteintranscription factors , such as Fos and Jun , was unaffected. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7956 | 10.5419 | 1.0000 | Thus, depending on the cellular environment , the short- and long-term effects of proteinTax expression can be quite different. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7859 | 10.3710 | 1.0000 | Consequently, one function of proteinTax in cells infected with HTLV-I might involve cell-type-specific suppression , as opposed to activation, of distinct signal pathways . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6746 | 10.0002 | 0.9998 | The cell_linecells lines described here should be useful for the delineation of signaling pathways utilized in the selective regulation of gene expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9690 | 1.0000 | 1.0000 | proteinInterferon-gamma and the sexual dimorphism of autoimmunity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9669 | 20.0577 | 1.0000 | The sexual difference in the incidence of proteinautoimmune diseases has remained an enigma for many years. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9282 | 1.0000 | 1.0000 | In the examination of the induction of autoimmunity in transgenic mice , evidence has been obtained further implicating the lymphokine proteininterferon-gamma in the etiology of autoimmunity . |
| 2.4544 | 20.9011 | 1.0000 | In the examination of the induction of autoimmunity in transgenic mice , evidence has been obtained further implicating the proteinlymphokine interferon-gamma in the etiology of autoimmunity . |
| In the examination of the induction of autoimmunity in transgenic mice , evidence has been obtained further implicating the proteinlymphokine interferon-gamma in the etiology of autoimmunity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7663 | 10.5278 | 1.0000 | Sex steroid regulation of the production of this molecule, as well as other proteincytokines , may help explain the gender-specific differences in the immune system , including autoimmunity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9191 | 10.9449 | 10.4913 | Cloning of a transcriptionally active proteinhuman TATA binding factor . |
| Cloning of a proteintranscriptionally active human TATA binding factor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9552 | 30.1712 | 10.7944 | Transcription factor IID ( TFIID ) binds to the TATA box promoter element and regulates the expression of most eukaryotic genes transcribed by proteinRNA polymerase II . |
| 3.7422 | 20.9405 | 10.6650 | Transcription factor IID ( TFIID ) binds to the DNATATA box promoter element and regulates the expression of most eukaryotic genes transcribed by RNA polymerase II . |
| 1.5846 | 0.9981 | 10.3815 | proteinTranscription factor IID ( TFIID ) binds to the TATA box promoter element and regulates the expression of most eukaryotic genes transcribed by RNA polymerase II . |
| 1.1591 | 10.8633 | 0.9999 | Transcription factor IID ( TFIID ) binds to the TATA box promoter element and regulates the expression of most DNAeukaryotic genes transcribed by RNA polymerase II . |
| 0.9714 | 1.0000 | 1.0000 | Transcription factor IID ( proteinTFIID ) binds to the TATA box promoter element and regulates the expression of most eukaryotic genes transcribed by RNA polymerase II . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9765 | 20.3870 | 10.0872 | Complementary DNA ( cDNA ) encoding a proteinhuman TFIID protein has been cloned. |
| 0.9309 | 1.0000 | 1.0000 | Complementary DNA ( DNAcDNA ) encoding a human TFIID protein has been cloned. |
| 0.9165 | 1.0000 | 0.9841 | Complementary DNA ( cDNA ) encoding a human proteinTFIID protein has been cloned. |
| 0.7816 | 0.9988 | 0.9998 | DNAComplementary DNA ( cDNA ) encoding a human TFIID protein has been cloned. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1658 | 10.7866 | 10.2450 | The proteinhuman TFIID polypeptide has 339 amino acids and a molecular size of 37,745 daltons . |
| 0.9429 | 1.0000 | 0.9830 | The human proteinTFIID polypeptide has 339 amino acids and a molecular size of 37,745 daltons . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9277 | 30.2597 | 0.9999 | The carboxyl-terminal 181 amino acids of the proteinhuman TFIID protein shares 80% identity with the TFIID protein from Saccharomyces cerevisiae . |
| 1.7783 | 20.6995 | 0.9865 | The carboxyl-terminal 181 amino acids of the human TFIID protein shares 80% identity with the proteinTFIID protein from Saccharomyces cerevisiae . |
| 1.5470 | 10.4491 | 0.9982 | The proteincarboxyl-terminal 181 amino acids of the human TFIID protein shares 80% identity with the TFIID protein from Saccharomyces cerevisiae . |
| 0.9068 | 1.0000 | 0.9858 | The carboxyl-terminal 181 amino acids of the human proteinTFIID protein shares 80% identity with the TFIID protein from Saccharomyces cerevisiae . |
| 1.8697 | 20.8956 | 1.0000 | The carboxyl-terminal 181 amino acids of the human TFIID protein shares 80% identity with the proteinTFIID protein from Saccharomyces cerevisiae . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2004 | 20.4643 | 0.9999 | The amino terminus contains an unusual repeat of 38 consecutive glutamine residues and an proteinX-Thr-Pro repeat . |
| 0.7347 | 0.9951 | 1.0000 | The proteinamino terminus contains an unusual repeat of 38 consecutive glutamine residues and an X-Thr-Pro repeat . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Expression of DNADNA in reticulocyte lysates or in Escherichia coli yielded a protein that was competent for both DNA binding and transcription activation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4263 | 20.2766 | 10.6660 | A novel T-cell trans-activator that recognizes a DNAphorbol ester-inducible element of the interleukin-2 promoter . |
| 2.5645 | 20.1427 | 10.1068 | A novel proteinT-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter . |
| 1.9565 | 20.1914 | 0.9997 | A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the DNAinterleukin-2 promoter . |
| A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the proteininterleukin-2 promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7176 | 10.4143 | 0.9702 | The DNAinterleukin 2 ( IL-2 ) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and T-cell activation . |
| 1.6149 | 10.0296 | 1.0000 | The interleukin 2 ( IL-2 ) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to proteinIL-2 production and T-cell activation . |
| 0.9721 | 1.0000 | 0.9967 | The interleukin 2 ( proteinIL-2 ) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and T-cell activation . |
| The proteininterleukin 2 ( IL-2 ) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and T-cell activation . | |||
| The interleukin 2 ( IL-2 ) gene promoter is recognized by several cell-type-specific and ubiquitous transcriptional regulators that integrate information transmitted by various signaling systems leading to IL-2 production and cell_typeT-cell activation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6767 | 20.7855 | 10.6643 | Using a combination of transfection , protein-DNA binding, and in vitro transcription methods , we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1 ), which recognizes a DNAT-cell-specific response element ( TCE ) located within the IL-2 promoter . |
| 2.1407 | 20.5072 | 0.9999 | Using a combination of transfection , protein-DNA binding, and in vitro transcription methods , we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1 ), which recognizes a T-cell-specific response element ( TCE ) located within the DNAIL-2 promoter . |
| 1.7199 | 20.4812 | 0.9842 | Using a combination of transfection , protein-DNA binding, and in vitro transcription methods , we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1 ), which recognizes a T-cell-specific response element ( TCE ) located within the proteinIL-2 promoter . |
| 0.9628 | 0.9999 | 1.0000 | Using a combination of transfection , protein-DNA binding, and in vitro transcription methods , we have discovered the novel T-cell-specific transcriptional activator proteinTCF-1 (for T-Cell Factor-1 ), which recognizes a T-cell-specific response element ( TCE ) located within the IL-2 promoter . |
| 0.9505 | 1.0000 | 1.0000 | Using a combination of transfection , protein-DNA binding, and in vitro transcription methods , we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1 ), which recognizes a T-cell-specific response element ( DNATCE ) located within the IL-2 promoter . |
| 0.8314 | 0.9998 | 1.0000 | Using a combination of transfection , protein-DNA binding, and in vitro transcription methods , we have discovered the novel T-cell-specific transcriptional activator TCF-1 (for proteinT-Cell Factor-1 ), which recognizes a T-cell-specific response element ( TCE ) located within the IL-2 promoter . |
| 3.6999 | 20.6830 | 10.9336 | Using a combination of transfection , protein-DNA binding, and in vitro transcription methods , we have discovered the novel proteinT-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1 ), which recognizes a T-cell-specific response element ( TCE ) located within the IL-2 promoter . |
| Using a combination of transfection , protein-DNA binding, and in vitro transcription methods , we have discovered the proteinnovel T-cell-specific transcriptional activator TCF-1 (for T-Cell Factor-1 ), which recognizes a T-cell-specific response element ( TCE ) located within the IL-2 promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.0813 | 20.9216 | 20.6374 | Although the TCE is similar in sequence to a DNAconsensus NF kappa B site , several criteria indicate that TCF-1 is distinct from NF kappa B . |
| 3.2720 | 20.9028 | 10.7388 | Although the TCE is similar in sequence to a consensus NF kappa B site , several criteria indicate that TCF-1 is distinct from proteinNF kappa B . |
| 1.6638 | 10.9682 | 1.0000 | Although the DNATCE is similar in sequence to a consensus NF kappa B site , several criteria indicate that TCF-1 is distinct from NF kappa B . |
| 1.4016 | 1.0000 | 10.5572 | Although the TCE is similar in sequence to a consensus proteinNF kappa B site , several criteria indicate that TCF-1 is distinct from NF kappa B . |
| 0.8193 | 1.0000 | 1.0000 | Although the TCE is similar in sequence to a consensus NF kappa B site , several criteria indicate that proteinTCF-1 is distinct from NF kappa B . |
| 0.5579 | 0.9973 | 0.9979 | Although the TCE is similar in sequence to a consensus DNANF kappa B site , several criteria indicate that TCF-1 is distinct from NF kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4322 | 20.4939 | 10.8061 | However, like proteinNF kappa B , TCF-1 activity is induced by phorbol esters and other T-cell activators . |
| 0.9140 | 1.0000 | 1.0000 | However, like NF kappa B , proteinTCF-1 activity is induced by phorbol esters and other T-cell activators . |
| 1.9231 | 20.2033 | 0.9998 | However, like NF kappa B , TCF-1 activity is induced by phorbol esters and other proteinT-cell activators . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7908 | 10.8815 | 1.0000 | Monofactorial analysis identified the following factors to be correlated with increased risk: moderate/marked mononuclear cell reaction ( MCR ), high histologic grade (G), extensive intraductal component ( EIC ), tumor necrosis , macroscopic multiplicity , proteinestrogen receptor negativity , anatomic tumor size , age younger than 40 years, and vascular invasion . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9737 | 20.6798 | 10.4326 | Tax -independent binding of multiple cellular factors to DNATax -response element DNA of HTLV-I . |
| 1.3554 | 10.3809 | 0.9945 | Tax -independent binding of multiple cellular factors to proteinTax -response element DNA of HTLV-I . |
| 1.2939 | 10.8386 | 0.9996 | Tax -independent binding of multiple proteincellular factors to Tax -response element DNA of HTLV-I . |
| 0.9685 | 1.0000 | 1.0000 | proteinTax -independent binding of multiple cellular factors to Tax -response element DNA of HTLV-I . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5665 | 30.1612 | 10.8286 | The human T-cell leukemia virus type I ( HTLV-I ) promoter contains three copies of imperfect repeats of a 21-base pair sequence designated here as TRE ( DNATax -response element ) that is responsive to the virally encoded transactivator protein Tax . |
| 2.4712 | 10.1042 | 10.1236 | The DNAhuman T-cell leukemia virus type I ( HTLV-I ) promoter contains three copies of imperfect repeats of a 21-base pair sequence designated here as TRE ( Tax -response element ) that is responsive to the virally encoded transactivator protein Tax . |
| 2.1076 | 40.9029 | 10.0160 | The human T-cell leukemia virus type I ( HTLV-I ) promoter contains three copies of imperfect repeats of a 21-base pair sequence designated here as TRE ( Tax -response element ) that is responsive to the proteinvirally encoded transactivator protein Tax . |
| 1.6057 | 10.0379 | 0.9987 | The human T-cell leukemia virus type I ( HTLV-I ) promoter contains three copies of imperfect repeats of a 21-base pair sequence designated here as TRE ( proteinTax -response element ) that is responsive to the virally encoded transactivator protein Tax . |
| 1.5669 | 10.6537 | 1.0000 | The human T-cell leukemia virus type I ( HTLV-I ) promoter contains three copies of imperfect repeats of a 21-base pair sequence designated here as DNATRE ( Tax -response element ) that is responsive to the virally encoded transactivator protein Tax . |
| 0.9593 | 0.9998 | 1.0000 | The human T-cell leukemia virus type I ( HTLV-I ) promoter contains three copies of imperfect repeats of a 21-base pair sequence designated here as TRE ( Tax -response element ) that is responsive to the virally encoded transactivator protein proteinTax . |
| 2.1281 | 20.6393 | 10.9558 | The human T-cell leukemia virus type I ( HTLV-I ) promoter contains three copies of imperfect repeats of a DNA21-base pair sequence designated here as TRE ( Tax -response element ) that is responsive to the virally encoded transactivator protein Tax . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.0864 | 20.8312 | 20.1648 | We have identified and separated four nuclear proteins from C81-66-45 cells, an cell_lineHTLV-I immortalized Tax -expressing human T-lymphocyte line (Salahuddin et al., 1983), that interact with the TRE -DNA , none of which are identical with the Tax -protein . |
| 2.1046 | 20.5265 | 0.9927 | We have identified and separated four nuclear proteins from C81-66-45 cells, an HTLV-I immortalized Tax -expressing human T-lymphocyte line (Salahuddin et al., 1983), that interact with the TRE -DNA , none of which are identical with the proteinTax -protein . |
| 1.9981 | 20.2603 | 0.9941 | We have identified and separated four nuclear proteins from C81-66-45 cells, an HTLV-I immortalized Tax -expressing human T-lymphocyte line (Salahuddin et al., 1983), that interact with the DNATRE -DNA , none of which are identical with the Tax -protein . |
| 1.8874 | 20.0843 | 1.0000 | We have identified and separated four nuclear proteins from C81-66-45 cells, an HTLV-I immortalized Tax -expressing human T-lymphocyte line (Salahuddin et al., 1983), that interact with the DNATRE -DNA , none of which are identical with the Tax -protein . |
| 1.8292 | 20.7799 | 0.9999 | We have identified and separated four nuclear proteins from C81-66-45 cells, an HTLV-I immortalized Tax -expressing human T-lymphocyte line (Salahuddin et al., 1983), that interact with the TRE -DNA , none of which are identical with the proteinTax -protein . |
| 1.3887 | 10.6008 | 0.9999 | We have identified and separated four proteinnuclear proteins from C81-66-45 cells, an HTLV-I immortalized Tax -expressing human T-lymphocyte line (Salahuddin et al., 1983), that interact with the TRE -DNA , none of which are identical with the Tax -protein . |
| 0.9588 | 1.0000 | 0.9985 | We have identified and separated four nuclear proteins from C81-66-45 cells, an HTLV-I immortalized proteinTax -expressing human T-lymphocyte line (Salahuddin et al., 1983), that interact with the TRE -DNA , none of which are identical with the Tax -protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9046 | 20.0891 | 10.9516 | First, from different cell lines three or all four of the nuclear proteins were specifically cross-linked by UV irradiation to the radioactively labeled DNATRE -DNA fragment . |
| 1.5385 | 10.9798 | 1.0000 | First, from different cell lines three or all four of the proteinnuclear proteins were specifically cross-linked by UV irradiation to the radioactively labeled TRE -DNA fragment . |
| 0.8561 | 1.0000 | 0.9955 | First, from different cell lines three or all four of the nuclear proteins were specifically cross-linked by UV irradiation to the radioactively labeled DNATRE -DNA fragment . |
| 2.3434 | 20.1965 | 0.9999 | First, from different cell_linecell lines three or all four of the nuclear proteins were specifically cross-linked by UV irradiation to the radioactively labeled TRE -DNA fragment . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3385 | 10.9552 | 10.5608 | Second, proteinTRE -DNA binding proteins sedimented through a glycerol density gradient at rates corresponding to proteins of native molecular weights of 35 to 50 kD and 110 kD. |
| 0.8207 | 1.0000 | 0.9946 | Second, DNATRE -DNA binding proteins sedimented through a glycerol density gradient at rates corresponding to proteins of native molecular weights of 35 to 50 kD and 110 kD. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8359 | 20.9026 | 10.9201 | Third, only the protein50 kD protein was retained on a biotinylated DNA-streptavidin matrix when the DNA fragment contained the TRE -DNA . |
| 2.1787 | 20.7580 | 0.9875 | Third, only the 50 kD protein was retained on a biotinylated DNA-streptavidin matrix when the DNA fragment contained the DNATRE -DNA . |
| 2.0679 | 20.4933 | 0.9998 | Third, only the 50 kD protein was retained on a biotinylated DNA-streptavidin matrix when the DNA fragment contained the DNATRE -DNA . |
| 1.8449 | 20.2297 | 0.9998 | Third, only the 50 kD protein was retained on a biotinylated DNA-streptavidin matrix when the DNADNA fragment contained the TRE -DNA . |
| 1.5056 | 20.1384 | 0.9999 | Third, only the 50 kD protein was retained on a proteinbiotinylated DNA-streptavidin matrix when the DNA fragment contained the TRE -DNA . |
| 0.7239 | 1.0000 | 1.0000 | Third, only the 50 kD protein was retained on a biotinylated proteinDNA-streptavidin matrix when the DNA fragment contained the TRE -DNA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6973 | 30.1807 | 10.5114 | Fourth, extensive purification by several cycles of TRE -DNA affinity chromatography resulted in the 32 , 36 to 42 and 110 kD proteins and to less extent the protein50 kD factor . |
| 1.8039 | 10.5070 | 1.0000 | Fourth, extensive purification by several cycles of DNATRE -DNA affinity chromatography resulted in the 32 , 36 to 42 and 110 kD proteins and to less extent the 50 kD factor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3910 | 10.3630 | 1.0000 | Two abundant proteins of 75 and 80 kD were competed out by DNApoly[d(I-C)] in all reactions. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5541 | 30.2652 | 10.0017 | The cAMP-response element CRE , TGACGTCA , present in the DNA21 base-pair sequence , appears to be essential for specific protein- TRE -DNA interactions because mutation of the two G 's destroys this complex. |
| 0.9473 | 0.9998 | 0.9996 | The cAMP-response element CRE , TGACGTCA , present in the 21 base-pair sequence , appears to be essential for specific protein- DNATRE -DNA interactions because mutation of the two G 's destroys this complex. |
| 0.6788 | 0.9995 | 1.0000 | The cAMP-response element DNACRE , TGACGTCA , present in the 21 base-pair sequence , appears to be essential for specific protein- TRE -DNA interactions because mutation of the two G 's destroys this complex. |
| 2.4299 | 10.4251 | 10.1820 | The DNAcAMP-response element CRE , TGACGTCA , present in the 21 base-pair sequence , appears to be essential for specific protein- TRE -DNA interactions because mutation of the two G 's destroys this complex. |
| 0.7507 | 0.9995 | 1.0000 | The cAMP-response element CRE , TGACGTCA , present in the 21 base-pair sequence , appears to be essential for specific protein- TRE -DNA interactions because mutation of the two DNAG 's destroys this complex. |
| 0.6103 | 0.9999 | 0.9676 | The cAMP-response element CRE , TGACGTCA , present in the 21 base-pair sequence , appears to be essential for specific protein- TRE -DNA interactions because mutation of the two DNAG 's destroys this complex. |
| 0.5595 | 0.9982 | 0.9999 | The cAMP-response element CRE , TGACGTCA , present in the 21 base-pair sequence , appears to be essential for specific protein- DNATRE -DNA interactions because mutation of the two G 's destroys this complex. |
| The DNAcAMP-response element CRE , TGACGTCA , present in the 21 base-pair sequence , appears to be essential for specific protein- TRE -DNA interactions because mutation of the two G 's destroys this complex. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.2567 | 30.6748 | 10.9626 | This result suggests that the proteincAMP response element binding protein , CREB , is involved in the protein- TRE -DNA complex and in mediating the Tax response . |
| 4.1960 | 30.3306 | 10.8652 | This result suggests that the cAMP response element binding protein , CREB , is involved in the proteinprotein- TRE -DNA complex and in mediating the Tax response . |
| 1.5531 | 10.2064 | 1.0000 | This result suggests that the cAMP response element binding protein , CREB , is involved in the protein- TRE -DNA complex and in mediating the proteinTax response . |
| 0.9226 | 1.0000 | 1.0000 | This result suggests that the cAMP response element binding protein , proteinCREB , is involved in the protein- TRE -DNA complex and in mediating the Tax response . |
| 0.8452 | 1.0000 | 0.9858 | This result suggests that the cAMP response element binding protein , CREB , is involved in the protein- DNATRE -DNA complex and in mediating the Tax response . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6849 | 20.3441 | 0.9999 | Two distinct proteintranscription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif . |
| 1.5338 | 20.6831 | 0.9821 | Two distinct transcription factors that bind the DNAimmunoglobulin enhancer microE5/kappa 2 motif . |
| 4.4562 | 20.9947 | 10.8451 | Two distinct transcription factors that bind the DNAimmunoglobulin enhancer microE5/kappa 2 motif . |
| Two distinct transcription factors that bind the immunoglobulin enhancer DNAmicroE5/kappa 2 motif . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.7718 | 20.9783 | 20.8099 | Activity of the DNAimmunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins . |
| Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of proteinubiquitous and developmentally regulated proteins . | |||
| Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and proteindevelopmentally regulated proteins . | |||
| Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of proteinubiquitous and developmentally regulated proteins . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8702 | 20.8606 | 10.6135 | Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2 , that are expressed in a variety of cell types and bind the DNAmicroE5/kappa 2 motif found in both heavy and kappa light chain enhancers . |
| 1.6169 | 10.9062 | 1.0000 | Two DNAcomplementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2 , that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers . |
| 0.9696 | 1.0000 | 1.0000 | Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and proteinITF-2 , that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers . |
| 0.8913 | 1.0000 | 1.0000 | Two complementary DNAs were isolated that encode proteins, denoted proteinITF-1 and ITF-2 , that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6968 | 10.5196 | 1.0000 | The DNAcomplementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. |
| 1.6796 | 10.3886 | 1.0000 | The complementary DNAs are the products of distinct genes, yet both proteinITF-1 and ITF-2 are structurally and functionally similar. |
| 0.9281 | 1.0000 | 1.0000 | The complementary DNAs are the products of distinct genes, yet both ITF-1 and proteinITF-2 are structurally and functionally similar. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4511 | 20.0589 | 1.0000 | The two proteins interact with one another through their putative proteinhelix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7047 | 20.4423 | 10.6416 | Elevated glucocorticoid receptor concentrations before and after glucocorticoid therapy in cell_typeperipheral mononuclear leukocytes of patients with atopic dermatitis . |
| 1.5099 | 10.5981 | 1.0000 | Elevated proteinglucocorticoid receptor concentrations before and after glucocorticoid therapy in peripheral mononuclear leukocytes of patients with atopic dermatitis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0403 | 20.2013 | 10.3074 | The number and affinity of glucocorticoid binding sites in cell_typeperipheral mononuclear leukocytes of patients with atopic dermatitis ( AD ) and healthy controls were determined under baseline conditions and after a defined oral glucocorticoid treatment . |
| 3.8912 | 20.7805 | 10.7463 | The number and affinity of proteinglucocorticoid binding sites in peripheral mononuclear leukocytes of patients with atopic dermatitis ( AD ) and healthy controls were determined under baseline conditions and after a defined oral glucocorticoid treatment . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6402 | 10.9459 | 1.0000 | Patients with AD (n = 15) exhibited significantly more proteinglucocorticoid receptors ( GR ) per cell than the control group (n = 22), while the GR affinity did not differ. |
| 0.9757 | 1.0000 | 1.0000 | Patients with AD (n = 15) exhibited significantly more glucocorticoid receptors ( proteinGR ) per cell than the control group (n = 22), while the GR affinity did not differ. |
| 0.9503 | 1.0000 | 1.0000 | Patients with AD (n = 15) exhibited significantly more glucocorticoid receptors ( GR ) per cell than the control group (n = 22), while the proteinGR affinity did not differ. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4456 | 20.6212 | 0.9948 | Methylprednisolone treatment resulted in a significant reduction of the proteinGR sites per cell in the steroid-treated control group (n = 10) in contrast to the patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9762 | 1.0000 | 1.0000 | In view of the therapeutic efficiency of glucocorticoids in AD and findings of abnormal cAMP and cAMP-phosphodiesterase activity , the elevated GR concentrations in AD lend support to the hypothesis of a compensatory GR upregulation due to an insufficient action of endogenous cortisol or to altered cAMP -induced proteinGR expression . |
| 0.9586 | 1.0000 | 1.0000 | In view of the therapeutic efficiency of glucocorticoids in AD and findings of abnormal cAMP and cAMP-phosphodiesterase activity , the elevated GR concentrations in AD lend support to the hypothesis of a compensatory proteinGR upregulation due to an insufficient action of endogenous cortisol or to altered cAMP -induced GR expression . |
| 0.9577 | 1.0000 | 1.0000 | In view of the therapeutic efficiency of glucocorticoids in AD and findings of abnormal cAMP and cAMP-phosphodiesterase activity , the elevated proteinGR concentrations in AD lend support to the hypothesis of a compensatory GR upregulation due to an insufficient action of endogenous cortisol or to altered cAMP -induced GR expression . |
| 0.9035 | 1.0000 | 1.0000 | In view of the therapeutic efficiency of glucocorticoids in AD and findings of abnormal cAMP and proteincAMP-phosphodiesterase activity , the elevated GR concentrations in AD lend support to the hypothesis of a compensatory GR upregulation due to an insufficient action of endogenous cortisol or to altered cAMP -induced GR expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5125 | 20.5353 | 0.9999 | The actions of cyclosporin A and FK506 suggest a novel step in the activation of cell_typeT lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7097 | 10.5844 | 1.0000 | Cyclosporin A and FK506 are immunosuppressive compounds that have similar inhibitory effects on the expression of several proteinlymphokines produced by T lymphocytes . |
| 1.5757 | 10.5693 | 0.9998 | Cyclosporin A and FK506 are immunosuppressive compounds that have similar inhibitory effects on the expression of several lymphokines produced by cell_typeT lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3518 | 20.4657 | 1.0000 | Despite their similar effects the drugs bind to two different proteincytosolic protein , cyclophilin and FKBP respectively, which raises the possibility that they have different modes of action. |
| 0.9605 | 1.0000 | 1.0000 | Despite their similar effects the drugs bind to two different cytosolic protein , cyclophilin and proteinFKBP respectively, which raises the possibility that they have different modes of action. |
| 0.9591 | 1.0000 | 1.0000 | Despite their similar effects the drugs bind to two different cytosolic protein , proteincyclophilin and FKBP respectively, which raises the possibility that they have different modes of action. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8328 | 20.9254 | 10.5462 | Using constructs in which mRNA production controlled by a specific transcription factor could be readily measured we found that both cyclosporin A and FK506 completely inhibited transcription activated by NF-AT , NFIL2 A , NFIL2 B and partially inhibited transcription activated by proteinNF kappa B . |
| 2.3239 | 20.0452 | 1.0000 | Using constructs in which mRNA production controlled by a specific proteintranscription factor could be readily measured we found that both cyclosporin A and FK506 completely inhibited transcription activated by NF-AT , NFIL2 A , NFIL2 B and partially inhibited transcription activated by NF kappa B . |
| 1.6724 | 10.6730 | 1.0000 | Using constructs in which mRNA production controlled by a specific transcription factor could be readily measured we found that both cyclosporin A and FK506 completely inhibited transcription activated by NF-AT , NFIL2 A , proteinNFIL2 B and partially inhibited transcription activated by NF kappa B . |
| 1.6705 | 10.6657 | 1.0000 | Using constructs in which mRNA production controlled by a specific transcription factor could be readily measured we found that both cyclosporin A and FK506 completely inhibited transcription activated by NF-AT , proteinNFIL2 A , NFIL2 B and partially inhibited transcription activated by NF kappa B . |
| 1.5506 | 10.1423 | 1.0000 | Using constructs in which RNAmRNA production controlled by a specific transcription factor could be readily measured we found that both cyclosporin A and FK506 completely inhibited transcription activated by NF-AT , NFIL2 A , NFIL2 B and partially inhibited transcription activated by NF kappa B . |
| 0.8878 | 0.9998 | 1.0000 | Using constructs in which mRNA production controlled by a specific transcription factor could be readily measured we found that both cyclosporin A and FK506 completely inhibited transcription activated by proteinNF-AT , NFIL2 A , NFIL2 B and partially inhibited transcription activated by NF kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5800 | 20.2922 | 1.0000 | However, cyclosporin A and FK506 did not inhibit Ca2+ mobilization dependent expression of RNAc-fos mRNA indicating that only a subset of signalling pathways regulated by Ca2+ is sensitive to these drugs. |
| 1.8444 | 20.5317 | 0.9905 | However, cyclosporin A and FK506 did not inhibit Ca2+ mobilization dependent expression of DNAc-fos mRNA indicating that only a subset of signalling pathways regulated by Ca2+ is sensitive to these drugs. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5760 | 20.5608 | 1.0000 | Furthermore, we did not observe any qualitative differences between the effect of cyclosporin A and FK506 on six different transcription factors which suggests that these drugs may interfere with the activity of a novel Ca2+ dependent step that regulates several proteintranscription factors . |
| 2.5725 | 20.2346 | 1.0000 | Furthermore, we did not observe any qualitative differences between the effect of cyclosporin A and FK506 on six different proteintranscription factors which suggests that these drugs may interfere with the activity of a novel Ca2+ dependent step that regulates several transcription factors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.0057 | 20.4862 | 20.7367 | The internal methionine codons of DNAhuman T-cell leukemia virus type II rex gene are not required for p24rex production or virus replication and transformation . |
| 0.7808 | 1.0000 | 1.0000 | The internal methionine codons of human T-cell leukemia virus type II rex gene are not required for proteinp24rex production or virus replication and transformation . |
| 1.0890 | 10.2612 | 0.9886 | The DNAinternal methionine codons of human T-cell leukemia virus type II rex gene are not required for p24rex production or virus replication and transformation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7823 | 20.8695 | 10.5586 | Human T-cell leukemia virus types I ( HTLV-I ) and II ( HTLV-II ) have two DNAnonstructural trans-acting regulatory genes , tax and rex , located in the 3' region of the viral genome . |
| 2.1962 | 20.2474 | 0.9998 | Human T-cell leukemia virus types I ( HTLV-I ) and II ( HTLV-II ) have two nonstructural trans-acting regulatory genes , tax and rex , located in the 3' region of the DNAviral genome . |
| 2.1737 | 20.4543 | 0.9999 | Human T-cell leukemia virus types I ( HTLV-I ) and II ( HTLV-II ) have two nonstructural trans-acting regulatory genes , tax and rex , located in the DNA3' region of the viral genome . |
| 0.9465 | 1.0000 | 1.0000 | Human T-cell leukemia virus types I ( HTLV-I ) and II ( HTLV-II ) have two nonstructural trans-acting regulatory genes , tax and DNArex , located in the 3' region of the viral genome . |
| 0.9336 | 1.0000 | 1.0000 | Human T-cell leukemia virus types I ( HTLV-I ) and II ( HTLV-II ) have two nonstructural trans-acting regulatory genes , DNAtax and rex , located in the 3' region of the viral genome . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8012 | 20.5404 | 10.5279 | The tax gene product ( HTLV-I p40tax and HTLV-II p37tax ) is the transcriptional activator of the DNAviral long terminal repeat . |
| 2.6887 | 10.6867 | 10.7949 | The proteintax gene product ( HTLV-I p40tax and HTLV-II p37tax ) is the transcriptional activator of the viral long terminal repeat . |
| 1.5257 | 10.4371 | 1.0000 | The tax gene product ( proteinHTLV-I p40tax and HTLV-II p37tax ) is the transcriptional activator of the viral long terminal repeat . |
| 1.2025 | 10.0601 | 1.0000 | The tax gene product ( HTLV-I p40tax and proteinHTLV-II p37tax ) is the transcriptional activator of the viral long terminal repeat . |
| 1.9455 | 20.1179 | 1.0000 | The tax gene product ( HTLV-I p40tax and HTLV-II p37tax ) is the proteintranscriptional activator of the viral long terminal repeat . |
| 0.8349 | 1.0000 | 1.0000 | The tax gene product ( HTLV-I p40tax and HTLV-II proteinp37tax ) is the transcriptional activator of the viral long terminal repeat . |
| 0.6935 | 1.0000 | 1.0000 | The tax gene product ( HTLV-I proteinp40tax and HTLV-II p37tax ) is the transcriptional activator of the viral long terminal repeat . |
| The tax gene product ( HTLV-I DNAp40tax and HTLV-II p37tax ) is the transcriptional activator of the viral long terminal repeat . | |||
| The tax gene product ( HTLV-I p40tax and HTLV-II DNAp37tax ) is the transcriptional activator of the viral long terminal repeat . | |||
| The DNAtax gene product ( HTLV-I p40tax and HTLV-II p37tax ) is the transcriptional activator of the viral long terminal repeat . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7687 | 10.3740 | 1.0000 | The rex gene encodes two protein products, p27rex /p21rex and proteinp26rex /p24rex in HTLV-I and HTLV-II , respectively. |
| 1.5966 | 10.3129 | 1.0000 | The DNArex gene encodes two protein products, p27rex /p21rex and p26rex /p24rex in HTLV-I and HTLV-II , respectively. |
| 1.1732 | 10.5009 | 0.9909 | The rex gene encodes two protein products, p27rex /p21rex and proteinp26rex /p24rex in HTLV-I and HTLV-II , respectively. |
| 0.9135 | 0.9995 | 1.0000 | The rex gene encodes two protein products, proteinp27rex /p21rex and p26rex /p24rex in HTLV-I and HTLV-II , respectively. |
| 0.7495 | 1.0000 | 1.0000 | The rex gene encodes two protein products, p27rex /p21rex and p26rex protein/p24rex in HTLV-I and HTLV-II , respectively. |
| 0.6938 | 0.9998 | 0.9893 | The rex gene encodes two protein products, proteinp27rex /p21rex and p26rex /p24rex in HTLV-I and HTLV-II , respectively. |
| 0.6515 | 1.0000 | 1.0000 | The rex gene encodes two protein products, p27rex protein/p21rex and p26rex /p24rex in HTLV-I and HTLV-II , respectively. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5675 | 10.9506 | 0.9999 | Rex acts posttranscriptionally to facilitate accumulation of full-length gag/pol and singly spliced RNAenv mRNA in the cytoplasm of HTLV-infected cells . |
| 1.5166 | 10.8354 | 0.9997 | Rex acts posttranscriptionally to facilitate accumulation of full-length gag/pol and singly spliced env mRNA in the cytoplasm of cell_typeHTLV-infected cells . |
| 0.9706 | 1.0000 | 1.0000 | proteinRex acts posttranscriptionally to facilitate accumulation of full-length gag/pol and singly spliced env mRNA in the cytoplasm of HTLV-infected cells . |
| Rex acts posttranscriptionally to facilitate accumulation of full-length proteingag/pol and singly spliced env mRNA in the cytoplasm of HTLV-infected cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2685 | 20.1070 | 1.0000 | Previous studies showed that the first ATG of the DNArex gene is critical for Rex production and function. |
| 1.7678 | 10.1719 | 1.0000 | Previous studies showed that the first ATG of the rex gene is critical for proteinRex production and function. |
| Previous studies showed that the first ATG of the DNArex gene is critical for Rex production and function. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8833 | 1.0000 | 1.0000 | The importance of the internal ATGs to proteinRex function is not known. |
| 0.9246 | 1.0000 | 1.0000 | The importance of the internal DNAATGs to Rex function is not known. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5161 | 20.7281 | 10.7299 | However, in vitro mutagenesis of the HTLV-I rex gene has provided indirect evidence which suggests that p21rex , and by analogy HTLV-II p24rex , results from initiation at an internal AUG of the RNAtax /rex mRNA . |
| 1.7275 | 10.1019 | 1.0000 | However, in vitro mutagenesis of the HTLV-I rex gene has provided indirect evidence which suggests that proteinp21rex , and by analogy HTLV-II p24rex , results from initiation at an internal AUG of the tax /rex mRNA . |
| 0.9333 | 1.0000 | 1.0000 | However, in vitro mutagenesis of the HTLV-I rex gene has provided indirect evidence which suggests that p21rex , and by analogy HTLV-II proteinp24rex , results from initiation at an internal AUG of the tax /rex mRNA . |
| 3.9097 | 20.5705 | 10.9377 | However, in vitro mutagenesis of the DNAHTLV-I rex gene has provided indirect evidence which suggests that p21rex , and by analogy HTLV-II p24rex , results from initiation at an internal AUG of the tax /rex mRNA . |
| 1.4380 | 10.6762 | 1.0000 | However, in vitro mutagenesis of the HTLV-I rex gene has provided indirect evidence which suggests that p21rex , and by analogy proteinHTLV-II p24rex , results from initiation at an internal AUG of the tax /rex mRNA . |
| However, in vitro mutagenesis of the HTLV-I rex gene has provided indirect evidence which suggests that p21rex , and by analogy HTLV-II p24rex , results from initiation at an internal AUG of the DNAtax /rex mRNA . | |||
| However, in vitro mutagenesis of the HTLV-I DNArex gene has provided indirect evidence which suggests that p21rex , and by analogy HTLV-II p24rex , results from initiation at an internal AUG of the tax /rex mRNA . | |||
| However, in vitro mutagenesis of the HTLV-I rex gene has provided indirect evidence which suggests that p21rex , and by analogy HTLV-II p24rex , results from initiation at an internal AUG of the tax DNA/rex mRNA . | |||
| However, in vitro mutagenesis of the HTLV-I DNArex gene has provided indirect evidence which suggests that p21rex , and by analogy HTLV-II p24rex , results from initiation at an internal AUG of the tax /rex mRNA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5814 | 10.6901 | 0.9999 | By using an infectious molecular clone of HTLV-II , we investigated the importance of the internal ATGs of the DNArex gene on Rex protein production and function. |
| 1.3080 | 10.9795 | 0.9907 | By using an infectious molecular clone of HTLV-II , we investigated the importance of the internal ATGs of the rex gene on proteinRex protein production and function. |
| 1.6781 | 10.5505 | 1.0000 | By using an infectious molecular clone of HTLV-II , we investigated the importance of the internal ATGs of the rex gene on proteinRex protein production and function. |
| 1.1736 | 10.9797 | 0.9999 | By using an infectious molecular clone of HTLV-II , we investigated the importance of the DNAinternal ATGs of the rex gene on Rex protein production and function. |
| By using an infectious molecular clone of HTLV-II , we investigated the importance of the internal ATGs of the DNArex gene on Rex protein production and function. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2953 | 20.9059 | 0.9999 | Our results indicate that p24rex of HTLV-II is not initiated at an internal AUG and that the internal methionine codons are not crucial to the function of the DNArex gene and, ultimately, the transforming properties of the virus . |
| 1.7122 | 10.5252 | 1.0000 | Our results indicate that proteinp24rex of HTLV-II is not initiated at an internal AUG and that the internal methionine codons are not crucial to the function of the rex gene and, ultimately, the transforming properties of the virus . |
| 3.8241 | 20.8125 | 10.6536 | Our results indicate that p24rex of HTLV-II is not initiated at an internal AUG and that the DNAinternal methionine codons are not crucial to the function of the rex gene and, ultimately, the transforming properties of the virus . |
| 1.8748 | 20.2928 | 1.0000 | Our results indicate that p24rex of HTLV-II is not initiated at an DNAinternal AUG and that the internal methionine codons are not crucial to the function of the rex gene and, ultimately, the transforming properties of the virus . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7625 | 20.6839 | 10.9144 | Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and proteinB cell type Oct-2 proteins . |
| 4.1235 | 20.5560 | 10.8125 | Astrocytes and glioblastoma cells express novel proteinoctamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins . |
| 2.5963 | 10.7137 | 10.9792 | Astrocytes and cell_typeglioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins . |
| 1.2887 | 10.8532 | 0.9997 | Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the proteinubiquitous Oct-1 and B cell type Oct-2 proteins . |
| 0.9125 | 1.0000 | 0.9998 | cell_typeAstrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type Oct-2 proteins . |
| 0.7662 | 1.0000 | 0.9999 | Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous proteinOct-1 and B cell type Oct-2 proteins . |
| 0.7353 | 1.0000 | 0.9103 | Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type proteinOct-2 proteins . |
| 0.6495 | 0.9927 | 0.9996 | Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the ubiquitous Oct-1 and B cell type proteinOct-2 proteins . |
| Astrocytes and glioblastoma cells express novel octamer-DNA binding proteins distinct from the proteinubiquitous Oct-1 and B cell type Oct-2 proteins . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2788 | 20.6239 | 1.0000 | The 'octamer' sequence , ATGCAAAT or its complement ATTTGCAT , is a key element for the transcriptional regulation of DNAimmunoglobulin genes in B-lymphocytes as well as a number of housekeeping genes in all cell types. |
| 2.2358 | 20.2942 | 1.0000 | The 'octamer' sequence , ATGCAAAT or its complement ATTTGCAT , is a key element for the transcriptional regulation of immunoglobulin genes in B-lymphocytes as well as a number of DNAhousekeeping genes in all cell types. |
| 1.5635 | 10.8696 | 1.0000 | The DNA'octamer' sequence , ATGCAAAT or its complement ATTTGCAT , is a key element for the transcriptional regulation of immunoglobulin genes in B-lymphocytes as well as a number of housekeeping genes in all cell types. |
| 0.8858 | 1.0000 | 1.0000 | The 'octamer' sequence , ATGCAAAT or its complement ATTTGCAT , is a key element for the transcriptional regulation of immunoglobulin genes in cell_typeB-lymphocytes as well as a number of housekeeping genes in all cell types. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2530 | 20.4144 | 1.0000 | In lymphocytes , the octamer-binding protein Oct-2A and variants thereof are thought to contribute to the B-cell specific gene expression , while the ubiquitous protein Oct-1 seems to control general DNAoctamer site -dependent transcription . |
| 2.1285 | 20.9703 | 0.9956 | In lymphocytes , the proteinoctamer-binding protein Oct-2A and variants thereof are thought to contribute to the B-cell specific gene expression , while the ubiquitous protein Oct-1 seems to control general octamer site -dependent transcription . |
| 1.8137 | 10.0889 | 1.0000 | In cell_typelymphocytes , the octamer-binding protein Oct-2A and variants thereof are thought to contribute to the B-cell specific gene expression , while the ubiquitous protein Oct-1 seems to control general octamer site -dependent transcription . |
| 0.9893 | 1.0000 | 1.0000 | In lymphocytes , the octamer-binding protein proteinOct-2A and variants thereof are thought to contribute to the B-cell specific gene expression , while the ubiquitous protein Oct-1 seems to control general octamer site -dependent transcription . |
| 2.0264 | 20.9490 | 0.9950 | In lymphocytes , the octamer-binding protein Oct-2A and variants thereof are thought to contribute to the B-cell specific gene expression , while the proteinubiquitous protein Oct-1 seems to control general octamer site -dependent transcription . |
| 0.9896 | 1.0000 | 1.0000 | In lymphocytes , the octamer-binding protein Oct-2A and variants thereof are thought to contribute to the B-cell specific gene expression , while the ubiquitous protein proteinOct-1 seems to control general octamer site -dependent transcription . |
| In lymphocytes , the octamer-binding protein Oct-2A and variants thereof are thought to contribute to the DNAB-cell specific gene expression , while the ubiquitous protein Oct-1 seems to control general octamer site -dependent transcription . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4698 | 10.9537 | 0.9999 | Various other genes, for example interleukin-1 and MHC class II genes , contain an DNAoctamer sequence in the promoter and are expressed in cells of both the immune and nervous systems . |
| 0.8775 | 1.0000 | 1.0000 | Various other genes, for example interleukin-1 and MHC class II genes , contain an octamer sequence in the DNApromoter and are expressed in cells of both the immune and nervous systems . |
| 4.1746 | 20.7324 | 10.8440 | Various other genes, for example interleukin-1 and DNAMHC class II genes , contain an octamer sequence in the promoter and are expressed in cells of both the immune and nervous systems . |
| 1.5404 | 10.0586 | 1.0000 | Various other genes, for example proteininterleukin-1 and MHC class II genes , contain an octamer sequence in the promoter and are expressed in cells of both the immune and nervous systems . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4985 | 10.9739 | 1.0000 | This prompted us to analyze the proteinoctamer-binding proteins in the latter cells. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5826 | 20.6162 | 10.8564 | Using the electrophoretic mobility shift assay , at least six novel proteinoctamer binding proteins were detected in nuclear extracts of cultured mouse astrocytes . |
| 3.3373 | 20.9723 | 10.7424 | Using the electrophoretic mobility shift assay , at least six novel octamer binding proteins were detected in nuclear extracts of cell_linecultured mouse astrocytes . |
| 0.6734 | 0.9999 | 0.9999 | Using the electrophoretic mobility shift assay , at least six novel octamer binding proteins were detected in nuclear extracts of cultured mouse cell_typeastrocytes . |
| Using the electrophoretic mobility shift assay , at least six novel octamer binding proteins were detected in nuclear extracts of cell_typecultured mouse astrocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9939 | 10.8378 | 10.7455 | These proteins are differentially expressed in human glioblastoma and cell_lineneuroblastoma cell lines . |
| 1.3955 | 10.7987 | 0.9996 | These proteins are differentially expressed in cell_linehuman glioblastoma and neuroblastoma cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2900 | 20.9047 | 10.2597 | The nervous system-derived (N-Oct) proteins bound to the DNAoctamer DNA sequence in a manner which is indistinguishable from the Oct-1 and Oct-2A proteins . |
| 1.5471 | 10.3148 | 0.9981 | The proteinnervous system-derived (N-Oct) proteins bound to the octamer DNA sequence in a manner which is indistinguishable from the Oct-1 and Oct-2A proteins . |
| 1.4102 | 10.9422 | 1.0000 | The nervous system-derived (N-Oct) proteins bound to the octamer DNA sequence in a manner which is indistinguishable from the proteinOct-1 and Oct-2A proteins . |
| 1.4019 | 10.9688 | 0.9999 | The nervous system-derived (N-Oct) proteins bound to the octamer DNA sequence in a manner which is indistinguishable from the Oct-1 and proteinOct-2A proteins . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5419 | 10.8716 | 1.0000 | The relationship of the proteinN-Oct proteins to Oct-1 and Oct-2A was analyzed by proteolytic clipping bandshift assays and by their reactivity towards antisera raised against recombinant Oct-1 and Oct-2A proteins. |
| 0.9797 | 1.0000 | 1.0000 | The relationship of the N-Oct proteins to Oct-1 and Oct-2A was analyzed by proteolytic clipping bandshift assays and by their reactivity towards antisera raised against recombinant proteinOct-1 and Oct-2A proteins. |
| 0.9626 | 1.0000 | 1.0000 | The relationship of the N-Oct proteins to Oct-1 and proteinOct-2A was analyzed by proteolytic clipping bandshift assays and by their reactivity towards antisera raised against recombinant Oct-1 and Oct-2A proteins. |
| 0.8791 | 1.0000 | 1.0000 | The relationship of the N-Oct proteins to proteinOct-1 and Oct-2A was analyzed by proteolytic clipping bandshift assays and by their reactivity towards antisera raised against recombinant Oct-1 and Oct-2A proteins. |
| 1.3100 | 10.9470 | 0.9999 | The relationship of the N-Oct proteins to Oct-1 and Oct-2A was analyzed by proteolytic clipping bandshift assays and by their reactivity towards antisera raised against proteinrecombinant Oct-1 and Oct-2A proteins. |
| The relationship of the N-Oct proteins to Oct-1 and Oct-2A was analyzed by proteolytic clipping bandshift assays and by their reactivity towards antisera raised against recombinant Oct-1 and proteinOct-2A proteins. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3979 | 10.4724 | 1.0000 | On the basis of these assays, all proteinN-Oct-factors were found to be distinct from the ubiquitous Oct-1 and the lymphoid-specific Oct-2A proteins. |
| 1.2466 | 10.8645 | 0.9999 | On the basis of these assays, all N-Oct-factors were found to be distinct from the proteinubiquitous Oct-1 and the lymphoid-specific Oct-2A proteins. |
| 0.9579 | 1.0000 | 1.0000 | On the basis of these assays, all N-Oct-factors were found to be distinct from the ubiquitous proteinOct-1 and the lymphoid-specific Oct-2A proteins. |
| 0.9432 | 1.0000 | 0.9995 | On the basis of these assays, all N-Oct-factors were found to be distinct from the ubiquitous Oct-1 and the lymphoid-specific proteinOct-2A proteins. |
| On the basis of these assays, all N-Oct-factors were found to be distinct from the ubiquitous Oct-1 and the proteinlymphoid-specific Oct-2A proteins. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0052 | 20.4937 | 10.8961 | In melanoma cells that contain the N-Oct-3 factor , a transfected lymphocyte-specific promoter was neither activated nor was it repressed upon contransfection with an DNAOct-2A expression vector . |
| 2.1905 | 20.3459 | 1.0000 | In melanoma cells that contain the proteinN-Oct-3 factor , a transfected lymphocyte-specific promoter was neither activated nor was it repressed upon contransfection with an Oct-2A expression vector . |
| 1.5379 | 10.5261 | 0.9998 | In cell_typemelanoma cells that contain the N-Oct-3 factor , a transfected lymphocyte-specific promoter was neither activated nor was it repressed upon contransfection with an Oct-2A expression vector . |
| 1.4713 | 10.3336 | 0.9970 | In melanoma cells that contain the N-Oct-3 factor , a transfected lymphocyte-specific promoter was neither activated nor was it repressed upon contransfection with an proteinOct-2A expression vector . |
| 2.1425 | 20.0849 | 0.9999 | In melanoma cells that contain the N-Oct-3 factor , a transfected DNAlymphocyte-specific promoter was neither activated nor was it repressed upon contransfection with an Oct-2A expression vector . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7677 | 10.5091 | 1.0000 | We therefore speculate that proteinN-Oct-3 and other N-Oct factors have a specific role in gene expression in cells of the nervous system . |
| 1.6225 | 10.6284 | 1.0000 | We therefore speculate that N-Oct-3 and other proteinN-Oct factors have a specific role in gene expression in cells of the nervous system . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6015 | 30.2602 | 10.8239 | Detection in non-erythroid cells of a factor with the binding characteristics of the proteinerythroid cell transcription factor EF1 . |
| 1.9000 | 20.4452 | 0.9998 | Detection in cell_typenon-erythroid cells of a factor with the binding characteristics of the erythroid cell transcription factor EF1 . |
| 0.9633 | 0.9999 | 1.0000 | Detection in non-erythroid cells of a factor with the binding characteristics of the erythroid cell transcription factor proteinEF1 . |
| 1.2327 | 0.9997 | 10.3808 | Detection in non-erythroid cells of a factor with the binding characteristics of the erythroid cell proteintranscription factor EF1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9244 | 10.4086 | 10.5779 | The proteinerythroid transcription factor erythroid factor-1 ( EF1 ) plays a critical role in the transcription of erythroid-specific genes . |
| 2.0571 | 20.8029 | 0.9999 | The erythroid transcription factor erythroid factor-1 ( EF1 ) plays a critical role in the transcription of DNAerythroid-specific genes . |
| 0.9819 | 1.0000 | 1.0000 | The erythroid transcription factor erythroid factor-1 ( proteinEF1 ) plays a critical role in the transcription of erythroid-specific genes . |
| 0.8646 | 0.9966 | 0.9998 | The erythroid transcription factor proteinerythroid factor-1 ( EF1 ) plays a critical role in the transcription of erythroid-specific genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7759 | 20.8554 | 10.6445 | Here we report the presence of a factor with the mobility and sequence-specific DNA-binding characteristics of EF1 at low abundance in a wide variety of cell_typenon-erythroid cell types . |
| 1.6153 | 10.5447 | 1.0000 | Here we report the presence of a factor with the mobility and sequence-specific DNA-binding characteristics of proteinEF1 at low abundance in a wide variety of non-erythroid cell types . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4070 | 20.2749 | 1.0000 | This is the first report of an EF1 -like activity in cell_typenon-erythroid cells and indicates that this factor may play a role in the regulation of genes expressed in such cells. |
| 1.7363 | 10.1676 | 1.0000 | This is the first report of an proteinEF1 -like activity in non-erythroid cells and indicates that this factor may play a role in the regulation of genes expressed in such cells. |
| 1.5322 | 10.2171 | 1.0000 | This is the first report of an EF1 -like activity in non-erythroid cells and indicates that this factor may play a role in the regulation of DNAgenes expressed in such cells. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4521 | 20.0352 | 1.0000 | Protein kinase inhibitor H-7 blocks accumulation of RNAunspliced mRNA of human T-cell leukemia virus type I ( HTLV-I ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3145 | 20.9153 | 10.5004 | Rex , the post-transcriptional regulator of human T-cell leukemia virus type I ( HTLV-I ), is known to induce accumulation of the RNAunspliced viral gag-pol mRNA . |
| 2.2395 | 20.6459 | 1.0000 | Rex , the proteinpost-transcriptional regulator of human T-cell leukemia virus type I ( HTLV-I ), is known to induce accumulation of the unspliced viral gag-pol mRNA . |
| 0.9431 | 1.0000 | 1.0000 | proteinRex , the post-transcriptional regulator of human T-cell leukemia virus type I ( HTLV-I ), is known to induce accumulation of the unspliced viral gag-pol mRNA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8104 | 10.4607 | 1.0000 | Rex is a proteinphosphoprotein found in the cell nucleolus , whose function may be regulated by its localization and phosphorylation . |
| 0.9869 | 1.0000 | 1.0000 | proteinRex is a phosphoprotein found in the cell nucleolus , whose function may be regulated by its localization and phosphorylation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7365 | 10.7662 | 1.0000 | We have examined the role of phosphorylation on proteinRex function by using a protein kinase inhibitor , H-7 [ 1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine ]. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.5956 | 30.5101 | 20.9472 | Treatment of an cell_lineHTLV-I infected human T-cell line with H-7 blocked specifically accumulation of the unspliced gag-pol mRNA , resulting in the decreased Gag protein synthesis that corresponds with the decreased in vivo phosphorylation of Rex . |
| 4.2070 | 30.0508 | 10.6943 | Treatment of an HTLV-I infected human T-cell line with H-7 blocked specifically accumulation of the RNAunspliced gag-pol mRNA , resulting in the decreased Gag protein synthesis that corresponds with the decreased in vivo phosphorylation of Rex . |
| 2.1246 | 20.2087 | 1.0000 | Treatment of an HTLV-I infected human T-cell line with H-7 blocked specifically accumulation of the unspliced gag-pol mRNA , resulting in the decreased Gag protein synthesis that corresponds with the decreased in vivo phosphorylation of proteinRex . |
| 1.4133 | 10.7643 | 1.0000 | Treatment of an HTLV-I infected human T-cell line with H-7 blocked specifically accumulation of the unspliced gag-pol mRNA , resulting in the decreased proteinGag protein synthesis that corresponds with the decreased in vivo phosphorylation of Rex . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6309 | 10.5096 | 1.0000 | Therefore, the phosphorylation of proteinRex is required for the viral RNA partition of HTLV-I . |
| 1.6674 | 10.7847 | 1.0000 | Therefore, the phosphorylation of Rex is required for the RNAviral RNA partition of HTLV-I . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9963 | 20.4653 | 10.6521 | Increased glucocorticoid responsiveness of cell_lineCD4+ T-cell clonal lines grown in serum-free media . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.0552 | 30.4660 | 20.6865 | CEM-C7 , a cell_linehuman leukemic CD4+ T-lymphocyte cell line and three of its subclones, CEM-4R4 , CEM-3R43 , and ICR-27 , previously cultured in a medium supplemented with 5 to 10% fetal bovine serum , have been adapted to serum-free media . |
| 1.7962 | 10.3998 | 1.0000 | CEM-C7 , a human leukemic CD4+ T-lymphocyte cell line and three of its subclones, CEM-4R4 , CEM-3R43 , and cell_lineICR-27 , previously cultured in a medium supplemented with 5 to 10% fetal bovine serum , have been adapted to serum-free media . |
| 0.9346 | 1.0000 | 1.0000 | CEM-C7 , a human leukemic CD4+ T-lymphocyte cell line and three of its subclones, cell_lineCEM-4R4 , CEM-3R43 , and ICR-27 , previously cultured in a medium supplemented with 5 to 10% fetal bovine serum , have been adapted to serum-free media . |
| 0.9136 | 1.0000 | 1.0000 | CEM-C7 , a human leukemic CD4+ T-lymphocyte cell line and three of its subclones, CEM-4R4 , cell_lineCEM-3R43 , and ICR-27 , previously cultured in a medium supplemented with 5 to 10% fetal bovine serum , have been adapted to serum-free media . |
| 0.8983 | 0.9999 | 1.0000 | cell_lineCEM-C7 , a human leukemic CD4+ T-lymphocyte cell line and three of its subclones, CEM-4R4 , CEM-3R43 , and ICR-27 , previously cultured in a medium supplemented with 5 to 10% fetal bovine serum , have been adapted to serum-free media . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9199 | 20.9830 | 10.8919 | The best medium of those tested was RPMI 1640 supplemented with 5 micrograms/ml each transferrin and insulin + 5 ng/ml sodium selenite +/- 0.1% proteinbovine serum albumin . |
| 0.9357 | 1.0000 | 1.0000 | The best medium of those tested was RPMI 1640 supplemented with 5 micrograms/ml each transferrin and proteininsulin + 5 ng/ml sodium selenite +/- 0.1% bovine serum albumin . |
| 0.8945 | 1.0000 | 1.0000 | The best medium of those tested was RPMI 1640 supplemented with 5 micrograms/ml each proteintransferrin and insulin + 5 ng/ml sodium selenite +/- 0.1% bovine serum albumin . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4901 | 10.9558 | 0.9999 | While growing either with or without albumin, the several cell_lineclonal lines of CEM cells displayed growth similar to serum-supplemented cultures. |
| 1.6069 | 10.6405 | 0.9998 | While growing either with or without albumin, the several clonal lines of cell_lineCEM cells displayed growth similar to serum-supplemented cultures. |
| While growing either with or without albumin, the several clonal lines of cell_lineCEM cells displayed growth similar to serum-supplemented cultures. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3129 | 20.3583 | 0.9999 | Cell proliferation of cell_lineCEM-C7 cells cultured in both serum-free media has been sustained for 3 mo. |
| Cell proliferation of cell_lineCEM-C7 cells cultured in both serum-free media has been sustained for 3 mo. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7538 | 20.7724 | 10.1666 | The expression of CD4 , a marker for cell_typeT-derived lymphoid cells , was not significantly different in serum-free medium . |
| 2.3788 | 20.2818 | 1.0000 | The expression of proteinCD4 , a marker for T-derived lymphoid cells , was not significantly different in serum-free medium . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1465 | 20.2109 | 1.0000 | When grown in serum-free medium, CEM-C7 cells exhibited increased steroid responsiveness as evidenced by increased glucocorticoid receptor binding sites , increased induction of proteinglutamine synthetase , and cell lysis at lower concentrations of steroid . |
| 1.8695 | 20.9374 | 0.9727 | When grown in serum-free medium, CEM-C7 cells exhibited increased steroid responsiveness as evidenced by increased proteinglucocorticoid receptor binding sites , increased induction of glutamine synthetase , and cell lysis at lower concentrations of steroid . |
| 3.9315 | 20.9660 | 10.8495 | When grown in serum-free medium, CEM-C7 cells exhibited increased steroid responsiveness as evidenced by increased proteinglucocorticoid receptor binding sites , increased induction of glutamine synthetase , and cell lysis at lower concentrations of steroid . |
| 1.6207 | 10.8582 | 0.9999 | When grown in serum-free medium, cell_lineCEM-C7 cells exhibited increased steroid responsiveness as evidenced by increased glucocorticoid receptor binding sites , increased induction of glutamine synthetase , and cell lysis at lower concentrations of steroid . |
| When grown in serum-free medium, cell_lineCEM-C7 cells exhibited increased steroid responsiveness as evidenced by increased glucocorticoid receptor binding sites , increased induction of glutamine synthetase , and cell lysis at lower concentrations of steroid . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8349 | 10.1331 | 1.0000 | Receptor mutant subclones of cell_lineCEM-C7 , which are proven to be completely unresponsive to micromolar concentrations of dexamethasone when grown in serum-supplemented medium , become partially sensitive to the hormone after growth in defined medium. |
| 1.6716 | 0.9963 | 10.1181 | cell_lineReceptor mutant subclones of CEM-C7 , which are proven to be completely unresponsive to micromolar concentrations of dexamethasone when grown in serum-supplemented medium , become partially sensitive to the hormone after growth in defined medium. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4440 | 20.3973 | 1.0000 | The increased sensitivity of cell_lineCEM-C7 cells and its subclones to dexamethasone in serum-free medium returned to previous levels when these cells were recultured in serum-containing medium . |
| The increased sensitivity of cell_lineCEM-C7 cells and its subclones to dexamethasone in serum-free medium returned to previous levels when these cells were recultured in serum-containing medium . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8859 | 0.9975 | 1.0000 | [ proteinGlucocorticoid receptors on human peripheral mononuclear and polymorphonuclear leucocytes : changes in patients with yang-deficiency ] |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8233 | 20.0299 | 10.7197 | It was found that, in former works, the glucocorticoid receptors ( GCR ) on cell_typeperipheral mixed leucocytes in patients with Yang-deficiency were decreased. |
| 1.4958 | 10.9855 | 1.0000 | It was found that, in former works, the proteinglucocorticoid receptors ( GCR ) on peripheral mixed leucocytes in patients with Yang-deficiency were decreased. |
| 0.9533 | 1.0000 | 1.0000 | It was found that, in former works, the glucocorticoid receptors ( proteinGCR ) on peripheral mixed leucocytes in patients with Yang-deficiency were decreased. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1370 | 20.6770 | 0.9999 | In this work, the cell_typemixed leucocytes were further separated into mononuclear (MNL) and polymorphonuclear (PML) leucocytes , and GCR were determined in each part of leucocytes . |
| 1.5578 | 10.4377 | 0.9999 | In this work, the mixed leucocytes were further separated into mononuclear (MNL) and polymorphonuclear (PML) leucocytes , and GCR were determined in each part of cell_typeleucocytes . |
| 0.9323 | 1.0000 | 1.0000 | In this work, the mixed leucocytes were further separated into mononuclear (MNL) and polymorphonuclear (PML) leucocytes , and proteinGCR were determined in each part of leucocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9614 | 1.0000 | 1.0000 | GCR on MNL and cell_typePML in 6 Yang deficient patients were 3473 +/- 413 and 4433 +/- 651 sites/cell respectively, statistically significant from the normal control group (4462 +/- 962 and 5622 +/- 782 sites/cell respectively, P less than 0.05). |
| 0.9465 | 1.0000 | 1.0000 | proteinGCR on MNL and PML in 6 Yang deficient patients were 3473 +/- 413 and 4433 +/- 651 sites/cell respectively, statistically significant from the normal control group (4462 +/- 962 and 5622 +/- 782 sites/cell respectively, P less than 0.05). |
| 0.9229 | 0.9999 | 1.0000 | GCR on cell_typeMNL and PML in 6 Yang deficient patients were 3473 +/- 413 and 4433 +/- 651 sites/cell respectively, statistically significant from the normal control group (4462 +/- 962 and 5622 +/- 782 sites/cell respectively, P less than 0.05). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6035 | 10.3371 | 0.9999 | GCR on MNL , PML and cell_typemixed leucocytes in 5 patients were determined simultaneously, and all lowered from the control group . |
| 0.9588 | 1.0000 | 1.0000 | proteinGCR on MNL , PML and mixed leucocytes in 5 patients were determined simultaneously, and all lowered from the control group . |
| 0.9368 | 1.0000 | 1.0000 | GCR on MNL , cell_typePML and mixed leucocytes in 5 patients were determined simultaneously, and all lowered from the control group . |
| 0.9120 | 0.9998 | 1.0000 | GCR on cell_typeMNL , PML and mixed leucocytes in 5 patients were determined simultaneously, and all lowered from the control group . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7482 | 10.1443 | 1.0000 | The results were 3369 +/- 370, 4986 +/- 419 and 4524 +/- 852 sites/cell respectively, with the lowest proteinGCR on MNL and highest on PML . |
| 1.6913 | 10.4425 | 1.0000 | The results were 3369 +/- 370, 4986 +/- 419 and 4524 +/- 852 sites/cell respectively, with the lowest GCR on MNL and highest on cell_typePML . |
| 0.8933 | 0.9999 | 1.0000 | The results were 3369 +/- 370, 4986 +/- 419 and 4524 +/- 852 sites/cell respectively, with the lowest GCR on cell_typeMNL and highest on PML . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8713 | 10.7801 | 10.9827 | The proteinubiquitous octamer-binding protein (s) is sufficient for transcription of immunoglobulin genes . |
| 1.9270 | 20.5474 | 0.9999 | The ubiquitous octamer-binding protein (s) is sufficient for transcription of DNAimmunoglobulin genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8380 | 20.5879 | 10.4713 | All immunoglobulin genes contain a conserved DNAoctanucleotide promoter element , ATGCAAAT , which has been shown to be required for their normal B-cell-specific transcription . |
| 1.5326 | 10.9768 | 0.9999 | All DNAimmunoglobulin genes contain a conserved octanucleotide promoter element , ATGCAAAT , which has been shown to be required for their normal B-cell-specific transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6427 | 10.4809 | 1.0000 | Proteins that bind this octamer have been purified, and DNAcDNAs encoding octamer-binding proteins have been cloned. |
| 1.5900 | 10.7989 | 1.0000 | Proteins that bind this octamer have been purified, and cDNAs encoding proteinoctamer-binding proteins have been cloned. |
| 1.6660 | 10.3388 | 1.0000 | Proteins that bind this DNAoctamer have been purified, and cDNAs encoding octamer-binding proteins have been cloned. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7401 | 10.1938 | 1.0000 | Some of these proteins (referred to as proteinOTF-2 ) are lymphoid specific, whereas at least one other, and possibly more (referred to as OTF-1 ), is found ubiquitously in all cell types. |
| 1.7243 | 10.3268 | 1.0000 | Some of these proteins (referred to as OTF-2 ) are lymphoid specific, whereas at least one other, and possibly more (referred to as proteinOTF-1 ), is found ubiquitously in all cell types. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3897 | 20.5404 | 1.0000 | The exact role of these different proteins in directing the tissue-specific expression of DNAimmunoglobulin genes is unclear. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8480 | 20.5027 | 10.8860 | We have identified two cell_linehuman pre-B-cell lines that contain extremely low levels of OTF-2 yet still express high levels of steady-state immunoglobulin heavy-chain mRNA in vivo and efficiently transcribe an immunoglobulin gene in vitro. |
| 2.0880 | 20.4339 | 1.0000 | We have identified two human pre-B-cell lines that contain extremely low levels of OTF-2 yet still express high levels of steady-state immunoglobulin heavy-chain mRNA in vivo and efficiently transcribe an DNAimmunoglobulin gene in vitro. |
| 1.4354 | 20.1944 | 0.8311 | We have identified two human pre-B-cell lines that contain extremely low levels of OTF-2 yet still express high levels of steady-state proteinimmunoglobulin heavy-chain mRNA in vivo and efficiently transcribe an immunoglobulin gene in vitro. |
| 0.8498 | 1.0000 | 1.0000 | We have identified two human pre-B-cell lines that contain extremely low levels of proteinOTF-2 yet still express high levels of steady-state immunoglobulin heavy-chain mRNA in vivo and efficiently transcribe an immunoglobulin gene in vitro. |
| 2.6485 | 20.0047 | 0.9998 | We have identified two human pre-B-cell lines that contain extremely low levels of OTF-2 yet still express high levels of steady-state RNAimmunoglobulin heavy-chain mRNA in vivo and efficiently transcribe an immunoglobulin gene in vitro. |
| We have identified two human pre-B-cell lines that contain extremely low levels of OTF-2 yet still express high levels of RNAsteady-state immunoglobulin heavy-chain mRNA in vivo and efficiently transcribe an immunoglobulin gene in vitro. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1717 | 20.5976 | 0.9999 | Addition of a highly enriched preparation of OTF-1 made from one of these pre-B cells or from HeLa cells specifically stimulated in vitro transcription of an DNAimmunoglobulin gene . |
| 1.6121 | 10.8997 | 1.0000 | Addition of a highly enriched preparation of proteinOTF-1 made from one of these pre-B cells or from HeLa cells specifically stimulated in vitro transcription of an immunoglobulin gene . |
| 1.5887 | 10.7674 | 0.9999 | Addition of a highly enriched preparation of OTF-1 made from one of these pre-B cells or from cell_lineHeLa cells specifically stimulated in vitro transcription of an immunoglobulin gene . |
| 2.3212 | 20.2762 | 0.9999 | Addition of a highly enriched preparation of OTF-1 made from one of these cell_typepre-B cells or from HeLa cells specifically stimulated in vitro transcription of an immunoglobulin gene . |
| Addition of a highly enriched preparation of OTF-1 made from one of these cell_linepre-B cells or from HeLa cells specifically stimulated in vitro transcription of an immunoglobulin gene . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6306 | 10.7051 | 1.0000 | Furthermore, OFT-1 appeared to have approximately the same transactivation ability as proteinOTF-2 when normalized for binding activity. |
| 0.9317 | 1.0000 | 1.0000 | Furthermore, proteinOFT-1 appeared to have approximately the same transactivation ability as OTF-2 when normalized for binding activity. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2759 | 20.1043 | 1.0000 | These results suggest that OTF-1 , without OTF-2 , is sufficient for transcription of DNAimmunoglobulin genes and that OTF-2 alone is not responsible for the B-cell-specific regulation of immunoglobulin gene expression . |
| 2.2499 | 20.1758 | 0.9997 | These results suggest that OTF-1 , without OTF-2 , is sufficient for transcription of immunoglobulin genes and that OTF-2 alone is not responsible for the B-cell-specific regulation of DNAimmunoglobulin gene expression . |
| 1.6923 | 10.1295 | 1.0000 | These results suggest that proteinOTF-1 , without OTF-2 , is sufficient for transcription of immunoglobulin genes and that OTF-2 alone is not responsible for the B-cell-specific regulation of immunoglobulin gene expression . |
| 1.6572 | 10.4398 | 1.0000 | These results suggest that OTF-1 , without proteinOTF-2 , is sufficient for transcription of immunoglobulin genes and that OTF-2 alone is not responsible for the B-cell-specific regulation of immunoglobulin gene expression . |
| 0.8573 | 1.0000 | 1.0000 | These results suggest that OTF-1 , without OTF-2 , is sufficient for transcription of immunoglobulin genes and that proteinOTF-2 alone is not responsible for the B-cell-specific regulation of immunoglobulin gene expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1095 | 10.7598 | 10.2812 | In vitro binding of aldosterone to mineralocorticoid receptors on cell_typehuman mononuclear leukocytes ( HML ) and its effects on the intracellular sodium and potassium concentrations of HML have already been described. |
| 1.6186 | 10.7244 | 1.0000 | In vitro binding of aldosterone to mineralocorticoid receptors on human mononuclear leukocytes ( HML ) and its effects on the intracellular sodium and potassium concentrations of cell_typeHML have already been described. |
| 1.5253 | 10.9089 | 0.9999 | In vitro binding of aldosterone to proteinmineralocorticoid receptors on human mononuclear leukocytes ( HML ) and its effects on the intracellular sodium and potassium concentrations of HML have already been described. |
| 0.9420 | 1.0000 | 1.0000 | In vitro binding of aldosterone to mineralocorticoid receptors on human mononuclear leukocytes ( cell_typeHML ) and its effects on the intracellular sodium and potassium concentrations of HML have already been described. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8285 | 10.6575 | 1.0000 | In only four patients sodium in cell_typeHML without incubation was elevated compared with the range for normal persons . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9711 | 1.0000 | 1.0000 | Plasma proteinrenin activity and aldosterone were not correlated with the electrolyte response and were within the normal limits. |
| proteinPlasma renin activity and aldosterone were not correlated with the electrolyte response and were within the normal limits. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4279 | 20.7331 | 0.9988 | The number of proteinmineralocorticoid receptors /cell were within or close to the normal range (n = 9). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4406 | 20.5722 | 1.0000 | The independence of intracellular electrolytes from aldosterone despite a normal number of proteinmineralocorticoid receptors may reflect an impairment of the mineralocorticoid effector mechanism in the HML of patients with essential hypertension . |
| 1.7555 | 10.2281 | 1.0000 | The independence of intracellular electrolytes from aldosterone despite a normal number of mineralocorticoid receptors may reflect an impairment of the mineralocorticoid effector mechanism in the cell_typeHML of patients with essential hypertension . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7164 | 10.4515 | 1.0000 | [Differential diagnostic value of receptors of 1,25-dihydroxyvitamin D3 ( calcitriol ) determination in cell_typelymphocytes of children with rickets and rickets -like diseases ] |
| 1.6704 | 10.8869 | 1.0000 | [Differential diagnostic value of proteinreceptors of 1,25-dihydroxyvitamin D3 ( calcitriol ) determination in lymphocytes of children with rickets and rickets -like diseases ] |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7456 | 10.2588 | 1.0000 | The authors provide the results of studying 1,25-dihydroxyvitamin D3 ( calcitriol ) in cell_typelymphocytes of children with rickets and rickets -like diseases . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9209 | 20.3770 | 10.4560 | Alteration of gene transcription by inhibition of specific proteintranscriptional regulatory proteins is necessary for determining how these factors participate in cellular differentiation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2414 | 20.5259 | 10.7746 | Inhibition of proteinsequence-specific DNA-binding proteins was achieved with double-stranded (ds) phosphorothioate oligonucleotides that contained octamer or kappa B consensus sequences . |
| 3.7230 | 20.3682 | 10.8310 | Inhibition of sequence-specific DNA-binding proteins was achieved with double-stranded (ds) phosphorothioate oligonucleotides that contained octamer or DNAkappa B consensus sequences . |
| 1.3934 | 10.2368 | 1.0000 | Inhibition of sequence-specific DNA-binding proteins was achieved with double-stranded (ds) phosphorothioate oligonucleotides that contained DNAoctamer or kappa B consensus sequences . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6250 | 20.0815 | 10.4351 | The phosphorothioate oligonucleotides specifically bound either proteinoctamer transcription factor or nuclear factor (NF)-kappa B . |
| 3.0938 | 10.9721 | 10.7137 | The phosphorothioate oligonucleotides specifically bound either octamer transcription factor or proteinnuclear factor (NF)-kappa B . |
| 1.3714 | 0.9998 | 10.0381 | The phosphorothioate oligonucleotides specifically bound either octamer proteintranscription factor or nuclear factor (NF)-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.1753 | 30.8142 | 10.8349 | Octamer-dependent activation of a reporter plasmid or NF-kappa B -dependent activation of the DNAhuman immunodeficiency virus ( HIV ) enhancer was inhibited when the appropriate phosphorothioate oligonucleotide was added to a transiently transfected B cell line . |
| 5.4499 | 30.7721 | 20.9781 | Octamer-dependent activation of a reporter plasmid or NF-kappa B -dependent activation of the human immunodeficiency virus ( HIV ) enhancer was inhibited when the appropriate phosphorothioate oligonucleotide was added to a cell_linetransiently transfected B cell line . |
| 1.7616 | 20.7681 | 0.9999 | Octamer-dependent activation of a DNAreporter plasmid or NF-kappa B -dependent activation of the human immunodeficiency virus ( HIV ) enhancer was inhibited when the appropriate phosphorothioate oligonucleotide was added to a transiently transfected B cell line . |
| 1.4548 | 10.6359 | 1.0000 | Octamer-dependent activation of a reporter plasmid or proteinNF-kappa B -dependent activation of the human immunodeficiency virus ( HIV ) enhancer was inhibited when the appropriate phosphorothioate oligonucleotide was added to a transiently transfected B cell line . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5563 | 20.9378 | 10.8349 | Addition of phosphorothioate oligonucleotides that contained the octamer consensus to Jurkat T leukemia cells inhibited interleukin-2 ( IL-2 ) secretion to a degree similar to that observed with a DNAmutated octamer site in the IL-2 enhancer . |
| 3.1922 | 10.5137 | 10.8435 | Addition of phosphorothioate oligonucleotides that contained the octamer consensus to cell_lineJurkat T leukemia cells inhibited interleukin-2 ( IL-2 ) secretion to a degree similar to that observed with a mutated octamer site in the IL-2 enhancer . |
| 2.1398 | 20.5647 | 0.9999 | Addition of phosphorothioate oligonucleotides that contained the octamer consensus to Jurkat T leukemia cells inhibited interleukin-2 ( IL-2 ) secretion to a degree similar to that observed with a mutated octamer site in the DNAIL-2 enhancer . |
| 1.9569 | 20.4087 | 0.9997 | Addition of phosphorothioate oligonucleotides that contained the DNAoctamer consensus to Jurkat T leukemia cells inhibited interleukin-2 ( IL-2 ) secretion to a degree similar to that observed with a mutated octamer site in the IL-2 enhancer . |
| 0.9804 | 1.0000 | 1.0000 | Addition of phosphorothioate oligonucleotides that contained the octamer consensus to Jurkat T leukemia cells inhibited interleukin-2 ( proteinIL-2 ) secretion to a degree similar to that observed with a mutated octamer site in the IL-2 enhancer . |
| 0.9715 | 1.0000 | 1.0000 | Addition of phosphorothioate oligonucleotides that contained the octamer consensus to Jurkat T leukemia cells inhibited proteininterleukin-2 ( IL-2 ) secretion to a degree similar to that observed with a mutated octamer site in the IL-2 enhancer . |
| 1.5313 | 20.8856 | 0.9785 | Addition of phosphorothioate oligonucleotides that contained the octamer consensus to Jurkat T leukemia cells inhibited interleukin-2 ( IL-2 ) secretion to a degree similar to that observed with a mutated octamer site in the proteinIL-2 enhancer . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6408 | 10.9568 | 1.0000 | The ds phosphorothioate oligonucleotides probably compete for binding of specific proteintranscription factors and may provide anti-viral , immunosuppressive , or other therapeutic effects . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6163 | 10.8672 | 1.0000 | [Effect of the regimen of kidney-tonifying and qi-invigorating on aging changes of proteinglucocorticoid receptor ] |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3396 | 20.5166 | 1.0000 | The plasma cortisol concentration and the sites of proteinglucocorticoid receptor ( GCR ) in the peripheral lymphocytes were measured in 32 healthy aged persons and 13 young adults . |
| 1.6136 | 10.9528 | 0.9999 | The plasma cortisol concentration and the sites of glucocorticoid receptor ( GCR ) in the cell_typeperipheral lymphocytes were measured in 32 healthy aged persons and 13 young adults . |
| 0.9711 | 1.0000 | 1.0000 | The plasma cortisol concentration and the sites of glucocorticoid receptor ( proteinGCR ) in the peripheral lymphocytes were measured in 32 healthy aged persons and 13 young adults . |
| The plasma cortisol concentration and the sites of glucocorticoid receptor ( GCR ) in the peripheral cell_typelymphocytes were measured in 32 healthy aged persons and 13 young adults . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0255 | 20.7828 | 10.7537 | In animal experiment , GCR of cell_typespleen lymphocytic cell was also measured in 18 aged rats and 9 young rats . |
| 1.5466 | 10.9824 | 1.0000 | In animal experiment , proteinGCR of spleen lymphocytic cell was also measured in 18 aged rats and 9 young rats . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7804 | 10.6459 | 1.0000 | The results showed that proteinGCR was significantly lower in the aged persons or rats than that in the young while the plasma cortisol level didn't change with aging. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7490 | 10.5715 | 1.0000 | So we think that proteinGCR is more sensitive than the plasma cortisol level to reflect the aging change of the adrenal cortex function . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8133 | 10.3469 | 1.0000 | After the treatment with the regimen of Kidney-tonifying and Qi-invigorating , the proteinGCR of the aged persons and rats was enhanced, and in this way, the function of the aged adrenal cortex was improved. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6214 | 10.9834 | 1.0000 | Interferon affects proteinnuclear proteins in cells of clinically sensitive chronic myelogenous leukemia patients . |
| 0.9608 | 1.0000 | 1.0000 | proteinInterferon affects nuclear proteins in cells of clinically sensitive chronic myelogenous leukemia patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9981 | 20.3306 | 0.9999 | Cytoplasmic protein extracts from chronic myelogenous leukemia ( CML ) cells contained an activity that altered the electrophoretic mobility of complexes formed between proteinnuclear proteins and the transcriptional enhancers of interferon (IFN)-inducible genes. |
| 5.8710 | 30.2593 | 20.6475 | Cytoplasmic protein extracts from cell_linechronic myelogenous leukemia ( CML ) cells contained an activity that altered the electrophoretic mobility of complexes formed between nuclear proteins and the transcriptional enhancers of interferon (IFN)-inducible genes. |
| 1.2977 | 10.4894 | 0.9997 | Cytoplasmic protein extracts from chronic myelogenous leukemia ( CML ) cells contained an activity that altered the electrophoretic mobility of complexes formed between nuclear proteins and the DNAtranscriptional enhancers of interferon (IFN)-inducible genes. |
| Cytoplasmic protein extracts from cell_typechronic myelogenous leukemia ( CML ) cells contained an activity that altered the electrophoretic mobility of complexes formed between nuclear proteins and the transcriptional enhancers of interferon (IFN)-inducible genes. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4914 | 20.3707 | 10.6499 | Exposure of CML cells to IFN-alpha diminished the effect of the proteinCML cytoplasmic proteins on these nuclear protein-DNA complexes . |
| 3.3658 | 20.3514 | 10.8826 | Exposure of CML cells to IFN-alpha diminished the effect of the CML cytoplasmic proteins on these proteinnuclear protein-DNA complexes . |
| 0.8467 | 1.0000 | 1.0000 | Exposure of CML cells to proteinIFN-alpha diminished the effect of the CML cytoplasmic proteins on these nuclear protein-DNA complexes . |
| 2.1195 | 20.1818 | 0.9999 | Exposure of cell_lineCML cells to IFN-alpha diminished the effect of the CML cytoplasmic proteins on these nuclear protein-DNA complexes . |
| 0.6766 | 0.9997 | 0.9998 | Exposure of CML cells to IFN-alpha diminished the effect of the CML proteincytoplasmic proteins on these nuclear protein-DNA complexes . |
| Exposure of cell_typeCML cells to IFN-alpha diminished the effect of the CML cytoplasmic proteins on these nuclear protein-DNA complexes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7349 | 20.8293 | 10.4580 | The presence of clinical responsiveness to IFN-alpha correlated with the sensitivity to the IFN -induced change in the electrophoretic mobility of proteinnuclear protein-DNA complexes . |
| 1.5692 | 10.7372 | 1.0000 | The presence of clinical responsiveness to proteinIFN-alpha correlated with the sensitivity to the IFN -induced change in the electrophoretic mobility of nuclear protein-DNA complexes . |
| 0.9130 | 1.0000 | 1.0000 | The presence of clinical responsiveness to IFN-alpha correlated with the sensitivity to the proteinIFN -induced change in the electrophoretic mobility of nuclear protein-DNA complexes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4045 | 20.3622 | 1.0000 | These data suggest that the action of IFN-alpha in CML may be linked to a pathway that can result in posttranslational modification of proteinnuclear proteins . |
| 1.6994 | 10.6258 | 1.0000 | These data suggest that the action of proteinIFN-alpha in CML may be linked to a pathway that can result in posttranslational modification of nuclear proteins . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3721 | 20.6883 | 10.3524 | Epstein-Barr virus nuclear antigen 2 transactivates proteinlatent membrane protein LMP1 . |
| 2.3152 | 0.9992 | 20.2643 | proteinEpstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1 . |
| 0.9771 | 1.0000 | 0.9999 | Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein proteinLMP1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.3265 | 30.8928 | 20.0481 | Several lines of evidence are compatible with the hypothesis that proteinEpstein-Barr virus ( EBV ) nuclear antigen 2 ( EBNA-2 ) or leader protein ( EBNA-LP ) affects expression of the EBV latent infection membrane protein LMP1 . |
| 4.2990 | 40.8119 | 20.3696 | Several lines of evidence are compatible with the hypothesis that Epstein-Barr virus ( EBV ) nuclear antigen 2 ( EBNA-2 ) or leader protein ( EBNA-LP ) affects expression of the proteinEBV latent infection membrane protein LMP1 . |
| 1.2813 | 10.9973 | 1.0000 | Several lines of evidence are compatible with the hypothesis that Epstein-Barr virus ( EBV ) nuclear antigen 2 ( EBNA-2 ) or proteinleader protein ( EBNA-LP ) affects expression of the EBV latent infection membrane protein LMP1 . |
| 0.9649 | 1.0000 | 1.0000 | Several lines of evidence are compatible with the hypothesis that Epstein-Barr virus ( EBV ) nuclear antigen 2 ( proteinEBNA-2 ) or leader protein ( EBNA-LP ) affects expression of the EBV latent infection membrane protein LMP1 . |
| 0.9487 | 0.9996 | 0.9999 | Several lines of evidence are compatible with the hypothesis that Epstein-Barr virus ( EBV ) nuclear antigen 2 ( EBNA-2 ) or leader protein ( EBNA-LP ) affects expression of the EBV latent infection membrane protein proteinLMP1 . |
| 0.9258 | 1.0000 | 1.0000 | Several lines of evidence are compatible with the hypothesis that Epstein-Barr virus ( EBV ) nuclear antigen 2 ( EBNA-2 ) or leader protein ( proteinEBNA-LP ) affects expression of the EBV latent infection membrane protein LMP1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.5168 | 30.5931 | 10.7709 | (i) Acute transfection and expression of EBNA-2 under control of simian virus 40 or Moloney murine leukemia virus promoters resulted in increased LMP1 expression in cell_lineP3HR-1-infected Burkitt's lymphoma cells and the P3HR-1 or Daudi cell line . |
| 1.5947 | 10.2939 | 1.0000 | (i) Acute transfection and expression of EBNA-2 under control of simian virus 40 or Moloney murine leukemia virus promoters resulted in increased proteinLMP1 expression in P3HR-1-infected Burkitt's lymphoma cells and the P3HR-1 or Daudi cell line . |
| 1.4828 | 10.5728 | 1.0000 | (i) Acute transfection and expression of proteinEBNA-2 under control of simian virus 40 or Moloney murine leukemia virus promoters resulted in increased LMP1 expression in P3HR-1-infected Burkitt's lymphoma cells and the P3HR-1 or Daudi cell line . |
| 1.4005 | 20.8606 | 0.9994 | (i) Acute transfection and expression of EBNA-2 under control of simian virus 40 or Moloney murine leukemia virus promoters resulted in increased LMP1 expression in P3HR-1-infected Burkitt's lymphoma cells and the P3HR-1 or cell_lineDaudi cell line . |
| 0.7855 | 0.9999 | 1.0000 | (i) Acute transfection and expression of EBNA-2 under control of simian virus 40 or Moloney murine leukemia virus promoters resulted in increased LMP1 expression in P3HR-1-infected Burkitt's lymphoma cells and the proteinP3HR-1 or Daudi cell line . |
| (i) Acute transfection and expression of EBNA-2 under control of simian virus 40 or Moloney murine leukemia virus promoters resulted in increased LMP1 expression in P3HR-1-infected Burkitt's lymphoma cells and the cell_lineP3HR-1 or Daudi cell line . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6051 | 10.5955 | 1.0000 | (ii) Transfection and expression of EBNA-LP alone had no effect on proteinLMP1 expression and did not act synergistically with EBNA-2 to affect LMP1 expression . |
| 1.6025 | 10.4854 | 1.0000 | (ii) Transfection and expression of EBNA-LP alone had no effect on LMP1 expression and did not act synergistically with proteinEBNA-2 to affect LMP1 expression . |
| 1.5653 | 10.8852 | 1.0000 | (ii) Transfection and expression of EBNA-LP alone had no effect on LMP1 expression and did not act synergistically with EBNA-2 to affect proteinLMP1 expression . |
| 1.5574 | 10.7753 | 1.0000 | (ii) Transfection and expression of proteinEBNA-LP alone had no effect on LMP1 expression and did not act synergistically with EBNA-2 to affect LMP1 expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5497 | 10.5299 | 1.0000 | (iii) LMP1 expression in cell_lineDaudi and P3HR-1-infected cells was controlled at the mRNA level , and EBNA-2 expression in Daudi cells increased LMP1 mRNA . |
| 1.5390 | 10.8381 | 0.9998 | (iii) LMP1 expression in Daudi and P3HR-1-infected cells was controlled at the mRNA level , and EBNA-2 expression in Daudi cells increased RNALMP1 mRNA . |
| 1.4201 | 10.3520 | 0.9998 | (iii) LMP1 expression in Daudi and P3HR-1-infected cells was controlled at the mRNA level , and EBNA-2 expression in cell_lineDaudi cells increased LMP1 mRNA . |
| 1.3062 | 10.1975 | 0.9819 | (iii) LMP1 expression in Daudi and P3HR-1-infected cells was controlled at the mRNA level , and EBNA-2 expression in Daudi cells increased proteinLMP1 mRNA . |
| 1.2150 | 10.9466 | 0.9997 | (iii) LMP1 expression in Daudi and cell_lineP3HR-1-infected cells was controlled at the mRNA level , and EBNA-2 expression in Daudi cells increased LMP1 mRNA . |
| 0.9612 | 1.0000 | 1.0000 | (iii) proteinLMP1 expression in Daudi and P3HR-1-infected cells was controlled at the mRNA level , and EBNA-2 expression in Daudi cells increased LMP1 mRNA . |
| 0.8889 | 0.9999 | 1.0000 | (iii) LMP1 expression in Daudi and P3HR-1-infected cells was controlled at the mRNA level , and proteinEBNA-2 expression in Daudi cells increased LMP1 mRNA . |
| (iii) LMP1 expression in Daudi and P3HR-1-infected cells was controlled at the RNAmRNA level , and EBNA-2 expression in Daudi cells increased LMP1 mRNA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1732 | 20.9304 | 10.8221 | (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of DNArecombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , Louckes , and BL30 . |
| 3.7142 | 20.3727 | 10.9935 | (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the cell_lineEBV-negative B-lymphoma cell lines BJAB , Louckes , and BL30 . |
| 1.7530 | 20.5047 | 0.9999 | (iv) No other DNAEBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , Louckes , and BL30 . |
| 1.6597 | 10.2067 | 1.0000 | (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , Louckes , and cell_lineBL30 . |
| 1.4079 | 10.6719 | 1.0000 | (iv) No other EBV genes were required for EBNA-2 transactivation of proteinLMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , Louckes , and BL30 . |
| 0.9587 | 1.0000 | 1.0000 | (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced proteinLMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , Louckes , and BL30 . |
| 0.9416 | 0.9999 | 1.0000 | (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines cell_lineBJAB , Louckes , and BL30 . |
| 0.9127 | 1.0000 | 1.0000 | (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , cell_lineLouckes , and BL30 . |
| 0.9127 | 1.0000 | 0.9885 | (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant proteinEBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , Louckes , and BL30 . |
| 0.9076 | 1.0000 | 0.9941 | (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic proteinLMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , Louckes , and BL30 . |
| 0.7905 | 1.0000 | 1.0000 | (iv) No other EBV genes were required for proteinEBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , Louckes , and BL30 . |
| 3.7267 | 20.6623 | 10.5273 | (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and DNAgenomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , Louckes , and BL30 . |
| (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic DNALMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB , Louckes , and BL30 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8291 | 20.9330 | 10.7857 | (v) An EBNA-2 -responsive element was found within the -512 to +40 LMP1 DNA since this DNA linked to a DNAchloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an EBNA-2 expression vector . |
| 2.8572 | 20.9038 | 10.8052 | (v) An EBNA-2 -responsive element was found within the -512 to +40 LMP1 DNA since this DNA linked to a chloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an DNAEBNA-2 expression vector . |
| 2.1997 | 20.6378 | 10.9972 | (v) An DNAEBNA-2 -responsive element was found within the -512 to +40 LMP1 DNA since this DNA linked to a chloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an EBNA-2 expression vector . |
| 2.1458 | 20.3352 | 0.9999 | (v) An EBNA-2 -responsive element was found within the -512 to +40 DNALMP1 DNA since this DNA linked to a chloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an EBNA-2 expression vector . |
| 2.1322 | 20.1102 | 0.9905 | (v) An EBNA-2 -responsive element was found within the -512 to +40 proteinLMP1 DNA since this DNA linked to a chloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an EBNA-2 expression vector . |
| 1.9650 | 20.5851 | 0.9952 | (v) An EBNA-2 -responsive element was found within the -512 to +40 LMP1 DNA since this DNA linked to a chloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an proteinEBNA-2 expression vector . |
| 1.4797 | 10.6776 | 0.9973 | (v) An proteinEBNA-2 -responsive element was found within the -512 to +40 LMP1 DNA since this DNA linked to a chloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an EBNA-2 expression vector . |
| (v) An EBNA-2 -responsive element was found within the -512 to +40 LMP1 DNA since this DNA linked to a proteinchloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an EBNA-2 expression vector . | |||
| (v) An EBNA-2 -responsive element was found within the DNA-512 to +40 LMP1 DNA since this DNA linked to a chloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an EBNA-2 expression vector . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4065 | 20.7978 | 10.7246 | (vi) The EBV type 2 EBNA-2 transactivated LMP1 as well as the proteinEBV type 1 EBNA-2 . |
| 0.9203 | 0.9999 | 1.0000 | (vi) The EBV type 2 proteinEBNA-2 transactivated LMP1 as well as the EBV type 1 EBNA-2 . |
| 0.9091 | 0.9999 | 1.0000 | (vi) The EBV type 2 EBNA-2 transactivated LMP1 as well as the EBV type 1 proteinEBNA-2 . |
| 0.8576 | 0.9999 | 1.0000 | (vi) The EBV type 2 EBNA-2 transactivated proteinLMP1 as well as the EBV type 1 EBNA-2 . |
| 3.5017 | 20.6627 | 10.8287 | (vi) The proteinEBV type 2 EBNA-2 transactivated LMP1 as well as the EBV type 1 EBNA-2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9224 | 20.3683 | 0.9922 | (vii) Two deletions within the proteinEBNA-2 gene which rendered EBV transformation incompetent did not transactivate LMP1 , whereas a transformation-competent EBNA-2 deletion mutant did transactivate LMP1 . |
| 1.5079 | 10.3640 | 1.0000 | (vii) Two deletions within the EBNA-2 gene which rendered EBV transformation incompetent did not transactivate proteinLMP1 , whereas a transformation-competent EBNA-2 deletion mutant did transactivate LMP1 . |
| 1.4399 | 10.2011 | 1.0000 | (vii) Two deletions within the EBNA-2 gene which rendered EBV transformation incompetent did not transactivate LMP1 , whereas a transformation-competent EBNA-2 deletion mutant did transactivate proteinLMP1 . |
| 0.9251 | 1.0000 | 0.9969 | (vii) Two deletions within the EBNA-2 gene which rendered EBV transformation incompetent did not transactivate LMP1 , whereas a transformation-competent proteinEBNA-2 deletion mutant did transactivate LMP1 . |
| 4.6416 | 20.9000 | 10.9170 | (vii) Two deletions within the EBNA-2 gene which rendered EBV transformation incompetent did not transactivate LMP1 , whereas a proteintransformation-competent EBNA-2 deletion mutant did transactivate LMP1 . |
| 2.0209 | 20.3385 | 1.0000 | (vii) Two deletions within the DNAEBNA-2 gene which rendered EBV transformation incompetent did not transactivate LMP1 , whereas a transformation-competent EBNA-2 deletion mutant did transactivate LMP1 . |
| (vii) Two deletions within the EBNA-2 gene which rendered EBV transformation incompetent did not transactivate LMP1 , whereas a DNAtransformation-competent EBNA-2 deletion mutant did transactivate LMP1 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6346 | 10.1351 | 1.0000 | LMP1 is a potent effector of B-lymphocyte activation and can act synergistically with proteinEBNA-2 to induce cellular CD23 gene expression . |
| 0.9749 | 1.0000 | 1.0000 | proteinLMP1 is a potent effector of B-lymphocyte activation and can act synergistically with EBNA-2 to induce cellular CD23 gene expression . |
| 2.2486 | 20.7535 | 0.9999 | LMP1 is a potent effector of B-lymphocyte activation and can act synergistically with EBNA-2 to induce cellular DNACD23 gene expression . |
| 1.6237 | 10.0759 | 1.0000 | LMP1 is a potent effector of cell_typeB-lymphocyte activation and can act synergistically with EBNA-2 to induce cellular CD23 gene expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6902 | 10.3920 | 1.0000 | Thus, EBNA-2 transactivation of proteinLMP1 amplifies the biological impact of EBNA-2 and underscores its central role in EBV-induced growth transformation . |
| 1.6846 | 10.2686 | 1.0000 | Thus, EBNA-2 transactivation of LMP1 amplifies the biological impact of proteinEBNA-2 and underscores its central role in EBV-induced growth transformation . |
| 0.9102 | 0.9999 | 1.0000 | Thus, proteinEBNA-2 transactivation of LMP1 amplifies the biological impact of EBNA-2 and underscores its central role in EBV-induced growth transformation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0285 | 20.8262 | 10.1091 | The expression of c-fos , c-jun , and c-myc genes is regulated by heat shock in cell_typehuman lymphoid cells . |
| The expression of DNAc-fos , c-jun , and c-myc genes is regulated by heat shock in human lymphoid cells . | |||
| The expression of c-fos , DNAc-jun , and c-myc genes is regulated by heat shock in human lymphoid cells . | |||
| The expression of c-fos , c-jun , and DNAc-myc genes is regulated by heat shock in human lymphoid cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0712 | 20.7336 | 0.9994 | The effect of heat shock on the expression of the DNAnuclear protooncogenes c-fos , c-jun , and c-myc was studied in human lymphoid cells . |
| 2.0471 | 20.3789 | 10.8111 | The effect of heat shock on the expression of the nuclear protooncogenes c-fos , c-jun , and c-myc was studied in cell_typehuman lymphoid cells . |
| 1.7305 | 10.9901 | 1.0000 | The effect of heat shock on the expression of the nuclear protooncogenes c-fos , c-jun , and DNAc-myc was studied in human lymphoid cells . |
| 0.9423 | 1.0000 | 1.0000 | The effect of heat shock on the expression of the nuclear protooncogenes c-fos , DNAc-jun , and c-myc was studied in human lymphoid cells . |
| 0.8734 | 1.0000 | 0.9999 | The effect of heat shock on the expression of the nuclear protooncogenes DNAc-fos , c-jun , and c-myc was studied in human lymphoid cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6338 | 10.8212 | 0.9999 | Heat shock caused an increase in c-fos and c-jun mRNA levels and a decrease in RNAc-myc mRNA levels in pre-B (Hyon) and T (DND-41) cell lines as well as in freshly isolated normal human thymocytes. |
| Heat shock caused an increase in c-fos and c-jun mRNA levels and a decrease in DNAc-myc mRNA levels in pre-B (Hyon) and T (DND-41) cell lines as well as in freshly isolated normal human thymocytes. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7742 | 10.6157 | 1.0000 | The changes in the mRNA levels of these DNAprotooncogenes in Hyon cells were most pronounced at 42 and 43 degrees C; kinetic analysis demonstrated that the changes could be detected within 30 min of heat shock . |
| 1.5044 | 10.6893 | 0.9999 | The changes in the mRNA levels of these protooncogenes in cell_lineHyon cells were most pronounced at 42 and 43 degrees C; kinetic analysis demonstrated that the changes could be detected within 30 min of heat shock . |
| 1.1506 | 10.0570 | 1.0000 | The changes in the RNAmRNA levels of these protooncogenes in Hyon cells were most pronounced at 42 and 43 degrees C; kinetic analysis demonstrated that the changes could be detected within 30 min of heat shock . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5483 | 10.0810 | 0.9999 | Altered transcription of c-fos and DNAc-myc genes was the primary effect of heat shock . |
| 1.5184 | 10.8407 | 1.0000 | Altered transcription of DNAc-fos and c-myc genes was the primary effect of heat shock . |
| Altered transcription of c-fos and DNAc-myc genes was the primary effect of heat shock . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7068 | 10.8694 | 1.0000 | Secondarily, heat shock of Hyon cells stabilized the RNAc-myc mRNA level by increasing its half-life from 24 to 45 min. |
| 1.5646 | 10.7832 | 0.9999 | Secondarily, heat shock of cell_typeHyon cells stabilized the c-myc mRNA level by increasing its half-life from 24 to 45 min. |
| Secondarily, heat shock of cell_lineHyon cells stabilized the c-myc mRNA level by increasing its half-life from 24 to 45 min. | |||
| Secondarily, heat shock of Hyon cells stabilized the DNAc-myc mRNA level by increasing its half-life from 24 to 45 min. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7510 | 10.9744 | 1.0000 | The overall effect of heat shock on RNAc-myc mRNA level , however, was a marked inhibition of its transcription . |
| The overall effect of heat shock on DNAc-myc mRNA level , however, was a marked inhibition of its transcription . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3275 | 20.2615 | 1.0000 | These results demonstrate that the transcription of DNAnuclear protooncogenes is regulated by heat shock indicating a role for nuclear protooncogenes in the stress response of lymphoid cells . |
| 2.1539 | 20.4041 | 1.0000 | These results demonstrate that the transcription of nuclear protooncogenes is regulated by heat shock indicating a role for DNAnuclear protooncogenes in the stress response of lymphoid cells . |
| 1.5099 | 10.9503 | 0.9997 | These results demonstrate that the transcription of nuclear protooncogenes is regulated by heat shock indicating a role for nuclear protooncogenes in the stress response of cell_typelymphoid cells . |
| 0.8530 | 1.0000 | 1.0000 | These results demonstrate that the transcription of nuclear protooncogenes is regulated by heat shock indicating a role for nuclear DNAprotooncogenes in the stress response of lymphoid cells . |
| These results demonstrate that the transcription of nuclear DNAprotooncogenes is regulated by heat shock indicating a role for nuclear protooncogenes in the stress response of lymphoid cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.7782 | 30.6678 | 20.9796 | Mapping of B-cell epitopes of the proteinhuman hepatitis B virus X protein . |
| 1.5429 | 20.4316 | 0.9997 | Mapping of proteinB-cell epitopes of the human hepatitis B virus X protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8320 | 20.7192 | 10.6109 | The immune response to the X protein of human hepatitis B virus ( HBV ) was studied by epitope mapping by using a set of proteinMS2-HBx fusion proteins and synthetic peptides . |
| 2.2115 | 20.8072 | 1.0000 | The immune response to the proteinX protein of human hepatitis B virus ( HBV ) was studied by epitope mapping by using a set of MS2-HBx fusion proteins and synthetic peptides . |
| 0.8866 | 1.0000 | 1.0000 | The immune response to the X protein of human hepatitis B virus ( HBV ) was studied by proteinepitope mapping by using a set of MS2-HBx fusion proteins and synthetic peptides . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.5435 | 0.9999 | 1.0000 | proteinAntibodies in sera of patients with acute and chronic HBV infection showed a multispecific immune response . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7580 | 10.4502 | 1.0000 | Each serum contained proteinantibodies to a different set of epitopes , which taken together cover most of the HBx sequence . |
| 1.7415 | 10.1500 | 1.0000 | Each serum contained antibodies to a different set of proteinepitopes , which taken together cover most of the HBx sequence . |
| 2.3623 | 20.3870 | 1.0000 | Each serum contained antibodies to a different set of epitopes , which taken together cover most of the DNAHBx sequence . |
| Each serum contained antibodies to a different set of epitopes , which taken together cover most of the proteinHBx sequence . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6894 | 10.8518 | 1.0000 | Some of the epitopes were detectable only by immunoblotting with proteinfusion proteins ; others were detectable only by an enzyme-linked immunosorbent assay ( ELISA ) with synthetic peptides . |
| 1.8383 | 10.0068 | 1.0000 | Some of the proteinepitopes were detectable only by immunoblotting with fusion proteins ; others were detectable only by an enzyme-linked immunosorbent assay ( ELISA ) with synthetic peptides . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6163 | 20.9699 | 10.9927 | The carboxy-terminal half of the HBx protein was preferentially recognized by antibodies from patients with chronic hepatitis and contained a short proteinimmunodominant antigenic region with at least two major nonoverlapping epitopes . |
| 2.2785 | 20.2436 | 1.0000 | The carboxy-terminal half of the proteinHBx protein was preferentially recognized by antibodies from patients with chronic hepatitis and contained a short immunodominant antigenic region with at least two major nonoverlapping epitopes . |
| 1.6139 | 10.1510 | 1.0000 | The carboxy-terminal half of the HBx protein was preferentially recognized by proteinantibodies from patients with chronic hepatitis and contained a short immunodominant antigenic region with at least two major nonoverlapping epitopes . |
| 1.5197 | 10.7674 | 0.9999 | The proteincarboxy-terminal half of the HBx protein was preferentially recognized by antibodies from patients with chronic hepatitis and contained a short immunodominant antigenic region with at least two major nonoverlapping epitopes . |
| 3.5361 | 20.9065 | 10.8515 | The carboxy-terminal half of the HBx protein was preferentially recognized by antibodies from patients with chronic hepatitis and contained a short immunodominant antigenic region with at least two proteinmajor nonoverlapping epitopes . |
| 0.5447 | 1.0000 | 1.0000 | The carboxy-terminal half of the HBx protein was preferentially recognized by antibodies from patients with chronic hepatitis and contained a short immunodominant antigenic region with at least two major nonoverlapping proteinepitopes . |
| The carboxy-terminal half of the HBx protein was preferentially recognized by antibodies from patients with chronic hepatitis and contained a short immunodominant antigenic region with at least two major proteinnonoverlapping epitopes . | |||
| The carboxy-terminal half of the proteinHBx protein was preferentially recognized by antibodies from patients with chronic hepatitis and contained a short immunodominant antigenic region with at least two major nonoverlapping epitopes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.6895 | 1.0000 | 0.9998 | Anti- proteinHBx antibody titers as revealed by peptide ELISAs were highest and most frequent in patients with chronic hepatitis and usually low in acutely infected patients and asymptomatic carriers . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7759 | 10.3336 | 1.0000 | The data demonstrate a remarkable qualitative and quantitative heterogeneity of the humoral proteinHBx immune response which can be monitored by HBx -specific peptide ELISAs . |
| 1.7508 | 10.5401 | 1.0000 | The data demonstrate a remarkable qualitative and quantitative heterogeneity of the humoral HBx immune response which can be monitored by proteinHBx -specific peptide ELISAs . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5491 | 10.8781 | 0.9999 | [The inhibitory effect of hydrocortisone on the chemotactic migration of cell_typehuman leukocytes ] |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6834 | 10.6493 | 1.0000 | Random migration ( RM ) and chemotactic migration ( ChtM ) of cell_typehuman leukocytes to yeast activated serum were studied with the modified Boyden chamber method . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9140 | 1.0000 | 1.0000 | cell_typeLeukocytes migrated most rapidly at night. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.7127 | 1.0000 | 1.0000 | The difference between the peak (0:00) and trough values (8:00) of RM and proteinChtM was significant statistically (P less than 0.01). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9860 | 1.0000 | 1.0000 | proteinChtM was inhibited by hydrocortisone (F) of physiological concentration (10(-9)-10(-7) mol/L) which was dose-dependent and completely antagonized by the competitive antagonist , RU38486 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9134 | 1.0000 | 1.0000 | It is suggested that glucocorticoids ( GC ) may be a physiological regulator of the activity of cell_typeleukocytes and its inhibitory action on ChtM may be involved in antiinflammatory mechanisms of GC of pharmacological doses . |
| 1.8221 | 10.3103 | 1.0000 | It is suggested that glucocorticoids ( GC ) may be a physiological regulator of the activity of leukocytes and its inhibitory action on proteinChtM may be involved in antiinflammatory mechanisms of GC of pharmacological doses . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0738 | 20.9108 | 20.9026 | The action of physiological and pharmacological concentration of GC may be mediated by proteinlow affinity specific binding sites of glucocorticoid receptors . |
| 1.4667 | 10.9204 | 0.9997 | The action of physiological and pharmacological concentration of GC may be mediated by low affinity specific binding sites of proteinglucocorticoid receptors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4748 | 20.1175 | 10.5259 | Heterogeneity of antigen molecules recognized by proteinanti-tax1 monoclonal antibody Lt-4 in cell lines bearing human T cell leukemia virus type I and related retroviruses . |
| 1.4411 | 10.8021 | 1.0000 | Heterogeneity of proteinantigen molecules recognized by anti-tax1 monoclonal antibody Lt-4 in cell lines bearing human T cell leukemia virus type I and related retroviruses . |
| 2.0833 | 20.1971 | 0.9997 | Heterogeneity of antigen molecules recognized by proteinanti-tax1 monoclonal antibody Lt-4 in cell lines bearing human T cell leukemia virus type I and related retroviruses . |
| 1.6144 | 10.3568 | 1.0000 | Heterogeneity of antigen molecules recognized by anti-tax1 monoclonal antibody Lt-4 in cell_linecell lines bearing human T cell leukemia virus type I and related retroviruses . |
| Heterogeneity of antigen molecules recognized by anti-tax1 monoclonal antibody proteinLt-4 in cell lines bearing human T cell leukemia virus type I and related retroviruses . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6140 | 10.7094 | 1.0000 | Using a monoclonal antibody , Lt-4 , directed against human T cell leukemia virus type I ( HTLV-I ) trans-activator ( tax1 ) antigen , we examined the expression of proteintax1 and related antigens in a variety of T cell lines bearing HTLV-I and related retroviruses , simian T cell leukemia virus type I ( STLV-I ) and HTLV-II , by immunofluorescence and immunoblot assays . |
| 1.3508 | 20.6713 | 0.9999 | Using a proteinmonoclonal antibody , Lt-4 , directed against human T cell leukemia virus type I ( HTLV-I ) trans-activator ( tax1 ) antigen , we examined the expression of tax1 and related antigens in a variety of T cell lines bearing HTLV-I and related retroviruses , simian T cell leukemia virus type I ( STLV-I ) and HTLV-II , by immunofluorescence and immunoblot assays . |
| 0.9825 | 1.0000 | 0.9790 | Using a monoclonal antibody , Lt-4 , directed against human T cell leukemia virus type I ( HTLV-I ) trans-activator ( proteintax1 ) antigen , we examined the expression of tax1 and related antigens in a variety of T cell lines bearing HTLV-I and related retroviruses , simian T cell leukemia virus type I ( STLV-I ) and HTLV-II , by immunofluorescence and immunoblot assays . |
| 0.9169 | 0.9999 | 1.0000 | Using a monoclonal antibody , proteinLt-4 , directed against human T cell leukemia virus type I ( HTLV-I ) trans-activator ( tax1 ) antigen , we examined the expression of tax1 and related antigens in a variety of T cell lines bearing HTLV-I and related retroviruses , simian T cell leukemia virus type I ( STLV-I ) and HTLV-II , by immunofluorescence and immunoblot assays . |
| 0.7384 | 0.9873 | 0.9963 | Using a monoclonal antibody , Lt-4 , directed against human T cell leukemia virus type I ( HTLV-I ) trans-activator ( tax1 ) antigen , we examined the expression of tax1 and related antigens in a variety of cell_lineT cell lines bearing HTLV-I and related retroviruses , simian T cell leukemia virus type I ( STLV-I ) and HTLV-II , by immunofluorescence and immunoblot assays . |
| Using a monoclonal antibody , Lt-4 , directed against proteinhuman T cell leukemia virus type I ( HTLV-I ) trans-activator ( tax1 ) antigen , we examined the expression of tax1 and related antigens in a variety of T cell lines bearing HTLV-I and related retroviruses , simian T cell leukemia virus type I ( STLV-I ) and HTLV-II , by immunofluorescence and immunoblot assays . | |||
| Using a monoclonal antibody , Lt-4 , directed against proteinhuman T cell leukemia virus type I ( HTLV-I ) trans-activator ( tax1 ) antigen , we examined the expression of tax1 and related antigens in a variety of T cell lines bearing HTLV-I and related retroviruses , simian T cell leukemia virus type I ( STLV-I ) and HTLV-II , by immunofluorescence and immunoblot assays . | |||
| Using a monoclonal antibody , Lt-4 , directed against human T cell leukemia virus type I ( HTLV-I ) trans-activator ( tax1 ) antigen , we examined the expression of tax1 and related proteinantigens in a variety of T cell lines bearing HTLV-I and related retroviruses , simian T cell leukemia virus type I ( STLV-I ) and HTLV-II , by immunofluorescence and immunoblot assays . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0490 | 20.9964 | 10.8062 | Lt-4 reacted with all HTLV-I -bearing cell lines tested and five out of eight simian cell lines bearing STLV-I , but not with an cell_lineHTLV-II -bearing cell line . |
| 3.8978 | 20.5606 | 10.8953 | Lt-4 reacted with all cell_lineHTLV-I -bearing cell lines tested and five out of eight simian cell lines bearing STLV-I , but not with an HTLV-II -bearing cell line . |
| 3.6956 | 20.5421 | 10.7379 | Lt-4 reacted with all HTLV-I -bearing cell lines tested and five out of eight cell_linesimian cell lines bearing STLV-I , but not with an HTLV-II -bearing cell line . |
| 0.9638 | 1.0000 | 1.0000 | proteinLt-4 reacted with all HTLV-I -bearing cell lines tested and five out of eight simian cell lines bearing STLV-I , but not with an HTLV-II -bearing cell line . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8786 | 30.9207 | 10.7214 | Lt-4 detected 40 kd tax1 antigen molecules in most cell_lineHTLV-I -bearing cell lines except one cell line that expressed 39 kd tax1 antigen . |
| 3.9890 | 30.5884 | 10.4108 | Lt-4 detected 40 kd tax1 antigen molecules in most HTLV-I -bearing cell lines except one cell line that expressed protein39 kd tax1 antigen . |
| 0.9336 | 1.0000 | 1.0000 | proteinLt-4 detected 40 kd tax1 antigen molecules in most HTLV-I -bearing cell lines except one cell line that expressed 39 kd tax1 antigen . |
| 3.8664 | 20.1534 | 20.2734 | Lt-4 detected protein40 kd tax1 antigen molecules in most HTLV-I -bearing cell lines except one cell line that expressed 39 kd tax1 antigen . |
| Lt-4 detected 40 kd proteintax1 antigen molecules in most HTLV-I -bearing cell lines except one cell line that expressed 39 kd tax1 antigen . | |||
| Lt-4 detected 40 kd proteintax1 antigen molecules in most HTLV-I -bearing cell lines except one cell line that expressed 39 kd tax1 antigen . | |||
| Lt-4 detected 40 kd tax1 antigen molecules in most HTLV-I -bearing cell lines except one cell line that expressed 39 kd proteintax1 antigen . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.5950 | 20.5086 | 20.9913 | In the cell_lineSTLV-I -bearing T cell lines , tax1 -related antigen molecules detected by Lt-4 were heterogeneous, having molecular weights in the range of 36-41 kd. |
| 4.0112 | 20.8286 | 10.6848 | In the STLV-I -bearing T cell lines , proteintax1 -related antigen molecules detected by Lt-4 were heterogeneous, having molecular weights in the range of 36-41 kd. |
| 1.6669 | 10.1201 | 0.9956 | In the STLV-I -bearing T cell lines , proteintax1 -related antigen molecules detected by Lt-4 were heterogeneous, having molecular weights in the range of 36-41 kd. |
| 0.8411 | 1.0000 | 1.0000 | In the STLV-I -bearing T cell lines , tax1 -related antigen molecules detected by proteinLt-4 were heterogeneous, having molecular weights in the range of 36-41 kd. |
| In the STLV-I -bearing cell_lineT cell lines , tax1 -related antigen molecules detected by Lt-4 were heterogeneous, having molecular weights in the range of 36-41 kd. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.3853 | 30.0178 | 30.2250 | Characterization of the proteinhuman immunodeficiency virus type 1 enhancer -binding proteins from the human T-cell line Jurkat . |
| 4.2014 | 30.5784 | 10.7919 | Characterization of the human immunodeficiency virus type 1 enhancer -binding proteins from the cell_linehuman T-cell line Jurkat . |
| Characterization of the DNAhuman immunodeficiency virus type 1 enhancer -binding proteins from the human T-cell line Jurkat . | |||
| Characterization of the human immunodeficiency virus type 1 enhancer -binding proteins from the cell_linehuman T-cell line Jurkat . | |||
| Characterization of the human immunodeficiency virus type 1 enhancer -binding proteins from the human T-cell line cell_lineJurkat . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2769 | 20.8138 | 10.7681 | The transcription of the human immunodeficiency virus type 1 ( HIV-1 ) is under the control of cellular proteins that bind to the DNAviral long terminal repeat ( LTR ). |
| 1.5418 | 10.9295 | 1.0000 | The transcription of the human immunodeficiency virus type 1 ( HIV-1 ) is under the control of proteincellular proteins that bind to the viral long terminal repeat ( LTR ). |
| 0.9364 | 1.0000 | 1.0000 | The transcription of the human immunodeficiency virus type 1 ( HIV-1 ) is under the control of cellular proteins that bind to the viral long terminal repeat ( DNALTR ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3971 | 10.9792 | 0.9998 | Among the protein-binding regions of the HIV-1 LTR is the DNAtranscription-enhancer region . |
| 1.3618 | 10.9171 | 0.9999 | Among the protein-binding regions of the DNAHIV-1 LTR is the transcription-enhancer region . |
| 1.3526 | 10.7480 | 0.9999 | Among the proteinprotein-binding regions of the HIV-1 LTR is the transcription-enhancer region . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2197 | 20.2579 | 0.9999 | We show that at least one inducible , C1 , and one constitutive, C2 , protein can bind to the DNAHIV enhancer in Jurkat cells . |
| 1.6860 | 10.5149 | 1.0000 | We show that at least one inducible , proteinC1 , and one constitutive, C2 , protein can bind to the HIV enhancer in Jurkat cells . |
| 1.6170 | 10.8190 | 0.9998 | We show that at least one inducible , C1 , and one constitutive, C2 , protein can bind to the HIV enhancer in cell_lineJurkat cells . |
| 0.9134 | 1.0000 | 1.0000 | We show that at least one inducible , C1 , and one constitutive, proteinC2 , protein can bind to the HIV enhancer in Jurkat cells . |
| We show that at least one proteininducible , C1 , and one constitutive, C2 , protein can bind to the HIV enhancer in Jurkat cells . | |||
| We show that at least one inducible , C1 , and one proteinconstitutive, C2 , protein can bind to the HIV enhancer in Jurkat cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4041 | 20.4713 | 0.9999 | Bivalent cations such as Mg2+ and Zn2+ differentially affect their binding to oligonucleotides which contain the DNAHIV-enhancer domain . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9651 | 20.9771 | 10.7526 | Both C1 and C2 proteins also bind to a similar sequence found in the DNAinterleukin-2 -receptor alpha-subunit enhancer . |
| 2.1543 | 20.2212 | 0.9972 | Both C1 and C2 proteins also bind to a similar sequence found in the proteininterleukin-2 -receptor alpha-subunit enhancer . |
| 0.8765 | 1.0000 | 1.0000 | Both proteinC1 and C2 proteins also bind to a similar sequence found in the interleukin-2 -receptor alpha-subunit enhancer . |
| 0.7514 | 0.9960 | 0.9999 | Both C1 and proteinC2 proteins also bind to a similar sequence found in the interleukin-2 -receptor alpha-subunit enhancer . |
| Both C1 and C2 proteins also bind to a similar sequence found in the proteininterleukin-2 -receptor alpha-subunit enhancer . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9501 | 20.9378 | 10.9760 | The inducible C1 protein was partially purified by three chromatographic steps and characterized by u.v. cross-linking as a protein47 kDa protein . |
| 2.2549 | 20.5532 | 1.0000 | The inducible proteinC1 protein was partially purified by three chromatographic steps and characterized by u.v. cross-linking as a 47 kDa protein . |
| The proteininducible C1 protein was partially purified by three chromatographic steps and characterized by u.v. cross-linking as a 47 kDa protein . | |||
| The inducible proteinC1 protein was partially purified by three chromatographic steps and characterized by u.v. cross-linking as a 47 kDa protein . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4405 | 10.9309 | 1.0000 | Differences in DNAtranscriptional enhancers of HIV-1 and HIV-2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Response to cell_typeT cell activation signals . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| cell_typeT cell activation results in high levels of HIV replication and is thought to be one mechanism leading to the conversion from latent to active viral infection . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.2415 | 30.0349 | 10.4828 | In HIV-1 , the sequences that respond to these signaling events are found in the long terminal repeat ( LTR ) and comprise the transcriptional enhancer , which contains two conserved binding sites for the proteinnuclear factor kappa B ( NF kappa B ). |
| 4.0455 | 20.8621 | 10.6820 | In HIV-1 , the sequences that respond to these signaling events are found in the long terminal repeat ( LTR ) and comprise the transcriptional enhancer , which contains two DNAconserved binding sites for the nuclear factor kappa B ( NF kappa B ). |
| 3.9441 | 20.7396 | 10.6344 | In HIV-1 , the sequences that respond to these signaling events are found in the long terminal repeat ( LTR ) and comprise the transcriptional enhancer , which contains two conserved binding sites for the nuclear factor kappa B ( proteinNF kappa B ). |
| 3.5211 | 20.7428 | 10.8391 | In HIV-1 , the sequences that respond to these signaling events are found in the DNAlong terminal repeat ( LTR ) and comprise the transcriptional enhancer , which contains two conserved binding sites for the nuclear factor kappa B ( NF kappa B ). |
| 2.0654 | 20.2623 | 1.0000 | In HIV-1 , the sequences that respond to these signaling events are found in the long terminal repeat ( LTR ) and comprise the DNAtranscriptional enhancer , which contains two conserved binding sites for the nuclear factor kappa B ( NF kappa B ). |
| 0.9524 | 1.0000 | 1.0000 | In HIV-1 , the sequences that respond to these signaling events are found in the long terminal repeat ( DNALTR ) and comprise the transcriptional enhancer , which contains two conserved binding sites for the nuclear factor kappa B ( NF kappa B ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1127 | 20.7390 | 10.9582 | The corresponding region in the second AIDS retrovirus , HIV-2 , contains a conserved and a divergent DNANF kappa B binding site . |
| 3.2183 | 20.9643 | 10.9526 | The corresponding region in the second AIDS retrovirus , HIV-2 , contains a conserved and a divergent proteinNF kappa B binding site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2947 | 20.2056 | 1.0000 | We demonstrate that the HIV-1 LTR responds better than the DNAHIV-2 LTR to T cell activation signals. |
| 2.2919 | 20.1200 | 0.9999 | We demonstrate that the DNAHIV-1 LTR responds better than the HIV-2 LTR to T cell activation signals. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7313 | 10.5361 | 1.0000 | These qualitative differences in the response to T cell activation are reproduced not only when HIV-1 or HIV-2 enhancers are placed upstream of a DNAheterologous promoter but also when these enhancers are switched between their respective LTR . |
| 0.8841 | 1.0000 | 1.0000 | These qualitative differences in the response to T cell activation are reproduced not only when HIV-1 or HIV-2 enhancers are placed upstream of a heterologous promoter but also when these enhancers are switched between their respective DNALTR . |
| 0.7377 | 1.0000 | 1.0000 | These qualitative differences in the response to T cell activation are reproduced not only when HIV-1 or HIV-2 enhancers are placed upstream of a heterologous promoter but also when these DNAenhancers are switched between their respective LTR . |
| These qualitative differences in the response to cell_typeT cell activation are reproduced not only when HIV-1 or HIV-2 enhancers are placed upstream of a heterologous promoter but also when these enhancers are switched between their respective LTR . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6048 | 20.8111 | 10.7573 | In electrophoretic mobility shift assays, NF kappa B binds to both conserved sites in the DNAHIV-1 transcriptional enhancer and only to the single conserved site in the HIV-2 transcriptional enhancer . |
| 3.5730 | 20.7379 | 10.9688 | In electrophoretic mobility shift assays, NF kappa B binds to both conserved sites in the HIV-1 transcriptional enhancer and only to the single conserved site in the DNAHIV-2 transcriptional enhancer . |
| 2.1118 | 20.5732 | 10.0399 | In electrophoretic mobility shift assays, proteinNF kappa B binds to both conserved sites in the HIV-1 transcriptional enhancer and only to the single conserved site in the HIV-2 transcriptional enhancer . |
| 2.0601 | 20.0780 | 0.9999 | In electrophoretic mobility shift assays, NF kappa B binds to both conserved sites in the HIV-1 transcriptional enhancer and only to the single DNAconserved site in the HIV-2 transcriptional enhancer . |
| 1.3851 | 10.9676 | 0.9998 | In electrophoretic mobility shift assays, NF kappa B binds to both DNAconserved sites in the HIV-1 transcriptional enhancer and only to the single conserved site in the HIV-2 transcriptional enhancer . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0040 | 20.2649 | 10.5744 | Instead of proteinNF kappa B , the activator protein 3 binds to the divergent site in HIV-2 . |
| 3.4000 | 20.2320 | 10.7174 | Instead of NF kappa B , the proteinactivator protein 3 binds to the divergent site in HIV-2 . |
| 2.0105 | 20.4829 | 0.9999 | Instead of NF kappa B , the activator protein 3 binds to the DNAdivergent site in HIV-2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.7149 | 10.6290 | 10.5181 | NF-X2 that binds to the DRA X2-box is proteinactivator protein 1 . |
| 1.2543 | 10.7677 | 0.9996 | NF-X2 that binds to the DNADRA X2-box is activator protein 1 . |
| 0.9068 | 1.0000 | 1.0000 | proteinNF-X2 that binds to the DRA X2-box is activator protein 1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.2371 | 10.3260 | 1.0000 | Expression cloning of proteinc-Jun . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8802 | 20.8695 | 10.5375 | Human class II MHC Ag are a family of proteincell surface glycoproteins . |
| 2.4073 | 0.9992 | 20.6562 | proteinHuman class II MHC Ag are a family of cell surface glycoproteins . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.7344 | 10.8696 | 10.9884 | Their constitutive expression is limited to B lymphocytes and cell_typethymic epithelial cells . |
| 1.2774 | 10.8579 | 0.9994 | Their constitutive expression is limited to cell_typeB lymphocytes and thymic epithelial cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5690 | 10.9267 | 1.0000 | In many other cells their expression can be induced by proteinIFN-gamma . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3241 | 20.7678 | 10.4933 | Conserved upstream promoter sequences regulate this tissue-specific expression of DNAclass II genes . |
| 2.6905 | 10.8237 | 10.5207 | Conserved DNAupstream promoter sequences regulate this tissue-specific expression of class II genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2267 | 20.9413 | 10.8058 | In the DRA promoter , one of these cis-acting regulatory motifs is the X2-box to which proteinnuclear factor X2 ( NF-X2 ) binds. |
| 3.9437 | 20.8168 | 10.8492 | In the DRA promoter , one of these DNAcis-acting regulatory motifs is the X2-box to which nuclear factor X2 ( NF-X2 ) binds. |
| 2.1332 | 20.1449 | 1.0000 | In the DRA promoter , one of these cis-acting regulatory motifs is the DNAX2-box to which nuclear factor X2 ( NF-X2 ) binds. |
| 1.3303 | 20.9372 | 0.9999 | In the DNADRA promoter , one of these cis-acting regulatory motifs is the X2-box to which nuclear factor X2 ( NF-X2 ) binds. |
| 0.9590 | 1.0000 | 0.9999 | In the DRA promoter , one of these cis-acting regulatory motifs is the X2-box to which nuclear factor X2 ( proteinNF-X2 ) binds. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7216 | 20.5438 | 10.5418 | Here, we present the isolation and characterization of the DNAfull-length cDNA clone encoding NF-X2 . |
| 0.8729 | 0.9999 | 1.0000 | Here, we present the isolation and characterization of the full-length cDNA clone encoding proteinNF-X2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.3299 | 30.1432 | 10.7262 | This cDNA clone was isolated by expression cDNA cloning , and encodes the human c-Jun protein , which together with c-Fos forms the proteinheterodimeric activator protein-1 transcription complex . |
| 2.1995 | 20.5719 | 0.9999 | This cDNA clone was isolated by expression cDNA cloning , and encodes the proteinhuman c-Jun protein , which together with c-Fos forms the heterodimeric activator protein-1 transcription complex . |
| 1.3788 | 10.8373 | 0.9999 | This DNAcDNA clone was isolated by expression cDNA cloning , and encodes the human c-Jun protein , which together with c-Fos forms the heterodimeric activator protein-1 transcription complex . |
| 1.3658 | 10.0393 | 1.0000 | This cDNA clone was isolated by expression cDNA cloning , and encodes the human c-Jun protein , which together with proteinc-Fos forms the heterodimeric activator protein-1 transcription complex . |
| 0.8569 | 1.0000 | 0.9871 | This cDNA clone was isolated by expression cDNA cloning , and encodes the human proteinc-Jun protein , which together with c-Fos forms the heterodimeric activator protein-1 transcription complex . |
| This cDNA clone was isolated by expression DNAcDNA cloning , and encodes the human c-Jun protein , which together with c-Fos forms the heterodimeric activator protein-1 transcription complex . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0928 | 10.5105 | 10.7668 | Whereas proteinc-Fos /c-Jun heterodimers do not exist in B cells , they form and bind to the X2-box in class II nonexpressing cells . |
| 1.4069 | 10.8301 | 0.9999 | Whereas c-Fos /c-Jun heterodimers do not exist in B cells , they form and bind to the DNAX2-box in class II nonexpressing cells . |
| 0.6797 | 0.9999 | 0.9937 | Whereas proteinc-Fos /c-Jun heterodimers do not exist in B cells , they form and bind to the X2-box in class II nonexpressing cells . |
| 4.5286 | 20.4637 | 10.2439 | Whereas c-Fos /c-Jun heterodimers do not exist in B cells , they form and bind to the X2-box in cell_typeclass II nonexpressing cells . |
| 1.9541 | 20.8028 | 0.9998 | Whereas c-Fos /c-Jun heterodimers do not exist in cell_typeB cells , they form and bind to the X2-box in class II nonexpressing cells . |
| Whereas c-Fos /c-Jun heterodimers do not exist in cell_lineB cells , they form and bind to the X2-box in class II nonexpressing cells . | |||
| Whereas c-Fos /c-Jun heterodimers do not exist in B cells , they form and bind to the X2-box in cell_lineclass II nonexpressing cells . | |||
| Whereas c-Fos protein/c-Jun heterodimers do not exist in B cells , they form and bind to the X2-box in class II nonexpressing cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1150 | 10.8077 | 10.1779 | Thus, proteinc-Fos /c-Jun heterodimers might contribute to the repression of DRA gene expression . |
| 2.0119 | 20.6797 | 0.9999 | Thus, c-Fos /c-Jun heterodimers might contribute to the repression of DNADRA gene expression . |
| 0.6747 | 0.9999 | 0.9953 | Thus, proteinc-Fos /c-Jun heterodimers might contribute to the repression of DRA gene expression . |
| Thus, c-Fos protein/c-Jun heterodimers might contribute to the repression of DRA gene expression . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8706 | 10.9804 | 10.5831 | Radioreceptor assay of some corticosteroid derivatives in cell_typehuman mononuclear leukocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5843 | 20.4239 | 10.7105 | Several new 4,19-substituted steroids and previously synthesized corticosteroids were assayed for affinity to proteintype 1 receptors in human mononuclear leukocytes . |
| 2.9757 | 10.9551 | 10.4905 | Several new 4,19-substituted steroids and previously synthesized corticosteroids were assayed for affinity to type 1 receptors in cell_typehuman mononuclear leukocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9386 | 20.8004 | 10.3941 | When tested in a radioreceptor assay in human mononuclear leukocytes the synthesized compounds showed only low relative binding affinities ( RBA ) to proteintype 1 receptor , the highest being 0.72% for 13 ( aldosterone = 100%). |
| 3.0652 | 30.0654 | 10.7278 | When tested in a radioreceptor assay in cell_typehuman mononuclear leukocytes the synthesized compounds showed only low relative binding affinities ( RBA ) to type 1 receptor , the highest being 0.72% for 13 ( aldosterone = 100%). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9332 | 1.0000 | 1.0000 | For comparison, other proteinRBA in this system were: 19-noraldosterone , 20%; 18-deoxyaldosterone , 5.8%; 18-deoxy-19-noraldosterone , 4.7%; 18,21-anhydroaldosterone , 0.37%; 17-isoaldosterone , 7.6% and apoaldosterone , 4.3% |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1377 | 20.9584 | 0.9998 | Cell type specificity and activation requirements for NFAT-1 ( nuclear factor of activated T-cells ) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual proteinnuclear factor . |
| 1.4786 | 10.9753 | 1.0000 | Cell type specificity and activation requirements for proteinNFAT-1 ( nuclear factor of activated T-cells ) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor . |
| 5.0420 | 30.4423 | 20.8982 | Cell type specificity and activation requirements for NFAT-1 ( proteinnuclear factor of activated T-cells ) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor . |
| Cell type specificity and activation requirements for NFAT-1 ( nuclear factor of cell_typeactivated T-cells ) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor . | |||
| Cell type specificity and activation requirements for NFAT-1 ( proteinnuclear factor of activated T-cells ) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9390 | 20.8680 | 1.0000 | Nuclear factor of activated T-cells ( NFAT-1 ) is a proteintranscription factor which is considered to be an important regulator in early T-cell activation . |
| 0.9791 | 1.0000 | 1.0000 | Nuclear factor of activated T-cells ( proteinNFAT-1 ) is a transcription factor which is considered to be an important regulator in early T-cell activation . |
| 2.4029 | 0.9995 | 20.5539 | proteinNuclear factor of activated T-cells ( NFAT-1 ) is a transcription factor which is considered to be an important regulator in early T-cell activation . |
| proteinNuclear factor of activated T-cells ( NFAT-1 ) is a transcription factor which is considered to be an important regulator in early T-cell activation . | |||
| Nuclear factor of cell_typeactivated T-cells ( NFAT-1 ) is a transcription factor which is considered to be an important regulator in early T-cell activation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5234 | 20.1680 | 1.0000 | We have developed a system to monitor the transcriptional activity of proteinNFAT-1 at the single cell level in whole animals . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9134 | 1.0000 | 0.9964 | The system is based on the use of an oligomerized proteinNFAT-1 binding motif that directs transcription of SV40 T-antigen in transgenic mice . |
| 3.9887 | 20.8308 | 10.7168 | The system is based on the use of an DNAoligomerized NFAT-1 binding motif that directs transcription of SV40 T-antigen in transgenic mice . |
| 1.7836 | 20.7408 | 1.0000 | The system is based on the use of an oligomerized NFAT-1 binding motif that directs transcription of proteinSV40 T-antigen in transgenic mice . |
| The system is based on the use of an oligomerized NFAT-1 binding motif that directs proteintranscription of SV40 T-antigen in transgenic mice . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5601 | 20.7522 | 10.8654 | This report represents the first demonstration that a proteinmultimerized short binding motif can function appropriately in transgenic mice . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8408 | 20.8207 | 10.1225 | NFAT-1 activity had previously been thought to be confined to cell_typeactivated T-lymphocytes upon release of intracellular calcium . |
| 0.9615 | 1.0000 | 1.0000 | proteinNFAT-1 activity had previously been thought to be confined to activated T-lymphocytes upon release of intracellular calcium . |
| NFAT-1 activity had previously been thought to be confined to activated T-lymphocytes upon release of cell_typeintracellular calcium . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7209 | 10.8370 | 1.0000 | By targeting proteinNFAT-1 -dependent gene expression in transgenic mice we discovered new sites of NFAT-1 activity . |
| 1.6331 | 10.8190 | 1.0000 | By targeting NFAT-1 -dependent gene expression in transgenic mice we discovered new sites of proteinNFAT-1 activity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4731 | 20.9864 | 10.8496 | Besides in T-lymphocytes NFAT-1 activity could also be induced in T-lymphocyte-depleted spleen cells and purified B-lymphocytes and requires agents that both release intracellular calcium and activate proteinprotein kinase C . |
| 1.4459 | 10.9593 | 0.9996 | Besides in cell_typeT-lymphocytes NFAT-1 activity could also be induced in T-lymphocyte-depleted spleen cells and purified B-lymphocytes and requires agents that both release intracellular calcium and activate protein kinase C . |
| 0.9202 | 1.0000 | 1.0000 | Besides in T-lymphocytes proteinNFAT-1 activity could also be induced in T-lymphocyte-depleted spleen cells and purified B-lymphocytes and requires agents that both release intracellular calcium and activate protein kinase C . |
| 3.2884 | 20.5266 | 10.6901 | Besides in T-lymphocytes NFAT-1 activity could also be induced in cell_lineT-lymphocyte-depleted spleen cells and purified B-lymphocytes and requires agents that both release intracellular calcium and activate protein kinase C . |
| 1.1256 | 10.5856 | 0.9992 | Besides in T-lymphocytes NFAT-1 activity could also be induced in T-lymphocyte-depleted spleen cells and cell_linepurified B-lymphocytes and requires agents that both release intracellular calcium and activate protein kinase C . |
| Besides in T-lymphocytes NFAT-1 activity could also be induced in cell_typeT-lymphocyte-depleted spleen cells and purified B-lymphocytes and requires agents that both release intracellular calcium and activate protein kinase C . | |||
| Besides in T-lymphocytes NFAT-1 activity could also be induced in T-lymphocyte-depleted spleen cells and cell_typepurified B-lymphocytes and requires agents that both release intracellular calcium and activate protein kinase C . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5672 | 10.5842 | 1.0000 | A difference in the time course of appearance of NFAT-1 activity between cell_typeT-lymphocytes and non-T-lymphocytes was revealed. |
| 1.5442 | 10.7960 | 1.0000 | A difference in the time course of appearance of proteinNFAT-1 activity between T-lymphocytes and non-T-lymphocytes was revealed. |
| 0.8656 | 0.9999 | 1.0000 | A difference in the time course of appearance of NFAT-1 activity between T-lymphocytes and cell_typenon-T-lymphocytes was revealed. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7930 | 10.7037 | 1.0000 | Interestingly, the tissue pattern of expression of the proteinNFAT-1 activity resembles the expression pattern described for HIV-LTR/tat transgenic mice (Vogel, J., Hinrichs, S. H., Reynolds, R. K., Luciw, P. A., and Jay, G. (1988) Nature 335, 606-611). |
| 1.2709 | 10.1710 | 1.0000 | Interestingly, the tissue pattern of expression of the NFAT-1 activity resembles the expression pattern described for DNAHIV-LTR/tat transgenic mice (Vogel, J., Hinrichs, S. H., Reynolds, R. K., Luciw, P. A., and Jay, G. (1988) Nature 335, 606-611). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6553 | 10.3691 | 1.0000 | This similarity in expression and the fact that NFAT-1 has been shown to bind functional sequences in HIV-LTR suggest a role for proteinNFAT-1 in dermal activation of the HIV-LTR . |
| 1.6548 | 10.5540 | 1.0000 | This similarity in expression and the fact that proteinNFAT-1 has been shown to bind functional sequences in HIV-LTR suggest a role for NFAT-1 in dermal activation of the HIV-LTR . |
| 1.5664 | 10.6499 | 1.0000 | This similarity in expression and the fact that NFAT-1 has been shown to bind functional sequences in HIV-LTR suggest a role for NFAT-1 in dermal activation of the DNAHIV-LTR . |
| 1.5485 | 10.8614 | 0.9999 | This similarity in expression and the fact that NFAT-1 has been shown to bind DNAfunctional sequences in HIV-LTR suggest a role for NFAT-1 in dermal activation of the HIV-LTR . |
| 0.8889 | 1.0000 | 1.0000 | This similarity in expression and the fact that NFAT-1 has been shown to bind functional sequences in DNAHIV-LTR suggest a role for NFAT-1 in dermal activation of the HIV-LTR . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.1751 | 30.6166 | 20.6394 | A novel T-cell protein which recognizes a palindromic sequence in the negative regulatory element of the DNAhuman immunodeficiency virus long terminal repeat . |
| 3.5920 | 20.7198 | 10.8930 | A novel T-cell protein which recognizes a palindromic sequence in the DNAnegative regulatory element of the human immunodeficiency virus long terminal repeat . |
| 1.7538 | 20.3963 | 0.9999 | A novel T-cell protein which recognizes a DNApalindromic sequence in the negative regulatory element of the human immunodeficiency virus long terminal repeat . |
| 1.3138 | 10.5815 | 0.9991 | A proteinnovel T-cell protein which recognizes a palindromic sequence in the negative regulatory element of the human immunodeficiency virus long terminal repeat . |
| A novel proteinT-cell protein which recognizes a palindromic sequence in the negative regulatory element of the human immunodeficiency virus long terminal repeat . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.2969 | 30.9175 | 20.6221 | Two major protein-binding sites within the negative regulatory element of the DNAhuman immunodeficiency virus type 1 long terminal repeat have been identified. |
| 2.9722 | 20.2840 | 10.6575 | Two major protein-binding sites within the DNAnegative regulatory element of the human immunodeficiency virus type 1 long terminal repeat have been identified. |
| 1.7424 | 20.5653 | 0.9999 | Two major DNAprotein-binding sites within the negative regulatory element of the human immunodeficiency virus type 1 long terminal repeat have been identified. |
| Two DNAmajor protein-binding sites within the negative regulatory element of the human immunodeficiency virus type 1 long terminal repeat have been identified. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8750 | 20.6766 | 10.9061 | One ( site B ) contained a palindromic sequence with homology to DNAsteroid/thyroid hormone response elements but was distinct from previously described binding sites of this class. |
| 1.4236 | 10.9039 | 0.9999 | One ( DNAsite B ) contained a palindromic sequence with homology to steroid/thyroid hormone response elements but was distinct from previously described binding sites of this class. |
| 1.2988 | 10.9772 | 1.0000 | One ( site B ) contained a DNApalindromic sequence with homology to steroid/thyroid hormone response elements but was distinct from previously described binding sites of this class. |
| 1.4020 | 10.7781 | 0.9999 | One ( site B ) contained a palindromic sequence with homology to steroid/thyroid hormone response elements but was distinct from previously described DNAbinding sites of this class. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6261 | 10.5430 | 1.0000 | A novel proteinT-cell protein recognized the palindromic sequence within site B and also bound estrogen- or thyroid hormone- response elements with lower affinity. |
| 1.5674 | 10.7152 | 0.9999 | A novel T-cell protein recognized the palindromic sequence within DNAsite B and also bound estrogen- or thyroid hormone- response elements with lower affinity. |
| 1.4546 | 10.9558 | 0.9999 | A novel T-cell protein recognized the DNApalindromic sequence within site B and also bound estrogen- or thyroid hormone- response elements with lower affinity. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.4727 | 30.7320 | 20.1418 | A 7-base-pair mutation in the site B palindrome , which destroyed protein binding, resulted in increased expression from the DNAhuman immunodeficiency virus type 1 long terminal repeat in T cells . |
| 4.1009 | 30.5306 | 10.7953 | A 7-base-pair mutation in the DNAsite B palindrome , which destroyed protein binding, resulted in increased expression from the human immunodeficiency virus type 1 long terminal repeat in T cells . |
| 1.4258 | 10.8413 | 0.9990 | A 7-base-pair mutation in the site B palindrome , which destroyed protein binding, resulted in increased expression from the human immunodeficiency virus type 1 long terminal repeat in cell_typeT cells . |
| A 7-base-pair mutation in the DNAsite B palindrome , which destroyed protein binding, resulted in increased expression from the human immunodeficiency virus type 1 long terminal repeat in T cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2401 | 20.2225 | 1.0000 | Progesterone suppression of cell_typepregnancy lymphocytes is not mediated by glucocorticoid effect. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3164 | 20.1538 | 1.0000 | This study investigated whether the suppressive effect of progesterone on cell_typepregnancy lymphocytes is mediated by specific progesterone receptors . |
| 2.2547 | 20.3675 | 0.9999 | This study investigated whether the suppressive effect of progesterone on pregnancy lymphocytes is mediated by specific proteinprogesterone receptors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2690 | 20.5893 | 0.9998 | The effects of a competitive progesterone antagonist ( RU486 ) and a specific proteinglucocorticoid receptor blocker ( RU43044 ) were tested on the release of a blocking factor by progesterone -treated pregnancy lymphocytes . |
| 2.1235 | 20.2971 | 0.9999 | The effects of a competitive progesterone antagonist ( RU486 ) and a specific glucocorticoid receptor blocker ( RU43044 ) were tested on the release of a proteinblocking factor by progesterone -treated pregnancy lymphocytes . |
| 1.6906 | 0.9998 | 10.4090 | The effects of a competitive progesterone antagonist ( RU486 ) and a specific glucocorticoid receptor blocker ( RU43044 ) were tested on the release of a blocking factor by progesterone -treated cell_typepregnancy lymphocytes . |
| 2.2146 | 20.3895 | 10.3164 | The effects of a competitive progesterone antagonist ( RU486 ) and a specific glucocorticoid receptor blocker ( RU43044 ) were tested on the release of a blocking factor by cell_typeprogesterone -treated pregnancy lymphocytes . |
| The effects of a competitive progesterone antagonist ( RU486 ) and a specific glucocorticoid receptor blocker ( RU43044 ) were tested on the release of a blocking factor by cell_lineprogesterone -treated pregnancy lymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5060 | 20.4505 | 1.0000 | RU 486 tested at an equal concentration as progesterone significantly inhibited the production of the proteinblocking factor , while RU 43044 was without effect. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0037 | 10.6974 | 10.4652 | These data suggest that in pregnancy, lymphocyte progesterone acts on specific progesterone receptors and proteinglucocorticoid binding sites are not involved. |
| 2.1686 | 20.0153 | 0.9999 | These data suggest that in pregnancy, lymphocyte progesterone acts on specific proteinprogesterone receptors and glucocorticoid binding sites are not involved. |
| 0.7306 | 0.9997 | 0.9999 | These data suggest that in pregnancy, cell_typelymphocyte progesterone acts on specific progesterone receptors and glucocorticoid binding sites are not involved. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6256 | 10.9003 | 1.0000 | The protein56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90- kilodalton heat shock proteins . |
| 3.9291 | 20.3283 | 10.9834 | The 56-59-kilodalton protein identified in untransformed proteinsteroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90- kilodalton heat shock proteins . |
| The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a proteinunique protein that exists in cytosol in a complex with both the 70- and 90- kilodalton heat shock proteins . | |||
| The 56-59-kilodalton protein identified in proteinuntransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90- kilodalton heat shock proteins . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4094 | 20.2588 | 1.0000 | It has previously been shown that 9S , untransformed progestin , estrogen , androgen , and glucocorticoid receptor complexes in rabbit uterine and liver cytosols contain a protein59-kDa protein [Tai, P.K., Maeda, Y., Nakao, K., Wakim, N.G., Duhring, J.L., & Faber, L.E.(1986) Biochemistry 25, 5269-5275]. |
| 0.9428 | 1.0000 | 1.0000 | It has previously been shown that protein9S , untransformed progestin , estrogen , androgen , and glucocorticoid receptor complexes in rabbit uterine and liver cytosols contain a 59-kDa protein [Tai, P.K., Maeda, Y., Nakao, K., Wakim, N.G., Duhring, J.L., & Faber, L.E.(1986) Biochemistry 25, 5269-5275]. |
| 4.7713 | 30.0227 | 10.6476 | It has previously been shown that 9S , untransformed progestin , estrogen , androgen , and proteinglucocorticoid receptor complexes in rabbit uterine and liver cytosols contain a 59-kDa protein [Tai, P.K., Maeda, Y., Nakao, K., Wakim, N.G., Duhring, J.L., & Faber, L.E.(1986) Biochemistry 25, 5269-5275]. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2359 | 20.9379 | 10.8210 | In this work we show that the proteinmonoclonal antibody KN 382/EC1 raised against the rabbit 59-kDa protein reacts with 9S , untransformed glucocorticoid receptor complexes in cytosol prepared from human IM-9 lymphocytes but not with 4S salt-transformed receptors . |
| 4.1342 | 20.9728 | 10.8933 | In this work we show that the monoclonal antibody KN 382/EC1 raised against the rabbit 59-kDa protein reacts with 9S , untransformed glucocorticoid receptor complexes in cytosol prepared from human IM-9 lymphocytes but not with protein4S salt-transformed receptors . |
| 3.4959 | 20.6212 | 10.8343 | In this work we show that the monoclonal antibody KN 382/EC1 raised against the rabbit 59-kDa protein reacts with 9S , untransformed glucocorticoid receptor complexes in cytosol prepared from cell_linehuman IM-9 lymphocytes but not with 4S salt-transformed receptors . |
| 3.4088 | 20.2526 | 10.7838 | In this work we show that the monoclonal antibody KN 382/EC1 raised against the proteinrabbit 59-kDa protein reacts with 9S , untransformed glucocorticoid receptor complexes in cytosol prepared from human IM-9 lymphocytes but not with 4S salt-transformed receptors . |
| 5.9342 | 30.5268 | 20.6879 | In this work we show that the monoclonal antibody KN 382/EC1 raised against the rabbit 59-kDa protein reacts with protein9S , untransformed glucocorticoid receptor complexes in cytosol prepared from human IM-9 lymphocytes but not with 4S salt-transformed receptors . |
| 1.5330 | 0.9995 | 10.0808 | In this work we show that the monoclonal antibody KN 382/EC1 raised against the rabbit 59-kDa protein reacts with 9S , untransformed proteinglucocorticoid receptor complexes in cytosol prepared from human IM-9 lymphocytes but not with 4S salt-transformed receptors . |
| 0.7805 | 0.9994 | 0.9999 | In this work we show that the monoclonal antibody proteinKN 382/EC1 raised against the rabbit 59-kDa protein reacts with 9S , untransformed glucocorticoid receptor complexes in cytosol prepared from human IM-9 lymphocytes but not with 4S salt-transformed receptors . |
| In this work we show that the monoclonal antibody KN 382/EC1 raised against the rabbit 59-kDa protein reacts with protein9S , untransformed glucocorticoid receptor complexes in cytosol prepared from human IM-9 lymphocytes but not with 4S salt-transformed receptors . | |||
| In this work we show that the monoclonal antibody KN 382/EC1 raised against the rabbit 59-kDa protein reacts with 9S , proteinuntransformed glucocorticoid receptor complexes in cytosol prepared from human IM-9 lymphocytes but not with 4S salt-transformed receptors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2247 | 20.6121 | 1.0000 | The human protein recognized by the EC1 antibody is a protein56-kDa protein ( p56 ) of moderate abundance located predominantly in the cytoplasm by indirect immunofluorescence . |
| 1.4082 | 20.8719 | 1.0000 | The human protein recognized by the proteinEC1 antibody is a 56-kDa protein ( p56 ) of moderate abundance located predominantly in the cytoplasm by indirect immunofluorescence . |
| 0.9749 | 1.0000 | 1.0000 | The human protein recognized by the EC1 antibody is a 56-kDa protein ( proteinp56 ) of moderate abundance located predominantly in the cytoplasm by indirect immunofluorescence . |
| 1.3898 | 10.1159 | 0.9999 | The proteinhuman protein recognized by the EC1 antibody is a 56-kDa protein ( p56 ) of moderate abundance located predominantly in the cytoplasm by indirect immunofluorescence . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6753 | 10.9522 | 1.0000 | There are at least six isomorphs of proteinp56 by two-dimensional gel analysis . |
| There are at least six proteinisomorphs of p56 by two-dimensional gel analysis . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5639 | 20.7947 | 10.9858 | N-Terminal sequencing ( 20 amino acids ) shows that p56 is a proteinunique human protein . |
| 1.5262 | 10.8994 | 1.0000 | N-Terminal sequencing ( 20 amino acids ) shows that proteinp56 is a unique human protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1299 | 20.0392 | 0.9985 | When p56 is immunoadsorbed from cell_lineIM-9 cell cytosol , both the 70- and 90- kDa heat shock proteins are coadsorbed in an immune-specific manner . |
| 0.9306 | 0.9999 | 1.0000 | When proteinp56 is immunoadsorbed from IM-9 cell cytosol , both the 70- and 90- kDa heat shock proteins are coadsorbed in an immune-specific manner . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0941 | 10.8635 | 10.4087 | Neither proteinheat shock protein reacts directly with the EC1 antibody . |
| 2.0117 | 20.4533 | 0.9999 | Neither heat shock protein reacts directly with the proteinEC1 antibody . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5761 | 20.0431 | 1.0000 | We conclude that proteinp56 exists in cytosol in a higher order complex containing hsp70 and hsp90 , both of which in turn have been found to be associated with untransformed steroid receptors . |
| 1.8014 | 10.2439 | 1.0000 | We conclude that p56 exists in cytosol in a higher order complex containing proteinhsp70 and hsp90 , both of which in turn have been found to be associated with untransformed steroid receptors . |
| 0.9699 | 1.0000 | 1.0000 | We conclude that p56 exists in cytosol in a higher order complex containing hsp70 and proteinhsp90 , both of which in turn have been found to be associated with untransformed steroid receptors . |
| 2.3167 | 20.6125 | 0.9999 | We conclude that p56 exists in cytosol in a higher order complex containing hsp70 and hsp90 , both of which in turn have been found to be associated with untransformed proteinsteroid receptors . |
| We conclude that p56 exists in cytosol in a higher order complex containing hsp70 and hsp90 , both of which in turn have been found to be associated with proteinuntransformed steroid receptors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0756 | 20.6737 | 10.9446 | Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a DNAtranscriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus . |
| 3.5077 | 20.5840 | 10.6554 | Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the DNAlong terminal repeat of the Moloney murine sarcoma virus . |
| Sequence-specific DNA binding of the proto-oncoprotein proteinets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus . | |||
| Sequence-specific DNA binding of the proteinproto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9203 | 10.8364 | 10.8099 | The DNAets proto-oncogene family is a group of sequence-related genes whose normal cellular function is unknown. |
| 2.1341 | 20.2079 | 1.0000 | The ets proto-oncogene family is a group of DNAsequence-related genes whose normal cellular function is unknown. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7054 | 20.1622 | 10.7242 | In a study of cellular proteins involved in the transcriptional regulation of murine retroviruses in T lymphocytes , we have discovered that a member of the ets gene family encodes a proteinsequence-specific DNA-binding protein . |
| 3.6054 | 20.4963 | 10.7217 | In a study of cellular proteins involved in the transcriptional regulation of murine retroviruses in T lymphocytes , we have discovered that a member of the DNAets gene family encodes a sequence-specific DNA-binding protein . |
| 1.4892 | 10.9869 | 0.9999 | In a study of cellular proteins involved in the transcriptional regulation of murine retroviruses in cell_typeT lymphocytes , we have discovered that a member of the ets gene family encodes a sequence-specific DNA-binding protein . |
| 1.4743 | 10.9015 | 1.0000 | In a study of proteincellular proteins involved in the transcriptional regulation of murine retroviruses in T lymphocytes , we have discovered that a member of the ets gene family encodes a sequence-specific DNA-binding protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.5178 | 30.6721 | 20.2903 | A mouse ets-1 cDNA clone was obtained by screening a DNAmouse thymus cDNA expression library with a double-stranded oligonucleotide probe representing 20 bp of the Moloney murine sarcoma virus ( MSV ) long terminal repeat ( LTR ). |
| 1.4120 | 10.5313 | 0.9911 | A DNAmouse ets-1 cDNA clone was obtained by screening a mouse thymus cDNA expression library with a double-stranded oligonucleotide probe representing 20 bp of the Moloney murine sarcoma virus ( MSV ) long terminal repeat ( LTR ). |
| 0.9162 | 0.9998 | 0.9999 | A mouse ets-1 cDNA clone was obtained by screening a mouse thymus cDNA expression library with a double-stranded oligonucleotide probe representing 20 bp of the Moloney murine sarcoma virus ( MSV ) long terminal repeat ( DNALTR ). |
| 4.8513 | 20.8665 | 30.7236 | A mouse ets-1 cDNA clone was obtained by screening a mouse thymus cDNA expression library with a double-stranded oligonucleotide probe representing 20 bp of the DNAMoloney murine sarcoma virus ( MSV ) long terminal repeat ( LTR ). |
| A mouse ets-1 cDNA clone was obtained by screening a mouse thymus cDNA expression library with a DNAdouble-stranded oligonucleotide probe representing 20 bp of the Moloney murine sarcoma virus ( MSV ) long terminal repeat ( LTR ). | |||
| A mouse ets-1 cDNA clone was obtained by screening a mouse thymus cDNA expression library with a double-stranded oligonucleotide probe representing 20 bp of the Moloney murine sarcoma virus ( MSV ) DNAlong terminal repeat ( LTR ). | |||
| A mouse proteinets-1 cDNA clone was obtained by screening a mouse thymus cDNA expression library with a double-stranded oligonucleotide probe representing 20 bp of the Moloney murine sarcoma virus ( MSV ) long terminal repeat ( LTR ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1608 | 20.5327 | 10.6425 | The cDNA sequence has an 813-bp open reading frame ( ORF ) whose predicted amino acid sequence is 97.6% identical to the protein272 carboxy-terminal amino acids of the human ets-1 protein . |
| 3.9788 | 30.3770 | 10.6886 | The cDNA sequence has an 813-bp open reading frame ( ORF ) whose predicted amino acid sequence is 97.6% identical to the 272 carboxy-terminal amino acids of the proteinhuman ets-1 protein . |
| 3.9670 | 20.3683 | 10.9492 | The cDNA sequence has an 813-bp open reading frame ( ORF ) whose predicted proteinamino acid sequence is 97.6% identical to the 272 carboxy-terminal amino acids of the human ets-1 protein . |
| 3.8706 | 20.6326 | 10.8244 | The cDNA sequence has an DNA813-bp open reading frame ( ORF ) whose predicted amino acid sequence is 97.6% identical to the 272 carboxy-terminal amino acids of the human ets-1 protein . |
| 1.3217 | 10.9057 | 0.9998 | The DNAcDNA sequence has an 813-bp open reading frame ( ORF ) whose predicted amino acid sequence is 97.6% identical to the 272 carboxy-terminal amino acids of the human ets-1 protein . |
| 0.9408 | 1.0000 | 1.0000 | The cDNA sequence has an 813-bp open reading frame ( DNAORF ) whose predicted amino acid sequence is 97.6% identical to the 272 carboxy-terminal amino acids of the human ets-1 protein . |
| The cDNA sequence has an 813-bp open reading frame ( ORF ) whose predicted amino acid sequence is 97.6% identical to the 272 carboxy-terminal amino acids of the human proteinets-1 protein . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1041 | 20.8185 | 10.6667 | The ORF was expressed in bacteria , and the protein30-kD protein product was shown to bind DNA in a sequence-specific manner by mobility-shift assays , Southwestern blot analysis , and methylation interference . |
| 0.9307 | 0.9999 | 1.0000 | The DNAORF was expressed in bacteria , and the 30-kD protein product was shown to bind DNA in a sequence-specific manner by mobility-shift assays , Southwestern blot analysis , and methylation interference . |
| 0.7020 | 1.0000 | 1.0000 | The ORF was expressed in bacteria , and the 30-kD protein product was shown to bind DNADNA in a sequence-specific manner by mobility-shift assays , Southwestern blot analysis , and methylation interference . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7785 | 20.3220 | 10.6303 | A mutant LTR containing four base pair substitutions in the DNAets-1 binding site was constructed and was shown to have reduced binding in vitro. |
| 1.6350 | 10.6093 | 0.9999 | A DNAmutant LTR containing four base pair substitutions in the ets-1 binding site was constructed and was shown to have reduced binding in vitro. |
| A mutant LTR containing four base pair substitutions in the proteinets-1 binding site was constructed and was shown to have reduced binding in vitro. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7277 | 20.2342 | 10.8809 | Transcriptional efficiency of the MSV LTR promoter containing this disrupted DNAets-1 binding site was compared to the activity of a wild-type promoter in mouse T lymphocytes in culture, and 15- to 20-fold reduction in expression of a reporter gene was observed. |
| 3.6862 | 20.6537 | 10.7437 | Transcriptional efficiency of the DNAMSV LTR promoter containing this disrupted ets-1 binding site was compared to the activity of a wild-type promoter in mouse T lymphocytes in culture, and 15- to 20-fold reduction in expression of a reporter gene was observed. |
| 3.0657 | 10.7012 | 10.8551 | Transcriptional efficiency of the MSV LTR promoter containing this disrupted ets-1 binding site was compared to the activity of a wild-type promoter in cell_typemouse T lymphocytes in culture, and 15- to 20-fold reduction in expression of a reporter gene was observed. |
| 2.0425 | 20.6660 | 0.9997 | Transcriptional efficiency of the MSV LTR promoter containing this disrupted ets-1 binding site was compared to the activity of a wild-type promoter in mouse T lymphocytes in culture, and 15- to 20-fold reduction in expression of a DNAreporter gene was observed. |
| 1.4298 | 10.8680 | 0.9998 | Transcriptional efficiency of the MSV LTR promoter containing this disrupted ets-1 binding site was compared to the activity of a DNAwild-type promoter in mouse T lymphocytes in culture, and 15- to 20-fold reduction in expression of a reporter gene was observed. |
| Transcriptional efficiency of the MSV LTR promoter containing this disrupted ets-1 binding site was compared to the activity of a wild-type promoter in mouse cell_typeT lymphocytes in culture, and 15- to 20-fold reduction in expression of a reporter gene was observed. | |||
| Transcriptional efficiency of the MSV LTR promoter containing this disrupted proteinets-1 binding site was compared to the activity of a wild-type promoter in mouse T lymphocytes in culture, and 15- to 20-fold reduction in expression of a reporter gene was observed. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6878 | 20.8758 | 10.7572 | We propose that ets-1 functions as a transcriptional activator of mammalian type-C retroviruses and speculate that ets-related genes constitute a new group of proteineukaryotic DNA-binding proteins . |
| 2.2001 | 20.1780 | 1.0000 | We propose that ets-1 functions as a transcriptional activator of mammalian type-C retroviruses and speculate that DNAets-related genes constitute a new group of eukaryotic DNA-binding proteins . |
| 2.2885 | 20.0001 | 1.0000 | We propose that DNAets-1 functions as a transcriptional activator of mammalian type-C retroviruses and speculate that ets-related genes constitute a new group of eukaryotic DNA-binding proteins . |
| We propose that proteinets-1 functions as a transcriptional activator of mammalian type-C retroviruses and speculate that ets-related genes constitute a new group of eukaryotic DNA-binding proteins . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9894 | 10.7548 | 20.4204 | Type II estrogen binding sites in cell_typehuman peripheral blood mononuclear cells : variations during the menstrual cycle . |
| 2.3190 | 0.9981 | 20.6010 | proteinType II estrogen binding sites in human peripheral blood mononuclear cells : variations during the menstrual cycle . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.8909 | 30.2239 | 20.0915 | We have previously reported that cell_typehuman peripheral blood mononuclear cells ( PBMC ) contain type II estrogen binding sites ( type II EBS ). |
| 2.0591 | 10.6847 | 10.0973 | We have previously reported that human peripheral blood mononuclear cells ( PBMC ) contain type II estrogen binding sites ( proteintype II EBS ). |
| 0.8891 | 0.9999 | 0.9999 | We have previously reported that human peripheral blood mononuclear cells ( cell_typePBMC ) contain type II estrogen binding sites ( type II EBS ). |
| 3.6388 | 20.7256 | 10.8212 | We have previously reported that human peripheral blood mononuclear cells ( PBMC ) contain proteintype II estrogen binding sites ( type II EBS ). |
| We have previously reported that human peripheral blood mononuclear cells ( PBMC ) contain type proteinII estrogen binding sites ( type II EBS ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1932 | 20.8483 | 10.4213 | In this study, the fluctuations of proteintype II EBS during the menstrual cycle were analyzed in 6 normally menstruating women . |
| 0.6246 | 1.0000 | 1.0000 | In this study, the fluctuations of type II proteinEBS during the menstrual cycle were analyzed in 6 normally menstruating women . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1033 | 20.9672 | 10.8137 | Approximately 3 times higher levels of proteintype II EBS were found in the periovulatory period with respect to both follicular and luteal phases . |
| 0.9282 | 1.0000 | 1.0000 | Approximately 3 times higher levels of type II proteinEBS were found in the periovulatory period with respect to both follicular and luteal phases . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8049 | 20.7906 | 10.7255 | In postmenopausal women the mean proteintype II EBS levels were similar to those observed in the follicular phase of the cycle. |
| 0.7391 | 1.0000 | 1.0000 | In postmenopausal women the mean type II proteinEBS levels were similar to those observed in the follicular phase of the cycle. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6449 | 20.6631 | 10.8862 | However, in 3 postmenopausal patients a short course of estrogen or tamoxifen resulted in a marked increase of proteintype II EBS levels. |
| 0.9737 | 1.0000 | 1.0000 | However, in 3 postmenopausal patients a short course of estrogen or tamoxifen resulted in a marked increase of type II proteinEBS levels. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0512 | 20.4523 | 10.8977 | Tamoxifen was also found to compete with 17 beta-estradiol for proteintype II EBS in PBMC , although to a lesser extent than diethylstilbestrol . |
| 0.9456 | 0.9999 | 1.0000 | Tamoxifen was also found to compete with 17 beta-estradiol for type II EBS in cell_typePBMC , although to a lesser extent than diethylstilbestrol . |
| 0.9581 | 1.0000 | 1.0000 | Tamoxifen was also found to compete with 17 beta-estradiol for type II proteinEBS in PBMC , although to a lesser extent than diethylstilbestrol . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8962 | 0.9926 | 0.9999 | Mononuclear leukocyte proteinglucocorticoid receptor binding characteristics and down-regulation in major depression . |
| 0.8263 | 0.9989 | 0.9878 | cell_typeMononuclear leukocyte glucocorticoid receptor binding characteristics and down-regulation in major depression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6993 | 10.9306 | 1.0000 | To study whether this represents glucocorticoid ( GC ) resistance , [3H]-DEX-binding assays were used to measure, in vitro, the GC receptor affinity (1/Kd) and number ( Bmax ) in cell_typemononuclear leukocytes of 11 MDD patients and 15 control subjects . |
| 1.6945 | 10.9924 | 1.0000 | To study whether this represents glucocorticoid ( GC ) resistance , [3H]-DEX-binding assays were used to measure, in vitro, the proteinGC receptor affinity (1/Kd) and number ( Bmax ) in mononuclear leukocytes of 11 MDD patients and 15 control subjects . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3889 | 20.1513 | 0.9999 | DEX (1.0 mg orally) was administered to study in vivo proteinGC receptor down-regulation . |
| DEX (1.0 mg orally) was administered to study in proteinvivo GC receptor down-regulation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8272 | 10.1888 | 1.0000 | Receptor number on the control day did not correlate significantly with the degree of proteinreceptor down-regulation , severity of depression or cortisol concentrations across all the subjects. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5406 | 0.9983 | 10.6161 | proteinRas-related GTP-binding proteins and leukocyte signal transduction . |
| Ras-related GTP-binding proteins and cell_typeleukocyte signal transduction . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2651 | 10.9917 | 10.9762 | Many aspects of leukocyte function are regulated by both heterotrimeric and proteinRas-related GTP-binding proteins , but there is little definite information about their roles in the specialized processes utilized by leukocytes for cell killing. |
| 1.7246 | 10.3372 | 1.0000 | Many aspects of leukocyte function are regulated by both heterotrimeric and Ras-related GTP-binding proteins , but there is little definite information about their roles in the specialized processes utilized by cell_typeleukocytes for cell killing. |
| 0.8517 | 0.9995 | 1.0000 | Many aspects of leukocyte function are regulated by both proteinheterotrimeric and Ras-related GTP-binding proteins , but there is little definite information about their roles in the specialized processes utilized by leukocytes for cell killing. |
| 0.8237 | 1.0000 | 0.9999 | Many aspects of cell_typeleukocyte function are regulated by both heterotrimeric and Ras-related GTP-binding proteins , but there is little definite information about their roles in the specialized processes utilized by leukocytes for cell killing. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7422 | 20.4847 | 10.9898 | Recent progress in understanding the regulation of the proteinphagocyte NADPH oxidase by the Rac GTP-binding proteins provides a basis for defining the operational characteristics of one such phagocyte system . |
| 2.9969 | 20.1898 | 10.6271 | Recent progress in understanding the regulation of the phagocyte NADPH oxidase by the proteinRac GTP-binding proteins provides a basis for defining the operational characteristics of one such phagocyte system . |
| 1.3042 | 10.6559 | 0.9965 | Recent progress in understanding the regulation of the phagocyte NADPH oxidase by the proteinRac GTP-binding proteins provides a basis for defining the operational characteristics of one such phagocyte system . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2823 | 20.6550 | 1.0000 | It is clear from various studies that the activity of the proteinNADPH oxidase can be modulated through the regulation of the GTP-GDP state of Rac . |
| 2.2264 | 20.9231 | 0.9999 | It is clear from various studies that the activity of the NADPH oxidase can be modulated through the regulation of the proteinGTP-GDP state of Rac . |
| 1.6444 | 10.1025 | 1.0000 | It is clear from various studies that the activity of the NADPH oxidase can be modulated through the regulation of the GTP-GDP state of proteinRac . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4602 | 20.2688 | 1.0000 | Proteins exist in leukocytes able to modify proteinGTP-binding protein function in this manner, and their activity may be regulated by signals generated on phagocyte stimulation . |
| 0.8848 | 0.9999 | 1.0000 | Proteins exist in cell_typeleukocytes able to modify GTP-binding protein function in this manner, and their activity may be regulated by signals generated on phagocyte stimulation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4546 | 20.0754 | 1.0000 | Proteins of the proteinRas superfamily are likely to be involved in a variety of normal phagocyte functions through their ability to modulate the assembly of actin filaments , direct vesicle trafficking and fusion, and so forth. |
| 2.3843 | 20.3345 | 1.0000 | Proteins of the Ras superfamily are likely to be involved in a variety of normal phagocyte functions through their ability to modulate the assembly of proteinactin filaments , direct vesicle trafficking and fusion, and so forth. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9754 | 1.0000 | 1.0000 | proteinBSAP : a key regulator of B-cell development and differentiation . |
| BSAP : a key regulator of cell_typeB-cell development and differentiation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6797 | 10.5288 | 1.0000 | B-cell-specific activator protein ( BSAP ) is a recently identified member of the Pax-gene family of transcription factors ; in the lymphoid system , proteinBSAP is produced only in B cells . |
| 1.5274 | 10.4374 | 0.9999 | B-cell-specific activator protein ( BSAP ) is a recently identified member of the Pax-gene family of proteintranscription factors ; in the lymphoid system , BSAP is produced only in B cells . |
| 1.4367 | 20.5050 | 0.9997 | B-cell-specific activator protein ( BSAP ) is a recently identified member of the Pax-gene family of transcription factors ; in the lymphoid system , BSAP is produced only in cell_typeB cells . |
| 0.9696 | 1.0000 | 1.0000 | B-cell-specific activator protein ( proteinBSAP ) is a recently identified member of the Pax-gene family of transcription factors ; in the lymphoid system , BSAP is produced only in B cells . |
| 0.7952 | 0.9954 | 0.9993 | proteinB-cell-specific activator protein ( BSAP ) is a recently identified member of the Pax-gene family of transcription factors ; in the lymphoid system , BSAP is produced only in B cells . |
| 2.2054 | 20.9152 | 0.9999 | B-cell-specific activator protein ( BSAP ) is a recently identified member of the proteinPax-gene family of transcription factors ; in the lymphoid system , BSAP is produced only in B cells . |
| B-cell-specific activator protein ( BSAP ) is a recently identified member of the DNAPax-gene family of transcription factors ; in the lymphoid system , BSAP is produced only in B cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3138 | 20.8618 | 0.9999 | Here, Markus Neurath, Eckhard Stuber and Warren Strober describe the molecular structure of BSAP and focus on the ability of this protein to regulate the expression of DNAB-cell-specific genes . |
| 1.7177 | 10.5129 | 1.0000 | Here, Markus Neurath, Eckhard Stuber and Warren Strober describe the molecular structure of proteinBSAP and focus on the ability of this protein to regulate the expression of B-cell-specific genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7576 | 10.5260 | 1.0000 | They propose that proteinBSAP is a key protein of B cells and that it not only influence B-cell development but also influences the balance between B-cell proliferation and immunoglobulin secretion at later stages of B-cell differentiation . |
| 1.7300 | 10.9993 | 1.0000 | They propose that BSAP is a key protein of B cells and that it not only influence B-cell development but also influences the balance between B-cell proliferation and proteinimmunoglobulin secretion at later stages of B-cell differentiation . |
| 1.6711 | 10.9030 | 1.0000 | They propose that BSAP is a key protein of cell_typeB cells and that it not only influence B-cell development but also influences the balance between B-cell proliferation and immunoglobulin secretion at later stages of B-cell differentiation . |
| 0.5821 | 1.0000 | 0.9999 | They propose that BSAP is a key protein of B cells and that it not only influence B-cell development but also influences the balance between cell_typeB-cell proliferation and immunoglobulin secretion at later stages of B-cell differentiation . |
| 0.5788 | 1.0000 | 0.9999 | They propose that BSAP is a key protein of B cells and that it not only influence B-cell development but also influences the balance between B-cell proliferation and immunoglobulin secretion at later stages of cell_typeB-cell differentiation . |
| They propose that BSAP is a proteinkey protein of B cells and that it not only influence B-cell development but also influences the balance between B-cell proliferation and immunoglobulin secretion at later stages of B-cell differentiation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8001 | 20.3268 | 10.9976 | Down-regulation of NF-kappa B protein levels in cell_typeactivated human lymphocytes by 1,25-dihydroxyvitamin D3 [published erratum appears in Proc Natl Acad Sci U S A 1996 Jan 9;93(1):524] |
| 2.3314 | 20.6535 | 0.9999 | Down-regulation of proteinNF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3 [published erratum appears in Proc Natl Acad Sci U S A 1996 Jan 9;93(1):524] |
| Down-regulation of proteinNF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3 [published erratum appears in Proc Natl Acad Sci U S A 1996 Jan 9;93(1):524] | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1646 | 30.4033 | 10.5591 | The effect of 1,25-dihydroxyvitamin D3 [ 1,25(OH)2)D3 ], a steroid hormone with immunomodulating properties, on proteinnuclear factor kappa B ( NF-kappa B ) proteins was examined in in vitro activated normal human lymphocytes by Western blot analysis . |
| 0.9215 | 1.0000 | 0.9645 | The effect of 1,25-dihydroxyvitamin D3 [ 1,25(OH)2)D3 ], a steroid hormone with immunomodulating properties, on nuclear factor kappa B ( proteinNF-kappa B ) proteins was examined in in vitro activated normal human lymphocytes by Western blot analysis . |
| 7.8448 | 40.4567 | 20.8695 | The effect of 1,25-dihydroxyvitamin D3 [ 1,25(OH)2)D3 ], a steroid hormone with immunomodulating properties, on nuclear factor kappa B ( NF-kappa B ) proteins was examined in cell_typein vitro activated normal human lymphocytes by Western blot analysis . |
| 4.7446 | 30.8268 | 20.7641 | The effect of 1,25-dihydroxyvitamin D3 [ 1,25(OH)2)D3 ], a steroid hormone with immunomodulating properties, on proteinnuclear factor kappa B ( NF-kappa B ) proteins was examined in in vitro activated normal human lymphocytes by Western blot analysis . |
| The effect of 1,25-dihydroxyvitamin D3 [ 1,25(OH)2)D3 ], a steroid hormone with immunomodulating properties, on nuclear factor kappa B ( NF-kappa B ) proteins was examined in cell_linein vitro activated normal human lymphocytes by Western blot analysis . | |||
| The effect of 1,25-dihydroxyvitamin D3 [ 1,25(OH)2)D3 ], a steroid hormone with immunomodulating properties, on nuclear factor kappa B ( NF-kappa B ) proteins was examined in in vitro activated normal cell_typehuman lymphocytes by Western blot analysis . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5875 | 20.5709 | 10.7936 | Over a 72-hr period of activation, the expression of the protein50-kDa NF-kappa B , p50 , and its precursor, p105 , was increased progressively. |
| 1.6580 | 10.2298 | 1.0000 | Over a 72-hr period of activation, the expression of the 50-kDa NF-kappa B , p50 , and its precursor, proteinp105 , was increased progressively. |
| 0.9561 | 1.0000 | 1.0000 | Over a 72-hr period of activation, the expression of the 50-kDa NF-kappa B , proteinp50 , and its precursor, p105 , was increased progressively. |
| 0.7328 | 0.9999 | 0.9999 | Over a 72-hr period of activation, the expression of the 50-kDa proteinNF-kappa B , p50 , and its precursor, p105 , was increased progressively. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5218 | 20.2963 | 1.0000 | When cells were activated in the presence of 1,25(OH)2D3 , the levels of the proteinmature protein as well as its precursor were decreased. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8074 | 10.3989 | 1.0000 | The effect of the hormone on the levels of proteinp50 was demonstrable in the cytosolic and nuclear compartments ; it required between 4 and 8 hr and was specific, as 25-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 were ineffective. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3152 | 20.2940 | 0.9999 | Besides p50 , 1,25(OH)2D3 decreased the levels of another proteinNF-kappa B protein , namely c-rel . |
| 1.5307 | 10.4238 | 1.0000 | Besides proteinp50 , 1,25(OH)2D3 decreased the levels of another NF-kappa B protein , namely c-rel . |
| 1.4021 | 10.6975 | 1.0000 | Besides p50 , 1,25(OH)2D3 decreased the levels of another NF-kappa B protein , namely proteinc-rel . |
| 1.7053 | 20.4423 | 0.8704 | Besides p50 , 1,25(OH)2D3 decreased the levels of another proteinNF-kappa B protein , namely c-rel . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9366 | 20.4009 | 0.9849 | In addition, 1,25(OH)2D3 decreased the abundance of a specific DNA-protein complex formed upon incubation of nuclear extracts from activated lymphocytes with a labeled proteinNF-kappa B DNA binding motif . |
| 4.9814 | 20.7598 | 10.6323 | In addition, 1,25(OH)2D3 decreased the abundance of a specific DNA-protein complex formed upon incubation of nuclear extracts from activated lymphocytes with a labeled DNANF-kappa B DNA binding motif . |
| 1.4127 | 10.9640 | 0.9999 | In addition, 1,25(OH)2D3 decreased the abundance of a specific proteinDNA-protein complex formed upon incubation of nuclear extracts from activated lymphocytes with a labeled NF-kappa B DNA binding motif . |
| 1.3750 | 10.7701 | 0.9997 | In addition, 1,25(OH)2D3 decreased the abundance of a specific DNA-protein complex formed upon incubation of nuclear extracts from cell_typeactivated lymphocytes with a labeled NF-kappa B DNA binding motif . |
| 0.7054 | 1.0000 | 0.9999 | In addition, 1,25(OH)2D3 decreased the abundance of a specific DNA-protein complex formed upon incubation of nuclear extracts from activated cell_typelymphocytes with a labeled NF-kappa B DNA binding motif . |
| In addition, 1,25(OH)2D3 decreased the abundance of a specific DNA-protein complex formed upon incubation of nuclear extracts from activated lymphocytes with a labeled proteinNF-kappa B DNA binding motif . | |||
| In addition, 1,25(OH)2D3 decreased the abundance of a proteinspecific DNA-protein complex formed upon incubation of nuclear extracts from activated lymphocytes with a labeled NF-kappa B DNA binding motif . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.2594 | 30.6000 | 10.7972 | Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a construct containing four tandem repeats of the NF-kappa B binding sequence of the DNAimmunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase reporter gene . |
| 3.8255 | 20.7849 | 10.8755 | Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a construct containing four tandem repeats of the DNANF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase reporter gene . |
| 2.9151 | 20.9866 | 10.4070 | Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a construct containing four tandem repeats of the NF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the DNAchloramphenicol acetyltransferase reporter gene . |
| 2.1720 | 30.6153 | 0.9800 | Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a construct containing four tandem repeats of the NF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the proteinchloramphenicol acetyltransferase reporter gene . |
| 2.0832 | 20.3331 | 1.0000 | Further, 1,25(OH)2D3 inhibited the transcriptional activity of proteinNF-kappa B in Jurkat cells transiently transfected with a construct containing four tandem repeats of the NF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase reporter gene . |
| 1.8777 | 20.8271 | 0.9631 | Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a construct containing four tandem repeats of the proteinNF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase reporter gene . |
| 1.4791 | 10.8928 | 0.9999 | Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in cell_lineJurkat cells transiently transfected with a construct containing four tandem repeats of the NF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase reporter gene . |
| 1.1557 | 0.9992 | 10.2052 | Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a construct containing four tandem repeats of the NF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase DNAreporter gene . |
| Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a construct containing four DNAtandem repeats of the NF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase reporter gene . | |||
| Further, 1,25(OH)2D3 inhibited the transcriptional activity of NF-kappa B in Jurkat cells transiently transfected with a DNAconstruct containing four tandem repeats of the NF-kappa B binding sequence of the immunoglobulin kappa light chain gene linked to the chloramphenicol acetyltransferase reporter gene . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5431 | 10.7061 | 1.0000 | These observations demonstrate directly that there is de novo synthesis of proteinNF-kappa B during human lymphocyte activation and suggest that this process is hormonally regulated. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0067 | 10.9118 | 10.2286 | The DNAmyeloid zinc finger gene , MZF-1 , regulates the CD34 promoter in vitro. |
| 1.9730 | 20.9693 | 1.0000 | The myeloid zinc finger gene , MZF-1 , regulates the DNACD34 promoter in vitro. |
| 0.9268 | 1.0000 | 1.0000 | The myeloid zinc finger gene , DNAMZF-1 , regulates the CD34 promoter in vitro. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8590 | 30.3269 | 10.7508 | MZF-1 is a C2H2 zinc finger gene encoding a proteinputative transcriptional regulator of myeloid differentiation . |
| 3.6745 | 20.7879 | 10.6618 | MZF-1 is a DNAC2H2 zinc finger gene encoding a putative transcriptional regulator of myeloid differentiation . |
| 0.9361 | 0.9999 | 1.0000 | DNAMZF-1 is a C2H2 zinc finger gene encoding a putative transcriptional regulator of myeloid differentiation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6504 | 10.7951 | 10.6653 | The MZF-1 protein contains 13 proteinC2H2 zinc fingers arranged in bipartite DNA binding domains containing zinc fingers through 4 and, in the carboxy-terminus , 5 through 13. |
| 0.8076 | 1.0000 | 1.0000 | The MZF-1 protein contains 13 C2H2 zinc fingers arranged in bipartite DNA binding domains containing zinc fingers through 4 and, in the proteincarboxy-terminus , 5 through 13. |
| 0.7573 | 0.9988 | 0.9999 | The MZF-1 protein contains 13 C2H2 zinc fingers arranged in bipartite DNA binding domains containing proteinzinc fingers through 4 and, in the carboxy-terminus , 5 through 13. |
| 4.3679 | 20.3177 | 10.7092 | The MZF-1 protein contains 13 C2H2 zinc fingers arranged in proteinbipartite DNA binding domains containing zinc fingers through 4 and, in the carboxy-terminus , 5 through 13. |
| 1.3869 | 10.6411 | 1.0000 | The proteinMZF-1 protein contains 13 C2H2 zinc fingers arranged in bipartite DNA binding domains containing zinc fingers through 4 and, in the carboxy-terminus , 5 through 13. |
| 1.3184 | 10.7916 | 0.9926 | The proteinMZF-1 protein contains 13 C2H2 zinc fingers arranged in bipartite DNA binding domains containing zinc fingers through 4 and, in the carboxy-terminus , 5 through 13. |
| The MZF-1 protein contains 13 C2H2 zinc fingers arranged in bipartite proteinDNA binding domains containing zinc fingers through 4 and, in the carboxy-terminus , 5 through 13. | |||
| The DNAMZF-1 protein contains 13 C2H2 zinc fingers arranged in bipartite DNA binding domains containing zinc fingers through 4 and, in the carboxy-terminus , 5 through 13. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7560 | 20.9354 | 10.4363 | We previously identified the DNADNA consensus binding site recognized by the two DNA binding domains . |
| 3.7122 | 20.8799 | 10.7925 | We previously identified the DNA consensus binding site recognized by the two proteinDNA binding domains . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.7963 | 20.9972 | 10.7395 | To assess the transcription regulatory function of MZF-1 , the full-length MZF-1 coding region was fused to the proteinDNA binding domain of the yeast transactivator GAL4 . |
| 0.9476 | 1.0000 | 1.0000 | To assess the transcription regulatory function of MZF-1 , the full-length MZF-1 coding region was fused to the DNA binding domain of the yeast transactivator proteinGAL4 . |
| 2.9358 | 20.7049 | 10.8481 | To assess the transcription regulatory function of MZF-1 , the full-length DNAMZF-1 coding region was fused to the DNA binding domain of the yeast transactivator GAL4 . |
| 1.8782 | 20.4769 | 0.9992 | To assess the transcription regulatory function of MZF-1 , the full-length MZF-1 coding region was fused to the DNA binding domain of the proteinyeast transactivator GAL4 . |
| 1.4155 | 10.7249 | 0.9972 | To assess the transcription regulatory function of MZF-1 , the full-length proteinMZF-1 coding region was fused to the DNA binding domain of the yeast transactivator GAL4 . |
| 1.3735 | 10.7473 | 1.0000 | To assess the transcription regulatory function of proteinMZF-1 , the full-length MZF-1 coding region was fused to the DNA binding domain of the yeast transactivator GAL4 . |
| To assess the transcription regulatory function of DNAMZF-1 , the full-length MZF-1 coding region was fused to the DNA binding domain of the yeast transactivator GAL4 . | |||
| To assess the transcription regulatory function of MZF-1 , the full-length DNAMZF-1 coding region was fused to the DNA binding domain of the yeast transactivator GAL4 . | |||
| To assess the transcription regulatory function of MZF-1 , the full-length MZF-1 coding region was fused to the DNA binding domain of the proteinyeast transactivator GAL4 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7805 | 20.9331 | 10.6415 | The expression vector was cotransfected with the DNAchloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing GAL4 DNA binding sites into NIH 3T3 , 293 , K562 , and Jurkat cell lines . |
| 3.6270 | 30.2155 | 10.9630 | The expression vector was cotransfected with the proteinchloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing GAL4 DNA binding sites into NIH 3T3 , 293 , K562 , and Jurkat cell lines . |
| 3.5792 | 20.4165 | 10.9588 | The expression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the DNAthymidine kinase promoter containing GAL4 DNA binding sites into NIH 3T3 , 293 , K562 , and Jurkat cell lines . |
| 3.3919 | 20.5982 | 10.5810 | The expression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing GAL4 DNA binding sites into NIH 3T3 , 293 , K562 , and cell_lineJurkat cell lines . |
| 2.9682 | 10.7007 | 10.7776 | The expression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing DNAGAL4 DNA binding sites into NIH 3T3 , 293 , K562 , and Jurkat cell lines . |
| 0.9035 | 1.0000 | 1.0000 | The expression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing GAL4 DNA binding sites into NIH 3T3 , cell_line293 , K562 , and Jurkat cell lines . |
| 0.8832 | 1.0000 | 1.0000 | The expression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing GAL4 DNA binding sites into NIH 3T3 , 293 , cell_lineK562 , and Jurkat cell lines . |
| 0.7738 | 0.9993 | 0.9999 | The expression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing GAL4 DNA binding sites into cell_lineNIH 3T3 , 293 , K562 , and Jurkat cell lines . |
| 1.2938 | 10.6313 | 0.9998 | The DNAexpression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing GAL4 DNA binding sites into NIH 3T3 , 293 , K562 , and Jurkat cell lines . |
| The expression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the thymidine kinase promoter containing proteinGAL4 DNA binding sites into NIH 3T3 , 293 , K562 , and Jurkat cell lines . | |||
| The expression vector was cotransfected with the chloramphenicol acetyl transferase (CAT) reporter gene regulated by the proteinthymidine kinase promoter containing GAL4 DNA binding sites into NIH 3T3 , 293 , K562 , and Jurkat cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9263 | 20.4604 | 10.9779 | MZF-1 represses CAT reporter gene expression via GAL4 binding sites in the cell_linenonhematopoietic cell lines NIH 3T3 and 293 . |
| 2.6465 | 10.4126 | 10.3640 | MZF-1 represses DNACAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293 . |
| 0.9130 | 1.0000 | 0.9999 | MZF-1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and cell_line293 . |
| 0.8228 | 0.9976 | 0.9994 | MZF-1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines cell_lineNIH 3T3 and 293 . |
| 2.5232 | 10.9109 | 10.8327 | MZF-1 represses CAT reporter gene expression via DNAGAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293 . |
| 0.9500 | 1.0000 | 1.0000 | proteinMZF-1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293 . |
| 0.6313 | 1.0000 | 0.9999 | MZF-1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH cell_line3T3 and 293 . |
| MZF-1 represses CAT reporter gene expression via proteinGAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293 . | |||
| DNAMZF-1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3893 | 20.3329 | 10.7414 | In contrast, MZF-1 activates DNACAT reporter gene expression in the hematopoietic cell lines K562 and Jurkat . |
| 3.3545 | 20.1895 | 10.6465 | In contrast, MZF-1 activates CAT reporter gene expression in the cell_linehematopoietic cell lines K562 and Jurkat . |
| 0.9117 | 0.9999 | 0.9998 | In contrast, MZF-1 activates CAT reporter gene expression in the hematopoietic cell lines cell_lineK562 and Jurkat . |
| 0.9049 | 1.0000 | 1.0000 | In contrast, MZF-1 activates CAT reporter gene expression in the hematopoietic cell lines K562 and cell_lineJurkat . |
| 1.6729 | 10.0743 | 1.0000 | In contrast, proteinMZF-1 activates CAT reporter gene expression in the hematopoietic cell lines K562 and Jurkat . |
| In contrast, DNAMZF-1 activates CAT reporter gene expression in the hematopoietic cell lines K562 and Jurkat . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0202 | 10.7998 | 10.9423 | The DNAMZF-1 binding sites are present in the promoters of several genes expressed during myeloid differentiation , including the CD34 promoter . |
| 2.0721 | 20.8282 | 0.9999 | The MZF-1 binding sites are present in the promoters of several genes expressed during myeloid differentiation , including the DNACD34 promoter . |
| 0.8956 | 1.0000 | 1.0000 | The MZF-1 binding sites are present in the DNApromoters of several genes expressed during myeloid differentiation , including the CD34 promoter . |
| 1.7931 | 20.7774 | 0.9782 | The MZF-1 binding sites are present in the promoters of several genes expressed during myeloid differentiation , including the proteinCD34 promoter . |
| 0.7735 | 0.9999 | 0.9954 | The proteinMZF-1 binding sites are present in the promoters of several genes expressed during myeloid differentiation , including the CD34 promoter . |
| The MZF-1 binding sites are present in the promoters of several DNAgenes expressed during myeloid differentiation , including the CD34 promoter . | |||
| The DNAMZF-1 binding sites are present in the promoters of several genes expressed during myeloid differentiation , including the CD34 promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9874 | 1.0000 | 1.0000 | proteinMZF-1 transcriptional regulation of this physiologically relevant promoter was assessed in both hematopoietic and nonhematopoietic cell lines . |
| MZF-1 transcriptional regulation of this physiologically relevant promoter was assessed in both hematopoietic and cell_linenonhematopoietic cell lines . | |||
| MZF-1 transcriptional regulation of this DNAphysiologically relevant promoter was assessed in both hematopoietic and nonhematopoietic cell lines . | |||
| DNAMZF-1 transcriptional regulation of this physiologically relevant promoter was assessed in both hematopoietic and nonhematopoietic cell lines . | |||
| MZF-1 transcriptional regulation of this physiologically relevant promoter was assessed in both cell_linehematopoietic and nonhematopoietic cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5162 | 20.4291 | 10.4423 | Recombinant MZF-1 protein specifically binds to the DNAconsensus binding sites in the CD34 promoter in mobility shift assays . |
| 2.1072 | 20.3030 | 1.0000 | Recombinant MZF-1 protein specifically binds to the consensus binding sites in the DNACD34 promoter in mobility shift assays . |
| 1.7965 | 20.4296 | 0.9871 | Recombinant MZF-1 protein specifically binds to the consensus binding sites in the proteinCD34 promoter in mobility shift assays . |
| 0.8972 | 0.9999 | 0.9975 | Recombinant proteinMZF-1 protein specifically binds to the consensus binding sites in the CD34 promoter in mobility shift assays . |
| 0.5160 | 0.9920 | 1.0000 | Recombinant proteinMZF-1 protein specifically binds to the consensus binding sites in the CD34 promoter in mobility shift assays . |
| proteinRecombinant MZF-1 protein specifically binds to the consensus binding sites in the CD34 promoter in mobility shift assays . | |||
| Recombinant DNAMZF-1 protein specifically binds to the consensus binding sites in the CD34 promoter in mobility shift assays . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5668 | 20.4770 | 10.8679 | MZF-1 expression vectors were cotransfected with the DNAluciferase reporter plasmids regulated by the CD34 promoter into both nonhematopoietic and hematopoietic cell lines . |
| 1.3332 | 10.9751 | 0.9999 | MZF-1 expression vectors were cotransfected with the luciferase reporter plasmids regulated by the DNACD34 promoter into both nonhematopoietic and hematopoietic cell lines . |
| 2.5640 | 10.6851 | 10.3048 | MZF-1 expression vectors were cotransfected with the luciferase reporter plasmids regulated by the CD34 promoter into both nonhematopoietic and cell_linehematopoietic cell lines . |
| 1.4611 | 0.9926 | 10.6429 | DNAMZF-1 expression vectors were cotransfected with the luciferase reporter plasmids regulated by the CD34 promoter into both nonhematopoietic and hematopoietic cell lines . |
| 0.8587 | 1.0000 | 0.9927 | proteinMZF-1 expression vectors were cotransfected with the luciferase reporter plasmids regulated by the CD34 promoter into both nonhematopoietic and hematopoietic cell lines . |
| DNAMZF-1 expression vectors were cotransfected with the luciferase reporter plasmids regulated by the CD34 promoter into both nonhematopoietic and hematopoietic cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4063 | 20.6282 | 10.6195 | As with the heterologous DNA binding domain , MZF-1 represses reporter gene expression in cell_linenonhematopoietic cell lines and activates expression in hematopoietic cell lines . |
| 3.3087 | 20.9135 | 10.5486 | As with the heterologous DNA binding domain , MZF-1 represses reporter gene expression in nonhematopoietic cell lines and activates expression in cell_linehematopoietic cell lines . |
| 3.5835 | 20.9226 | 10.6945 | As with the proteinheterologous DNA binding domain , MZF-1 represses reporter gene expression in nonhematopoietic cell lines and activates expression in hematopoietic cell lines . |
| 0.9489 | 1.0000 | 1.0000 | As with the heterologous DNA binding domain , proteinMZF-1 represses reporter gene expression in nonhematopoietic cell lines and activates expression in hematopoietic cell lines . |
| As with the heterologous proteinDNA binding domain , MZF-1 represses reporter gene expression in nonhematopoietic cell lines and activates expression in hematopoietic cell lines . | |||
| As with the heterologous DNA binding domain , MZF-1 represses DNAreporter gene expression in nonhematopoietic cell lines and activates expression in hematopoietic cell lines . | |||
| As with the heterologous DNA binding domain , DNAMZF-1 represses reporter gene expression in nonhematopoietic cell lines and activates expression in hematopoietic cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1302 | 20.3582 | 10.7424 | Activation of CD34 expression in cell_linehematopoietic cell lines is dependent on the presence of intact MZF-1 binding sites . |
| 2.8950 | 20.4870 | 10.6426 | Activation of CD34 expression in hematopoietic cell lines is dependent on the presence of intact DNAMZF-1 binding sites . |
| 1.4171 | 10.7658 | 1.0000 | Activation of proteinCD34 expression in hematopoietic cell lines is dependent on the presence of intact MZF-1 binding sites . |
| 1.1823 | 10.5083 | 0.9936 | Activation of CD34 expression in hematopoietic cell lines is dependent on the presence of intact proteinMZF-1 binding sites . |
| Activation of CD34 expression in hematopoietic cell lines is dependent on the presence of intact DNAMZF-1 binding sites . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1050 | 20.2854 | 1.0000 | The cell type-specific regulation of the DNACD34 promoter by MZF-1 suggests the presence of tissue-specific regulators/adapters or differential MZF-1 modifications that determine MZF-1 transcriptional regulatory function . |
| 2.1244 | 20.4755 | 0.9999 | The cell type-specific regulation of the CD34 promoter by MZF-1 suggests the presence of proteintissue-specific regulators/adapters or differential MZF-1 modifications that determine MZF-1 transcriptional regulatory function . |
| 2.0253 | 20.3871 | 0.9905 | The cell type-specific regulation of the proteinCD34 promoter by MZF-1 suggests the presence of tissue-specific regulators/adapters or differential MZF-1 modifications that determine MZF-1 transcriptional regulatory function . |
| 1.6040 | 10.1808 | 1.0000 | The cell type-specific regulation of the CD34 promoter by MZF-1 suggests the presence of tissue-specific regulators/adapters or differential proteinMZF-1 modifications that determine MZF-1 transcriptional regulatory function . |
| 0.8584 | 1.0000 | 1.0000 | The cell type-specific regulation of the CD34 promoter by proteinMZF-1 suggests the presence of tissue-specific regulators/adapters or differential MZF-1 modifications that determine MZF-1 transcriptional regulatory function . |
| 0.8023 | 1.0000 | 1.0000 | The cell type-specific regulation of the CD34 promoter by MZF-1 suggests the presence of tissue-specific regulators/adapters or differential MZF-1 modifications that determine proteinMZF-1 transcriptional regulatory function . |
| The cell type-specific regulation of the CD34 promoter by MZF-1 suggests the presence of tissue-specific regulators/adapters or differential DNAMZF-1 modifications that determine MZF-1 transcriptional regulatory function . | |||
| The cell type-specific regulation of the CD34 promoter by MZF-1 suggests the presence of tissue-specific regulators/adapters or differential MZF-1 modifications that determine DNAMZF-1 transcriptional regulatory function . | |||
| The cell type-specific regulation of the CD34 promoter by DNAMZF-1 suggests the presence of tissue-specific regulators/adapters or differential MZF-1 modifications that determine MZF-1 transcriptional regulatory function . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2526 | 30.0859 | 10.9792 | The murine BCL6 gene is induced in activated lymphocytes as an DNAimmediate early gene . |
| 0.8001 | 1.0000 | 0.9999 | The murine BCL6 gene is induced in activated cell_typelymphocytes as an immediate early gene . |
| 0.6605 | 0.8676 | 0.9979 | The DNAmurine BCL6 gene is induced in activated lymphocytes as an immediate early gene . |
| The murine DNABCL6 gene is induced in activated lymphocytes as an immediate early gene . | |||
| The murine BCL6 gene is induced in cell_typeactivated lymphocytes as an immediate early gene . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0082 | 20.7960 | 10.9372 | The chromosomal translocation involving 3q27 is often detected in cell_typehuman B-cell lymphomas , especially diffuse lymphomas with a large-cell component . |
| 1.6909 | 10.8479 | 1.0000 | The chromosomal translocation involving DNA3q27 is often detected in human B-cell lymphomas , especially diffuse lymphomas with a large-cell component . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5956 | 10.8242 | 1.0000 | The DNABCL6 gene has been isolated from the chromosomal breakpoint in these lymphomas . |
| 1.8549 | 20.1690 | 1.0000 | The BCL6 gene has been isolated from the DNAchromosomal breakpoint in these lymphomas . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4738 | 30.2635 | 10.9017 | Here we cloned the murine BCL6 (mBCL6) cDNA from the muscle cDNA library using the DNAhuman BCL6 (hBCL6) cDNA as a probe. |
| 4.4504 | 20.9042 | 10.9421 | Here we cloned the DNAmurine BCL6 (mBCL6) cDNA from the muscle cDNA library using the human BCL6 (hBCL6) cDNA as a probe. |
| Here we cloned the murine BCL6 (mBCL6) cDNA from the DNAmuscle cDNA library using the human BCL6 (hBCL6) cDNA as a probe. | |||
| Here we cloned the proteinmurine BCL6 (mBCL6) cDNA from the muscle cDNA library using the human BCL6 (hBCL6) cDNA as a probe. | |||
| Here we cloned the murine BCL6 (mBCL6) cDNA from the muscle cDNA library using the proteinhuman BCL6 (hBCL6) cDNA as a probe. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3601 | 10.9096 | 1.0000 | The predicted amino acid sequence was 95% identical to that of proteinhBCL6 . |
| 4.1643 | 20.4346 | 10.9622 | The predicted proteinamino acid sequence was 95% identical to that of hBCL6 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3881 | 20.9212 | 1.0000 | It contains six repeats of the proteinKruppel-like zinc-finger motif that are completely identical to those of hBCL6 , indicating that the BCL6 gene is well conserved between humans and mice . |
| 1.5614 | 10.6621 | 1.0000 | It contains six repeats of the Kruppel-like zinc-finger motif that are completely identical to those of proteinhBCL6 , indicating that the BCL6 gene is well conserved between humans and mice . |
| 1.4738 | 20.8023 | 1.0000 | It contains six repeats of the Kruppel-like zinc-finger motif that are completely identical to those of hBCL6 , indicating that the DNABCL6 gene is well conserved between humans and mice . |
| 1.3983 | 20.8399 | 0.9892 | It contains six repeats of the Kruppel-like zinc-finger motif that are completely identical to those of hBCL6 , indicating that the proteinBCL6 gene is well conserved between humans and mice . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2595 | 20.3658 | 1.0000 | Expression of the DNAmBCL6 gene was ubiquitously detected in adult mouse tissues including lymphatic organs . |
| 2.0463 | 20.3073 | 0.9919 | Expression of the proteinmBCL6 gene was ubiquitously detected in adult mouse tissues including lymphatic organs . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7667 | 10.7387 | 1.0000 | Furthermore, it was induced in cell_typelymphocytes activated with phorbol ester and Ca2+ ionophore within 30 min after stimulation. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9419 | 20.1515 | 0.9998 | These results suggest that BCL6 plays a role in cell_typeactivated lymphocytes as an immediate early gene. |
| 1.4610 | 10.8433 | 1.0000 | These results suggest that proteinBCL6 plays a role in activated lymphocytes as an immediate early gene. |
| 0.8428 | 1.0000 | 0.9999 | These results suggest that BCL6 plays a role in activated cell_typelymphocytes as an immediate early gene. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7804 | 20.7795 | 0.9986 | The role of proteinBSAP ( Pax-5 ) in B-cell development . |
| 0.9028 | 0.9999 | 0.9998 | The role of BSAP ( proteinPax-5 ) in B-cell development . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.2403 | 30.1563 | 10.6722 | In this manner, the paired box containing gene Pax-5 , encoding the proteinB cell specific transcription factor BSAP , has been shown to play a key role in early B lymphopoiesis . |
| 3.2644 | 30.8376 | 10.3615 | In this manner, the DNApaired box containing gene Pax-5 , encoding the B cell specific transcription factor BSAP , has been shown to play a key role in early B lymphopoiesis . |
| 0.9715 | 0.9999 | 1.0000 | In this manner, the paired box containing gene Pax-5 , encoding the B cell specific transcription factor proteinBSAP , has been shown to play a key role in early B lymphopoiesis . |
| 0.9454 | 0.9997 | 1.0000 | In this manner, the paired box containing gene DNAPax-5 , encoding the B cell specific transcription factor BSAP , has been shown to play a key role in early B lymphopoiesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6982 | 30.0149 | 0.9325 | Other experimental strategies have implicated BSAP in the control of cell proliferation , isotype switching and transcription of the proteinimmunoglobulin heavy-chain gene at late stages of B-cell differentiation . |
| 2.1852 | 20.9727 | 0.9999 | Other experimental strategies have implicated BSAP in the control of cell proliferation , isotype switching and transcription of the DNAimmunoglobulin heavy-chain gene at late stages of B-cell differentiation . |
| 1.6232 | 10.8656 | 1.0000 | Other experimental strategies have implicated proteinBSAP in the control of cell proliferation , isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of B-cell differentiation . |
| 0.6834 | 0.9999 | 0.9998 | Other experimental strategies have implicated BSAP in the control of cell proliferation , isotype switching and transcription of the immunoglobulin heavy-chain gene at late stages of cell_typeB-cell differentiation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3374 | 20.9945 | 10.2572 | The DNA-binding properties of two heat shock factors , HSF1 and HSF3 , are induced in the cell_lineavian erythroblast cell line HD6 . |
| 0.9399 | 1.0000 | 1.0000 | The DNA-binding properties of two heat shock factors , HSF1 and proteinHSF3 , are induced in the avian erythroblast cell line HD6 . |
| 0.9106 | 1.0000 | 1.0000 | The DNA-binding properties of two heat shock factors , proteinHSF1 and HSF3 , are induced in the avian erythroblast cell line HD6 . |
| 0.9071 | 0.9990 | 0.9998 | The DNA-binding properties of two heat shock factors , HSF1 and HSF3 , are induced in the avian erythroblast cell line cell_lineHD6 . |
| 4.0031 | 30.2897 | 20.0847 | The DNA-binding properties of two heat shock factors , HSF1 and HSF3 , are induced in the cell_lineavian erythroblast cell line HD6 . |
| 3.1405 | 20.5221 | 10.5332 | The DNA-binding properties of two proteinheat shock factors , HSF1 and HSF3 , are induced in the avian erythroblast cell line HD6 . |
| The DNA-binding properties of proteintwo heat shock factors , HSF1 and HSF3 , are induced in the avian erythroblast cell line HD6 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.8478 | 30.3131 | 20.4121 | Avian cells express three DNAheat shock transcription factor ( HSF ) genes corresponding to a novel factor , HSF3 , and homologs of mouse and human HSF1 and HSF2 . |
| 2.5892 | 40.4744 | 10.3972 | Avian cells express three proteinheat shock transcription factor ( HSF ) genes corresponding to a novel factor , HSF3 , and homologs of mouse and human HSF1 and HSF2 . |
| 1.7134 | 10.4470 | 1.0000 | Avian cells express three heat shock transcription factor ( HSF ) genes corresponding to a novel factor , proteinHSF3 , and homologs of mouse and human HSF1 and HSF2 . |
| 1.1132 | 10.2503 | 1.0000 | Avian cells express three heat shock transcription factor ( HSF ) genes corresponding to a proteinnovel factor , HSF3 , and homologs of mouse and human HSF1 and HSF2 . |
| 0.9592 | 1.0000 | 0.9860 | Avian cells express three heat shock transcription factor ( proteinHSF ) genes corresponding to a novel factor , HSF3 , and homologs of mouse and human HSF1 and HSF2 . |
| 0.8458 | 1.0000 | 1.0000 | Avian cells express three heat shock transcription factor ( HSF ) genes corresponding to a novel factor , HSF3 , and homologs of mouse and human HSF1 and proteinHSF2 . |
| Avian cells express three heat shock transcription factor ( HSF ) genes corresponding to a novel factor , HSF3 , and homologs of mouse and human proteinHSF1 and HSF2 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7149 | 10.6728 | 1.0000 | Analysis of the biochemical and cell biological properties of these HSFs reveals that proteinHSF3 has properties in common with both HSF1 and HSF2 and yet has features which are distinct from both. |
| 1.6985 | 10.7443 | 1.0000 | Analysis of the biochemical and cell biological properties of these HSFs reveals that HSF3 has properties in common with both proteinHSF1 and HSF2 and yet has features which are distinct from both. |
| 1.6108 | 10.8744 | 1.0000 | Analysis of the biochemical and cell biological properties of these proteinHSFs reveals that HSF3 has properties in common with both HSF1 and HSF2 and yet has features which are distinct from both. |
| 0.9459 | 1.0000 | 1.0000 | Analysis of the biochemical and cell biological properties of these HSFs reveals that HSF3 has properties in common with both HSF1 and proteinHSF2 and yet has features which are distinct from both. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6976 | 20.6325 | 10.9675 | HSF3 is constitutively expressed in the erythroblast cell line HD6 , the cell_linelymphoblast cell line MSB , and embryo fibroblasts , and yet its DNA-binding activity is induced only upon exposure of HD6 cells to heat shock. |
| 4.6395 | 20.9904 | 10.4224 | HSF3 is constitutively expressed in the cell_lineerythroblast cell line HD6 , the lymphoblast cell line MSB , and embryo fibroblasts , and yet its DNA-binding activity is induced only upon exposure of HD6 cells to heat shock. |
| 0.9643 | 1.0000 | 1.0000 | proteinHSF3 is constitutively expressed in the erythroblast cell line HD6 , the lymphoblast cell line MSB , and embryo fibroblasts , and yet its DNA-binding activity is induced only upon exposure of HD6 cells to heat shock. |
| 2.1034 | 20.7446 | 0.9999 | HSF3 is constitutively expressed in the erythroblast cell line HD6 , the lymphoblast cell line MSB , and embryo fibroblasts , and yet its DNA-binding activity is induced only upon exposure of cell_lineHD6 cells to heat shock. |
| 1.9629 | 20.0864 | 0.9996 | HSF3 is constitutively expressed in the erythroblast cell line HD6 , the lymphoblast cell line MSB , and cell_typeembryo fibroblasts , and yet its DNA-binding activity is induced only upon exposure of HD6 cells to heat shock. |
| HSF3 is constitutively expressed in the erythroblast cell line HD6 , the lymphoblast cell line MSB , and cell_lineembryo fibroblasts , and yet its DNA-binding activity is induced only upon exposure of HD6 cells to heat shock. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2129 | 20.3586 | 0.9999 | Acquisition of HSF3 DNA-binding activity in HD6 cells is accompanied by oligomerization from a proteinnon-DNA-binding dimer to a DNA-binding trimer , whereas the effect of heat shock on HSF1 is oligomerization of an inert monomer to a DNA-binding trimer . |
| 1.5779 | 10.5109 | 1.0000 | Acquisition of HSF3 DNA-binding activity in HD6 cells is accompanied by oligomerization from a non-DNA-binding dimer to a DNA-binding trimer , whereas the effect of heat shock on proteinHSF1 is oligomerization of an inert monomer to a DNA-binding trimer . |
| 1.5004 | 10.9110 | 0.9999 | Acquisition of HSF3 DNA-binding activity in cell_lineHD6 cells is accompanied by oligomerization from a non-DNA-binding dimer to a DNA-binding trimer , whereas the effect of heat shock on HSF1 is oligomerization of an inert monomer to a DNA-binding trimer . |
| 1.4756 | 10.9400 | 0.9999 | Acquisition of HSF3 DNA-binding activity in HD6 cells is accompanied by oligomerization from a non-DNA-binding dimer to a proteinDNA-binding trimer , whereas the effect of heat shock on HSF1 is oligomerization of an inert monomer to a DNA-binding trimer . |
| 1.4753 | 10.6386 | 1.0000 | Acquisition of proteinHSF3 DNA-binding activity in HD6 cells is accompanied by oligomerization from a non-DNA-binding dimer to a DNA-binding trimer , whereas the effect of heat shock on HSF1 is oligomerization of an inert monomer to a DNA-binding trimer . |
| 1.4591 | 10.8418 | 0.9999 | Acquisition of HSF3 DNA-binding activity in HD6 cells is accompanied by oligomerization from a non-DNA-binding dimer to a DNA-binding trimer , whereas the effect of heat shock on HSF1 is oligomerization of an inert monomer to a proteinDNA-binding trimer . |
| Acquisition of HSF3 DNA-binding activity in HD6 cells is accompanied by oligomerization from a non-DNA-binding dimer to a DNA-binding trimer , whereas the effect of heat shock on HSF1 is oligomerization of an proteininert monomer to a DNA-binding trimer . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5022 | 10.9360 | 1.0000 | Induction of proteinHSF3 DNA-binding activity is delayed compared with that of HSF1 . |
| 1.3722 | 10.9664 | 1.0000 | Induction of HSF3 DNA-binding activity is delayed compared with that of proteinHSF1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3333 | 20.0531 | 1.0000 | As occurs for proteinHSF1 , heat shock leads to the translocation of HSF3 to the nucleus. |
| 1.5812 | 10.6708 | 1.0000 | As occurs for HSF1 , heat shock leads to the translocation of proteinHSF3 to the nucleus. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.3595 | 30.0470 | 10.3494 | HSF exhibits the properties of a transcriptional activator , as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a DNAheat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4 -HSF3 protein on a GAL4 reporter construct . |
| 4.6176 | 30.0254 | 10.8747 | HSF exhibits the properties of a transcriptional activator , as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a proteinchimeric GAL4 -HSF3 protein on a GAL4 reporter construct . |
| 3.2699 | 20.8222 | 10.8844 | HSF exhibits the properties of a transcriptional activator , as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4 -HSF3 protein on a DNAGAL4 reporter construct . |
| 1.9963 | 20.0772 | 1.0000 | HSF exhibits the properties of a proteintranscriptional activator , as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4 -HSF3 protein on a GAL4 reporter construct . |
| 1.5200 | 10.1266 | 1.0000 | HSF exhibits the properties of a transcriptional activator , as judged from the stimulatory activity of transiently overexpressed proteinHSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4 -HSF3 protein on a GAL4 reporter construct . |
| 0.5312 | 1.0000 | 0.9492 | HSF exhibits the properties of a transcriptional activator , as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4 protein-HSF3 protein on a GAL4 reporter construct . |
| 0.8837 | 1.0000 | 1.0000 | proteinHSF exhibits the properties of a transcriptional activator , as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4 -HSF3 protein on a GAL4 reporter construct . |
| HSF exhibits the properties of a transcriptional activator , as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric proteinGAL4 -HSF3 protein on a GAL4 reporter construct . | |||
| HSF exhibits the properties of a transcriptional activator , as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4 -HSF3 protein on a proteinGAL4 reporter construct . | |||
| HSF exhibits the properties of a transcriptional activator , as judged from the stimulatory activity of proteintransiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4 -HSF3 protein on a GAL4 reporter construct . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8864 | 1.0000 | 1.0000 | These results reveal that proteinHSF3 is negatively regulated in avian cells and acquires DNA-binding activity in certain cells upon heat shock . |
| These results reveal that HSF3 is negatively regulated in cell_typeavian cells and acquires DNA-binding activity in certain cells upon heat shock . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3852 | 20.2467 | 10.5259 | Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific proteinNFATp polyclonal antibody . |
| 1.3487 | 10.5081 | 1.0000 | Direct demonstration of proteinNFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody . |
| 1.2668 | 10.3005 | 0.9964 | Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific proteinNFATp polyclonal antibody . |
| Direct demonstration of NFATp dephosphorylation and nuclear localization in cell_lineactivated HT-2 cells using a specific NFATp polyclonal antibody . | |||
| Direct demonstration of NFATp dephosphorylation and nuclear localization in activated cell_lineHT-2 cells using a specific NFATp polyclonal antibody . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5540 | 0.9988 | 20.7060 | proteinNuclear factor of activated T cells ( NFAT ) regulates transcription of a number of cytokine genes , and NFAT DNA binding activity is stimulated following T cell activation . |
| 1.5266 | 10.1391 | 1.0000 | Nuclear factor of activated T cells ( NFAT ) regulates transcription of a number of cytokine genes , and proteinNFAT DNA binding activity is stimulated following T cell activation . |
| 0.9761 | 1.0000 | 1.0000 | Nuclear factor of activated T cells ( proteinNFAT ) regulates transcription of a number of cytokine genes , and NFAT DNA binding activity is stimulated following T cell activation . |
| 2.0128 | 20.5638 | 0.9999 | Nuclear factor of activated T cells ( NFAT ) regulates transcription of a number of DNAcytokine genes , and NFAT DNA binding activity is stimulated following T cell activation . |
| Nuclear factor of activated T cells ( NFAT ) regulates transcription of a number of proteincytokine genes , and NFAT DNA binding activity is stimulated following T cell activation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6045 | 10.7318 | 1.0000 | Several lines of evidence have suggested that proteinNFAT is a substrate for calcineurin , a serine/threonine phosphatase . |
| 1.4997 | 10.7551 | 1.0000 | Several lines of evidence have suggested that NFAT is a substrate for proteincalcineurin , a serine/threonine phosphatase . |
| 1.4147 | 10.3013 | 0.9999 | Several lines of evidence have suggested that NFAT is a substrate for calcineurin , a proteinserine/threonine phosphatase . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.1605 | 10.5388 | 0.9999 | Using a polyclonal antibody to proteinmurine NFATp , Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa NFATp protein was highly expressed in thymus and spleen . |
| 0.9263 | 1.0000 | 0.9891 | Using a polyclonal antibody to murine NFATp , Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa proteinNFATp protein was highly expressed in thymus and spleen . |
| 0.9116 | 1.0000 | 1.0000 | Using a polyclonal antibody to murine proteinNFATp , Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa NFATp protein was highly expressed in thymus and spleen . |
| 2.3411 | 20.9259 | 0.9999 | Using a polyclonal antibody to murine NFATp , Western blot analysis of various mouse tissues demonstrated that the protein110-130-kDa NFATp protein was highly expressed in thymus and spleen . |
| 1.9800 | 20.5329 | 0.9999 | Using a proteinpolyclonal antibody to murine NFATp , Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa NFATp protein was highly expressed in thymus and spleen . |
| Using a polyclonal antibody to murine NFATp , Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa proteinNFATp protein was highly expressed in thymus and spleen . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5737 | 10.0859 | 1.0000 | Treatment of immunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp , demonstrating that proteinNFATp is an in vitro substrate for calcineurin . |
| 1.4988 | 10.4673 | 1.0000 | Treatment of immunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of proteinNFATp , demonstrating that NFATp is an in vitro substrate for calcineurin . |
| 1.4568 | 10.8854 | 1.0000 | Treatment of immunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp , demonstrating that NFATp is an in vitro substrate for proteincalcineurin . |
| 0.9061 | 1.0000 | 1.0000 | Treatment of immunoprecipitated NFATp from untreated HT-2 cells with proteincalcineurin resulted in the dephosphorylation of NFATp , demonstrating that NFATp is an in vitro substrate for calcineurin . |
| 0.9030 | 1.0000 | 1.0000 | Treatment of immunoprecipitated proteinNFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp , demonstrating that NFATp is an in vitro substrate for calcineurin . |
| 3.1106 | 10.5548 | 10.8765 | Treatment of immunoprecipitated NFATp from cell_lineuntreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp , demonstrating that NFATp is an in vitro substrate for calcineurin . |
| 1.9857 | 20.5340 | 0.9998 | Treatment of proteinimmunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp , demonstrating that NFATp is an in vitro substrate for calcineurin . |
| Treatment of immunoprecipitated NFATp from untreated cell_lineHT-2 cells with calcineurin resulted in the dephosphorylation of NFATp , demonstrating that NFATp is an in vitro substrate for calcineurin . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9375 | 20.6200 | 10.8286 | NFATp immunoprecipitated from cell_line32P-labeled HT-2 cells migrated as an approximately 120-kDa protein that was localized to the cytosol of the cells. |
| 0.9700 | 1.0000 | 1.0000 | proteinNFATp immunoprecipitated from 32P-labeled HT-2 cells migrated as an approximately 120-kDa protein that was localized to the cytosol of the cells. |
| 2.1691 | 20.5180 | 1.0000 | NFATp immunoprecipitated from 32P-labeled HT-2 cells migrated as an approximately protein120-kDa protein that was localized to the cytosol of the cells. |
| NFATp immunoprecipitated from 32P-labeled cell_lineHT-2 cells migrated as an approximately 120-kDa protein that was localized to the cytosol of the cells. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6512 | 10.9664 | 1.0000 | Treatment of the cells with ionomycin resulted in a decrease in the molecular weight of proteinNFATp and a loss of 32P , consistent with NFATp dephosphorylation . |
| 1.6506 | 10.5120 | 1.0000 | Treatment of the cells with ionomycin resulted in a decrease in the molecular weight of NFATp and a loss of 32P , consistent with proteinNFATp dephosphorylation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6606 | 10.9432 | 1.0000 | The dephosphorylation of proteinNFATp was accompanied by localization of the protein to the nuclear fraction . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6523 | 10.6311 | 1.0000 | Both of these events were blocked by preincubation of the cells with FK506 , a calcineurin inhibitor , consistent with the hypothesis that proteinNFATp is a calcineurin substrate in cells. |
| 1.5909 | 10.4345 | 1.0000 | Both of these events were blocked by preincubation of the cells with FK506 , a proteincalcineurin inhibitor , consistent with the hypothesis that NFATp is a calcineurin substrate in cells. |
| 1.5004 | 10.5621 | 0.9937 | Both of these events were blocked by preincubation of the cells with FK506 , a calcineurin inhibitor , consistent with the hypothesis that NFATp is a proteincalcineurin substrate in cells. |
| 1.5452 | 10.6312 | 0.9999 | Both of these events were blocked by preincubation of the cells with FK506 , a calcineurin inhibitor , consistent with the hypothesis that NFATp is a proteincalcineurin substrate in cells. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.2584 | 30.1920 | 10.9784 | Activation and expression of the nuclear factors of activated T cells , NFATp and NFATc , in cell_typehuman natural killer cells : regulation upon CD16 ligand binding . |
| 0.9515 | 1.0000 | 1.0000 | Activation and expression of the nuclear factors of activated T cells , proteinNFATp and NFATc , in human natural killer cells : regulation upon CD16 ligand binding . |
| 0.9460 | 1.0000 | 1.0000 | Activation and expression of the nuclear factors of activated T cells , NFATp and proteinNFATc , in human natural killer cells : regulation upon CD16 ligand binding . |
| 0.7770 | 1.0000 | 1.0000 | Activation and expression of the nuclear factors of activated T cells , NFATp and NFATc , in human natural killer cells : regulation upon proteinCD16 ligand binding . |
| 6.9409 | 30.9905 | 20.6418 | Activation and expression of the proteinnuclear factors of activated T cells , NFATp and NFATc , in human natural killer cells : regulation upon CD16 ligand binding . |
| Activation and expression of the proteinnuclear factors of activated T cells , NFATp and NFATc , in human natural killer cells : regulation upon CD16 ligand binding . | |||
| Activation and expression of the nuclear factors of cell_typeactivated T cells , NFATp and NFATc , in human natural killer cells : regulation upon CD16 ligand binding . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6682 | 20.9372 | 10.7439 | The putative factors that couple the signal transduction from surface receptors to the activation of cytokine synthesis in cell_typenatural killer (NK) cells have not been elucidated. |
| 1.5888 | 10.1756 | 1.0000 | The putative factors that couple the signal transduction from surface receptors to the activation of proteincytokine synthesis in natural killer (NK) cells have not been elucidated. |
| 2.0307 | 20.7074 | 0.9999 | The putative factors that couple the signal transduction from proteinsurface receptors to the activation of cytokine synthesis in natural killer (NK) cells have not been elucidated. |
| 0.5248 | 0.9751 | 0.9999 | The proteinputative factors that couple the signal transduction from surface receptors to the activation of cytokine synthesis in natural killer (NK) cells have not been elucidated. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.2208 | 20.5860 | 20.9552 | We report here that the nuclear factor of activated T cells ( NFATp ), a proteincyclosporin A ( CsA )-sensitive factor that regulates the transcription of several cytokines , mediates CD16 -induced activation of cytokine genes in human NK cells . |
| 1.3108 | 10.1006 | 0.9947 | We report here that the nuclear factor of activated T cells ( NFATp ), a cyclosporin A ( CsA )-sensitive factor that regulates the transcription of several cytokines , mediates CD16 -induced activation of cytokine genes in cell_typehuman NK cells . |
| 0.9650 | 1.0000 | 1.0000 | We report here that the nuclear factor of activated T cells ( proteinNFATp ), a cyclosporin A ( CsA )-sensitive factor that regulates the transcription of several cytokines , mediates CD16 -induced activation of cytokine genes in human NK cells . |
| 0.9100 | 1.0000 | 1.0000 | We report here that the nuclear factor of activated T cells ( NFATp ), a cyclosporin A ( CsA )-sensitive factor that regulates the transcription of several cytokines , mediates proteinCD16 -induced activation of cytokine genes in human NK cells . |
| 0.7860 | 0.9999 | 1.0000 | We report here that the nuclear factor of activated T cells ( NFATp ), a cyclosporin A ( CsA )-sensitive factor that regulates the transcription of several proteincytokines , mediates CD16 -induced activation of cytokine genes in human NK cells . |
| 6.9784 | 30.9563 | 20.8680 | We report here that the proteinnuclear factor of activated T cells ( NFATp ), a cyclosporin A ( CsA )-sensitive factor that regulates the transcription of several cytokines , mediates CD16 -induced activation of cytokine genes in human NK cells . |
| 2.0105 | 20.6346 | 0.9998 | We report here that the nuclear factor of activated T cells ( NFATp ), a cyclosporin A ( CsA )-sensitive factor that regulates the transcription of several cytokines , mediates CD16 -induced activation of DNAcytokine genes in human NK cells . |
| We report here that the nuclear factor of cell_typeactivated T cells ( NFATp ), a cyclosporin A ( CsA )-sensitive factor that regulates the transcription of several cytokines , mediates CD16 -induced activation of cytokine genes in human NK cells . | |||
| We report here that the proteinnuclear factor of activated T cells ( NFATp ), a cyclosporin A ( CsA )-sensitive factor that regulates the transcription of several cytokines , mediates CD16 -induced activation of cytokine genes in human NK cells . | |||
| We report here that the nuclear factor of activated T cells ( NFATp ), a cyclosporin A ( CsA )-sensitive factor that regulates the transcription of several cytokines , mediates CD16 -induced activation of proteincytokine genes in human NK cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1196 | 10.6773 | 10.5322 | CD16 ( proteinFc gamma RIIIA )-induced expression of cytokine mRNA in NK cells occurs via a CsA -sensitive and Ca(2+)-dependent mechanism . |
| 1.5673 | 10.7457 | 0.9999 | CD16 ( Fc gamma RIIIA )-induced expression of RNAcytokine mRNA in NK cells occurs via a CsA -sensitive and Ca(2+)-dependent mechanism . |
| 1.4880 | 10.7579 | 0.9998 | CD16 ( Fc gamma RIIIA )-induced expression of cytokine mRNA in cell_typeNK cells occurs via a CsA -sensitive and Ca(2+)-dependent mechanism . |
| 0.9619 | 1.0000 | 1.0000 | proteinCD16 ( Fc gamma RIIIA )-induced expression of cytokine mRNA in NK cells occurs via a CsA -sensitive and Ca(2+)-dependent mechanism . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7720 | 10.0198 | 1.0000 | Stimulation of NK cells with proteinCD16 ligands induces NFAT -like DNA binding activity in the nuclear extracts from these cells, as detected in electrophoretic mobility shift assays . |
| 1.6216 | 10.9232 | 0.9999 | Stimulation of cell_typeNK cells with CD16 ligands induces NFAT -like DNA binding activity in the nuclear extracts from these cells, as detected in electrophoretic mobility shift assays . |
| 0.9480 | 1.0000 | 1.0000 | Stimulation of NK cells with CD16 ligands induces proteinNFAT -like DNA binding activity in the nuclear extracts from these cells, as detected in electrophoretic mobility shift assays . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2015 | 20.1394 | 0.9999 | NK cell NFAT is present in the cytosol of cell_typenonstimulated cells , migrates to the nucleus upon stimulation, and can associate with AP-1 . |
| 1.7289 | 0.9989 | 10.7045 | proteinNK cell NFAT is present in the cytosol of nonstimulated cells , migrates to the nucleus upon stimulation, and can associate with AP-1 . |
| 1.5046 | 10.9597 | 1.0000 | NK cell NFAT is present in the cytosol of nonstimulated cells , migrates to the nucleus upon stimulation, and can associate with proteinAP-1 . |
| 0.9511 | 1.0000 | 1.0000 | NK cell proteinNFAT is present in the cytosol of nonstimulated cells , migrates to the nucleus upon stimulation, and can associate with AP-1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6242 | 10.6334 | 1.0000 | Two distinct molecules, proteinNFATp and NFATc , have been reported to mediate NFAT activity . |
| 1.5045 | 10.9764 | 1.0000 | Two distinct molecules, NFATp and NFATc , have been reported to mediate proteinNFAT activity . |
| 0.8877 | 1.0000 | 1.0000 | Two distinct molecules, NFATp and proteinNFATc , have been reported to mediate NFAT activity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4362 | 20.5471 | 0.9999 | The results of supershift assays using NFATp- and NFATc- specific antibodies indicate that NK cell activation early after CD16 ligand binding involves primarily, if not exclusively, NFATp , and Western blot analysis shows that this has the same electrophoretic mobility (approximately 120 kD) as that of cell_typeT lymphocytes . |
| 1.7659 | 10.3783 | 1.0000 | The results of supershift assays using NFATp- and NFATc- specific antibodies indicate that NK cell activation early after CD16 ligand binding involves primarily, if not exclusively, proteinNFATp , and Western blot analysis shows that this has the same electrophoretic mobility (approximately 120 kD) as that of T lymphocytes . |
| 0.8787 | 1.0000 | 1.0000 | The results of supershift assays using NFATp- and NFATc- specific antibodies indicate that NK cell activation early after proteinCD16 ligand binding involves primarily, if not exclusively, NFATp , and Western blot analysis shows that this has the same electrophoretic mobility (approximately 120 kD) as that of T lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7156 | 10.7728 | 1.0000 | NK cells do not express NFATc constitutively, but RNANFATc mRNA accumulation is induced in these cells within 2 h of stimulation with CD16 ligands . |
| 1.4810 | 10.7732 | 0.9963 | NK cells do not express NFATc constitutively, but proteinNFATc mRNA accumulation is induced in these cells within 2 h of stimulation with CD16 ligands . |
| 0.8972 | 0.9995 | 0.9998 | cell_typeNK cells do not express NFATc constitutively, but NFATc mRNA accumulation is induced in these cells within 2 h of stimulation with CD16 ligands . |
| 0.8244 | 1.0000 | 1.0000 | NK cells do not express proteinNFATc constitutively, but NFATc mRNA accumulation is induced in these cells within 2 h of stimulation with CD16 ligands . |
| 1.6710 | 10.3800 | 1.0000 | NK cells do not express NFATc constitutively, but NFATc mRNA accumulation is induced in these cells within 2 h of stimulation with proteinCD16 ligands . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1953 | 20.6956 | 0.9935 | However, supershift assays using the available mAb recognizing the T cell NFATc revealed no detectable proteinNFATc protein in nuclear and cytoplasmic extracts from CD16- or phorbol ester -stimulated cells at any time tested, up to 4 h. |
| 2.0877 | 20.2264 | 0.9999 | However, supershift assays using the available mAb recognizing the proteinT cell NFATc revealed no detectable NFATc protein in nuclear and cytoplasmic extracts from CD16- or phorbol ester -stimulated cells at any time tested, up to 4 h. |
| 1.7488 | 10.9182 | 10.7372 | However, supershift assays using the available mAb recognizing the T cell NFATc revealed no detectable NFATc protein in nuclear and cytoplasmic extracts from CD16- or cell_linephorbol ester -stimulated cells at any time tested, up to 4 h. |
| 0.9444 | 0.9999 | 1.0000 | However, supershift assays using the available mAb recognizing the T cell proteinNFATc revealed no detectable NFATc protein in nuclear and cytoplasmic extracts from CD16- or phorbol ester -stimulated cells at any time tested, up to 4 h. |
| 0.8456 | 0.9998 | 1.0000 | However, supershift assays using the available proteinmAb recognizing the T cell NFATc revealed no detectable NFATc protein in nuclear and cytoplasmic extracts from CD16- or phorbol ester -stimulated cells at any time tested, up to 4 h. |
| 2.1687 | 20.2122 | 1.0000 | However, supershift assays using the available mAb recognizing the T cell NFATc revealed no detectable proteinNFATc protein in nuclear and cytoplasmic extracts from CD16- or phorbol ester -stimulated cells at any time tested, up to 4 h. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5923 | 30.0956 | 10.3639 | These results provide the first direct evidence that both proteinCsA -sensitive transcription factors , NFATp and NFATc , are expressed in human NK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells , results in early activation of NFATp and subsequently induced expression of NFATc mRNA . |
| 2.5243 | 20.7562 | 1.0000 | These results provide the first direct evidence that both CsA -sensitive transcription factors , NFATp and NFATc , are expressed in human NK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells , results in early activation of NFATp and subsequently induced expression of RNANFATc mRNA . |
| 2.1291 | 20.9439 | 0.9922 | These results provide the first direct evidence that both CsA -sensitive transcription factors , NFATp and NFATc , are expressed in human NK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells , results in early activation of NFATp and subsequently induced expression of proteinNFATc mRNA . |
| 1.6894 | 10.0189 | 1.0000 | These results provide the first direct evidence that both CsA -sensitive transcription factors , NFATp and NFATc , are expressed in human NK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells , results in early activation of proteinNFATp and subsequently induced expression of NFATc mRNA . |
| 1.6370 | 10.6313 | 0.9999 | These results provide the first direct evidence that both CsA -sensitive transcription factors , NFATp and NFATc , are expressed in human NK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in cell_typeNK cells , results in early activation of NFATp and subsequently induced expression of NFATc mRNA . |
| 1.4095 | 1.0000 | 10.0967 | These results provide the first direct evidence that both CsA -sensitive transcription factors , NFATp and NFATc , are expressed in human cell_typeNK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells , results in early activation of NFATp and subsequently induced expression of NFATc mRNA . |
| 0.9490 | 1.0000 | 1.0000 | These results provide the first direct evidence that both CsA -sensitive transcription factors , proteinNFATp and NFATc , are expressed in human NK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells , results in early activation of NFATp and subsequently induced expression of NFATc mRNA . |
| 0.9085 | 1.0000 | 1.0000 | These results provide the first direct evidence that both CsA -sensitive transcription factors , NFATp and proteinNFATc , are expressed in human NK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells , results in early activation of NFATp and subsequently induced expression of NFATc mRNA . |
| 0.8367 | 0.9987 | 0.9999 | These results provide the first direct evidence that both CsA -sensitive proteintranscription factors , NFATp and NFATc , are expressed in human NK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells , results in early activation of NFATp and subsequently induced expression of NFATc mRNA . |
| 3.6920 | 20.7811 | 10.6788 | These results provide the first direct evidence that both CsA -sensitive transcription factors , NFATp and NFATc , are expressed in cell_typehuman NK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of CD16 in NK cells , results in early activation of NFATp and subsequently induced expression of NFATc mRNA . |
| 2.1635 | 20.2297 | 0.9998 | These results provide the first direct evidence that both CsA -sensitive transcription factors , NFATp and NFATc , are expressed in human NK cells , and that their activation and/or expression can be regulated in cell_typeprimary cells by a single stimulus, that, in the case of CD16 in NK cells , results in early activation of NFATp and subsequently induced expression of NFATc mRNA . |
| 0.8523 | 1.0000 | 1.0000 | These results provide the first direct evidence that both CsA -sensitive transcription factors , NFATp and NFATc , are expressed in human NK cells , and that their activation and/or expression can be regulated in primary cells by a single stimulus, that, in the case of proteinCD16 in NK cells , results in early activation of NFATp and subsequently induced expression of NFATc mRNA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1004 | 20.2721 | 0.9999 | Interleukin 2 signaling involves the phosphorylation of proteinStat proteins . |
| 0.9061 | 0.9999 | 1.0000 | proteinInterleukin 2 signaling involves the phosphorylation of Stat proteins . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0184 | 10.6414 | 10.9782 | One of the most important cytokines involved in immune response regulation is interleukin 2 (IL-2), a potent activator of the proliferation and function of T lymphocytes and cell_typenatural killer cells . |
| 2.1564 | 20.1425 | 10.1263 | One of the most important cytokines involved in immune response regulation is interleukin 2 (IL-2), a potent activator of the proliferation and function of cell_typeT lymphocytes and natural killer cells . |
| 0.8675 | 0.9999 | 1.0000 | One of the most important proteincytokines involved in immune response regulation is interleukin 2 (IL-2), a potent activator of the proliferation and function of T lymphocytes and natural killer cells . |
| 2.2104 | 20.7964 | 0.9997 | One of the most important cytokines involved in immune response regulation is proteininterleukin 2 (IL-2), a potent activator of the proliferation and function of T lymphocytes and natural killer cells . |
| One of the most important cytokines involved in immune response regulation is interleukin 2 (IL-2), a potent activator of the proliferation and function of T cell_typelymphocytes and natural killer cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6458 | 10.7521 | 1.0000 | The mechanisms by which the effects of proteinIL-2 are propagated within cells are not understood. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7493 | 10.3313 | 1.0000 | While the binding of proteinIL-2 to its receptor was recently shown to lead to the activation of two kinases , Jak-1 and Jak-3 , subsequent steps in the signaling pathway to the nucleus that lead to the activation of specific genes had not been characterized. |
| 0.9809 | 1.0000 | 1.0000 | While the binding of IL-2 to its receptor was recently shown to lead to the activation of two kinases , Jak-1 and proteinJak-3 , subsequent steps in the signaling pathway to the nucleus that lead to the activation of specific genes had not been characterized. |
| 0.9531 | 1.0000 | 1.0000 | While the binding of IL-2 to its receptor was recently shown to lead to the activation of two kinases , proteinJak-1 and Jak-3 , subsequent steps in the signaling pathway to the nucleus that lead to the activation of specific genes had not been characterized. |
| 0.8937 | 1.0000 | 1.0000 | While the binding of IL-2 to its receptor was recently shown to lead to the activation of two proteinkinases , Jak-1 and Jak-3 , subsequent steps in the signaling pathway to the nucleus that lead to the activation of specific genes had not been characterized. |
| 0.6918 | 1.0000 | 1.0000 | While the binding of IL-2 to its proteinreceptor was recently shown to lead to the activation of two kinases , Jak-1 and Jak-3 , subsequent steps in the signaling pathway to the nucleus that lead to the activation of specific genes had not been characterized. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7460 | 10.6086 | 1.0000 | Since many proteincytokines that activate Jak kinases also lead to the tyrosine phosphorylation and activation of members of the Stat family of transcription factors , the ability of IL-2 to trigger Stat phosphorylation was examined. |
| 1.6792 | 10.0222 | 1.0000 | Since many cytokines that activate Jak kinases also lead to the tyrosine phosphorylation and activation of members of the Stat family of transcription factors , the ability of proteinIL-2 to trigger Stat phosphorylation was examined. |
| 1.6326 | 10.6392 | 1.0000 | Since many cytokines that activate Jak kinases also lead to the tyrosine phosphorylation and activation of members of the Stat family of proteintranscription factors , the ability of IL-2 to trigger Stat phosphorylation was examined. |
| 1.5027 | 10.8844 | 1.0000 | Since many cytokines that activate Jak kinases also lead to the tyrosine phosphorylation and activation of members of the proteinStat family of transcription factors , the ability of IL-2 to trigger Stat phosphorylation was examined. |
| 1.5027 | 10.7663 | 1.0000 | Since many cytokines that activate proteinJak kinases also lead to the tyrosine phosphorylation and activation of members of the Stat family of transcription factors , the ability of IL-2 to trigger Stat phosphorylation was examined. |
| 0.8466 | 1.0000 | 1.0000 | Since many cytokines that activate Jak kinases also lead to the tyrosine phosphorylation and activation of members of the Stat family of transcription factors , the ability of IL-2 to trigger proteinStat phosphorylation was examined. |
| Since many cytokines that activate Jak proteinkinases also lead to the tyrosine phosphorylation and activation of members of the Stat family of transcription factors , the ability of IL-2 to trigger Stat phosphorylation was examined. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.3445 | 30.0240 | 10.6188 | Exposure of activated human T lymphocytes or of a cell_linenatural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and Stat3 , as well as of two Stat-related proteins , p94 and p95 . |
| 1.9757 | 20.7547 | 1.0000 | Exposure of activated human T lymphocytes or of a natural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and Stat3 , as well as of two proteinStat-related proteins , p94 and p95 . |
| 1.5923 | 10.3906 | 1.0000 | Exposure of activated human T lymphocytes or of a natural killer cell line ( NKL ) to proteinIL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and Stat3 , as well as of two Stat-related proteins , p94 and p95 . |
| 1.5379 | 10.4331 | 1.0000 | Exposure of activated human T lymphocytes or of a natural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , proteinStat1 beta , and Stat3 , as well as of two Stat-related proteins , p94 and p95 . |
| 1.5268 | 10.6316 | 1.0000 | Exposure of activated human T lymphocytes or of a natural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and proteinStat3 , as well as of two Stat-related proteins , p94 and p95 . |
| 1.4148 | 10.8179 | 1.0000 | Exposure of activated human T lymphocytes or of a natural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of proteinStat1 alpha , Stat1 beta , and Stat3 , as well as of two Stat-related proteins , p94 and p95 . |
| 0.9194 | 1.0000 | 1.0000 | Exposure of activated human T lymphocytes or of a natural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and Stat3 , as well as of two Stat-related proteins , p94 and proteinp95 . |
| 0.9092 | 1.0000 | 1.0000 | Exposure of activated human T lymphocytes or of a natural killer cell line ( cell_lineNKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and Stat3 , as well as of two Stat-related proteins , p94 and p95 . |
| 0.8875 | 1.0000 | 1.0000 | Exposure of activated human T lymphocytes or of a natural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and Stat3 , as well as of two Stat-related proteins , proteinp94 and p95 . |
| 3.3725 | 20.9462 | 20.1974 | Exposure of cell_typeactivated human T lymphocytes or of a natural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and Stat3 , as well as of two Stat-related proteins , p94 and p95 . |
| Exposure of activated human cell_typeT lymphocytes or of a natural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and Stat3 , as well as of two Stat-related proteins , p94 and p95 . | |||
| Exposure of activated human T lymphocytes or of a cell_typenatural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and Stat3 , as well as of two Stat-related proteins , p94 and p95 . | |||
| Exposure of activated cell_typehuman T lymphocytes or of a natural killer cell line ( NKL ) to IL-2 leads to the phosphorylation of Stat1 alpha , Stat1 beta , and Stat3 , as well as of two Stat-related proteins , p94 and p95 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5501 | 20.5786 | 10.4972 | p94 and p95 share homology with Stat1 at the phosphorylation site and in the proteinSrc homology 2 (SH2) domain , but otherwise are immunologically distinct from Stat1 . |
| 1.3917 | 10.1005 | 1.0000 | p94 and p95 share homology with proteinStat1 at the phosphorylation site and in the Src homology 2 (SH2) domain , but otherwise are immunologically distinct from Stat1 . |
| 1.2193 | 10.7454 | 1.0000 | p94 and p95 share homology with Stat1 at the phosphorylation site and in the Src homology 2 (SH2) domain , but otherwise are immunologically distinct from proteinStat1 . |
| 1.1741 | 10.5286 | 0.9999 | p94 and p95 share homology with Stat1 at the proteinphosphorylation site and in the Src homology 2 (SH2) domain , but otherwise are immunologically distinct from Stat1 . |
| 0.9726 | 1.0000 | 1.0000 | proteinp94 and p95 share homology with Stat1 at the phosphorylation site and in the Src homology 2 (SH2) domain , but otherwise are immunologically distinct from Stat1 . |
| 0.9362 | 1.0000 | 1.0000 | p94 and proteinp95 share homology with Stat1 at the phosphorylation site and in the Src homology 2 (SH2) domain , but otherwise are immunologically distinct from Stat1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5570 | 10.9587 | 1.0000 | These proteinStat proteins were found to translocate to the nucleus and to bind to a specific DNA sequence . |
| 2.2720 | 20.4026 | 0.9999 | These Stat proteins were found to translocate to the nucleus and to bind to a specific DNADNA sequence . |
| These Stat proteins were found to translocate to the nucleus and to bind to a DNAspecific DNA sequence . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6774 | 10.1904 | 1.0000 | These findings suggest a mechanism by which proteinIL-2 binding to its receptor may activate specific genes involved in immune cell function . |
| 1.3904 | 10.9604 | 0.9997 | These findings suggest a mechanism by which IL-2 binding to its receptor may activate specific genes involved in cell_typeimmune cell function . |
| 0.5404 | 0.9998 | 1.0000 | These findings suggest a mechanism by which IL-2 binding to its receptor may activate specific DNAgenes involved in immune cell function . |
| These findings suggest a mechanism by which IL-2 binding to its receptor may activate DNAspecific genes involved in immune cell function . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5399 | 10.8713 | 1.0000 | Expression of DNAc-fos correlates with IFN-alpha responsiveness in Philadelphia chromosome positive chronic myelogenous leukemia . |
| 0.8690 | 1.0000 | 1.0000 | Expression of c-fos correlates with proteinIFN-alpha responsiveness in Philadelphia chromosome positive chronic myelogenous leukemia . |
| 1.4856 | 10.7718 | 1.0000 | Expression of c-fos correlates with IFN-alpha responsiveness in DNAPhiladelphia chromosome positive chronic myelogenous leukemia . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4931 | 20.0474 | 1.0000 | This study evaluates (i) constitutive levels of oncogene and p53 transcripts in chronic phase CML patients and (ii) their modulations subsequent to in vivo therapy with proteinrIFN-alpha 2c . |
| This study evaluates (i) constitutive levels of DNAoncogene and p53 transcripts in chronic phase CML patients and (ii) their modulations subsequent to in vivo therapy with rIFN-alpha 2c . | |||
| This study evaluates (i) constitutive levels of oncogene and RNAp53 transcripts in chronic phase CML patients and (ii) their modulations subsequent to in vivo therapy with rIFN-alpha 2c . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2715 | 20.4998 | 10.6374 | Peripheral blood mononuclear cells ( pbmc ) and cell_typebone marrow cells of 26 patients were examined for c-fos , c-myc , p53 and the hybrid bcr/abl mRNA levels . |
| 1.6735 | 0.9972 | 10.3488 | cell_typePeripheral blood mononuclear cells ( pbmc ) and bone marrow cells of 26 patients were examined for c-fos , c-myc , p53 and the hybrid bcr/abl mRNA levels . |
| 0.9077 | 0.9999 | 1.0000 | Peripheral blood mononuclear cells ( cell_typepbmc ) and bone marrow cells of 26 patients were examined for c-fos , c-myc , p53 and the hybrid bcr/abl mRNA levels . |
| 3.1679 | 20.8413 | 10.9338 | Peripheral blood mononuclear cells ( pbmc ) and bone marrow cells of 26 patients were examined for c-fos , c-myc , p53 and the RNAhybrid bcr/abl mRNA levels . |
| 0.6995 | 1.0000 | 1.0000 | Peripheral blood mononuclear cells ( pbmc ) and bone marrow cells of 26 patients were examined for c-fos , DNAc-myc , p53 and the hybrid bcr/abl mRNA levels . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4501 | 20.9881 | 1.0000 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the DNAhybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . |
| 2.4369 | 20.7795 | 0.9999 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of cell_typeimmature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . |
| 1.8167 | 10.0715 | 1.0000 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to proteinIFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . |
| 1.8146 | 10.1556 | 1.0000 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to proteinIFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . |
| 1.7375 | 10.4942 | 1.0000 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of cell_typelymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . |
| 1.0066 | 10.1281 | 0.9997 | Results indicated that (i) constitutive RNAc-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . |
| 0.8699 | 0.9982 | 0.9999 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of RNAc-myc mRNA levels in responder patients . |
| 0.8363 | 1.0000 | 0.9999 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the cell_typepbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . |
| 1.4698 | 10.7811 | 1.0000 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of proteinc-fos and downregulation of c-myc mRNA levels in responder patients . |
| 0.9662 | 1.0000 | 1.0000 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and proteinp53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . |
| 0.8009 | 1.0000 | 1.0000 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , proteinc-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . |
| 0.7840 | 0.9999 | 0.9993 | Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive RNAmRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . |
| Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) RNAconstitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . | |||
| Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of DNAc-fos and downregulation of c-myc mRNA levels in responder patients . | |||
| Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , c-myc and DNAp53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . | |||
| Results indicated that (i) constitutive c-fos transcript levels are significantly higher in patients subsequently responding to IFN-alpha therapy (p < 0.01) and positively correlated with the proportion of lymphocytes (r = 0.6895, p < 0.01) and negatively with the proportion of immature cells (r = -0.568, p < 0.01) contained in the pbmc preparations tested, (ii) constitutive mRNA levels of the hybrid bcr/abl , DNAc-myc and p53 are positively correlated with each other, but failed to relate to disease parameters, and (iii) acute and chronic in vivo exposure to IFN-alpha is accompanied by upregulation of c-fos and downregulation of c-myc mRNA levels in responder patients . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0363 | 20.4575 | 10.4843 | Menopause is associated with a significant increase in blood monocyte number and a relative decrease in the expression of estrogen receptors in cell_typehuman peripheral monocytes . |
| 2.1837 | 20.7536 | 0.9999 | Menopause is associated with a significant increase in blood monocyte number and a relative decrease in the expression of proteinestrogen receptors in human peripheral monocytes . |
| 2.2578 | 20.1298 | 0.9999 | Menopause is associated with a significant increase in cell_typeblood monocyte number and a relative decrease in the expression of estrogen receptors in human peripheral monocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2070 | 20.7427 | 1.0000 | PROBLEM: The clinical significance of the differential expression of proteinestrogen receptor ( ER ) in human monocytes was evaluated. |
| 1.5096 | 10.5289 | 0.9999 | PROBLEM: The clinical significance of the differential expression of estrogen receptor ( ER ) in cell_typehuman monocytes was evaluated. |
| 0.9697 | 1.0000 | 1.0000 | PROBLEM: The clinical significance of the differential expression of estrogen receptor ( proteinER ) in human monocytes was evaluated. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9368 | 0.9999 | 1.0000 | In addition, the monocyte and cell_typelymphocyte counts and the blood estrogen levels of each patient were determine. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0436 | 20.5767 | 10.8115 | RESULTS: During menopause there is a significant decrease in the percentage of cell_typeER positive monocytes , and an increase in blood monocyte number , which declines following estrogen replacement therapy to values of the young. |
| 2.3522 | 20.2909 | 0.9944 | RESULTS: During menopause there is a significant decrease in the percentage of proteinER positive monocytes , and an increase in blood monocyte number , which declines following estrogen replacement therapy to values of the young. |
| 0.9099 | 1.0000 | 1.0000 | RESULTS: During menopause there is a significant decrease in the percentage of ER positive monocytes , and an increase in blood cell_typemonocyte number , which declines following estrogen replacement therapy to values of the young. |
| 0.9591 | 1.0000 | 1.0000 | RESULTS: During menopause there is a significant decrease in the percentage of ER positive cell_typemonocytes , and an increase in blood monocyte number , which declines following estrogen replacement therapy to values of the young. |
| RESULTS: During menopause there is a significant decrease in the percentage of ER positive monocytes , and an increase in cell_typeblood monocyte number , which declines following estrogen replacement therapy to values of the young. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7662 | 10.6680 | 1.0000 | CONCLUSIONS: These findings suggest that estrogen modulates the monocyte numbers and its effects may be mediated through the proteinER in the monocytes . |
| 1.7592 | 10.4221 | 1.0000 | CONCLUSIONS: These findings suggest that estrogen modulates the monocyte numbers and its effects may be mediated through the ER in the cell_typemonocytes . |
| 0.8085 | 1.0000 | 1.0000 | CONCLUSIONS: These findings suggest that estrogen modulates the cell_typemonocyte numbers and its effects may be mediated through the ER in the monocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1782 | 20.6003 | 20.9399 | Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( Jak3 ) and proteinsignal transducers and activators of transcription ( Stat proteins ). |
| 4.9497 | 30.8607 | 20.4804 | Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the proteinJanus protein- tyrosine kinase 3 ( Jak3 ) and signal transducers and activators of transcription ( Stat proteins ). |
| 2.6119 | 30.2762 | 10.0721 | Staphylococcal enterotoxins modulate proteininterleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( Jak3 ) and signal transducers and activators of transcription ( Stat proteins ). |
| 1.5352 | 10.3257 | 0.9999 | Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( Jak3 ) and signal transducers and activators of transcription ( proteinStat proteins ). |
| 0.9519 | 1.0000 | 1.0000 | Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( proteinJak3 ) and signal transducers and activators of transcription ( Stat proteins ). |
| proteinStaphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( Jak3 ) and signal transducers and activators of transcription ( Stat proteins ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7163 | 20.8270 | 10.7877 | Staphylococcal enterotoxins ( SE ) stimulate T cells expressing the appropriate proteinvariable region beta chain of ( V beta ) T-cell receptors and have been implicated in the pathogenesis of several autoimmune diseases . |
| 1.4735 | 10.6485 | 0.9998 | Staphylococcal enterotoxins ( SE ) stimulate cell_typeT cells expressing the appropriate variable region beta chain of ( V beta ) T-cell receptors and have been implicated in the pathogenesis of several autoimmune diseases . |
| 0.9298 | 1.0000 | 1.0000 | Staphylococcal enterotoxins ( proteinSE ) stimulate T cells expressing the appropriate variable region beta chain of ( V beta ) T-cell receptors and have been implicated in the pathogenesis of several autoimmune diseases . |
| 0.7028 | 0.9972 | 0.9999 | proteinStaphylococcal enterotoxins ( SE ) stimulate T cells expressing the appropriate variable region beta chain of ( V beta ) T-cell receptors and have been implicated in the pathogenesis of several autoimmune diseases . |
| 4.7973 | 20.1031 | 20.4115 | Staphylococcal enterotoxins ( SE ) stimulate T cells expressing the appropriate variable region beta chain of protein( V beta ) T-cell receptors and have been implicated in the pathogenesis of several autoimmune diseases . |
| 1.5070 | 0.9998 | 10.9399 | Staphylococcal enterotoxins ( SE ) stimulate T cells expressing the appropriate variable region beta chain of ( proteinV beta ) T-cell receptors and have been implicated in the pathogenesis of several autoimmune diseases . |
| Staphylococcal enterotoxins ( SE ) stimulate T cells expressing the appropriate variable region beta chain of ( proteinV beta ) T-cell receptors and have been implicated in the pathogenesis of several autoimmune diseases . | |||
| Staphylococcal enterotoxins ( SE ) stimulate T cells expressing the appropriate proteinvariable region beta chain of ( V beta ) T-cell receptors and have been implicated in the pathogenesis of several autoimmune diseases . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3074 | 20.3903 | 0.9998 | Depending on costimulatory signals , SE induce either proliferation or anergy in cell_typeT cells . |
| 1.0448 | 10.0052 | 1.0000 | Depending on costimulatory signals , proteinSE induce either proliferation or anergy in T cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9833 | 1.0000 | 1.0000 | In addition, SE can induce an interleukin-2 ( proteinIL-2 ) nonresponsive state and apoptosis . |
| 0.8437 | 1.0000 | 0.9999 | In addition, SE can induce an proteininterleukin-2 ( IL-2 ) nonresponsive state and apoptosis . |
| In addition, proteinSE can induce an interleukin-2 ( IL-2 ) nonresponsive state and apoptosis . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8611 | 20.5893 | 10.8196 | Here, we show that SE induce dynamic changes in the expression of and signal transduction through the IL-2 receptor (IL-2R) beta and gamma chains ( IL-2R beta and IL-2R gamma ) in cell_linehuman antigen-specific CD4+ T-cell lines . |
| 1.6128 | 10.3746 | 1.0000 | Here, we show that SE induce dynamic changes in the expression of and signal transduction through the IL-2 receptor (IL-2R) beta and gamma chains ( IL-2R beta and proteinIL-2R gamma ) in human antigen-specific CD4+ T-cell lines . |
| 0.8198 | 0.9997 | 1.0000 | Here, we show that SE induce dynamic changes in the expression of and signal transduction through the IL-2 receptor (IL-2R) beta and gamma chains ( proteinIL-2R beta and IL-2R gamma ) in human antigen-specific CD4+ T-cell lines . |
| 0.7890 | 1.0000 | 0.9933 | Here, we show that SE induce dynamic changes in the expression of and signal transduction through the proteinIL-2 receptor (IL-2R) beta and gamma chains ( IL-2R beta and IL-2R gamma ) in human antigen-specific CD4+ T-cell lines . |
| Here, we show that proteinSE induce dynamic changes in the expression of and signal transduction through the IL-2 receptor (IL-2R) beta and gamma chains ( IL-2R beta and IL-2R gamma ) in human antigen-specific CD4+ T-cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3683 | 20.2203 | 0.9999 | Thus, after 4 hr of exposure to SEA and SEB , the expression of IL-2R beta was down-regulated, IL-2R gamma was slightly up-regulated, while proteinIL-2R alpha remained largely unaffected. |
| 2.3365 | 20.3607 | 1.0000 | Thus, after 4 hr of exposure to SEA and SEB , the expression of proteinIL-2R beta was down-regulated, IL-2R gamma was slightly up-regulated, while IL-2R alpha remained largely unaffected. |
| 1.6895 | 10.8786 | 1.0000 | Thus, after 4 hr of exposure to SEA and SEB , the expression of IL-2R beta was down-regulated, proteinIL-2R gamma was slightly up-regulated, while IL-2R alpha remained largely unaffected. |
| 1.6668 | 10.3296 | 1.0000 | Thus, after 4 hr of exposure to proteinSEA and SEB , the expression of IL-2R beta was down-regulated, IL-2R gamma was slightly up-regulated, while IL-2R alpha remained largely unaffected. |
| 0.9430 | 1.0000 | 1.0000 | Thus, after 4 hr of exposure to SEA and proteinSEB , the expression of IL-2R beta was down-regulated, IL-2R gamma was slightly up-regulated, while IL-2R alpha remained largely unaffected. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.1453 | 30.7123 | 20.2114 | The changes in the composition of IL-2Rs were accompanied by inhibition of IL-2 -induced tyrosine phosphorylation of the proteinJanus protein- tyrosine kinase 3 ( Jak3 ) and signal transducers and activators of transcription called Stat3 and Stat5 . |
| 1.4109 | 10.7917 | 1.0000 | The changes in the composition of proteinIL-2Rs were accompanied by inhibition of IL-2 -induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( Jak3 ) and signal transducers and activators of transcription called Stat3 and Stat5 . |
| 0.9689 | 1.0000 | 1.0000 | The changes in the composition of IL-2Rs were accompanied by inhibition of IL-2 -induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( proteinJak3 ) and signal transducers and activators of transcription called Stat3 and Stat5 . |
| 0.9388 | 1.0000 | 1.0000 | The changes in the composition of IL-2Rs were accompanied by inhibition of IL-2 -induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( Jak3 ) and signal transducers and activators of transcription called proteinStat3 and Stat5 . |
| 0.9376 | 1.0000 | 1.0000 | The changes in the composition of IL-2Rs were accompanied by inhibition of IL-2 -induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( Jak3 ) and signal transducers and activators of transcription called Stat3 and proteinStat5 . |
| 0.9082 | 1.0000 | 1.0000 | The changes in the composition of IL-2Rs were accompanied by inhibition of proteinIL-2 -induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( Jak3 ) and signal transducers and activators of transcription called Stat3 and Stat5 . |
| 2.8950 | 10.7892 | 10.9025 | The changes in the composition of IL-2Rs were accompanied by inhibition of IL-2 -induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( Jak3 ) and signal transducers and proteinactivators of transcription called Stat3 and Stat5 . |
| The changes in the composition of IL-2Rs were accompanied by inhibition of IL-2 -induced tyrosine phosphorylation of the Janus protein- tyrosine kinase 3 ( Jak3 ) and proteinsignal transducers and activators of transcription called Stat3 and Stat5 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7171 | 10.2240 | 1.0000 | In parallel experiments, proteinIL-2 -driven proliferation was inhibited significantly. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7311 | 10.7642 | 1.0000 | After 16 hr of exposure to SE , the expression of IL-2R beta remained low, while that of IL2R alpha and proteinIL2R gamma was further up-regulated, and ligand-induced tyrosine phosphorylation of Jak3 and Stat proteins was partly normalized. |
| 1.6688 | 10.8717 | 1.0000 | After 16 hr of exposure to SE , the expression of IL-2R beta remained low, while that of IL2R alpha and IL2R gamma was further up-regulated, and ligand-induced tyrosine phosphorylation of proteinJak3 and Stat proteins was partly normalized. |
| 1.6387 | 10.9465 | 1.0000 | After 16 hr of exposure to SE , the expression of proteinIL-2R beta remained low, while that of IL2R alpha and IL2R gamma was further up-regulated, and ligand-induced tyrosine phosphorylation of Jak3 and Stat proteins was partly normalized. |
| 1.6347 | 10.7239 | 1.0000 | After 16 hr of exposure to SE , the expression of IL-2R beta remained low, while that of proteinIL2R alpha and IL2R gamma was further up-regulated, and ligand-induced tyrosine phosphorylation of Jak3 and Stat proteins was partly normalized. |
| 1.6243 | 10.5600 | 1.0000 | After 16 hr of exposure to SE , the expression of IL-2R beta remained low, while that of IL2R alpha and IL2R gamma was further up-regulated, and ligand-induced tyrosine phosphorylation of Jak3 and proteinStat proteins was partly normalized. |
| After 16 hr of exposure to proteinSE , the expression of IL-2R beta remained low, while that of IL2R alpha and IL2R gamma was further up-regulated, and ligand-induced tyrosine phosphorylation of Jak3 and Stat proteins was partly normalized. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4596 | 10.8947 | 0.9999 | Yet, IL-2 -driven proliferation remained profoundly inhibited, suggesting that signaling events other than proteinJak3 /Stat activation had also been changed following SE stimulation . |
| 0.9691 | 1.0000 | 1.0000 | Yet, IL-2 -driven proliferation remained profoundly inhibited, suggesting that signaling events other than Jak3 protein/Stat activation had also been changed following SE stimulation . |
| 0.9444 | 1.0000 | 1.0000 | Yet, proteinIL-2 -driven proliferation remained profoundly inhibited, suggesting that signaling events other than Jak3 /Stat activation had also been changed following SE stimulation . |
| Yet, IL-2 -driven proliferation remained profoundly inhibited, suggesting that signaling events other than Jak3 /Stat activation had also been changed following proteinSE stimulation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8419 | 20.2280 | 10.9325 | In conclusion, our data suggest that SE can modulate IL-2R expression and signal transduction involving the Jak/Stat pathway in cell_lineCD4+ T-cell lines . |
| 1.5753 | 10.3272 | 1.0000 | In conclusion, our data suggest that SE can modulate proteinIL-2R expression and signal transduction involving the Jak/Stat pathway in CD4+ T-cell lines . |
| 0.9345 | 1.0000 | 1.0000 | In conclusion, our data suggest that SE can modulate IL-2R expression and signal transduction involving the proteinJak/Stat pathway in CD4+ T-cell lines . |
| In conclusion, our data suggest that proteinSE can modulate IL-2R expression and signal transduction involving the Jak/Stat pathway in CD4+ T-cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8738 | 20.7564 | 10.9218 | Constitutive NF-kappa B activation , enhanced granulopoiesis , and neonatal lethality in proteinI kappa B alpha -deficient mice . |
| 1.5386 | 10.5915 | 1.0000 | Constitutive proteinNF-kappa B activation , enhanced granulopoiesis , and neonatal lethality in I kappa B alpha -deficient mice . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3136 | 20.5294 | 10.7640 | Transcription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins , mainly proteinI kappa B alpha and I kappa B beta . |
| 3.8054 | 20.9690 | 10.8749 | Transcription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins , mainly I kappa B alpha and proteinI kappa B beta . |
| 2.1015 | 20.5239 | 0.9999 | Transcription factors belonging to the proteinNF-kappa B family are controlled by inhibitory I kappa B proteins , mainly I kappa B alpha and I kappa B beta . |
| 1.4104 | 20.5931 | 0.7224 | Transcription factors belonging to the proteinNF-kappa B family are controlled by inhibitory I kappa B proteins , mainly I kappa B alpha and I kappa B beta . |
| 0.8398 | 0.9995 | 1.0000 | proteinTranscription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins , mainly I kappa B alpha and I kappa B beta . |
| 4.3887 | 20.3073 | 10.6697 | Transcription factors belonging to the NF-kappa B family are controlled by inhibitory proteinI kappa B proteins , mainly I kappa B alpha and I kappa B beta . |
| Transcription factors belonging to the NF-kappa B family are controlled by proteininhibitory I kappa B proteins , mainly I kappa B alpha and I kappa B beta . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.0493 | 20.9403 | 10.8192 | Apparently normal at birth, proteinI kappa B alpha -/- mice exhibit severe runting, skin defects , and extensive granulopoiesis postnatally, typically dying by 8 days. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8901 | 20.3707 | 10.2257 | Hematopoietic tissues from these mice display elevated levels of both proteinnuclear NF-kappa B and mRNAs of some, but not all, genes thought to be regulated by NF-kappa B . |
| 2.2953 | 20.2071 | 0.9999 | Hematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and mRNAs of some, but not all, genes thought to be regulated by proteinNF-kappa B . |
| 0.9377 | 0.9999 | 1.0000 | Hematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and RNAmRNAs of some, but not all, genes thought to be regulated by NF-kappa B . |
| 0.7616 | 0.9999 | 0.9999 | Hematopoietic tissues from these mice display elevated levels of both nuclear proteinNF-kappa B and mRNAs of some, but not all, genes thought to be regulated by NF-kappa B . |
| 0.5230 | 0.9987 | 0.9999 | cell_typeHematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and mRNAs of some, but not all, genes thought to be regulated by NF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6665 | 20.9467 | 10.5692 | NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both proteinI kappa B alpha and the p50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities . |
| 2.0276 | 20.2645 | 1.0000 | NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the proteinp50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities . |
| 1.5947 | 10.9896 | 0.9999 | NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the p50 subunit of proteinNF-kappa B show a dramatically delayed onset of abnormalities . |
| 0.9014 | 1.0000 | 1.0000 | proteinNF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the p50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities . |
| 1.6953 | 20.6325 | 0.9874 | NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the proteinp50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3062 | 20.6908 | 10.8166 | In contrast to hematopoietic cells , I kappa B alpha -/- embryonic fibroblasts show minimal constitutive NF-kappa B , as well as normal signal-dependent NF-kappa B activation that is concomitant with proteinI kappa B beta degradation . |
| 4.0919 | 20.9559 | 10.6987 | In contrast to hematopoietic cells , cell_lineI kappa B alpha -/- embryonic fibroblasts show minimal constitutive NF-kappa B , as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation . |
| 2.9005 | 10.8926 | 10.8703 | In contrast to hematopoietic cells , proteinI kappa B alpha -/- embryonic fibroblasts show minimal constitutive NF-kappa B , as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation . |
| 2.5350 | 20.6669 | 10.0491 | In contrast to cell_typehematopoietic cells , I kappa B alpha -/- embryonic fibroblasts show minimal constitutive NF-kappa B , as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation . |
| 1.3798 | 10.5288 | 1.0000 | In contrast to hematopoietic cells , I kappa B alpha -/- embryonic fibroblasts show minimal constitutive NF-kappa B , as well as normal signal-dependent proteinNF-kappa B activation that is concomitant with I kappa B beta degradation . |
| 1.2930 | 10.7157 | 0.9999 | In contrast to hematopoietic cells , I kappa B alpha -/- embryonic fibroblasts show minimal constitutive proteinNF-kappa B , as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation . |
| In contrast to hematopoietic cells , I kappa B alpha -/- embryonic fibroblasts show minimal proteinconstitutive NF-kappa B , as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1733 | 30.9660 | 10.8104 | Our results indicate that I kappa b beta, but not proteinI kappa B alpha , is required for the signal-dependent activation of NF-kappa B in fibroblasts . |
| 1.9480 | 20.8132 | 0.9999 | Our results indicate that I kappa b beta, but not I kappa B alpha , is required for the signal-dependent activation of proteinNF-kappa B in fibroblasts . |
| 1.5443 | 10.5112 | 0.9998 | Our results indicate that I kappa b beta, but not I kappa B alpha , is required for the signal-dependent activation of NF-kappa B in cell_typefibroblasts . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3026 | 10.8582 | 10.1837 | However, proteinI kappa B alpha is required for the postinduction repression of NF-kappa B in fibroblasts . |
| 1.9825 | 20.5339 | 0.9999 | However, I kappa B alpha is required for the postinduction repression of proteinNF-kappa B in fibroblasts . |
| 1.5127 | 10.4329 | 0.9999 | However, I kappa B alpha is required for the postinduction repression of NF-kappa B in cell_typefibroblasts . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6808 | 20.7285 | 10.5536 | These results define distinct roles for the two forms of proteinI kappa B and demonstrate the necessity for stringent control of NF-kappa B . |
| 2.1827 | 20.5561 | 1.0000 | These results define distinct roles for the two forms of I kappa B and demonstrate the necessity for stringent control of proteinNF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9770 | 1.0000 | 1.0000 | proteinInterleukin-7 can induce the activation of Jak 1 , Jak 3 and STAT 5 proteins in murine T cells . |
| 3.5375 | 20.9010 | 10.9154 | Interleukin-7 can induce the activation of Jak 1 , Jak 3 and STAT 5 proteins in cell_typemurine T cells . |
| Interleukin-7 can induce the activation of proteinJak 1 , Jak 3 and STAT 5 proteins in murine T cells . | |||
| Interleukin-7 can induce the activation of Jak 1 , proteinJak 3 and STAT 5 proteins in murine T cells . | |||
| Interleukin-7 can induce the activation of Jak 1 , Jak 3 and proteinSTAT 5 proteins in murine T cells . | |||
| Interleukin-7 can induce the activation of Jak 1 , Jak 3 and STAT 5 proteins in murine cell_typeT cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8541 | 20.4483 | 10.3742 | The activation of Janus protein tyrosine kinases ( Jak ) and proteinSTAT ( signal transducer and activator of transcription ) proteins has recently been linked to the signal transduction mechanism of several cytokines . |
| 2.7479 | 30.4411 | 10.1643 | The activation of proteinJanus protein tyrosine kinases ( Jak ) and STAT ( signal transducer and activator of transcription ) proteins has recently been linked to the signal transduction mechanism of several cytokines . |
| 0.9161 | 0.9999 | 1.0000 | The activation of Janus protein tyrosine kinases ( proteinJak ) and STAT ( signal transducer and activator of transcription ) proteins has recently been linked to the signal transduction mechanism of several cytokines . |
| 0.7893 | 0.9999 | 1.0000 | The activation of Janus protein tyrosine kinases ( Jak ) and STAT ( signal transducer and activator of transcription ) proteins has recently been linked to the signal transduction mechanism of several proteincytokines . |
| 0.5017 | 1.0000 | 0.9960 | The activation of Janus protein tyrosine kinases ( Jak ) and proteinSTAT ( signal transducer and activator of transcription ) proteins has recently been linked to the signal transduction mechanism of several cytokines . |
| The activation of Janus protein tyrosine kinases ( Jak ) and STAT ( proteinsignal transducer and activator of transcription ) proteins has recently been linked to the signal transduction mechanism of several cytokines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1817 | 20.2337 | 1.0000 | IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of proteinJak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins . |
| 1.5105 | 10.9023 | 0.9999 | IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and proteinJak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins . |
| 0.9683 | 1.0000 | 1.0000 | proteinIL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins . |
| 0.7163 | 0.9999 | 0.9998 | IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple proteinSTAT proteins . |
| 3.8024 | 20.6461 | 10.6562 | IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of proteinmultiple STAT proteins . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8698 | 20.7730 | 10.6754 | The STAT proteins utilized by IL-7 were identical to those induced by IL-2 and could be identified as various proteinSTAT 5 isoforms . |
| 1.4987 | 10.8715 | 1.0000 | The STAT proteins utilized by proteinIL-7 were identical to those induced by IL-2 and could be identified as various STAT 5 isoforms . |
| 1.4605 | 10.6018 | 1.0000 | The STAT proteins utilized by IL-7 were identical to those induced by proteinIL-2 and could be identified as various STAT 5 isoforms . |
| 1.4423 | 10.8368 | 1.0000 | The proteinSTAT proteins utilized by IL-7 were identical to those induced by IL-2 and could be identified as various STAT 5 isoforms . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8137 | 10.2053 | 1.0000 | Moreover, the induction of both Jak 1 and 3 , and STAT 5 activity strongly correlated with the growth-promoting effects of IL-7 , suggesting that this signal transduction mechanism may play a key role in proteinIL-7 -induced proliferation . |
| 1.7645 | 10.3036 | 1.0000 | Moreover, the induction of both Jak 1 and 3 , and STAT 5 activity strongly correlated with the growth-promoting effects of proteinIL-7 , suggesting that this signal transduction mechanism may play a key role in IL-7 -induced proliferation . |
| 1.6907 | 10.8470 | 1.0000 | Moreover, the induction of both Jak 1 and 3 , and proteinSTAT 5 activity strongly correlated with the growth-promoting effects of IL-7 , suggesting that this signal transduction mechanism may play a key role in IL-7 -induced proliferation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9838 | 1.0000 | 1.0000 | proteinCytokine -modulating activity of tepoxalin , a new potential antirheumatic . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9126 | 1.0000 | 1.0000 | Tepoxalin is a new dual proteincyclooxygenase/5-lipoxygenase anti-inflammatory compound currently under clinical investigation. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7871 | 10.2958 | 1.0000 | It has been shown to possess anti-inflammatory activity in a variety of animal models and more recently to inhibit proteinIL-2 induced signal transduction . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9435 | 1.0000 | 1.0000 | The current study was conducted to evaluate the proteincytokine modulating activity of tepoxalin and the role of iron in these effects. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1022 | 10.7704 | 20.7681 | In cell_typehuman peripheral blood mononuclear cells ( PBMC ) stimulated with OKT3/PMA , tepoxalin inhibited lymphocyte proliferation with an IC50 of 6 microM. |
| 0.9208 | 1.0000 | 1.0000 | In human peripheral blood mononuclear cells ( cell_typePBMC ) stimulated with OKT3/PMA , tepoxalin inhibited lymphocyte proliferation with an IC50 of 6 microM. |
| 0.5240 | 0.9997 | 1.0000 | In human peripheral blood mononuclear cells ( PBMC ) stimulated with proteinOKT3/PMA , tepoxalin inhibited lymphocyte proliferation with an IC50 of 6 microM. |
| In human peripheral blood mononuclear cells ( PBMC ) stimulated with OKT3/PMA , tepoxalin inhibited cell_typelymphocyte proliferation with an IC50 of 6 microM. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6220 | 10.6248 | 1.0000 | Additionally, it inhibited the production of LTB4 (IC50 = 0.5 microM) and the proteincytokines IL-2 , IL-6 and TNF alpha (IC50 = 10-12 microM). |
| 0.9786 | 1.0000 | 1.0000 | Additionally, it inhibited the production of LTB4 (IC50 = 0.5 microM) and the cytokines IL-2 , proteinIL-6 and TNF alpha (IC50 = 10-12 microM). |
| 0.9559 | 1.0000 | 1.0000 | Additionally, it inhibited the production of LTB4 (IC50 = 0.5 microM) and the cytokines proteinIL-2 , IL-6 and TNF alpha (IC50 = 10-12 microM). |
| 0.8320 | 0.9998 | 1.0000 | Additionally, it inhibited the production of LTB4 (IC50 = 0.5 microM) and the cytokines IL-2 , IL-6 and proteinTNF alpha (IC50 = 10-12 microM). |
| Additionally, it inhibited the production of proteinLTB4 (IC50 = 0.5 microM) and the cytokines IL-2 , IL-6 and TNF alpha (IC50 = 10-12 microM). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6536 | 10.7604 | 1.0000 | Add-back experiments with either proteincytokines ( IL-2 or IL-6 ), LTB4 or conditioned media failed to restore the proliferative response in the presence of tepoxalin . |
| 0.9633 | 1.0000 | 1.0000 | Add-back experiments with either cytokines ( IL-2 or proteinIL-6 ), LTB4 or conditioned media failed to restore the proliferative response in the presence of tepoxalin . |
| 0.9316 | 1.0000 | 1.0000 | Add-back experiments with either cytokines ( proteinIL-2 or IL-6 ), LTB4 or conditioned media failed to restore the proliferative response in the presence of tepoxalin . |
| Add-back experiments with either cytokines ( IL-2 or IL-6 ), proteinLTB4 or conditioned media failed to restore the proliferative response in the presence of tepoxalin . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5888 | 20.6696 | 10.4157 | Tepoxalin also inhibits the activation of proteinNF kappa B , a transcription factor which acts on several cytokine genes . |
| 2.1184 | 20.7838 | 0.9998 | Tepoxalin also inhibits the activation of NF kappa B , a transcription factor which acts on several DNAcytokine genes . |
| 2.0522 | 20.1083 | 0.9999 | Tepoxalin also inhibits the activation of NF kappa B , a proteintranscription factor which acts on several cytokine genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7280 | 20.7782 | 10.4479 | Tepoxalin 's effect on proteinNF kappa B is also reversed by the addition of iron salts . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0434 | 20.5083 | 10.2557 | These data suggest that the action of tepoxalin to inhibit proliferation in PBMC may be at least in part due to its ability to reduce the amount of available iron resulting in decreased activation of proteinNF kappa B and subsequent inhibition of cytokine production . |
| 1.6961 | 10.7895 | 1.0000 | These data suggest that the action of tepoxalin to inhibit proliferation in cell_typePBMC may be at least in part due to its ability to reduce the amount of available iron resulting in decreased activation of NF kappa B and subsequent inhibition of cytokine production . |
| 0.8942 | 1.0000 | 1.0000 | These data suggest that the action of tepoxalin to inhibit proliferation in PBMC may be at least in part due to its ability to reduce the amount of available iron resulting in decreased activation of NF kappa B and subsequent inhibition of proteincytokine production . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2914 | 20.9623 | 20.5715 | N- and C-terminal sequences control degradation of proteinMAD3/ I kappa B alpha in response to inducers of NF-kappa B activity . |
| 2.1417 | 20.7427 | 1.0000 | N- and C-terminal sequences control degradation of MAD3/ I kappa B alpha in response to inducers of proteinNF-kappa B activity . |
| 1.3060 | 0.9998 | 10.9548 | N- and C-terminal sequences control degradation of MAD3/ proteinI kappa B alpha in response to inducers of NF-kappa B activity . |
| proteinN- and C-terminal sequences control degradation of MAD3/ I kappa B alpha in response to inducers of NF-kappa B activity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0014 | 20.4191 | 0.9995 | The proteolytic degradation of the inhibitory protein MAD3/ I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the proteintranscription factor NF-kappa B . |
| 1.9950 | 20.3994 | 0.9991 | The proteolytic degradation of the proteininhibitory protein MAD3/ I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B . |
| 1.6802 | 0.8434 | 10.2748 | The proteolytic degradation of the inhibitory protein proteinMAD3/ I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B . |
| 1.3935 | 0.9998 | 10.7389 | The proteolytic degradation of the inhibitory protein MAD3/ proteinI kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor NF-kappa B . |
| 0.8741 | 0.9989 | 0.9997 | The proteolytic degradation of the inhibitory protein MAD3/ I kappa B alpha in response to extracellular stimulation is a prerequisite step in the activation of the transcription factor proteinNF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1970 | 30.9829 | 20.5808 | Analysis of the expression of proteinhuman I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity , such as phorbol myristate acetate or lipopolysaccharide . |
| 3.8131 | 20.2356 | 10.8306 | Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous proteinI kappa B alpha is degraded in response to inducers of NF-kappa B activity , such as phorbol myristate acetate or lipopolysaccharide . |
| 2.9255 | 10.5340 | 10.9191 | Analysis of the expression of human I kappa B alpha protein in stable transfectants of cell_linemouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity , such as phorbol myristate acetate or lipopolysaccharide . |
| 1.9989 | 20.5708 | 0.9999 | Analysis of the expression of human I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of proteinNF-kappa B activity , such as phorbol myristate acetate or lipopolysaccharide . |
| 0.6024 | 1.0000 | 0.6402 | Analysis of the expression of human proteinI kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity , such as phorbol myristate acetate or lipopolysaccharide . |
| 1.4935 | 30.9601 | 10.6238 | Analysis of the expression of proteinhuman I kappa B alpha protein in stable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity , such as phorbol myristate acetate or lipopolysaccharide . |
| 1.4288 | 10.4746 | 0.9996 | Analysis of the expression of human I kappa B alpha protein in cell_linestable transfectants of mouse 70Z/3 cells shows that, as for the endogenous murine protein, exogenous I kappa B alpha is degraded in response to inducers of NF-kappa B activity , such as phorbol myristate acetate or lipopolysaccharide . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.5155 | 30.9878 | 20.2158 | In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the proteinhuman I kappa B alpha protein . |
| 0.8142 | 1.0000 | 1.0000 | In addition, pretreatment of the cells with the proteinproteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human I kappa B alpha protein . |
| 0.6560 | 1.0000 | 0.5441 | In addition, pretreatment of the cells with the proteasome inhibitor N-Ac-Leu-Leu-norleucinal inhibits this ligand-induced degradation and, in agreement with previous studies, stabilizes a hyperphosphorylated form of the human proteinI kappa B alpha protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1893 | 30.3899 | 0.9998 | By expressing mutant forms of the human protein in this cell line , we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of proteinI kappa B alpha . |
| 2.2775 | 20.0646 | 0.9999 | By expressing mutant forms of the human protein in this cell_linecell line , we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha . |
| 2.2367 | 20.2490 | 1.0000 | By expressing mutant forms of the proteinhuman protein in this cell line , we have been able to delineate the sequences responsible for both the ligand-induced phosphorylation and the degradation of I kappa B alpha . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4521 | 20.2148 | 10.9325 | Our results show that deletion of the C terminus of the I kappa B alpha molecule up to proteinamino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation . |
| 2.4159 | 20.2680 | 10.8963 | Our results show that deletion of the C terminus of the proteinI kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation . |
| 1.3114 | 10.8500 | 0.9999 | Our results show that deletion of the proteinC terminus of the I kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation . |
| 3.9193 | 20.2093 | 10.0654 | Our results show that deletion of the C terminus of the proteinI kappa B alpha molecule up to amino acid 279 abolishes constitutive but not ligand-inducible phosphorylation and inhibits ligand-inducible degradation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1751 | 20.4183 | 10.7386 | Further analysis reveals that the inducible phosphorylation of proteinI kappa B alpha maps to two serines in the N terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. |
| 1.5955 | 10.9424 | 1.0000 | Further analysis reveals that the inducible phosphorylation of I kappa B alpha maps to two serines in the proteinN terminus of the protein (residues 32 and 36) and that the mutation of either residue is sufficient to abolish ligand-induced degradation, whereas both residues must be mutated to abolish inducible phosphorylation of the protein. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8426 | 1.0000 | 1.0000 | proteinMicrotubules mediate cellular 25-hydroxyvitamin D3 trafficking and the genomic response to 1,25-dihydroxyvitamin D3 in normal human monocytes . |
| 3.6056 | 20.6897 | 10.7594 | Microtubules mediate cellular 25-hydroxyvitamin D3 trafficking and the genomic response to 1,25-dihydroxyvitamin D3 in cell_typenormal human monocytes . |
| Microtubules mediate cellular 25-hydroxyvitamin D3 trafficking and the genomic response to 1,25-dihydroxyvitamin D3 in normal cell_typehuman monocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3065 | 0.9999 | 10.7024 | The genomic actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the intracellular proteinvitamin D receptor ( VDR ). |
| 0.9621 | 1.0000 | 1.0000 | The genomic actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the intracellular vitamin D receptor ( proteinVDR ). |
| 3.7116 | 20.4407 | 10.9068 | The genomic actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the proteinintracellular vitamin D receptor ( VDR ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4847 | 20.8683 | 0.9999 | Although immunocytochemistry has shown that disruption of microtubular assembly prevents nuclear access of the proteinsterol- VDR complex , the role of microtubules in the response to 1,25(OH)2D3 has not been studied in viable cells . |
| 2.3944 | 20.3647 | 0.9998 | Although immunocytochemistry has shown that disruption of microtubular assembly prevents nuclear access of the sterol- VDR complex , the role of microtubules in the response to 1,25(OH)2D3 has not been studied in cell_typeviable cells . |
| 1.6942 | 10.5614 | 1.0000 | Although immunocytochemistry has shown that disruption of microtubular assembly prevents nuclear access of the sterol- VDR complex , the role of proteinmicrotubules in the response to 1,25(OH)2D3 has not been studied in viable cells . |
| 0.9467 | 1.0000 | 0.9873 | Although immunocytochemistry has shown that disruption of microtubular assembly prevents nuclear access of the sterol- proteinVDR complex , the role of microtubules in the response to 1,25(OH)2D3 has not been studied in viable cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4777 | 20.0822 | 10.6925 | Our studies examined this interaction in cell_typenormal human monocytes . |
| Our studies examined this interaction in normal cell_typehuman monocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9096 | 1.0000 | 1.0000 | cell_typeMonocytes convert 25(OH)D3 to 1,25(OH)2D3 and to 24-hydroxylated metabolites more polar than 1,25(OH)2D3 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7109 | 10.9237 | 1.0000 | Microtubule disruption totally abolished the ability of exogenous 1,25(OH)2D3 to suppress its own synthesis and to induce RNA24-hydroxylase mRNA and activity, without affecting either total 1,25(OH)2D3 uptake or maximal 1,25(OH)2D3 -VDR binding . |
| 0.9385 | 1.0000 | 1.0000 | Microtubule disruption totally abolished the ability of exogenous 1,25(OH)2D3 to suppress its own synthesis and to induce 24-hydroxylase mRNA and activity, without affecting either total 1,25(OH)2D3 uptake or maximal 1,25(OH)2D3 protein-VDR binding . |
| 1.5299 | 10.9936 | 0.9960 | Microtubule disruption totally abolished the ability of exogenous 1,25(OH)2D3 to suppress its own synthesis and to induce protein24-hydroxylase mRNA and activity, without affecting either total 1,25(OH)2D3 uptake or maximal 1,25(OH)2D3 -VDR binding . |
| 0.9666 | 1.0000 | 1.0000 | proteinMicrotubule disruption totally abolished the ability of exogenous 1,25(OH)2D3 to suppress its own synthesis and to induce 24-hydroxylase mRNA and activity, without affecting either total 1,25(OH)2D3 uptake or maximal 1,25(OH)2D3 -VDR binding . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7558 | 10.5349 | 1.0000 | Thus, intact proteinmicrotubules are essential for 1,25(OH)2D3 -dependent modulation of gene transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1568 | 20.6865 | 10.9851 | Interestingly, microtubule disruption also decreased monocyte 1,25(OH)2D3 synthesis , not by decreasing the Vmax of proteinmonocyte mitochondrial 1 alpha-hydroxylase but through an increase in the Km for 25(OH)2D3 . |
| 0.9147 | 1.0000 | 1.0000 | Interestingly, proteinmicrotubule disruption also decreased monocyte 1,25(OH)2D3 synthesis , not by decreasing the Vmax of monocyte mitochondrial 1 alpha-hydroxylase but through an increase in the Km for 25(OH)2D3 . |
| Interestingly, microtubule disruption also decreased cell_typemonocyte 1,25(OH)2D3 synthesis , not by decreasing the Vmax of monocyte mitochondrial 1 alpha-hydroxylase but through an increase in the Km for 25(OH)2D3 . | |||
| Interestingly, microtubule disruption also decreased monocyte 1,25(OH)2D3 synthesis , not by decreasing the Vmax of cell_typemonocyte mitochondrial 1 alpha-hydroxylase but through an increase in the Km for 25(OH)2D3 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9788 | 1.0000 | 1.0000 | proteinMicrotubule disruption did not affect total cellular 25(OH)D3 uptake but reduced its intracellular trafficking to the mitochondria . |
| 0.8068 | 1.0000 | 1.0000 | Microtubule disruption did not affect total cellular 25(OH)D3 uptake but reduced its intracellular trafficking to the cell_typemitochondria . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9330 | 1.0000 | 1.0000 | Thus, proteinmicrotubules participate in intracellular 25(OH)D3 transport , and their integrity determines normal 1,25(OH)2D3 synthesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6588 | 10.4889 | 1.0000 | Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in cell_typeplatelets : a new approach. |
| 1.3920 | 10.6321 | 1.0000 | Relationship between proteinRap1 protein phosphorylation and regulation of Ca2+ transport in platelets : a new approach. |
| 1.7349 | 20.0048 | 0.9859 | Relationship between proteinRap1 protein phosphorylation and regulation of Ca2+ transport in platelets : a new approach. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8894 | 10.1389 | 1.0000 | Although the interrelationship between the two messengers Ca2+ and cyclic AMP in cell_typeplatelet function is well documented, its mechanism of action still remains to be established. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3706 | 20.6147 | 1.0000 | We investigated here the question of the regulation of proteinplatelet Ca(2+)-ATPases by cyclic AMP through the phosphorylation of the Rap1 protein using a pathological model . |
| 2.1383 | 20.8120 | 1.0000 | We investigated here the question of the regulation of platelet Ca(2+)-ATPases by cyclic AMP through the phosphorylation of the proteinRap1 protein using a pathological model . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1997 | 20.5441 | 1.0000 | We first found experimental conditions where Ca(2+)-transport by platelet membrane vesicles appeared to be dependent on the phosphorylation of the proteinRap1 protein . |
| 2.8041 | 20.9167 | 10.7596 | We first found experimental conditions where Ca(2+)-transport by cell_typeplatelet membrane vesicles appeared to be dependent on the phosphorylation of the Rap1 protein . |
| 1.8249 | 20.8977 | 0.9748 | We first found experimental conditions where Ca(2+)-transport by platelet membrane vesicles appeared to be dependent on the phosphorylation of the proteinRap1 protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.2011 | 30.2549 | 10.7981 | Then, we studied platelets of patients with congestive heart failure for their expression of the potential 97 kDa Ca(2+)-ATPase target of regulation through the Rap1 protein as well as the phosphorylation of the Rap1 protein using the catalytic subunit of the proteincyclic AMP -dependent protein kinase ( C. Sub. ). |
| 4.7502 | 30.2965 | 10.8125 | Then, we studied platelets of patients with congestive heart failure for their expression of the potential protein97 kDa Ca(2+)-ATPase target of regulation through the Rap1 protein as well as the phosphorylation of the Rap1 protein using the catalytic subunit of the cyclic AMP -dependent protein kinase ( C. Sub. ). |
| 1.9901 | 20.4563 | 1.0000 | Then, we studied platelets of patients with congestive heart failure for their expression of the potential 97 kDa Ca(2+)-ATPase target of regulation through the Rap1 protein as well as the phosphorylation of the proteinRap1 protein using the catalytic subunit of the cyclic AMP -dependent protein kinase ( C. Sub. ). |
| 1.9691 | 20.4964 | 1.0000 | Then, we studied platelets of patients with congestive heart failure for their expression of the potential 97 kDa Ca(2+)-ATPase target of regulation through the proteinRap1 protein as well as the phosphorylation of the Rap1 protein using the catalytic subunit of the cyclic AMP -dependent protein kinase ( C. Sub. ). |
| 1.4863 | 10.4755 | 1.0000 | Then, we studied cell_typeplatelets of patients with congestive heart failure for their expression of the potential 97 kDa Ca(2+)-ATPase target of regulation through the Rap1 protein as well as the phosphorylation of the Rap1 protein using the catalytic subunit of the cyclic AMP -dependent protein kinase ( C. Sub. ). |
| 1.3793 | 10.7582 | 1.0000 | Then, we studied platelets of patients with congestive heart failure for their expression of the potential 97 kDa Ca(2+)-ATPase target of regulation through the Rap1 protein as well as the phosphorylation of the Rap1 protein using the proteincatalytic subunit of the cyclic AMP -dependent protein kinase ( C. Sub. ). |
| 0.9112 | 1.0000 | 0.9861 | Then, we studied platelets of patients with congestive heart failure for their expression of the potential 97 kDa proteinCa(2+)-ATPase target of regulation through the Rap1 protein as well as the phosphorylation of the Rap1 protein using the catalytic subunit of the cyclic AMP -dependent protein kinase ( C. Sub. ). |
| 0.8479 | 0.9999 | 1.0000 | Then, we studied platelets of patients with congestive heart failure for their expression of the potential 97 kDa Ca(2+)-ATPase target of regulation through the Rap1 protein as well as the phosphorylation of the Rap1 protein using the catalytic subunit of the cyclic AMP -dependent protein kinase ( proteinC. Sub. ). |
| 0.6676 | 1.0000 | 0.9994 | Then, we studied platelets of patients with congestive heart failure for their expression of the potential 97 kDa Ca(2+)-ATPase target of regulation through the Rap1 protein as well as the phosphorylation of the Rap1 protein using the catalytic subunit of the cyclic AMP -dependent protein kinase ( proteinC. Sub. ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9765 | 20.8541 | 10.8914 | In the first patients studied, we found no significant modification in the expression of the 97 kDa Ca(2+)-ATPase by Western blotting using the proteinPL/IM 430 monoclonal antibody which specifically recognized this isoform. |
| 3.6689 | 20.9933 | 10.4421 | In the first patients studied, we found no significant modification in the expression of the protein97 kDa Ca(2+)-ATPase by Western blotting using the PL/IM 430 monoclonal antibody which specifically recognized this isoform. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1877 | 20.9557 | 1.0000 | In contrast, the proteinRap1 protein was differentially phosphorylated when using 15 micrograms/ml of the C. Sub. |
| 1.6723 | 20.4825 | 0.9911 | In contrast, the Rap1 protein was differentially phosphorylated when using 15 micrograms/ml of the proteinC. Sub. |
| 1.8914 | 20.8851 | 0.9850 | In contrast, the proteinRap1 protein was differentially phosphorylated when using 15 micrograms/ml of the C. Sub. |
| 1.7728 | 20.1566 | 0.9935 | In contrast, the Rap1 protein was differentially phosphorylated when using 15 micrograms/ml of the proteinC. Sub. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3512 | 20.8414 | 1.0000 | These results allowed us to use these pathological platelets to study the relationship between the expression of proteinRap1 protein and the regulation of Ca2+ transport by selecting a patient with severe heart failure . |
| 2.4016 | 20.5501 | 0.9999 | These results allowed us to use these cell_typepathological platelets to study the relationship between the expression of Rap1 protein and the regulation of Ca2+ transport by selecting a patient with severe heart failure . |
| 2.2154 | 20.6465 | 0.9918 | These results allowed us to use these pathological platelets to study the relationship between the expression of proteinRap1 protein and the regulation of Ca2+ transport by selecting a patient with severe heart failure . |
| These results allowed us to use these pathological cell_typeplatelets to study the relationship between the expression of Rap1 protein and the regulation of Ca2+ transport by selecting a patient with severe heart failure . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4248 | 20.1884 | 1.0000 | We could show a decrease in the expression as well as in the phosphorylation of proteinRap1 protein and demonstrate a lower effect of C. Sub. on Ca2+ transport . |
| 1.6408 | 10.5014 | 1.0000 | We could show a decrease in the expression as well as in the phosphorylation of Rap1 protein and demonstrate a lower effect of proteinC. Sub. on Ca2+ transport . |
| 2.2279 | 20.5841 | 0.9918 | We could show a decrease in the expression as well as in the phosphorylation of proteinRap1 protein and demonstrate a lower effect of C. Sub. on Ca2+ transport . |
| 1.0947 | 10.8749 | 0.9892 | We could show a decrease in the expression as well as in the phosphorylation of Rap1 protein and demonstrate a lower effect of proteinC. Sub. on Ca2+ transport . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4384 | 20.1620 | 1.0000 | Finally, by studying a further series of patients , we could confirm that the decrease in Rap1 protein expression in heart failure, whatever its extent, was variable, and could strictly correlate the expression of proteinRap1 protein with the stimulatory effect of C. Sub. on Ca2+ transport . |
| 1.6909 | 10.2571 | 1.0000 | Finally, by studying a further series of patients , we could confirm that the decrease in Rap1 protein expression in heart failure, whatever its extent, was variable, and could strictly correlate the expression of Rap1 protein with the stimulatory effect of proteinC. Sub. on Ca2+ transport . |
| 1.5790 | 10.9845 | 1.0000 | Finally, by studying a further series of patients , we could confirm that the decrease in proteinRap1 protein expression in heart failure, whatever its extent, was variable, and could strictly correlate the expression of Rap1 protein with the stimulatory effect of C. Sub. on Ca2+ transport . |
| 2.4023 | 20.1193 | 0.9970 | Finally, by studying a further series of patients , we could confirm that the decrease in proteinRap1 protein expression in heart failure, whatever its extent, was variable, and could strictly correlate the expression of Rap1 protein with the stimulatory effect of C. Sub. on Ca2+ transport . |
| 2.3767 | 20.6147 | 0.9948 | Finally, by studying a further series of patients , we could confirm that the decrease in Rap1 protein expression in heart failure, whatever its extent, was variable, and could strictly correlate the expression of proteinRap1 protein with the stimulatory effect of C. Sub. on Ca2+ transport . |
| 1.1129 | 10.6462 | 0.9904 | Finally, by studying a further series of patients , we could confirm that the decrease in Rap1 protein expression in heart failure, whatever its extent, was variable, and could strictly correlate the expression of Rap1 protein with the stimulatory effect of proteinC. Sub. on Ca2+ transport . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3064 | 20.6228 | 1.0000 | Besides the evidence for regulation of the expression of the Rap1 protein in platelets from patients with heart failure , these findings constitute a new approach in favour of the regulation of platelet Ca2+ transport through the phosphorylation of the proteinRap1 protein . |
| 2.2814 | 20.7275 | 1.0000 | Besides the evidence for regulation of the expression of the proteinRap1 protein in platelets from patients with heart failure , these findings constitute a new approach in favour of the regulation of platelet Ca2+ transport through the phosphorylation of the Rap1 protein . |
| 1.8392 | 10.1807 | 1.0000 | Besides the evidence for regulation of the expression of the Rap1 protein in cell_typeplatelets from patients with heart failure , these findings constitute a new approach in favour of the regulation of platelet Ca2+ transport through the phosphorylation of the Rap1 protein . |
| 2.2197 | 20.9489 | 0.9901 | Besides the evidence for regulation of the expression of the proteinRap1 protein in platelets from patients with heart failure , these findings constitute a new approach in favour of the regulation of platelet Ca2+ transport through the phosphorylation of the Rap1 protein . |
| 2.1869 | 20.8622 | 0.9887 | Besides the evidence for regulation of the expression of the Rap1 protein in platelets from patients with heart failure , these findings constitute a new approach in favour of the regulation of platelet Ca2+ transport through the phosphorylation of the proteinRap1 protein . |
| 1.7823 | 10.3864 | 0.9999 | Besides the evidence for regulation of the expression of the Rap1 protein in platelets from patients with heart failure , these findings constitute a new approach in favour of the regulation of cell_typeplatelet Ca2+ transport through the phosphorylation of the Rap1 protein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9121 | 1.0000 | 1.0000 | An proteinIRF-1 -dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes . |
| 3.5766 | 20.2038 | 10.5814 | An IRF-1 -dependent pathway of DNA damage-induced apoptosis in cell_typemitogen-activated T lymphocytes . |
| An IRF-1 -dependent pathway of DNA damage-induced apoptosis in cell_linemitogen-activated T lymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8958 | 1.0000 | 1.0000 | cell_typeLymphocytes are particularly susceptible to DNA damage-induced apoptosis , a response which may serve as a form of ' altruistic suicide ' to counter their intrinsic high potential for mutation and clonal expansion . |
| cell_lineLymphocytes are particularly susceptible to DNA damage-induced apoptosis , a response which may serve as a form of ' altruistic suicide ' to counter their intrinsic high potential for mutation and clonal expansion . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0378 | 10.8904 | 10.1225 | The proteintumour suppressor p53 has been shown to regulate this type of apoptosis in thymocytes , but an as yet unknown, p53 -independent pathway (s) appears to mediate the same event in mitogen-activated mature T lymphocytes . |
| 1.5450 | 10.6779 | 1.0000 | The tumour suppressor p53 has been shown to regulate this type of apoptosis in cell_typethymocytes , but an as yet unknown, p53 -independent pathway (s) appears to mediate the same event in mitogen-activated mature T lymphocytes . |
| 0.8406 | 1.0000 | 1.0000 | The tumour suppressor p53 has been shown to regulate this type of apoptosis in thymocytes , but an as yet unknown, proteinp53 -independent pathway (s) appears to mediate the same event in mitogen-activated mature T lymphocytes . |
| 4.9975 | 30.6086 | 10.4708 | The tumour suppressor p53 has been shown to regulate this type of apoptosis in thymocytes , but an as yet unknown, p53 -independent pathway (s) appears to mediate the same event in cell_typemitogen-activated mature T lymphocytes . |
| 1.1170 | 0.9999 | 10.2637 | The tumour suppressor p53 has been shown to regulate this type of apoptosis in thymocytes , but an as yet unknown, p53 -independent pathway (s) appears to mediate the same event in mitogen-activated mature cell_typeT lymphocytes . |
| The tumour suppressor p53 has been shown to regulate this type of apoptosis in thymocytes , but an as yet unknown, p53 -independent pathway (s) appears to mediate the same event in cell_linemitogen-activated mature T lymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8375 | 20.7036 | 0.9997 | Here we show DNA damage-induced apoptosis in these cell_typeT lymphocytes is dependent on the antioncogenic transcription factor interferon regulatory factor (IRF)-1 . |
| 5.6664 | 30.2026 | 20.3340 | Here we show DNA damage-induced apoptosis in these T lymphocytes is dependent on the proteinantioncogenic transcription factor interferon regulatory factor (IRF)-1 . |
| 2.6348 | 20.8646 | 10.8440 | Here we show DNA damage-induced apoptosis in these T lymphocytes is dependent on the proteinantioncogenic transcription factor interferon regulatory factor (IRF)-1 . |
| Here we show DNA damage-induced apoptosis in these T lymphocytes is dependent on the antioncogenic transcription factor interferon regulatory factor protein(IRF)-1 . | |||
| Here we show DNA damage-induced apoptosis in these T lymphocytes is dependent on the proteinantioncogenic transcription factor interferon regulatory factor (IRF)-1 . | |||
| Here we show DNA damage-induced apoptosis in these T lymphocytes is dependent on the antioncogenic proteintranscription factor interferon regulatory factor (IRF)-1 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5278 | 20.9383 | 10.7902 | Thus two different proteinanti-onco-genic transcription factors , p53 and IRF-1 , are required for distinct apoptotic pathways in T lymphocytes . |
| 1.9704 | 20.9802 | 0.9998 | Thus two different anti-onco-genic transcription factors , p53 and IRF-1 , are required for distinct apoptotic pathways in cell_typeT lymphocytes . |
| 0.9390 | 1.0000 | 1.0000 | Thus two different anti-onco-genic transcription factors , proteinp53 and IRF-1 , are required for distinct apoptotic pathways in T lymphocytes . |
| 0.9219 | 1.0000 | 1.0000 | Thus two different anti-onco-genic transcription factors , p53 and proteinIRF-1 , are required for distinct apoptotic pathways in T lymphocytes . |
| 1.3411 | 1.0000 | 10.0341 | Thus two different anti-onco-genic proteintranscription factors , p53 and IRF-1 , are required for distinct apoptotic pathways in T lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.9706 | 30.2348 | 20.8455 | We also show that mitogen induction of the DNAinterleukin-1 beta converting enzyme ( ICE ) gene , a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3 , is IRF-1 -dependent . |
| 3.8968 | 40.9729 | 10.5059 | We also show that mitogen induction of the proteininterleukin-1 beta converting enzyme ( ICE ) gene , a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3 , is IRF-1 -dependent . |
| 1.2990 | 0.9987 | 20.9183 | We also show that mitogen induction of the interleukin-1 beta converting enzyme ( ICE ) gene , a mammalian homologue of the DNACaenorhabditis elegans cell death gene ced-3 , is IRF-1 -dependent . |
| 0.9282 | 0.9998 | 0.9999 | We also show that mitogen induction of the interleukin-1 beta converting enzyme ( ICE ) gene , a mammalian homologue of the Caenorhabditis elegans cell death gene DNAced-3 , is IRF-1 -dependent . |
| 0.8507 | 1.0000 | 1.0000 | We also show that mitogen induction of the interleukin-1 beta converting enzyme ( ICE ) gene , a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3 , is proteinIRF-1 -dependent . |
| 0.8039 | 1.0000 | 0.9554 | We also show that mitogen induction of the interleukin-1 beta converting enzyme ( DNAICE ) gene , a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3 , is IRF-1 -dependent . |
| We also show that mitogen induction of the interleukin-1 beta converting enzyme ( ICE ) gene , a proteinmammalian homologue of the Caenorhabditis elegans cell death gene ced-3 , is IRF-1 -dependent . | |||
| We also show that mitogen induction of the interleukin-1 beta converting enzyme ( proteinICE ) gene , a mammalian homologue of the Caenorhabditis elegans cell death gene ced-3 , is IRF-1 -dependent . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2029 | 20.2785 | 0.9999 | Ectopic overexpression of IRF-1 results in the activation of the DNAendogenous gene for ICE and enhances the sensitivity of cells to radiation-induced apoptosis . |
| 1.6320 | 10.8055 | 1.0000 | Ectopic overexpression of proteinIRF-1 results in the activation of the endogenous gene for ICE and enhances the sensitivity of cells to radiation-induced apoptosis . |
| 0.9550 | 1.0000 | 1.0000 | Ectopic overexpression of IRF-1 results in the activation of the endogenous gene for DNAICE and enhances the sensitivity of cells to radiation-induced apoptosis . |
| Ectopic overexpression of IRF-1 results in the activation of the endogenous gene for proteinICE and enhances the sensitivity of cells to radiation-induced apoptosis . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9371 | 10.8989 | 10.4352 | Circadian rhythm of glucocorticoid receptors in cell_typehuman peripheral leukocytes and their reactivity to glucocorticoids . |
| 1.9868 | 20.0590 | 0.9999 | Circadian rhythm of proteinglucocorticoid receptors in human peripheral leukocytes and their reactivity to glucocorticoids . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7571 | 10.6157 | 1.0000 | 1) There exists a CR of GR in human leukocytes , PMN , and cell_typemonocytes with the peak values from 0400 to 0800 hr and the trough values between 2300 and 0000 hr. |
| 1.5965 | 10.3608 | 0.9999 | 1) There exists a CR of GR in cell_typehuman leukocytes , PMN , and monocytes with the peak values from 0400 to 0800 hr and the trough values between 2300 and 0000 hr. |
| 0.9073 | 1.0000 | 1.0000 | 1) There exists a CR of proteinGR in human leukocytes , PMN , and monocytes with the peak values from 0400 to 0800 hr and the trough values between 2300 and 0000 hr. |
| 0.9045 | 1.0000 | 1.0000 | 1) There exists a CR of GR in human leukocytes , cell_typePMN , and monocytes with the peak values from 0400 to 0800 hr and the trough values between 2300 and 0000 hr. |
| 1.7489 | 10.3610 | 1.0000 | 1) There exists a proteinCR of GR in human leukocytes , PMN , and monocytes with the peak values from 0400 to 0800 hr and the trough values between 2300 and 0000 hr. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7555 | 10.7939 | 1.0000 | 2) The FI of the chemotactic migration rate of cell_typePMN by cortisol also showed diurnal changes which were synchronous with that of GR . |
| 1.7549 | 10.8190 | 1.0000 | 2) The FI of the chemotactic migration rate of PMN by cortisol also showed diurnal changes which were synchronous with that of proteinGR . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9074 | 1.0000 | 1.0000 | This indicates that the CR of proteinGR may be of functional significance. |
| 0.8808 | 1.0000 | 1.0000 | This indicates that the proteinCR of GR may be of functional significance. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9502 | 1.0000 | 1.0000 | 3) In Cushing's syndrome , the CR of proteinGR was normal in spite of the fact that the CR of plasma cortisol was disturbed. |
| 1.7372 | 10.5404 | 1.0000 | 3) In Cushing's syndrome , the CR of GR was normal in spite of the fact that the proteinCR of plasma cortisol was disturbed. |
| 1.6801 | 10.5958 | 1.0000 | 3) In Cushing's syndrome , the proteinCR of GR was normal in spite of the fact that the CR of plasma cortisol was disturbed. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9280 | 1.0000 | 1.0000 | This indicates the independency of the CR of proteinGR from that of cortisol . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9384 | 1.0000 | 1.0000 | 4) In apoplexy caused by brain ischemia , the CR of proteinGR was abolished in patients with basal lesions but preserved when the lesions were located in the cerebral cortex . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7569 | 10.7166 | 1.0000 | These results strongly suggest that the main " circadian pacemaker " of proteinGR is located in the basal brain , most probably in the suprachiasmatic nuclei as has been suggested for rodents . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7124 | 0.9987 | 10.7850 | cell_lineB-lymphoblastoid cell lines from multiple sclerosis patients and a healthy control producing a putative new human retrovirus and Epstein-Barr virus . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9691 | 20.5251 | 10.4698 | On several occasions we have observed retrovirus-like particles ( RVLPs ) by transmission electron microscopy ( EM ) of cell_linecultured T cells from a patient with MS . |
| 0.6407 | 1.0000 | 1.0000 | On several occasions we have observed retrovirus-like particles ( proteinRVLPs ) by transmission electron microscopy ( EM ) of cultured T cells from a patient with MS . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0582 | 20.8695 | 10.8253 | Later we established spontaneously formed cell_lineB-lymphoblastoid cell lines ( LCLs ) from a patient with an MS -like disease and from another patient with MS who had a reactivated Epstein-Barr virus (EBV) infection . |
| 0.9681 | 1.0000 | 1.0000 | Later we established spontaneously formed B-lymphoblastoid cell lines ( cell_lineLCLs ) from a patient with an MS -like disease and from another patient with MS who had a reactivated Epstein-Barr virus (EBV) infection . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9157 | 0.9999 | 1.0000 | Both cell_lineLCLs were found by EM to produce RVLP and EBV particles . |
| 1.6923 | 10.0263 | 1.0000 | Both LCLs were found by EM to produce proteinRVLP and EBV particles . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6070 | 10.5103 | 1.0000 | Reverse transcriptase (RT) assays were positive in purified viral material from both cell_lineLCLs . |
| 0.9154 | 0.9999 | 0.9996 | proteinReverse transcriptase (RT) assays were positive in purified viral material from both LCLs . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8493 | 10.7188 | 1.0000 | To substantiate these findings we initiated an intensified culturing procedure and were able to establish cell_lineLCLs from 5 out of 21 consecutive MS patients and 1 out of 13 consecutive healthy controls . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9062 | 0.9999 | 1.0000 | All cell_lineLCLs were found to produce both RVLP and EBV particles by EM . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.1292 | 30.9231 | 20.7003 | Identification of an ionomycin /cyclosporin A -responsive element within the DNAhuman T cell receptor gamma enhancer . |
| 4.5451 | 20.9656 | 20.7902 | Identification of an DNAionomycin /cyclosporin A -responsive element within the human T cell receptor gamma enhancer . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4992 | 10.9804 | 0.9998 | Activation through the Ca2+ / calcineurin pathway is essential to the transcription of many DNAcytokine genes . |
| 0.9592 | 1.0000 | 1.0000 | Activation through the Ca2+ / proteincalcineurin pathway is essential to the transcription of many cytokine genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5677 | 10.7079 | 1.0000 | The conserved cis-acting sequence , GGAAAA , and proteintranscription factors binding to this sequence are involved in the response to increased intracellular Ca2+ concentrations . |
| 2.3660 | 20.6325 | 0.9999 | The conserved DNAcis-acting sequence , GGAAAA , and transcription factors binding to this sequence are involved in the response to increased intracellular Ca2+ concentrations . |
| The DNAconserved cis-acting sequence , GGAAAA , and transcription factors binding to this sequence are involved in the response to increased intracellular Ca2+ concentrations . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.6233 | 30.6218 | 20.6667 | Here we report the identification and importance of the same sequence in a non-cytokine gene , the DNAhuman T cell receptor gamma ( TCRG ) enhancer . |
| 1.7909 | 20.5857 | 0.9994 | Here we report the identification and importance of the same sequence in a DNAnon-cytokine gene , the human T cell receptor gamma ( TCRG ) enhancer . |
| 0.8359 | 1.0000 | 0.9651 | Here we report the identification and importance of the same sequence in a non-cytokine gene , the human T cell receptor gamma ( proteinTCRG ) enhancer . |
| Here we report the identification and importance of the same sequence in a non-cytokine gene , the proteinhuman T cell receptor gamma ( TCRG ) enhancer . | |||
| Here we report the identification and importance of the same sequence in a non-cytokine gene , the cell_typehuman T cell receptor gamma ( TCRG ) enhancer . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4270 | 20.2505 | 0.9999 | Results from site-directed mutations and electrophoretic mobility shift assays strongly suggest that this sequence mediates the ionomycin -induced activation of the DNATCRG enhancer . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7885 | 10.7459 | 1.0000 | Our studies provide an explanation for a previous observation that RNATCRG mRNA levels , but not mRNA levels for T cell receptor alpha and -beta , are increased by ionomycin treatment . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9735 | 20.5005 | 0.8207 | Coexpression of proteinNF-kappa B /Rel and Sp1 transcription factors in human immunodeficiency virus 1 -induced, dendritic cell-T-cell syncytia . |
| 1.3022 | 20.8616 | 0.9996 | Coexpression of proteinNF-kappa B /Rel and Sp1 transcription factors in human immunodeficiency virus 1 -induced, dendritic cell-T-cell syncytia . |
| 0.8364 | 0.9926 | 1.0000 | Coexpression of NF-kappa B /Rel and Sp1 proteintranscription factors in human immunodeficiency virus 1 -induced, dendritic cell-T-cell syncytia . |
| 0.7886 | 0.9984 | 1.0000 | Coexpression of NF-kappa B /Rel and proteinSp1 transcription factors in human immunodeficiency virus 1 -induced, dendritic cell-T-cell syncytia . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4090 | 20.7631 | 0.9999 | Productive infection of cell_typeT cells with human immunodeficiency virus 1 ( HIV-1 ) typically requires that the T cells be stimulated with antigens or mitogens . |
| 2.4023 | 20.2945 | 0.9999 | Productive infection of T cells with human immunodeficiency virus 1 ( HIV-1 ) typically requires that the cell_typeT cells be stimulated with antigens or mitogens . |
| 0.8762 | 1.0000 | 1.0000 | Productive infection of T cells with human immunodeficiency virus 1 ( HIV-1 ) typically requires that the T cells be stimulated with proteinantigens or mitogens . |
| 0.8355 | 0.9998 | 1.0000 | Productive infection of T cells with human immunodeficiency virus 1 ( HIV-1 ) typically requires that the T cells be stimulated with antigens or proteinmitogens . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3264 | 10.9676 | 0.9998 | This requirement has been attributed to the activation of the transcription factor NF-kappa B , which synergizes with the constitutive transcription factor Sp1 to drive the DNAHIV-1 promoter . |
| 1.2859 | 10.7156 | 0.9989 | This requirement has been attributed to the activation of the proteintranscription factor NF-kappa B , which synergizes with the constitutive transcription factor Sp1 to drive the HIV-1 promoter . |
| 0.9324 | 0.9999 | 1.0000 | This requirement has been attributed to the activation of the transcription factor NF-kappa B , which synergizes with the constitutive transcription factor proteinSp1 to drive the HIV-1 promoter . |
| 0.9088 | 0.9993 | 1.0000 | This requirement has been attributed to the activation of the transcription factor proteinNF-kappa B , which synergizes with the constitutive transcription factor Sp1 to drive the HIV-1 promoter . |
| 3.7784 | 20.6583 | 10.8158 | This requirement has been attributed to the activation of the transcription factor NF-kappa B , which synergizes with the proteinconstitutive transcription factor Sp1 to drive the HIV-1 promoter . |
| This requirement has been attributed to the activation of the transcription factor NF-kappa B , which synergizes with the proteinconstitutive transcription factor Sp1 to drive the HIV-1 promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3470 | 10.8696 | 0.9998 | Recently, we have found that vigorous replication of HIV-1 takes place in nonactivated memory T cells after syncytium formation with cell_typedendritic cells ( DCs ). |
| 0.9010 | 1.0000 | 0.9999 | Recently, we have found that vigorous replication of HIV-1 takes place in nonactivated memory T cells after syncytium formation with dendritic cells ( cell_typeDCs ). |
| 4.6810 | 20.8144 | 10.7499 | Recently, we have found that vigorous replication of HIV-1 takes place in cell_typenonactivated memory T cells after syncytium formation with dendritic cells ( DCs ). |
| Recently, we have found that vigorous replication of HIV-1 takes place in nonactivated cell_typememory T cells after syncytium formation with dendritic cells ( DCs ). | |||
| Recently, we have found that vigorous replication of HIV-1 takes place in nonactivated memory cell_typeT cells after syncytium formation with dendritic cells ( DCs ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1111 | 20.0912 | 0.9997 | These syncytia lack cell_typeactivated cells as determined by an absence of staining for Ki-67 cell cycle antigen. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6560 | 10.3079 | 1.0000 | The expression and activity of NF-kappa B and proteinSp1 were, therefore, analyzed in isolated T cells and DCs from humans and mice . |
| 1.4195 | 10.8978 | 1.0000 | The expression and activity of proteinNF-kappa B and Sp1 were, therefore, analyzed in isolated T cells and DCs from humans and mice . |
| 0.8780 | 0.9999 | 0.9999 | The expression and activity of NF-kappa B and Sp1 were, therefore, analyzed in isolated T cells and cell_typeDCs from humans and mice . |
| 4.3261 | 20.3656 | 10.5863 | The expression and activity of NF-kappa B and Sp1 were, therefore, analyzed in cell_typeisolated T cells and DCs from humans and mice . |
| The expression and activity of NF-kappa B and Sp1 were, therefore, analyzed in isolated cell_typeT cells and DCs from humans and mice . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0362 | 20.1092 | 0.9999 | T cells lack active proteinNF-kappa B but express Sp1 as expected. |
| 1.3193 | 10.6755 | 1.0000 | T cells lack active NF-kappa B but express proteinSp1 as expected. |
| 0.8475 | 0.9979 | 0.9997 | cell_typeT cells lack active NF-kappa B but express Sp1 as expected. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1746 | 20.1614 | 1.0000 | DCs express high levels of all known proteinNF-kappa B and Rel proteins , with activity residing primarily within RelB , p50 , and p65 . |
| 1.5693 | 10.8203 | 1.0000 | DCs express high levels of all known NF-kappa B and Rel proteins , with activity residing primarily within RelB , p50 , and proteinp65 . |
| 1.4977 | 10.9606 | 0.9999 | DCs express high levels of all known NF-kappa B and proteinRel proteins , with activity residing primarily within RelB , p50 , and p65 . |
| 1.4619 | 10.9508 | 1.0000 | DCs express high levels of all known NF-kappa B and Rel proteins , with activity residing primarily within proteinRelB , p50 , and p65 . |
| 0.9444 | 1.0000 | 1.0000 | cell_typeDCs express high levels of all known NF-kappa B and Rel proteins , with activity residing primarily within RelB , p50 , and p65 . |
| 0.9177 | 1.0000 | 1.0000 | DCs express high levels of all known NF-kappa B and Rel proteins , with activity residing primarily within RelB , proteinp50 , and p65 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9333 | 1.0000 | 0.9999 | However, DCs lack Sp1 , which may explain the failure of HIV-1 to replicate in purified cell_typeDCs . |
| 0.8951 | 0.9998 | 1.0000 | However, cell_typeDCs lack Sp1 , which may explain the failure of HIV-1 to replicate in purified DCs . |
| 0.8436 | 0.9999 | 1.0000 | However, DCs lack proteinSp1 , which may explain the failure of HIV-1 to replicate in purified DCs . |
| 1.8851 | 20.2806 | 0.9998 | However, DCs lack Sp1 , which may explain the failure of HIV-1 to replicate in cell_typepurified DCs . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2705 | 20.1715 | 1.0000 | Coexpression of proteinNF-kappa B and Sp1 occurs in the heterologous DC-T-cell syncytia that are induced by HIV-1 . |
| 1.6610 | 10.1191 | 1.0000 | Coexpression of NF-kappa B and proteinSp1 occurs in the heterologous DC-T-cell syncytia that are induced by HIV-1 . |
| Coexpression of NF-kappa B and Sp1 occurs in the cell_typeheterologous DC-T-cell syncytia that are induced by HIV-1 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9286 | 0.9999 | 1.0000 | Since cell_typeDCs and memory T cells frequently traffic together in situ, these unusual heterologous syncytia could develop in infected individuals and lead to chronic HIV-1 replication without ostensible immune stimulation . |
| 4.1556 | 20.1924 | 10.8054 | Since DCs and cell_typememory T cells frequently traffic together in situ, these unusual heterologous syncytia could develop in infected individuals and lead to chronic HIV-1 replication without ostensible immune stimulation . |
| Since DCs and memory cell_typeT cells frequently traffic together in situ, these unusual heterologous syncytia could develop in infected individuals and lead to chronic HIV-1 replication without ostensible immune stimulation . | |||
| Since DCs and memory T cells frequently traffic together in situ, these unusual cell_typeheterologous syncytia could develop in infected individuals and lead to chronic HIV-1 replication without ostensible immune stimulation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6784 | 20.9210 | 10.6669 | Cupric ion blocks NF kappa B activation through inhibiting the signal-induced phosphorylation of proteinI kappa B alpha . |
| 3.3733 | 20.9257 | 10.5312 | Cupric ion blocks proteinNF kappa B activation through inhibiting the signal-induced phosphorylation of I kappa B alpha . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1724 | 20.1480 | 0.9999 | A transcription factor NF kappa B , which regulates expression of various cellular genes involved in immune responses and DNAviral genes including HIV , is sequestered in the cytoplasm as a complex with an inhibitory protein I kappa B . |
| 1.6432 | 0.9265 | 10.4954 | A transcription factor proteinNF kappa B , which regulates expression of various cellular genes involved in immune responses and viral genes including HIV , is sequestered in the cytoplasm as a complex with an inhibitory protein I kappa B . |
| 1.4738 | 10.4953 | 0.9991 | A proteintranscription factor NF kappa B , which regulates expression of various cellular genes involved in immune responses and viral genes including HIV , is sequestered in the cytoplasm as a complex with an inhibitory protein I kappa B . |
| 2.1438 | 20.6289 | 0.9999 | A transcription factor NF kappa B , which regulates expression of various DNAcellular genes involved in immune responses and viral genes including HIV , is sequestered in the cytoplasm as a complex with an inhibitory protein I kappa B . |
| 1.6250 | 10.3912 | 0.9996 | A transcription factor NF kappa B , which regulates expression of various cellular genes involved in immune responses and viral genes including HIV , is sequestered in the cytoplasm as a complex with an inhibitory protein proteinI kappa B . |
| A transcription factor NF kappa B , which regulates expression of various cellular genes involved in immune responses and viral genes including HIV , is sequestered in the cytoplasm as a complex with an proteininhibitory protein I kappa B . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6945 | 20.9418 | 10.6257 | Various extracellular signals induce phosphorylation and rapid degradation of proteinI kappa B alpha to release NF kappa B . |
| 3.3207 | 20.3583 | 10.8974 | Various extracellular signals induce phosphorylation and rapid degradation of I kappa B alpha to release proteinNF kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8402 | 20.6145 | 10.5562 | Cu2+ was found to inhibit the activation of proteinNF kappa B induced by TNF-alpha , TPA , or H2O2 . |
| 1.7057 | 10.2790 | 1.0000 | Cu2+ was found to inhibit the activation of NF kappa B induced by proteinTNF-alpha , TPA , or H2O2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0304 | 20.4665 | 10.6853 | Deoxycholate treatment of the cytoplasmic extract prepared from cells stimulated by TNF-alpha in the presence of Cu2+ resulted in the release of NF kappa B from proteinI kappa B alpha , indicating that Cu2+ interferes with the dissociation of the NF kappa B -I kappa B complex . |
| 3.7831 | 30.2539 | 10.2558 | Deoxycholate treatment of the cytoplasmic extract prepared from cells stimulated by TNF-alpha in the presence of Cu2+ resulted in the release of NF kappa B from I kappa B alpha , indicating that Cu2+ interferes with the dissociation of the proteinNF kappa B -I kappa B complex . |
| 3.3485 | 30.1163 | 10.3878 | Deoxycholate treatment of the cytoplasmic extract prepared from cells stimulated by TNF-alpha in the presence of Cu2+ resulted in the release of proteinNF kappa B from I kappa B alpha , indicating that Cu2+ interferes with the dissociation of the NF kappa B -I kappa B complex . |
| 3.0962 | 30.9119 | 10.0663 | Deoxycholate treatment of the cytoplasmic extract prepared from cells stimulated by TNF-alpha in the presence of Cu2+ resulted in the release of NF kappa B from I kappa B alpha , indicating that Cu2+ interferes with the dissociation of the proteinNF kappa B -I kappa B complex . |
| 1.4820 | 10.6986 | 1.0000 | Deoxycholate treatment of the cytoplasmic extract prepared from cells stimulated by proteinTNF-alpha in the presence of Cu2+ resulted in the release of NF kappa B from I kappa B alpha , indicating that Cu2+ interferes with the dissociation of the NF kappa B -I kappa B complex . |
| 1.4938 | 0.9788 | 10.8480 | Deoxycholate treatment of the cytoplasmic extract prepared from cells stimulated by TNF-alpha in the presence of Cu2+ resulted in the release of NF kappa B from I kappa B alpha , indicating that Cu2+ interferes with the dissociation of the NF kappa B protein-I kappa B complex . |
| 0.5443 | 0.9959 | 10.5145 | Deoxycholate treatment of the cytoplasmic extract prepared from cells stimulated by TNF-alpha in the presence of Cu2+ resulted in the release of NF kappa B from I kappa B alpha , indicating that Cu2+ interferes with the dissociation of the NF kappa B protein-I kappa B complex . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7526 | 20.8754 | 10.9517 | Neither phosphorylation nor degradation of proteinI kappa B alpha was observed upon TNF-alpha stimulation in the presence of Cu2+ . |
| 0.8165 | 0.9999 | 1.0000 | Neither phosphorylation nor degradation of I kappa B alpha was observed upon proteinTNF-alpha stimulation in the presence of Cu2+ . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9079 | 20.6526 | 10.9200 | These results indicate that Cu2+ inhibits the release of NF kappa B by blockade of a signal leading to the phosphorylation of proteinI kappa B alpha . |
| 3.6133 | 20.9090 | 10.4658 | These results indicate that Cu2+ inhibits the release of proteinNF kappa B by blockade of a signal leading to the phosphorylation of I kappa B alpha . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3446 | 10.6129 | 0.9999 | Cloning a DNAcDNA from human NK/ T cells which codes for a protein with high proline content . |
| 4.5607 | 20.4585 | 20.2222 | Cloning a cDNA from cell_typehuman NK/ T cells which codes for a protein with high proline content . |
| Cloning a cDNA from human cell_typeNK/ T cells which codes for a protein with high proline content . | |||
| Cloning a cDNA from human NK/ cell_typeT cells which codes for a protein with high proline content . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.9343 | 30.4269 | 20.6243 | A cDNA clone , B4-2 , was isolated from a DNAnatural killer (NK) minus T cell subtractive library . |
| 1.6159 | 10.0329 | 1.0000 | A cDNA clone , DNAB4-2 , was isolated from a natural killer (NK) minus T cell subtractive library . |
| 1.2952 | 10.3800 | 0.9999 | A DNAcDNA clone , B4-2 , was isolated from a natural killer (NK) minus T cell subtractive library . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7706 | 10.3864 | 1.0000 | The B4-2 clone coded for an RNAmRNA of 2061 bp in length. |
| 1.5721 | 10.3350 | 1.0000 | The DNAB4-2 clone coded for an mRNA of 2061 bp in length. |
| The DNAB4-2 clone coded for an mRNA of 2061 bp in length. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0275 | 10.9792 | 10.7234 | It encodes a deduced protein327 aa protein with a calculated molecular mass of 35.2 kDa. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5532 | 10.8750 | 0.9999 | Searching of DNAB4-2 DNA and protein sequences against various databases revealed no high homology to other sequences. |
| 1.4792 | 10.7005 | 0.9999 | Searching of B4-2 DNA and DNAprotein sequences against various databases revealed no high homology to other sequences. |
| Searching of DNAB4-2 DNA and protein sequences against various databases revealed no high homology to other sequences. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2953 | 20.9630 | 10.8229 | However, B4-2 has an unusually high proline content (13%), contains a putative nuclear targeting sequence , and has several SPXX motifs which are frequently found in proteingene regulatory proteins . |
| 2.1818 | 20.1819 | 1.0000 | However, B4-2 has an unusually high proline content (13%), contains a putative nuclear targeting sequence , and has several proteinSPXX motifs which are frequently found in gene regulatory proteins . |
| 1.5044 | 10.0621 | 10.6033 | However, B4-2 has an unusually high proline content (13%), contains a putative proteinnuclear targeting sequence , and has several SPXX motifs which are frequently found in gene regulatory proteins . |
| 0.8835 | 0.9999 | 1.0000 | However, proteinB4-2 has an unusually high proline content (13%), contains a putative nuclear targeting sequence , and has several SPXX motifs which are frequently found in gene regulatory proteins . |
| However, DNAB4-2 has an unusually high proline content (13%), contains a putative nuclear targeting sequence , and has several SPXX motifs which are frequently found in gene regulatory proteins . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5609 | 10.7171 | 0.9999 | One of the stretches of prolines in B4-2 closely resembles the ligand for proteins with proteinSH3 domains . |
| 1.5659 | 10.7648 | 1.0000 | One of the stretches of prolines in proteinB4-2 closely resembles the ligand for proteins with SH3 domains . |
| One of the stretches of prolines in DNAB4-2 closely resembles the ligand for proteins with SH3 domains . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8098 | 20.8841 | 10.4927 | Northern hybridization data showed that B4-2 is not a lymphoid specific gene and is expressed in a cell_linehepatoma cell line and also weakly transcribed or absent in a variety of other cells. |
| 3.6838 | 20.8914 | 10.5241 | Northern hybridization data showed that B4-2 is not a DNAlymphoid specific gene and is expressed in a hepatoma cell line and also weakly transcribed or absent in a variety of other cells. |
| 1.6144 | 10.3632 | 1.0000 | Northern hybridization data showed that proteinB4-2 is not a lymphoid specific gene and is expressed in a hepatoma cell line and also weakly transcribed or absent in a variety of other cells. |
| Northern hybridization data showed that DNAB4-2 is not a lymphoid specific gene and is expressed in a hepatoma cell line and also weakly transcribed or absent in a variety of other cells. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4760 | 20.2480 | 10.7972 | A polyclonal antiserum raised against recombinant B4-2 recognizes a protein32-34 kDa protein in lymphocytes . |
| 1.8311 | 20.4640 | 0.9999 | A polyclonal antiserum raised against proteinrecombinant B4-2 recognizes a 32-34 kDa protein in lymphocytes . |
| 1.6668 | 10.0834 | 0.9999 | A polyclonal antiserum raised against recombinant B4-2 recognizes a 32-34 kDa protein in cell_typelymphocytes . |
| 0.9218 | 1.0000 | 1.0000 | A polyclonal antiserum raised against recombinant proteinB4-2 recognizes a 32-34 kDa protein in lymphocytes . |
| A polyclonal antiserum raised against recombinant DNAB4-2 recognizes a 32-34 kDa protein in lymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.7721 | 20.8773 | 10.1383 | Activation of JAK3 , but not JAK1 , is critical for IL-2 -induced proliferation and STAT5 recruitment by a COOH-terminal region of the proteinIL-2 receptor beta-chain . |
| 2.1033 | 20.9442 | 0.9999 | Activation of JAK3 , but not JAK1 , is critical for IL-2 -induced proliferation and STAT5 recruitment by a proteinCOOH-terminal region of the IL-2 receptor beta-chain . |
| 1.5236 | 10.9394 | 1.0000 | Activation of proteinJAK3 , but not JAK1 , is critical for IL-2 -induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain . |
| 1.5229 | 10.3765 | 1.0000 | Activation of JAK3 , but not proteinJAK1 , is critical for IL-2 -induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain . |
| 0.8947 | 1.0000 | 1.0000 | Activation of JAK3 , but not JAK1 , is critical for proteinIL-2 -induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain . |
| 0.8810 | 1.0000 | 1.0000 | Activation of JAK3 , but not JAK1 , is critical for IL-2 -induced proliferation and proteinSTAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain . |
| 1.9123 | 20.5235 | 0.9921 | Activation of JAK3 , but not JAK1 , is critical for IL-2 -induced proliferation and STAT5 recruitment by a COOH-terminal region of the proteinIL-2 receptor beta-chain . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6567 | 10.3953 | 1.0000 | A number of cytokines and growth factors use the proteinJAK -STAT pathway to signal from the cell membrane to the nucleus . |
| 1.6389 | 10.7654 | 1.0000 | A number of proteincytokines and growth factors use the JAK -STAT pathway to signal from the cell membrane to the nucleus . |
| 1.5397 | 10.9072 | 0.9999 | A number of cytokines and proteingrowth factors use the JAK -STAT pathway to signal from the cell membrane to the nucleus . |
| 0.9597 | 1.0000 | 1.0000 | A number of cytokines and growth factors use the JAK protein-STAT pathway to signal from the cell membrane to the nucleus . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1180 | 10.7568 | 10.9746 | While proteinhomodimerizing cytokine receptors may transmit signal via a single form of JAK (i.e. growth hormone receptors ), several multicomponent cytokine receptors have been shown to require simultaneous activation of pairs of different JAK kinases (i.e. interferon receptors ). |
| 3.0631 | 10.6178 | 10.3484 | While homodimerizing cytokine receptors may transmit signal via a single form of JAK (i.e. proteingrowth hormone receptors ), several multicomponent cytokine receptors have been shown to require simultaneous activation of pairs of different JAK kinases (i.e. interferon receptors ). |
| 2.1027 | 20.0503 | 1.0000 | While homodimerizing cytokine receptors may transmit signal via a single form of JAK (i.e. growth hormone receptors ), several multicomponent cytokine receptors have been shown to require simultaneous activation of pairs of different proteinJAK kinases (i.e. interferon receptors ). |
| 2.0731 | 10.4244 | 10.7205 | While homodimerizing cytokine receptors may transmit signal via a single form of JAK (i.e. growth hormone receptors ), several proteinmulticomponent cytokine receptors have been shown to require simultaneous activation of pairs of different JAK kinases (i.e. interferon receptors ). |
| 1.5748 | 10.6239 | 1.0000 | While homodimerizing cytokine receptors may transmit signal via a single form of proteinJAK (i.e. growth hormone receptors ), several multicomponent cytokine receptors have been shown to require simultaneous activation of pairs of different JAK kinases (i.e. interferon receptors ). |
| 1.5218 | 10.4400 | 0.9998 | While homodimerizing cytokine receptors may transmit signal via a single form of JAK (i.e. growth hormone receptors ), several multicomponent cytokine receptors have been shown to require simultaneous activation of pairs of different JAK kinases (i.e. proteininterferon receptors ). |
| 1.0877 | 1.0000 | 10.0160 | While homodimerizing proteincytokine receptors may transmit signal via a single form of JAK (i.e. growth hormone receptors ), several multicomponent cytokine receptors have been shown to require simultaneous activation of pairs of different JAK kinases (i.e. interferon receptors ). |
| 0.6962 | 0.9998 | 1.0000 | While homodimerizing cytokine receptors may transmit signal via a single form of JAK (i.e. growth hormone receptors ), several multicomponent proteincytokine receptors have been shown to require simultaneous activation of pairs of different JAK kinases (i.e. interferon receptors ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6611 | 10.4841 | 1.0000 | Recent evidence for a preferential coupling of JAK3 to interleukin-2 receptor-gamma ( proteinIL-2R gamma ) and JAK1 to IL-2R beta supports the concept of heterotrans-activation of JAK1 and JAK3 caused by IL-2 -induced heterodimerization of their receptor partners . |
| 1.5804 | 10.5026 | 1.0000 | Recent evidence for a preferential coupling of proteinJAK3 to interleukin-2 receptor-gamma ( IL-2R gamma ) and JAK1 to IL-2R beta supports the concept of heterotrans-activation of JAK1 and JAK3 caused by IL-2 -induced heterodimerization of their receptor partners . |
| 1.5664 | 10.3348 | 1.0000 | Recent evidence for a preferential coupling of JAK3 to interleukin-2 receptor-gamma ( IL-2R gamma ) and JAK1 to proteinIL-2R beta supports the concept of heterotrans-activation of JAK1 and JAK3 caused by IL-2 -induced heterodimerization of their receptor partners . |
| 1.5385 | 10.6031 | 1.0000 | Recent evidence for a preferential coupling of JAK3 to proteininterleukin-2 receptor-gamma ( IL-2R gamma ) and JAK1 to IL-2R beta supports the concept of heterotrans-activation of JAK1 and JAK3 caused by IL-2 -induced heterodimerization of their receptor partners . |
| 0.9262 | 1.0000 | 1.0000 | Recent evidence for a preferential coupling of JAK3 to interleukin-2 receptor-gamma ( IL-2R gamma ) and JAK1 to IL-2R beta supports the concept of heterotrans-activation of JAK1 and proteinJAK3 caused by IL-2 -induced heterodimerization of their receptor partners . |
| 0.9228 | 1.0000 | 1.0000 | Recent evidence for a preferential coupling of JAK3 to interleukin-2 receptor-gamma ( IL-2R gamma ) and proteinJAK1 to IL-2R beta supports the concept of heterotrans-activation of JAK1 and JAK3 caused by IL-2 -induced heterodimerization of their receptor partners . |
| 0.9150 | 1.0000 | 1.0000 | Recent evidence for a preferential coupling of JAK3 to interleukin-2 receptor-gamma ( IL-2R gamma ) and JAK1 to IL-2R beta supports the concept of heterotrans-activation of JAK1 and JAK3 caused by proteinIL-2 -induced heterodimerization of their receptor partners . |
| 0.8352 | 0.9999 | 1.0000 | Recent evidence for a preferential coupling of JAK3 to interleukin-2 receptor-gamma ( IL-2R gamma ) and JAK1 to IL-2R beta supports the concept of heterotrans-activation of proteinJAK1 and JAK3 caused by IL-2 -induced heterodimerization of their receptor partners . |
| 1.3793 | 10.8138 | 0.9999 | Recent evidence for a preferential coupling of JAK3 to interleukin-2 receptor-gamma ( IL-2R gamma ) and JAK1 to IL-2R beta supports the concept of heterotrans-activation of JAK1 and JAK3 caused by IL-2 -induced heterodimerization of their proteinreceptor partners . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.0543 | 30.5239 | 10.6649 | The present study verified the ability of IL-2 to cause tyrosine phosphorylation and activation of JAK1 and JAK3 , but demonstrated that IL-2 stimulated JAK3 to a significantly larger extent than JAK1 in human T lymphocytes and the cell_lineYT cell line . |
| 2.1939 | 20.6922 | 0.9997 | The present study verified the ability of IL-2 to cause tyrosine phosphorylation and activation of JAK1 and JAK3 , but demonstrated that IL-2 stimulated JAK3 to a significantly larger extent than JAK1 in cell_typehuman T lymphocytes and the YT cell line . |
| 1.6485 | 10.1193 | 1.0000 | The present study verified the ability of IL-2 to cause tyrosine phosphorylation and activation of JAK1 and JAK3 , but demonstrated that proteinIL-2 stimulated JAK3 to a significantly larger extent than JAK1 in human T lymphocytes and the YT cell line . |
| 1.5940 | 10.5655 | 1.0000 | The present study verified the ability of IL-2 to cause tyrosine phosphorylation and activation of JAK1 and JAK3 , but demonstrated that IL-2 stimulated JAK3 to a significantly larger extent than proteinJAK1 in human T lymphocytes and the YT cell line . |
| 1.5930 | 10.1344 | 1.0000 | The present study verified the ability of IL-2 to cause tyrosine phosphorylation and activation of proteinJAK1 and JAK3 , but demonstrated that IL-2 stimulated JAK3 to a significantly larger extent than JAK1 in human T lymphocytes and the YT cell line . |
| 1.5105 | 10.8826 | 1.0000 | The present study verified the ability of proteinIL-2 to cause tyrosine phosphorylation and activation of JAK1 and JAK3 , but demonstrated that IL-2 stimulated JAK3 to a significantly larger extent than JAK1 in human T lymphocytes and the YT cell line . |
| 0.9029 | 1.0000 | 1.0000 | The present study verified the ability of IL-2 to cause tyrosine phosphorylation and activation of JAK1 and proteinJAK3 , but demonstrated that IL-2 stimulated JAK3 to a significantly larger extent than JAK1 in human T lymphocytes and the YT cell line . |
| 0.8640 | 1.0000 | 1.0000 | The present study verified the ability of IL-2 to cause tyrosine phosphorylation and activation of JAK1 and JAK3 , but demonstrated that IL-2 stimulated proteinJAK3 to a significantly larger extent than JAK1 in human T lymphocytes and the YT cell line . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9518 | 20.2022 | 10.9439 | This conclusion was based upon several independent criteria, including more vigorous tyrosine phosphorylation of JAK3 , more marked enzymatic activation of JAK3 as well as higher abundance of JAK3 in activated proteinIL-2 receptor complexes . |
| 1.5673 | 10.6202 | 1.0000 | This conclusion was based upon several independent criteria, including more vigorous tyrosine phosphorylation of JAK3 , more marked enzymatic activation of JAK3 as well as higher abundance of proteinJAK3 in activated IL-2 receptor complexes . |
| 1.5638 | 10.4723 | 1.0000 | This conclusion was based upon several independent criteria, including more vigorous tyrosine phosphorylation of JAK3 , more marked enzymatic activation of proteinJAK3 as well as higher abundance of JAK3 in activated IL-2 receptor complexes . |
| 1.5474 | 10.6729 | 1.0000 | This conclusion was based upon several independent criteria, including more vigorous tyrosine phosphorylation of proteinJAK3 , more marked enzymatic activation of JAK3 as well as higher abundance of JAK3 in activated IL-2 receptor complexes . |
| 1.4420 | 10.6032 | 0.9965 | This conclusion was based upon several independent criteria, including more vigorous tyrosine phosphorylation of JAK3 , more marked enzymatic activation of JAK3 as well as higher abundance of JAK3 in activated proteinIL-2 receptor complexes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2487 | 20.6622 | 10.9973 | Furthermore, when proteinhuman IL-2R beta was stably expressed in murine BA/F3 cells , robust IL-2 -induced proliferation and JAK3 activation occurred without detectable involvement of either JAK1 , JAK2 or TYK2 . |
| 3.7368 | 20.7609 | 10.8564 | Furthermore, when human IL-2R beta was stably expressed in cell_linemurine BA/F3 cells , robust IL-2 -induced proliferation and JAK3 activation occurred without detectable involvement of either JAK1 , JAK2 or TYK2 . |
| 1.6005 | 10.3152 | 1.0000 | Furthermore, when human IL-2R beta was stably expressed in murine BA/F3 cells , robust IL-2 -induced proliferation and JAK3 activation occurred without detectable involvement of either proteinJAK1 , JAK2 or TYK2 . |
| 1.5387 | 10.1922 | 1.0000 | Furthermore, when human IL-2R beta was stably expressed in murine BA/F3 cells , robust IL-2 -induced proliferation and proteinJAK3 activation occurred without detectable involvement of either JAK1 , JAK2 or TYK2 . |
| 0.9288 | 1.0000 | 1.0000 | Furthermore, when human IL-2R beta was stably expressed in murine BA/F3 cells , robust IL-2 -induced proliferation and JAK3 activation occurred without detectable involvement of either JAK1 , proteinJAK2 or TYK2 . |
| 0.8999 | 1.0000 | 1.0000 | Furthermore, when human IL-2R beta was stably expressed in murine BA/F3 cells , robust proteinIL-2 -induced proliferation and JAK3 activation occurred without detectable involvement of either JAK1 , JAK2 or TYK2 . |
| 0.8705 | 1.0000 | 1.0000 | Furthermore, when human IL-2R beta was stably expressed in murine BA/F3 cells , robust IL-2 -induced proliferation and JAK3 activation occurred without detectable involvement of either JAK1 , JAK2 or proteinTYK2 . |
| 0.5178 | 0.9997 | 0.9998 | Furthermore, when human proteinIL-2R beta was stably expressed in murine BA/F3 cells , robust IL-2 -induced proliferation and JAK3 activation occurred without detectable involvement of either JAK1 , JAK2 or TYK2 . |
| Furthermore, when human proteinIL-2R beta was stably expressed in murine BA/F3 cells , robust IL-2 -induced proliferation and JAK3 activation occurred without detectable involvement of either JAK1 , JAK2 or TYK2 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3184 | 20.1856 | 1.0000 | We therefore propose that proteinIL-2 receptor signal transduction does not depend on equimolar heterodimerization of JAK1 and JAK3 following IL-2 -induced heterodimerization of IL-2R beta and IL-2R gamma . |
| 1.6006 | 10.8034 | 0.9999 | We therefore propose that IL-2 receptor signal transduction does not depend on equimolar heterodimerization of JAK1 and JAK3 following IL-2 -induced heterodimerization of IL-2R beta and proteinIL-2R gamma . |
| 1.5716 | 10.5414 | 1.0000 | We therefore propose that IL-2 receptor signal transduction does not depend on equimolar heterodimerization of proteinJAK1 and JAK3 following IL-2 -induced heterodimerization of IL-2R beta and IL-2R gamma . |
| 1.4830 | 10.9901 | 1.0000 | We therefore propose that IL-2 receptor signal transduction does not depend on equimolar heterodimerization of JAK1 and JAK3 following IL-2 -induced heterodimerization of proteinIL-2R beta and IL-2R gamma . |
| 0.9521 | 1.0000 | 1.0000 | We therefore propose that IL-2 receptor signal transduction does not depend on equimolar heterodimerization of JAK1 and JAK3 following proteinIL-2 -induced heterodimerization of IL-2R beta and IL-2R gamma . |
| 0.9194 | 1.0000 | 1.0000 | We therefore propose that IL-2 receptor signal transduction does not depend on equimolar heterodimerization of JAK1 and proteinJAK3 following IL-2 -induced heterodimerization of IL-2R beta and IL-2R gamma . |
| We therefore propose that IL-2 receptor signal transduction does not depend on equimolar heterodimerization of JAK1 and JAK3 following IL-2 -induced heterodimerization of proteinIL-2R beta and IL-2R gamma . | |||
| We therefore propose that proteinIL-2 receptor signal transduction does not depend on equimolar heterodimerization of JAK1 and JAK3 following IL-2 -induced heterodimerization of IL-2R beta and IL-2R gamma . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5790 | 20.6301 | 10.6120 | Nonetheless, a membrane-proximal region of human IL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation, and the amount of JAK3 present in activated proteinIL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the receptor complex relies on both IL-2R beta and IL-2R gamma . |
| 2.2253 | 20.1536 | 1.0000 | Nonetheless, a membrane-proximal region of human IL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation, and the amount of JAK3 present in activated IL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the proteinreceptor complex relies on both IL-2R beta and IL-2R gamma . |
| 2.1916 | 20.3047 | 1.0000 | Nonetheless, a membrane-proximal region of human IL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation, and the amount of JAK3 present in activated IL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the receptor complex relies on both proteinIL-2R beta and IL-2R gamma . |
| 2.1574 | 20.1549 | 0.9999 | Nonetheless, a proteinmembrane-proximal region of human IL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation, and the amount of JAK3 present in activated IL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the receptor complex relies on both IL-2R beta and IL-2R gamma . |
| 2.0040 | 20.6986 | 0.9958 | Nonetheless, a membrane-proximal region of human IL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation, and the amount of JAK3 present in activated proteinIL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the receptor complex relies on both IL-2R beta and IL-2R gamma . |
| 1.6066 | 10.1980 | 1.0000 | Nonetheless, a membrane-proximal region of human IL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation, and the amount of JAK3 present in activated IL-2 receptor complexes increased with time, suggesting that stabilization of proteinJAK3 binding to the receptor complex relies on both IL-2R beta and IL-2R gamma . |
| 1.6048 | 10.5732 | 1.0000 | Nonetheless, a membrane-proximal region of human IL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation, and the amount of JAK3 present in activated IL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the receptor complex relies on both IL-2R beta and proteinIL-2R gamma . |
| 1.5450 | 10.4592 | 1.0000 | Nonetheless, a membrane-proximal region of human IL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation, and the amount of proteinJAK3 present in activated IL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the receptor complex relies on both IL-2R beta and IL-2R gamma . |
| 0.8919 | 1.0000 | 1.0000 | Nonetheless, a membrane-proximal region of human IL-2R beta ( Asn240-Leu335 ) was critical for proteinJAK3 activation, and the amount of JAK3 present in activated IL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the receptor complex relies on both IL-2R beta and IL-2R gamma . |
| 0.7345 | 1.0000 | 0.9999 | Nonetheless, a membrane-proximal region of human proteinIL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation, and the amount of JAK3 present in activated IL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the receptor complex relies on both IL-2R beta and IL-2R gamma . |
| 0.6125 | 1.0000 | 1.0000 | Nonetheless, a membrane-proximal region of human IL-2R beta ( proteinAsn240-Leu335 ) was critical for JAK3 activation, and the amount of JAK3 present in activated IL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the receptor complex relies on both IL-2R beta and IL-2R gamma . |
| 3.0650 | 10.4235 | 10.4947 | Nonetheless, a membrane-proximal region of proteinhuman IL-2R beta ( Asn240-Leu335 ) was critical for JAK3 activation, and the amount of JAK3 present in activated IL-2 receptor complexes increased with time, suggesting that stabilization of JAK3 binding to the receptor complex relies on both IL-2R beta and IL-2R gamma . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9177 | 20.5613 | 10.2019 | Moreover, STAT5 was found to be the predominant STAT transcription factor used by IL-2 in cell_typehuman T cells , and specifically required a COOH-terminal region of IL-2R beta ( Ser386-Val525 ), while STAT5 recruitment was not correlated to activation of IL-2R gamma or JAK3 . |
| 2.8015 | 20.8865 | 10.2779 | Moreover, STAT5 was found to be the predominant proteinSTAT transcription factor used by IL-2 in human T cells , and specifically required a COOH-terminal region of IL-2R beta ( Ser386-Val525 ), while STAT5 recruitment was not correlated to activation of IL-2R gamma or JAK3 . |
| 2.1172 | 20.1778 | 1.0000 | Moreover, STAT5 was found to be the predominant STAT transcription factor used by IL-2 in human T cells , and specifically required a proteinCOOH-terminal region of IL-2R beta ( Ser386-Val525 ), while STAT5 recruitment was not correlated to activation of IL-2R gamma or JAK3 . |
| 2.1017 | 20.6146 | 1.0000 | Moreover, STAT5 was found to be the predominant STAT transcription factor used by IL-2 in human T cells , and specifically required a COOH-terminal region of IL-2R beta ( Ser386-Val525 ), while STAT5 recruitment was not correlated to activation of proteinIL-2R gamma or JAK3 . |
| 1.5280 | 10.7667 | 1.0000 | Moreover, STAT5 was found to be the predominant STAT transcription factor used by IL-2 in human T cells , and specifically required a COOH-terminal region of proteinIL-2R beta ( Ser386-Val525 ), while STAT5 recruitment was not correlated to activation of IL-2R gamma or JAK3 . |
| 0.9263 | 1.0000 | 1.0000 | Moreover, STAT5 was found to be the predominant STAT transcription factor used by IL-2 in human T cells , and specifically required a COOH-terminal region of IL-2R beta ( Ser386-Val525 ), while proteinSTAT5 recruitment was not correlated to activation of IL-2R gamma or JAK3 . |
| 0.9182 | 1.0000 | 1.0000 | Moreover, proteinSTAT5 was found to be the predominant STAT transcription factor used by IL-2 in human T cells , and specifically required a COOH-terminal region of IL-2R beta ( Ser386-Val525 ), while STAT5 recruitment was not correlated to activation of IL-2R gamma or JAK3 . |
| 0.8451 | 0.9999 | 1.0000 | Moreover, STAT5 was found to be the predominant STAT transcription factor used by proteinIL-2 in human T cells , and specifically required a COOH-terminal region of IL-2R beta ( Ser386-Val525 ), while STAT5 recruitment was not correlated to activation of IL-2R gamma or JAK3 . |
| 0.8294 | 1.0000 | 1.0000 | Moreover, STAT5 was found to be the predominant STAT transcription factor used by IL-2 in human T cells , and specifically required a COOH-terminal region of IL-2R beta ( Ser386-Val525 ), while STAT5 recruitment was not correlated to activation of IL-2R gamma or proteinJAK3 . |
| Moreover, STAT5 was found to be the predominant STAT transcription factor used by IL-2 in human T cells , and specifically required a COOH-terminal region of IL-2R beta ( proteinSer386-Val525 ), while STAT5 recruitment was not correlated to activation of IL-2R gamma or JAK3 . | |||
| Moreover, STAT5 was found to be the predominant STAT transcription factor used by IL-2 in human cell_typeT cells , and specifically required a COOH-terminal region of IL-2R beta ( Ser386-Val525 ), while STAT5 recruitment was not correlated to activation of IL-2R gamma or JAK3 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9431 | 20.4677 | 10.8822 | Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in cell_typeactivated human T lymphocytes . |
| Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated cell_typehuman T lymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1324 | 40.8728 | 20.4156 | DHEA binding sites were examined using a whole-cell binding assay in a cell_linehuman T lymphoid cell line , PEER , revealing that a single class of high-affinity binding sites for DHEA (dissociation constant = 7.4 +/- 0.53 nmol/L, mean +/- SE, n = 4) was greatly increased when treated with DHEA , phorbol-12-myristate-13-acetate , and the Ca2+ ionophore A23187. |
| 0.9329 | 1.0000 | 1.0000 | DHEA binding sites were examined using a whole-cell binding assay in a human T lymphoid cell line , cell_linePEER , revealing that a single class of high-affinity binding sites for DHEA (dissociation constant = 7.4 +/- 0.53 nmol/L, mean +/- SE, n = 4) was greatly increased when treated with DHEA , phorbol-12-myristate-13-acetate , and the Ca2+ ionophore A23187. |
| 2.8528 | 40.0453 | 10.0345 | DHEA binding sites were examined using a whole-cell binding assay in a human T lymphoid cell line , PEER , revealing that a single class of proteinhigh-affinity binding sites for DHEA (dissociation constant = 7.4 +/- 0.53 nmol/L, mean +/- SE, n = 4) was greatly increased when treated with DHEA , phorbol-12-myristate-13-acetate , and the Ca2+ ionophore A23187. |
| 0.7758 | 0.9900 | 0.9996 | proteinDHEA binding sites were examined using a whole-cell binding assay in a human T lymphoid cell line , PEER , revealing that a single class of high-affinity binding sites for DHEA (dissociation constant = 7.4 +/- 0.53 nmol/L, mean +/- SE, n = 4) was greatly increased when treated with DHEA , phorbol-12-myristate-13-acetate , and the Ca2+ ionophore A23187. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5337 | 20.3779 | 1.0000 | These results not only indicate the existence of a DHEA receptor , but also suggest that cell_typeT cells become susceptible to regulation by DHEA during the process of signal-induced activation . |
| 2.1469 | 20.3404 | 1.0000 | These results not only indicate the existence of a proteinDHEA receptor , but also suggest that T cells become susceptible to regulation by DHEA during the process of signal-induced activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6602 | 20.6569 | 0.9903 | Ubiquitin-mediated processing of proteinNF-kappa B transcriptional activator precursor p105 . |
| 0.9151 | 0.9995 | 0.9999 | Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor proteinp105 . |
| 2.5280 | 20.7530 | 10.0812 | Ubiquitin-mediated processing of proteinNF-kappa B transcriptional activator precursor p105 . |
| Ubiquitin-mediated processing of NF-kappa B proteintranscriptional activator precursor p105 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2358 | 20.0965 | 1.0000 | Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein , E2 , and a novel proteinubiquitin-protein ligase , E3 , involved in conjugation. |
| 2.2023 | 20.1185 | 1.0000 | Reconstitution of a cell-free system and identification of the proteinubiquitin-carrier protein , E2 , and a novel ubiquitin-protein ligase , E3 , involved in conjugation. |
| 0.9590 | 1.0000 | 1.0000 | Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein , proteinE2 , and a novel ubiquitin-protein ligase , E3 , involved in conjugation. |
| 0.9511 | 1.0000 | 1.0000 | Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein , E2 , and a novel ubiquitin-protein ligase , proteinE3 , involved in conjugation. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1813 | 20.5265 | 0.9997 | In most cases, the proteintranscriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65 , which are encoded by two distinct genes of the Rel family . |
| 1.7577 | 10.0182 | 1.0000 | In most cases, the transcriptional factor NF-kappa B is a proteinheterodimer consisting of two subunits, p50 and p65 , which are encoded by two distinct genes of the Rel family . |
| 0.9745 | 1.0000 | 1.0000 | In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and proteinp65 , which are encoded by two distinct genes of the Rel family . |
| 0.9642 | 1.0000 | 1.0000 | In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, proteinp50 and p65 , which are encoded by two distinct genes of the Rel family . |
| 0.9164 | 0.9992 | 1.0000 | In most cases, the transcriptional factor proteinNF-kappa B is a heterodimer consisting of two subunits, p50 and p65 , which are encoded by two distinct genes of the Rel family . |
| In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65 , which are encoded by two distinct genes of the DNARel family . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4083 | 10.9260 | 0.9999 | p50 is translated as a precursor of protein105 kDa . |
| 0.9762 | 1.0000 | 1.0000 | proteinp50 is translated as a precursor of 105 kDa . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1006 | 20.6082 | 10.2467 | The C-terminal domain of the precursor is rapidly degraded, forming the proteinmature p50 subunit consisted of the N-terminal region of the molecule. |
| 2.0893 | 20.2047 | 0.9999 | The C-terminal domain of the precursor is rapidly degraded, forming the mature p50 subunit consisted of the proteinN-terminal region of the molecule. |
| 1.5043 | 10.4451 | 1.0000 | The proteinC-terminal domain of the precursor is rapidly degraded, forming the mature p50 subunit consisted of the N-terminal region of the molecule. |
| 0.9279 | 1.0000 | 0.9812 | The C-terminal domain of the precursor is rapidly degraded, forming the mature proteinp50 subunit consisted of the N-terminal region of the molecule. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4463 | 10.6816 | 1.0000 | The mechanism of generation of proteinp50 is not known. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8611 | 1.0000 | 1.0000 | It has been suggested that the ubiquitin -proteasome system is involved in the process; however, the specific proteinenzymes involved and the mechanism of limited proteolysis , in which half of the molecule is spared, have been obscure. |
| 0.8083 | 1.0000 | 0.9995 | It has been suggested that the proteinubiquitin -proteasome system is involved in the process; however, the specific enzymes involved and the mechanism of limited proteolysis , in which half of the molecule is spared, have been obscure. |
| 0.7616 | 1.0000 | 0.9984 | It has been suggested that the ubiquitin protein-proteasome system is involved in the process; however, the specific enzymes involved and the mechanism of limited proteolysis , in which half of the molecule is spared, have been obscure. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6743 | 10.8004 | 0.9999 | Palombella and colleagues (Palombella, V.J., Rando, O.J., Goldberg, A.L., and Maniatis, T.(1994) Cell 78, 773-785) have shown that ubiquitin is required for the processing in a cell-free system of a truncated, artificially constructed, protein60-kDa precursor . |
| 0.8992 | 1.0000 | 1.0000 | Palombella and colleagues (Palombella, V.J., Rando, O.J., Goldberg, A.L., and Maniatis, T.(1994) Cell 78, 773-785) have shown that proteinubiquitin is required for the processing in a cell-free system of a truncated, artificially constructed, 60-kDa precursor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8492 | 1.0000 | 1.0000 | They have also shown that proteinproteasome inhibitors block the processing both in vitro and in vivo. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4764 | 20.9941 | 10.3873 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately 320-kDa species of proteinubiquitin -protein ligase , is involved in the process. |
| 2.4623 | 20.0418 | 0.9999 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact proteinp105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately 320-kDa species of ubiquitin -protein ligase , is involved in the process. |
| 2.3726 | 30.8848 | 10.5909 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the proteinubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately 320-kDa species of ubiquitin -protein ligase , is involved in the process. |
| 2.3077 | 20.8208 | 0.9958 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the proteinubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately 320-kDa species of ubiquitin -protein ligase , is involved in the process. |
| 2.2372 | 20.7912 | 1.0000 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the proteinp105 precursor , and (d) a novel, approximately 320-kDa species of ubiquitin -protein ligase , is involved in the process. |
| 1.7584 | 10.3008 | 1.0000 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of proteinp53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately 320-kDa species of ubiquitin -protein ligase , is involved in the process. |
| 1.0863 | 10.8893 | 0.9924 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately 320-kDa species of proteinubiquitin -protein ligase , is involved in the process. |
| 0.9722 | 1.0000 | 1.0000 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , proteinE2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately 320-kDa species of ubiquitin -protein ligase , is involved in the process. |
| 0.9020 | 1.0000 | 1.0000 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of proteinubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately 320-kDa species of ubiquitin -protein ligase , is involved in the process. |
| 0.8391 | 1.0000 | 0.9999 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the proteinubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately 320-kDa species of ubiquitin -protein ligase , is involved in the process. |
| 3.0766 | 30.0626 | 0.9941 | In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the proteinp105 precursor , and (d) a novel, approximately 320-kDa species of ubiquitin -protein ligase , is involved in the process. |
| In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin -proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately protein320-kDa species of ubiquitin -protein ligase , is involved in the process. | |||
| In this study, we demonstrate reconstitution of a cell-free processing system and demonstrate directly that: (a) the ubiquitin protein-proteasome system is involved in processing of the intact p105 precursor, (b) conjugation of ubiquitin to the precursor is an essential intermediate step in the processing, (c) the recently discovered novel species of the ubiquitin -carrier protein , E2-F1 , that is involved in the conjugation and degradation of p53 , is also required for the limited processing of the p105 precursor , and (d) a novel, approximately 320-kDa species of ubiquitin -protein ligase , is involved in the process. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5814 | 10.0021 | 0.9999 | This novel enzyme is distinct from E6-AP , the p53 -conjugating ligase , and from E3 alpha , the protein"N-end rule" ligase . |
| 0.8627 | 1.0000 | 1.0000 | This novel enzyme is distinct from proteinE6-AP , the p53 -conjugating ligase , and from E3 alpha , the "N-end rule" ligase . |
| 0.7865 | 0.9997 | 1.0000 | This novel enzyme is distinct from E6-AP , the p53 -conjugating ligase , and from proteinE3 alpha , the "N-end rule" ligase . |
| 0.7564 | 0.9970 | 0.9999 | This novel enzyme is distinct from E6-AP , the proteinp53 -conjugating ligase , and from E3 alpha , the "N-end rule" ligase . |
| 0.6062 | 1.0000 | 0.9985 | This novel enzyme is distinct from E6-AP , the proteinp53 -conjugating ligase , and from E3 alpha , the "N-end rule" ligase . |
| This novel enzyme is distinct from E6-AP , the p53 -conjugating ligase , and from proteinE3 alpha , the "N-end rule" ligase . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4152 | 20.3685 | 1.0000 | Flutamide in the treatment of hirsutism : long-term clinical effects , endocrine changes , and proteinandrogen receptor behavior . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6004 | 20.4772 | 1.0000 | OBJECTIVE: To investigate the long-term effects of treatment with low doses of flutamide on clinical and hormonal parameters , as well as on the proteinandrogen receptor status, in hirsute women . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4655 | 20.5127 | 1.0000 | In addition, the concentration of proteinandrogen receptors in mononuclear leukocytes was measured, in both the follicular and luteal phases of the menstrual cycle , basally and after 4 months of flutamide treatment. |
| 1.7231 | 10.8423 | 0.9999 | In addition, the concentration of androgen receptors in cell_typemononuclear leukocytes was measured, in both the follicular and luteal phases of the menstrual cycle , basally and after 4 months of flutamide treatment. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5414 | 20.6019 | 1.0000 | RESULTS: Flutamide was well tolerated in all women , with the noticeable exception of one patient who presented increased proteinserum transaminase after 8 months of therapy . |
| RESULTS: Flutamide was well tolerated in all women , with the noticeable exception of one patient who presented increased serum transaminase after 8 months of proteintherapy . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2863 | 20.1162 | 1.0000 | A reduction of serum androgens was found, whereas no change was observed in either basal or proteinGnRH-stimulated gonadotropins or in the cortisol and 17 alpha-hydroxyprogesterone response to ACTH . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4725 | 20.4024 | 1.0000 | Before treatment, the number of proteinandrogen receptors was higher in the luteal than in the follicular phase . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9156 | 0.9997 | 1.0000 | proteinAndrogen receptor blockade might be potentiated by a reduction of serum androgens . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5708 | 10.6652 | 1.0000 | Flutamide affects proteinandrogen receptor behavior during the menstrual cycle . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0301 | 20.5376 | 10.6752 | Constitutive expression of HIV-1 tat protein in cell_linehuman Jurkat T cells using a BK virus vector . |
| 3.8208 | 20.8760 | 10.8357 | Constitutive expression of proteinHIV-1 tat protein in human Jurkat T cells using a BK virus vector . |
| Constitutive expression of HIV-1 tat protein in human cell_lineJurkat T cells using a BK virus vector . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8709 | 10.6192 | 30.6793 | The production and characterization of Jurkat cell lines that constitutively express functional proteinhuman immune deficiency virus type 1 ( HIV-1 ) tat protein , using a BK virus plasmid expression vector and HIV-1 tat cDNA , is described. |
| 1.9300 | 10.1174 | 10.7562 | The production and characterization of cell_lineJurkat cell lines that constitutively express functional human immune deficiency virus type 1 ( HIV-1 ) tat protein , using a BK virus plasmid expression vector and HIV-1 tat cDNA , is described. |
| 1.3510 | 20.3144 | 0.9997 | The production and characterization of Jurkat cell lines that constitutively express functional human immune deficiency virus type 1 ( HIV-1 ) tat protein , using a BK virus plasmid expression vector and DNAHIV-1 tat cDNA , is described. |
| 4.3434 | 40.6071 | 20.9804 | The production and characterization of Jurkat cell lines that constitutively express functional human immune deficiency virus type 1 ( HIV-1 ) tat protein , using a DNABK virus plasmid expression vector and HIV-1 tat cDNA , is described. |
| The production and characterization of Jurkat cell lines that constitutively express functional human immune deficiency virus type 1 ( HIV-1 ) proteintat protein , using a BK virus plasmid expression vector and HIV-1 tat cDNA , is described. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2286 | 20.1666 | 10.6024 | An increased growth rate of these Jurkat-tat cell lines as compared with cell_linecontrol cell lines was observed. |
| 3.6277 | 20.2852 | 10.6007 | An increased growth rate of these cell_lineJurkat-tat cell lines as compared with control cell lines was observed. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3796 | 20.8964 | 10.2864 | A PEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an DNAosteoblast-specific cis-acting element . |
| 3.0206 | 10.9282 | 10.8172 | A proteinPEBP2 alpha/AML-1-related factor increases osteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element . |
| 1.4130 | 10.9233 | 0.9998 | A PEBP2 alpha/AML-1-related factor increases DNAosteocalcin promoter activity through its binding to an osteoblast-specific cis-acting element . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2620 | 20.5671 | 10.9465 | To identify osteoblast-specific cis-acting elements and trans-acting factors , we initiated an analysis of the promoter of a DNAmouse osteocalcin gene , an osteoblast-specific gene . |
| 3.3962 | 20.4548 | 10.6319 | To identify DNAosteoblast-specific cis-acting elements and trans-acting factors , we initiated an analysis of the promoter of a mouse osteocalcin gene , an osteoblast-specific gene . |
| 2.0689 | 20.4267 | 0.9997 | To identify osteoblast-specific cis-acting elements and trans-acting factors , we initiated an analysis of the promoter of a mouse osteocalcin gene , an DNAosteoblast-specific gene . |
| 1.4521 | 10.0991 | 0.9998 | To identify osteoblast-specific cis-acting elements and proteintrans-acting factors , we initiated an analysis of the promoter of a mouse osteocalcin gene , an osteoblast-specific gene . |
| 0.7948 | 0.9999 | 1.0000 | To identify osteoblast-specific cis-acting elements and trans-acting factors , we initiated an analysis of the DNApromoter of a mouse osteocalcin gene , an osteoblast-specific gene . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2638 | 10.5838 | 10.5145 | In this promoter, we identified two DNAosteoblast-specific cis-acting elements (Ducy, P.and Karsenty, G.(1995) Mol.Cell.Biol.15, 1858-1869). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9284 | 20.5696 | 10.6478 | The sequence of one of these elements , OSE2 , is identical to the DNA-binding site of the proteinPEBP2 alpha/AML-1 transcription factors , the mammalian homologues of the Drosophila Runt protein . |
| 3.2999 | 20.9540 | 10.9868 | The sequence of one of these elements , OSE2 , is identical to the DNA-binding site of the PEBP2 alpha/AML-1 transcription factors , the mammalian homologues of the proteinDrosophila Runt protein . |
| 2.1256 | 20.0730 | 0.9998 | The sequence of one of these elements , OSE2 , is identical to the DNADNA-binding site of the PEBP2 alpha/AML-1 transcription factors , the mammalian homologues of the Drosophila Runt protein . |
| 1.7236 | 10.6167 | 1.0000 | The sequence of one of these elements , DNAOSE2 , is identical to the DNA-binding site of the PEBP2 alpha/AML-1 transcription factors , the mammalian homologues of the Drosophila Runt protein . |
| 2.1702 | 20.0331 | 0.9983 | The sequence of one of these elements , OSE2 , is identical to the DNA-binding site of the proteinPEBP2 alpha/AML-1 transcription factors , the mammalian homologues of the Drosophila Runt protein . |
| 0.7903 | 0.9914 | 0.9999 | The sequence of one of these elements , OSE2 , is identical to the DNA-binding site of the PEBP2 alpha/AML-1 proteintranscription factors , the mammalian homologues of the Drosophila Runt protein . |
| The sequence of one of these DNAelements , OSE2 , is identical to the DNA-binding site of the PEBP2 alpha/AML-1 transcription factors , the mammalian homologues of the Drosophila Runt protein . | |||
| The sequence of one of these elements , OSE2 , is identical to the DNA-binding site of the PEBP2 alpha/AML-1 transcription factors , the proteinmammalian homologues of the Drosophila Runt protein . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4183 | 20.5543 | 1.0000 | Here we show, using nuclear extracts , proteinrecombinant protein , and a specific antiserum against AML-1 proteins in DNA-binding assays , that one member of this family, AML-1B , binds specifically to OSE2 and is immunologically related to OSF2 , the factor present in osteoblast nuclear extracts that binds to OSE2 . |
| 2.3972 | 20.3758 | 1.0000 | Here we show, using nuclear extracts , recombinant protein , and a specific antiserum against proteinAML-1 proteins in DNA-binding assays , that one member of this family, AML-1B , binds specifically to OSE2 and is immunologically related to OSF2 , the factor present in osteoblast nuclear extracts that binds to OSE2 . |
| 1.8468 | 10.1493 | 1.0000 | Here we show, using nuclear extracts , recombinant protein , and a specific antiserum against AML-1 proteins in DNA-binding assays , that one member of this family, AML-1B , binds specifically to OSE2 and is immunologically related to proteinOSF2 , the factor present in osteoblast nuclear extracts that binds to OSE2 . |
| 1.7979 | 10.2512 | 1.0000 | Here we show, using nuclear extracts , recombinant protein , and a specific antiserum against AML-1 proteins in DNA-binding assays , that one member of this family, AML-1B , binds specifically to DNAOSE2 and is immunologically related to OSF2 , the factor present in osteoblast nuclear extracts that binds to OSE2 . |
| 1.7131 | 10.2210 | 1.0000 | Here we show, using nuclear extracts , recombinant protein , and a specific antiserum against AML-1 proteins in DNA-binding assays , that one member of this family, AML-1B , binds specifically to OSE2 and is immunologically related to OSF2 , the factor present in osteoblast nuclear extracts that binds to DNAOSE2 . |
| 0.9594 | 1.0000 | 1.0000 | Here we show, using nuclear extracts , recombinant protein , and a specific antiserum against AML-1 proteins in DNA-binding assays , that one member of this family, proteinAML-1B , binds specifically to OSE2 and is immunologically related to OSF2 , the factor present in osteoblast nuclear extracts that binds to OSE2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6013 | 10.3213 | 1.0000 | By DNA cotransfection experiments , we also demonstrate that AML-1B can increase the activity of a short osteocalcin promoter through its binding to DNAOSE2 . |
| 1.5748 | 10.8438 | 1.0000 | By DNA cotransfection experiments , we also demonstrate that AML-1B can increase the activity of a short DNAosteocalcin promoter through its binding to OSE2 . |
| 0.8596 | 1.0000 | 1.0000 | By DNA cotransfection experiments , we also demonstrate that proteinAML-1B can increase the activity of a short osteocalcin promoter through its binding to OSE2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.4269 | 30.5717 | 10.6756 | Lastly, the different mobilities of osteoblast nuclear extract-DNA complexes compared with proteinT-cell nuclear extract-DNA complexes , along with the inability of OSF2 to be upregulated by retinoic acid , unlike the other PEBP2 alpha factors , suggest that OSF2 is a new member of this family of transcription factors . |
| 4.6723 | 20.7820 | 10.4023 | Lastly, the different mobilities of proteinosteoblast nuclear extract-DNA complexes compared with T-cell nuclear extract-DNA complexes , along with the inability of OSF2 to be upregulated by retinoic acid , unlike the other PEBP2 alpha factors , suggest that OSF2 is a new member of this family of transcription factors . |
| 2.9608 | 20.5007 | 10.6260 | Lastly, the different mobilities of osteoblast nuclear extract-DNA complexes compared with T-cell nuclear extract-DNA complexes , along with the inability of OSF2 to be upregulated by retinoic acid , unlike the other proteinPEBP2 alpha factors , suggest that OSF2 is a new member of this family of transcription factors . |
| 1.4989 | 10.3113 | 1.0000 | Lastly, the different mobilities of osteoblast nuclear extract-DNA complexes compared with T-cell nuclear extract-DNA complexes , along with the inability of proteinOSF2 to be upregulated by retinoic acid , unlike the other PEBP2 alpha factors , suggest that OSF2 is a new member of this family of transcription factors . |
| 1.4643 | 10.8055 | 0.9999 | Lastly, the different mobilities of osteoblast nuclear extract-DNA complexes compared with T-cell nuclear extract-DNA complexes , along with the inability of OSF2 to be upregulated by retinoic acid , unlike the other PEBP2 alpha factors , suggest that OSF2 is a new member of this family of proteintranscription factors . |
| 0.8412 | 1.0000 | 1.0000 | Lastly, the different mobilities of osteoblast nuclear extract-DNA complexes compared with T-cell nuclear extract-DNA complexes , along with the inability of OSF2 to be upregulated by retinoic acid , unlike the other PEBP2 alpha factors , suggest that proteinOSF2 is a new member of this family of transcription factors . |
| 2.0118 | 20.6365 | 0.9969 | Lastly, the different mobilities of osteoblast nuclear extract-DNA complexes compared with T-cell nuclear extract-DNA complexes , along with the inability of OSF2 to be upregulated by retinoic acid , unlike the other proteinPEBP2 alpha factors , suggest that OSF2 is a new member of this family of transcription factors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6463 | 20.9161 | 10.6568 | Thus, this study demonstrates that AML-1B can increase gene expression of an osteoblast-specific gene through its binding to an DNAosteoblast-specific cis-acting element and presents evidence that OSF2 is a member of the PEBP2 alpha/AML-1 family of transcription factors . |
| 2.4788 | 30.5019 | 0.9757 | Thus, this study demonstrates that AML-1B can increase gene expression of an osteoblast-specific gene through its binding to an osteoblast-specific cis-acting element and presents evidence that OSF2 is a member of the proteinPEBP2 alpha/AML-1 family of transcription factors . |
| 2.0717 | 20.7693 | 1.0000 | Thus, this study demonstrates that AML-1B can increase gene expression of an DNAosteoblast-specific gene through its binding to an osteoblast-specific cis-acting element and presents evidence that OSF2 is a member of the PEBP2 alpha/AML-1 family of transcription factors . |
| 1.4903 | 10.3728 | 1.0000 | Thus, this study demonstrates that proteinAML-1B can increase gene expression of an osteoblast-specific gene through its binding to an osteoblast-specific cis-acting element and presents evidence that OSF2 is a member of the PEBP2 alpha/AML-1 family of transcription factors . |
| 0.8295 | 0.9921 | 0.9998 | Thus, this study demonstrates that AML-1B can increase gene expression of an osteoblast-specific gene through its binding to an osteoblast-specific cis-acting element and presents evidence that OSF2 is a member of the PEBP2 alpha/AML-1 family of proteintranscription factors . |
| 0.7903 | 1.0000 | 1.0000 | Thus, this study demonstrates that AML-1B can increase gene expression of an osteoblast-specific gene through its binding to an osteoblast-specific cis-acting element and presents evidence that proteinOSF2 is a member of the PEBP2 alpha/AML-1 family of transcription factors . |
| 4.1788 | 30.1657 | 10.9547 | Thus, this study demonstrates that AML-1B can increase gene expression of an osteoblast-specific gene through its binding to an osteoblast-specific cis-acting element and presents evidence that OSF2 is a member of the proteinPEBP2 alpha/AML-1 family of transcription factors . |
| 0.7219 | 1.0000 | 0.9988 | Thus, this study demonstrates that AML-1B can increase gene expression of an osteoblast-specific gene through its binding to an osteoblast-specific cis-acting element and presents evidence that OSF2 is a member of the proteinPEBP2 alpha/AML-1 family of transcription factors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5217 | 30.1780 | 10.8938 | Initiation binding repressor , a factor that binds to the transcription initiation site of the DNAhistone h5 gene , is a glycosylated member of a family of cell growth regulators [corrected] [published erratum appears in Mol Cell Biol 1996 Feb;16(2):735] |
| 3.5630 | 20.9018 | 10.9970 | Initiation binding repressor , a factor that binds to the DNAtranscription initiation site of the histone h5 gene , is a glycosylated member of a family of cell growth regulators [corrected] [published erratum appears in Mol Cell Biol 1996 Feb;16(2):735] |
| 2.2361 | 20.3492 | 10.1001 | Initiation binding repressor , a factor that binds to the transcription initiation site of the histone h5 gene , is a glycosylated member of a family of proteincell growth regulators [corrected] [published erratum appears in Mol Cell Biol 1996 Feb;16(2):735] |
| 1.5836 | 0.9989 | 10.6373 | proteinInitiation binding repressor , a factor that binds to the transcription initiation site of the histone h5 gene , is a glycosylated member of a family of cell growth regulators [corrected] [published erratum appears in Mol Cell Biol 1996 Feb;16(2):735] |
| Initiation binding repressor , a factor that binds to the transcription initiation site of the histone h5 gene , is a proteinglycosylated member of a family of cell growth regulators [corrected] [published erratum appears in Mol Cell Biol 1996 Feb;16(2):735] | |||
| Initiation binding repressor , a factor that binds to the transcription initiation site of the proteinhistone h5 gene , is a glycosylated member of a family of cell growth regulators [corrected] [published erratum appears in Mol Cell Biol 1996 Feb;16(2):735] | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7329 | 20.4637 | 10.7173 | Initiation binding repressor [corrected] ( IBR ) is a chicken erythrocyte factor (apparent molecular mass, 70 to 73 kDa) that binds to the sequences spanning the transcription initiation site of the DNAhistone h5 gene , repressing its transcription . |
| 3.5001 | 20.8177 | 10.7436 | Initiation binding repressor [corrected] ( IBR ) is a proteinchicken erythrocyte factor (apparent molecular mass, 70 to 73 kDa) that binds to the sequences spanning the transcription initiation site of the histone h5 gene , repressing its transcription . |
| 3.4472 | 20.7710 | 10.7553 | Initiation binding repressor [corrected] ( IBR ) is a chicken erythrocyte factor (apparent molecular mass, 70 to 73 kDa) that binds to the sequences spanning the DNAtranscription initiation site of the histone h5 gene , repressing its transcription . |
| 1.5992 | 0.9991 | 10.7189 | proteinInitiation binding repressor [corrected] ( IBR ) is a chicken erythrocyte factor (apparent molecular mass, 70 to 73 kDa) that binds to the sequences spanning the transcription initiation site of the histone h5 gene , repressing its transcription . |
| 0.9514 | 1.0000 | 1.0000 | Initiation binding repressor [corrected] ( proteinIBR ) is a chicken erythrocyte factor (apparent molecular mass, 70 to 73 kDa) that binds to the sequences spanning the transcription initiation site of the histone h5 gene , repressing its transcription . |
| Initiation binding repressor [corrected] ( IBR ) is a chicken erythrocyte factor (apparent molecular mass, 70 to 73 kDa) that binds to the sequences spanning the transcription initiation site of the proteinhistone h5 gene , repressing its transcription . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0361 | 20.3962 | 0.9998 | A variety of other cells, including transformed erythroid precursors , do not have IBR but a factor referred to as IBF (68 to 70 kDa) that recognizes the same proteinIBR sites. |
| 1.6678 | 10.3739 | 0.9999 | A variety of other cells, including transformed erythroid precursors , do not have IBR but a factor referred to as proteinIBF (68 to 70 kDa) that recognizes the same IBR sites. |
| 1.6635 | 10.0502 | 1.0000 | A variety of other cells, including transformed erythroid precursors , do not have proteinIBR but a factor referred to as IBF (68 to 70 kDa) that recognizes the same IBR sites. |
| 3.7755 | 20.8764 | 10.7418 | A variety of other cells, including cell_linetransformed erythroid precursors , do not have IBR but a factor referred to as IBF (68 to 70 kDa) that recognizes the same IBR sites. |
| A variety of other cells, including cell_typetransformed erythroid precursors , do not have IBR but a factor referred to as IBF (68 to 70 kDa) that recognizes the same IBR sites. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1418 | 20.1512 | 1.0000 | We have cloned the DNAIBR cDNA and studied the relationship of IBR and IBF . |
| 2.0424 | 20.0418 | 0.9919 | We have cloned the proteinIBR cDNA and studied the relationship of IBR and IBF . |
| 1.4623 | 10.5998 | 1.0000 | We have cloned the IBR cDNA and studied the relationship of proteinIBR and IBF . |
| 0.8416 | 1.0000 | 1.0000 | We have cloned the IBR cDNA and studied the relationship of IBR and proteinIBF . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6877 | 20.3444 | 10.8298 | IBR is a 503-amino-acid-long acidic protein which is 99.0% identical to the recently reported human NRF-1/alpha-Pal factor and highly related to the invertebrate transcription factors P3A2 and proteinerected wing gene product ( EWG ). |
| 3.6373 | 20.6153 | 10.3064 | IBR is a 503-amino-acid-long acidic protein which is 99.0% identical to the recently reported proteinhuman NRF-1/alpha-Pal factor and highly related to the invertebrate transcription factors P3A2 and erected wing gene product ( EWG ). |
| 3.6119 | 20.9199 | 10.4910 | IBR is a protein503-amino-acid-long acidic protein which is 99.0% identical to the recently reported human NRF-1/alpha-Pal factor and highly related to the invertebrate transcription factors P3A2 and erected wing gene product ( EWG ). |
| 0.9689 | 1.0000 | 1.0000 | proteinIBR is a 503-amino-acid-long acidic protein which is 99.0% identical to the recently reported human NRF-1/alpha-Pal factor and highly related to the invertebrate transcription factors P3A2 and erected wing gene product ( EWG ). |
| 0.9668 | 1.0000 | 1.0000 | IBR is a 503-amino-acid-long acidic protein which is 99.0% identical to the recently reported human NRF-1/alpha-Pal factor and highly related to the invertebrate transcription factors P3A2 and erected wing gene product ( proteinEWG ). |
| 0.9508 | 0.9997 | 1.0000 | IBR is a 503-amino-acid-long acidic protein which is 99.0% identical to the recently reported human NRF-1/alpha-Pal factor and highly related to the invertebrate transcription factors proteinP3A2 and erected wing gene product ( EWG ). |
| 4.0683 | 20.9335 | 10.8906 | IBR is a 503-amino-acid-long acidic protein which is 99.0% identical to the recently reported human NRF-1/alpha-Pal factor and highly related to the proteininvertebrate transcription factors P3A2 and erected wing gene product ( EWG ). |
| IBR is a 503-amino-acid-long acidic protein which is 99.0% identical to the recently reported human NRF-1/alpha-Pal factor and highly related to the invertebrate proteintranscription factors P3A2 and erected wing gene product ( EWG ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7420 | 10.4233 | 1.0000 | We present evidence that proteinIBR and IBF are most likely identical proteins, differing in their degree of glycosylation . |
| 0.9729 | 1.0000 | 1.0000 | We present evidence that IBR and proteinIBF are most likely identical proteins, differing in their degree of glycosylation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5723 | 10.4187 | 1.0000 | We have analyzed several molecular aspects of proteinIBR/F and shown that the factor associates as stable homodimers and that the dimer is the relevant DNA-binding species . |
| 0.8877 | 1.0000 | 1.0000 | We have analyzed several molecular aspects of IBR/F and shown that the factor associates as stable homodimers and that the proteindimer is the relevant DNA-binding species . |
| 0.8723 | 1.0000 | 1.0000 | We have analyzed several molecular aspects of IBR/F and shown that the factor associates as stable proteinhomodimers and that the dimer is the relevant DNA-binding species . |
| 1.5102 | 10.9928 | 0.9999 | We have analyzed several molecular aspects of IBR/F and shown that the factor associates as stable homodimers and that the dimer is the relevant proteinDNA-binding species . |
| We have analyzed several molecular aspects of IBR/F and shown that the factor associates as stable homodimers and that the dimer is the proteinrelevant DNA-binding species . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1678 | 20.9155 | 10.9844 | The evolutionarily conserved N-terminal half of IBR/F harbors the DNA-binding/dimerization domain (outer limits, 127 to 283), one or several casein kinase II sites (37 to 67), and a proteinbipartite nuclear localization signal (89 to 106) which appears to be necessary for nuclear targeting . |
| 1.3592 | 10.8461 | 0.9998 | The evolutionarily conserved N-terminal half of IBR/F harbors the proteinDNA-binding/dimerization domain (outer limits, 127 to 283), one or several casein kinase II sites (37 to 67), and a bipartite nuclear localization signal (89 to 106) which appears to be necessary for nuclear targeting . |
| 0.8759 | 0.9999 | 1.0000 | The evolutionarily conserved N-terminal half of proteinIBR/F harbors the DNA-binding/dimerization domain (outer limits, 127 to 283), one or several casein kinase II sites (37 to 67), and a bipartite nuclear localization signal (89 to 106) which appears to be necessary for nuclear targeting . |
| 0.7753 | 0.9942 | 0.9999 | The evolutionarily conserved proteinN-terminal half of IBR/F harbors the DNA-binding/dimerization domain (outer limits, 127 to 283), one or several casein kinase II sites (37 to 67), and a bipartite nuclear localization signal (89 to 106) which appears to be necessary for nuclear targeting . |
| 1.2531 | 20.7883 | 10.4576 | The evolutionarily conserved N-terminal half of IBR/F harbors the DNA-binding/dimerization domain (outer limits, 127 to 283), one or several proteincasein kinase II sites (37 to 67), and a bipartite nuclear localization signal (89 to 106) which appears to be necessary for nuclear targeting . |
| The evolutionarily conserved N-terminal half of IBR/F harbors the DNA-binding/dimerization domain (outer limits, 127 to 283), one or several proteincasein kinase II sites (37 to 67), and a bipartite nuclear localization signal (89 to 106) which appears to be necessary for nuclear targeting . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9779 | 20.4571 | 0.9998 | Binding site selection revealed that the alternating RCGCRYGCGY consensus constitutes high-affinity IBR/F binding sites and that the DNAdirect-repeat palindrome TGCGCATGCGCA is the optimal site . |
| 1.3476 | 10.4932 | 0.9995 | Binding site selection revealed that the alternating RCGCRYGCGY consensus constitutes high-affinity IBR/F binding sites and that the direct-repeat palindrome TGCGCATGCGCA is the DNAoptimal site . |
| 0.8963 | 1.0000 | 0.9979 | Binding site selection revealed that the alternating RCGCRYGCGY consensus constitutes high-affinity proteinIBR/F binding sites and that the direct-repeat palindrome TGCGCATGCGCA is the optimal site . |
| 4.1256 | 20.4418 | 10.5965 | Binding site selection revealed that the alternating RCGCRYGCGY consensus constitutes DNAhigh-affinity IBR/F binding sites and that the direct-repeat palindrome TGCGCATGCGCA is the optimal site . |
| Binding site selection revealed that the proteinalternating RCGCRYGCGY consensus constitutes high-affinity IBR/F binding sites and that the direct-repeat palindrome TGCGCATGCGCA is the optimal site . | |||
| Binding site selection revealed that the alternating RCGCRYGCGY consensus constitutes high-affinity DNAIBR/F binding sites and that the direct-repeat palindrome TGCGCATGCGCA is the optimal site . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9116 | 1.0000 | 1.0000 | A survey of genes potentially regulated by this family of factors primarily revealed DNAgenes involved in growth-related metabolism . |
| 0.6312 | 0.9998 | 1.0000 | A survey of DNAgenes potentially regulated by this family of factors primarily revealed genes involved in growth-related metabolism . |
| A survey of genes potentially regulated by this family of proteinfactors primarily revealed genes involved in growth-related metabolism . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8477 | 20.8034 | 10.4882 | Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between proteininterferon regulatory factor-1 , NF kappa B , and Sp1 transcription factors . |
| 2.1251 | 10.3902 | 10.4674 | Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1 , proteinNF kappa B , and Sp1 transcription factors . |
| 1.6092 | 20.3449 | 0.9998 | Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1 , NF kappa B , and Sp1 proteintranscription factors . |
| 1.5494 | 10.5743 | 0.9999 | Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1 , NF kappa B , and proteinSp1 transcription factors . |
| 3.3059 | 20.6272 | 10.6014 | Triggering of the DNAhuman interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1 , NF kappa B , and Sp1 transcription factors . |
| 2.7060 | 10.8142 | 10.9371 | Triggering of the human interleukin-6 gene by interferon-gamma and proteintumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1 , NF kappa B , and Sp1 transcription factors . |
| 1.3977 | 10.2376 | 0.9998 | Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in cell_typemonocytic cells involves cooperation between interferon regulatory factor-1 , NF kappa B , and Sp1 transcription factors . |
| 0.9164 | 1.0000 | 1.0000 | Triggering of the human interleukin-6 gene by proteininterferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1 , NF kappa B , and Sp1 transcription factors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9651 | 20.7867 | 10.9242 | We investigated the molecular basis of the synergistic induction by interferon-gamma ( IFN-gamma )/ tumor necrosis factor-alpha ( TNF-alpha ) of DNAhuman interleukin-6 (IL-6) gene in THP-1 monocytic cells , and compared it with the basis of this induction by lipopolysaccharide ( LPS ). |
| 2.8813 | 10.5995 | 10.6271 | We investigated the molecular basis of the synergistic induction by interferon-gamma ( IFN-gamma )/ proteintumor necrosis factor-alpha ( TNF-alpha ) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells , and compared it with the basis of this induction by lipopolysaccharide ( LPS ). |
| 0.9754 | 1.0000 | 1.0000 | We investigated the molecular basis of the synergistic induction by interferon-gamma ( proteinIFN-gamma )/ tumor necrosis factor-alpha ( TNF-alpha ) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells , and compared it with the basis of this induction by lipopolysaccharide ( LPS ). |
| 0.9703 | 1.0000 | 1.0000 | We investigated the molecular basis of the synergistic induction by interferon-gamma ( IFN-gamma )/ tumor necrosis factor-alpha ( proteinTNF-alpha ) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells , and compared it with the basis of this induction by lipopolysaccharide ( LPS ). |
| 0.8708 | 1.0000 | 1.0000 | We investigated the molecular basis of the synergistic induction by proteininterferon-gamma ( IFN-gamma )/ tumor necrosis factor-alpha ( TNF-alpha ) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells , and compared it with the basis of this induction by lipopolysaccharide ( LPS ). |
| 1.7589 | 10.8268 | 10.5871 | We investigated the molecular basis of the synergistic induction by interferon-gamma ( IFN-gamma )/ tumor necrosis factor-alpha ( TNF-alpha ) of human interleukin-6 (IL-6) gene in cell_lineTHP-1 monocytic cells , and compared it with the basis of this induction by lipopolysaccharide ( LPS ). |
| 0.6737 | 1.0000 | 0.9994 | We investigated the molecular basis of the synergistic induction by interferon-gamma ( IFN-gamma )/ tumor necrosis factor-alpha ( TNF-alpha ) of human interleukin-6 (IL-6) gene in THP-1 cell_typemonocytic cells , and compared it with the basis of this induction by lipopolysaccharide ( LPS ). |
| We investigated the molecular basis of the synergistic induction by interferon-gamma ( IFN-gamma )/ tumor necrosis factor-alpha ( TNF-alpha ) of human interleukin-6 (IL-6) gene in cell_typeTHP-1 monocytic cells , and compared it with the basis of this induction by lipopolysaccharide ( LPS ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3539 | 20.8270 | 1.0000 | Functional studies with DNAIL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or TNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation . |
| 0.9157 | 1.0000 | 1.0000 | Functional studies with IL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or proteinTNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation . |
| 0.8845 | 1.0000 | 1.0000 | Functional studies with IL-6 promoter demonstrated that three regions are the targets of the proteinIFN-gamma and/or TNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation . |
| 2.2726 | 20.9912 | 0.9935 | Functional studies with proteinIL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or TNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6344 | 10.1561 | 1.0000 | The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or proteinTNF-alpha ; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone. |
| 1.5526 | 10.4065 | 1.0000 | The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha ; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by proteinIFN-gamma alone. |
| 0.9300 | 1.0000 | 1.0000 | The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha ; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and proteinTNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone. |
| 0.8823 | 1.0000 | 1.0000 | The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha ; 2) an element located between -181 and -73, which appeared to regulate the response to proteinIFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone. |
| 1.1197 | 10.9331 | 0.9999 | The three regions concerned are: 1) a region between DNA-73 and -36, which is the minimal element inducible by LPS or TNF-alpha ; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone. |
| 0.7396 | 0.9999 | 1.0000 | The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha ; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of DNA-224, which was inducible by IFN-gamma alone. |
| The three regions concerned are: 1) a region between -73 and -36, which is the DNAminimal element inducible by LPS or TNF-alpha ; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone. | |||
| The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha ; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a DNAdistal element upstream of -224, which was inducible by IFN-gamma alone. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4073 | 20.1958 | 10.5572 | LPS signaling was found to involve proteinNF kappa B activation by the p50/p65 heterodimers . |
| 1.3642 | 10.8479 | 0.9999 | LPS signaling was found to involve NF kappa B activation by the proteinp50/p65 heterodimers . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5588 | 20.6994 | 10.7371 | Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the DNAretinoblastoma control element present in the IL-6 promoter . |
| 2.7592 | 10.9276 | 10.6051 | Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and proteinNF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter . |
| 2.0969 | 20.2017 | 0.9999 | Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the DNAIL-6 promoter . |
| 2.0544 | 20.1127 | 1.0000 | Synergistic induction of the DNAIL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter . |
| 2.0105 | 20.4085 | 0.9924 | Synergistic induction of the proteinIL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter . |
| 1.4300 | 10.9693 | 0.9998 | Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in cell_typemonocytic cells , involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter . |
| 0.9767 | 1.0000 | 1.0000 | Synergistic induction of the IL-6 gene by IFN-gamma and proteinTNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter . |
| 0.9537 | 1.0000 | 1.0000 | Synergistic induction of the IL-6 gene by proteinIFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter . |
| 0.8618 | 0.9999 | 1.0000 | Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the proteinIRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter . |
| 0.8408 | 0.9992 | 0.9642 | Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and NF kappa B proteinp65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter . |
| 1.9623 | 20.5697 | 0.9847 | Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the proteinIL-6 promoter . |
| 0.8666 | 0.9794 | 0.9998 | Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and NF kappa B proteinp65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter . |
| Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha , in monocytic cells , involved cooperation between the IRF-1 and proteinNF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1694 | 20.1809 | 10.0860 | This removal occurred by activation of the proteinconstitutive Sp1 factor , whose increased binding activity and phosphorylation were mediated by IFN-gamma . |
| 1.4619 | 10.5958 | 1.0000 | This removal occurred by activation of the constitutive Sp1 factor , whose increased binding activity and phosphorylation were mediated by proteinIFN-gamma . |
| 0.8809 | 1.0000 | 0.9834 | This removal occurred by activation of the constitutive proteinSp1 factor , whose increased binding activity and phosphorylation were mediated by IFN-gamma . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6165 | 10.5602 | 1.0000 | Mutation of Jak3 in a patient with SCID : essential role of proteinJak3 in lymphoid development . |
| 1.5852 | 10.9511 | 1.0000 | Mutation of proteinJak3 in a patient with SCID : essential role of Jak3 in lymphoid development . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5064 | 10.9565 | 1.0000 | Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the common cytokine receptor gamma chain ( gamma c ) gene that encodes a shared, essential component of the receptors of interleukin-2 ( IL-2 ), IL-4 , IL-7 , IL-9 , and proteinIL-15 . |
| 0.9712 | 1.0000 | 1.0000 | Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the common cytokine receptor gamma chain ( gamma c ) gene that encodes a shared, essential component of the receptors of interleukin-2 ( proteinIL-2 ), IL-4 , IL-7 , IL-9 , and IL-15 . |
| 0.9513 | 1.0000 | 1.0000 | Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the common cytokine receptor gamma chain ( gamma c ) gene that encodes a shared, essential component of the receptors of interleukin-2 ( IL-2 ), IL-4 , proteinIL-7 , IL-9 , and IL-15 . |
| 0.9503 | 1.0000 | 1.0000 | Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the common cytokine receptor gamma chain ( gamma c ) gene that encodes a shared, essential component of the receptors of interleukin-2 ( IL-2 ), proteinIL-4 , IL-7 , IL-9 , and IL-15 . |
| 0.9405 | 1.0000 | 1.0000 | Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the common cytokine receptor gamma chain ( gamma c ) gene that encodes a shared, essential component of the receptors of interleukin-2 ( IL-2 ), IL-4 , IL-7 , proteinIL-9 , and IL-15 . |
| 0.8950 | 1.0000 | 1.0000 | Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the common cytokine receptor gamma chain ( gamma c ) gene that encodes a shared, essential component of the receptors of proteininterleukin-2 ( IL-2 ), IL-4 , IL-7 , IL-9 , and IL-15 . |
| 0.7860 | 1.0000 | 0.9217 | Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the common cytokine receptor gamma chain ( proteingamma c ) gene that encodes a shared, essential component of the receptors of interleukin-2 ( IL-2 ), IL-4 , IL-7 , IL-9 , and IL-15 . |
| 6.1389 | 20.4570 | 20.7346 | Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the DNAcommon cytokine receptor gamma chain ( gamma c ) gene that encodes a shared, essential component of the receptors of interleukin-2 ( IL-2 ), IL-4 , IL-7 , IL-9 , and IL-15 . |
| 2.6346 | 40.6945 | 10.4216 | Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the proteincommon cytokine receptor gamma chain ( gamma c ) gene that encodes a shared, essential component of the receptors of interleukin-2 ( IL-2 ), IL-4 , IL-7 , IL-9 , and IL-15 . |
| Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the common proteincytokine receptor gamma chain ( gamma c ) gene that encodes a shared, essential component of the receptors of interleukin-2 ( IL-2 ), IL-4 , IL-7 , IL-9 , and IL-15 . | |||
| Males with X-linked severe combined immunodeficiency ( XSCID ) have defects in the common DNAcytokine receptor gamma chain ( gamma c ) gene that encodes a shared, essential component of the receptors of interleukin-2 ( IL-2 ), IL-4 , IL-7 , IL-9 , and IL-15 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2654 | 20.0620 | 1.0000 | The Janus family tyrosine kinase Jak3 is the only signaling molecule known to be associated with gamma c , so it was hypothesized that defects in proteinJak3 might cause an XSCID -like phenotype . |
| 2.1359 | 20.4090 | 0.9999 | The Janus family tyrosine kinase Jak3 is the only signaling molecule known to be associated with proteingamma c , so it was hypothesized that defects in Jak3 might cause an XSCID -like phenotype . |
| 1.6010 | 10.9002 | 0.9925 | The proteinJanus family tyrosine kinase Jak3 is the only signaling molecule known to be associated with gamma c , so it was hypothesized that defects in Jak3 might cause an XSCID -like phenotype . |
| 0.9771 | 0.9999 | 1.0000 | The Janus family tyrosine kinase proteinJak3 is the only signaling molecule known to be associated with gamma c , so it was hypothesized that defects in Jak3 might cause an XSCID -like phenotype . |
| 1.3152 | 10.1734 | 0.9997 | The Janus family tyrosine kinase Jak3 is the only proteinsignaling molecule known to be associated with gamma c , so it was hypothesized that defects in Jak3 might cause an XSCID -like phenotype . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5262 | 10.2507 | 10.2276 | An cell_lineEpstein-Barr virus ( EBV )-transformed cell line derived from her lymphocytes had normal gamma c expression but lacked Jak3 protein and had greatly diminished Jak3 messenger RNA . |
| 2.4424 | 30.6626 | 10.9273 | An Epstein-Barr virus ( EBV )-transformed cell line derived from her lymphocytes had normal gamma c expression but lacked Jak3 protein and had greatly diminished RNAJak3 messenger RNA . |
| 1.6320 | 20.7928 | 1.0000 | An Epstein-Barr virus ( EBV )-transformed cell line derived from her lymphocytes had normal gamma c expression but lacked proteinJak3 protein and had greatly diminished Jak3 messenger RNA . |
| 1.1686 | 10.9495 | 0.9999 | An Epstein-Barr virus ( EBV )-transformed cell line derived from her lymphocytes had normal proteingamma c expression but lacked Jak3 protein and had greatly diminished Jak3 messenger RNA . |
| 1.1089 | 20.4258 | 0.9886 | An Epstein-Barr virus ( EBV )-transformed cell line derived from her lymphocytes had normal gamma c expression but lacked proteinJak3 protein and had greatly diminished Jak3 messenger RNA . |
| 0.7927 | 0.9999 | 0.9999 | An Epstein-Barr virus ( EBV )-transformed cell line derived from her cell_typelymphocytes had normal gamma c expression but lacked Jak3 protein and had greatly diminished Jak3 messenger RNA . |
| An Epstein-Barr virus ( EBV )-transformed cell line derived from her lymphocytes had normal gamma c expression but lacked Jak3 protein and had greatly diminished proteinJak3 messenger RNA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4314 | 30.2045 | 10.7056 | Sequencing revealed a different mutation on each allele: a single nucleotide insertion resulting in a frame shift and premature termination in the DNAJak3 JH4 domain and a nonsense mutation in the Jak3 JH2 domain . |
| 3.6976 | 30.2136 | 10.9476 | Sequencing revealed a different mutation on each allele: a single nucleotide insertion resulting in a frame shift and premature termination in the Jak3 JH4 domain and a nonsense mutation in the DNAJak3 JH2 domain . |
| 3.5455 | 20.8213 | 10.5987 | Sequencing revealed a different mutation on each allele: a DNAsingle nucleotide insertion resulting in a frame shift and premature termination in the Jak3 JH4 domain and a nonsense mutation in the Jak3 JH2 domain . |
| Sequencing revealed a different mutation on each allele: a single nucleotide insertion resulting in a frame shift and premature termination in the Jak3 JH4 domain and a nonsense mutation in the proteinJak3 JH2 domain . | |||
| Sequencing revealed a different mutation on each allele: a single nucleotide insertion resulting in a frame shift and premature termination in the proteinJak3 JH4 domain and a nonsense mutation in the Jak3 JH2 domain . | |||
| Sequencing revealed a different mutation on each allele: a single nucleotide insertion resulting in a frame shift and premature termination in the proteinJak3 JH4 domain and a nonsense mutation in the Jak3 JH2 domain . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.9598 | 30.0911 | 10.8405 | The lack of Jak3 expression correlated with impaired B cell signaling , as demonstrated by the inability of IL-4 to activate Stat6 in the cell_lineEBV -transformed cell line from the patient. These observations indicate that the functions of gamma c are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling. |
| 2.4006 | 20.2791 | 1.0000 | The lack of proteinJak3 expression correlated with impaired B cell signaling , as demonstrated by the inability of IL-4 to activate Stat6 in the EBV -transformed cell line from the patient. These observations indicate that the functions of gamma c are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling. |
| 2.3661 | 20.9761 | 0.9999 | The lack of Jak3 expression correlated with impaired B cell signaling , as demonstrated by the inability of IL-4 to activate Stat6 in the EBV -transformed cell line from the patient. These observations indicate that the functions of proteingamma c are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling. |
| 1.7087 | 10.3122 | 1.0000 | The lack of Jak3 expression correlated with impaired B cell signaling , as demonstrated by the inability of proteinIL-4 to activate Stat6 in the EBV -transformed cell line from the patient. These observations indicate that the functions of gamma c are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling. |
| 1.6784 | 10.6784 | 1.0000 | The lack of Jak3 expression correlated with impaired B cell signaling , as demonstrated by the inability of IL-4 to activate proteinStat6 in the EBV -transformed cell line from the patient. These observations indicate that the functions of gamma c are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling. |
| 1.6134 | 10.7899 | 1.0000 | The lack of Jak3 expression correlated with impaired B cell signaling , as demonstrated by the inability of IL-4 to activate Stat6 in the EBV -transformed cell line from the patient. These observations indicate that the functions of gamma c are dependent on proteinJak3 and that Jak3 is essential for lymphoid development and signaling. |
| 0.8820 | 1.0000 | 1.0000 | The lack of Jak3 expression correlated with impaired B cell signaling , as demonstrated by the inability of IL-4 to activate Stat6 in the EBV -transformed cell line from the patient. These observations indicate that the functions of gamma c are dependent on Jak3 and that proteinJak3 is essential for lymphoid development and signaling. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.1908 | 40.1420 | 20.6059 | Constitutive overexpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by proteinhuman T-cell lymphotropic virus type 1 Tax . |
| 2.7016 | 20.3588 | 10.0913 | Constitutive overexpression of the L-selectin gene in fresh cell_typeleukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax . |
| 1.8549 | 20.9114 | 1.0000 | Constitutive overexpression of the DNAL-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax . |
| Constitutive overexpression of the proteinL-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9644 | 1.0000 | 1.0000 | proteinL-selectin is an adhesion molecule of the selectin family that mediates the initial step of leukocyte adhesion to vascular endothelium . |
| 2.2366 | 20.2749 | 1.0000 | L-selectin is an proteinadhesion molecule of the selectin family that mediates the initial step of leukocyte adhesion to vascular endothelium . |
| 2.2103 | 20.0911 | 1.0000 | L-selectin is an adhesion molecule of the proteinselectin family that mediates the initial step of leukocyte adhesion to vascular endothelium . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3328 | 20.4157 | 0.9960 | Upon cellular activation , expression of the proteinL-selectin gene is downregulated at both the protein and mRNA levels . |
| 2.2947 | 20.4238 | 1.0000 | Upon cellular activation , expression of the DNAL-selectin gene is downregulated at both the protein and mRNA levels . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.2065 | 20.9198 | 30.9060 | To understand the mechanism of leukemic cell infiltration into organs , we studied the expression and regulation of L-selectin mRNA in fresh leukemic cells of adult T-cell leukemia ( ATL ) patients and investigated the response of the L-selectin promoter to proteinhuman T-cell lymphotropic virus type 1 ( HTLV-1 ) Tax , which is a viral transcriptional transactivator . |
| 2.2982 | 20.2936 | 1.0000 | To understand the mechanism of leukemic cell infiltration into organs , we studied the expression and regulation of RNAL-selectin mRNA in fresh leukemic cells of adult T-cell leukemia ( ATL ) patients and investigated the response of the L-selectin promoter to human T-cell lymphotropic virus type 1 ( HTLV-1 ) Tax , which is a viral transcriptional transactivator . |
| 2.2585 | 10.5868 | 10.6430 | To understand the mechanism of leukemic cell infiltration into organs , we studied the expression and regulation of L-selectin mRNA in fresh cell_typeleukemic cells of adult T-cell leukemia ( ATL ) patients and investigated the response of the L-selectin promoter to human T-cell lymphotropic virus type 1 ( HTLV-1 ) Tax , which is a viral transcriptional transactivator . |
| 1.9608 | 20.5985 | 0.9997 | To understand the mechanism of leukemic cell infiltration into organs , we studied the expression and regulation of L-selectin mRNA in fresh leukemic cells of adult T-cell leukemia ( ATL ) patients and investigated the response of the DNAL-selectin promoter to human T-cell lymphotropic virus type 1 ( HTLV-1 ) Tax , which is a viral transcriptional transactivator . |
| 1.9458 | 20.6989 | 0.9910 | To understand the mechanism of leukemic cell infiltration into organs , we studied the expression and regulation of proteinL-selectin mRNA in fresh leukemic cells of adult T-cell leukemia ( ATL ) patients and investigated the response of the L-selectin promoter to human T-cell lymphotropic virus type 1 ( HTLV-1 ) Tax , which is a viral transcriptional transactivator . |
| 1.3509 | 20.4339 | 0.9625 | To understand the mechanism of leukemic cell infiltration into organs , we studied the expression and regulation of L-selectin mRNA in fresh leukemic cells of adult T-cell leukemia ( ATL ) patients and investigated the response of the proteinL-selectin promoter to human T-cell lymphotropic virus type 1 ( HTLV-1 ) Tax , which is a viral transcriptional transactivator . |
| 1.3026 | 10.0761 | 0.9998 | To understand the mechanism of cell_typeleukemic cell infiltration into organs , we studied the expression and regulation of L-selectin mRNA in fresh leukemic cells of adult T-cell leukemia ( ATL ) patients and investigated the response of the L-selectin promoter to human T-cell lymphotropic virus type 1 ( HTLV-1 ) Tax , which is a viral transcriptional transactivator . |
| 0.5622 | 0.9957 | 0.9990 | To understand the mechanism of leukemic cell infiltration into organs , we studied the expression and regulation of L-selectin mRNA in fresh leukemic cells of adult T-cell leukemia ( ATL ) patients and investigated the response of the L-selectin promoter to human T-cell lymphotropic virus type 1 ( HTLV-1 ) Tax , which is a proteinviral transcriptional transactivator . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6662 | 10.1234 | 1.0000 | Flow cytometry showed that proteinL-selectin was expressed on fresh ATL cells along with other activation antigens . |
| 1.3650 | 10.9843 | 0.9999 | Flow cytometry showed that L-selectin was expressed on fresh ATL cells along with other proteinactivation antigens . |
| Flow cytometry showed that L-selectin was expressed on fresh cell_lineATL cells along with other activation antigens . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6596 | 10.9462 | 1.0000 | Northern blot analysis showed that ATL cells overexpressed that RNAL-selectin mRNA and that the level was aberrantly upregulated after PMA stimulation . |
| 1.5838 | 10.9582 | 0.9999 | Northern blot analysis showed that cell_lineATL cells overexpressed that L-selectin mRNA and that the level was aberrantly upregulated after PMA stimulation . |
| 1.4236 | 10.8723 | 0.9939 | Northern blot analysis showed that ATL cells overexpressed that proteinL-selectin mRNA and that the level was aberrantly upregulated after PMA stimulation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4953 | 20.5486 | 1.0000 | Studies using in situ hybridization showed expression of the RNAL-selectin mRNA in the infiltrating leukemic cells in the liver of two ATL patients . |
| 2.0134 | 20.6820 | 0.9885 | Studies using in situ hybridization showed expression of the proteinL-selectin mRNA in the infiltrating leukemic cells in the liver of two ATL patients . |
| 1.0483 | 1.0000 | 10.3702 | Studies using in situ hybridization showed expression of the L-selectin mRNA in the infiltrating cell_typeleukemic cells in the liver of two ATL patients . |
| 4.5376 | 20.2887 | 10.7338 | Studies using in situ hybridization showed expression of the L-selectin mRNA in the cell_typeinfiltrating leukemic cells in the liver of two ATL patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8304 | 20.0701 | 10.8579 | Intravenous injection of a cell_linerat T-cell line that overexpresses L-selectin showed increased organ infiltration . |
| 1.6117 | 10.5333 | 1.0000 | Intravenous injection of a rat T-cell line that overexpresses proteinL-selectin showed increased organ infiltration . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7328 | 10.5816 | 1.0000 | The induction of proteinTax expression in JPX9 cells resulted in about a twofold increase in the mRNA expression levels compared with the basal level . |
| 1.6295 | 10.9699 | 0.9999 | The induction of Tax expression in cell_lineJPX9 cells resulted in about a twofold increase in the mRNA expression levels compared with the basal level . |
| 1.5137 | 10.0010 | 1.0000 | The induction of Tax expression in JPX9 cells resulted in about a twofold increase in the RNAmRNA expression levels compared with the basal level . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1957 | 20.6145 | 0.9999 | Chloramphenicol acetyltransferase ( CAT ) assay after transient cotransfection showed about a fivefold transactivation of the DNAL-selectin promoter by Tax . |
| 0.9709 | 1.0000 | 1.0000 | Chloramphenicol acetyltransferase ( proteinCAT ) assay after transient cotransfection showed about a fivefold transactivation of the L-selectin promoter by Tax . |
| 0.8824 | 0.9995 | 1.0000 | proteinChloramphenicol acetyltransferase ( CAT ) assay after transient cotransfection showed about a fivefold transactivation of the L-selectin promoter by Tax . |
| 0.8584 | 1.0000 | 1.0000 | Chloramphenicol acetyltransferase ( CAT ) assay after transient cotransfection showed about a fivefold transactivation of the L-selectin promoter by proteinTax . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9576 | 1.0000 | 1.0000 | The serum level of the shed form of proteinL-selectin was significantly increased in ATL patients (mean +/- SD, 4,215.4 +/- 4,111 ng/mL) compared with those of asymptomatic carriers and healthy blood donors (mean +/- SD, 1,148.0 +/- 269.0 ng/mL and 991.9 +/- 224 ng/mL, respectively). |
| 2.3241 | 20.6272 | 1.0000 | The serum level of the proteinshed form of L-selectin was significantly increased in ATL patients (mean +/- SD, 4,215.4 +/- 4,111 ng/mL) compared with those of asymptomatic carriers and healthy blood donors (mean +/- SD, 1,148.0 +/- 269.0 ng/mL and 991.9 +/- 224 ng/mL, respectively). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1607 | 20.0722 | 0.9943 | These results indicated that ATL cells constitutively overexpress the proteinL-selectin gene that can be transactivated by HTLV-1 Tax . |
| 1.5382 | 10.8679 | 0.9999 | These results indicated that cell_lineATL cells constitutively overexpress the L-selectin gene that can be transactivated by HTLV-1 Tax . |
| 1.4835 | 10.9032 | 1.0000 | These results indicated that ATL cells constitutively overexpress the DNAL-selectin gene that can be transactivated by HTLV-1 Tax . |
| 1.4919 | 10.8181 | 0.9999 | These results indicated that ATL cells constitutively overexpress the L-selectin gene that can be transactivated by proteinHTLV-1 Tax . |
| These results indicated that ATL cells constitutively overexpress the L-selectin gene that can be transactivated by HTLV-1 proteinTax . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4188 | 20.2102 | 1.0000 | The overexpression of L-selectin , as well as of inflammatory cytokines , by ATL cells may provide a basis for cell_lineATL cells to attach the vascular endothelium , leading to transmigration and organ infitration . |
| 2.3677 | 20.6628 | 1.0000 | The overexpression of L-selectin , as well as of proteininflammatory cytokines , by ATL cells may provide a basis for ATL cells to attach the vascular endothelium , leading to transmigration and organ infitration . |
| 1.7573 | 10.2698 | 1.0000 | The overexpression of proteinL-selectin , as well as of inflammatory cytokines , by ATL cells may provide a basis for ATL cells to attach the vascular endothelium , leading to transmigration and organ infitration . |
| 1.6210 | 10.7793 | 1.0000 | The overexpression of L-selectin , as well as of inflammatory cytokines , by cell_lineATL cells may provide a basis for ATL cells to attach the vascular endothelium , leading to transmigration and organ infitration . |
| 0.6780 | 1.0000 | 1.0000 | The overexpression of L-selectin , as well as of inflammatory proteincytokines , by ATL cells may provide a basis for ATL cells to attach the vascular endothelium , leading to transmigration and organ infitration . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0645 | 20.7991 | 10.1435 | Human herpesvirus 6 variant A , but not variant B , infects EBV -positive B lymphoid cells , activating the DNAlatent EBV genome through a BZLF-1 -dependent mechanism . |
| 0.8854 | 1.0000 | 1.0000 | Human herpesvirus 6 variant A , but not variant B , infects EBV -positive B lymphoid cells , activating the latent EBV genome through a proteinBZLF-1 -dependent mechanism . |
| 5.7125 | 30.0709 | 10.7223 | Human herpesvirus 6 variant A , but not variant B , infects cell_typeEBV -positive B lymphoid cells , activating the latent EBV genome through a BZLF-1 -dependent mechanism . |
| Human herpesvirus 6 variant A , but not variant B , infects cell_lineEBV -positive B lymphoid cells , activating the latent EBV genome through a BZLF-1 -dependent mechanism . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.1494 | 20.8285 | 20.3751 | Human herpesvirus 6 , a predominantly T lymphotropic virus , has been recently shown to infect some cell_lineEBV -positive B cell lines , and to induce in them the activation of the EBV lytic cycle . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9662 | 20.6674 | 10.6223 | Here we have confirmed and extended such observations, showing that (1) this phenomenon is restricted to the variant A of HHV-6 : in fact two isolates belonging to the HHV-6 variant B ( BA92 and Z29 ) were neither able to infect any cell_lineB cell line , independently of the EBV status , nor to induce the EBV genome expression . |
| 2.9328 | 20.7245 | 10.4403 | Here we have confirmed and extended such observations, showing that (1) this phenomenon is restricted to the variant A of HHV-6 : in fact two isolates belonging to the cell_lineHHV-6 variant B ( BA92 and Z29 ) were neither able to infect any B cell line , independently of the EBV status , nor to induce the EBV genome expression . |
| 2.3028 | 20.9205 | 1.0000 | Here we have confirmed and extended such observations, showing that (1) this phenomenon is restricted to the variant A of HHV-6 : in fact two isolates belonging to the HHV-6 variant B ( BA92 and Z29 ) were neither able to infect any B cell line , independently of the EBV status , nor to induce the DNAEBV genome expression . |
| 0.9595 | 1.0000 | 1.0000 | Here we have confirmed and extended such observations, showing that (1) this phenomenon is restricted to the variant A of HHV-6 : in fact two isolates belonging to the HHV-6 variant B ( BA92 and cell_lineZ29 ) were neither able to infect any B cell line , independently of the EBV status , nor to induce the EBV genome expression . |
| 0.9544 | 1.0000 | 1.0000 | Here we have confirmed and extended such observations, showing that (1) this phenomenon is restricted to the variant A of HHV-6 : in fact two isolates belonging to the HHV-6 variant B ( cell_lineBA92 and Z29 ) were neither able to infect any B cell line , independently of the EBV status , nor to induce the EBV genome expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5003 | 20.2823 | 1.0000 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these DNApromoters . |
| 2.3688 | 30.1687 | 1.0000 | The only exception is represented by the cell_lineP3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 2.3097 | 20.6567 | 0.9999 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of cell_typeinfectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 2.2745 | 30.9205 | 0.9998 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the cell_lineB cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 2.2343 | 20.4695 | 1.0000 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of proteinEBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 2.1490 | 20.3573 | 1.0000 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the DNAEBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 1.4524 | 20.4528 | 0.9999 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the DNApromoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 0.9700 | 1.0000 | 1.0000 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and DNABMRF1 , show a strong transactivation of these promoters . |
| 0.9547 | 0.9999 | 0.9998 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes DNABZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 0.7765 | 1.0000 | 1.0000 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with DNAplasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 4.1746 | 30.8632 | 10.2002 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) cell_typeHHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 1.4773 | 0.9999 | 10.0617 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected cell_typeT cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 1.4164 | 10.9827 | 1.0000 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the DNAbinding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| 0.7218 | 0.9977 | 0.9820 | The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) HHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the DNAEBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . |
| The only exception is represented by the P3HR1 cells , in which, however, the infection by the variant B does not determine induction of EBV antigens ; (2) the presence of the EBV genome contributes to the susceptibility of the B cell lines to HHV-6 infection , increasing the binding sites and the percentage of infectable cells , as detected by immunoelectron microscopy ; and (3) cell_lineHHV-6 infected T cells , transfected with plasmids bearing the promoter regions of the EBV early genes BZLF1 and BMRF1 , show a strong transactivation of these promoters . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2534 | 20.7181 | 10.8398 | Evidence for normal RNAvitamin D receptor messenger ribonucleic acid and genotype in absorptive hypercalciuria . |
| 3.0763 | 20.9367 | 10.5744 | Evidence for normal proteinvitamin D receptor messenger ribonucleic acid and genotype in absorptive hypercalciuria . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.9832 | 30.9958 | 20.6431 | Inasmuch as these features implicate enhanced calcitriol action in gut and bone , we analyzed the DNAvitamin D receptor ( VDR ) gene to ascertain whether an abnormality of this gene marks patients with intestinal hyperabsorption of calcium . |
| 4.1264 | 30.9922 | 10.9751 | Inasmuch as these features implicate enhanced calcitriol action in gut and bone , we analyzed the proteinvitamin D receptor ( VDR ) gene to ascertain whether an abnormality of this gene marks patients with intestinal hyperabsorption of calcium . |
| 0.9375 | 1.0000 | 0.9891 | Inasmuch as these features implicate enhanced calcitriol action in gut and bone , we analyzed the vitamin D receptor ( proteinVDR ) gene to ascertain whether an abnormality of this gene marks patients with intestinal hyperabsorption of calcium . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8317 | 30.1798 | 10.7238 | We have compared the frequency of a DNArestriction fragment length polymorphism ( Bsm I ) associated with different alleles of the VDR gene in a group of 33 well characterized absorptive hypercalciuric patients and a group of 36 normal race- and age-matched control subjects . |
| 1.5929 | 10.5890 | 1.0000 | We have compared the frequency of a restriction fragment length polymorphism ( Bsm I ) associated with different alleles of the DNAVDR gene in a group of 33 well characterized absorptive hypercalciuric patients and a group of 36 normal race- and age-matched control subjects . |
| 0.8491 | 0.9993 | 1.0000 | We have compared the frequency of a restriction fragment length polymorphism ( DNABsm I ) associated with different alleles of the VDR gene in a group of 33 well characterized absorptive hypercalciuric patients and a group of 36 normal race- and age-matched control subjects . |
| 0.6386 | 0.9999 | 1.0000 | We have compared the frequency of a restriction fragment length polymorphism ( Bsm I ) associated with different DNAalleles of the VDR gene in a group of 33 well characterized absorptive hypercalciuric patients and a group of 36 normal race- and age-matched control subjects . |
| We have compared the frequency of a restriction fragment length polymorphism ( Bsm I ) associated with different alleles of the proteinVDR gene in a group of 33 well characterized absorptive hypercalciuric patients and a group of 36 normal race- and age-matched control subjects . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0649 | 20.2425 | 0.9890 | There was no difference between the distribution of the proteinVDR alleles in the patient population when compared with the normal population . |
| 2.3929 | 20.1938 | 1.0000 | There was no difference between the distribution of the DNAVDR alleles in the patient population when compared with the normal population . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6893 | 10.5302 | 10.3432 | The coding region of RNAVDR messenger RNA was also normal, as determined by both DNA sequence analysis and chemical mismatch cleavage analysis of copy DNA from 11 index absorptive hypercalciuric patients . |
| 1.4116 | 10.7424 | 0.9960 | The coding region of proteinVDR messenger RNA was also normal, as determined by both DNA sequence analysis and chemical mismatch cleavage analysis of copy DNA from 11 index absorptive hypercalciuric patients . |
| 1.4099 | 10.2671 | 1.0000 | The coding region of VDR messenger RNA was also normal, as determined by both DNADNA sequence analysis and chemical mismatch cleavage analysis of copy DNA from 11 index absorptive hypercalciuric patients . |
| 2.2789 | 20.0983 | 1.0000 | The coding region of VDR messenger RNA was also normal, as determined by both DNA sequence analysis and chemical mismatch cleavage analysis of DNAcopy DNA from 11 index absorptive hypercalciuric patients . |
| 1.5458 | 10.5113 | 0.9999 | The DNAcoding region of VDR messenger RNA was also normal, as determined by both DNA sequence analysis and chemical mismatch cleavage analysis of copy DNA from 11 index absorptive hypercalciuric patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9358 | 1.0000 | 1.0000 | On the basis of these results, we propose that the enhanced intestinal calcium absorption invariably seen in absorptive hypercalciuria and attendant symptoms of this disorder are not attributable to mutations of the proteinVDR and are not linked to a common VDR genotype . |
| 0.9059 | 1.0000 | 1.0000 | On the basis of these results, we propose that the enhanced intestinal calcium absorption invariably seen in absorptive hypercalciuria and attendant symptoms of this disorder are not attributable to mutations of the VDR and are not linked to a common proteinVDR genotype . |
| On the basis of these results, we propose that the enhanced intestinal calcium absorption invariably seen in absorptive hypercalciuria and attendant symptoms of this disorder are not attributable to mutations of the VDR and are not linked to a common DNAVDR genotype . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1590 | 30.9401 | 10.5130 | Transcriptional regulation of the gene encoding the proteinhuman C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha -responsive elements . |
| 4.4261 | 30.5556 | 10.8921 | Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its DNAtumor necrosis factor-alpha -responsive elements . |
| 2.5211 | 30.6375 | 10.8609 | Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its proteintumor necrosis factor-alpha -responsive elements . |
| 0.9598 | 0.9999 | 1.0000 | Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor proteinAIM/CD69 and functional characterization of its tumor necrosis factor-alpha -responsive elements . |
| Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM/CD69 and functional characterization of its tumor necrosis factor-alpha -responsive DNAelements . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3232 | 20.9237 | 10.8769 | The human activation antigen CD69 is a member of the proteinC-type animal lectin superfamily that functions as a signal-transmitting receptor . |
| 1.8710 | 20.6477 | 0.9997 | The human activation antigen CD69 is a member of the C-type animal lectin superfamily that functions as a proteinsignal-transmitting receptor . |
| 0.8635 | 0.9997 | 1.0000 | The human activation antigen proteinCD69 is a member of the C-type animal lectin superfamily that functions as a signal-transmitting receptor . |
| 3.7879 | 10.9145 | 20.5229 | The proteinhuman activation antigen CD69 is a member of the C-type animal lectin superfamily that functions as a signal-transmitting receptor . |
| The proteinhuman activation antigen CD69 is a member of the C-type animal lectin superfamily that functions as a signal-transmitting receptor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4923 | 20.8110 | 1.0000 | Although the expression of CD69 can be induced in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is mainly expressed by cell_typeT- lymphocytes located in the inflammatory infiltrates of several human diseases . |
| 2.4827 | 20.2957 | 1.0000 | Although the expression of proteinCD69 can be induced in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is mainly expressed by T- lymphocytes located in the inflammatory infiltrates of several human diseases . |
| 2.3471 | 20.4548 | 0.9999 | Although the expression of CD69 can be induced in vitro on cells of most cell_typehematopoietic lineages with a wide variety of stimuli, in vivo it is mainly expressed by T- lymphocytes located in the inflammatory infiltrates of several human diseases . |
| 2.2042 | 20.8112 | 0.9588 | Although the expression of CD69 can be induced in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is mainly expressed by cell_typeT- lymphocytes located in the inflammatory infiltrates of several human diseases . |
| Although the expression of CD69 can be induced in vitro on cells of most hematopoietic lineages with a wide variety of stimuli, in vivo it is mainly expressed by T- cell_typelymphocytes located in the inflammatory infiltrates of several human diseases . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3562 | 20.4586 | 0.9999 | To elucidate the mechanisms that regulate the constitutive and inducible expression of CD69 by leukocytes , we isolated the DNApromoter region of the CD69 gene and carried out its functional characterization . |
| 2.2185 | 20.4949 | 0.9944 | To elucidate the mechanisms that regulate the constitutive and inducible expression of CD69 by leukocytes , we isolated the promoter region of the proteinCD69 gene and carried out its functional characterization . |
| 1.6455 | 10.6893 | 1.0000 | To elucidate the mechanisms that regulate the constitutive and inducible expression of proteinCD69 by leukocytes , we isolated the promoter region of the CD69 gene and carried out its functional characterization . |
| 0.9027 | 1.0000 | 1.0000 | To elucidate the mechanisms that regulate the constitutive and inducible expression of CD69 by cell_typeleukocytes , we isolated the promoter region of the CD69 gene and carried out its functional characterization . |
| 2.3379 | 20.1921 | 1.0000 | To elucidate the mechanisms that regulate the constitutive and inducible expression of CD69 by leukocytes , we isolated the promoter region of the DNACD69 gene and carried out its functional characterization . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1131 | 20.3698 | 1.0000 | Sequence analysis of the 5'-flanking region of the DNACD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 2.0551 | 20.8674 | 0.9999 | Sequence analysis of the DNA5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 2.0166 | 20.7401 | 0.9922 | Sequence analysis of the 5'-flanking region of the proteinCD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 1.9781 | 20.7597 | 0.9972 | Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential DNATATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 1.6802 | 10.1245 | 1.0000 | Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors ( proteinNF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 1.4557 | 20.2051 | 10.5954 | Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible proteintranscription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 0.9770 | 1.0000 | 1.0000 | Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors ( NF-kappa B , Egr-1 , proteinAP-1 ), which might mediate the inducible expression of this gene. |
| 0.9758 | 1.0000 | 1.0000 | Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors ( NF-kappa B , proteinEgr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 0.6883 | 0.8680 | 0.9929 | Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element DNA30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 4.3470 | 20.9760 | 10.6215 | Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the DNAmajor transcription initiation site and several putative binding sequences for inducible transcription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 2.1118 | 10.3683 | 10.9534 | Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for proteininducible transcription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 2.0706 | 30.0866 | 10.7146 | Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential DNATATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| 2.0420 | 20.4243 | 0.9998 | Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative DNAbinding sequences for inducible transcription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. |
| Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major DNAtranscription initiation site and several putative binding sequences for inducible transcription factors ( NF-kappa B , Egr-1 , AP-1 ), which might mediate the inducible expression of this gene. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9759 | 20.6856 | 10.7932 | Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the DNAproximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate -inducible transcription of the CD69 gene . |
| 3.1185 | 30.3252 | 10.6817 | Transient expression of DNACD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate -inducible transcription of the CD69 gene . |
| 2.1074 | 20.5600 | 0.9999 | Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate -inducible transcription of the DNACD69 gene . |
| 2.0137 | 20.9798 | 0.9974 | Transient expression of proteinCD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate -inducible transcription of the CD69 gene . |
| 2.0107 | 20.2293 | 0.9999 | Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the DNAcis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate -inducible transcription of the CD69 gene . |
| 1.5749 | 20.7317 | 0.9780 | Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate -inducible transcription of the proteinCD69 gene . |
| 1.4833 | 10.3116 | 0.9997 | Transient expression of CD69 promoter-based reporter gene constructs in cell_lineK562 cells indicated that the proximal promoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate -inducible transcription of the CD69 gene . |
| 3.6776 | 20.4244 | 10.9868 | Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal promoter region spanning positions DNA-78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate -inducible transcription of the CD69 gene . |
| Transient expression of CD69 promoter-based reporter gene constructs in K562 cells indicated that the proximal DNApromoter region spanning positions -78 to +16 contained the cis-acting sequences necessary for basal and phorbol 12-myristate 13-acetate -inducible transcription of the CD69 gene . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9851 | 10.9583 | 10.6296 | Removal of the upstream sequences located between positions DNA-78 and -38 resulted in decreased promoter strength and abolished the response to phorbol 12-myristate 13-acetate. |
| 2.2695 | 20.1204 | 1.0000 | Removal of the DNAupstream sequences located between positions -78 and -38 resulted in decreased promoter strength and abolished the response to phorbol 12-myristate 13-acetate. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7215 | 20.6040 | 10.8992 | We also found that proteintumor necrosis factor-alpha ( TNF-alpha ) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69 . |
| 2.0575 | 20.6608 | 0.9902 | We also found that tumor necrosis factor-alpha ( TNF-alpha ) is capable of inducing the surface expression of the proteinCD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69 . |
| 1.5230 | 10.5987 | 1.0000 | We also found that tumor necrosis factor-alpha ( TNF-alpha ) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of proteinCD69 . |
| 1.5103 | 10.6449 | 1.0000 | We also found that tumor necrosis factor-alpha ( TNF-alpha ) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the proteinCD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69 . |
| 0.9742 | 1.0000 | 1.0000 | We also found that tumor necrosis factor-alpha ( proteinTNF-alpha ) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69 . |
| 2.1760 | 20.0188 | 0.9999 | We also found that tumor necrosis factor-alpha ( TNF-alpha ) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of DNAfusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69 . |
| 2.1754 | 20.0696 | 0.9999 | We also found that tumor necrosis factor-alpha ( TNF-alpha ) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of fusion plasmids that contain DNA5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69 . |
| 2.1422 | 20.1684 | 1.0000 | We also found that tumor necrosis factor-alpha ( TNF-alpha ) is capable of inducing the surface expression of the proteinCD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this cytokine may regulate in vivo the expression of CD69 . |
| 0.8863 | 1.0000 | 1.0000 | We also found that tumor necrosis factor-alpha ( TNF-alpha ) is capable of inducing the surface expression of the CD69 molecule as well as the promoter activity of fusion plasmids that contain 5'-flanking sequences of the CD69 gene, suggesting that this proteincytokine may regulate in vivo the expression of CD69 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3152 | 10.9733 | 10.3065 | Characterization of 5' end of DNAhuman thromboxane receptor gene . |
| 1.5602 | 10.9398 | 10.7542 | Characterization of 5' end of proteinhuman thromboxane receptor gene . |
| 1.1995 | 10.8267 | 0.9993 | Characterization of DNA5' end of human thromboxane receptor gene . |
| Characterization of DNA5' end of human thromboxane receptor gene . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5378 | 20.1055 | 0.9999 | Organizational analysis and mapping of DNAprotein kinase C--responsive elements regulating expression in platelets . |
| 1.4394 | 10.3254 | 0.9999 | Organizational analysis and mapping of protein kinase C--responsive elements regulating expression in cell_typeplatelets . |
| Organizational analysis and mapping of protein kinase C--responsive DNAelements regulating expression in platelets . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7754 | 0.9988 | 10.4490 | proteinPlatelet thromboxane receptors are acutely and reversibly upregulated after acute myocardial infarction . |
| 0.9876 | 0.9999 | 10.2241 | Platelet proteinthromboxane receptors are acutely and reversibly upregulated after acute myocardial infarction . |
| cell_typePlatelet thromboxane receptors are acutely and reversibly upregulated after acute myocardial infarction . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3662 | 20.9601 | 10.6238 | To determine if platelet thromboxane receptors are under transcriptional control , we isolated and characterized DNAhuman genomic DNA clones containing the 5' flanking region of the thromboxane receptor gene . |
| 4.0992 | 30.9031 | 10.5507 | To determine if platelet thromboxane receptors are under transcriptional control , we isolated and characterized human genomic DNA clones containing the DNA5' flanking region of the thromboxane receptor gene . |
| 1.4397 | 20.5348 | 0.9993 | To determine if platelet thromboxane receptors are under transcriptional control , we isolated and characterized human genomic DNA clones containing the 5' flanking region of the DNAthromboxane receptor gene . |
| 0.6028 | 0.9999 | 0.9999 | To determine if platelet proteinthromboxane receptors are under transcriptional control , we isolated and characterized human genomic DNA clones containing the 5' flanking region of the thromboxane receptor gene . |
| 3.6326 | 20.6698 | 10.7402 | To determine if proteinplatelet thromboxane receptors are under transcriptional control , we isolated and characterized human genomic DNA clones containing the 5' flanking region of the thromboxane receptor gene . |
| 0.9832 | 20.4412 | 0.6103 | To determine if platelet thromboxane receptors are under transcriptional control , we isolated and characterized human genomic DNA clones containing the 5' flanking region of the proteinthromboxane receptor gene . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8706 | 30.2481 | 10.4164 | The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the DNA5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA . |
| 2.1175 | 20.8154 | 0.9998 | The exon-intron structure of the 5' portion of the DNAthromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA . |
| 1.8906 | 20.7225 | 0.9999 | The exon-intron structure of the DNA5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA . |
| 1.8372 | 10.9121 | 10.1730 | The DNAexon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA . |
| 0.8165 | 1.0000 | 0.9156 | The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine proteinthromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA . |
| 5.0753 | 30.1318 | 10.6460 | The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel DNAhuman uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA . |
| 3.9972 | 30.2293 | 10.9400 | The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified DNAhuman placental cDNA . |
| 2.0588 | 20.6851 | 10.7753 | The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the DNAmRNA 141 bp further upstream than the previously identified human placental cDNA . |
| The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a DNAnovel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA . | |||
| The exon-intron structure of the 5' portion of the proteinthromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA . | |||
| The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the DNAnucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the previously identified human placental cDNA . | |||
| The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA 141 bp further upstream than the DNApreviously identified human placental cDNA . | |||
| The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the RNAmRNA 141 bp further upstream than the previously identified human placental cDNA . | |||
| The exon-intron structure of the 5' portion of the thromboxane receptor gene was determined initially by comparing the nucleotide sequence of the 5' flanking genomic clone with that of a novel human uterine thromboxane receptor cDNA that extended the mRNA DNA141 bp further upstream than the previously identified human placental cDNA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1008 | 20.8402 | 10.6367 | A major transcription initiation site was located in three human tissues approximately 560 bp upstream from the translation initiation codon and 380 bp upstream from any previously identified DNAtranscription initiation site . |
| 4.0924 | 20.9483 | 10.6414 | A major transcription initiation site was located in three human tissues approximately DNA560 bp upstream from the translation initiation codon and 380 bp upstream from any previously identified transcription initiation site . |
| 3.3397 | 20.2644 | 10.8963 | A major transcription initiation site was located in three human tissues approximately 560 bp upstream from the DNAtranslation initiation codon and 380 bp upstream from any previously identified transcription initiation site . |
| 2.8957 | 10.5802 | 10.5550 | A major transcription initiation site was located in three human tissues approximately 560 bp upstream from the translation initiation codon and DNA380 bp upstream from any previously identified transcription initiation site . |
| 2.6419 | 20.9799 | 10.7751 | A major DNAtranscription initiation site was located in three human tissues approximately 560 bp upstream from the translation initiation codon and 380 bp upstream from any previously identified transcription initiation site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1456 | 20.4246 | 10.5149 | The thromboxane receptor gene has neither a TATA nor a DNACAAT consensus site . |
| 2.3062 | 10.8334 | 10.1722 | The DNAthromboxane receptor gene has neither a TATA nor a CAAT consensus site . |
| 0.5637 | 0.9835 | 0.3199 | The proteinthromboxane receptor gene has neither a TATA nor a CAAT consensus site . |
| The thromboxane receptor gene has neither a DNATATA nor a CAAT consensus site . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1000 | 30.2475 | 10.8183 | Promoter function of the DNA5' flanking region of the thromboxane receptor gene was evaluated by transfection of thromboxane receptor gene promoter/ chloramphenicol acetyltransferase ( CAT ) chimera plasmids into platelet-like K562 cells . |
| 2.9288 | 30.7589 | 10.3037 | Promoter function of the 5' flanking region of the DNAthromboxane receptor gene was evaluated by transfection of thromboxane receptor gene promoter/ chloramphenicol acetyltransferase ( CAT ) chimera plasmids into platelet-like K562 cells . |
| 0.9352 | 1.0000 | 0.9887 | Promoter function of the 5' flanking region of the thromboxane receptor gene was evaluated by transfection of thromboxane receptor gene promoter/ chloramphenicol acetyltransferase ( proteinCAT ) chimera plasmids into platelet-like K562 cells . |
| 0.9002 | 1.0000 | 0.9943 | Promoter function of the 5' flanking region of the thromboxane receptor gene was evaluated by transfection of thromboxane receptor gene promoter/ proteinchloramphenicol acetyltransferase ( CAT ) chimera plasmids into platelet-like K562 cells . |
| 0.7834 | 0.7837 | 0.8292 | Promoter function of the 5' flanking region of the thromboxane receptor gene was evaluated by transfection of DNAthromboxane receptor gene promoter/ chloramphenicol acetyltransferase ( CAT ) chimera plasmids into platelet-like K562 cells . |
| 2.6648 | 20.1245 | 10.2591 | Promoter function of the 5' flanking region of the thromboxane receptor gene was evaluated by transfection of thromboxane receptor gene promoter/ chloramphenicol acetyltransferase ( CAT ) chimera plasmids into cell_lineplatelet-like K562 cells . |
| Promoter function of the 5' flanking region of the thromboxane receptor gene was evaluated by transfection of DNAthromboxane receptor gene promoter/ chloramphenicol acetyltransferase ( CAT ) chimera plasmids into platelet-like K562 cells . | |||
| Promoter function of the 5' flanking region of the proteinthromboxane receptor gene was evaluated by transfection of thromboxane receptor gene promoter/ chloramphenicol acetyltransferase ( CAT ) chimera plasmids into platelet-like K562 cells . | |||
| Promoter function of the 5' flanking region of the thromboxane receptor gene was evaluated by transfection of proteinthromboxane receptor gene promoter/ chloramphenicol acetyltransferase ( CAT ) chimera plasmids into platelet-like K562 cells . | |||
| Promoter function of the 5' flanking region of the thromboxane receptor gene was evaluated by transfection of thromboxane receptor gene promoter/ chloramphenicol acetyltransferase ( CAT ) chimera plasmids into platelet-like cell_lineK562 cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7464 | 10.6142 | 1.0000 | Thromboxane receptor promoter activity , as assessed by proteinCAT expression , was relatively weak but was significantly enhanced by phorbol ester treatment . |
| 0.8974 | 0.9995 | 0.9997 | proteinThromboxane receptor promoter activity , as assessed by CAT expression , was relatively weak but was significantly enhanced by phorbol ester treatment . |
| Thromboxane DNAreceptor promoter activity , as assessed by CAT expression , was relatively weak but was significantly enhanced by phorbol ester treatment . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.1138 | 30.6003 | 20.5690 | Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester -responsive motifs in the thromboxane receptor gene promoter to a cluster of DNAactivator protein-2 ( AP-2 ) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site . |
| 3.6434 | 20.6878 | 10.9715 | Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester -responsive motifs in the thromboxane receptor gene promoter to a cluster of activator protein-2 ( AP-2 ) binding consensus sites located approximately 1.8 kb 5' from the DNAtranscription initiation site . |
| 2.5107 | 30.4161 | 10.3006 | Functional analysis of DNA5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester -responsive motifs in the thromboxane receptor gene promoter to a cluster of activator protein-2 ( AP-2 ) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site . |
| 1.6739 | 20.0291 | 0.8706 | Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester -responsive motifs in the proteinthromboxane receptor gene promoter to a cluster of activator protein-2 ( AP-2 ) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site . |
| 0.9666 | 1.0000 | 0.9980 | Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester -responsive motifs in the thromboxane receptor gene promoter to a cluster of activator protein-2 ( proteinAP-2 ) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site . |
| 5.0725 | 30.0898 | 10.9133 | Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester -responsive motifs in the DNAthromboxane receptor gene promoter to a cluster of activator protein-2 ( AP-2 ) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site . |
| 2.6941 | 20.0297 | 10.6124 | Functional analysis of 5' deletion constructs in cell_linetransfected K562 cells and gel mobility shift localized the major phorbol ester -responsive motifs in the thromboxane receptor gene promoter to a cluster of activator protein-2 ( AP-2 ) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site . |
| 2.5665 | 30.0070 | 10.8440 | Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major DNAphorbol ester -responsive motifs in the thromboxane receptor gene promoter to a cluster of activator protein-2 ( AP-2 ) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site . |
| Functional analysis of 5' deletion constructs in transfected cell_lineK562 cells and gel mobility shift localized the major phorbol ester -responsive motifs in the thromboxane receptor gene promoter to a cluster of activator protein-2 ( AP-2 ) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site . | |||
| Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester -responsive motifs in the thromboxane receptor gene promoter to a cluster of proteinactivator protein-2 ( AP-2 ) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site . | |||
| Functional analysis of 5' deletion constructs in transfected K562 cells and gel mobility shift localized the major phorbol ester -responsive motifs in the DNAthromboxane receptor gene promoter to a cluster of activator protein-2 ( AP-2 ) binding consensus sites located approximately 1.8 kb 5' from the transcription initiation site . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6944 | 20.8287 | 10.9485 | These studies are the first to determine the structure and organization of the 5' end of the thromboxane receptor gene and demonstrate that thromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an proteinAP-2 -like nuclear factor binding to upstream promoter elements . |
| 4.1891 | 30.8986 | 10.8051 | These studies are the first to determine the structure and organization of the 5' end of the thromboxane receptor gene and demonstrate that thromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an AP-2 -like nuclear factor binding to DNAupstream promoter elements . |
| 3.5422 | 20.5917 | 10.7822 | These studies are the first to determine the structure and organization of the 5' end of the thromboxane receptor gene and demonstrate that thromboxane receptor gene expression can be regulated by activation of proteinprotein kinase C via induction of an AP-2 -like nuclear factor binding to upstream promoter elements . |
| 2.2897 | 20.8102 | 0.9998 | These studies are the first to determine the structure and organization of the 5' end of the DNAthromboxane receptor gene and demonstrate that thromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an AP-2 -like nuclear factor binding to upstream promoter elements . |
| 2.0842 | 20.2274 | 0.9999 | These studies are the first to determine the structure and organization of the 5' end of the thromboxane receptor gene and demonstrate that proteinthromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an AP-2 -like nuclear factor binding to upstream promoter elements . |
| 1.5501 | 20.7642 | 0.6077 | These studies are the first to determine the structure and organization of the 5' end of the proteinthromboxane receptor gene and demonstrate that thromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an AP-2 -like nuclear factor binding to upstream promoter elements . |
| 0.7793 | 1.0000 | 0.9990 | These studies are the first to determine the structure and organization of the 5' end of the thromboxane receptor gene and demonstrate that thromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an proteinAP-2 -like nuclear factor binding to upstream promoter elements . |
| 2.0836 | 20.5095 | 0.9999 | These studies are the first to determine the structure and organization of the DNA5' end of the thromboxane receptor gene and demonstrate that thromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an AP-2 -like nuclear factor binding to upstream promoter elements . |
| These studies are the first to determine the structure and organization of the 5' end of the thromboxane receptor gene and demonstrate that DNAthromboxane receptor gene expression can be regulated by activation of protein kinase C via induction of an AP-2 -like nuclear factor binding to upstream promoter elements . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3994 | 20.3164 | 0.9998 | These findings strongly suggest that the mechanism for previously described upregulation of platelet thromboxane receptors after acute myocardial infarction is increased thromboxane receptor gene transcription in cell_typeplatelet-progenitor cells . |
| 2.2278 | 20.5867 | 0.9999 | These findings strongly suggest that the mechanism for previously described upregulation of platelet thromboxane receptors after acute myocardial infarction is increased proteinthromboxane receptor gene transcription in platelet-progenitor cells . |
| 2.1274 | 20.9820 | 0.9999 | These findings strongly suggest that the mechanism for previously described upregulation of proteinplatelet thromboxane receptors after acute myocardial infarction is increased thromboxane receptor gene transcription in platelet-progenitor cells . |
| 1.5726 | 20.6268 | 0.9960 | These findings strongly suggest that the mechanism for previously described upregulation of cell_typeplatelet thromboxane receptors after acute myocardial infarction is increased thromboxane receptor gene transcription in platelet-progenitor cells . |
| 0.7601 | 0.9996 | 0.9999 | These findings strongly suggest that the mechanism for previously described upregulation of platelet proteinthromboxane receptors after acute myocardial infarction is increased thromboxane receptor gene transcription in platelet-progenitor cells . |
| These findings strongly suggest that the mechanism for previously described upregulation of platelet thromboxane receptors after acute myocardial infarction is increased DNAthromboxane receptor gene transcription in platelet-progenitor cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9168 | 0.9996 | 1.0000 | proteinEstrogen receptor concentration and social factors as predictors of natural killer cell activity in early-stage breast cancer patients . |
| 3.6873 | 20.7632 | 10.6405 | Estrogen receptor concentration and social factors as predictors of cell_typenatural killer cell activity in early-stage breast cancer patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6880 | 20.2111 | 1.0000 | Previous work of ours has demonstrated that a significant amount of natural killer (NK) activity variance after surgery in stage I and II breast cancer patients could be accounted for by both the proteinestrogen receptor ( ER ) status of the tumor and by social factors , namely, perceived social support and seeking social support as a general coping strategy . |
| 0.9886 | 1.0000 | 1.0000 | Previous work of ours has demonstrated that a significant amount of natural killer (NK) activity variance after surgery in stage I and II breast cancer patients could be accounted for by both the estrogen receptor ( proteinER ) status of the tumor and by social factors , namely, perceived social support and seeking social support as a general coping strategy . |
| 1.5245 | 20.5689 | 0.9988 | Previous work of ours has demonstrated that a significant amount of cell_typenatural killer (NK) activity variance after surgery in stage I and II breast cancer patients could be accounted for by both the estrogen receptor ( ER ) status of the tumor and by social factors , namely, perceived social support and seeking social support as a general coping strategy . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9614 | 1.0000 | 1.0000 | It was found that the most significant variable predicting NK activity at follow-up was tumor proteinER concentration , with higher NK activity associated with ER -status . |
| 0.9284 | 1.0000 | 1.0000 | It was found that the most significant variable predicting NK activity at follow-up was tumor ER concentration , with higher NK activity associated with proteinER -status . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6149 | 20.7858 | 1.0000 | If, as the literature suggests, NK activity is relevant to breast cancer control , and since ER -tumors have a worse prognosis, we suggest here that perhaps such tumors are resistant to control by NK cells because they lack the ability to attract an accumulation of cell_typeeffector cells to the tumor site , or because blocking factors at the site of the tumor prevent local tumor control at the site of action. |
| 2.6038 | 20.7511 | 1.0000 | If, as the literature suggests, NK activity is relevant to breast cancer control , and since ER -tumors have a worse prognosis, we suggest here that perhaps such tumors are resistant to control by cell_typeNK cells because they lack the ability to attract an accumulation of effector cells to the tumor site , or because blocking factors at the site of the tumor prevent local tumor control at the site of action. |
| 0.6636 | 1.0000 | 1.0000 | If, as the literature suggests, NK activity is relevant to breast cancer control , and since ER -tumors have a worse prognosis, we suggest here that perhaps such tumors are resistant to control by NK cells because they lack the ability to attract an accumulation of effector cells to the tumor site , or because blocking proteinfactors at the site of the tumor prevent local tumor control at the site of action. |
| If, as the literature suggests, NK activity is relevant to breast cancer control , and since proteinER -tumors have a worse prognosis, we suggest here that perhaps such tumors are resistant to control by NK cells because they lack the ability to attract an accumulation of effector cells to the tumor site , or because blocking factors at the site of the tumor prevent local tumor control at the site of action. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1561 | 20.3135 | 10.7457 | Solution structure of the sequence-specific HMG box of the proteinlymphocyte transcriptional activator Sox-4 . |
| 0.9673 | 1.0000 | 0.9999 | Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator proteinSox-4 . |
| 3.2227 | 20.3067 | 10.7378 | Solution structure of the proteinsequence-specific HMG box of the lymphocyte transcriptional activator Sox-4 . |
| Solution structure of the DNAsequence-specific HMG box of the lymphocyte transcriptional activator Sox-4 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.7224 | 10.7033 | 10.9160 | Two groups of proteinHMG box proteins are distinguished. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2138 | 20.3890 | 1.0000 | Proteins in the first group contain multiple HMG boxes , are non-sequence-specific , and recognize structural features as found in DNAcruciform DNA and cross-over DNA . |
| 1.0691 | 10.6448 | 0.9997 | Proteins in the first group contain multiple HMG boxes , are non-sequence-specific , and recognize structural features as found in cruciform DNA and DNAcross-over DNA . |
| 0.6181 | 0.9999 | 0.9999 | Proteins in the first group contain multiple proteinHMG boxes , are non-sequence-specific , and recognize structural features as found in cruciform DNA and cross-over DNA . |
| 3.3565 | 20.8573 | 10.3580 | Proteins in the first group contain proteinmultiple HMG boxes , are non-sequence-specific , and recognize structural features as found in cruciform DNA and cross-over DNA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8101 | 10.9120 | 10.7363 | The abundant proteinchromosomal protein HMG-1 belongs to this subgroup. |
| The abundant chromosomal protein proteinHMG-1 belongs to this subgroup. | |||
| The abundant proteinchromosomal protein HMG-1 belongs to this subgroup. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8672 | 20.1775 | 1.0000 | Proteins in the second group carry a single HMG box with affinity for the DNAminor groove of the heptamer motif AACAAAG or variations thereof. |
| 1.6861 | 20.0583 | 1.0000 | Proteins in the second group carry a single HMG box with affinity for the minor groove of the DNAheptamer motif AACAAAG or variations thereof. |
| 1.5680 | 10.8600 | 1.0000 | Proteins in the second group carry a single proteinHMG box with affinity for the minor groove of the heptamer motif AACAAAG or variations thereof. |
| Proteins in the second group carry a proteinsingle HMG box with affinity for the minor groove of the heptamer motif AACAAAG or variations thereof. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9086 | 1.0000 | 1.0000 | A solution structure for the non-sequence-specific C-terminal HMG box of proteinHMG-1 has recently been proposed. |
| 3.7253 | 20.7450 | 10.9377 | A solution structure for the proteinnon-sequence-specific C-terminal HMG box of HMG-1 has recently been proposed. |
| A solution structure for the non-sequence-specific proteinC-terminal HMG box of HMG-1 has recently been proposed. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3794 | 10.7994 | 0.9991 | Now, we report the solution structure of the sequence-specific HMG-box of the proteinSRY-related protein Sox-4 . |
| 1.3689 | 10.9738 | 0.9999 | Now, we report the solution structure of the proteinsequence-specific HMG-box of the SRY-related protein Sox-4 . |
| 0.9615 | 1.0000 | 1.0000 | Now, we report the solution structure of the sequence-specific HMG-box of the SRY-related protein proteinSox-4 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6449 | 10.8286 | 1.0000 | NMR analysis demonstrated the presence of three proteinalpha-helices ( Val10-Gln22 , Glu30-Leu41 and Phe50-Tyr65 ) connected by loop regions ( Ser23-Ala49 and Leu42-Pro49 ). |
| 1.5358 | 10.9710 | 1.0000 | NMR analysis demonstrated the presence of three alpha-helices ( Val10-Gln22 , Glu30-Leu41 and Phe50-Tyr65 ) connected by proteinloop regions ( Ser23-Ala49 and Leu42-Pro49 ). |
| 0.7587 | 1.0000 | 1.0000 | NMR analysis demonstrated the presence of three alpha-helices ( Val10-Gln22 , Glu30-Leu41 and proteinPhe50-Tyr65 ) connected by loop regions ( Ser23-Ala49 and Leu42-Pro49 ). |
| 0.5840 | 1.0000 | 1.0000 | NMR analysis demonstrated the presence of three alpha-helices ( Val10-Gln22 , Glu30-Leu41 and Phe50-Tyr65 ) connected by loop regions ( proteinSer23-Ala49 and Leu42-Pro49 ). |
| 0.5423 | 0.9999 | 1.0000 | NMR analysis demonstrated the presence of three alpha-helices ( Val10-Gln22 , proteinGlu30-Leu41 and Phe50-Tyr65 ) connected by loop regions ( Ser23-Ala49 and Leu42-Pro49 ). |
| NMR analysis demonstrated the presence of three alpha-helices ( Val10-Gln22 , Glu30-Leu41 and Phe50-Tyr65 ) connected by loop regions ( Ser23-Ala49 and proteinLeu42-Pro49 ). | |||
| NMR analysis demonstrated the presence of three alpha-helices ( proteinVal10-Gln22 , Glu30-Leu41 and Phe50-Tyr65 ) connected by loop regions ( Ser23-Ala49 and Leu42-Pro49 ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3519 | 20.7014 | 0.9999 | Helices I and II are positioned in an antiparallel mode and form one arm of the proteinHMG box . |
| Helices I and II are positioned in an proteinantiparallel mode and form one arm of the HMG box . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9364 | 1.0000 | 1.0000 | proteinHelix III is less rigid, makes an average angle of about 90 degrees with helices I and II , and constitutes the other arm of the molecule. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4279 | 20.1162 | 1.0000 | As in proteinHMG1B , the overall structure of the Sox-4 HMG box is L-shaped and is maintained by a cluster of conserved, mainly aromatic residues . |
| 3.8496 | 20.8832 | 10.3333 | As in HMG1B , the overall structure of the proteinSox-4 HMG box is L-shaped and is maintained by a cluster of conserved, mainly aromatic residues . |
| As in HMG1B , the overall structure of the Sox-4 proteinHMG box is L-shaped and is maintained by a cluster of conserved, mainly aromatic residues . | |||
| As in HMG1B , the overall structure of the proteinSox-4 HMG box is L-shaped and is maintained by a cluster of conserved, mainly aromatic residues . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2468 | 20.0634 | 10.6048 | Nuclear factor-IL6 activates the DNAhuman IL-4 promoter in T cells . |
| 1.3447 | 10.7435 | 0.9993 | Nuclear factor-IL6 activates the human IL-4 promoter in cell_typeT cells . |
| 0.8143 | 0.9980 | 0.9999 | proteinNuclear factor-IL6 activates the human IL-4 promoter in T cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3816 | 30.1346 | 10.6003 | Positive regulatory element I ( PRE-I ) is a strong enhancer element essential for expression of the DNAhuman IL-4 gene . |
| 1.7103 | 20.9956 | 0.9999 | Positive regulatory element I ( PRE-I ) is a strong DNAenhancer element essential for expression of the human IL-4 gene . |
| 1.4327 | 0.9810 | 10.1628 | DNAPositive regulatory element I ( PRE-I ) is a strong enhancer element essential for expression of the human IL-4 gene . |
| 0.9482 | 1.0000 | 1.0000 | Positive regulatory element I ( DNAPRE-I ) is a strong enhancer element essential for expression of the human IL-4 gene . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0930 | 20.3921 | 10.8569 | To identify transcription factors binding to PRE-I , we screened a DNAcDNA expression library from Jurkat T cells and isolated a cDNA encoding nuclear factor (NF)-IL6 (also known as C/EBP beta ). |
| 2.8848 | 10.8842 | 10.9802 | To identify transcription factors binding to PRE-I , we screened a cDNA expression library from cell_lineJurkat T cells and isolated a cDNA encoding nuclear factor (NF)-IL6 (also known as C/EBP beta ). |
| 1.5649 | 10.4846 | 1.0000 | To identify transcription factors binding to DNAPRE-I , we screened a cDNA expression library from Jurkat T cells and isolated a cDNA encoding nuclear factor (NF)-IL6 (also known as C/EBP beta ). |
| 1.3395 | 10.7325 | 1.0000 | To identify proteintranscription factors binding to PRE-I , we screened a cDNA expression library from Jurkat T cells and isolated a cDNA encoding nuclear factor (NF)-IL6 (also known as C/EBP beta ). |
| 1.2559 | 10.8642 | 0.9999 | To identify transcription factors binding to PRE-I , we screened a cDNA expression library from Jurkat T cells and isolated a cDNA encoding nuclear factor (NF)-IL6 (also known as proteinC/EBP beta ). |
| 4.5093 | 20.7126 | 10.8975 | To identify transcription factors binding to PRE-I , we screened a cDNA expression library from Jurkat T cells and isolated a proteincDNA encoding nuclear factor (NF)-IL6 (also known as C/EBP beta ). |
| 1.2439 | 0.9998 | 10.0225 | To identify transcription factors binding to PRE-I , we screened a cDNA expression library from Jurkat T cells and isolated a cDNA encoding proteinnuclear factor (NF)-IL6 (also known as C/EBP beta ). |
| To identify transcription factors binding to PRE-I , we screened a cDNA expression library from Jurkat T cells and isolated a cDNA encoding nuclear factor protein(NF)-IL6 (also known as C/EBP beta ). | |||
| To identify transcription factors binding to PRE-I , we screened a cDNA expression library from Jurkat T cells and isolated a DNAcDNA encoding nuclear factor (NF)-IL6 (also known as C/EBP beta ). | |||
| To identify transcription factors binding to PRE-I , we screened a cDNA expression library from Jurkat T cells and isolated a cDNA encoding proteinnuclear factor (NF)-IL6 (also known as C/EBP beta ). | |||
| To identify transcription factors binding to PRE-I , we screened a cDNA expression library from Jurkat cell_typeT cells and isolated a cDNA encoding nuclear factor (NF)-IL6 (also known as C/EBP beta ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4180 | 20.8097 | 10.7198 | NF-IL6 mRNA was found in human Jurkat T cells and in the mouse Th2 clone D10 , but not in cell_lineTh1 clone 29 . |
| 0.8722 | 0.9953 | 1.0000 | RNANF-IL6 mRNA was found in human Jurkat T cells and in the mouse Th2 clone D10 , but not in Th1 clone 29 . |
| 4.4698 | 20.6832 | 10.8080 | NF-IL6 mRNA was found in human Jurkat T cells and in the cell_linemouse Th2 clone D10 , but not in Th1 clone 29 . |
| 3.4016 | 20.3300 | 10.8206 | NF-IL6 mRNA was found in human cell_lineJurkat T cells and in the mouse Th2 clone D10 , but not in Th1 clone 29 . |
| 0.8995 | 0.9999 | 0.9872 | proteinNF-IL6 mRNA was found in human Jurkat T cells and in the mouse Th2 clone D10 , but not in Th1 clone 29 . |
| NF-IL6 mRNA was found in human Jurkat T cells and in the mouse Th2 clone cell_lineD10 , but not in Th1 clone 29 . | |||
| NF-IL6 mRNA was found in human Jurkat T cells and in the cell_linemouse Th2 clone D10 , but not in Th1 clone 29 . | |||
| NF-IL6 mRNA was found in human Jurkat cell_typeT cells and in the mouse Th2 clone D10 , but not in Th1 clone 29 . | |||
| NF-IL6 mRNA was found in cell_linehuman Jurkat T cells and in the mouse Th2 clone D10 , but not in Th1 clone 29 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5752 | 10.6608 | 1.0000 | rNF-IL6 expressed in bacteria was shown to specifically bind to DNAPRE-I . |
| 0.9801 | 1.0000 | 1.0000 | proteinrNF-IL6 expressed in bacteria was shown to specifically bind to PRE-I . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0887 | 20.0327 | 0.9997 | PRE-I forms multiple DNA-protein complexes with nuclear extracts from cell_lineJurkat cells . |
| 0.9308 | 0.9999 | 1.0000 | DNAPRE-I forms multiple DNA-protein complexes with nuclear extracts from Jurkat cells . |
| 2.6824 | 20.3012 | 10.0478 | PRE-I forms multiple proteinDNA-protein complexes with nuclear extracts from Jurkat cells . |
| PRE-I forms proteinmultiple DNA-protein complexes with nuclear extracts from Jurkat cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8425 | 20.1044 | 10.7776 | Some of these complexes were demonstrated to contain NF-IL6 by using proteinanti- C/EBP beta Abs . |
| 1.4020 | 10.8857 | 1.0000 | Some of these complexes were demonstrated to contain proteinNF-IL6 by using anti- C/EBP beta Abs . |
| 0.6815 | 1.0000 | 0.8547 | Some of these complexes were demonstrated to contain NF-IL6 by using anti- proteinC/EBP beta Abs . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6889 | 20.7842 | 10.9086 | Overexpression of NF-IL6 enhanced expression of the DNAchloramphenicol acetyl transferase reporter gene linked to the PRE-I -thymidine kinase or the human IL-4 promoter more than 10-fold in Jurkat cells . |
| 3.8709 | 40.3262 | 10.4592 | Overexpression of NF-IL6 enhanced expression of the chloramphenicol acetyl transferase reporter gene linked to the proteinPRE-I -thymidine kinase or the human IL-4 promoter more than 10-fold in Jurkat cells . |
| 3.4266 | 20.9725 | 10.7632 | Overexpression of NF-IL6 enhanced expression of the chloramphenicol acetyl transferase reporter gene linked to the PRE-I -thymidine kinase or the DNAhuman IL-4 promoter more than 10-fold in Jurkat cells . |
| 2.7116 | 30.8442 | 10.6369 | Overexpression of NF-IL6 enhanced expression of the proteinchloramphenicol acetyl transferase reporter gene linked to the PRE-I -thymidine kinase or the human IL-4 promoter more than 10-fold in Jurkat cells . |
| 2.0973 | 20.0565 | 1.0000 | Overexpression of proteinNF-IL6 enhanced expression of the chloramphenicol acetyl transferase reporter gene linked to the PRE-I -thymidine kinase or the human IL-4 promoter more than 10-fold in Jurkat cells . |
| 1.2891 | 10.4135 | 0.9991 | Overexpression of NF-IL6 enhanced expression of the chloramphenicol acetyl transferase reporter gene linked to the PRE-I -thymidine kinase or the human IL-4 promoter more than 10-fold in cell_lineJurkat cells . |
| Overexpression of NF-IL6 enhanced expression of the chloramphenicol acetyl transferase reporter gene linked to the PRE-I -thymidine kinase or the proteinhuman IL-4 promoter more than 10-fold in Jurkat cells . | |||
| Overexpression of NF-IL6 enhanced expression of the chloramphenicol acetyl transferase reporter gene linked to the DNAPRE-I -thymidine kinase or the human IL-4 promoter more than 10-fold in Jurkat cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5986 | 20.9490 | 10.8084 | Promoter deletion studies revealed two additional DNANF-IL6 binding sites located at positions -44 to -36 ( C/EBP proximal ) and -87 to -79 ( C/EBP medial ), respectively. |
| 2.0559 | 20.3084 | 0.9957 | Promoter deletion studies revealed two additional proteinNF-IL6 binding sites located at positions -44 to -36 ( C/EBP proximal ) and -87 to -79 ( C/EBP medial ), respectively. |
| 4.1098 | 20.1942 | 10.6972 | Promoter deletion studies revealed two additional NF-IL6 binding sites located at positions DNA-44 to -36 ( C/EBP proximal ) and -87 to -79 ( C/EBP medial ), respectively. |
| 3.4427 | 20.2255 | 10.7239 | Promoter deletion studies revealed two additional NF-IL6 binding sites located at positions -44 to -36 ( C/EBP proximal ) and DNA-87 to -79 ( C/EBP medial ), respectively. |
| 1.5285 | 10.1827 | 0.9999 | Promoter deletion studies revealed two additional NF-IL6 binding sites located at positions -44 to -36 ( C/EBP proximal ) and -87 to -79 ( DNAC/EBP medial ), respectively. |
| 1.5246 | 10.2299 | 0.9999 | Promoter deletion studies revealed two additional NF-IL6 binding sites located at positions -44 to -36 ( DNAC/EBP proximal ) and -87 to -79 ( C/EBP medial ), respectively. |
| Promoter deletion studies revealed two additional NF-IL6 binding sites located at positions -44 to -36 ( proteinC/EBP proximal ) and -87 to -79 ( C/EBP medial ), respectively. | |||
| Promoter deletion studies revealed two additional NF-IL6 binding sites located at positions -44 to -36 ( C/EBP proximal ) and -87 to -79 ( proteinC/EBP medial ), respectively. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4257 | 20.1996 | 0.9999 | Our results demonstrate that NF-IL6 is involved in transcriptional activation of the DNAhuman IL-4 promoter in T cells . |
| 1.5217 | 10.4199 | 0.9995 | Our results demonstrate that NF-IL6 is involved in transcriptional activation of the human IL-4 promoter in cell_typeT cells . |
| 1.5195 | 10.3223 | 1.0000 | Our results demonstrate that proteinNF-IL6 is involved in transcriptional activation of the human IL-4 promoter in T cells . |
| 0.8421 | 1.0000 | 0.9818 | Our results demonstrate that NF-IL6 is involved in transcriptional activation of the human proteinIL-4 promoter in T cells . |
| Our results demonstrate that NF-IL6 is involved in transcriptional activation of the proteinhuman IL-4 promoter in T cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.3886 | 20.7123 | 20.1140 | Identification of an proteinI kappa B alpha-associated protein kinase in a human monocytic cell line and determination of its phosphorylation sites on I kappa B alpha . |
| 4.4077 | 30.4965 | 10.8411 | Identification of an I kappa B alpha-associated protein kinase in a cell_linehuman monocytic cell line and determination of its phosphorylation sites on I kappa B alpha . |
| 2.1700 | 20.6507 | 10.0789 | Identification of an I kappa B alpha-associated protein kinase in a human monocytic cell line and determination of its phosphorylation sites on proteinI kappa B alpha . |
| 1.8636 | 20.2324 | 0.9999 | Identification of an I kappa B alpha-associated protein kinase in a human monocytic cell line and determination of its proteinphosphorylation sites on I kappa B alpha . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4342 | 20.8772 | 10.9274 | Nuclear factor kappa B ( NF-kappa B ) is stored in the cytoplasm as an inactive form through interaction with proteinI kappa B . |
| 1.6679 | 10.5657 | 1.0000 | Nuclear factor kappa B ( proteinNF-kappa B ) is stored in the cytoplasm as an inactive form through interaction with I kappa B . |
| 1.6290 | 0.9967 | 10.3309 | proteinNuclear factor kappa B ( NF-kappa B ) is stored in the cytoplasm as an inactive form through interaction with I kappa B . |
| 2.1313 | 20.0266 | 1.0000 | Nuclear factor kappa B ( NF-kappa B ) is stored in the cytoplasm as an proteininactive form through interaction with I kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7478 | 20.3845 | 20.3963 | Stimulation of cells leads to a rapid phosphorylation of proteinI kappa B alpha , which is presumed to be important for the subsequent degradation . |
| Stimulation of cells leads to a rapid phosphorylation of proteinI kappa B alpha , which is presumed to be important for the subsequent degradation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0130 | 20.7285 | 10.7072 | We have recently reported the establishment of a lipopolysaccharide ( LPS )-dependent cell-free activation system of NF-kappa B in association with the induction of proteinI kappa B alpha phosphorylation . |
| 1.5018 | 10.8983 | 1.0000 | We have recently reported the establishment of a lipopolysaccharide ( LPS )-dependent cell-free activation system of proteinNF-kappa B in association with the induction of I kappa B alpha phosphorylation . |
| We have recently reported the establishment of a lipopolysaccharide ( LPS )-dependent cell-free activation system of NF-kappa B in association with the induction of proteinI kappa B alpha phosphorylation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 8.1812 | 30.8593 | 20.5925 | In this study, we have identified a kinase in cell extracts from the cell_lineLPS -stimulated human monocytic cell line , THP-1 , that specifically binds and phosphorylates I kappa B alpha . |
| 3.7996 | 30.0775 | 10.1045 | In this study, we have identified a kinase in cell extracts from the LPS -stimulated human monocytic cell line , THP-1 , that specifically binds and phosphorylates proteinI kappa B alpha . |
| 0.9259 | 1.0000 | 1.0000 | In this study, we have identified a kinase in cell extracts from the LPS -stimulated human monocytic cell line , cell_lineTHP-1 , that specifically binds and phosphorylates I kappa B alpha . |
| In this study, we have identified a proteinkinase in cell extracts from the LPS -stimulated human monocytic cell line , THP-1 , that specifically binds and phosphorylates I kappa B alpha . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7178 | 20.8206 | 10.9166 | LPS stimulation transiently enhanced the proteinI kappa B alpha -bound kinase activity in THP-1 cells . |
| 2.0920 | 20.4326 | 0.9997 | LPS stimulation transiently enhanced the I kappa B alpha -bound kinase activity in cell_lineTHP-1 cells . |
| LPS stimulation transiently enhanced the proteinI kappa B alpha -bound kinase activity in THP-1 cells . | |||
| LPS stimulation transiently enhanced the I kappa B alpha protein-bound kinase activity in THP-1 cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0315 | 20.0676 | 10.6325 | Mutational analyses of I kappa B alpha and competition experiments with the synthetic peptides identified major phosphorylation sites by the bound kinase as Ser and Thr residues in the C-terminal acidic domain of proteinI kappa B alpha . |
| 2.7959 | 20.9992 | 10.9841 | Mutational analyses of I kappa B alpha and competition experiments with the synthetic peptides identified major phosphorylation sites by the bound kinase as Ser and Thr residues in the proteinC-terminal acidic domain of I kappa B alpha . |
| 0.8667 | 1.0000 | 1.0000 | Mutational analyses of I kappa B alpha and competition experiments with the synthetic peptides identified major phosphorylation sites by the bound proteinkinase as Ser and Thr residues in the C-terminal acidic domain of I kappa B alpha . |
| 5.3226 | 30.0301 | 10.6918 | Mutational analyses of proteinI kappa B alpha and competition experiments with the synthetic peptides identified major phosphorylation sites by the bound kinase as Ser and Thr residues in the C-terminal acidic domain of I kappa B alpha . |
| 3.1633 | 20.4873 | 10.8125 | Mutational analyses of I kappa B alpha and competition experiments with the synthetic peptides identified proteinmajor phosphorylation sites by the bound kinase as Ser and Thr residues in the C-terminal acidic domain of I kappa B alpha . |
| Mutational analyses of I kappa B alpha and competition experiments with the synthetic peptides identified major proteinphosphorylation sites by the bound kinase as Ser and Thr residues in the C-terminal acidic domain of I kappa B alpha . | |||
| Mutational analyses of I kappa B alpha and competition experiments with the synthetic peptides identified major phosphorylation sites by the bound kinase as Ser and Thr residues in the C-terminal acidic domain of proteinI kappa B alpha . | |||
| Mutational analyses of proteinI kappa B alpha and competition experiments with the synthetic peptides identified major phosphorylation sites by the bound kinase as Ser and Thr residues in the C-terminal acidic domain of I kappa B alpha . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7718 | 20.8882 | 10.6058 | Moreover, we show that the peptide , corresponding to the C-terminal acidic domain of I kappa B alpha , blocked the LPS -induced NF-kappa B activation as well as inducible phosphorylation of endogenous proteinI kappa B alpha in a cell-free system using THP-1 cells . |
| 4.2977 | 20.9968 | 10.6173 | Moreover, we show that the peptide , corresponding to the proteinC-terminal acidic domain of I kappa B alpha , blocked the LPS -induced NF-kappa B activation as well as inducible phosphorylation of endogenous I kappa B alpha in a cell-free system using THP-1 cells . |
| 3.3157 | 10.6721 | 10.6274 | Moreover, we show that the peptide , corresponding to the C-terminal acidic domain of proteinI kappa B alpha , blocked the LPS -induced NF-kappa B activation as well as inducible phosphorylation of endogenous I kappa B alpha in a cell-free system using THP-1 cells . |
| 2.1421 | 20.0532 | 0.9997 | Moreover, we show that the peptide , corresponding to the C-terminal acidic domain of I kappa B alpha , blocked the LPS -induced NF-kappa B activation as well as inducible phosphorylation of endogenous I kappa B alpha in a cell-free system using cell_lineTHP-1 cells . |
| 1.4985 | 10.7264 | 1.0000 | Moreover, we show that the peptide , corresponding to the C-terminal acidic domain of I kappa B alpha , blocked the LPS -induced proteinNF-kappa B activation as well as inducible phosphorylation of endogenous I kappa B alpha in a cell-free system using THP-1 cells . |
| Moreover, we show that the peptide , corresponding to the C-terminal acidic domain of proteinI kappa B alpha , blocked the LPS -induced NF-kappa B activation as well as inducible phosphorylation of endogenous I kappa B alpha in a cell-free system using THP-1 cells . | |||
| Moreover, we show that the peptide , corresponding to the C-terminal acidic domain of I kappa B alpha , blocked the LPS -induced NF-kappa B activation as well as inducible phosphorylation of endogenous proteinI kappa B alpha in a cell-free system using THP-1 cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0027 | 20.8759 | 10.9666 | These results suggested that the bound kinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the C-terminal region of proteinI kappa B alpha and subsequent dissociation of the NF-kappa B . I kappa B alpha complex . |
| 3.3613 | 10.9550 | 10.4656 | These results suggested that the bound kinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the C-terminal region of I kappa B alpha and subsequent dissociation of the NF-kappa B . proteinI kappa B alpha complex . |
| 2.1039 | 20.1247 | 0.9999 | These results suggested that the bound kinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the proteinC-terminal region of I kappa B alpha and subsequent dissociation of the NF-kappa B . I kappa B alpha complex . |
| 1.4306 | 10.0238 | 10.8705 | These results suggested that the bound kinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the C-terminal region of I kappa B alpha and subsequent dissociation of the NF-kappa B . proteinI kappa B alpha complex . |
| 1.4102 | 10.4713 | 0.9996 | These results suggested that the bound kinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the C-terminal region of I kappa B alpha and subsequent dissociation of the proteinNF-kappa B . I kappa B alpha complex . |
| 1.2100 | 10.0201 | 1.0000 | These results suggested that the bound proteinkinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the C-terminal region of I kappa B alpha and subsequent dissociation of the NF-kappa B . I kappa B alpha complex . |
| These results suggested that the proteinbound kinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the C-terminal region of I kappa B alpha and subsequent dissociation of the NF-kappa B . I kappa B alpha complex . | |||
| These results suggested that the bound kinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the C-terminal region of proteinI kappa B alpha and subsequent dissociation of the NF-kappa B . I kappa B alpha complex . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6637 | 20.9546 | 10.4964 | Bik , a novel death-inducing protein shares a distinct sequence motif with proteinBcl-2 family proteins and interacts with viral and cellular survival-promoting proteins . |
| 2.0848 | 20.2401 | 0.9999 | Bik , a novel proteindeath-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins . |
| 0.9711 | 1.0000 | 1.0000 | proteinBik , a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins . |
| Bik , a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and proteincellular survival-promoting proteins . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1060 | 20.9933 | 0.9999 | The survival-promoting activity of the Bcl-2 family of proteins appears to be modulated by interactions between various proteincellular proteins . |
| 4.6540 | 30.2105 | 10.8013 | The survival-promoting activity of the proteinBcl-2 family of proteins appears to be modulated by interactions between various cellular proteins . |
| The survival-promoting activity of the proteinBcl-2 family of proteins appears to be modulated by interactions between various cellular proteins . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1504 | 20.9343 | 10.8040 | We have identified a novel cellular protein , Bik , that interacts with the proteincellular survival-promoting proteins , Bcl-2 and Bcl-xL , as well as the viral survival-promoting proteins , Epstein Barr virus -BHRF1 and adenovirus E1B-19 kDa . |
| 4.0278 | 20.6207 | 10.6811 | We have identified a novel cellular protein , Bik , that interacts with the cellular survival-promoting proteins , Bcl-2 and Bcl-xL , as well as the proteinviral survival-promoting proteins , Epstein Barr virus -BHRF1 and adenovirus E1B-19 kDa . |
| 3.6486 | 20.2807 | 10.5188 | We have identified a novel cellular protein , Bik , that interacts with the cellular survival-promoting proteins , Bcl-2 and Bcl-xL , as well as the viral survival-promoting proteins , Epstein Barr virus -BHRF1 and proteinadenovirus E1B-19 kDa . |
| 3.2059 | 10.8608 | 10.9927 | We have identified a novel cellular protein , Bik , that interacts with the cellular survival-promoting proteins , Bcl-2 and Bcl-xL , as well as the viral survival-promoting proteins , proteinEpstein Barr virus -BHRF1 and adenovirus E1B-19 kDa . |
| 1.1361 | 0.9999 | 10.3248 | We have identified a novel proteincellular protein , Bik , that interacts with the cellular survival-promoting proteins , Bcl-2 and Bcl-xL , as well as the viral survival-promoting proteins , Epstein Barr virus -BHRF1 and adenovirus E1B-19 kDa . |
| 0.9674 | 1.0000 | 1.0000 | We have identified a novel cellular protein , Bik , that interacts with the cellular survival-promoting proteins , Bcl-2 and proteinBcl-xL , as well as the viral survival-promoting proteins , Epstein Barr virus -BHRF1 and adenovirus E1B-19 kDa . |
| 0.9661 | 1.0000 | 1.0000 | We have identified a novel cellular protein , Bik , that interacts with the cellular survival-promoting proteins , proteinBcl-2 and Bcl-xL , as well as the viral survival-promoting proteins , Epstein Barr virus -BHRF1 and adenovirus E1B-19 kDa . |
| 0.9280 | 1.0000 | 1.0000 | We have identified a novel cellular protein , proteinBik , that interacts with the cellular survival-promoting proteins , Bcl-2 and Bcl-xL , as well as the viral survival-promoting proteins , Epstein Barr virus -BHRF1 and adenovirus E1B-19 kDa . |
| 3.9732 | 20.8471 | 10.8274 | We have identified a proteinnovel cellular protein , Bik , that interacts with the cellular survival-promoting proteins , Bcl-2 and Bcl-xL , as well as the viral survival-promoting proteins , Epstein Barr virus -BHRF1 and adenovirus E1B-19 kDa . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1223 | 20.1229 | 1.0000 | In transient transfection assays , Bik promotes cell death in a manner similar to the death-promoting members of the proteinBcl-2 family , Bax and Bak . |
| 2.0164 | 20.8209 | 0.9999 | In transient transfection assays , Bik promotes cell death in a manner similar to the proteindeath-promoting members of the Bcl-2 family , Bax and Bak . |
| 1.9245 | 20.3601 | 0.9825 | In transient transfection assays , Bik promotes cell death in a manner similar to the death-promoting members of the proteinBcl-2 family , Bax and Bak . |
| 1.5471 | 10.8954 | 1.0000 | In transient transfection assays , proteinBik promotes cell death in a manner similar to the death-promoting members of the Bcl-2 family , Bax and Bak . |
| 0.9260 | 1.0000 | 1.0000 | In transient transfection assays , Bik promotes cell death in a manner similar to the death-promoting members of the Bcl-2 family , proteinBax and Bak . |
| 0.9159 | 1.0000 | 1.0000 | In transient transfection assays , Bik promotes cell death in a manner similar to the death-promoting members of the Bcl-2 family , Bax and proteinBak . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5234 | 10.4222 | 1.0000 | This death-promoting activity of proteinBik can be suppressed by coexpression of Bcl-2 , Bcl-XL , EBV-BHRF1 and E1B-19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti-apoptotic proteins . |
| 0.9669 | 1.0000 | 1.0000 | This death-promoting activity of Bik can be suppressed by coexpression of Bcl-2 , proteinBcl-XL , EBV-BHRF1 and E1B-19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti-apoptotic proteins . |
| 0.9143 | 0.9999 | 1.0000 | This death-promoting activity of Bik can be suppressed by coexpression of Bcl-2 , Bcl-XL , proteinEBV-BHRF1 and E1B-19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti-apoptotic proteins . |
| 0.8919 | 1.0000 | 1.0000 | This death-promoting activity of Bik can be suppressed by coexpression of proteinBcl-2 , Bcl-XL , EBV-BHRF1 and E1B-19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti-apoptotic proteins . |
| 0.8401 | 1.0000 | 1.0000 | This death-promoting activity of Bik can be suppressed by coexpression of Bcl-2 , Bcl-XL , EBV-BHRF1 and E1B-19 kDa proteins suggesting that proteinBik may be a common target for both cellular and viral anti-apoptotic proteins . |
| 3.1624 | 10.8382 | 10.7481 | This death-promoting activity of Bik can be suppressed by coexpression of Bcl-2 , Bcl-XL , EBV-BHRF1 and proteinE1B-19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti-apoptotic proteins . |
| This death-promoting activity of Bik can be suppressed by coexpression of Bcl-2 , Bcl-XL , EBV-BHRF1 and proteinE1B-19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti-apoptotic proteins . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1624 | 20.1801 | 1.0000 | While Bik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the proteinBcl-2 family , it does share a 9 amino acid domain ( BH3 ) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins. |
| 0.9606 | 1.0000 | 1.0000 | While Bik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the Bcl-2 family , it does share a 9 amino acid domain ( proteinBH3 ) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins. |
| 0.9161 | 1.0000 | 1.0000 | While proteinBik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the Bcl-2 family , it does share a 9 amino acid domain ( BH3 ) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins. |
| 0.9025 | 1.0000 | 1.0000 | While Bik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the Bcl-2 family , it does share a 9 amino acid domain ( BH3 ) with Bax and proteinBak which may be a critical determinant for the death-promoting activity of these proteins. |
| 0.8795 | 1.0000 | 1.0000 | While Bik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the Bcl-2 family , it does share a 9 amino acid domain ( BH3 ) with proteinBax and Bak which may be a critical determinant for the death-promoting activity of these proteins. |
| 0.7276 | 1.0000 | 1.0000 | While Bik does not show overt homology to the proteinBH1 and BH2 conserved domains characteristic of the Bcl-2 family , it does share a 9 amino acid domain ( BH3 ) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins. |
| 0.6597 | 1.0000 | 1.0000 | While Bik does not show overt homology to the BH1 and proteinBH2 conserved domains characteristic of the Bcl-2 family , it does share a 9 amino acid domain ( BH3 ) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins. |
| 4.7532 | 20.9476 | 10.7372 | While Bik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the Bcl-2 family , it does share a protein9 amino acid domain ( BH3 ) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins. |
| 2.0487 | 20.6624 | 0.9912 | While Bik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the proteinBcl-2 family , it does share a 9 amino acid domain ( BH3 ) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins. |
| While Bik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the Bcl-2 family , it does share a 9 proteinamino acid domain ( BH3 ) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9589 | 30.0977 | 10.2108 | The human TCF-1 gene encodes a proteinnuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes . |
| 0.6835 | 0.8590 | 0.9972 | The DNAhuman TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1895 | 20.8410 | 0.9999 | The TCF-1 gene encodes a putative transcription factor with affinity for a sequence motif occurring in a number of DNAT-cell enhancers . |
| 2.0365 | 20.3352 | 0.9999 | The TCF-1 gene encodes a putative transcription factor with affinity for a DNAsequence motif occurring in a number of T-cell enhancers . |
| 1.5868 | 10.7079 | 0.9999 | The DNATCF-1 gene encodes a putative transcription factor with affinity for a sequence motif occurring in a number of T-cell enhancers . |
| 2.1912 | 20.1660 | 1.0000 | The TCF-1 gene encodes a putative proteintranscription factor with affinity for a sequence motif occurring in a number of T-cell enhancers . |
| The proteinTCF-1 gene encodes a putative transcription factor with affinity for a sequence motif occurring in a number of T-cell enhancers . | |||
| The TCF-1 gene encodes a proteinputative transcription factor with affinity for a sequence motif occurring in a number of T-cell enhancers . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9477 | 0.9985 | 1.0000 | RNATCF-1 mRNA was originally found to be expressed in a T cell-specific fashion within a set of human and mouse cell lines . |
| 0.9306 | 1.0000 | 0.9906 | proteinTCF-1 mRNA was originally found to be expressed in a T cell-specific fashion within a set of human and mouse cell lines . |
| TCF-1 mRNA was originally found to be expressed in a T cell-specific fashion within a set of cell_linehuman and mouse cell lines . | |||
| TCF-1 mRNA was originally found to be expressed in a T cell-specific fashion within a set of cell_linehuman and mouse cell lines . | |||
| TCF-1 mRNA was originally found to be expressed in a T cell-specific fashion within a set of human and cell_linemouse cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1292 | 20.8068 | 10.0944 | We have now raised a monoclonal antibody to document expression and biochemistry of the proteinhuman TCF-1 protein . |
| 2.1913 | 20.1097 | 1.0000 | We have now raised a proteinmonoclonal antibody to document expression and biochemistry of the human TCF-1 protein . |
| We have now raised a monoclonal antibody to document expression and biochemistry of the human proteinTCF-1 protein . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0695 | 20.7386 | 1.0000 | As expected, the proteinTCF-1 protein was detectable only in cell lines of T lineage . |
| 2.0341 | 20.3485 | 0.9984 | As expected, the TCF-1 protein was detectable only in cell_linecell lines of T lineage . |
| 1.7098 | 20.9085 | 0.9857 | As expected, the proteinTCF-1 protein was detectable only in cell lines of T lineage . |
| 0.8428 | 0.9938 | 0.9997 | As expected, the TCF-1 protein was detectable only in cell lines of cell_typeT lineage . |
| As expected, the TCF-1 protein was detectable only in cell_linecell lines of T lineage . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0193 | 20.8517 | 1.0000 | Immunohistochemistry on a panel of human tissues revealed that the proteinTCF-1 protein was found exclusively in thymocytes and in CD3+ T cells in peripheral lymphoid tissues . |
| 1.8771 | 20.7678 | 0.9939 | Immunohistochemistry on a panel of human tissues revealed that the proteinTCF-1 protein was found exclusively in thymocytes and in CD3+ T cells in peripheral lymphoid tissues . |
| 4.6566 | 20.9800 | 10.7738 | Immunohistochemistry on a panel of human tissues revealed that the TCF-1 protein was found exclusively in thymocytes and in cell_typeCD3+ T cells in peripheral lymphoid tissues . |
| 1.6178 | 10.4796 | 1.0000 | Immunohistochemistry on a panel of human tissues revealed that the TCF-1 protein was found exclusively in cell_typethymocytes and in CD3+ T cells in peripheral lymphoid tissues . |
| Immunohistochemistry on a panel of human tissues revealed that the TCF-1 protein was found exclusively in thymocytes and in CD3+ cell_typeT cells in peripheral lymphoid tissues . | |||
| Immunohistochemistry on a panel of human tissues revealed that the TCF-1 protein was found exclusively in thymocytes and in cell_lineCD3+ T cells in peripheral lymphoid tissues . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5214 | 10.7765 | 0.9999 | Western blotting yielded a set of bands ranging from protein25 kD to 55 kD, resulting from extensive alternative splicing . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3283 | 20.6284 | 0.9999 | The TCF-1 protein was detectable in all samples of a set of 22 T-cell malignancies of various stages of maturation, but was absent from a large number of other cell_typehematologic neoplasms . |
| 1.6548 | 10.9829 | 0.9928 | The proteinTCF-1 protein was detectable in all samples of a set of 22 T-cell malignancies of various stages of maturation, but was absent from a large number of other hematologic neoplasms . |
| 1.6880 | 10.5345 | 1.0000 | The proteinTCF-1 protein was detectable in all samples of a set of 22 T-cell malignancies of various stages of maturation, but was absent from a large number of other hematologic neoplasms . |
| The TCF-1 protein was detectable in all samples of a set of 22 cell_typeT-cell malignancies of various stages of maturation, but was absent from a large number of other hematologic neoplasms . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6630 | 10.9237 | 1.0000 | These observations imply a T cell-specific function for proteinTCF-1 , a notion corroborated by recent observations on Tcf-1 knock-out mice . |
| 1.6492 | 10.2290 | 1.0000 | These observations imply a T cell-specific function for TCF-1 , a notion corroborated by recent observations on proteinTcf-1 knock-out mice . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6987 | 10.9045 | 1.0000 | In addition, these results indicate that nuclear proteinTCF-1 expression can serve as a pan-T-lineage marker in the diagnosis of lymphoid malignancies . |
| 1.9106 | 20.0375 | 1.0000 | In addition, these results indicate that nuclear TCF-1 expression can serve as a proteinpan-T-lineage marker in the diagnosis of lymphoid malignancies . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8490 | 20.5259 | 10.7077 | Cross-linking of Fc gamma receptors activates DNAHIV-1 long terminal repeat -driven transcription in human monocytes . |
| 3.8272 | 20.2125 | 10.9123 | Cross-linking of proteinFc gamma receptors activates HIV-1 long terminal repeat -driven transcription in human monocytes . |
| 1.8419 | 20.3505 | 0.9992 | Cross-linking of Fc gamma receptors activates HIV-1 long terminal repeat -driven transcription in cell_typehuman monocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9362 | 20.6216 | 10.3727 | Elevation of the levels of proteincirculating immune complexes frequently accompanies HIV-1 infection and is a prognostic indicator of clinical progression from asymptomatic infection to AIDS . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9565 | 20.8556 | 10.6523 | Here we report that cross-linking of proteinFc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR . |
| 2.7650 | 10.8027 | 10.7201 | Here we report that cross-linking of Fc gamma RI or Fc gamma RII by proteinadherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR . |
| 2.2795 | 20.6136 | 0.9998 | Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific proteinanti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR . |
| 2.1443 | 20.4415 | 0.9999 | Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line BF24 and increased RNAHIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR . |
| 2.1328 | 10.9904 | 10.3229 | Here we report that cross-linking of Fc gamma RI or proteinFc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR . |
| 0.8660 | 1.0000 | 1.0000 | Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line BF24 and increased HIV RNA expression in cell_typemonocytes from HIV infected patients as assayed by reverse transcription-PCR . |
| 6.2879 | 30.5945 | 10.9094 | Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the cell_linehuman monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR . |
| 1.4826 | 20.4193 | 0.4318 | Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific proteinanti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR . |
| 0.6652 | 0.9924 | 0.9998 | Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates DNAHIV-1 gene expression in the human monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR . |
| Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the human monocytic cell line cell_lineBF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR . | |||
| Here we report that cross-linking of Fc gamma RI or Fc gamma RII by adherent human IgG or by specific anti-Fc gamma R mAb activates HIV-1 gene expression in the cell_linehuman monocytic cell line BF24 and increased HIV RNA expression in monocytes from HIV infected patients as assayed by reverse transcription-PCR . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8923 | 20.4587 | 10.3038 | In THP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the DNAlong terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . |
| 2.3326 | 30.3233 | 0.9999 | In THP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not proteinanti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . |
| 2.2171 | 10.9701 | 10.0822 | In cell_lineTHP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . |
| 2.1786 | 20.5744 | 1.0000 | In THP-1 cells , Fc gamma R cross-linking induced proteinNF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . |
| 2.1588 | 20.7887 | 0.9999 | In THP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of proteinNF-kappa B by Fc gamma R cross-linking . |
| 2.0504 | 20.7888 | 0.9999 | In THP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the DNAregulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . |
| 1.4622 | 10.0426 | 0.9992 | In THP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by proteinFc gamma R cross-linking . |
| 0.9503 | 1.0000 | 1.0000 | In THP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( DNALTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . |
| 0.9056 | 1.0000 | 1.0000 | In THP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - DNALTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . |
| 0.7308 | 0.9835 | 0.9985 | In THP-1 cells , proteinFc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . |
| 0.7224 | 0.9906 | 0.9998 | In THP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . proteinAnti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . |
| 1.9845 | 30.2548 | 10.7813 | In THP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of DNAHIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . |
| In cell_lineTHP-1 cells , Fc gamma R cross-linking induced NF-kappa B , which is known to bind to the regulatory region of the long terminal repeat ( LTR ) of HIV-1 and to activate HIV-1 transcription . Anti-TNF-alpha antibody but not anti-IL-1 beta antibody strongly inhibited both the induction of HIV-1 - LTR -driven transcription and the induction of NF-kappa B by Fc gamma R cross-linking . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5696 | 20.5186 | 10.9248 | These results indicate that proteinFc gamma R can mediate a TNF-alpha -dependent induction of HIV-1 gene transcription and suggest that immune complexes may contribute to the pathophysiology of HIV-1 infection by augmenting viral replication in monocytes . |
| 1.6000 | 10.0142 | 1.0000 | These results indicate that Fc gamma R can mediate a TNF-alpha -dependent induction of HIV-1 gene transcription and suggest that immune complexes may contribute to the pathophysiology of HIV-1 infection by augmenting viral replication in cell_typemonocytes . |
| 1.4482 | 10.3118 | 0.9999 | These results indicate that Fc gamma R can mediate a TNF-alpha -dependent induction of HIV-1 gene transcription and suggest that proteinimmune complexes may contribute to the pathophysiology of HIV-1 infection by augmenting viral replication in monocytes . |
| 1.3101 | 10.0126 | 0.9999 | These results indicate that Fc gamma R can mediate a TNF-alpha -dependent induction of DNAHIV-1 gene transcription and suggest that immune complexes may contribute to the pathophysiology of HIV-1 infection by augmenting viral replication in monocytes . |
| 0.9082 | 1.0000 | 1.0000 | These results indicate that Fc gamma R can mediate a proteinTNF-alpha -dependent induction of HIV-1 gene transcription and suggest that immune complexes may contribute to the pathophysiology of HIV-1 infection by augmenting viral replication in monocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.1301 | 10.5199 | 1.0000 | Signalling via proteinCD28 of human naive neonatal T lymphocytes . |
| 4.4342 | 20.7725 | 20.5284 | Signalling via CD28 of cell_typehuman naive neonatal T lymphocytes . |
| Signalling via CD28 of cell_linehuman naive neonatal T lymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9256 | 0.9999 | 1.0000 | proteinAccessory molecules play a crucial role in the development of the T cell response to antigenic challenge. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6245 | 10.5607 | 1.0000 | We have examined the role of proteinCD28 in modulating the ' naive' neonatal T cell response to anti-CD2 -mediated activation . |
| 0.9191 | 1.0000 | 1.0000 | We have examined the role of CD28 in modulating the ' naive' neonatal T cell response to proteinanti-CD2 -mediated activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1595 | 20.8834 | 10.0277 | To compare the role of CD28 , neonatal and adult T cells were stimulated with a pair of mitogenic anti-CD2 antibodies in the presence or absence of proteinanti- CD28 MoAb . |
| 3.1282 | 20.2298 | 10.4164 | To compare the role of CD28 , neonatal and adult T cells were stimulated with a pair of proteinmitogenic anti-CD2 antibodies in the presence or absence of anti- CD28 MoAb . |
| 1.5740 | 10.4882 | 1.0000 | To compare the role of proteinCD28 , neonatal and adult T cells were stimulated with a pair of mitogenic anti-CD2 antibodies in the presence or absence of anti- CD28 MoAb . |
| 0.9204 | 1.0000 | 0.9872 | To compare the role of CD28 , neonatal and adult T cells were stimulated with a pair of mitogenic anti-CD2 antibodies in the presence or absence of anti- proteinCD28 MoAb . |
| To compare the role of CD28 , neonatal and cell_typeadult T cells were stimulated with a pair of mitogenic anti-CD2 antibodies in the presence or absence of anti- CD28 MoAb . | |||
| To compare the role of CD28 , cell_typeneonatal and adult T cells were stimulated with a pair of mitogenic anti-CD2 antibodies in the presence or absence of anti- CD28 MoAb . | |||
| To compare the role of CD28 , neonatal and adult cell_typeT cells were stimulated with a pair of mitogenic anti-CD2 antibodies in the presence or absence of anti- CD28 MoAb . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6205 | 20.8471 | 10.8259 | With anti-CD2 alone, cell_typeneonatal T cells proliferated slightly but produced no detectable IL-2 , whereas adult T cells proliferated vigorously, with significant IL-2 production . |
| 1.6202 | 10.2405 | 1.0000 | With proteinanti-CD2 alone, neonatal T cells proliferated slightly but produced no detectable IL-2 , whereas adult T cells proliferated vigorously, with significant IL-2 production . |
| 1.5740 | 10.1523 | 1.0000 | With anti-CD2 alone, neonatal T cells proliferated slightly but produced no detectable IL-2 , whereas adult T cells proliferated vigorously, with significant proteinIL-2 production . |
| 1.4452 | 10.9707 | 1.0000 | With anti-CD2 alone, neonatal T cells proliferated slightly but produced no detectable proteinIL-2 , whereas adult T cells proliferated vigorously, with significant IL-2 production . |
| 4.2245 | 20.6159 | 10.8107 | With anti-CD2 alone, neonatal T cells proliferated slightly but produced no detectable IL-2 , whereas cell_typeadult T cells proliferated vigorously, with significant IL-2 production . |
| With anti-CD2 alone, neonatal T cells proliferated slightly but produced no detectable IL-2 , whereas adult cell_typeT cells proliferated vigorously, with significant IL-2 production . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9950 | 20.9266 | 10.9039 | Costimulation with anti- CD28 MoAb greatly enhanced the proliferative response of neonatal T cells to levels equivalent to those of adult T cells , whereas cell_typeadult T cells showed only slight increases. |
| 3.9360 | 20.9251 | 10.8672 | Costimulation with anti- CD28 MoAb greatly enhanced the proliferative response of neonatal T cells to levels equivalent to those of cell_typeadult T cells , whereas adult T cells showed only slight increases. |
| 3.3090 | 20.5459 | 10.9629 | Costimulation with anti- CD28 MoAb greatly enhanced the proliferative response of cell_typeneonatal T cells to levels equivalent to those of adult T cells , whereas adult T cells showed only slight increases. |
| 2.2710 | 20.9004 | 10.2605 | Costimulation with proteinanti- CD28 MoAb greatly enhanced the proliferative response of neonatal T cells to levels equivalent to those of adult T cells , whereas adult T cells showed only slight increases. |
| 1.8151 | 20.5072 | 0.9856 | Costimulation with anti- proteinCD28 MoAb greatly enhanced the proliferative response of neonatal T cells to levels equivalent to those of adult T cells , whereas adult T cells showed only slight increases. |
| Costimulation with anti- CD28 MoAb greatly enhanced the proliferative response of neonatal cell_typeT cells to levels equivalent to those of adult T cells , whereas adult T cells showed only slight increases. | |||
| Costimulation with anti- CD28 MoAb greatly enhanced the proliferative response of neonatal T cells to levels equivalent to those of adult T cells , whereas adult cell_typeT cells showed only slight increases. | |||
| Costimulation with anti- CD28 MoAb greatly enhanced the proliferative response of neonatal T cells to levels equivalent to those of adult cell_typeT cells , whereas adult T cells showed only slight increases. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9916 | 20.7616 | 10.4792 | Although IL-2 secretion was increased in the presence of proteinanti- CD28 MoAb , neonatal T cell IL-2 production remained lower than in adults . |
| 2.7824 | 10.3885 | 10.4959 | Although IL-2 secretion was increased in the presence of anti- CD28 MoAb , cell_typeneonatal T cell IL-2 production remained lower than in adults . |
| 0.9583 | 1.0000 | 0.9999 | Although IL-2 secretion was increased in the presence of anti- CD28 MoAb , neonatal T cell proteinIL-2 production remained lower than in adults . |
| 0.9396 | 1.0000 | 1.0000 | Although proteinIL-2 secretion was increased in the presence of anti- CD28 MoAb , neonatal T cell IL-2 production remained lower than in adults . |
| 0.9000 | 1.0000 | 0.9731 | Although IL-2 secretion was increased in the presence of anti- proteinCD28 MoAb , neonatal T cell IL-2 production remained lower than in adults . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0685 | 20.0866 | 0.9940 | In contrast, enhancement of proteinIL-2 mRNA expression in neonates was similar to adult levels . |
| 1.6841 | 10.8504 | 1.0000 | In contrast, enhancement of RNAIL-2 mRNA expression in neonates was similar to adult levels . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5761 | 20.2877 | 10.8888 | Anti- CD28 MoAb costimulation increased proteinNF kappa B levels in neonates , albeit to levels lower than that of adults . |
| 0.9503 | 1.0000 | 0.9755 | Anti- proteinCD28 MoAb costimulation increased NF kappa B levels in neonates , albeit to levels lower than that of adults . |
| 0.8283 | 0.9905 | 0.9997 | proteinAnti- CD28 MoAb costimulation increased NF kappa B levels in neonates , albeit to levels lower than that of adults . |
| 0.4646 | 0.9994 | 0.5364 | proteinAnti- CD28 MoAb costimulation increased NF kappa B levels in neonates , albeit to levels lower than that of adults . |
| Anti- proteinCD28 MoAb costimulation increased NF kappa B levels in neonates , albeit to levels lower than that of adults . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6198 | 20.3086 | 10.6316 | The cellular mechanism governing the diminished proliferative response of neonatal T lymphocytes to anti-CD2 may therefore be due to decreased proteinNF kappa B induction , reduced IL-2 mRNA expression and deficient IL-2 production . |
| 3.5498 | 20.6067 | 10.6004 | The cellular mechanism governing the diminished proliferative response of cell_typeneonatal T lymphocytes to anti-CD2 may therefore be due to decreased NF kappa B induction , reduced IL-2 mRNA expression and deficient IL-2 production . |
| 2.0238 | 20.0052 | 0.9912 | The cellular mechanism governing the diminished proliferative response of neonatal T lymphocytes to anti-CD2 may therefore be due to decreased NF kappa B induction , reduced proteinIL-2 mRNA expression and deficient IL-2 production . |
| 1.4243 | 10.7612 | 1.0000 | The cellular mechanism governing the diminished proliferative response of neonatal T lymphocytes to anti-CD2 may therefore be due to decreased NF kappa B induction , reduced RNAIL-2 mRNA expression and deficient IL-2 production . |
| 0.8559 | 1.0000 | 1.0000 | The cellular mechanism governing the diminished proliferative response of neonatal T lymphocytes to proteinanti-CD2 may therefore be due to decreased NF kappa B induction , reduced IL-2 mRNA expression and deficient IL-2 production . |
| 0.8354 | 1.0000 | 1.0000 | The cellular mechanism governing the diminished proliferative response of neonatal T lymphocytes to anti-CD2 may therefore be due to decreased NF kappa B induction , reduced IL-2 mRNA expression and deficient proteinIL-2 production . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1855 | 10.6888 | 10.5775 | Although proteinanti- CD28 MoAb costimulation enhances all of the above signals, NF kappa B and IL-2 levels remain lower than in adults , suggesting the need for further activation requirements in the neonate . |
| 0.9601 | 1.0000 | 0.9854 | Although anti- proteinCD28 MoAb costimulation enhances all of the above signals, NF kappa B and IL-2 levels remain lower than in adults , suggesting the need for further activation requirements in the neonate . |
| 3.7894 | 20.7987 | 10.8065 | Although anti- CD28 MoAb costimulation enhances all of the above signals, proteinNF kappa B and IL-2 levels remain lower than in adults , suggesting the need for further activation requirements in the neonate . |
| 0.9077 | 1.0000 | 1.0000 | Although anti- CD28 MoAb costimulation enhances all of the above signals, NF kappa B and proteinIL-2 levels remain lower than in adults , suggesting the need for further activation requirements in the neonate . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4037 | 20.1058 | 10.5493 | TCL1 oncogene activation in cell_typepreleukemic T cells from a case of ataxia-telangiectasia . |
| 0.8428 | 0.9987 | 0.9999 | DNATCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia . |
| TCL1 oncogene activation in preleukemic cell_typeT cells from a case of ataxia-telangiectasia . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6281 | 20.0300 | 10.6804 | The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [ t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1) ] and inversions [ inv14(q11;q32.1) ] with DNATCR alpha/beta loci in T-cell leukemias , such as T-prolymphocytic ( T-PLL ). |
| 1.4931 | 10.4637 | 0.9999 | The DNATCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [ t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1) ] and inversions [ inv14(q11;q32.1) ] with TCR alpha/beta loci in T-cell leukemias , such as T-prolymphocytic ( T-PLL ). |
| 0.8545 | 1.0000 | 1.0000 | The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [ t(14;14)(q11;q32.1) and DNAt(7;14)(q35;q32.1) ] and inversions [ inv14(q11;q32.1) ] with TCR alpha/beta loci in T-cell leukemias , such as T-prolymphocytic ( T-PLL ). |
| 0.8499 | 1.0000 | 1.0000 | The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [ t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1) ] and inversions [ DNAinv14(q11;q32.1) ] with TCR alpha/beta loci in T-cell leukemias , such as T-prolymphocytic ( T-PLL ). |
| 0.8295 | 0.9999 | 1.0000 | The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [ DNAt(14;14)(q11;q32.1) and t(7;14)(q35;q32.1) ] and inversions [ inv14(q11;q32.1) ] with TCR alpha/beta loci in T-cell leukemias , such as T-prolymphocytic ( T-PLL ). |
| 2.3543 | 10.7073 | 10.9608 | The TCL1 oncogene on DNAhuman chromosome 14q32.1 is involved in chromosome translocations [ t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1) ] and inversions [ inv14(q11;q32.1) ] with TCR alpha/beta loci in T-cell leukemias , such as T-prolymphocytic ( T-PLL ). |
| 0.8153 | 1.0000 | 1.0000 | The TCL1 oncogene on human chromosome 14q32.1 is involved in chromosome translocations [ t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1) ] and DNAinversions [ inv14(q11;q32.1) ] with TCR alpha/beta loci in T-cell leukemias , such as T-prolymphocytic ( T-PLL ). |
| 0.5904 | 0.9946 | 1.0000 | The TCL1 oncogene on human chromosome 14q32.1 is involved in DNAchromosome translocations [ t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1) ] and inversions [ inv14(q11;q32.1) ] with TCR alpha/beta loci in T-cell leukemias , such as T-prolymphocytic ( T-PLL ). |
| The TCL1 oncogene on DNAhuman chromosome 14q32.1 is involved in chromosome translocations [ t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1) ] and inversions [ inv14(q11;q32.1) ] with TCR alpha/beta loci in T-cell leukemias , such as T-prolymphocytic ( T-PLL ). | |||
| The TCL1 oncogene on human chromosome DNA14q32.1 is involved in chromosome translocations [ t(14;14)(q11;q32.1) and t(7;14)(q35;q32.1) ] and inversions [ inv14(q11;q32.1) ] with TCR alpha/beta loci in T-cell leukemias , such as T-prolymphocytic ( T-PLL ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7136 | 10.3913 | 0.9999 | Similar chromosomal rearrangements occur also in the clonally expanded cell_typeT cells in AT patients before the appearance of the overt leukemia . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0217 | 10.9434 | 10.8882 | We have analyzed the expression of TCL1 mRNA and protein in cell_typeperipheral blood lymphocytes ( PBLs ) from four AT cases and from healthy controls . |
| 2.4974 | 20.1523 | 1.0000 | We have analyzed the expression of RNATCL1 mRNA and protein in peripheral blood lymphocytes ( PBLs ) from four AT cases and from healthy controls . |
| 0.9484 | 1.0000 | 1.0000 | We have analyzed the expression of TCL1 mRNA and protein in peripheral blood lymphocytes ( cell_typePBLs ) from four AT cases and from healthy controls . |
| 2.0811 | 20.2596 | 0.9928 | We have analyzed the expression of proteinTCL1 mRNA and protein in peripheral blood lymphocytes ( PBLs ) from four AT cases and from healthy controls . |
| We have analyzed the expression of TCL1 mRNA and proteinprotein in peripheral blood lymphocytes ( PBLs ) from four AT cases and from healthy controls . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1060 | 20.8849 | 1.0000 | We found that the DNATCL1 gene was overexpressed in the PBLs of an AT patient with a large clonal T-cell population exhibiting the t(14;14) translocation but not in the lymphocytes of the other cases. |
| 1.6869 | 10.1412 | 1.0000 | We found that the TCL1 gene was overexpressed in the PBLs of an AT patient with a large clonal T-cell population exhibiting the t(14;14) translocation but not in the cell_typelymphocytes of the other cases. |
| 1.6792 | 10.4845 | 1.0000 | We found that the TCL1 gene was overexpressed in the cell_typePBLs of an AT patient with a large clonal T-cell population exhibiting the t(14;14) translocation but not in the lymphocytes of the other cases. |
| 2.8879 | 20.5782 | 10.6149 | We found that the TCL1 gene was overexpressed in the PBLs of an AT patient with a large cell_typeclonal T-cell population exhibiting the t(14;14) translocation but not in the lymphocytes of the other cases. |
| 2.1176 | 20.3869 | 0.9999 | We found that the TCL1 gene was overexpressed in the PBLs of an AT patient with a large clonal T-cell population exhibiting the DNAt(14;14) translocation but not in the lymphocytes of the other cases. |
| 1.9679 | 20.9319 | 0.9910 | We found that the proteinTCL1 gene was overexpressed in the PBLs of an AT patient with a large clonal T-cell population exhibiting the t(14;14) translocation but not in the lymphocytes of the other cases. |
| We found that the TCL1 gene was overexpressed in the PBLs of an AT patient with a cell_linelarge clonal T-cell population exhibiting the t(14;14) translocation but not in the lymphocytes of the other cases. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5990 | 30.3097 | 10.5166 | Fluorescence in situ hybridization of the DNATCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the t(14;14) translocation lies within the TCL1 locus and is accompanied by an inverted duplication of the distal part of chromosome 14 . |
| 2.2292 | 20.4667 | 1.0000 | Fluorescence in situ hybridization of the TCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the t(14;14) translocation lies within the DNATCL1 locus and is accompanied by an inverted duplication of the distal part of chromosome 14 . |
| 0.8712 | 0.9982 | 0.9998 | Fluorescence in situ hybridization of the TCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the t(14;14) translocation lies within the TCL1 locus and is accompanied by an inverted duplication of the distal part of DNAchromosome 14 . |
| 3.1400 | 30.2661 | 10.0006 | Fluorescence in situ hybridization of the TCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the t(14;14) translocation lies within the TCL1 locus and is accompanied by an inverted duplication of the DNAdistal part of chromosome 14 . |
| 2.2047 | 20.9610 | 0.9999 | Fluorescence in situ hybridization of the TCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the DNAt(14;14) translocation lies within the TCL1 locus and is accompanied by an inverted duplication of the distal part of chromosome 14 . |
| Fluorescence in situ hybridization of the TCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the t(14;14) translocation lies within the TCL1 locus and is accompanied by an DNAinverted duplication of the distal part of chromosome 14 . | |||
| Fluorescence in situ hybridization of the TCL1 genomic locus to lymphocyte metaphases from the AT patient with the T-cell clonal expansion showed that the breakpoint of the t(14;14) translocation lies within the TCL1 locus and is accompanied by an inverted duplication of the DNAdistal part of chromosome 14 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0529 | 20.3074 | 0.9999 | These data indicate that TCL1 is activated in preleukemic clonal cells as a consequence of chromosome translocation involving sequences from the DNATCR locus at 14q11 . |
| 0.9167 | 1.0000 | 1.0000 | These data indicate that TCL1 is activated in preleukemic clonal cells as a consequence of chromosome translocation involving sequences from the TCR locus at DNA14q11 . |
| 3.5523 | 20.3015 | 10.6508 | These data indicate that TCL1 is activated in cell_typepreleukemic clonal cells as a consequence of chromosome translocation involving sequences from the TCR locus at 14q11 . |
| 1.5239 | 10.6910 | 1.0000 | These data indicate that proteinTCL1 is activated in preleukemic clonal cells as a consequence of chromosome translocation involving sequences from the TCR locus at 14q11 . |
| These data indicate that DNATCL1 is activated in preleukemic clonal cells as a consequence of chromosome translocation involving sequences from the TCR locus at 14q11 . | |||
| These data indicate that TCL1 is activated in cell_linepreleukemic clonal cells as a consequence of chromosome translocation involving sequences from the TCR locus at 14q11 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7669 | 10.7941 | 1.0000 | Deregulation of proteinTCL1 is the first event in the initiation of malignancy in these types of leukemias and represents a potential tool for clinical evaluation . |
| Deregulation of DNATCL1 is the first event in the initiation of malignancy in these types of leukemias and represents a potential tool for clinical evaluation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.3410 | 30.7956 | 20.6807 | C/EBP proteins activate transcription from the DNAhuman immunodeficiency virus type 1 long terminal repeat in macrophages/ monocytes . |
| 0.8921 | 1.0000 | 0.9999 | C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/ cell_typemonocytes . |
| 0.8011 | 0.9998 | 0.9999 | proteinC/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/ monocytes . |
| 1.4564 | 10.5825 | 0.9995 | C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in cell_typemacrophages/ monocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2203 | 10.2391 | 20.6367 | Three binding sites for C/EBP proteins are found in the DNAhuman immunodeficiency virus type 1 ( HIV-1 ) long terminal repeat ( LTR ) (V.M. Tesmer, A.Rajadhyaksha, J.Babin, and M.Bina, Proc.Natl.Acad.Sci. USA 90:7298-7302, 1993). |
| 1.3891 | 10.6204 | 1.0000 | Three binding sites for proteinC/EBP proteins are found in the human immunodeficiency virus type 1 ( HIV-1 ) long terminal repeat ( LTR ) (V.M. Tesmer, A.Rajadhyaksha, J.Babin, and M.Bina, Proc.Natl.Acad.Sci. USA 90:7298-7302, 1993). |
| 0.9511 | 0.9999 | 1.0000 | Three binding sites for C/EBP proteins are found in the human immunodeficiency virus type 1 ( HIV-1 ) long terminal repeat ( DNALTR ) (V.M. Tesmer, A.Rajadhyaksha, J.Babin, and M.Bina, Proc.Natl.Acad.Sci. USA 90:7298-7302, 1993). |
| 1.2664 | 10.0766 | 0.9999 | Three DNAbinding sites for C/EBP proteins are found in the human immunodeficiency virus type 1 ( HIV-1 ) long terminal repeat ( LTR ) (V.M. Tesmer, A.Rajadhyaksha, J.Babin, and M.Bina, Proc.Natl.Acad.Sci. USA 90:7298-7302, 1993). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0882 | 20.7166 | 10.5902 | We have determined the functional role of C/EBP proteins and C/EBP sites in regulating transcription from the DNAHIV- 1 LTR in monocytes /macrophages . |
| 2.1685 | 20.5603 | 1.0000 | We have determined the functional role of proteinC/EBP proteins and C/EBP sites in regulating transcription from the HIV- 1 LTR in monocytes /macrophages . |
| 1.6598 | 10.7212 | 0.9998 | We have determined the functional role of C/EBP proteins and C/EBP sites in regulating transcription from the HIV- 1 LTR in cell_typemonocytes /macrophages . |
| 1.5489 | 10.8268 | 0.9999 | We have determined the functional role of C/EBP proteins and DNAC/EBP sites in regulating transcription from the HIV- 1 LTR in monocytes /macrophages . |
| 1.5330 | 10.8885 | 0.9762 | We have determined the functional role of C/EBP proteins and C/EBP sites in regulating transcription from the HIV- 1 LTR in cell_typemonocytes /macrophages . |
| 0.7909 | 1.0000 | 0.9998 | We have determined the functional role of C/EBP proteins and C/EBP sites in regulating transcription from the HIV- 1 LTR in monocytes cell_type/macrophages . |
| 0.5110 | 0.9999 | 0.9994 | We have determined the functional role of C/EBP proteins and C/EBP sites in regulating transcription from the HIV- DNA1 LTR in monocytes /macrophages . |
| We have determined the functional role of C/EBP proteins and C/EBP sites in regulating transcription from the HIV- 1 DNALTR in monocytes /macrophages . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.8230 | 20.5894 | 10.9193 | Inhibition of endogenous C/EBP proteins , using either an excess of C/EBP binding sites or a trans- dominant negative inhibitor , demonstrated that C/EBP proteins are required for basal and activated levels of HIV-1 LTR transcription in the cell_linepromonocytic cell line U937 . |
| 3.5942 | 20.5352 | 10.6011 | Inhibition of endogenous C/EBP proteins , using either an excess of DNAC/EBP binding sites or a trans- dominant negative inhibitor , demonstrated that C/EBP proteins are required for basal and activated levels of HIV-1 LTR transcription in the promonocytic cell line U937 . |
| 2.6286 | 20.6935 | 10.4441 | Inhibition of proteinendogenous C/EBP proteins , using either an excess of C/EBP binding sites or a trans- dominant negative inhibitor , demonstrated that C/EBP proteins are required for basal and activated levels of HIV-1 LTR transcription in the promonocytic cell line U937 . |
| 2.0999 | 20.7844 | 0.9999 | Inhibition of endogenous C/EBP proteins , using either an excess of C/EBP binding sites or a trans- dominant negative inhibitor , demonstrated that C/EBP proteins are required for basal and activated levels of DNAHIV-1 LTR transcription in the promonocytic cell line U937 . |
| 1.4713 | 20.0988 | 10.2876 | Inhibition of endogenous proteinC/EBP proteins , using either an excess of C/EBP binding sites or a trans- dominant negative inhibitor , demonstrated that C/EBP proteins are required for basal and activated levels of HIV-1 LTR transcription in the promonocytic cell line U937 . |
| 1.4624 | 10.8494 | 1.0000 | Inhibition of endogenous C/EBP proteins , using either an excess of C/EBP binding sites or a trans- dominant negative inhibitor , demonstrated that proteinC/EBP proteins are required for basal and activated levels of HIV-1 LTR transcription in the promonocytic cell line U937 . |
| Inhibition of endogenous C/EBP proteins , using either an excess of C/EBP binding sites or a trans- dominant negative inhibitor , demonstrated that C/EBP proteins are required for basal and activated levels of HIV-1 DNALTR transcription in the promonocytic cell line U937 . | |||
| Inhibition of endogenous C/EBP proteins , using either an excess of C/EBP binding sites or a DNAtrans- dominant negative inhibitor , demonstrated that C/EBP proteins are required for basal and activated levels of HIV-1 LTR transcription in the promonocytic cell line U937 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3272 | 20.4828 | 0.9999 | Northern (RNA) blots and binding assays showed that NF-IL6 is the only known proteinC/EBP family member which is increased when U937 cells are activated. |
| 2.3026 | 20.0753 | 0.9999 | Northern (RNA) blots and binding assays showed that NF-IL6 is the only known C/EBP family member which is increased when cell_lineU937 cells are activated. |
| 1.7439 | 10.1159 | 1.0000 | Northern (RNA) blots and binding assays showed that proteinNF-IL6 is the only known C/EBP family member which is increased when U937 cells are activated. |
| 1.7927 | 20.6283 | 0.7600 | Northern (RNA) blots and binding assays showed that NF-IL6 is the only known proteinC/EBP family member which is increased when U937 cells are activated. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2800 | 20.2648 | 1.0000 | Mutational analyses of the DNAHIV-1 LTR showed that one C/EBP site is required for normal LTR transcription both before and after cellular activation and that the two 3' C/EBP sites are functionally equivalent. |
| 1.5341 | 10.9706 | 1.0000 | Mutational analyses of the HIV-1 LTR showed that one DNAC/EBP site is required for normal LTR transcription both before and after cellular activation and that the two 3' C/EBP sites are functionally equivalent. |
| 0.8583 | 0.9999 | 1.0000 | Mutational analyses of the HIV-1 LTR showed that one C/EBP site is required for normal DNALTR transcription both before and after cellular activation and that the two 3' C/EBP sites are functionally equivalent. |
| 3.9240 | 20.8831 | 10.9958 | Mutational analyses of the HIV-1 LTR showed that one C/EBP site is required for normal LTR transcription both before and after cellular activation and that the two DNA3' C/EBP sites are functionally equivalent. |
| Mutational analyses of the HIV-1 DNALTR showed that one C/EBP site is required for normal LTR transcription both before and after cellular activation and that the two 3' C/EBP sites are functionally equivalent. | |||
| Mutational analyses of the HIV-1 LTR showed that one C/EBP site is required for normal LTR transcription both before and after cellular activation and that the two 3' DNAC/EBP sites are functionally equivalent. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2770 | 20.2658 | 0.9999 | However, transcription from crippled HIV-1 LTRs lacking C/EBP sites can still be induced following activation of cell_lineU937 cells . |
| 1.5404 | 10.6795 | 0.9998 | However, transcription from crippled HIV-1 LTRs lacking DNAC/EBP sites can still be induced following activation of U937 cells . |
| 2.3804 | 20.0077 | 0.9999 | However, transcription from crippled DNAHIV-1 LTRs lacking C/EBP sites can still be induced following activation of U937 cells . |
| However, transcription from crippled HIV-1 DNALTRs lacking C/EBP sites can still be induced following activation of U937 cells . | |||
| However, transcription from DNAcrippled HIV-1 LTRs lacking C/EBP sites can still be induced following activation of U937 cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7786 | 10.2203 | 1.0000 | Several models are suggested for how elevated NF-IL6 may participate in an autostimulatory loop involving HIV infection , macrophage activation , proteincytokine expression , and HIV replication . |
| 1.7038 | 10.7505 | 1.0000 | Several models are suggested for how elevated proteinNF-IL6 may participate in an autostimulatory loop involving HIV infection , macrophage activation , cytokine expression , and HIV replication . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7506 | 10.3044 | 1.0000 | Human immunodeficiency virus type-2 gene expression : two DNAenhancers and their activation by T-cell activators . |
| 2.1295 | 20.6464 | 0.9999 | Human immunodeficiency virus type-2 gene expression : two enhancers and their activation by proteinT-cell activators . |
| Human immunodeficiency virus type-2 gene expression : two enhancers and their activation by cell_typeT-cell activators . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8288 | 20.7255 | 10.5542 | Since expression of the viruses is in large part regulated by the sequence elements in their DNAlong terminal repeats ( LTRs ), this study was directed to an analysis of the regulatory elements in the HIV-2 LTR . |
| 2.2422 | 20.5243 | 0.9999 | Since expression of the viruses is in large part regulated by the sequence elements in their long terminal repeats ( LTRs ), this study was directed to an analysis of the regulatory elements in the DNAHIV-2 LTR . |
| 2.1973 | 20.9094 | 0.9999 | Since expression of the viruses is in large part regulated by the sequence elements in their long terminal repeats ( LTRs ), this study was directed to an analysis of the DNAregulatory elements in the HIV-2 LTR . |
| 1.3781 | 10.8863 | 0.9999 | Since expression of the viruses is in large part regulated by the DNAsequence elements in their long terminal repeats ( LTRs ), this study was directed to an analysis of the regulatory elements in the HIV-2 LTR . |
| 0.9542 | 1.0000 | 1.0000 | Since expression of the viruses is in large part regulated by the sequence elements in their long terminal repeats ( DNALTRs ), this study was directed to an analysis of the regulatory elements in the HIV-2 LTR . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7044 | 10.0182 | 1.0000 | The HIV-2 LTR was found to contain two DNAenhancers . |
| 1.5371 | 10.6581 | 1.0000 | The DNAHIV-2 LTR was found to contain two enhancers . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2409 | 20.1892 | 0.9999 | One of these enhancers is, in part, identical to the DNAHIV-1 enhancer . |
| 1.7163 | 10.5607 | 0.9999 | One of these DNAenhancers is, in part, identical to the HIV-1 enhancer . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1599 | 20.8382 | 10.8746 | This enhancer in HIV-1 is the DNAT-cell activation response element ; in HIV-2 , however, it is the second enhancer that is mainly responsible for activation in response to T-cell activators . |
| 0.8747 | 0.9999 | 1.0000 | This DNAenhancer in HIV-1 is the T-cell activation response element ; in HIV-2 , however, it is the second enhancer that is mainly responsible for activation in response to T-cell activators . |
| 2.2102 | 20.8710 | 0.9999 | This enhancer in HIV-1 is the T-cell activation response element ; in HIV-2 , however, it is the second enhancer that is mainly responsible for activation in response to proteinT-cell activators . |
| 0.9028 | 1.0000 | 1.0000 | This enhancer in HIV-1 is the T-cell activation response element ; in HIV-2 , however, it is the second DNAenhancer that is mainly responsible for activation in response to T-cell activators . |
| This enhancer in HIV-1 is the T-cell activation response element ; in HIV-2 , however, it is the DNAsecond enhancer that is mainly responsible for activation in response to T-cell activators . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7103 | 20.3215 | 10.8533 | The second enhancer interacts with two proteinnuclear binding proteins (85 kD and 27 kD mobility) that appear to be required for optimal enhancer function and activation. |
| 0.9274 | 1.0000 | 1.0000 | The second DNAenhancer interacts with two nuclear binding proteins (85 kD and 27 kD mobility) that appear to be required for optimal enhancer function and activation. |
| 0.5866 | 0.9999 | 0.9999 | The second enhancer interacts with two nuclear binding proteins (85 kD and 27 kD mobility) that appear to be required for optimal DNAenhancer function and activation. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4421 | 20.9012 | 10.8154 | NF-M ( chicken C/EBP beta ) induces eosinophilic differentiation and apoptosis in a cell_linehematopoietic progenitor cell line . |
| 2.7871 | 20.1928 | 10.4456 | NF-M ( proteinchicken C/EBP beta ) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line . |
| 0.9565 | 1.0000 | 1.0000 | proteinNF-M ( chicken C/EBP beta ) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5496 | 0.9985 | 10.3579 | proteinCAAT/enhancer binding proteins ( C/EBPs ) are transcriptional activators implicated in the differentiation processes of various cell lineages. |
| 0.9744 | 1.0000 | 1.0000 | CAAT/enhancer binding proteins ( proteinC/EBPs ) are transcriptional activators implicated in the differentiation processes of various cell lineages. |
| 1.3691 | 10.7820 | 0.9999 | CAAT/enhancer binding proteins ( C/EBPs ) are proteintranscriptional activators implicated in the differentiation processes of various cell lineages. |
| DNACAAT/enhancer binding proteins ( C/EBPs ) are transcriptional activators implicated in the differentiation processes of various cell lineages. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6187 | 10.9194 | 1.0000 | We have shown earlier that NF-M , the chicken homolog of proteinC/EBP beta , is specifically expressed in myelomonocytic and eosinophilic cells of the hematopoietic system. |
| 0.9430 | 1.0000 | 1.0000 | We have shown earlier that proteinNF-M , the chicken homolog of C/EBP beta , is specifically expressed in myelomonocytic and eosinophilic cells of the hematopoietic system. |
| We have shown earlier that NF-M , the proteinchicken homolog of C/EBP beta , is specifically expressed in myelomonocytic and eosinophilic cells of the hematopoietic system. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5658 | 20.5978 | 10.7981 | To investigate the role of NF-M in hematopoietic cell lineage commitment, we constructed a conditional form of the protein by fusing it to the proteinhormone binding domain of the human estrogen receptor . |
| 3.5070 | 20.5118 | 10.9116 | To investigate the role of NF-M in hematopoietic cell lineage commitment, we constructed a conditional form of the protein by fusing it to the hormone binding domain of the proteinhuman estrogen receptor . |
| 1.4849 | 10.3554 | 1.0000 | To investigate the role of proteinNF-M in hematopoietic cell lineage commitment, we constructed a conditional form of the protein by fusing it to the hormone binding domain of the human estrogen receptor . |
| 2.8804 | 10.9400 | 10.6595 | To investigate the role of NF-M in cell_typehematopoietic cell lineage commitment, we constructed a conditional form of the protein by fusing it to the hormone binding domain of the human estrogen receptor . |
| To investigate the role of NF-M in cell_linehematopoietic cell lineage commitment, we constructed a conditional form of the protein by fusing it to the hormone binding domain of the human estrogen receptor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9603 | 20.3572 | 10.7019 | This construct was stably expressed in a cell_linemultipotent progenitor cell line transformed by the Myb-Ets oncoprotein . |
| 1.9461 | 20.0867 | 0.9999 | This construct was stably expressed in a multipotent progenitor cell line transformed by the proteinMyb-Ets oncoprotein . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8449 | 30.6074 | 10.4929 | We report here that both NF-M -dependent promoter constructs and resident genes could be activated by addition of beta-estradiol to the cell_lineNF-M -estrogen receptor expressing progenitors . |
| 3.7583 | 20.9861 | 10.4425 | We report here that both DNANF-M -dependent promoter constructs and resident genes could be activated by addition of beta-estradiol to the NF-M -estrogen receptor expressing progenitors . |
| 1.9064 | 20.5014 | 0.9964 | We report here that both proteinNF-M -dependent promoter constructs and resident genes could be activated by addition of beta-estradiol to the NF-M -estrogen receptor expressing progenitors . |
| 1.2744 | 20.4724 | 0.9982 | We report here that both NF-M -dependent promoter constructs and resident genes could be activated by addition of beta-estradiol to the proteinNF-M -estrogen receptor expressing progenitors . |
| 1.3322 | 10.5531 | 0.9997 | We report here that both NF-M -dependent promoter constructs and DNAresident genes could be activated by addition of beta-estradiol to the NF-M -estrogen receptor expressing progenitors . |
| We report here that both NF-M -dependent promoter constructs and resident genes could be activated by addition of beta-estradiol to the proteinNF-M -estrogen receptor expressing progenitors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9446 | 20.6766 | 10.4322 | At the same time, we observed a down-regulation of proteinprogenitor-specific surface markers and the up-regulation of differentiation markers restricted to the eosinophil and myeloid lineages . |
| 1.5272 | 10.9978 | 1.0000 | At the same time, we observed a down-regulation of progenitor-specific surface markers and the up-regulation of proteindifferentiation markers restricted to the eosinophil and myeloid lineages . |
| At the same time, we observed a down-regulation of progenitor-specific surface markers and the up-regulation of differentiation markers restricted to the cell_typeeosinophil and myeloid lineages . | |||
| At the same time, we observed a down-regulation of progenitor-specific surface markers and the up-regulation of differentiation markers restricted to the eosinophil and cell_typemyeloid lineages . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3727 | 20.1851 | 1.0000 | Our results suggest that NF-M plays an important role in commitment along the cell_typeeosinophil lineage and in the induction of apoptosis . |
| 1.6201 | 10.7237 | 1.0000 | Our results suggest that proteinNF-M plays an important role in commitment along the eosinophil lineage and in the induction of apoptosis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8454 | 20.6445 | 10.6975 | Prolactin and interleukin-2 receptors in T lymphocytes signal through a proteinMGF-STAT5-like transcription factor . |
| 1.3122 | 10.9192 | 0.9998 | Prolactin and interleukin-2 receptors in cell_typeT lymphocytes signal through a MGF-STAT5-like transcription factor . |
| 1.2401 | 10.5236 | 0.9999 | Prolactin and proteininterleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor . |
| proteinProlactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor . | |||
| Prolactin and proteininterleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1068 | 20.3510 | 0.9999 | The cell surface receptors for PRL and interleukin-2 ( IL-2 ) are structurally distinct, but share regulatory tasks in cell_typeT lymphocytes . |
| 0.9802 | 1.0000 | 1.0000 | The cell surface receptors for PRL and interleukin-2 ( proteinIL-2 ) are structurally distinct, but share regulatory tasks in T lymphocytes . |
| 0.9310 | 1.0000 | 1.0000 | The cell surface receptors for proteinPRL and interleukin-2 ( IL-2 ) are structurally distinct, but share regulatory tasks in T lymphocytes . |
| 0.9126 | 1.0000 | 1.0000 | The cell surface receptors for PRL and proteininterleukin-2 ( IL-2 ) are structurally distinct, but share regulatory tasks in T lymphocytes . |
| 3.0055 | 10.8709 | 10.6211 | The proteincell surface receptors for PRL and interleukin-2 ( IL-2 ) are structurally distinct, but share regulatory tasks in T lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6263 | 10.6210 | 0.9998 | They can stimulate proliferation and activate transcription of over-lapping sets of genes of cell_typeT cells . |
| 0.6415 | 0.9996 | 1.0000 | They can stimulate proliferation and activate transcription of over-lapping sets of DNAgenes of T cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.2153 | 30.6014 | 20.9707 | PRL and IL-2 receptor activation are both linked to the Jak/Stat ( proteinsignal transducer and activator of transcription ) pathway . |
| 1.5752 | 10.4348 | 1.0000 | PRL and IL-2 receptor activation are both linked to the proteinJak/Stat ( signal transducer and activator of transcription ) pathway . |
| 0.8486 | 1.0000 | 1.0000 | proteinPRL and IL-2 receptor activation are both linked to the Jak/Stat ( signal transducer and activator of transcription ) pathway . |
| 0.7868 | 0.9999 | 1.0000 | PRL and proteinIL-2 receptor activation are both linked to the Jak/Stat ( signal transducer and activator of transcription ) pathway . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8434 | 10.7788 | 10.5447 | We investigated the ability of PRL and IL-2 to activate Stat proteins in different cell_lineT cell lines . |
| 1.6419 | 10.0969 | 1.0000 | We investigated the ability of proteinPRL and IL-2 to activate Stat proteins in different T cell lines . |
| 1.3381 | 10.7921 | 0.9999 | We investigated the ability of PRL and IL-2 to activate proteinStat proteins in different T cell lines . |
| 0.9033 | 1.0000 | 1.0000 | We investigated the ability of PRL and proteinIL-2 to activate Stat proteins in different T cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9575 | 1.0000 | 1.0000 | The DNA binding specificities, the reactivities toward Stat-specific antisera , and the mol wt of IL-2 -and proteinPRL -induced DNA-binding proteins in Nb2 and C196 T cell lines were investigated. |
| 0.9376 | 1.0000 | 1.0000 | The DNA binding specificities, the reactivities toward Stat-specific antisera , and the mol wt of proteinIL-2 -and PRL -induced DNA-binding proteins in Nb2 and C196 T cell lines were investigated. |
| The DNA binding specificities, the reactivities toward Stat-specific antisera , and the mol wt of IL-2 -and proteinPRL -induced DNA-binding proteins in Nb2 and C196 T cell lines were investigated. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9427 | 20.6540 | 10.6383 | A comparison with the Stat proteins induced by interferon-gamma , PRL , and IL-6 in cell_lineT47D mammary tumor cells was made. |
| 1.9449 | 20.1959 | 0.9999 | A comparison with the proteinStat proteins induced by interferon-gamma , PRL , and IL-6 in T47D mammary tumor cells was made. |
| 1.5381 | 10.4716 | 1.0000 | A comparison with the Stat proteins induced by interferon-gamma , PRL , and proteinIL-6 in T47D mammary tumor cells was made. |
| 0.9351 | 1.0000 | 1.0000 | A comparison with the Stat proteins induced by interferon-gamma , proteinPRL , and IL-6 in T47D mammary tumor cells was made. |
| 0.8509 | 1.0000 | 1.0000 | A comparison with the Stat proteins induced by proteininterferon-gamma , PRL , and IL-6 in T47D mammary tumor cells was made. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5698 | 20.8722 | 10.5341 | A transcription factor closely related to proteinmammary gland factor-Stat5 is rapidly activated upon interaction of IL-2 and PRL with their respective receptors. |
| 0.8995 | 1.0000 | 1.0000 | A transcription factor closely related to mammary gland factor-Stat5 is rapidly activated upon interaction of IL-2 and proteinPRL with their respective receptors. |
| 0.8676 | 0.9999 | 1.0000 | A transcription factor closely related to mammary gland factor-Stat5 is rapidly activated upon interaction of proteinIL-2 and PRL with their respective receptors. |
| 1.3875 | 10.7829 | 0.9999 | A proteintranscription factor closely related to mammary gland factor-Stat5 is rapidly activated upon interaction of IL-2 and PRL with their respective receptors. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5706 | 10.4216 | 1.0000 | Activation of a second protein related to proteinStat1 was also observed. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1515 | 20.4377 | 0.9992 | Our results emphasize the role of PRL as a regulator of the immune response and indicate that the proteinStat factors mammary gland factor-Stat5 and Stat1 play a role in the regulation of gene expression during T cell development . |
| 1.7636 | 10.0207 | 1.0000 | Our results emphasize the role of proteinPRL as a regulator of the immune response and indicate that the Stat factors mammary gland factor-Stat5 and Stat1 play a role in the regulation of gene expression during T cell development . |
| 1.4829 | 0.9672 | 10.5983 | Our results emphasize the role of PRL as a regulator of the immune response and indicate that the Stat factors proteinmammary gland factor-Stat5 and Stat1 play a role in the regulation of gene expression during T cell development . |
| 0.9716 | 1.0000 | 1.0000 | Our results emphasize the role of PRL as a regulator of the immune response and indicate that the Stat factors mammary gland factor-Stat5 and proteinStat1 play a role in the regulation of gene expression during T cell development . |
| 0.9578 | 1.0000 | 1.0000 | Our results emphasize the role of PRL as a regulator of the immune response and indicate that the Stat factors mammary gland proteinfactor-Stat5 and Stat1 play a role in the regulation of gene expression during T cell development . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4554 | 20.3796 | 10.6144 | ETS1 transactivates the human GM-CSF promoter in cell_lineJurkat T cells stimulated with PMA and ionomycin . |
| 3.2372 | 20.6165 | 10.4266 | ETS1 transactivates the DNAhuman GM-CSF promoter in Jurkat T cells stimulated with PMA and ionomycin . |
| 0.9563 | 1.0000 | 1.0000 | proteinETS1 transactivates the human GM-CSF promoter in Jurkat T cells stimulated with PMA and ionomycin . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2575 | 20.9258 | 10.2718 | Activation of cell_typeT helper cells results in coordinate expression of a number of cytokines involved in differentiation , proliferation and activation of the haematopoietic system . |
| 1.6266 | 10.6609 | 1.0000 | Activation of T helper cells results in coordinate expression of a number of proteincytokines involved in differentiation , proliferation and activation of the haematopoietic system . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6245 | 10.1559 | 1.0000 | Granulocyte-macrophage colony-stimulating factor ( GM-CSF ) is one such proteincytokine whose increased expression results partly from increases in transcription . |
| 1.5840 | 0.9988 | 10.2136 | proteinGranulocyte-macrophage colony-stimulating factor ( GM-CSF ) is one such cytokine whose increased expression results partly from increases in transcription . |
| 0.9738 | 1.0000 | 1.0000 | Granulocyte-macrophage colony-stimulating factor ( proteinGM-CSF ) is one such cytokine whose increased expression results partly from increases in transcription . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5914 | 10.9495 | 0.9964 | Cis-acting elements with NF kappa B , AP-1 and ETS-like motifs have been identified in the promoter region of the proteinGM-CSF gene , which are important for transcriptional activity following PMA and ionomycin stimulation. |
| 1.5462 | 10.8773 | 1.0000 | Cis-acting elements with NF kappa B , AP-1 and ETS-like motifs have been identified in the promoter region of the DNAGM-CSF gene , which are important for transcriptional activity following PMA and ionomycin stimulation. |
| 0.8716 | 0.9991 | 0.9999 | DNACis-acting elements with NF kappa B , AP-1 and ETS-like motifs have been identified in the promoter region of the GM-CSF gene , which are important for transcriptional activity following PMA and ionomycin stimulation. |
| 1.5505 | 10.9563 | 0.9999 | Cis-acting elements with NF kappa B , AP-1 and ETS-like motifs have been identified in the DNApromoter region of the GM-CSF gene , which are important for transcriptional activity following PMA and ionomycin stimulation. |
| Cis-acting elements with NF kappa B , proteinAP-1 and ETS-like motifs have been identified in the promoter region of the GM-CSF gene , which are important for transcriptional activity following PMA and ionomycin stimulation. | |||
| Cis-acting elements with NF kappa B , AP-1 and DNAETS-like motifs have been identified in the promoter region of the GM-CSF gene , which are important for transcriptional activity following PMA and ionomycin stimulation. | |||
| Cis-acting elements with proteinNF kappa B , AP-1 and ETS-like motifs have been identified in the promoter region of the GM-CSF gene , which are important for transcriptional activity following PMA and ionomycin stimulation. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1717 | 20.4526 | 0.9999 | A number of the ETS family of transcription factors are expressed in cell_typeT cells , including ETS1 and ELF1 . |
| 1.9851 | 20.7249 | 0.9999 | A number of the proteinETS family of transcription factors are expressed in T cells , including ETS1 and ELF1 . |
| 1.6094 | 10.3253 | 1.0000 | A number of the ETS family of transcription factors are expressed in T cells , including proteinETS1 and ELF1 . |
| 1.4286 | 10.5914 | 0.9999 | A number of the ETS family of proteintranscription factors are expressed in T cells , including ETS1 and ELF1 . |
| 0.8826 | 1.0000 | 1.0000 | A number of the ETS family of transcription factors are expressed in T cells , including ETS1 and proteinELF1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9556 | 20.4645 | 10.9823 | Here we describe the ability of these factors to interact with a site ( GM5 ), located within the CLE0 element , -47 to -40 upstream of the DNAGM-CSF transcription initiation site . |
| 3.2292 | 10.7851 | 10.7600 | Here we describe the ability of these factors to interact with a site ( GM5 ), located within the CLE0 element , DNA-47 to -40 upstream of the GM-CSF transcription initiation site . |
| 2.1952 | 20.0053 | 0.9982 | Here we describe the ability of these factors to interact with a site ( GM5 ), located within the CLE0 element , -47 to -40 upstream of the proteinGM-CSF transcription initiation site . |
| 1.9744 | 20.0091 | 0.9999 | Here we describe the ability of these factors to interact with a site ( GM5 ), located within the DNACLE0 element , -47 to -40 upstream of the GM-CSF transcription initiation site . |
| 0.8714 | 1.0000 | 1.0000 | Here we describe the ability of these factors to interact with a site ( DNAGM5 ), located within the CLE0 element , -47 to -40 upstream of the GM-CSF transcription initiation site . |
| 1.9337 | 20.0458 | 0.9648 | Here we describe the ability of these factors to interact with a site ( GM5 ), located within the DNACLE0 element , -47 to -40 upstream of the GM-CSF transcription initiation site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2299 | 20.4570 | 0.9999 | Exogenous ETS1 , but not ELF1 , can transactivate GM-CSF , through the DNAGM5 site, in a PMA / ionomycin dependent manner . |
| 1.7467 | 10.0467 | 1.0000 | Exogenous proteinETS1 , but not ELF1 , can transactivate GM-CSF , through the GM5 site, in a PMA / ionomycin dependent manner . |
| 1.5964 | 10.7570 | 1.0000 | Exogenous ETS1 , but not proteinELF1 , can transactivate GM-CSF , through the GM5 site, in a PMA / ionomycin dependent manner . |
| 0.8518 | 1.0000 | 1.0000 | Exogenous ETS1 , but not ELF1 , can transactivate proteinGM-CSF , through the GM5 site, in a PMA / ionomycin dependent manner . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1694 | 20.0607 | 0.9999 | Other unidentified ETS-like factors present in cell_lineJurkat cells are also capable of binding GM5 . |
| 2.0480 | 20.6650 | 0.9999 | Other unidentified proteinETS-like factors present in Jurkat cells are also capable of binding GM5 . |
| Other unidentified ETS-like factors present in Jurkat cells are also capable of binding DNAGM5 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7082 | 20.6166 | 10.7403 | Mutation of the core DNAETS binding site from -GGAA- to -GGAT- prevents the binding of ETS-like factors with the exception of ETS1 . |
| 2.0515 | 20.7681 | 1.0000 | Mutation of the core ETS binding site from -GGAA- to -GGAT- prevents the binding of proteinETS-like factors with the exception of ETS1 . |
| 1.9258 | 20.1241 | 1.0000 | Mutation of the core ETS binding site from -GGAA- to -GGAT- prevents the binding of ETS-like factors with the exception of proteinETS1 . |
| Mutation of the core ETS binding site from DNA-GGAA- to -GGAT- prevents the binding of ETS-like factors with the exception of ETS1 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7555 | 10.4215 | 1.0000 | The GM-CSF promoter , modified in this way to be ETS1 specific , is fully responsive to PMA / ionomycin induction, in addition to proteinETS1 transactivation in the presence of PMA and ionomycin . |
| 1.6411 | 10.7578 | 1.0000 | The DNAGM-CSF promoter , modified in this way to be ETS1 specific , is fully responsive to PMA / ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin . |
| 1.5699 | 10.9293 | 0.9867 | The proteinGM-CSF promoter , modified in this way to be ETS1 specific , is fully responsive to PMA / ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin . |
| 0.9039 | 1.0000 | 1.0000 | The GM-CSF promoter , modified in this way to be proteinETS1 specific , is fully responsive to PMA / ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7598 | 10.3973 | 1.0000 | Together these data suggest that ETS1 may be involved in mediating the increased proteinGM-CSF production associated with T cell activation . |
| 1.6575 | 10.6637 | 1.0000 | Together these data suggest that proteinETS1 may be involved in mediating the increased GM-CSF production associated with T cell activation . |
| Together these data suggest that ETS1 may be involved in mediating the increased GM-CSF production associated with cell_typeT cell activation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9152 | 10.9988 | 10.8586 | Quantitation of proteinbeta 1 triiodothyronine receptor mRNA in human tissues by competitive reverse transcription polymerase chain reaction . |
| 1.6241 | 10.6766 | 0.9995 | Quantitation of RNAbeta 1 triiodothyronine receptor mRNA in human tissues by competitive reverse transcription polymerase chain reaction . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5129 | 20.3709 | 10.8045 | Thyroid hormones act by binding to proteinnuclear receptor proteins , the thyroid hormone receptors ( TR ) alpha and beta . |
| 1.8315 | 10.9957 | 10.5907 | Thyroid hormones act by binding to nuclear receptor proteins , the proteinthyroid hormone receptors ( TR ) alpha and beta . |
| 0.9075 | 1.0000 | 1.0000 | Thyroid hormones act by binding to nuclear receptor proteins , the thyroid hormone receptors ( proteinTR ) alpha and beta . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9446 | 1.0000 | 1.0000 | Data from cell culture and animal studies indicate that proteinTR expression may be regulated to modulate target organ responsiveness to thyroid hormone . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0077 | 20.4928 | 10.5133 | To investigate whether such adaptive changes in TR expression occur in humans, we determined the mRNA levels of the proteinhTR beta 1 in various thyroid states . |
| 1.7456 | 10.3908 | 1.0000 | To investigate whether such adaptive changes in proteinTR expression occur in humans, we determined the mRNA levels of the hTR beta 1 in various thyroid states . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2885 | 20.2464 | 10.8875 | Total RNA was isolated from cell_typeperipheral blood mononuclear cells and hTR beta 1 mRNA levels determined by quantitative competitive reverse transcription PCR . |
| 2.7697 | 20.6968 | 10.7563 | Total RNA was isolated from peripheral blood mononuclear cells and proteinhTR beta 1 mRNA levels determined by quantitative competitive reverse transcription PCR . |
| 2.4586 | 20.7683 | 0.9999 | Total RNA was isolated from peripheral blood mononuclear cells and RNAhTR beta 1 mRNA levels determined by quantitative competitive reverse transcription PCR . |
| 0.8528 | 0.9995 | 1.0000 | Total RNARNA was isolated from peripheral blood mononuclear cells and hTR beta 1 mRNA levels determined by quantitative competitive reverse transcription PCR . |
| RNATotal RNA was isolated from peripheral blood mononuclear cells and hTR beta 1 mRNA levels determined by quantitative competitive reverse transcription PCR . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3778 | 20.4519 | 10.6062 | For comparison, proteinhTR beta 1 mRNA levels were determined in lymphocytes and normal thyroid tissue of euthyroid patients . |
| 2.3773 | 20.3171 | 0.9997 | For comparison, RNAhTR beta 1 mRNA levels were determined in lymphocytes and normal thyroid tissue of euthyroid patients . |
| 1.6722 | 10.1168 | 1.0000 | For comparison, hTR beta 1 mRNA levels were determined in cell_typelymphocytes and normal thyroid tissue of euthyroid patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7077 | 10.4939 | 1.0000 | Human TR beta 1 mRNA levels in cell_typelymphocytes were 1.8 +/- 0.4, 1.9 +/- 0.5, 1.1 +/- 0.4 10(-18) mol/microgram RNA in hypo -, eu -and hyper thyroid patients , respectively, corresponding to an estimated 0.5 -2 molecules per cell. |
| 1.7064 | 0.9995 | 10.7002 | proteinHuman TR beta 1 mRNA levels in lymphocytes were 1.8 +/- 0.4, 1.9 +/- 0.5, 1.1 +/- 0.4 10(-18) mol/microgram RNA in hypo -, eu -and hyper thyroid patients , respectively, corresponding to an estimated 0.5 -2 molecules per cell. |
| 0.8183 | 0.9903 | 0.9982 | RNAHuman TR beta 1 mRNA levels in lymphocytes were 1.8 +/- 0.4, 1.9 +/- 0.5, 1.1 +/- 0.4 10(-18) mol/microgram RNA in hypo -, eu -and hyper thyroid patients , respectively, corresponding to an estimated 0.5 -2 molecules per cell. |
| 0.8588 | 0.9998 | 1.0000 | Human TR beta 1 mRNA levels in lymphocytes were 1.8 +/- 0.4, 1.9 +/- 0.5, 1.1 +/- 0.4 10(-18) mol/microgram RNARNA in hypo -, eu -and hyper thyroid patients , respectively, corresponding to an estimated 0.5 -2 molecules per cell. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5815 | 20.6008 | 10.8226 | Although the mean proteinhTR beta 1 mRNA levels were 40% lower in hyperthyroid than in euthyroid subjects, this difference did not reach statistical significance . |
| 2.4310 | 20.7290 | 0.9998 | Although the mean RNAhTR beta 1 mRNA levels were 40% lower in hyperthyroid than in euthyroid subjects, this difference did not reach statistical significance . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3587 | 20.9945 | 10.7661 | Similar levels of proteinhTR beta 1 mRNA levels were detected in thyroid gland from euthyroid patients . |
| 2.2863 | 20.9049 | 0.9999 | Similar levels of RNAhTR beta 1 mRNA levels were detected in thyroid gland from euthyroid patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7193 | 20.8373 | 10.9811 | In summary, we developed an assay for the quantitative determination of proteinhTR beta 1 mRNA levels in small human tissue samples , containing as little as 50 ng of total RNA. |
| 2.4590 | 20.8313 | 0.9999 | In summary, we developed an assay for the quantitative determination of RNAhTR beta 1 mRNA levels in small human tissue samples , containing as little as 50 ng of total RNA. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2523 | 20.9302 | 10.9724 | Absolute hTR beta 1 mRNA levels are very low with an estimated one molecule of mRNA being present in a cell_typemononuclear blood cell or thyrocyte . |
| 3.5243 | 10.8234 | 20.2076 | Absolute RNAhTR beta 1 mRNA levels are very low with an estimated one molecule of mRNA being present in a mononuclear blood cell or thyrocyte . |
| 1.7191 | 10.0082 | 0.9999 | Absolute hTR beta 1 mRNA levels are very low with an estimated one molecule of mRNA being present in a mononuclear blood cell or cell_typethyrocyte . |
| 1.6780 | 10.7857 | 1.0000 | Absolute hTR beta 1 mRNA levels are very low with an estimated one molecule of RNAmRNA being present in a mononuclear blood cell or thyrocyte . |
| 1.2644 | 0.9959 | 10.1076 | Absolute proteinhTR beta 1 mRNA levels are very low with an estimated one molecule of mRNA being present in a mononuclear blood cell or thyrocyte . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8460 | 20.5841 | 10.6886 | No up-regulation of proteinhTR beta 1 was seen in hypothyroid relative to euthyroid patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6607 | 20.6143 | 10.9392 | However, there is a non-significant trend towards a down-regulation of proteinhTR beta 1 mRNA levels in hyperthyroid patients . |
| 2.3983 | 20.4763 | 0.9999 | However, there is a non-significant trend towards a down-regulation of RNAhTR beta 1 mRNA levels in hyperthyroid patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.9317 | 20.9620 | 20.5675 | Multiple proteins interact with the DNAnuclear inhibitory protein repressor element in the human interleukin-3 promoter . |
| 3.6220 | 30.9054 | 10.4047 | Multiple proteins interact with the nuclear inhibitory protein repressor element in the DNAhuman interleukin-3 promoter . |
| Multiple proteinproteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6701 | 20.8957 | 10.4465 | T cell expression of interleukin 3 ( IL-3 ) is directed by positive and negative cis-acting DNA elements clustered within 300 base pairs of the DNAtranscriptional start site . |
| 2.3257 | 20.8363 | 1.0000 | T cell expression of proteininterleukin 3 ( IL-3 ) is directed by positive and negative cis-acting DNA elements clustered within 300 base pairs of the transcriptional start site . |
| 0.9786 | 1.0000 | 1.0000 | T cell expression of interleukin 3 ( proteinIL-3 ) is directed by positive and negative cis-acting DNA elements clustered within 300 base pairs of the transcriptional start site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6539 | 30.4434 | 10.8456 | A strong repressor element , termed proteinnuclear inhibitory protein ( NIP ), was previously mapped to a segment of the IL-3 promoter between nucleotides -271 and -250 . |
| 3.0543 | 10.2493 | 20.0980 | A strong repressor element , termed nuclear inhibitory protein ( NIP ), was previously mapped to a segment of the IL-3 promoter between DNAnucleotides -271 and -250 . |
| 1.9696 | 20.7445 | 0.9998 | A strong repressor element , termed nuclear inhibitory protein ( NIP ), was previously mapped to a segment of the DNAIL-3 promoter between nucleotides -271 and -250 . |
| 0.9692 | 1.0000 | 1.0000 | A strong repressor element , termed nuclear inhibitory protein ( proteinNIP ), was previously mapped to a segment of the IL-3 promoter between nucleotides -271 and -250 . |
| 1.9222 | 20.7431 | 0.9601 | A strong repressor element , termed nuclear inhibitory protein ( NIP ), was previously mapped to a segment of the proteinIL-3 promoter between nucleotides -271 and -250 . |
| A strong proteinrepressor element , termed nuclear inhibitory protein ( NIP ), was previously mapped to a segment of the IL-3 promoter between nucleotides -271 and -250 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3840 | 20.1438 | 0.9999 | Functional characterization of this element demonstrates that it can mediate repression when linked in cis to a DNAheterologous promoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4959 | 20.0975 | 1.0000 | Using varying conditions, three distinct complexes were shown to interact specifically with the DNANIP region , although only one correlates with repressor activity . |
| Using varying conditions, three distinct complexes were shown to interact specifically with the proteinNIP region , although only one correlates with repressor activity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4200 | 20.2636 | 1.0000 | Complex 1 results from binding of a ubiquitous polypeptide that recognizes the DNA3' portion of this sequence and is not required for repression . |
| 0.9202 | 1.0000 | 1.0000 | proteinComplex 1 results from binding of a ubiquitous polypeptide that recognizes the 3' portion of this sequence and is not required for repression . |
| 1.4138 | 10.9255 | 0.9999 | Complex 1 results from binding of a proteinubiquitous polypeptide that recognizes the 3' portion of this sequence and is not required for repression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6304 | 20.5629 | 10.3535 | Complex 2 corresponds to binding of transcription factor ( proteinupstream stimulatory factor ) to an E-box motif in the 5' portion of the NIP region . |
| 2.1181 | 20.4177 | 0.9999 | Complex 2 corresponds to binding of transcription factor ( upstream stimulatory factor ) to an E-box motif in the DNA5' portion of the NIP region . |
| 2.1030 | 20.1423 | 0.9998 | Complex 2 corresponds to binding of transcription factor ( upstream stimulatory factor ) to an E-box motif in the 5' portion of the DNANIP region . |
| 2.0533 | 20.5511 | 0.9999 | Complex 2 corresponds to binding of transcription factor ( upstream stimulatory factor ) to an DNAE-box motif in the 5' portion of the NIP region . |
| 2.0315 | 20.1871 | 0.9999 | Complex 2 corresponds to binding of proteintranscription factor ( upstream stimulatory factor ) to an E-box motif in the 5' portion of the NIP region . |
| 0.8011 | 1.0000 | 1.0000 | proteinComplex 2 corresponds to binding of transcription factor ( upstream stimulatory factor ) to an E-box motif in the 5' portion of the NIP region . |
| Complex 2 corresponds to binding of transcription factor ( upstream stimulatory factor ) to an E-box motif in the 5' portion of the proteinNIP region . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5619 | 20.2756 | 10.4278 | DNA binding specificity of complex 3 overlaps with that of proteinupstream stimulatory factor but is clearly distinct. |
| 2.1825 | 20.2988 | 1.0000 | DNA binding specificity of proteincomplex 3 overlaps with that of upstream stimulatory factor but is clearly distinct. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1528 | 20.5854 | 10.7098 | To determine which of the latter two complexes represents NIP activity , we incorporated small alterations into the NIP site of an DNAIL-3 promoter -linked reporter construct and examined their effects on NIP -mediated repression . |
| 2.1826 | 20.3967 | 0.9999 | To determine which of the latter two complexes represents NIP activity , we incorporated small alterations into the DNANIP site of an IL-3 promoter -linked reporter construct and examined their effects on NIP -mediated repression . |
| 2.0144 | 20.4688 | 0.9814 | To determine which of the latter two complexes represents NIP activity , we incorporated small alterations into the NIP site of an DNAIL-3 promoter -linked reporter construct and examined their effects on NIP -mediated repression . |
| 1.6028 | 10.2047 | 1.0000 | To determine which of the latter two complexes represents proteinNIP activity , we incorporated small alterations into the NIP site of an IL-3 promoter -linked reporter construct and examined their effects on NIP -mediated repression . |
| 0.8614 | 1.0000 | 1.0000 | To determine which of the latter two complexes represents NIP activity , we incorporated small alterations into the NIP site of an IL-3 promoter -linked reporter construct and examined their effects on proteinNIP -mediated repression . |
| 1.9046 | 20.6096 | 0.9791 | To determine which of the latter two complexes represents NIP activity , we incorporated small alterations into the NIP site of an proteinIL-3 promoter -linked reporter construct and examined their effects on NIP -mediated repression . |
| To determine which of the latter two complexes represents NIP activity , we incorporated small alterations into the proteinNIP site of an IL-3 promoter -linked reporter construct and examined their effects on NIP -mediated repression . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2998 | 20.3573 | 1.0000 | Functional specificity for repression matches the DNA binding specificity of proteincomplex 3 ; both repressor activity and complex 3 binding require the consensus sequence CTCACNTNC . |
| 2.2907 | 20.2520 | 1.0000 | Functional specificity for repression matches the DNA binding specificity of complex 3 ; both repressor activity and proteincomplex 3 binding require the consensus sequence CTCACNTNC . |
| 2.1928 | 20.8914 | 0.9990 | Functional specificity for repression matches the DNA binding specificity of complex 3 ; both repressor activity and complex 3 binding require the DNAconsensus sequence CTCACNTNC . |
| 0.7903 | 0.9999 | 0.9999 | Functional specificity for repression matches the DNA binding specificity of complex 3 ; both repressor activity and complex 3 binding require the consensus sequence DNACTCACNTNC . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.7626 | 30.2915 | 20.7020 | The hematopoietic transcription factor PU.1 is downregulated in cell_linehuman multiple myeloma cell lines . |
| 1.8730 | 10.9436 | 10.0474 | The proteinhematopoietic transcription factor PU.1 is downregulated in human multiple myeloma cell lines . |
| 0.9436 | 0.9998 | 1.0000 | The hematopoietic transcription factor proteinPU.1 is downregulated in human multiple myeloma cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1776 | 20.0414 | 10.8303 | PU.1 is a proteinhematopoietic transcription factor belonging to the Ets-family . |
| 1.2394 | 10.3424 | 1.0000 | PU.1 is a hematopoietic transcription factor belonging to the proteinEts-family . |
| 0.9661 | 1.0000 | 1.0000 | proteinPU.1 is a hematopoietic transcription factor belonging to the Ets-family . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5012 | 10.8838 | 1.0000 | It is identical to the DNASpi-1 oncogene , which is implicated in spleen focus-forming virus-induced murine erythroleukemias . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5984 | 10.9074 | 1.0000 | PU.1 seems to be required for early development of multiple hematopoietic lineages , but its expression in cell_typemature cells is preferentially observed in cells of the B-cell-and monocyte/macrophage- differentiation lineage . |
| 0.9787 | 1.0000 | 1.0000 | proteinPU.1 seems to be required for early development of multiple hematopoietic lineages , but its expression in mature cells is preferentially observed in cells of the B-cell-and monocyte/macrophage- differentiation lineage . |
| 2.4114 | 20.1232 | 1.0000 | PU.1 seems to be required for early development of multiple cell_typehematopoietic lineages , but its expression in mature cells is preferentially observed in cells of the B-cell-and monocyte/macrophage- differentiation lineage . |
| PU.1 seems to be required for early development of cell_typemultiple hematopoietic lineages , but its expression in mature cells is preferentially observed in cells of the B-cell-and monocyte/macrophage- differentiation lineage . | |||
| PU.1 seems to be required for early development of multiple hematopoietic lineages , but its expression in mature cells is preferentially observed in cells of the cell_typeB-cell-and monocyte/macrophage- differentiation lineage . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6427 | 20.8553 | 10.9522 | It binds the so-called Pu box , an important DNAtissue-specific regulatory DNA element present in a number of genes expressed in these cell lineages . |
| 2.1249 | 20.2809 | 1.0000 | It binds the so-called DNAPu box , an important tissue-specific regulatory DNA element present in a number of genes expressed in these cell lineages . |
| 1.7646 | 10.6316 | 10.2259 | It binds the so-called Pu box , an important tissue-specific regulatory DNA element present in a number of genes expressed in these cell_typecell lineages . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3322 | 20.4895 | 1.0000 | We have analyzed the expression and activity of PU.1 during human B-cell development using a panel of cell_lineB-cell lines representing different stages of maturation, from early precursors to differentiated plasma cells . |
| 1.7059 | 10.2289 | 1.0000 | We have analyzed the expression and activity of proteinPU.1 during human B-cell development using a panel of B-cell lines representing different stages of maturation, from early precursors to differentiated plasma cells . |
| 3.0182 | 10.6129 | 10.7660 | We have analyzed the expression and activity of PU.1 during human B-cell development using a panel of B-cell lines representing different stages of maturation, from early precursors to cell_typedifferentiated plasma cells . |
| 1.4848 | 10.6696 | 0.9994 | We have analyzed the expression and activity of PU.1 during human B-cell development using a panel of B-cell lines representing different stages of maturation, from cell_typeearly precursors to differentiated plasma cells . |
| We have analyzed the expression and activity of PU.1 during human B-cell development using a panel of B-cell lines representing different stages of maturation, from early precursors to cell_linedifferentiated plasma cells . | |||
| We have analyzed the expression and activity of PU.1 during human B-cell development using a panel of B-cell lines representing different stages of maturation, from cell_lineearly precursors to differentiated plasma cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7767 | 10.4157 | 1.0000 | PU.1 mRNA expression and proteinPU.1 DNA binding activity , as measured by Northern blot analysis and electrophoretic mobility shift assay , respectively, were evident in cell lines representing pro-B , pre-B , and mature B cells . |
| 1.5882 | 10.8070 | 1.0000 | PU.1 mRNA expression and PU.1 DNA binding activity , as measured by Northern blot analysis and electrophoretic mobility shift assay , respectively, were evident in cell_linecell lines representing pro-B , pre-B , and mature B cells . |
| 0.9449 | 0.9995 | 1.0000 | RNAPU.1 mRNA expression and PU.1 DNA binding activity , as measured by Northern blot analysis and electrophoretic mobility shift assay , respectively, were evident in cell lines representing pro-B , pre-B , and mature B cells . |
| 0.8735 | 1.0000 | 0.9929 | proteinPU.1 mRNA expression and PU.1 DNA binding activity , as measured by Northern blot analysis and electrophoretic mobility shift assay , respectively, were evident in cell lines representing pro-B , pre-B , and mature B cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3209 | 20.3896 | 0.9998 | We could also show Pu box -dependent transactivation of a reporter gene in transient transfections in these cell_linecell lines . |
| 2.3116 | 20.5867 | 0.9999 | We could also show DNAPu box -dependent transactivation of a reporter gene in transient transfections in these cell lines . |
| 2.2498 | 20.5143 | 1.0000 | We could also show Pu box -dependent transactivation of a DNAreporter gene in transient transfections in these cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.3025 | 30.4197 | 20.3585 | In contrast, in a number of multiple myeloma cell lines , representing cell_typedifferentiated, plasma cell-like B cells , PU.1 DNA binding activity , mRNA expression , and Pu box -dependent transactivation were absent or detectable at a very low level. |
| 4.5542 | 20.7285 | 10.4974 | In contrast, in a number of cell_linemultiple myeloma cell lines , representing differentiated, plasma cell-like B cells , PU.1 DNA binding activity , mRNA expression , and Pu box -dependent transactivation were absent or detectable at a very low level. |
| 1.9719 | 20.2615 | 0.9999 | In contrast, in a number of multiple myeloma cell lines , representing differentiated, plasma cell-like B cells , PU.1 DNA binding activity , mRNA expression , and DNAPu box -dependent transactivation were absent or detectable at a very low level. |
| 0.9580 | 1.0000 | 1.0000 | In contrast, in a number of multiple myeloma cell lines , representing differentiated, plasma cell-like B cells , proteinPU.1 DNA binding activity , mRNA expression , and Pu box -dependent transactivation were absent or detectable at a very low level. |
| 1.1704 | 0.9999 | 10.8633 | In contrast, in a number of multiple myeloma cell lines , representing differentiated, cell_typeplasma cell-like B cells , PU.1 DNA binding activity , mRNA expression , and Pu box -dependent transactivation were absent or detectable at a very low level. |
| 0.6279 | 0.9965 | 0.9996 | In contrast, in a number of multiple myeloma cell lines , representing differentiated, plasma cell-like cell_typeB cells , PU.1 DNA binding activity , mRNA expression , and Pu box -dependent transactivation were absent or detectable at a very low level. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2644 | 10.8325 | 10.6183 | In cell_linelymphoblastoid cell lines , which exemplify an intermediate stage of B-cell differentiation , a reduced expression and activity were observed. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.2375 | 30.8282 | 20.5032 | The findings in the cell_linehuman multiple myeloma cell lines represent the first examples of B cells with downregulated PU.1 expression and apparently contradict observations in the murine system in which PU.1 is expressed and active in plasmacytoma cell lines . |
| 3.5516 | 20.5279 | 10.7551 | The findings in the human multiple myeloma cell lines represent the first examples of B cells with downregulated PU.1 expression and apparently contradict observations in the murine system in which PU.1 is expressed and active in cell_lineplasmacytoma cell lines . |
| 2.1852 | 20.2221 | 0.9999 | The findings in the human multiple myeloma cell lines represent the first examples of cell_typeB cells with downregulated PU.1 expression and apparently contradict observations in the murine system in which PU.1 is expressed and active in plasmacytoma cell lines . |
| 1.6364 | 10.4367 | 1.0000 | The findings in the human multiple myeloma cell lines represent the first examples of B cells with downregulated proteinPU.1 expression and apparently contradict observations in the murine system in which PU.1 is expressed and active in plasmacytoma cell lines . |
| 0.8663 | 1.0000 | 1.0000 | The findings in the human multiple myeloma cell lines represent the first examples of B cells with downregulated PU.1 expression and apparently contradict observations in the murine system in which proteinPU.1 is expressed and active in plasmacytoma cell lines . |
| The findings in the human cell_linemultiple myeloma cell lines represent the first examples of B cells with downregulated PU.1 expression and apparently contradict observations in the murine system in which PU.1 is expressed and active in plasmacytoma cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.6367 | 20.8431 | 20.1368 | At present, it is unclear whether the lack of PU.1 expression and activity in cell_linehuman multiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in terminally differentiated B cells . |
| 3.7622 | 20.5554 | 10.9244 | At present, it is unclear whether the lack of PU.1 expression and activity in human multiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in cell_typeterminally differentiated B cells . |
| 1.5204 | 10.3498 | 1.0000 | At present, it is unclear whether the lack of proteinPU.1 expression and activity in human multiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in terminally differentiated B cells . |
| 1.4938 | 0.9999 | 10.0650 | At present, it is unclear whether the lack of PU.1 expression and activity in human multiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in terminally differentiated cell_typeB cells . |
| At present, it is unclear whether the lack of PU.1 expression and activity in human cell_linemultiple myeloma cell lines represents a malignancy-associated defect in these cells or exemplifies a normal developmental regulation in terminally differentiated B cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0493 | 20.8367 | 10.9951 | Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the proteinT-cell transcription factor NFAT . |
| 4.0247 | 20.5599 | 10.9046 | Regulation of proteingranulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT . |
| 1.3879 | 10.5929 | 0.9999 | Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in cell_typeendothelial cells by cyclosporin A and the T-cell transcription factor NFAT . |
| 0.9528 | 0.9999 | 0.9999 | Regulation of granulocyte-macrophage colony-stimulating factor and E-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor proteinNFAT . |
| 0.9106 | 1.0000 | 1.0000 | Regulation of granulocyte-macrophage colony-stimulating factor and proteinE-selectin expression in endothelial cells by cyclosporin A and the T-cell transcription factor NFAT . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9280 | 30.1450 | 10.3180 | Nuclear factor of activated T cells ( NFAT ) was originally described as a proteinT-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A ( CsA ). |
| 2.5989 | 0.9988 | 20.2860 | proteinNuclear factor of activated T cells ( NFAT ) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A ( CsA ). |
| 0.9842 | 1.0000 | 1.0000 | Nuclear factor of activated T cells ( proteinNFAT ) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the immunoregulatory effects of cyclosporin A ( CsA ). |
| 0.7943 | 0.9998 | 1.0000 | Nuclear factor of activated T cells ( NFAT ) was originally described as a T-cell-specific transcription factor athat supported the activation of cytokine gene expression and mediated the proteinimmunoregulatory effects of cyclosporin A ( CsA ). |
| 1.2550 | 10.9427 | 0.9998 | Nuclear factor of activated T cells ( NFAT ) was originally described as a T-cell-specific transcription factor athat supported the activation of DNAcytokine gene expression and mediated the immunoregulatory effects of cyclosporin A ( CsA ). |
| Nuclear factor of activated T cells ( NFAT ) was originally described as a T-cell-specific transcription factor athat supported the activation of proteincytokine gene expression and mediated the immunoregulatory effects of cyclosporin A ( CsA ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2132 | 20.5410 | 0.9998 | As we observed that activated endothelial cells also expressed NFAT , we tested the antiinflammatory properties of CsA in cell_typeendothelial cells . |
| 1.6813 | 10.4544 | 1.0000 | As we observed that activated endothelial cells also expressed proteinNFAT , we tested the antiinflammatory properties of CsA in endothelial cells . |
| 2.2620 | 20.1633 | 0.9999 | As we observed that activated cell_typeendothelial cells also expressed NFAT , we tested the antiinflammatory properties of CsA in endothelial cells . |
| As we observed that cell_typeactivated endothelial cells also expressed NFAT , we tested the antiinflammatory properties of CsA in endothelial cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.7470 | 30.2281 | 20.9086 | Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of DNAgranulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene regulatory elements that use NFAT by 60%. |
| 3.6928 | 30.9553 | 10.5514 | Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of proteingranulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene regulatory elements that use NFAT by 60%. |
| 1.3192 | 10.2259 | 1.0000 | Significantly, CsA completely suppressed the induction of proteinNFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene regulatory elements that use NFAT by 60%. |
| 1.1846 | 10.2367 | 0.9997 | Significantly, CsA completely suppressed the induction of NFAT in cell_typeendothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene regulatory elements that use NFAT by 60%. |
| 0.9505 | 1.0000 | 0.9976 | Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor ( proteinGM-CSF ) gene regulatory elements that use NFAT by 60%. |
| 0.6833 | 0.9997 | 1.0000 | Significantly, CsA completely suppressed the induction of NFAT in endothelial cells and inhibited the activity of granulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene regulatory elements that use proteinNFAT by 60%. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4945 | 20.1560 | 1.0000 | CsA similarly mediated a reduction of up to 65% in RNAGM-CSF mRNA and protein expression in activated endothelial cells . |
| 2.0461 | 20.3495 | 0.9938 | CsA similarly mediated a reduction of up to 65% in proteinGM-CSF mRNA and protein expression in activated endothelial cells . |
| 0.7892 | 0.9993 | 0.9998 | CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in activated cell_typeendothelial cells . |
| CsA similarly mediated a reduction of up to 65% in GM-CSF mRNA and protein expression in cell_typeactivated endothelial cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4532 | 20.9296 | 10.7071 | CsA also suppressed E-selectin , but not proteinvascular cell adhesion molecule-1 ( VCAM-1 ) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT . |
| 2.0931 | 20.2995 | 1.0000 | CsA also suppressed E-selectin , but not vascular cell adhesion molecule-1 ( VCAM-1 ) expression in endothelial cells, even though the E-selectin promoter is activated by proteinNF-kappa B rather than NFAT . |
| 2.0216 | 20.3117 | 0.9924 | CsA also suppressed E-selectin , but not vascular cell adhesion molecule-1 ( VCAM-1 ) expression in endothelial cells, even though the proteinE-selectin promoter is activated by NF-kappa B rather than NFAT . |
| 1.9960 | 20.3299 | 1.0000 | CsA also suppressed E-selectin , but not vascular cell adhesion molecule-1 ( VCAM-1 ) expression in endothelial cells, even though the DNAE-selectin promoter is activated by NF-kappa B rather than NFAT . |
| 1.4791 | 10.4305 | 1.0000 | CsA also suppressed E-selectin , but not vascular cell adhesion molecule-1 ( VCAM-1 ) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than proteinNFAT . |
| 0.9619 | 1.0000 | 1.0000 | CsA also suppressed E-selectin , but not vascular cell adhesion molecule-1 ( proteinVCAM-1 ) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT . |
| 0.8737 | 0.9999 | 1.0000 | CsA also suppressed proteinE-selectin , but not vascular cell adhesion molecule-1 ( VCAM-1 ) expression in endothelial cells, even though the E-selectin promoter is activated by NF-kappa B rather than NFAT . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3710 | 20.6890 | 10.6221 | Hence, induction of cell surface expression of this proteinleukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA , and this was reflected by a 29% decrease in neutrophil adhesion . |
| 4.2192 | 20.9148 | 10.7554 | Hence, induction of cell surface expression of this leukocyte adhesion molecule by proteintumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA , and this was reflected by a 29% decrease in neutrophil adhesion . |
| 0.8012 | 0.9998 | 0.9999 | Hence, induction of cell surface expression of this leukocyte adhesion molecule by tumor necrosis factor (TNF)-alpha was reduced by 40% in the presence of CsA , and this was reflected by a 29% decrease in cell_typeneutrophil adhesion . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6103 | 20.2154 | 10.8259 | The effects of CsA on endothelial cells were also detected at the chromatin structure level , as DNADNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA . |
| 1.4773 | 10.9940 | 0.9999 | The effects of CsA on endothelial cells were also detected at the chromatin structure level , as DNasel hypersensitive sites within both the GM-CSF enhancer and the DNAE-selectin promoter were suppressed by CsA . |
| 1.4389 | 10.8612 | 0.9999 | The effects of CsA on cell_typeendothelial cells were also detected at the chromatin structure level , as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA . |
| 1.3946 | 10.8404 | 0.9912 | The effects of CsA on endothelial cells were also detected at the chromatin structure level , as DNasel hypersensitive sites within both the proteinGM-CSF enhancer and the E-selectin promoter were suppressed by CsA . |
| 1.4502 | 10.7521 | 0.9999 | The effects of CsA on endothelial cells were also detected at the DNAchromatin structure level , as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA . |
| 1.4404 | 10.9660 | 1.0000 | The effects of CsA on endothelial cells were also detected at the chromatin structure level , as DNasel hypersensitive sites within both the DNAGM-CSF enhancer and the E-selectin promoter were suppressed by CsA . |
| The effects of CsA on endothelial cells were also detected at the chromatin structure level , as DNasel hypersensitive sites within both the GM-CSF enhancer and the proteinE-selectin promoter were suppressed by CsA . | |||
| The effects of CsA on endothelial cells were also detected at the DNAchromatin structure level , as DNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA . | |||
| The effects of CsA on endothelial cells were also detected at the chromatin structure level , as proteinDNasel hypersensitive sites within both the GM-CSF enhancer and the E-selectin promoter were suppressed by CsA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6437 | 10.7880 | 1.0000 | This represents the first report of proteinNFAT in endothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent . |
| 1.6288 | 10.4434 | 0.9999 | This represents the first report of NFAT in cell_typeendothelial cells and suggests mechanisms by which CsA could function as an antiinflammatory agent . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5667 | 10.0853 | 1.0000 | Costimulation requirement for proteinAP-1 and NF-kappa B transcription factor activation in T cells . |
| 1.3977 | 10.8478 | 0.9993 | Costimulation requirement for AP-1 and NF-kappa B transcription factor activation in cell_typeT cells . |
| 1.3805 | 10.4122 | 0.9995 | Costimulation requirement for AP-1 and proteinNF-kappa B transcription factor activation in T cells . |
| 0.8318 | 0.9870 | 0.9999 | Costimulation requirement for AP-1 and NF-kappa B proteintranscription factor activation in T cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1251 | 20.1953 | 1.0000 | The transcriptional activity of the DNAIL-2 promoter requires T-cell costimulation delivered by the TCR and the auxiliary receptor CD28 . |
| 1.9955 | 20.0791 | 0.9909 | The transcriptional activity of the proteinIL-2 promoter requires T-cell costimulation delivered by the TCR and the auxiliary receptor CD28 . |
| 0.8784 | 1.0000 | 1.0000 | The transcriptional activity of the IL-2 promoter requires T-cell costimulation delivered by the proteinTCR and the auxiliary receptor CD28 . |
| 1.3539 | 10.5176 | 0.9994 | The transcriptional activity of the IL-2 promoter requires T-cell costimulation delivered by the TCR and the proteinauxiliary receptor CD28 . |
| 0.9717 | 0.9999 | 1.0000 | The transcriptional activity of the IL-2 promoter requires T-cell costimulation delivered by the TCR and the auxiliary receptor proteinCD28 . |
| The transcriptional activity of the IL-2 promoter requires T-cell costimulation delivered by the TCR and the proteinauxiliary receptor CD28 . | |||
| The transcriptional activity of the IL-2 promoter requires cell_typeT-cell costimulation delivered by the TCR and the auxiliary receptor CD28 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6609 | 20.8542 | 10.8056 | Several transcription factors participate in IL-2 promoter activation , among which are proteinAP-1 -like factors and NF-kappa B . |
| 1.8674 | 20.3726 | 0.9952 | Several transcription factors participate in IL-2 promoter activation , among which are proteinAP-1 -like factors and NF-kappa B . |
| 1.8553 | 20.3371 | 0.9866 | Several transcription factors participate in proteinIL-2 promoter activation , among which are AP-1 -like factors and NF-kappa B . |
| 1.4651 | 10.9635 | 0.9998 | Several transcription factors participate in IL-2 promoter activation , among which are AP-1 -like factors and proteinNF-kappa B . |
| 1.3985 | 10.7834 | 0.9999 | Several proteintranscription factors participate in IL-2 promoter activation , among which are AP-1 -like factors and NF-kappa B . |
| 2.0227 | 20.3440 | 0.9999 | Several transcription factors participate in DNAIL-2 promoter activation , among which are AP-1 -like factors and NF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4208 | 10.3687 | 10.3042 | Protein phosphorylation has an important role in the regulation of these two factors: (1) it induces the transactivating capacity of the AP-1 protein c-Jun ; and (2) it is involved in the release of the cytoplasmic inhibitor , proteinI kappa B , from NF-kappa B , allowing translocation of the latter into the nucleus . |
| 2.3753 | 20.0637 | 1.0000 | Protein phosphorylation has an important role in the regulation of these two factors: (1) it induces the transactivating capacity of the AP-1 protein c-Jun ; and (2) it is involved in the release of the cytoplasmic inhibitor , I kappa B , from proteinNF-kappa B , allowing translocation of the latter into the nucleus . |
| 2.1408 | 20.5297 | 0.9977 | Protein phosphorylation has an important role in the regulation of these two factors: (1) it induces the transactivating capacity of the proteinAP-1 protein c-Jun ; and (2) it is involved in the release of the cytoplasmic inhibitor , I kappa B , from NF-kappa B , allowing translocation of the latter into the nucleus . |
| 1.5304 | 10.7542 | 1.0000 | Protein phosphorylation has an important role in the regulation of these two factors: (1) it induces the transactivating capacity of the AP-1 protein c-Jun ; and (2) it is involved in the release of the proteincytoplasmic inhibitor , I kappa B , from NF-kappa B , allowing translocation of the latter into the nucleus . |
| 0.9916 | 1.0000 | 1.0000 | Protein phosphorylation has an important role in the regulation of these two factors: (1) it induces the transactivating capacity of the AP-1 protein proteinc-Jun ; and (2) it is involved in the release of the cytoplasmic inhibitor , I kappa B , from NF-kappa B , allowing translocation of the latter into the nucleus . |
| 2.0502 | 20.6590 | 0.9899 | Protein phosphorylation has an important role in the regulation of these two factors: (1) it induces the transactivating capacity of the proteinAP-1 protein c-Jun ; and (2) it is involved in the release of the cytoplasmic inhibitor , I kappa B , from NF-kappa B , allowing translocation of the latter into the nucleus . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5093 | 20.2621 | 10.6890 | Furthermore, in cell_typeactivated T cells , the kinetics of the two phosphorylation events are essentially similar. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7570 | 10.0807 | 1.0000 | According to our results, however, the proteinkinases responsible for the two processes are distinct entities. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6819 | 20.8548 | 10.3915 | Whereas TPCK inhibits phosphorylation of I kappa B and, consequently, activation of NF-kappa B , it markedly enhances the activity of JNK , the proteinMAP kinase-related kinase that phosphorylates the transactivation domain of c-Jun . |
| 3.5194 | 20.9114 | 10.6684 | Whereas TPCK inhibits phosphorylation of proteinI kappa B and, consequently, activation of NF-kappa B , it markedly enhances the activity of JNK , the MAP kinase-related kinase that phosphorylates the transactivation domain of c-Jun . |
| 2.1525 | 20.3587 | 1.0000 | Whereas TPCK inhibits phosphorylation of I kappa B and, consequently, activation of proteinNF-kappa B , it markedly enhances the activity of JNK , the MAP kinase-related kinase that phosphorylates the transactivation domain of c-Jun . |
| 2.0440 | 20.7681 | 0.9999 | Whereas TPCK inhibits phosphorylation of I kappa B and, consequently, activation of NF-kappa B , it markedly enhances the activity of JNK , the MAP kinase-related kinase that phosphorylates the proteintransactivation domain of c-Jun . |
| 1.5428 | 10.0605 | 1.0000 | Whereas TPCK inhibits phosphorylation of I kappa B and, consequently, activation of NF-kappa B , it markedly enhances the activity of JNK , the MAP kinase-related kinase that phosphorylates the transactivation domain of proteinc-Jun . |
| 1.5028 | 10.6324 | 1.0000 | Whereas TPCK inhibits phosphorylation of I kappa B and, consequently, activation of NF-kappa B , it markedly enhances the activity of proteinJNK , the MAP kinase-related kinase that phosphorylates the transactivation domain of c-Jun . |
| Whereas proteinTPCK inhibits phosphorylation of I kappa B and, consequently, activation of NF-kappa B , it markedly enhances the activity of JNK , the MAP kinase-related kinase that phosphorylates the transactivation domain of c-Jun . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3501 | 20.1340 | 1.0000 | Costimulation results in the activation of a signaling pathway that leads to the simultaneous induction of the two proteintranscription factors , AP-1 and NF-kappa B . |
| 0.9726 | 1.0000 | 1.0000 | Costimulation results in the activation of a signaling pathway that leads to the simultaneous induction of the two transcription factors , proteinAP-1 and NF-kappa B . |
| 0.8415 | 0.9996 | 1.0000 | Costimulation results in the activation of a signaling pathway that leads to the simultaneous induction of the two transcription factors , AP-1 and proteinNF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7386 | 20.7821 | 10.9594 | Integration of the signals generated by TCR and CD28 engagement occurs along this pathway, which then bifurcates to induce proteinI kappa B phosphorylation and NF-kappa B activation on the one hand, and JNK activation and c-Jun phosphorylation on the other. |
| 2.2635 | 20.2105 | 1.0000 | Integration of the signals generated by TCR and CD28 engagement occurs along this pathway, which then bifurcates to induce I kappa B phosphorylation and proteinNF-kappa B activation on the one hand, and JNK activation and c-Jun phosphorylation on the other. |
| 1.6259 | 10.3494 | 1.0000 | Integration of the signals generated by proteinTCR and CD28 engagement occurs along this pathway, which then bifurcates to induce I kappa B phosphorylation and NF-kappa B activation on the one hand, and JNK activation and c-Jun phosphorylation on the other. |
| 1.6208 | 10.6468 | 1.0000 | Integration of the signals generated by TCR and CD28 engagement occurs along this pathway, which then bifurcates to induce I kappa B phosphorylation and NF-kappa B activation on the one hand, and JNK activation and proteinc-Jun phosphorylation on the other. |
| 0.8938 | 1.0000 | 1.0000 | Integration of the signals generated by TCR and proteinCD28 engagement occurs along this pathway, which then bifurcates to induce I kappa B phosphorylation and NF-kappa B activation on the one hand, and JNK activation and c-Jun phosphorylation on the other. |
| 0.8803 | 1.0000 | 1.0000 | Integration of the signals generated by TCR and CD28 engagement occurs along this pathway, which then bifurcates to induce I kappa B phosphorylation and NF-kappa B activation on the one hand, and proteinJNK activation and c-Jun phosphorylation on the other. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7322 | 10.1693 | 1.0000 | We are currently engaged in defining where the two signals integrate along the proteinAP-1 / NF-kappa B pathway . |
| 0.8929 | 0.9997 | 0.9997 | We are currently engaged in defining where the two signals integrate along the AP-1 / proteinNF-kappa B pathway . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0356 | 10.8238 | 10.0119 | Regulation of human immunodeficiency virus type 1 and cytokine gene expression in cell_typemyeloid cells by NF-kappa B /Rel transcription factors . |
| 1.3703 | 10.7841 | 0.9344 | Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by proteinNF-kappa B /Rel transcription factors . |
| 4.1354 | 20.5371 | 10.9843 | Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by proteinNF-kappa B /Rel transcription factors . |
| 1.3336 | 10.9700 | 0.9998 | Regulation of human immunodeficiency virus type 1 and DNAcytokine gene expression in myeloid cells by NF-kappa B /Rel transcription factors . |
| Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B /Rel proteintranscription factors . | |||
| Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by proteinNF-kappa B /Rel transcription factors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8975 | 20.8660 | 10.5015 | CD4+ macrophages in tissues such as lung , skin , and lymph nodes , promyelocytic cells in bone marrow , and cell_typeperipheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 ( HIV-1 ) replication . |
| 2.3853 | 20.1178 | 0.9999 | CD4+ macrophages in tissues such as lung , skin , and lymph nodes , cell_typepromyelocytic cells in bone marrow , and peripheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 ( HIV-1 ) replication . |
| 0.9226 | 0.9994 | 1.0000 | cell_typeCD4+ macrophages in tissues such as lung , skin , and lymph nodes , promyelocytic cells in bone marrow , and peripheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 ( HIV-1 ) replication . |
| cell_lineCD4+ macrophages in tissues such as lung , skin , and lymph nodes , promyelocytic cells in bone marrow , and peripheral blood monocytes serve as important targets and reservoirs for human immunodeficiency virus type 1 ( HIV-1 ) replication . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7560 | 0.9986 | 10.5667 | cell_typeHIV-1 -infected myeloid cells are often diminished in their ability to participate in chemotaxis , phagocytosis , and intracellular killing . |
| HIV-1 -infected cell_typemyeloid cells are often diminished in their ability to participate in chemotaxis , phagocytosis , and intracellular killing . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4607 | 20.1822 | 1.0000 | HIV-1 infection of myeloid cells can lead to the expression of proteinsurface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to cytokines secreted by neighboring cells as well as to bacteria or other pathogens. |
| 2.4193 | 20.2436 | 1.0000 | HIV-1 infection of cell_typemyeloid cells can lead to the expression of surface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to cytokines secreted by neighboring cells as well as to bacteria or other pathogens. |
| 1.8070 | 10.5350 | 1.0000 | HIV-1 infection of myeloid cells can lead to the expression of surface receptors associated with cellular activation and/or differentiation that increase the responsiveness of these cells to proteincytokines secreted by neighboring cells as well as to bacteria or other pathogens. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7713 | 20.9816 | 10.9586 | Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of proteincellular transcription factors such as NF-kappa B . |
| 2.1420 | 20.2476 | 0.9999 | Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of cellular transcription factors such as proteinNF-kappa B . |
| 0.6471 | 0.9999 | 0.9999 | Enhancement of HIV-1 replication is related in part to increased DNA-binding activity of cellular proteintranscription factors such as NF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5881 | 20.5692 | 10.7895 | NF-kappa B binds to the HIV-1 enhancer region of the DNAlong terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. |
| 0.9237 | 1.0000 | 1.0000 | proteinNF-kappa B binds to the HIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. |
| 2.9922 | 20.6168 | 10.5126 | NF-kappa B binds to the DNAHIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. |
| 2.1620 | 20.5275 | 1.0000 | NF-kappa B binds to the HIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of DNAHIV-1 gene expression in response to multiple activating agents. |
| NF-kappa B binds to the DNAHIV-1 enhancer region of the long terminal repeat and contributes to the inducibility of HIV-1 gene expression in response to multiple activating agents. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1200 | 20.8008 | 1.0000 | Phosphorylation and degradation of the cytoplasmic inhibitor I kappa B alpha are crucial regulatory events in the activation of proteinNF-kappa B DNA-binding activity . |
| 3.3640 | 20.2071 | 10.5888 | Phosphorylation and degradation of the cytoplasmic inhibitor proteinI kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity . |
| Phosphorylation and degradation of the proteincytoplasmic inhibitor I kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity . | |||
| Phosphorylation and degradation of the cytoplasmic inhibitor proteinI kappa B alpha are crucial regulatory events in the activation of NF-kappa B DNA-binding activity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0143 | 20.8224 | 10.5297 | Both N- and C- terminal residues of proteinI kappa B alpha are required for inducer-mediated degradation . |
| Both N- and C- terminal residues of proteinI kappa B alpha are required for inducer-mediated degradation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6199 | 10.9921 | 1.0000 | Chronic HIV-1 infection of myeloid cells leads to constitutive proteinNF-kappa B DNA-binding activity and provides an intranuclear environment capable of perpetuating HIV-1 replication . |
| 1.5644 | 10.9370 | 0.9999 | Chronic HIV-1 infection of cell_typemyeloid cells leads to constitutive NF-kappa B DNA-binding activity and provides an intranuclear environment capable of perpetuating HIV-1 replication . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6184 | 10.4392 | 1.0000 | Increased intracellular stores of latent proteinNF-kappa B may also result in rapid inducibility of NF-kappa B -dependent cytokine gene expression . |
| 1.5206 | 10.9214 | 1.0000 | Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of proteinNF-kappa B -dependent cytokine gene expression . |
| 1.4813 | 10.9052 | 0.9994 | Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of NF-kappa B -dependent DNAcytokine gene expression . |
| Increased intracellular stores of proteinlatent NF-kappa B may also result in rapid inducibility of NF-kappa B -dependent cytokine gene expression . | |||
| Increased intracellular stores of latent NF-kappa B may also result in rapid inducibility of NF-kappa B -dependent proteincytokine gene expression . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1171 | 20.0213 | 0.9995 | In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1 -infected myeloid cells compared with cell_typeuninfected cells . |
| 1.4885 | 10.6724 | 0.9953 | In response to secondary pathogenic infections or antigenic challenge, proteincytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1 -infected myeloid cells compared with uninfected cells . |
| 4.1062 | 20.7911 | 10.9808 | In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in cell_typeHIV-1 -infected myeloid cells compared with uninfected cells . |
| 1.3530 | 10.6796 | 1.0000 | In response to secondary pathogenic infections or antigenic challenge, DNAcytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1 -infected myeloid cells compared with uninfected cells . |
| In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in HIV-1 -infected cell_typemyeloid cells compared with uninfected cells . | |||
| In response to secondary pathogenic infections or antigenic challenge, cytokine gene expression is rapidly induced, enhanced, and sustained over prolonged periods in cell_lineHIV-1 -infected myeloid cells compared with uninfected cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2097 | 20.4997 | 1.0000 | Elevated levels of several proteininflammatory cytokines have been detected in the sera of HIV-1 -infected individuals . |
| 0.8908 | 1.0000 | 1.0000 | Elevated levels of several inflammatory proteincytokines have been detected in the sera of HIV-1 -infected individuals . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8444 | 20.4381 | 10.8586 | Secretion of proteinmyeloid cell-derived cytokines may both increase virus production and contribute to AIDS-associated disorders . |
| 0.9291 | 1.0000 | 1.0000 | Secretion of myeloid cell-derived proteincytokines may both increase virus production and contribute to AIDS-associated disorders . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.2963 | 10.9022 | 1.0000 | Steroid mediated lysis of cell_typelymphoblasts requires the DNA binding region of the steroid hormone receptor. |
| 3.2532 | 20.3493 | 10.8781 | Steroid mediated lysis of lymphoblasts requires the proteinDNA binding region of the steroid hormone receptor. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6621 | 10.5369 | 1.0000 | Glucocorticoids kill certain types of cell_typelymphoblasts , but the mechanisms are unknown. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7381 | 10.7571 | 1.0000 | It is clear that sufficient numbers of functional proteinglucocorticoid receptors are required to mediate lysis, but whether they do so through the classical model of steroid hormone activation and modulation of gene expression has not been established. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6947 | 20.9355 | 10.6753 | In this report we have asked which region(s) of the steroid receptor are important for mediating lysis in cell_typeleukemic T lymphoblasts . |
| 2.2030 | 20.3099 | 1.0000 | In this report we have asked which region(s) of the proteinsteroid receptor are important for mediating lysis in leukemic T lymphoblasts . |
| In this report we have asked which region(s) of the steroid receptor are important for mediating lysis in leukemic T cell_typelymphoblasts . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2223 | 20.4317 | 0.9999 | CEM-ICR 27 leukemic lymphoblasts , a clone of cell_lineCEM cells which lack functional glucocorticoid receptors and therefore are neither lysed by dexamethasone nor capable of showing glutamine synthetase induction , were provided with steroid receptors by DNA transfections of various receptor gene constructs. |
| 2.1912 | 20.3969 | 1.0000 | CEM-ICR 27 leukemic lymphoblasts , a clone of CEM cells which lack functional glucocorticoid receptors and therefore are neither lysed by dexamethasone nor capable of showing proteinglutamine synthetase induction , were provided with steroid receptors by DNA transfections of various receptor gene constructs. |
| 2.1193 | 20.8840 | 1.0000 | CEM-ICR 27 leukemic lymphoblasts , a clone of CEM cells which lack functional proteinglucocorticoid receptors and therefore are neither lysed by dexamethasone nor capable of showing glutamine synthetase induction , were provided with steroid receptors by DNA transfections of various receptor gene constructs. |
| 2.1144 | 20.7663 | 1.0000 | CEM-ICR 27 leukemic lymphoblasts , a clone of CEM cells which lack functional glucocorticoid receptors and therefore are neither lysed by dexamethasone nor capable of showing glutamine synthetase induction , were provided with proteinsteroid receptors by DNA transfections of various receptor gene constructs. |
| 0.8434 | 0.9863 | 0.9972 | cell_lineCEM-ICR 27 leukemic lymphoblasts , a clone of CEM cells which lack functional glucocorticoid receptors and therefore are neither lysed by dexamethasone nor capable of showing glutamine synthetase induction , were provided with steroid receptors by DNA transfections of various receptor gene constructs. |
| CEM-ICR 27 leukemic cell_typelymphoblasts , a clone of CEM cells which lack functional glucocorticoid receptors and therefore are neither lysed by dexamethasone nor capable of showing glutamine synthetase induction , were provided with steroid receptors by DNA transfections of various receptor gene constructs. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2508 | 20.5616 | 1.0000 | We measured steroid mediated lysis , receptor number and induction of proteinglutamine synthetase in the transfected cells . |
| 1.5668 | 10.6192 | 0.9998 | We measured steroid mediated lysis , receptor number and induction of glutamine synthetase in the cell_linetransfected cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8892 | 20.2163 | 1.0000 | Our results provide evidence that the lysis mechanism in the cell_lineICR27 lymphoblasts is restored when functional receptor number is restored. |
| Our results provide evidence that the lysis mechanism in the ICR27 cell_typelymphoblasts is restored when functional receptor number is restored. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4201 | 10.9104 | 1.0000 | The DNA binding region specifying high affinity for DNAGRE sites is required. |
| 2.5851 | 10.8305 | 10.5301 | The DNADNA binding region specifying high affinity for GRE sites is required. |
| The proteinDNA binding region specifying high affinity for GRE sites is required. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0253 | 20.8261 | 10.6421 | Our data support the view that steroid -mediated cell death occurs by a process requiring direct interaction of proteinsteroid -receptor complexes with the genome. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0614 | 20.5331 | 10.4427 | Functional characterization of the murine homolog of the proteinB cell-specific coactivator BOB.1/OBF.1 . |
| 1.6919 | 20.0274 | 0.9999 | Functional characterization of the proteinmurine homolog of the B cell-specific coactivator BOB.1/OBF.1 . |
| 0.9542 | 0.9999 | 1.0000 | Functional characterization of the murine homolog of the B cell-specific coactivator proteinBOB.1/OBF.1 . |
| 1.8053 | 20.4836 | 20.0708 | Functional characterization of the murine homolog of the proteinB cell-specific coactivator BOB.1/OBF.1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3925 | 20.2665 | 10.6554 | B cell-specific transcriptional promoter activity mediated by the octamer motif requires the Oct1 or Oct2 protein and additional proteinB cell-restricted cofactors . |
| 2.0116 | 20.3846 | 1.0000 | B cell-specific transcriptional promoter activity mediated by the DNAoctamer motif requires the Oct1 or Oct2 protein and additional B cell-restricted cofactors . |
| 1.6333 | 0.9970 | 10.5978 | DNAB cell-specific transcriptional promoter activity mediated by the octamer motif requires the Oct1 or Oct2 protein and additional B cell-restricted cofactors . |
| B cell-specific transcriptional promoter activity mediated by the octamer motif requires the proteinOct1 or Oct2 protein and additional B cell-restricted cofactors . | |||
| B cell-specific transcriptional promoter activity mediated by the octamer motif requires the Oct1 or proteinOct2 protein and additional B cell-restricted cofactors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4187 | 20.4599 | 10.6589 | One such cofactor , BOB.1/OBF.1 , was recently isolated from cell_typehuman B cells . |
| 1.6869 | 10.1399 | 1.0000 | One such cofactor , proteinBOB.1/OBF.1 , was recently isolated from human B cells . |
| 1.5728 | 10.7577 | 1.0000 | One such proteincofactor , BOB.1/OBF.1 , was recently isolated from human B cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1926 | 20.1122 | 1.0000 | Here, we describe the isolation and detailed characterization of the proteinmurine homolog . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6174 | 10.7829 | 1.0000 | Full-length cDNAs and DNAgenomic clones were isolated, and the gene structure was determined. Comparison of the deduced amino acids shows 88% sequence identity between mouse and human BOB.1/OBF.1 . |
| 0.9211 | 1.0000 | 1.0000 | Full-length DNAcDNAs and genomic clones were isolated, and the gene structure was determined. Comparison of the deduced amino acids shows 88% sequence identity between mouse and human BOB.1/OBF.1 . |
| 2.2066 | 20.6496 | 0.9998 | Full-length cDNAs and genomic clones were isolated, and the gene structure was determined. Comparison of the deduced amino acids shows 88% sequence identity between mouse and proteinhuman BOB.1/OBF.1 . |
| 1.4828 | 20.1616 | 1.0000 | Full-length cDNAs and genomic clones were isolated, and the gene structure was determined. Comparison of the deduced proteinamino acids shows 88% sequence identity between mouse and human BOB.1/OBF.1 . |
| 0.7313 | 0.9975 | 0.9998 | DNAFull-length cDNAs and genomic clones were isolated, and the gene structure was determined. Comparison of the deduced amino acids shows 88% sequence identity between mouse and human BOB.1/OBF.1 . |
| 0.5284 | 1.0000 | 0.9999 | Full-length cDNAs and genomic clones were isolated, and the gene structure was determined. Comparison of the deduced amino acids shows 88% sequence identity between mouse and human proteinBOB.1/OBF.1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3035 | 10.6109 | 10.9667 | The proteinNH2-terminal 126 amino acids of BOB.1/OBF.1 are both essential and sufficient for interaction with the POU domains of either Oct1 or Oct2 . |
| 1.4957 | 10.4001 | 1.0000 | The NH2-terminal 126 amino acids of BOB.1/OBF.1 are both essential and sufficient for interaction with the POU domains of either proteinOct1 or Oct2 . |
| 1.3102 | 10.9910 | 0.9999 | The NH2-terminal 126 amino acids of BOB.1/OBF.1 are both essential and sufficient for interaction with the proteinPOU domains of either Oct1 or Oct2 . |
| 0.8833 | 1.0000 | 1.0000 | The NH2-terminal 126 amino acids of proteinBOB.1/OBF.1 are both essential and sufficient for interaction with the POU domains of either Oct1 or Oct2 . |
| 0.8769 | 1.0000 | 1.0000 | The NH2-terminal 126 amino acids of BOB.1/OBF.1 are both essential and sufficient for interaction with the POU domains of either Oct1 or proteinOct2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3859 | 20.3017 | 1.0000 | This protein-protein interaction does not require the simultaneous binding of proteinOct proteins to DNA, and high resolution footprinting of the Oct -DNA interaction reveals that binding of BOB.1/OBF.1 to Oct1 or Oct2 does not alter the interaction with DNA. |
| 1.6158 | 10.3747 | 1.0000 | This protein-protein interaction does not require the simultaneous binding of Oct proteins to DNA, and high resolution footprinting of the Oct -DNA interaction reveals that binding of proteinBOB.1/OBF.1 to Oct1 or Oct2 does not alter the interaction with DNA. |
| 0.9162 | 1.0000 | 1.0000 | This protein-protein interaction does not require the simultaneous binding of Oct proteins to DNA, and high resolution footprinting of the Oct -DNA interaction reveals that binding of BOB.1/OBF.1 to Oct1 or proteinOct2 does not alter the interaction with DNA. |
| 0.8585 | 1.0000 | 1.0000 | This protein-protein interaction does not require the simultaneous binding of Oct proteins to DNA, and high resolution footprinting of the Oct -DNA interaction reveals that binding of BOB.1/OBF.1 to proteinOct1 or Oct2 does not alter the interaction with DNA. |
| 0.9127 | 1.0000 | 1.0000 | This protein-protein interaction does not require the simultaneous binding of Oct proteins to DNA, and high resolution footprinting of the proteinOct -DNA interaction reveals that binding of BOB.1/OBF.1 to Oct1 or Oct2 does not alter the interaction with DNA. |
| This protein-protein interaction does not require the simultaneous binding of Oct proteins to DNA, and high resolution footprinting of the DNAOct -DNA interaction reveals that binding of BOB.1/OBF.1 to Oct1 or Oct2 does not alter the interaction with DNA. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1275 | 20.7531 | 1.0000 | BOB.1/OBF.1 can efficiently activate octamer-dependent promoters in fibroblasts ; however, it fails to stimulate DNAoctamer-dependent enhancer activity . |
| 0.9565 | 1.0000 | 1.0000 | proteinBOB.1/OBF.1 can efficiently activate octamer-dependent promoters in fibroblasts ; however, it fails to stimulate octamer-dependent enhancer activity . |
| 0.8276 | 0.9999 | 1.0000 | BOB.1/OBF.1 can efficiently activate octamer-dependent promoters in cell_typefibroblasts ; however, it fails to stimulate octamer-dependent enhancer activity . |
| 2.1218 | 20.4326 | 1.0000 | BOB.1/OBF.1 can efficiently activate DNAoctamer-dependent promoters in fibroblasts ; however, it fails to stimulate octamer-dependent enhancer activity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7807 | 20.8348 | 10.9440 | Fusion of subdomains of BOB.1/OBF.1 with the proteinGAL4 DNA binding domain reveals that both NH2- and COOH- terminal domains of BOB.1/OBF.1 contribute to full transactivation function, the COOH-terminal domain is more efficient in this transactivation assay . |
| 2.2839 | 20.1899 | 0.9999 | Fusion of subdomains of BOB.1/OBF.1 with the GAL4 DNA binding domain reveals that both NH2- and COOH- terminal domains of BOB.1/OBF.1 contribute to full transactivation function, the proteinCOOH-terminal domain is more efficient in this transactivation assay . |
| 1.7617 | 10.0809 | 1.0000 | Fusion of subdomains of BOB.1/OBF.1 with the GAL4 DNA binding domain reveals that both NH2- and COOH- terminal domains of proteinBOB.1/OBF.1 contribute to full transactivation function, the COOH-terminal domain is more efficient in this transactivation assay . |
| 1.6119 | 10.5865 | 1.0000 | Fusion of subdomains of proteinBOB.1/OBF.1 with the GAL4 DNA binding domain reveals that both NH2- and COOH- terminal domains of BOB.1/OBF.1 contribute to full transactivation function, the COOH-terminal domain is more efficient in this transactivation assay . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7888 | 20.2046 | 10.6719 | Consistent with the failure of full-length BOB.1/OBF.1 to stimulate DNAoctamer-dependent enhancer elements in non B cells , the GAL4 fusions likewise only stimulate from a promoter-proximal position . |
| 2.3915 | 10.9810 | 10.6605 | Consistent with the failure of full-length BOB.1/OBF.1 to stimulate octamer-dependent enhancer elements in cell_typenon B cells , the GAL4 fusions likewise only stimulate from a promoter-proximal position . |
| 1.6401 | 10.2787 | 1.0000 | Consistent with the failure of full-length proteinBOB.1/OBF.1 to stimulate octamer-dependent enhancer elements in non B cells , the GAL4 fusions likewise only stimulate from a promoter-proximal position . |
| 1.4015 | 10.9664 | 1.0000 | Consistent with the failure of full-length BOB.1/OBF.1 to stimulate octamer-dependent enhancer elements in non B cells , the proteinGAL4 fusions likewise only stimulate from a promoter-proximal position . |
| 1.3411 | 10.9316 | 0.9998 | Consistent with the failure of full-length BOB.1/OBF.1 to stimulate octamer-dependent enhancer elements in non B cells , the GAL4 fusions likewise only stimulate from a DNApromoter-proximal position . |
| 0.6194 | 0.9999 | 0.9997 | Consistent with the failure of full-length BOB.1/OBF.1 to stimulate octamer-dependent enhancer elements in non cell_typeB cells , the GAL4 fusions likewise only stimulate from a promoter-proximal position . |
| Consistent with the failure of proteinfull-length BOB.1/OBF.1 to stimulate octamer-dependent enhancer elements in non B cells , the GAL4 fusions likewise only stimulate from a promoter-proximal position . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6608 | 10.6713 | 20.2647 | Anti-immunoglobulin M activates proteinnuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes . |
| 2.5637 | 20.8514 | 10.8305 | Anti-immunoglobulin M activates nuclear calcium/calmodulin-dependent protein kinase II in cell_typehuman B lymphocytes . |
| 0.7461 | 0.9981 | 0.9993 | proteinAnti-immunoglobulin M activates nuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8786 | 20.8391 | 10.2988 | We and others have previously shown that the nuclear protein , Ets-1 , is phosphorylated in a calcium-dependent manner after ligation of proteinimmunoglobulin (Ig) M on B lymphocytes . |
| 2.2858 | 20.1737 | 1.0000 | We and others have previously shown that the proteinnuclear protein , Ets-1 , is phosphorylated in a calcium-dependent manner after ligation of immunoglobulin (Ig) M on B lymphocytes . |
| 1.5196 | 10.5954 | 0.9995 | We and others have previously shown that the nuclear protein , Ets-1 , is phosphorylated in a calcium-dependent manner after ligation of immunoglobulin (Ig) M on cell_typeB lymphocytes . |
| 0.9411 | 1.0000 | 1.0000 | We and others have previously shown that the nuclear protein , proteinEts-1 , is phosphorylated in a calcium-dependent manner after ligation of immunoglobulin (Ig) M on B lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7268 | 20.9744 | 10.9026 | As this phosphorylation was independent of protein kinase C activity , we tested whether a proteincalcium/calmodulin-dependent protein kinase ( CaM kinase ) might phosphorylate the Ets-1 protein after elevation of intracellular free calcium concentrations . |
| 3.5558 | 20.9711 | 10.9876 | As this phosphorylation was independent of proteinprotein kinase C activity , we tested whether a calcium/calmodulin-dependent protein kinase ( CaM kinase ) might phosphorylate the Ets-1 protein after elevation of intracellular free calcium concentrations . |
| 2.0505 | 20.8416 | 1.0000 | As this phosphorylation was independent of protein kinase C activity , we tested whether a calcium/calmodulin-dependent protein kinase ( CaM kinase ) might phosphorylate the proteinEts-1 protein after elevation of intracellular free calcium concentrations . |
| 1.8887 | 20.9119 | 0.9892 | As this phosphorylation was independent of protein kinase C activity , we tested whether a calcium/calmodulin-dependent protein kinase ( CaM kinase ) might phosphorylate the proteinEts-1 protein after elevation of intracellular free calcium concentrations . |
| 1.6640 | 10.0202 | 1.0000 | As this phosphorylation was independent of protein kinase C activity , we tested whether a calcium/calmodulin-dependent protein kinase ( proteinCaM kinase ) might phosphorylate the Ets-1 protein after elevation of intracellular free calcium concentrations . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7715 | 10.9453 | 1.0000 | The dephosphorylated form of Ets-1 has been shown to bind to DNAchromatin , suggesting that the operative kinase should be detectable in the nucleus . |
| 1.6830 | 10.6451 | 1.0000 | The dephosphorylated form of proteinEts-1 has been shown to bind to chromatin , suggesting that the operative kinase should be detectable in the nucleus . |
| The dephosphorylated form of Ets-1 has been shown to bind to chromatin , suggesting that the proteinoperative kinase should be detectable in the nucleus . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0684 | 20.9953 | 10.8758 | We prepared nuclear extracts from two cell_linehuman B cell lines in which increased intracellular free calcium levels correlated with increased phosphorylation of the Ets-1 protein. |
| 1.9889 | 20.6805 | 0.9996 | We prepared nuclear extracts from two human B cell lines in which increased intracellular free calcium levels correlated with increased phosphorylation of the proteinEts-1 protein. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8510 | 20.9928 | 10.4250 | Activity of the CaM kinases was determined using a synthetic peptide substrate both in the absence and presence of an inhibitor specific for the proteinCaM kinase family , KN-62 . |
| 2.2270 | 20.6331 | 1.0000 | Activity of the proteinCaM kinases was determined using a synthetic peptide substrate both in the absence and presence of an inhibitor specific for the CaM kinase family , KN-62 . |
| 2.1792 | 20.9616 | 10.5753 | Activity of the CaM kinases was determined using a proteinsynthetic peptide substrate both in the absence and presence of an inhibitor specific for the CaM kinase family , KN-62 . |
| 0.8316 | 0.9999 | 1.0000 | Activity of the CaM kinases was determined using a synthetic peptide substrate both in the absence and presence of an inhibitor specific for the CaM kinase family , proteinKN-62 . |
| Activity of the CaM kinases was determined using a synthetic peptide substrate both in the absence and presence of an inhibitor specific for the proteinCaM kinase family , KN-62 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4160 | 20.1691 | 1.0000 | Stimulation of cells with anti-IgM led to increased activity of a proteinnuclear kinase that could phosphorylate the peptide, and this activity was reduced by 10 microM KN-62 . |
| 1.7580 | 10.7099 | 1.0000 | Stimulation of cells with proteinanti-IgM led to increased activity of a nuclear kinase that could phosphorylate the peptide, and this activity was reduced by 10 microM KN-62 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9084 | 20.7231 | 10.6262 | Kinase activity was reduced in lysates preadsorbed using an antibody specific for proteinCaM kinase II . |
| Kinase activity was reduced in lysates preadsorbed using an proteinantibody specific for CaM kinase II . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6960 | 10.3552 | 1.0000 | Two-dimensional phosphopeptide maps of the Ets-1 protein from cells incubated with ionomycin or proteinanti-IgM contained two unique phosphopeptides that were absent in untreated cells. |
| 1.4612 | 10.7877 | 1.0000 | Two-dimensional phosphopeptide maps of the proteinEts-1 protein from cells incubated with ionomycin or anti-IgM contained two unique phosphopeptides that were absent in untreated cells. |
| 0.9168 | 1.0000 | 1.0000 | Two-dimensional phosphopeptide maps of the Ets-1 protein from cells incubated with ionomycin or anti-IgM contained two unique proteinphosphopeptides that were absent in untreated cells. |
| Two-dimensional phosphopeptide maps of the proteinEts-1 protein from cells incubated with ionomycin or anti-IgM contained two unique phosphopeptides that were absent in untreated cells. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4565 | 20.4599 | 10.7863 | Incubation of isolated Ets-1 protein with purified proteinCaM kinase II produced phosphorylation of peptides that migrated identically to those found in cells incubated with either anti-IgM or ionomycin . |
| 1.5603 | 10.6995 | 1.0000 | Incubation of isolated Ets-1 protein with purified CaM kinase II produced phosphorylation of peptides that migrated identically to those found in cells incubated with either proteinanti-IgM or ionomycin . |
| 1.9877 | 20.9442 | 0.9999 | Incubation of isolated proteinEts-1 protein with purified CaM kinase II produced phosphorylation of peptides that migrated identically to those found in cells incubated with either anti-IgM or ionomycin . |
| Incubation of proteinisolated Ets-1 protein with purified CaM kinase II produced phosphorylation of peptides that migrated identically to those found in cells incubated with either anti-IgM or ionomycin . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.5454 | 30.1832 | 10.5425 | These data suggest a model of signal transduction by the antigen receptor on B lymphocytes in which increased intracellular free calcium can rapidly activate proteinnuclear CaM kinase II , potentially resulting in phosphorylation and regulation of DNA-binding proteins . |
| 2.1644 | 20.6043 | 0.9999 | These data suggest a model of signal transduction by the proteinantigen receptor on B lymphocytes in which increased intracellular free calcium can rapidly activate nuclear CaM kinase II , potentially resulting in phosphorylation and regulation of DNA-binding proteins . |
| 2.1639 | 20.4714 | 0.9999 | These data suggest a model of signal transduction by the antigen receptor on B lymphocytes in which increased intracellular free calcium can rapidly activate nuclear CaM kinase II , potentially resulting in phosphorylation and regulation of proteinDNA-binding proteins . |
| 1.5184 | 10.8849 | 0.9998 | These data suggest a model of signal transduction by the antigen receptor on cell_typeB lymphocytes in which increased intracellular free calcium can rapidly activate nuclear CaM kinase II , potentially resulting in phosphorylation and regulation of DNA-binding proteins . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4206 | 20.7943 | 10.8612 | Transcriptional activation and repression , two properties of the proteinlymphoid-specific transcription factor Oct-2a . |
| 0.9833 | 1.0000 | 1.0000 | Transcriptional activation and repression , two properties of the lymphoid-specific transcription factor proteinOct-2a . |
| 0.6191 | 0.9999 | 0.9950 | Transcriptional activation and repression , two properties of the lymphoid-specific proteintranscription factor Oct-2a . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2897 | 20.8252 | 10.7515 | The lymphoid-specific transcription factor Oct-2a contains two proteintranscriptional activation domains which are located within the N-terminal and C-terminal regions . |
| 2.8167 | 10.5730 | 10.5264 | The proteinlymphoid-specific transcription factor Oct-2a contains two transcriptional activation domains which are located within the N-terminal and C-terminal regions . |
| 0.9858 | 1.0000 | 1.0000 | The lymphoid-specific transcription factor proteinOct-2a contains two transcriptional activation domains which are located within the N-terminal and C-terminal regions . |
| The lymphoid-specific transcription factor Oct-2a contains two transcriptional activation domains which are located within the proteinN-terminal and C-terminal regions . | |||
| The lymphoid-specific transcription factor Oct-2a contains two transcriptional activation domains which are located within the N-terminal and proteinC-terminal regions . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8001 | 20.2904 | 10.8497 | To study their differential activation properties , we linked the isolated effector domains to the proteinGAL4 DNA-binding domain . |
| 2.0304 | 20.1604 | 0.9999 | To study their differential activation properties , we linked the isolated proteineffector domains to the GAL4 DNA-binding domain . |
| To study their proteindifferential activation properties , we linked the isolated effector domains to the GAL4 DNA-binding domain . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3160 | 20.1513 | 1.0000 | We have shown that both activating regions of Oct-2a , isolated from their natural context, can activate transcription as proteinpromoter factors . |
| 1.7376 | 10.2437 | 1.0000 | We have shown that both activating regions of proteinOct-2a , isolated from their natural context, can activate transcription as promoter factors . |
| 2.2976 | 20.0770 | 1.0000 | We have shown that both proteinactivating regions of Oct-2a , isolated from their natural context, can activate transcription as promoter factors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8826 | 20.8306 | 10.4568 | In contrast to the C-terminus , activation by the N-terminal domain is dependent on a yet unidentified factor(s) binding to the DNAsimian virus 40 enhancer . |
| 2.0948 | 20.2882 | 1.0000 | In contrast to the C-terminus , activation by the proteinN-terminal domain is dependent on a yet unidentified factor(s) binding to the simian virus 40 enhancer . |
| 1.4555 | 10.5934 | 1.0000 | In contrast to the proteinC-terminus , activation by the N-terminal domain is dependent on a yet unidentified factor(s) binding to the simian virus 40 enhancer . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4635 | 20.1464 | 1.0000 | The results obtained by duplication of proteinactivation domains or their mixed combination suggest that the domains are functionally independent. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6743 | 10.2644 | 0.9998 | However, activation from a remote position could only be achieved with the C-terminus of Oct-2a in cell_typeB cells . |
| 1.5726 | 10.6212 | 1.0000 | However, activation from a remote position could only be achieved with the proteinC-terminus of Oct-2a in B cells . |
| 0.8378 | 0.9999 | 1.0000 | However, activation from a remote position could only be achieved with the C-terminus of proteinOct-2a in B cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2549 | 20.5740 | 1.0000 | In lymphoid cells , higher activation levels were observed, suggesting that distinct proteinB-cell-specific cofactors in concert with the effector domains of Oct-2a might be involved in mediating transcription from proximal and remote positions . |
| 2.2524 | 20.6411 | 1.0000 | In lymphoid cells , higher activation levels were observed, suggesting that distinct B-cell-specific cofactors in concert with the proteineffector domains of Oct-2a might be involved in mediating transcription from proximal and remote positions . |
| 1.7604 | 10.2983 | 1.0000 | In lymphoid cells , higher activation levels were observed, suggesting that distinct B-cell-specific cofactors in concert with the effector domains of proteinOct-2a might be involved in mediating transcription from proximal and remote positions . |
| 1.6225 | 10.1449 | 0.9999 | In cell_typelymphoid cells , higher activation levels were observed, suggesting that distinct B-cell-specific cofactors in concert with the effector domains of Oct-2a might be involved in mediating transcription from proximal and remote positions . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8085 | 0.9999 | 1.0000 | Furthermore, we identified a repression domain at the N-terminus of proteinOct-2a . |
| 2.0013 | 20.4431 | 0.9999 | Furthermore, we identified a proteinrepression domain at the N-terminus of Oct-2a . |
| 1.1503 | 10.9774 | 0.9999 | Furthermore, we identified a repression domain at the proteinN-terminus of Oct-2a . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3276 | 20.3442 | 1.0000 | When transferred to a proteinpotent activator , transcriptional stimulation was inhibited efficiently. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7318 | 10.6821 | 1.0000 | These results underscore the modular structure of proteinOct-2a with separable domains for activation and repression and suggest that Oct-2a might have complex regulatory functions in vivo. |
| 1.7166 | 10.5576 | 1.0000 | These results underscore the modular structure of Oct-2a with separable domains for activation and repression and suggest that proteinOct-2a might have complex regulatory functions in vivo. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7292 | 10.3694 | 1.0000 | Nonopsonic phagocytosis of Pseudomonas aeruginosa by cell_typemacrophages and polymorphonuclear leukocytes requires the presence of the bacterial flagellum . |
| 1.5671 | 10.3535 | 0.9999 | Nonopsonic phagocytosis of Pseudomonas aeruginosa by macrophages and cell_typepolymorphonuclear leukocytes requires the presence of the bacterial flagellum . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6011 | 20.7191 | 10.3767 | To identify the requisite bacterial ligands , studies with isogenic mutants of P. aeruginosa PAK lacking pili , flagella , and the proteinRpoN sigma factor were undertaken. |
| 3.5010 | 20.4506 | 10.7673 | To identify the requisite bacterial ligands , studies with isogenic mutants of proteinP. aeruginosa PAK lacking pili , flagella , and the RpoN sigma factor were undertaken. |
| 1.5216 | 20.0733 | 0.9949 | To identify the requisite bacterial ligands , studies with isogenic mutants of P. aeruginosa PAK lacking pili , flagella , and the proteinRpoN sigma factor were undertaken. |
| 0.9615 | 1.0000 | 1.0000 | To identify the requisite bacterial ligands , studies with isogenic mutants of P. aeruginosa PAK lacking pili , proteinflagella , and the RpoN sigma factor were undertaken. |
| 0.9550 | 1.0000 | 1.0000 | To identify the requisite bacterial ligands , studies with isogenic mutants of P. aeruginosa PAK lacking proteinpili , flagella , and the RpoN sigma factor were undertaken. |
| 0.7312 | 1.0000 | 1.0000 | To identify the requisite bacterial ligands , studies with isogenic mutants of P. aeruginosa proteinPAK lacking pili , flagella , and the RpoN sigma factor were undertaken. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5200 | 10.5764 | 0.9999 | The RpoN mutant , lacking pili , flagella , and nonpilus adhesins , bound poorly and was resistant to ingestion by both cell_typemacrophages and neutrophils . |
| 1.4791 | 10.6749 | 0.9999 | The RpoN mutant , lacking pili , flagella , and proteinnonpilus adhesins , bound poorly and was resistant to ingestion by both macrophages and neutrophils . |
| 0.8422 | 0.9999 | 0.9999 | The RpoN mutant , lacking pili , flagella , and nonpilus adhesins , bound poorly and was resistant to ingestion by both macrophages and cell_typeneutrophils . |
| 1.6827 | 10.9191 | 1.0000 | The RpoN mutant , lacking proteinpili , flagella , and nonpilus adhesins , bound poorly and was resistant to ingestion by both macrophages and neutrophils . |
| 1.5543 | 10.5255 | 0.9866 | The proteinRpoN mutant , lacking pili , flagella , and nonpilus adhesins , bound poorly and was resistant to ingestion by both macrophages and neutrophils . |
| 1.4217 | 10.7077 | 1.0000 | The proteinRpoN mutant , lacking pili , flagella , and nonpilus adhesins , bound poorly and was resistant to ingestion by both macrophages and neutrophils . |
| 0.9395 | 1.0000 | 1.0000 | The RpoN mutant , lacking pili , proteinflagella , and nonpilus adhesins , bound poorly and was resistant to ingestion by both macrophages and neutrophils . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9861 | 1.0000 | 1.0000 | proteinPili were not absolutely required for binding or phagocytosis of P. aeruginosa . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9047 | 10.1228 | 1.0000 | The presence of a flagellum was not required for binding of P. aeruginosa to cell_typemacrophages but was critical for the subsequent internalization of the bacterium , suggesting that this factor or a surface ligand associated with its assembly was responsible for stimulation of nonopsonic phagocytosis . |
| 2.5270 | 20.3615 | 1.0000 | The presence of a flagellum was not required for binding of P. aeruginosa to macrophages but was critical for the subsequent internalization of the bacterium , suggesting that this factor or a proteinsurface ligand associated with its assembly was responsible for stimulation of nonopsonic phagocytosis . |
| 0.9294 | 1.0000 | 1.0000 | The presence of a proteinflagellum was not required for binding of P. aeruginosa to macrophages but was critical for the subsequent internalization of the bacterium , suggesting that this factor or a surface ligand associated with its assembly was responsible for stimulation of nonopsonic phagocytosis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.9402 | 20.9445 | 10.5430 | Identification of essential GATA and Ets binding motifs within the promoter of the DNAplatelet glycoprotein Ib alpha gene . |
| 1.6220 | 20.7177 | 10.5157 | Identification of essential GATA and Ets binding motifs within the promoter of the proteinplatelet glycoprotein Ib alpha gene . |
| 0.8494 | 1.0000 | 1.0000 | Identification of essential GATA and Ets binding motifs within the DNApromoter of the platelet glycoprotein Ib alpha gene . |
| Identification of essential GATA and DNAEts binding motifs within the promoter of the platelet glycoprotein Ib alpha gene . | |||
| Identification of essential DNAGATA and Ets binding motifs within the promoter of the platelet glycoprotein Ib alpha gene . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1592 | 30.4002 | 10.4774 | Platelet glycoprotein ( GP ) Ib-IX-V is a proteinmultisubunit adhesion receptor that supports platelet attachment to thrombogenic surfaces at sites of vascular injury . |
| 1.7152 | 0.9983 | 20.9867 | proteinPlatelet glycoprotein ( GP ) Ib-IX-V is a multisubunit adhesion receptor that supports platelet attachment to thrombogenic surfaces at sites of vascular injury . |
| proteinPlatelet glycoprotein ( GP ) Ib-IX-V is a multisubunit adhesion receptor that supports platelet attachment to thrombogenic surfaces at sites of vascular injury . | |||
| Platelet glycoprotein ( GP ) proteinIb-IX-V is a multisubunit adhesion receptor that supports platelet attachment to thrombogenic surfaces at sites of vascular injury . | |||
| Platelet glycoprotein ( proteinGP ) Ib-IX-V is a multisubunit adhesion receptor that supports platelet attachment to thrombogenic surfaces at sites of vascular injury . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3593 | 20.4433 | 1.0000 | The congenital absence of the receptor results in a bleeding disorder associated with cell_type"giant" platelets , a condition linking the expression of the complex to platelet morphogenesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8921 | 20.5679 | 10.3703 | To understand better the expression of the GP Ib-IX-V complex , studies were undertaken to define the essential genetic elements supporting the expression of the alpha-subunit of the complex ( proteinGP Ib alpha ). |
| 3.8846 | 20.9111 | 10.6199 | To understand better the expression of the proteinGP Ib-IX-V complex , studies were undertaken to define the essential genetic elements supporting the expression of the alpha-subunit of the complex ( GP Ib alpha ). |
| 1.5628 | 10.1821 | 1.0000 | To understand better the expression of the GP Ib-IX-V complex , studies were undertaken to define the essential genetic elements supporting the expression of the proteinalpha-subunit of the complex ( GP Ib alpha ). |
| 0.7211 | 0.9999 | 1.0000 | To understand better the expression of the GP Ib-IX-V complex , studies were undertaken to define the essential genetic elements supporting the expression of the alpha-subunit of the proteincomplex ( GP Ib alpha ). |
| To understand better the expression of the GP proteinIb-IX-V complex , studies were undertaken to define the essential genetic elements supporting the expression of the alpha-subunit of the complex ( GP Ib alpha ). | |||
| To understand better the expression of the proteinGP Ib-IX-V complex , studies were undertaken to define the essential genetic elements supporting the expression of the alpha-subunit of the complex ( GP Ib alpha ). | |||
| To understand better the expression of the GP Ib-IX-V complex , studies were undertaken to define the essential DNAgenetic elements supporting the expression of the alpha-subunit of the complex ( GP Ib alpha ). | |||
| To understand better the expression of the GP Ib-IX-V complex , studies were undertaken to define the essential genetic elements supporting the expression of the alpha-subunit of the complex ( proteinGP Ib alpha ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8788 | 1.0000 | 1.0000 | GP Ib alpha promoter activity was evaluated by transfection of human erythroleukemia cells with reporter plasmids coding for the enzyme , proteinluciferase . |
| 3.7895 | 20.5507 | 10.6806 | GP Ib alpha promoter activity was evaluated by transfection of cell_linehuman erythroleukemia cells with reporter plasmids coding for the enzyme , luciferase . |
| 1.5813 | 0.9995 | 10.8829 | proteinGP Ib alpha promoter activity was evaluated by transfection of human erythroleukemia cells with reporter plasmids coding for the enzyme , luciferase . |
| 1.4441 | 10.4605 | 0.9999 | GP Ib alpha promoter activity was evaluated by transfection of human erythroleukemia cells with DNAreporter plasmids coding for the enzyme , luciferase . |
| 0.7766 | 0.9996 | 0.9999 | GP Ib alpha DNApromoter activity was evaluated by transfection of human erythroleukemia cells with reporter plasmids coding for the enzyme , luciferase . |
| proteinGP Ib alpha promoter activity was evaluated by transfection of human erythroleukemia cells with reporter plasmids coding for the enzyme , luciferase . | |||
| GP Ib alpha promoter activity was evaluated by transfection of human erythroleukemia cells with reporter plasmids coding for the proteinenzyme , luciferase . | |||
| GP Ib alpha promoter activity was evaluated by transfection of cell_typehuman erythroleukemia cells with reporter plasmids coding for the enzyme , luciferase . | |||
| DNAGP Ib alpha promoter activity was evaluated by transfection of human erythroleukemia cells with reporter plasmids coding for the enzyme , luciferase . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6193 | 20.3441 | 10.6941 | Studies were initiated with a fragment extending 2,738 nucleotides 5' to the DNAtranscription start site and lead to the identification of 253 nucleotides retaining full promoter activity in human erythroleukemia cells . |
| 3.4799 | 20.3202 | 10.7167 | Studies were initiated with a fragment extending 2,738 nucleotides 5' to the transcription start site and lead to the identification of 253 nucleotides retaining full promoter activity in cell_typehuman erythroleukemia cells . |
| 2.1261 | 20.8576 | 1.0000 | Studies were initiated with a fragment extending 2,738 nucleotides 5' to the transcription start site and lead to the identification of DNA253 nucleotides retaining full promoter activity in human erythroleukemia cells . |
| 1.7647 | 20.7815 | 0.9871 | Studies were initiated with a fragment extending DNA2,738 nucleotides 5' to the transcription start site and lead to the identification of 253 nucleotides retaining full promoter activity in human erythroleukemia cells . |
| 1.3780 | 20.6004 | 0.9999 | Studies were initiated with a fragment extending DNA2,738 nucleotides 5' to the transcription start site and lead to the identification of 253 nucleotides retaining full promoter activity in human erythroleukemia cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3652 | 20.8754 | 10.9338 | In cells of nonhematopoietic lineage , human endothelial and HeLa cells , the proteinGP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs . |
| 2.1716 | 20.6791 | 0.9999 | In cells of nonhematopoietic lineage , human endothelial and HeLa cells , the GP Ib alpha promoter activity was no greater than background levels obtained with DNApromoterless constructs . |
| 1.2408 | 10.9233 | 0.9998 | In cells of cell_typenonhematopoietic lineage , human endothelial and HeLa cells , the GP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs . |
| 1.1679 | 10.4532 | 0.9998 | In cells of nonhematopoietic lineage , cell_typehuman endothelial and HeLa cells , the GP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs . |
| 1.5062 | 10.9910 | 0.9999 | In cells of nonhematopoietic lineage , human endothelial and cell_lineHeLa cells , the GP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs . |
| In cells of nonhematopoietic lineage , human endothelial and HeLa cells , the proteinGP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs . | |||
| In cells of nonhematopoietic lineage , human endothelial and HeLa cells , the DNAGP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs . | |||
| In cells of nonhematopoietic lineage , human endothelial and cell_typeHeLa cells , the GP Ib alpha promoter activity was no greater than background levels obtained with promoterless constructs . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0003 | 20.8275 | 10.8839 | Gel shift assays and site-directed mutagenesis studies defined essential GATA and Ets binding motifs 93 and 150 nucleotides upstream of the DNAtranscription start site , a finding which further substantiates these elements as important determinants of megakaryocytic gene expression . |
| 1.3755 | 10.5770 | 0.9999 | Gel shift assays and site-directed mutagenesis studies defined essential GATA and Ets binding motifs 93 and 150 nucleotides upstream of the transcription start site , a finding which further substantiates these elements as important determinants of DNAmegakaryocytic gene expression . |
| Gel shift assays and site-directed mutagenesis studies defined essential DNAGATA and Ets binding motifs 93 and 150 nucleotides upstream of the transcription start site , a finding which further substantiates these elements as important determinants of megakaryocytic gene expression . | |||
| Gel shift assays and site-directed mutagenesis studies defined essential GATA and DNAEts binding motifs 93 and 150 nucleotides upstream of the transcription start site , a finding which further substantiates these elements as important determinants of megakaryocytic gene expression . | |||
| Gel shift assays and site-directed mutagenesis studies defined essential GATA and Ets binding motifs DNA93 and 150 nucleotides upstream of the transcription start site , a finding which further substantiates these elements as important determinants of megakaryocytic gene expression . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8383 | 20.7992 | 10.5505 | The results define essential cis-acting elements responsible for the expression of proteinGP Ib alpha and provide insights into molecular events coinciding with the release of normal platelets into the bloodstream . |
| 2.2835 | 20.8047 | 0.9999 | The results define essential cis-acting elements responsible for the expression of GP Ib alpha and provide insights into molecular events coinciding with the release of cell_typenormal platelets into the bloodstream . |
| 2.1532 | 20.6070 | 0.9999 | The results define essential DNAcis-acting elements responsible for the expression of GP Ib alpha and provide insights into molecular events coinciding with the release of normal platelets into the bloodstream . |
| The results define essential cis-acting elements responsible for the expression of proteinGP Ib alpha and provide insights into molecular events coinciding with the release of normal platelets into the bloodstream . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6039 | 20.1251 | 10.7102 | CD30 ligation induces nuclear factor-kappa B activation in cell_linehuman T cell lines . |
| 3.0375 | 20.5739 | 10.5746 | CD30 ligation induces proteinnuclear factor-kappa B activation in human T cell lines . |
| 0.9633 | 1.0000 | 1.0000 | proteinCD30 ligation induces nuclear factor-kappa B activation in human T cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.2371 | 30.5382 | 20.2304 | CD30 is a recently described member of the proteintumor necrosis factor /nerve growth factor receptor superfamily . |
| 0.9541 | 1.0000 | 1.0000 | proteinCD30 is a recently described member of the tumor necrosis factor /nerve growth factor receptor superfamily . |
| CD30 is a recently described member of the tumor necrosis factor protein/nerve growth factor receptor superfamily . | |||
| CD30 is a recently described member of the proteintumor necrosis factor /nerve growth factor receptor superfamily . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7043 | 20.8546 | 20.6151 | In this report, we show that following incubation of L540 cells ( cell_lineHodgkin's disease -derived, T cell-like, CD30 + cells ) with the agonistic anti- CD30 monoclonal antibodies ( mAb ) M44 and M67 , two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts , as determined in gel retardation assays . |
| 4.6599 | 20.6734 | 10.9177 | In this report, we show that following incubation of L540 cells ( Hodgkin's disease -derived, T cell-like, CD30 + cells ) with the agonistic anti- CD30 monoclonal antibodies ( mAb ) M44 and M67 , two proteinnuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts , as determined in gel retardation assays . |
| 1.4059 | 10.9800 | 0.9992 | In this report, we show that following incubation of cell_lineL540 cells ( Hodgkin's disease -derived, T cell-like, CD30 + cells ) with the agonistic anti- CD30 monoclonal antibodies ( mAb ) M44 and M67 , two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts , as determined in gel retardation assays . |
| 0.9715 | 1.0000 | 0.9837 | In this report, we show that following incubation of L540 cells ( Hodgkin's disease -derived, T cell-like, proteinCD30 + cells ) with the agonistic anti- CD30 monoclonal antibodies ( mAb ) M44 and M67 , two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts , as determined in gel retardation assays . |
| 0.9644 | 1.0000 | 1.0000 | In this report, we show that following incubation of L540 cells ( Hodgkin's disease -derived, T cell-like, CD30 + cells ) with the agonistic anti- CD30 monoclonal antibodies ( proteinmAb ) M44 and M67 , two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts , as determined in gel retardation assays . |
| 0.9633 | 1.0000 | 1.0000 | In this report, we show that following incubation of L540 cells ( Hodgkin's disease -derived, T cell-like, CD30 + cells ) with the agonistic anti- CD30 monoclonal antibodies ( mAb ) proteinM44 and M67 , two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts , as determined in gel retardation assays . |
| 0.9632 | 1.0000 | 1.0000 | In this report, we show that following incubation of L540 cells ( Hodgkin's disease -derived, T cell-like, CD30 + cells ) with the agonistic anti- CD30 monoclonal antibodies ( mAb ) M44 and proteinM67 , two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts , as determined in gel retardation assays . |
| 0.9348 | 1.0000 | 0.9964 | In this report, we show that following incubation of L540 cells ( Hodgkin's disease -derived, T cell-like, CD30 + cells ) with the agonistic anti- proteinCD30 monoclonal antibodies ( mAb ) M44 and M67 , two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts , as determined in gel retardation assays . |
| 4.5850 | 20.4387 | 10.9107 | In this report, we show that following incubation of L540 cells ( Hodgkin's disease -derived, T cell-like, CD30 + cells ) with the agonistic proteinanti- CD30 monoclonal antibodies ( mAb ) M44 and M67 , two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts , as determined in gel retardation assays . |
| In this report, we show that following incubation of L540 cells ( Hodgkin's disease -derived, T cell-like, CD30 + cells ) with the proteinagonistic anti- CD30 monoclonal antibodies ( mAb ) M44 and M67 , two nuclear factor (NF)-kappa B DNA binding activities were induced in nuclear extracts , as determined in gel retardation assays . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7331 | 10.0295 | 1.0000 | The effect of the mAb towards proteinNF-kappa B activation was rapid, as it occurred within 20 min, and was sustained for up to 6 h. |
| 0.8795 | 0.9999 | 1.0000 | The effect of the proteinmAb towards NF-kappa B activation was rapid, as it occurred within 20 min, and was sustained for up to 6 h. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1572 | 20.1493 | 1.0000 | By comparison, an proteinisotype-matched antibody had no effect on NF-kappa B activation . |
| 1.4696 | 10.9381 | 1.0000 | By comparison, an isotype-matched antibody had no effect on proteinNF-kappa B activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.9328 | 20.9304 | 20.4660 | Moreover, in cell_linehuman T helper (Th) clones functionally characterized as being of the type 0, type 1 and type 2 (28%, < 1% und 93% CD30+, respectively), the extent of CD30 -mediated NF-kappa B activation correlated with the proportion of CD30+ cells . |
| 1.5769 | 10.0904 | 1.0000 | Moreover, in human T helper (Th) clones functionally characterized as being of the type 0, type 1 and type 2 (28%, < 1% und 93% CD30+, respectively), the extent of proteinCD30 -mediated NF-kappa B activation correlated with the proportion of CD30+ cells . |
| 1.5353 | 10.2926 | 1.0000 | Moreover, in human T helper (Th) clones functionally characterized as being of the type 0, type 1 and type 2 (28%, < 1% und 93% CD30+, respectively), the extent of CD30 -mediated proteinNF-kappa B activation correlated with the proportion of CD30+ cells . |
| Moreover, in human T helper (Th) clones functionally characterized as being of the type 0, type 1 and type 2 (28%, < 1% und 93% CD30+, respectively), the extent of CD30 -mediated NF-kappa B activation correlated with the proportion of cell_lineCD30+ cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2834 | 20.2521 | 0.9999 | In all cell lines investigated, the proteinNF-kappa B complexes induced following CD30 engagement were shown to contain p50 NF-kappa B1 , p65 RelA , and possibly other transcription factors . |
| 2.0812 | 20.6063 | 0.9999 | In all cell lines investigated, the NF-kappa B complexes induced following CD30 engagement were shown to contain p50 NF-kappa B1 , p65 RelA , and possibly other proteintranscription factors . |
| 1.8132 | 10.0469 | 1.0000 | In all cell lines investigated, the NF-kappa B complexes induced following CD30 engagement were shown to contain p50 NF-kappa B1 , proteinp65 RelA , and possibly other transcription factors . |
| 1.7625 | 20.6328 | 0.7076 | In all cell lines investigated, the proteinNF-kappa B complexes induced following CD30 engagement were shown to contain p50 NF-kappa B1 , p65 RelA , and possibly other transcription factors . |
| 0.8310 | 1.0000 | 1.0000 | In all cell lines investigated, the NF-kappa B complexes induced following proteinCD30 engagement were shown to contain p50 NF-kappa B1 , p65 RelA , and possibly other transcription factors . |
| 1.9679 | 20.0272 | 0.9998 | In all cell_linecell lines investigated, the NF-kappa B complexes induced following CD30 engagement were shown to contain p50 NF-kappa B1 , p65 RelA , and possibly other transcription factors . |
| 1.4654 | 10.0789 | 1.0000 | In all cell lines investigated, the NF-kappa B complexes induced following CD30 engagement were shown to contain proteinp50 NF-kappa B1 , p65 RelA , and possibly other transcription factors . |
| 0.8886 | 0.9985 | 1.0000 | In all cell lines investigated, the NF-kappa B complexes induced following CD30 engagement were shown to contain p50 proteinNF-kappa B1 , p65 RelA , and possibly other transcription factors . |
| 0.7996 | 1.0000 | 0.9980 | In all cell lines investigated, the NF-kappa B complexes induced following CD30 engagement were shown to contain p50 NF-kappa B1 , proteinp65 RelA , and possibly other transcription factors . |
| 0.6464 | 1.0000 | 1.0000 | In all cell lines investigated, the NF-kappa B complexes induced following CD30 engagement were shown to contain p50 NF-kappa B1 , p65 proteinRelA , and possibly other transcription factors . |
| In all cell lines investigated, the NF-kappa B complexes induced following CD30 engagement were shown to contain proteinp50 NF-kappa B1 , p65 RelA , and possibly other transcription factors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4596 | 20.1738 | 1.0000 | Collectively, our results demonstrate that nuclear translocation and activation of proteinNF-kappa B rank among the short-term cellular responses elicited following CD30 ligation . |
| 1.7009 | 10.4515 | 1.0000 | Collectively, our results demonstrate that nuclear translocation and activation of NF-kappa B rank among the short-term cellular responses elicited following proteinCD30 ligation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4193 | 30.9222 | 10.7621 | This chronic inflammatory reaction results from a sequence of events that begins with the trapping of proteinlow density lipoprotein ( LDL ) in the subendothelial space of the artery wall . |
| 3.1594 | 30.9078 | 10.9784 | This chronic inflammatory reaction results from a sequence of events that begins with the trapping of proteinlow density lipoprotein ( LDL ) in the subendothelial space of the artery wall . |
| 0.9781 | 1.0000 | 0.9891 | This chronic inflammatory reaction results from a sequence of events that begins with the trapping of low density lipoprotein ( proteinLDL ) in the subendothelial space of the artery wall . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5415 | 20.3371 | 0.9999 | The trapped LDL is seeded with oxidative species released by the overlying endothelium , and lipid oxidation is initiated within the LDL particle. Some of the lipids that result lead to the activation of NFkB-like transcription factors that cause the expression of genes whose protein products mediate monocyte binding , monocyte chemotaxis into the subendothelial space , and conversion into cell_typemacrophages . |
| 2.4402 | 20.6296 | 1.0000 | The trapped LDL is seeded with oxidative species released by the overlying endothelium , and lipid oxidation is initiated within the LDL particle. Some of the lipids that result lead to the activation of NFkB-like transcription factors that cause the expression of genes whose proteinprotein products mediate monocyte binding , monocyte chemotaxis into the subendothelial space , and conversion into macrophages . |
| 1.6304 | 40.9969 | 0.9999 | The trapped LDL is seeded with oxidative species released by the overlying endothelium , and lipid oxidation is initiated within the LDL particle. Some of the lipids that result lead to the activation of proteinNFkB-like transcription factors that cause the expression of genes whose protein products mediate monocyte binding , monocyte chemotaxis into the subendothelial space , and conversion into macrophages . |
| 2.7651 | 30.0401 | 0.9977 | The trapped LDL is seeded with oxidative species released by the overlying endothelium , and lipid oxidation is initiated within the proteinLDL particle. Some of the lipids that result lead to the activation of NFkB-like transcription factors that cause the expression of genes whose protein products mediate monocyte binding , monocyte chemotaxis into the subendothelial space , and conversion into macrophages . |
| 1.7650 | 10.3867 | 1.0000 | The trapped proteinLDL is seeded with oxidative species released by the overlying endothelium , and lipid oxidation is initiated within the LDL particle. Some of the lipids that result lead to the activation of NFkB-like transcription factors that cause the expression of genes whose protein products mediate monocyte binding , monocyte chemotaxis into the subendothelial space , and conversion into macrophages . |
| The trapped LDL is seeded with oxidative species released by the overlying endothelium , and lipid oxidation is initiated within the LDL particle. Some of the lipids that result lead to the activation of NFkB-like transcription factors that cause the expression of genes whose protein products mediate monocyte binding , cell_typemonocyte chemotaxis into the subendothelial space , and conversion into macrophages . | |||
| The trapped LDL is seeded with oxidative species released by the overlying endothelium , and lipid oxidation is initiated within the LDL particle. Some of the lipids that result lead to the activation of NFkB-like proteintranscription factors that cause the expression of genes whose protein products mediate monocyte binding , monocyte chemotaxis into the subendothelial space , and conversion into macrophages . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6094 | 10.0317 | 1.0000 | At least 1 DNAmajor gene modulates the oxidation of LDL lipids and/or the biologic response to these lipids. |
| 0.8795 | 1.0000 | 1.0000 | At least 1 major gene modulates the oxidation of proteinLDL lipids and/or the biologic response to these lipids. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2588 | 20.2102 | 1.0000 | The inverse relation between high density lipoprotein ( HDL ) and atherosclerotic events may in part be due to enzymes associated with HDL that destroy the biologically active lipids generated in proteinLDL . |
| 1.7208 | 10.9641 | 1.0000 | The inverse relation between high density lipoprotein ( HDL ) and atherosclerotic events may in part be due to enzymes associated with proteinHDL that destroy the biologically active lipids generated in LDL . |
| 1.5019 | 30.5998 | 0.9999 | The inverse relation between proteinhigh density lipoprotein ( HDL ) and atherosclerotic events may in part be due to enzymes associated with HDL that destroy the biologically active lipids generated in LDL . |
| 0.9490 | 1.0000 | 1.0000 | The inverse relation between high density lipoprotein ( proteinHDL ) and atherosclerotic events may in part be due to enzymes associated with HDL that destroy the biologically active lipids generated in LDL . |
| The inverse relation between high density lipoprotein ( HDL ) and atherosclerotic events may in part be due to proteinenzymes associated with HDL that destroy the biologically active lipids generated in LDL . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5240 | 10.9757 | 1.0000 | Estrogen and proteinprogesterone receptors in vernal keratoconjunctivitis . |
| proteinEstrogen and progesterone receptors in vernal keratoconjunctivitis . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6932 | 10.4707 | 1.0000 | METHODS: The authors evaluated tarsal and bulbar conjunctival biopsies from seven patients with severe and symptomatic VKC for the presence of estrogen and proteinprogesterone receptors by using monoclonal antibodies with a peroxidase-antiperoxidase technique . |
| 1.6590 | 10.9153 | 1.0000 | METHODS: The authors evaluated tarsal and bulbar conjunctival biopsies from seven patients with severe and symptomatic VKC for the presence of estrogen and progesterone receptors by using proteinmonoclonal antibodies with a peroxidase-antiperoxidase technique . |
| 0.9076 | 1.0000 | 1.0000 | METHODS: The authors evaluated tarsal and bulbar conjunctival biopsies from seven patients with severe and symptomatic VKC for the presence of proteinestrogen and progesterone receptors by using monoclonal antibodies with a peroxidase-antiperoxidase technique . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8750 | 0.9978 | 1.0000 | RESULTS: Both the epithelium and subepithelium of the tarsal and bulbar conjunctiva of patients with VKC , but not those of four nonatopic control subjects , showed intense positive staining for estrogen and proteinprogesterone receptors . |
| 0.8495 | 1.0000 | 1.0000 | RESULTS: Both the epithelium and subepithelium of the tarsal and bulbar conjunctiva of patients with VKC , but not those of four nonatopic control subjects , showed intense positive staining for proteinestrogen and progesterone receptors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0397 | 20.0029 | 10.4271 | Immunofluorescence colocalization of both estrogen and progesterone receptors with proteineosinophil cationic protein showed that approximately 70% of positive cells were eosinophils . |
| 1.5743 | 10.5508 | 0.9999 | Immunofluorescence colocalization of both estrogen and progesterone receptors with eosinophil cationic protein showed that approximately 70% of positive cells were cell_typeeosinophils . |
| 1.4471 | 10.3904 | 0.9999 | Immunofluorescence colocalization of both estrogen and proteinprogesterone receptors with eosinophil cationic protein showed that approximately 70% of positive cells were eosinophils . |
| 0.7315 | 1.0000 | 1.0000 | Immunofluorescence colocalization of both proteinestrogen and progesterone receptors with eosinophil cationic protein showed that approximately 70% of positive cells were eosinophils . |
| Immunofluorescence colocalization of both estrogen and progesterone receptors with eosinophil cationic protein showed that approximately 70% of cell_typepositive cells were eosinophils . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6463 | 10.8350 | 1.0000 | CONCLUSIONS: Sexual hormones , through their receptors , may influence the activity of cell_typeeosinophils in patients with VKC . |
| 1.6424 | 10.2783 | 1.0000 | CONCLUSIONS: Sexual hormones , through their proteinreceptors , may influence the activity of eosinophils in patients with VKC . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6580 | 20.4718 | 10.8115 | CIITA activates the expression of DNAMHC class II genes in mouse T cells. |
| 0.9562 | 1.0000 | 1.0000 | proteinCIITA activates the expression of MHC class II genes in mouse T cells. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3448 | 30.1758 | 10.8947 | It has long been a puzzle that MHC class II molecules are expressed in human T cells after activation but not in cell_typemouse T cells ; this expression is believed to play a role in the cell mediated immune response . |
| 4.0555 | 30.0536 | 10.6963 | It has long been a puzzle that proteinMHC class II molecules are expressed in human T cells after activation but not in mouse T cells ; this expression is believed to play a role in the cell mediated immune response . |
| 3.5487 | 20.7743 | 10.7916 | It has long been a puzzle that MHC class II molecules are expressed in cell_typehuman T cells after activation but not in mouse T cells ; this expression is believed to play a role in the cell mediated immune response . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6120 | 30.5368 | 10.6630 | Recently the MHC class II transactivator ( CIITA ) has been reported to be a major regulatory factor for both the constitutive and IFN inducible expression of DNAMHC class II genes . |
| 2.5138 | 20.9874 | 10.5724 | Recently the proteinMHC class II transactivator ( CIITA ) has been reported to be a major regulatory factor for both the constitutive and IFN inducible expression of MHC class II genes . |
| 0.4985 | 1.0000 | 1.0000 | Recently the MHC class II transactivator ( DNACIITA ) has been reported to be a major regulatory factor for both the constitutive and IFN inducible expression of MHC class II genes . |
| Recently the MHC class II transactivator ( proteinCIITA ) has been reported to be a major regulatory factor for both the constitutive and IFN inducible expression of MHC class II genes . | |||
| Recently the MHC class II transactivator ( CIITA ) has been reported to be a proteinmajor regulatory factor for both the constitutive and IFN inducible expression of MHC class II genes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2947 | 20.5351 | 10.8520 | Here we show that cell_typehuman T cells expressing MHC class II have CIITA transcripts while MHC class II-negative human T cells and mouse T cells do not. |
| 1.4116 | 10.6595 | 0.9736 | Here we show that human T cells expressing MHC class II have proteinCIITA transcripts while MHC class II-negative human T cells and mouse T cells do not. |
| 4.2466 | 20.9307 | 20.4238 | Here we show that human T cells expressing MHC class II have CIITA transcripts while cell_lineMHC class II-negative human T cells and mouse T cells do not. |
| 3.3358 | 20.3196 | 10.6207 | Here we show that human T cells expressing proteinMHC class II have CIITA transcripts while MHC class II-negative human T cells and mouse T cells do not. |
| 1.5105 | 10.4724 | 0.9996 | Here we show that human T cells expressing MHC class II have RNACIITA transcripts while MHC class II-negative human T cells and mouse T cells do not. |
| Here we show that human T cells expressing MHC class II have CIITA transcripts while MHC class II-negative human T cells and cell_typemouse T cells do not. | |||
| Here we show that human T cells expressing MHC class II have CIITA transcripts while MHC class II-negative cell_typehuman T cells and mouse T cells do not. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4878 | 20.6817 | 20.0030 | The expression of DNAMHC class II genes in mouse T cells can be reconstituted upon transfection with the human CIITA cDNA . |
| 3.0673 | 20.7108 | 10.0178 | The expression of MHC class II genes in mouse T cells can be reconstituted upon transfection with the DNAhuman CIITA cDNA . |
| 2.7447 | 10.8788 | 10.7374 | The expression of MHC class II genes in cell_typemouse T cells can be reconstituted upon transfection with the human CIITA cDNA . |
| 0.8746 | 1.0000 | 0.9865 | The expression of MHC class II genes in mouse T cells can be reconstituted upon transfection with the human proteinCIITA cDNA . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9290 | 20.5037 | 10.5235 | These data indicate that the expression of CIITA explains the expression or lack of expression of proteinMHC class II in human and mouse T cells respectively. |
| 1.5694 | 10.6424 | 1.0000 | These data indicate that the expression of proteinCIITA explains the expression or lack of expression of MHC class II in human and mouse T cells respectively. |
| These data indicate that the expression of CIITA explains the expression or lack of expression of MHC class II in cell_typehuman and mouse T cells respectively. | |||
| These data indicate that the expression of CIITA explains the expression or lack of expression of MHC class II in human and cell_typemouse T cells respectively. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5900 | 20.4843 | 10.9752 | Anti-Ro(SSA) autoantibodies are associated with DNAT cell receptor beta genes in systemic lupus erythematosus patients . |
| 0.7473 | 0.9943 | 0.9999 | proteinAnti-Ro(SSA) autoantibodies are associated with T cell receptor beta genes in systemic lupus erythematosus patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8980 | 1.0000 | 1.0000 | Several of the heterogeneous clinical manifestations of systemic lupus erythematosus have been associated with specific proteinautoantibodies . |
| 1.4987 | 10.8266 | 0.9998 | Several of the heterogeneous clinical manifestations of systemic lupus erythematosus have been associated with proteinspecific autoantibodies . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0178 | 10.8527 | 10.7834 | Associations between proteinHLA class II antigens and autoantibodies to the ribonucleoproteins Ro(SSA) and La(SSB) have been reported in these patients. |
| 1.4640 | 10.4879 | 1.0000 | Associations between HLA class II antigens and autoantibodies to the proteinribonucleoproteins Ro(SSA) and La(SSB) have been reported in these patients. |
| 0.9281 | 1.0000 | 1.0000 | Associations between HLA class II antigens and proteinautoantibodies to the ribonucleoproteins Ro(SSA) and La(SSB) have been reported in these patients. |
| 0.6208 | 0.9999 | 1.0000 | Associations between HLA class II antigens and autoantibodies to the ribonucleoproteins proteinRo(SSA) and La(SSB) have been reported in these patients. |
| 0.5932 | 1.0000 | 1.0000 | Associations between HLA class II antigens and autoantibodies to the ribonucleoproteins Ro(SSA) and proteinLa(SSB) have been reported in these patients. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6827 | 30.2686 | 10.9883 | Because HLA class II molecules present antigen to T cell receptors ( TCRs ), we have searched for a TCR gene associated with the production of proteinanti- Ro(SSA) antibodies . |
| 3.4443 | 20.3555 | 10.4299 | Because HLA class II molecules present antigen to proteinT cell receptors ( TCRs ), we have searched for a TCR gene associated with the production of anti- Ro(SSA) antibodies . |
| 2.2791 | 10.9314 | 10.0714 | Because proteinHLA class II molecules present antigen to T cell receptors ( TCRs ), we have searched for a TCR gene associated with the production of anti- Ro(SSA) antibodies . |
| 2.0264 | 20.9680 | 1.0000 | Because HLA class II molecules present antigen to T cell receptors ( TCRs ), we have searched for a DNATCR gene associated with the production of anti- Ro(SSA) antibodies . |
| 0.9635 | 1.0000 | 1.0000 | Because HLA class II molecules present antigen to T cell receptors ( proteinTCRs ), we have searched for a TCR gene associated with the production of anti- Ro(SSA) antibodies . |
| Because HLA class II molecules present antigen to T cell receptors ( TCRs ), we have searched for a TCR gene associated with the production of anti- proteinRo(SSA) antibodies . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5279 | 30.0431 | 10.9791 | A pair of restriction fragment length polymorphisms ( RFLPs ), one of which hybridizes to the TCR constant region C beta 1 and the other to the DNAC beta 2 gene , has been identified, suggesting these may be genotypic markers for an extended region of the TCR beta locus . |
| 4.4271 | 30.6943 | 10.7708 | A pair of restriction fragment length polymorphisms ( RFLPs ), one of which hybridizes to the DNATCR constant region C beta 1 and the other to the C beta 2 gene , has been identified, suggesting these may be genotypic markers for an extended region of the TCR beta locus . |
| 4.3099 | 20.4742 | 10.9091 | A pair of DNArestriction fragment length polymorphisms ( RFLPs ), one of which hybridizes to the TCR constant region C beta 1 and the other to the C beta 2 gene , has been identified, suggesting these may be genotypic markers for an extended region of the TCR beta locus . |
| 4.0274 | 30.3343 | 10.7166 | A pair of restriction fragment length polymorphisms ( RFLPs ), one of which hybridizes to the TCR constant region C beta 1 and the other to the C beta 2 gene , has been identified, suggesting these may be genotypic markers for an extended region of the DNATCR beta locus . |
| 0.9301 | 1.0000 | 1.0000 | A pair of restriction fragment length polymorphisms ( DNARFLPs ), one of which hybridizes to the TCR constant region C beta 1 and the other to the C beta 2 gene , has been identified, suggesting these may be genotypic markers for an extended region of the TCR beta locus . |
| 1.5907 | 0.9863 | 10.9925 | A pair of restriction fragment length polymorphisms ( RFLPs ), one of which hybridizes to the TCR constant region DNAC beta 1 and the other to the C beta 2 gene , has been identified, suggesting these may be genotypic markers for an extended region of the TCR beta locus . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5992 | 10.0279 | 1.0000 | This DNARFLP pair occurs in 76% of patients with Ro(SSA) precipitins, 84% of anti- Ro(SSA) -positive patients lacking La(SSB) precipitins , but only 41% of the patients lacking both precipitins (P = 0.0004). |
| 0.9073 | 1.0000 | 1.0000 | This RFLP pair occurs in 76% of patients with Ro(SSA) precipitins, 84% of anti- proteinRo(SSA) -positive patients lacking La(SSB) precipitins , but only 41% of the patients lacking both precipitins (P = 0.0004). |
| 0.8253 | 1.0000 | 1.0000 | This RFLP pair occurs in 76% of patients with Ro(SSA) precipitins, 84% of anti- Ro(SSA) -positive patients lacking La(SSB) precipitins , but only 41% of the patients lacking both proteinprecipitins (P = 0.0004). |
| 2.3109 | 20.0765 | 1.0000 | This RFLP pair occurs in 76% of patients with Ro(SSA) precipitins, 84% of anti- Ro(SSA) -positive patients lacking proteinLa(SSB) precipitins , but only 41% of the patients lacking both precipitins (P = 0.0004). |
| This RFLP pair occurs in 76% of patients with Ro(SSA) precipitins, 84% of anti- Ro(SSA) -positive patients lacking La(SSB) proteinprecipitins , but only 41% of the patients lacking both precipitins (P = 0.0004). | |||
| This RFLP pair occurs in 76% of patients with Ro(SSA) precipitins, 84% of anti- Ro(SSA) -positive patients lacking proteinLa(SSB) precipitins , but only 41% of the patients lacking both precipitins (P = 0.0004). | |||
| This RFLP pair occurs in 76% of patients with proteinRo(SSA) precipitins, 84% of anti- Ro(SSA) -positive patients lacking La(SSB) precipitins , but only 41% of the patients lacking both precipitins (P = 0.0004). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2465 | 20.9584 | 10.5278 | This disproportionate occurrence in a subset of lupus patients indicates that these RFLPs are not disease susceptibility markers, but rather are important markers for TCR genes whose products are involved in the production of proteinanti- Ro(SSA) antibodies . |
| 2.3255 | 20.5591 | 1.0000 | This disproportionate occurrence in a subset of lupus patients indicates that these RFLPs are not disease susceptibility markers, but rather are important markers for DNATCR genes whose products are involved in the production of anti- Ro(SSA) antibodies . |
| 1.6786 | 10.3978 | 1.0000 | This disproportionate occurrence in a subset of lupus patients indicates that these DNARFLPs are not disease susceptibility markers, but rather are important markers for TCR genes whose products are involved in the production of anti- Ro(SSA) antibodies . |
| This disproportionate occurrence in a subset of lupus patients indicates that these RFLPs are not disease susceptibility markers, but rather are important markers for TCR genes whose products are involved in the production of anti- proteinRo(SSA) antibodies . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0734 | 20.2231 | 10.5663 | The majority of patients who have these RFLPs and proteinHLA class II antigens previously associated with the anti- Ro(SSA) response make this antibody, suggesting that interactions between products of these loci occur in response to Ro(SSA) . |
| 1.5378 | 10.3635 | 1.0000 | The majority of patients who have these DNARFLPs and HLA class II antigens previously associated with the anti- Ro(SSA) response make this antibody, suggesting that interactions between products of these loci occur in response to Ro(SSA) . |
| 0.9295 | 1.0000 | 1.0000 | The majority of patients who have these RFLPs and HLA class II antigens previously associated with the anti- proteinRo(SSA) response make this antibody, suggesting that interactions between products of these loci occur in response to Ro(SSA) . |
| 0.8565 | 1.0000 | 1.0000 | The majority of patients who have these RFLPs and HLA class II antigens previously associated with the anti- Ro(SSA) response make this antibody, suggesting that interactions between products of these loci occur in response to proteinRo(SSA) . |
| 1.2340 | 10.9988 | 0.9999 | The majority of patients who have these RFLPs and HLA class II antigens previously associated with the proteinanti- Ro(SSA) response make this antibody, suggesting that interactions between products of these loci occur in response to Ro(SSA) . |
| The majority of patients who have these RFLPs and HLA class II antigens previously associated with the anti- Ro(SSA) response make this antibody, suggesting that interactions between products of these DNAloci occur in response to Ro(SSA) . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8821 | 20.6828 | 10.9560 | Inhibition of NF-AT -dependent transcription by NF-kappa B : implications for differential gene expression in cell_typeT helper cell subsets . |
| 2.0363 | 20.1604 | 1.0000 | Inhibition of NF-AT -dependent transcription by proteinNF-kappa B : implications for differential gene expression in T helper cell subsets . |
| 1.4649 | 10.4748 | 1.0000 | Inhibition of proteinNF-AT -dependent transcription by NF-kappa B : implications for differential gene expression in T helper cell subsets . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9751 | 1.0000 | 1.0000 | Activation of individual CD4+ T cells results in differential lymphokine expression : interleukin 2 ( proteinIL-2 ) is preferentially produced by T helper type 1 (TH1) cells , which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells , which are essential for humoral immunity . |
| 0.9385 | 1.0000 | 1.0000 | Activation of individual CD4+ T cells results in differential lymphokine expression : interleukin 2 ( IL-2 ) is preferentially produced by T helper type 1 (TH1) cells , which are involved in cell-mediated immune responses, whereas proteinIL-4 is synthesized by TH2 cells , which are essential for humoral immunity . |
| 0.8335 | 1.0000 | 1.0000 | Activation of individual CD4+ T cells results in differential proteinlymphokine expression : interleukin 2 ( IL-2 ) is preferentially produced by T helper type 1 (TH1) cells , which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells , which are essential for humoral immunity . |
| 0.7893 | 1.0000 | 1.0000 | Activation of individual CD4+ T cells results in differential lymphokine expression : proteininterleukin 2 ( IL-2 ) is preferentially produced by T helper type 1 (TH1) cells , which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells , which are essential for humoral immunity . |
| 7.9361 | 30.9189 | 20.6497 | Activation of individual CD4+ T cells results in differential lymphokine expression : interleukin 2 ( IL-2 ) is preferentially produced by cell_typeT helper type 1 (TH1) cells , which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells , which are essential for humoral immunity . |
| 3.4118 | 20.5276 | 10.9508 | Activation of individual cell_typeCD4+ T cells results in differential lymphokine expression : interleukin 2 ( IL-2 ) is preferentially produced by T helper type 1 (TH1) cells , which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells , which are essential for humoral immunity . |
| 2.1605 | 20.6039 | 0.9999 | Activation of individual CD4+ T cells results in differential lymphokine expression : interleukin 2 ( IL-2 ) is preferentially produced by T helper type 1 (TH1) cells , which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by cell_typeTH2 cells , which are essential for humoral immunity . |
| Activation of individual CD4+ T cells results in differential lymphokine expression : interleukin 2 ( IL-2 ) is preferentially produced by T helper type 1 (TH1) cells , which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by cell_lineTH2 cells , which are essential for humoral immunity . | |||
| Activation of individual CD4+ T cells results in differential lymphokine expression : interleukin 2 ( IL-2 ) is preferentially produced by cell_lineT helper type 1 (TH1) cells , which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells , which are essential for humoral immunity . | |||
| Activation of individual cell_lineCD4+ T cells results in differential lymphokine expression : interleukin 2 ( IL-2 ) is preferentially produced by T helper type 1 (TH1) cells , which are involved in cell-mediated immune responses, whereas IL-4 is synthesized by TH2 cells , which are essential for humoral immunity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2189 | 10.8532 | 10.4255 | The proteinCa(2+) -dependent factor NF-ATp plays a key role in the inducible transcription of both these lymphokine genes . |
| 2.1306 | 20.4829 | 0.9999 | The Ca(2+) -dependent factor NF-ATp plays a key role in the inducible transcription of both these DNAlymphokine genes . |
| 0.9833 | 1.0000 | 1.0000 | The Ca(2+) -dependent factor proteinNF-ATp plays a key role in the inducible transcription of both these lymphokine genes . |
| 1.9183 | 20.6281 | 0.9810 | The Ca(2+) -dependent factor NF-ATp plays a key role in the inducible transcription of both these proteinlymphokine genes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.4104 | 20.5225 | 10.9213 | However, while IL2 expression requires the contribution of Ca(2+)- and proteinprotein kinase C -dependent signals , we report that activation of human IL4 transcription through the Ca(2+)-dependent pathway is diminished by protein kinase C stimulation in Jurkat T cells . |
| 4.3556 | 20.6255 | 10.9259 | However, while IL2 expression requires the contribution of Ca(2+)- and protein kinase C -dependent signals , we report that activation of human IL4 transcription through the Ca(2+)-dependent pathway is diminished by protein kinase C stimulation in cell_lineJurkat T cells . |
| 3.6588 | 20.7982 | 10.8496 | However, while IL2 expression requires the contribution of Ca(2+)- and protein kinase C -dependent signals , we report that activation of human IL4 transcription through the Ca(2+)-dependent pathway is diminished by proteinprotein kinase C stimulation in Jurkat T cells . |
| 0.9022 | 1.0000 | 1.0000 | However, while proteinIL2 expression requires the contribution of Ca(2+)- and protein kinase C -dependent signals , we report that activation of human IL4 transcription through the Ca(2+)-dependent pathway is diminished by protein kinase C stimulation in Jurkat T cells . |
| 0.9196 | 0.9999 | 1.0000 | However, while IL2 expression requires the contribution of Ca(2+)- and protein kinase C -dependent signals , we report that activation of human proteinIL4 transcription through the Ca(2+)-dependent pathway is diminished by protein kinase C stimulation in Jurkat T cells . |
| However, while IL2 expression requires the contribution of Ca(2+)- and protein kinase C -dependent signals , we report that activation of proteinhuman IL4 transcription through the Ca(2+)-dependent pathway is diminished by protein kinase C stimulation in Jurkat T cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8098 | 20.5230 | 10.8664 | This phenomenon is due to mutually exclusive binding of NF-ATp and NF-kappa B to the P sequence , an element located 69 bp upstream of the DNAIL4 transcription initiation site . |
| 3.6195 | 20.4897 | 10.8147 | This phenomenon is due to mutually exclusive binding of NF-ATp and NF-kappa B to the P sequence , an element located DNA69 bp upstream of the IL4 transcription initiation site . |
| 1.6003 | 10.3813 | 1.0000 | This phenomenon is due to mutually exclusive binding of proteinNF-ATp and NF-kappa B to the P sequence , an element located 69 bp upstream of the IL4 transcription initiation site . |
| 1.5877 | 10.1762 | 1.0000 | This phenomenon is due to mutually exclusive binding of NF-ATp and proteinNF-kappa B to the P sequence , an element located 69 bp upstream of the IL4 transcription initiation site . |
| 1.4116 | 10.9174 | 1.0000 | This phenomenon is due to mutually exclusive binding of NF-ATp and NF-kappa B to the DNAP sequence , an element located 69 bp upstream of the IL4 transcription initiation site . |
| 2.0454 | 20.0711 | 0.9981 | This phenomenon is due to mutually exclusive binding of NF-ATp and NF-kappa B to the P sequence , an element located 69 bp upstream of the proteinIL4 transcription initiation site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5054 | 20.7381 | 10.8209 | Human IL4 promoter -mediated transcription is downregulated in Jurkat cells stimulated with the proteinNF-kappa B -activating cytokine tumor necrosis factor alpha and suppressed in RelA -overexpressing cells . |
| 2.5975 | 20.7972 | 10.9009 | Human IL4 promoter -mediated transcription is downregulated in Jurkat cells stimulated with the NF-kappa B -activating cytokine tumor necrosis factor alpha and suppressed in cell_lineRelA -overexpressing cells . |
| 2.0347 | 20.1456 | 0.9955 | Human IL4 promoter -mediated transcription is downregulated in Jurkat cells stimulated with the NF-kappa B -activating cytokine tumor necrosis factor alpha and suppressed in proteinRelA -overexpressing cells . |
| 1.9431 | 20.4999 | 0.9151 | Human IL4 promoter -mediated transcription is downregulated in Jurkat cells stimulated with the proteinNF-kappa B -activating cytokine tumor necrosis factor alpha and suppressed in RelA -overexpressing cells . |
| 1.3254 | 0.8660 | 10.7058 | Human IL4 promoter -mediated transcription is downregulated in Jurkat cells stimulated with the NF-kappa B -activating cytokine proteintumor necrosis factor alpha and suppressed in RelA -overexpressing cells . |
| 1.3004 | 10.8304 | 0.9999 | Human IL4 promoter -mediated transcription is downregulated in cell_lineJurkat cells stimulated with the NF-kappa B -activating cytokine tumor necrosis factor alpha and suppressed in RelA -overexpressing cells . |
| 1.4876 | 10.4393 | 0.9999 | Human DNAIL4 promoter -mediated transcription is downregulated in Jurkat cells stimulated with the NF-kappa B -activating cytokine tumor necrosis factor alpha and suppressed in RelA -overexpressing cells . |
| 1.0448 | 10.3974 | 0.9751 | Human proteinIL4 promoter -mediated transcription is downregulated in Jurkat cells stimulated with the NF-kappa B -activating cytokine tumor necrosis factor alpha and suppressed in RelA -overexpressing cells . |
| DNAHuman IL4 promoter -mediated transcription is downregulated in Jurkat cells stimulated with the NF-kappa B -activating cytokine tumor necrosis factor alpha and suppressed in RelA -overexpressing cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2151 | 20.5296 | 10.8455 | In contrast, proteinprotein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a mouse P sequence , which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA . |
| 3.5735 | 20.9514 | 10.7503 | In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a DNAhuman IL4 promoter containing a mouse P sequence , which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA . |
| 3.5429 | 20.6922 | 10.5856 | In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a DNAmouse P sequence , which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA . |
| 2.0892 | 20.1007 | 0.9994 | In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a mouse P sequence , which is a higher-affinity site for NF-ATp and a DNAlower-affinity site for RelA . |
| 2.0402 | 20.6748 | 0.9993 | In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a mouse P sequence , which is a DNAhigher-affinity site for NF-ATp and a lower-affinity site for RelA . |
| 1.6079 | 10.1009 | 1.0000 | In contrast, protein kinase C stimulation or proteinRelA overexpression does not affect the activity of a human IL4 promoter containing a mouse P sequence , which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA . |
| 0.9068 | 0.9999 | 1.0000 | In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a mouse P sequence , which is a higher-affinity site for proteinNF-ATp and a lower-affinity site for RelA . |
| 0.8071 | 0.9999 | 1.0000 | In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a mouse P sequence , which is a higher-affinity site for NF-ATp and a lower-affinity site for proteinRelA . |
| 0.6391 | 0.9999 | 0.9997 | In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human IL4 promoter containing a mouse DNAP sequence , which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA . |
| 0.7274 | 0.9997 | 0.9997 | In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a human DNAIL4 promoter containing a mouse P sequence , which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA . |
| In contrast, protein kinase C stimulation or RelA overexpression does not affect the activity of a proteinhuman IL4 promoter containing a mouse P sequence , which is a higher-affinity site for NF-ATp and a lower-affinity site for RelA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6836 | 20.9225 | 10.8346 | Thus, competition between two general transcriptional activators , RelA and NF-ATp , mediates the inhibitory effect of proteinprotein kinase C stimulation on IL4 expression and may contribute to differential gene expression in TH cells . |
| 1.7179 | 10.5049 | 1.0000 | Thus, competition between two general transcriptional activators , proteinRelA and NF-ATp , mediates the inhibitory effect of protein kinase C stimulation on IL4 expression and may contribute to differential gene expression in TH cells . |
| 1.6117 | 10.5188 | 1.0000 | Thus, competition between two general transcriptional activators , RelA and NF-ATp , mediates the inhibitory effect of protein kinase C stimulation on proteinIL4 expression and may contribute to differential gene expression in TH cells . |
| 1.3751 | 10.4281 | 1.0000 | Thus, competition between two general proteintranscriptional activators , RelA and NF-ATp , mediates the inhibitory effect of protein kinase C stimulation on IL4 expression and may contribute to differential gene expression in TH cells . |
| 0.8899 | 1.0000 | 1.0000 | Thus, competition between two general transcriptional activators , RelA and proteinNF-ATp , mediates the inhibitory effect of protein kinase C stimulation on IL4 expression and may contribute to differential gene expression in TH cells . |
| 2.2781 | 20.9623 | 0.9999 | Thus, competition between two general transcriptional activators , RelA and NF-ATp , mediates the inhibitory effect of protein kinase C stimulation on IL4 expression and may contribute to differential gene expression in cell_typeTH cells . |
| Thus, competition between two general transcriptional activators , RelA and NF-ATp , mediates the inhibitory effect of protein kinase C stimulation on IL4 expression and may contribute to differential gene expression in cell_lineTH cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.3430 | 10.3024 | 1.0000 | Regulation of the balance of proteincytokine production and the signal transducer and activator of transcription ( STAT ) transcription factor activity by cytokines and inflammatory synovial fluids. |
| 0.8292 | 0.9998 | 1.0000 | Regulation of the balance of cytokine production and the signal transducer and activator of transcription ( STAT ) transcription factor activity by proteincytokines and inflammatory synovial fluids. |
| 5.7182 | 10.5864 | 30.8088 | Regulation of the balance of cytokine production and the proteinsignal transducer and activator of transcription ( STAT ) transcription factor activity by cytokines and inflammatory synovial fluids. |
| Regulation of the balance of cytokine production and the signal transducer and activator of transcription ( proteinSTAT ) transcription factor activity by cytokines and inflammatory synovial fluids. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8118 | 10.0782 | 1.0000 | The balance between type 1 and 2 T helper cell cytokine production plays an important role in several animal models of autoimmunity, and skewed patterns of proteincytokine expression have been described in human inflammatory diseases . |
| 0.9552 | 0.9999 | 1.0000 | The balance between type 1 and 2 T helper cell proteincytokine production plays an important role in several animal models of autoimmunity, and skewed patterns of cytokine expression have been described in human inflammatory diseases . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.9802 | 10.6994 | 30.0640 | Many cytokines activate proteinsignal transducer and activation of transcription ( STAT ) transcription factors , which, in turn, activate transcription of inflammatory effector genes. |
| 0.6895 | 0.9922 | 0.9998 | Many proteincytokines activate signal transducer and activation of transcription ( STAT ) transcription factors , which, in turn, activate transcription of inflammatory effector genes. |
| Many cytokines activate signal transducer and activation of transcription ( proteinSTAT ) transcription factors , which, in turn, activate transcription of inflammatory effector genes. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6809 | 20.7793 | 10.9182 | We used cell_linemononuclear cell priming cultures and inflammatory synovial fluids ( SFs ) derived from arthritis patients to examine the regulation of cytokine production and STAT activity by an inflammatory synovial microenvironment . |
| 1.6529 | 10.6761 | 1.0000 | We used mononuclear cell priming cultures and inflammatory synovial fluids ( SFs ) derived from arthritis patients to examine the regulation of cytokine production and proteinSTAT activity by an inflammatory synovial microenvironment . |
| 0.8988 | 0.9999 | 1.0000 | We used mononuclear cell priming cultures and inflammatory synovial fluids ( SFs ) derived from arthritis patients to examine the regulation of proteincytokine production and STAT activity by an inflammatory synovial microenvironment . |
| We used mononuclear cell priming cultures and inflammatory synovial fluids ( cell_typeSFs ) derived from arthritis patients to examine the regulation of cytokine production and STAT activity by an inflammatory synovial microenvironment . | |||
| We used mononuclear cell priming cultures and cell_typeinflammatory synovial fluids ( SFs ) derived from arthritis patients to examine the regulation of cytokine production and STAT activity by an inflammatory synovial microenvironment . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2059 | 20.3432 | 1.0000 | Exposure to SFs during priming resulted in an 81% inhibition of proteininterferon (IFN)-gamma , but not interleukin (IL) 4 , production by effector cells generated in priming cultures. |
| 2.1914 | 20.0890 | 0.9999 | Exposure to SFs during priming resulted in an 81% inhibition of interferon (IFN)-gamma , but not proteininterleukin (IL) 4 , production by effector cells generated in priming cultures. |
| 1.4484 | 10.8317 | 0.9999 | Exposure to SFs during priming resulted in an 81% inhibition of interferon (IFN)-gamma , but not interleukin (IL) 4 , production by cell_typeeffector cells generated in priming cultures. |
| 1.5726 | 20.2025 | 0.7286 | Exposure to SFs during priming resulted in an 81% inhibition of interferon (IFN)-gamma , but not proteininterleukin (IL) 4 , production by effector cells generated in priming cultures. |
| Exposure to cell_typeSFs during priming resulted in an 81% inhibition of interferon (IFN)-gamma , but not interleukin (IL) 4 , production by effector cells generated in priming cultures. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7401 | 10.1365 | 1.0000 | SF suppression was mediated by proteinIL-4 and IL-10 and inhibition of IL-12 expression , and it was reversed in a dominant fashion by exogenous IL-12. |
| 1.6381 | 10.8163 | 1.0000 | SF suppression was mediated by IL-4 and IL-10 and inhibition of proteinIL-12 expression , and it was reversed in a dominant fashion by exogenous IL-12. |
| 0.9668 | 1.0000 | 1.0000 | SF suppression was mediated by IL-4 and proteinIL-10 and inhibition of IL-12 expression , and it was reversed in a dominant fashion by exogenous IL-12. |
| 0.6487 | 1.0000 | 1.0000 | proteinSF suppression was mediated by IL-4 and IL-10 and inhibition of IL-12 expression , and it was reversed in a dominant fashion by exogenous IL-12. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7921 | 10.0029 | 1.0000 | SFs blocked the sustained activity of transcription factor Stat1 , but not proteinStat3 , during the priming period, and Stat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of IFN-gamma production . |
| 1.7220 | 10.3273 | 1.0000 | SFs blocked the sustained activity of transcription factor Stat1 , but not Stat3 , during the priming period, and Stat1 activity was differentially regulated by proteincytokines in parallel with their positive or negative regulation of IFN-gamma production . |
| 1.6349 | 10.8251 | 1.0000 | SFs blocked the sustained activity of transcription factor Stat1 , but not Stat3 , during the priming period, and Stat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of proteinIFN-gamma production . |
| 0.9500 | 1.0000 | 1.0000 | SFs blocked the sustained activity of transcription factor Stat1 , but not Stat3 , during the priming period, and proteinStat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of IFN-gamma production . |
| 2.2615 | 20.5572 | 0.9998 | SFs blocked the sustained activity of proteintranscription factor Stat1 , but not Stat3 , during the priming period, and Stat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of IFN-gamma production . |
| 0.9794 | 1.0000 | 1.0000 | proteinSFs blocked the sustained activity of transcription factor Stat1 , but not Stat3 , during the priming period, and Stat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of IFN-gamma production . |
| 0.9697 | 1.0000 | 1.0000 | SFs blocked the sustained activity of transcription factor proteinStat1 , but not Stat3 , during the priming period, and Stat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of IFN-gamma production . |
| cell_typeSFs blocked the sustained activity of transcription factor Stat1 , but not Stat3 , during the priming period, and Stat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of IFN-gamma production . | |||
| SFs blocked the sustained activity of proteintranscription factor Stat1 , but not Stat3 , during the priming period, and Stat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of IFN-gamma production . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5861 | 10.6609 | 1.0000 | Active Stat3 , but not proteinStat1 , was detected in cells from inflamed joints . |
| 0.8956 | 0.9999 | 1.0000 | Active proteinStat3 , but not Stat1 , was detected in cells from inflamed joints . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6522 | 10.3509 | 0.9999 | These results suggest a role for altered balance of Stat1 and Stat3 transcriptional activity in the regulation of cell_typeT cell differentiation and in the pathogenesis of inflammatory synovitis . |
| 1.7176 | 10.4051 | 1.0000 | These results suggest a role for altered balance of proteinStat1 and Stat3 transcriptional activity in the regulation of T cell differentiation and in the pathogenesis of inflammatory synovitis . |
| 0.9154 | 0.9999 | 1.0000 | These results suggest a role for altered balance of Stat1 and proteinStat3 transcriptional activity in the regulation of T cell differentiation and in the pathogenesis of inflammatory synovitis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4251 | 30.2852 | 10.1770 | Triggering of complement receptors CR1 ( CD35 ) and CR3 ( CD11b/CD18 ) induces nuclear translocation of NF-kappa B ( p50/p65 ) in human monocytes and enhances viral replication in cell_typeHIV-infected monocytic cells . |
| 2.0980 | 20.3745 | 1.0000 | Triggering of complement receptors CR1 ( CD35 ) and CR3 ( CD11b/CD18 ) induces nuclear translocation of proteinNF-kappa B ( p50/p65 ) in human monocytes and enhances viral replication in HIV-infected monocytic cells . |
| 1.8236 | 10.3005 | 1.0000 | Triggering of complement receptors CR1 ( CD35 ) and proteinCR3 ( CD11b/CD18 ) induces nuclear translocation of NF-kappa B ( p50/p65 ) in human monocytes and enhances viral replication in HIV-infected monocytic cells . |
| 1.3719 | 10.7345 | 0.9999 | Triggering of complement receptors CR1 ( CD35 ) and CR3 ( CD11b/CD18 ) induces nuclear translocation of NF-kappa B ( p50/p65 ) in cell_typehuman monocytes and enhances viral replication in HIV-infected monocytic cells . |
| 1.3277 | 20.8590 | 0.9993 | Triggering of proteincomplement receptors CR1 ( CD35 ) and CR3 ( CD11b/CD18 ) induces nuclear translocation of NF-kappa B ( p50/p65 ) in human monocytes and enhances viral replication in HIV-infected monocytic cells . |
| 0.9763 | 1.0000 | 1.0000 | Triggering of complement receptors CR1 ( proteinCD35 ) and CR3 ( CD11b/CD18 ) induces nuclear translocation of NF-kappa B ( p50/p65 ) in human monocytes and enhances viral replication in HIV-infected monocytic cells . |
| 0.9579 | 1.0000 | 1.0000 | Triggering of complement receptors proteinCR1 ( CD35 ) and CR3 ( CD11b/CD18 ) induces nuclear translocation of NF-kappa B ( p50/p65 ) in human monocytes and enhances viral replication in HIV-infected monocytic cells . |
| 0.9370 | 1.0000 | 1.0000 | Triggering of complement receptors CR1 ( CD35 ) and CR3 ( CD11b/CD18 ) induces nuclear translocation of NF-kappa B ( proteinp50/p65 ) in human monocytes and enhances viral replication in HIV-infected monocytic cells . |
| 0.9341 | 1.0000 | 1.0000 | Triggering of complement receptors CR1 ( CD35 ) and CR3 ( proteinCD11b/CD18 ) induces nuclear translocation of NF-kappa B ( p50/p65 ) in human monocytes and enhances viral replication in HIV-infected monocytic cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8829 | 1.0000 | 1.0000 | cell_typeMonocyte/macrophages may harbor HIV in a nonproductive fashion for prolonged periods of time. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7429 | 10.2713 | 1.0000 | Viral gene expression may be reactivated by stimulation of the cells with LPS or proteincytokines such as TNF-alpha in vitro. |
| 1.6615 | 10.7407 | 1.0000 | Viral gene expression may be reactivated by stimulation of the cells with LPS or cytokines such as proteinTNF-alpha in vitro. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5329 | 30.0273 | 10.5606 | The effect of LPS and TNF-alpha is mediated by their ability to induce nuclear translocation of the DNA-binding heterodimer NF-kappa B ( p50/p65 ), which binds to a specific sequence in the DNAHIV-long terminal repeat . |
| 2.1519 | 20.1517 | 0.9997 | The effect of LPS and TNF-alpha is mediated by their ability to induce nuclear translocation of the proteinDNA-binding heterodimer NF-kappa B ( p50/p65 ), which binds to a specific sequence in the HIV-long terminal repeat . |
| 1.6769 | 10.3817 | 1.0000 | The effect of LPS and proteinTNF-alpha is mediated by their ability to induce nuclear translocation of the DNA-binding heterodimer NF-kappa B ( p50/p65 ), which binds to a specific sequence in the HIV-long terminal repeat . |
| 0.9780 | 1.0000 | 1.0000 | The effect of LPS and TNF-alpha is mediated by their ability to induce nuclear translocation of the DNA-binding heterodimer NF-kappa B ( proteinp50/p65 ), which binds to a specific sequence in the HIV-long terminal repeat . |
| 0.9047 | 0.9998 | 0.9999 | The effect of LPS and TNF-alpha is mediated by their ability to induce nuclear translocation of the DNA-binding heterodimer proteinNF-kappa B ( p50/p65 ), which binds to a specific sequence in the HIV-long terminal repeat . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8577 | 20.8337 | 0.9996 | The present study demonstrates that triggering of proteincomplement receptors CR1 ( CD35 ) and CR3 ( CD11b/CD18 ) enhances viral replication in HIV-infected human monocytic cells . |
| 1.6929 | 10.3883 | 1.0000 | The present study demonstrates that triggering of complement receptors CR1 ( CD35 ) and proteinCR3 ( CD11b/CD18 ) enhances viral replication in HIV-infected human monocytic cells . |
| 0.9572 | 1.0000 | 1.0000 | The present study demonstrates that triggering of complement receptors CR1 ( proteinCD35 ) and CR3 ( CD11b/CD18 ) enhances viral replication in HIV-infected human monocytic cells . |
| 0.9491 | 1.0000 | 1.0000 | The present study demonstrates that triggering of complement receptors proteinCR1 ( CD35 ) and CR3 ( CD11b/CD18 ) enhances viral replication in HIV-infected human monocytic cells . |
| 0.9180 | 1.0000 | 1.0000 | The present study demonstrates that triggering of complement receptors CR1 ( CD35 ) and CR3 ( proteinCD11b/CD18 ) enhances viral replication in HIV-infected human monocytic cells . |
| 4.6792 | 20.9611 | 10.6090 | The present study demonstrates that triggering of complement receptors CR1 ( CD35 ) and CR3 ( CD11b/CD18 ) enhances viral replication in cell_typeHIV-infected human monocytic cells . |
| The present study demonstrates that triggering of complement receptors CR1 ( CD35 ) and CR3 ( CD11b/CD18 ) enhances viral replication in cell_lineHIV-infected human monocytic cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9869 | 10.6108 | 10.7354 | Monocytic cell lines and normal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of F(ab')2 fragments of proteinmonoclonal anti- CR1 or anti- CR3 Abs or with C3 fragments . |
| 2.2680 | 10.6580 | 10.2266 | Monocytic cell lines and normal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of F(ab')2 fragments of monoclonal anti- CR1 or proteinanti- CR3 Abs or with C3 fragments . |
| 2.1120 | 20.7275 | 0.9998 | Monocytic cell lines and normal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of proteinF(ab')2 fragments of monoclonal anti- CR1 or anti- CR3 Abs or with C3 fragments . |
| 1.4823 | 0.9955 | 10.0407 | cell_lineMonocytic cell lines and normal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of F(ab')2 fragments of monoclonal anti- CR1 or anti- CR3 Abs or with C3 fragments . |
| 1.3026 | 10.6378 | 0.9996 | Monocytic cell lines and normal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of F(ab')2 fragments of monoclonal anti- CR1 or anti- CR3 Abs or with proteinC3 fragments . |
| 0.8851 | 1.0000 | 0.9821 | Monocytic cell lines and normal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of F(ab')2 fragments of monoclonal anti- CR1 or anti- proteinCR3 Abs or with C3 fragments . |
| 0.8820 | 1.0000 | 1.0000 | Monocytic cell lines and normal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of F(ab')2 fragments of monoclonal anti- proteinCR1 or anti- CR3 Abs or with C3 fragments . |
| 3.9778 | 20.8725 | 10.8612 | Monocytic cell lines and cell_typenormal peripheral blood monocytes were infected with HIV-1 in vitro and cultured in the presence or absence of F(ab')2 fragments of monoclonal anti- CR1 or anti- CR3 Abs or with C3 fragments . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3862 | 20.0552 | 1.0000 | Stimulation of CR1 or CR3 induces a two- to fourfold increase in the amount of cell-associated and released proteinp24 Ag in cell cultures that was equivalent to that observed in control cultures triggered with LPS . |
| 1.6316 | 10.9877 | 1.0000 | Stimulation of proteinCR1 or CR3 induces a two- to fourfold increase in the amount of cell-associated and released p24 Ag in cell cultures that was equivalent to that observed in control cultures triggered with LPS . |
| 1.5684 | 10.2887 | 0.9993 | Stimulation of CR1 or CR3 induces a two- to fourfold increase in the amount of cell-associated and released p24 Ag in cell_linecell cultures that was equivalent to that observed in control cultures triggered with LPS . |
| 1.3702 | 10.6644 | 0.9999 | Stimulation of CR1 or CR3 induces a two- to fourfold increase in the amount of cell-associated and released p24 Ag in cell cultures that was equivalent to that observed in cell_linecontrol cultures triggered with LPS . |
| 0.8925 | 1.0000 | 1.0000 | Stimulation of CR1 or proteinCR3 induces a two- to fourfold increase in the amount of cell-associated and released p24 Ag in cell cultures that was equivalent to that observed in control cultures triggered with LPS . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1325 | 20.9483 | 0.9958 | We further observed that stimulation of CR1 or CR3 induces the nuclear translocation of proteinNF-kappa B p50/p65 in infected cells . |
| 1.5641 | 10.1639 | 0.9996 | We further observed that stimulation of CR1 or CR3 induces the nuclear translocation of NF-kappa B p50/p65 in cell_typeinfected cells . |
| 1.4320 | 10.8612 | 1.0000 | We further observed that stimulation of proteinCR1 or CR3 induces the nuclear translocation of NF-kappa B p50/p65 in infected cells . |
| 0.9816 | 1.0000 | 1.0000 | We further observed that stimulation of CR1 or CR3 induces the nuclear translocation of NF-kappa B proteinp50/p65 in infected cells . |
| 0.8442 | 0.9999 | 1.0000 | We further observed that stimulation of CR1 or proteinCR3 induces the nuclear translocation of NF-kappa B p50/p65 in infected cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8423 | 20.9127 | 10.5641 | Translocation of NF-kappa B p50/p65 was also observed following stimulation of CR1 or CR3 of cell_typeuninfected peripheral blood monocytes from HIV-seronegative donors . |
| 1.4284 | 10.6371 | 1.0000 | Translocation of NF-kappa B p50/p65 was also observed following stimulation of proteinCR1 or CR3 of uninfected peripheral blood monocytes from HIV-seronegative donors . |
| 0.8039 | 0.9986 | 1.0000 | Translocation of NF-kappa B p50/p65 was also observed following stimulation of CR1 or proteinCR3 of uninfected peripheral blood monocytes from HIV-seronegative donors . |
| 2.2040 | 20.9972 | 10.5615 | Translocation of proteinNF-kappa B p50/p65 was also observed following stimulation of CR1 or CR3 of uninfected peripheral blood monocytes from HIV-seronegative donors . |
| Translocation of NF-kappa B proteinp50/p65 was also observed following stimulation of CR1 or CR3 of uninfected peripheral blood monocytes from HIV-seronegative donors . | |||
| Translocation of proteinNF-kappa B p50/p65 was also observed following stimulation of CR1 or CR3 of uninfected peripheral blood monocytes from HIV-seronegative donors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6061 | 10.9362 | 1.0000 | The amount of protein translocated was similar to that observed when cells were stimulated with proteinrhTNF-alpha . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9934 | 20.4313 | 0.9999 | TNF-alpha did not mediate the translocation of NF-kappa B p50/p65 induced by triggering of proteincomplement receptors . |
| 1.7188 | 20.8611 | 0.8683 | TNF-alpha did not mediate the translocation of proteinNF-kappa B p50/p65 induced by triggering of complement receptors . |
| 0.9623 | 1.0000 | 1.0000 | proteinTNF-alpha did not mediate the translocation of NF-kappa B p50/p65 induced by triggering of complement receptors . |
| 2.2943 | 20.8430 | 1.0000 | TNF-alpha did not mediate the translocation of proteinNF-kappa B p50/p65 induced by triggering of complement receptors . |
| TNF-alpha did not mediate the translocation of NF-kappa B proteinp50/p65 induced by triggering of complement receptors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2683 | 20.5202 | 0.9999 | Taken together, these observations suggest that HIV gene expression may be activated in cell_typeinfected monocytes through interaction of the cells with complement-opsonized particles and that enhanced viral replication is associated with C3 receptor -mediated nuclear translocation of the NF-kappa B complex . |
| 2.2297 | 20.9123 | 0.9999 | Taken together, these observations suggest that HIV gene expression may be activated in infected monocytes through interaction of the cells with complement-opsonized particles and that enhanced viral replication is associated with C3 receptor -mediated nuclear translocation of the proteinNF-kappa B complex . |
| 1.5830 | 10.9952 | 1.0000 | Taken together, these observations suggest that HIV gene expression may be activated in infected monocytes through interaction of the cells with complement-opsonized particles and that enhanced viral replication is associated with proteinC3 receptor -mediated nuclear translocation of the NF-kappa B complex . |
| 2.8190 | 30.0654 | 0.8758 | Taken together, these observations suggest that HIV gene expression may be activated in infected monocytes through interaction of the cells with complement-opsonized particles and that enhanced viral replication is associated with C3 receptor -mediated nuclear translocation of the proteinNF-kappa B complex . |
| 0.8784 | 1.0000 | 1.0000 | Taken together, these observations suggest that HIV gene expression may be activated in infected cell_typemonocytes through interaction of the cells with complement-opsonized particles and that enhanced viral replication is associated with C3 receptor -mediated nuclear translocation of the NF-kappa B complex . |
| Taken together, these observations suggest that HIV gene expression may be activated in infected monocytes through interaction of the cells with proteincomplement-opsonized particles and that enhanced viral replication is associated with C3 receptor -mediated nuclear translocation of the NF-kappa B complex . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2998 | 20.2391 | 1.0000 | Attenuation of gamma interferon -induced tyrosine phosphorylation in cell_typemononuclear phagocytes infected with Leishmania donovani : selective inhibition of signaling through Janus kinases and Stat1 . |
| 2.2495 | 20.3747 | 1.0000 | Attenuation of proteingamma interferon -induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani : selective inhibition of signaling through Janus kinases and Stat1 . |
| 2.2018 | 20.9291 | 1.0000 | Attenuation of gamma interferon -induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani : selective inhibition of signaling through proteinJanus kinases and Stat1 . |
| 1.6571 | 10.3795 | 1.0000 | Attenuation of gamma interferon -induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani : selective inhibition of signaling through Janus kinases and proteinStat1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4792 | 20.0638 | 1.0000 | The induction of gene transcription in response to gamma interferon is impaired in cell_typemononuclear phagocytes infected with Leishmania donovani , and the mechanisms involved are not fully understood. |
| 2.4505 | 20.4933 | 1.0000 | The induction of gene transcription in response to proteingamma interferon is impaired in mononuclear phagocytes infected with Leishmania donovani , and the mechanisms involved are not fully understood. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9825 | 20.7808 | 10.7568 | The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of proteincellular protein tyrosine kinases , including the Janus kinases Jak1 and Jak2 , leading to tyrosine phosphorylation of the transcription factor Stat1 . |
| 2.1275 | 20.5035 | 0.9998 | The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases , including the proteinJanus kinases Jak1 and Jak2 , leading to tyrosine phosphorylation of the transcription factor Stat1 . |
| 1.4639 | 10.9722 | 1.0000 | The changes in gene expression brought about by proteingamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases , including the Janus kinases Jak1 and Jak2 , leading to tyrosine phosphorylation of the transcription factor Stat1 . |
| 0.9631 | 1.0000 | 1.0000 | The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases , including the Janus kinases Jak1 and proteinJak2 , leading to tyrosine phosphorylation of the transcription factor Stat1 . |
| 0.9585 | 1.0000 | 1.0000 | The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases , including the Janus kinases Jak1 and Jak2 , leading to tyrosine phosphorylation of the transcription factor proteinStat1 . |
| 0.9517 | 1.0000 | 1.0000 | The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases , including the Janus kinases proteinJak1 and Jak2 , leading to tyrosine phosphorylation of the transcription factor Stat1 . |
| 2.1092 | 20.9650 | 0.9995 | The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases , including the Janus kinases Jak1 and Jak2 , leading to tyrosine phosphorylation of the proteintranscription factor Stat1 . |
| 0.6846 | 0.9982 | 0.9999 | The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein proteintyrosine kinases , including the Janus kinases Jak1 and Jak2 , leading to tyrosine phosphorylation of the transcription factor Stat1 . |
| The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases , including the Janus kinases Jak1 and Jak2 , leading to tyrosine phosphorylation of the proteintranscription factor Stat1 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.4754 | 30.3772 | 20.7922 | To investigate the mechanisms accounting for the impaired responses to gamma interferon , a model system for examining overall changes in protein tyrosine phosphorylation , activation of Jak1 and Jak2 and phosphorylation of Stat1 was developed in cell_linephorbol 12-myristate 13-acetate -differentiated U-937 cells . |
| 2.0965 | 20.2732 | 1.0000 | To investigate the mechanisms accounting for the impaired responses to gamma interferon , a model system for examining overall changes in protein tyrosine phosphorylation , activation of Jak1 and Jak2 and phosphorylation of proteinStat1 was developed in phorbol 12-myristate 13-acetate -differentiated U-937 cells . |
| 2.0949 | 20.5571 | 1.0000 | To investigate the mechanisms accounting for the impaired responses to proteingamma interferon , a model system for examining overall changes in protein tyrosine phosphorylation , activation of Jak1 and Jak2 and phosphorylation of Stat1 was developed in phorbol 12-myristate 13-acetate -differentiated U-937 cells . |
| 1.5216 | 10.4264 | 1.0000 | To investigate the mechanisms accounting for the impaired responses to gamma interferon , a model system for examining overall changes in protein tyrosine phosphorylation , activation of proteinJak1 and Jak2 and phosphorylation of Stat1 was developed in phorbol 12-myristate 13-acetate -differentiated U-937 cells . |
| 0.9132 | 1.0000 | 1.0000 | To investigate the mechanisms accounting for the impaired responses to gamma interferon , a model system for examining overall changes in protein tyrosine phosphorylation , activation of Jak1 and proteinJak2 and phosphorylation of Stat1 was developed in phorbol 12-myristate 13-acetate -differentiated U-937 cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3437 | 20.0782 | 1.0000 | Analysis of whole-cell lysates by antiphosphotyrosine immunoblotting showed that incubation with proteingamma interferon brought about specific increases in phosphotyrosine labeling of several proteins. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6827 | 10.8227 | 0.9999 | Increased labeling of these proteins occurred to similar extents in cell_typecontrol cells and in cells that had been infected with L. donovani for 16 h. |
| 1.7519 | 10.4563 | 1.0000 | Increased labeling of these proteinproteins occurred to similar extents in control cells and in cells that had been infected with L. donovani for 16 h. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7479 | 10.3100 | 1.0000 | Jak1 , Jak2 , and proteinStat1 were immunoprecipitated from control and interferon-treated cells , and tyrosine phosphorylation of these proteins, detected by antiphosphotyrosine immunoblotting was used to measured their activation. |
| 1.5298 | 10.6802 | 0.9997 | Jak1 , Jak2 , and Stat1 were immunoprecipitated from control and cell_lineinterferon-treated cells , and tyrosine phosphorylation of these proteins, detected by antiphosphotyrosine immunoblotting was used to measured their activation. |
| 0.9813 | 1.0000 | 1.0000 | Jak1 , proteinJak2 , and Stat1 were immunoprecipitated from control and interferon-treated cells , and tyrosine phosphorylation of these proteins, detected by antiphosphotyrosine immunoblotting was used to measured their activation. |
| 0.9762 | 1.0000 | 1.0000 | proteinJak1 , Jak2 , and Stat1 were immunoprecipitated from control and interferon-treated cells , and tyrosine phosphorylation of these proteins, detected by antiphosphotyrosine immunoblotting was used to measured their activation. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2487 | 20.2048 | 0.9999 | Tyrosine phosphorylation of Jak1 , Jak2 , and Stat1 increased markedly, in a dose-dependent manner, in cell_lineU-937 cells incubated with gamma interferon . |
| 1.6188 | 10.8936 | 1.0000 | Tyrosine phosphorylation of Jak1 , Jak2 , and proteinStat1 increased markedly, in a dose-dependent manner, in U-937 cells incubated with gamma interferon . |
| 1.5213 | 10.9110 | 1.0000 | Tyrosine phosphorylation of proteinJak1 , Jak2 , and Stat1 increased markedly, in a dose-dependent manner, in U-937 cells incubated with gamma interferon . |
| 1.4327 | 10.7843 | 0.9999 | Tyrosine phosphorylation of Jak1 , Jak2 , and Stat1 increased markedly, in a dose-dependent manner, in U-937 cells incubated with proteingamma interferon . |
| 0.9204 | 1.0000 | 1.0000 | Tyrosine phosphorylation of Jak1 , proteinJak2 , and Stat1 increased markedly, in a dose-dependent manner, in U-937 cells incubated with gamma interferon . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6838 | 10.9321 | 1.0000 | In contrast, in cells infected with L. donovani , tyrosine phosphorylation of Jak1 , Jak2 , and proteinStat1 was markedly impaired. |
| 1.6355 | 10.7269 | 1.0000 | In contrast, in cells infected with L. donovani , tyrosine phosphorylation of proteinJak1 , Jak2 , and Stat1 was markedly impaired. |
| 0.9398 | 1.0000 | 1.0000 | In contrast, in cells infected with L. donovani , tyrosine phosphorylation of Jak1 , proteinJak2 , and Stat1 was markedly impaired. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7771 | 20.9882 | 10.8538 | Results similar to those observed with U-937 cells were also obtained with cell_typehuman peripheral blood monocytes . |
| 2.1042 | 20.5117 | 0.9999 | Results similar to those observed with cell_lineU-937 cells were also obtained with human peripheral blood monocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7056 | 20.7356 | 10.7229 | These findings indicate that infection of cell_typehuman mononuclear phagocytes with L. donovani leads to impaired gamma interferon -mediated tyrosine phosphorylation and selective effects on the Jak- Stat1 pathway . |
| 1.4880 | 10.5301 | 1.0000 | These findings indicate that infection of human mononuclear phagocytes with L. donovani leads to impaired proteingamma interferon -mediated tyrosine phosphorylation and selective effects on the Jak- Stat1 pathway . |
| 0.9714 | 1.0000 | 1.0000 | These findings indicate that infection of human mononuclear phagocytes with L. donovani leads to impaired gamma interferon -mediated tyrosine phosphorylation and selective effects on the Jak- proteinStat1 pathway . |
| 1.3243 | 10.8320 | 0.9996 | These findings indicate that infection of human mononuclear phagocytes with L. donovani leads to impaired gamma interferon -mediated tyrosine phosphorylation and selective effects on the proteinJak- Stat1 pathway . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1568 | 20.3286 | 0.9999 | Unresponsiveness to gamma interferon for activation of this pathway may explain impaired transcriptional responses in cell_typeleishmania-infected cells . |
| 2.1271 | 20.1407 | 1.0000 | Unresponsiveness to proteingamma interferon for activation of this pathway may explain impaired transcriptional responses in leishmania-infected cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.9999 | 20.7304 | 20.6266 | Mutually exclusive interaction of a novel proteinmatrix attachment region binding protein and the NF-muNR enhancer repressor . |
| 3.9537 | 30.5578 | 10.7874 | Mutually exclusive interaction of a novel matrix attachment region binding protein and the proteinNF-muNR enhancer repressor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.7614 | 10.5784 | 10.9647 | Implications for regulation of proteinimmunoglobulin heavy chain expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.2948 | 0.9978 | 10.1681 | The proteinimmunoglobulin heavy chain ( IgH ) intronic enhancer stimulates transcription from functional promoters in B lymphocytes but not other cell types. |
| 0.9403 | 1.0000 | 0.9944 | The immunoglobulin heavy chain ( proteinIgH ) intronic enhancer stimulates transcription from functional promoters in B lymphocytes but not other cell types. |
| 5.0649 | 10.9563 | 20.8118 | The DNAimmunoglobulin heavy chain ( IgH ) intronic enhancer stimulates transcription from functional promoters in B lymphocytes but not other cell types. |
| 1.1722 | 10.5166 | 0.9996 | The immunoglobulin heavy chain ( IgH ) intronic enhancer stimulates transcription from functional promoters in cell_typeB lymphocytes but not other cell types. |
| 1.1210 | 10.9718 | 0.9998 | The immunoglobulin heavy chain ( IgH ) intronic enhancer stimulates transcription from DNAfunctional promoters in B lymphocytes but not other cell types. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4201 | 10.2577 | 0.9999 | The observation that binding sites for the nuclear factor-mu negative regulator ( NF-muNR ) enhancer repressor overlap nuclear matrix attachment regions ( MARs ) in this enhancer has lead to the hypothesis that the cell type specificity of the DNAenhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). |
| 0.9576 | 1.0000 | 0.9916 | The observation that binding sites for the nuclear factor-mu negative regulator ( proteinNF-muNR ) enhancer repressor overlap nuclear matrix attachment regions ( MARs ) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). |
| 0.6248 | 1.0000 | 0.9999 | The observation that binding sites for the nuclear factor-mu negative regulator ( NF-muNR ) enhancer repressor overlap nuclear matrix attachment regions ( MARs ) in this DNAenhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). |
| 2.4567 | 20.1490 | 10.6710 | The observation that binding sites for the proteinnuclear factor-mu negative regulator ( NF-muNR ) enhancer repressor overlap nuclear matrix attachment regions ( MARs ) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). |
| 2.3625 | 10.2190 | 10.2173 | The observation that binding sites for the nuclear factor-mu negative regulator ( NF-muNR ) enhancer repressor overlap DNAnuclear matrix attachment regions ( MARs ) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). |
| 1.8335 | 20.6974 | 0.9990 | The observation that DNAbinding sites for the nuclear factor-mu negative regulator ( NF-muNR ) enhancer repressor overlap nuclear matrix attachment regions ( MARs ) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). |
| 0.9588 | 1.0000 | 1.0000 | The observation that binding sites for the nuclear factor-mu negative regulator ( NF-muNR ) enhancer repressor overlap nuclear matrix attachment regions ( DNAMARs ) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). |
| The observation that binding sites for the nuclear factor-mu negative regulator ( NF-muNR ) enhancer repressor overlap proteinnuclear matrix attachment regions ( MARs ) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). | |||
| The observation that binding sites for the proteinnuclear factor-mu negative regulator ( NF-muNR ) enhancer repressor overlap nuclear matrix attachment regions ( MARs ) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). | |||
| The observation that binding sites for the proteinnuclear factor-mu negative regulator ( NF-muNR ) enhancer repressor overlap nuclear matrix attachment regions ( MARs ) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). | |||
| The observation that binding sites for the nuclear factor-mu negative regulator ( NF-muNR ) enhancer repressor overlap nuclear matrix attachment regions ( proteinMARs ) in this enhancer has lead to the hypothesis that the cell type specificity of the enhancer might be controlled by regulating nuclear matrix attachment (Scheuermann, R. H., and Chen, U. (1989) Genes & Dev. 3, 1255-1266). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4278 | 20.6634 | 1.0000 | To understand the role of MARs in IgH enhancer regulation , we have identified a novel proteinMAR-binding protein , MAR-BP1 , from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the IgH enhancer . |
| 2.2852 | 20.5649 | 0.9999 | To understand the role of MARs in IgH enhancer regulation , we have identified a novel MAR-binding protein , MAR-BP1 , from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the DNAIgH enhancer . |
| 0.9579 | 1.0000 | 1.0000 | To understand the role of MARs in IgH enhancer regulation , we have identified a novel MAR-binding protein , proteinMAR-BP1 , from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the IgH enhancer . |
| 0.7919 | 0.9992 | 0.9999 | To understand the role of MARs in DNAIgH enhancer regulation , we have identified a novel MAR-binding protein , MAR-BP1 , from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the IgH enhancer . |
| 1.7260 | 10.3638 | 1.0000 | To understand the role of MARs in IgH enhancer regulation , we have identified a novel MAR-binding protein , MAR-BP1 , from soluble nuclear matrix preparations based on its ability to bind to the DNAMARs associated with the IgH enhancer . |
| 1.6438 | 10.5533 | 1.0000 | To understand the role of DNAMARs in IgH enhancer regulation , we have identified a novel MAR-binding protein , MAR-BP1 , from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the IgH enhancer . |
| To understand the role of MARs in IgH enhancer regulation , we have identified a novel MAR-binding protein , MAR-BP1 , from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the proteinIgH enhancer . | |||
| To understand the role of MARs in proteinIgH enhancer regulation , we have identified a novel MAR-binding protein , MAR-BP1 , from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the IgH enhancer . | |||
| To understand the role of proteinMARs in IgH enhancer regulation , we have identified a novel MAR-binding protein , MAR-BP1 , from soluble nuclear matrix preparations based on its ability to bind to the MARs associated with the IgH enhancer . | |||
| To understand the role of MARs in IgH enhancer regulation , we have identified a novel MAR-binding protein , MAR-BP1 , from soluble nuclear matrix preparations based on its ability to bind to the proteinMARs associated with the IgH enhancer . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7970 | 20.4047 | 10.5965 | Purified MAR-BP1 migrates as a 33-kDa protein , and it can be found in nuclear matrix preparations from a number of different types of cell_linelymphoid cell lines . |
| 2.2437 | 20.0575 | 1.0000 | Purified MAR-BP1 migrates as a protein33-kDa protein , and it can be found in nuclear matrix preparations from a number of different types of lymphoid cell lines . |
| 0.9843 | 1.0000 | 1.0000 | Purified proteinMAR-BP1 migrates as a 33-kDa protein , and it can be found in nuclear matrix preparations from a number of different types of lymphoid cell lines . |
| 0.7255 | 0.9981 | 1.0000 | proteinPurified MAR-BP1 migrates as a 33-kDa protein , and it can be found in nuclear matrix preparations from a number of different types of lymphoid cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6463 | 10.2015 | 1.0000 | Although specific binding sites have been difficult to localize by chemical or enzymatic footprinting procedures , NF-muNR binding sites are critical for efficient proteinMAR-BP1 binding . |
| 1.3964 | 10.7581 | 0.9964 | Although specific binding sites have been difficult to localize by chemical or enzymatic footprinting procedures , proteinNF-muNR binding sites are critical for efficient MAR-BP1 binding . |
| 3.1595 | 20.8103 | 10.6702 | Although specific binding sites have been difficult to localize by chemical or enzymatic footprinting procedures , DNANF-muNR binding sites are critical for efficient MAR-BP1 binding . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3105 | 20.4715 | 1.0000 | Indeed, binding of the DNAIgH enhancer to either intact nuclear matrix preparations or to MAR-BP1 is mutually exclusive to NF-muNR binding . |
| 1.6324 | 10.5368 | 1.0000 | Indeed, binding of the IgH enhancer to either intact nuclear matrix preparations or to proteinMAR-BP1 is mutually exclusive to NF-muNR binding . |
| 0.9098 | 1.0000 | 1.0000 | Indeed, binding of the IgH enhancer to either intact nuclear matrix preparations or to MAR-BP1 is mutually exclusive to proteinNF-muNR binding . |
| Indeed, binding of the proteinIgH enhancer to either intact nuclear matrix preparations or to MAR-BP1 is mutually exclusive to NF-muNR binding . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3125 | 20.2916 | 1.0000 | These results are consistent with a model for cell-type specific regulation in which binding of the proteinNF-muNR repressor to the IgH enhancer prevents nuclear matrix attachment in inappropriate cells by interfering with MAR-BP1 /enhancer interaction . |
| 2.2775 | 20.5983 | 0.9931 | These results are consistent with a model for cell-type specific regulation in which binding of the proteinNF-muNR repressor to the IgH enhancer prevents nuclear matrix attachment in inappropriate cells by interfering with MAR-BP1 /enhancer interaction . |
| 1.6438 | 10.0747 | 0.9999 | These results are consistent with a model for cell-type specific regulation in which binding of the NF-muNR repressor to the IgH enhancer prevents nuclear matrix attachment in inappropriate cells by interfering with proteinMAR-BP1 /enhancer interaction . |
| 1.5387 | 10.9752 | 1.0000 | These results are consistent with a model for cell-type specific regulation in which binding of the NF-muNR repressor to the DNAIgH enhancer prevents nuclear matrix attachment in inappropriate cells by interfering with MAR-BP1 /enhancer interaction . |
| 0.4792 | 1.0000 | 0.9996 | These results are consistent with a model for cell-type specific regulation in which binding of the NF-muNR repressor to the IgH enhancer prevents nuclear matrix attachment in inappropriate cells by interfering with MAR-BP1 DNA/enhancer interaction . |
| 1.6245 | 10.6559 | 0.9999 | These results are consistent with a model for cell-type specific regulation in which binding of the NF-muNR repressor to the IgH enhancer prevents nuclear matrix attachment in cell_typeinappropriate cells by interfering with MAR-BP1 /enhancer interaction . |
| These results are consistent with a model for cell-type specific regulation in which binding of the NF-muNR repressor to the proteinIgH enhancer prevents nuclear matrix attachment in inappropriate cells by interfering with MAR-BP1 /enhancer interaction . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.7639 | 30.6715 | 10.3658 | PU.1 ( Spi-1 ) and C/EBP alpha regulate expression of the DNAgranulocyte-macrophage colony-stimulating factor receptor alpha gene . |
| 1.1533 | 10.5214 | 1.0000 | PU.1 ( Spi-1 ) and proteinC/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene . |
| 0.9621 | 1.0000 | 1.0000 | PU.1 ( proteinSpi-1 ) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene . |
| 0.9477 | 1.0000 | 1.0000 | proteinPU.1 ( Spi-1 ) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene . |
| 2.4398 | 20.9571 | 10.3997 | PU.1 ( Spi-1 ) and C/EBP alpha regulate expression of the proteingranulocyte-macrophage colony-stimulating factor receptor alpha gene . |
| PU.1 ( Spi-1 ) and C/EBP alpha regulate expression of the proteingranulocyte-macrophage colony-stimulating factor receptor alpha gene . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6167 | 0.9985 | 10.6846 | proteinGrowth factor receptors play an important role in hematopoiesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4912 | 40.7452 | 10.0588 | In order to further understand the mechanisms directing the expression of these key regulators of hematopoiesis , we initiated a study investigating the transcription factors activating the expression of the proteingranulocyte-macrophage colony-stimulating factor ( GM-CSF ) receptor alpha gene . |
| 1.1380 | 30.1405 | 0.9999 | In order to further understand the mechanisms directing the expression of these key regulators of hematopoiesis , we initiated a study investigating the proteintranscription factors activating the expression of the granulocyte-macrophage colony-stimulating factor ( GM-CSF ) receptor alpha gene . |
| 0.9537 | 1.0000 | 0.9974 | In order to further understand the mechanisms directing the expression of these key regulators of hematopoiesis , we initiated a study investigating the transcription factors activating the expression of the granulocyte-macrophage colony-stimulating factor ( proteinGM-CSF ) receptor alpha gene . |
| 0.8283 | 0.8203 | 0.9140 | In order to further understand the mechanisms directing the expression of these key regulators of hematopoiesis , we initiated a study investigating the transcription factors activating the expression of the DNAgranulocyte-macrophage colony-stimulating factor ( GM-CSF ) receptor alpha gene . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.6513 | 30.7659 | 20.6696 | Here, we demonstrate that the DNAhuman GM-CSF receptor alpha promoter directs reporter gene activity in a tissue-specific fashion in myelomonocytic cells , which correlates with its expression pattern as analyzed by reverse transcription PCR . |
| 1.9491 | 20.1137 | 0.9998 | Here, we demonstrate that the human GM-CSF receptor alpha promoter directs reporter gene activity in a tissue-specific fashion in cell_typemyelomonocytic cells , which correlates with its expression pattern as analyzed by reverse transcription PCR . |
| 0.9197 | 1.0000 | 0.9970 | Here, we demonstrate that the human proteinGM-CSF receptor alpha promoter directs reporter gene activity in a tissue-specific fashion in myelomonocytic cells , which correlates with its expression pattern as analyzed by reverse transcription PCR . |
| Here, we demonstrate that the human GM-CSF receptor alpha promoter directs DNAreporter gene activity in a tissue-specific fashion in myelomonocytic cells , which correlates with its expression pattern as analyzed by reverse transcription PCR . | |||
| Here, we demonstrate that the human proteinGM-CSF receptor alpha promoter directs reporter gene activity in a tissue-specific fashion in myelomonocytic cells , which correlates with its expression pattern as analyzed by reverse transcription PCR . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2993 | 10.8695 | 10.8067 | The DNAGM-CSF receptor alpha promoter contains an important functional site between positions -53 and -41 as identified by deletion analysis of reporter constructs . |
| 1.3249 | 10.9682 | 0.9998 | The GM-CSF receptor alpha promoter contains an important functional site between positions -53 and -41 as identified by deletion analysis of DNAreporter constructs . |
| 0.7469 | 1.0000 | 0.9964 | The proteinGM-CSF receptor alpha promoter contains an important functional site between positions -53 and -41 as identified by deletion analysis of reporter constructs . |
| 0.5677 | 0.9979 | 10.5777 | The proteinGM-CSF receptor alpha promoter contains an important functional site between positions -53 and -41 as identified by deletion analysis of reporter constructs . |
| 3.4849 | 20.2775 | 10.8279 | The GM-CSF receptor alpha promoter contains an important functional site between DNApositions -53 and -41 as identified by deletion analysis of reporter constructs . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9315 | 0.9997 | 0.9999 | We show that the myeloid and B cell transcription factor proteinPU.1 binds specifically to this site. |
| 6.3153 | 30.5808 | 10.8603 | We show that the proteinmyeloid and B cell transcription factor PU.1 binds specifically to this site. |
| 0.5990 | 0.9562 | 0.9996 | We show that the myeloid and B cell proteintranscription factor PU.1 binds specifically to this site. |
| We show that the myeloid and proteinB cell transcription factor PU.1 binds specifically to this site. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4620 | 20.7380 | 10.9954 | Furthermore, we demonstrate that a CCAAT site located upstream of the PU.1 site between positions -70 and -54 is involved in positive-negative regulation of the proteinGM-CSF receptor alpha promoter activity . |
| 2.2153 | 20.1100 | 0.9968 | Furthermore, we demonstrate that a CCAAT site located upstream of the PU.1 site between positions -70 and -54 is involved in positive-negative regulation of the proteinGM-CSF receptor alpha promoter activity . |
| 2.0955 | 20.0814 | 1.0000 | Furthermore, we demonstrate that a CCAAT site located upstream of the DNAPU.1 site between positions -70 and -54 is involved in positive-negative regulation of the GM-CSF receptor alpha promoter activity . |
| 2.0955 | 20.1109 | 0.9999 | Furthermore, we demonstrate that a DNACCAAT site located upstream of the PU.1 site between positions -70 and -54 is involved in positive-negative regulation of the GM-CSF receptor alpha promoter activity . |
| 2.0515 | 20.0661 | 0.9947 | Furthermore, we demonstrate that a CCAAT site located upstream of the proteinPU.1 site between positions -70 and -54 is involved in positive-negative regulation of the GM-CSF receptor alpha promoter activity . |
| 2.9266 | 10.8897 | 10.6532 | Furthermore, we demonstrate that a CCAAT site located upstream of the PU.1 site between positions DNA-70 and -54 is involved in positive-negative regulation of the GM-CSF receptor alpha promoter activity . |
| Furthermore, we demonstrate that a CCAAT site located upstream of the PU.1 site between positions -70 and -54 is involved in positive-negative regulation of the DNAGM-CSF receptor alpha promoter activity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4912 | 20.2909 | 10.6733 | C/EBP alpha is the major proteinCCAAT/enhancer -binding protein ( C/EBP ) form binding to this site in nuclear extracts of U937 cells . |
| 2.2266 | 20.4234 | 0.9999 | C/EBP alpha is the major CCAAT/enhancer -binding protein ( C/EBP ) form binding to this site in nuclear extracts of cell_lineU937 cells . |
| 0.9080 | 1.0000 | 1.0000 | proteinC/EBP alpha is the major CCAAT/enhancer -binding protein ( C/EBP ) form binding to this site in nuclear extracts of U937 cells . |
| 0.7997 | 1.0000 | 0.9987 | C/EBP alpha is the major CCAAT/enhancer -binding protein ( proteinC/EBP ) form binding to this site in nuclear extracts of U937 cells . |
| 1.4375 | 10.5747 | 0.9997 | C/EBP alpha is the major CCAAT/enhancer -binding protein ( proteinC/EBP ) form binding to this site in nuclear extracts of U937 cells . |
| C/EBP alpha is the major DNACCAAT/enhancer -binding protein ( C/EBP ) form binding to this site in nuclear extracts of U937 cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5015 | 20.7311 | 10.8702 | Point mutations of either the PU.1 site or the C/EBP site that abolish the binding of the respective factors result in a significant decrease of proteinGM-CSF receptor alpha promoter activity in myelomonocytic cells only. |
| 2.1907 | 20.6894 | 0.9998 | Point mutations of either the PU.1 site or the C/EBP site that abolish the binding of the respective factors result in a significant decrease of DNAGM-CSF receptor alpha promoter activity in myelomonocytic cells only. |
| 1.9865 | 20.2238 | 0.9993 | Point mutations of either the PU.1 site or the C/EBP site that abolish the binding of the respective factors result in a significant decrease of GM-CSF receptor alpha promoter activity in cell_typemyelomonocytic cells only. |
| 1.4093 | 10.9541 | 0.9999 | Point mutations of either the DNAPU.1 site or the C/EBP site that abolish the binding of the respective factors result in a significant decrease of GM-CSF receptor alpha promoter activity in myelomonocytic cells only. |
| 1.3669 | 10.9967 | 0.9998 | Point mutations of either the PU.1 site or the DNAC/EBP site that abolish the binding of the respective factors result in a significant decrease of GM-CSF receptor alpha promoter activity in myelomonocytic cells only. |
| 0.7745 | 1.0000 | 0.9977 | Point mutations of either the PU.1 site or the C/EBP site that abolish the binding of the respective factors result in a significant decrease of proteinGM-CSF receptor alpha promoter activity in myelomonocytic cells only. |
| Point mutations of either the proteinPU.1 site or the C/EBP site that abolish the binding of the respective factors result in a significant decrease of GM-CSF receptor alpha promoter activity in myelomonocytic cells only. | |||
| Point mutations of either the PU.1 site or the proteinC/EBP site that abolish the binding of the respective factors result in a significant decrease of GM-CSF receptor alpha promoter activity in myelomonocytic cells only. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4042 | 20.5605 | 10.5063 | Furthermore, we demonstrate that in myeloid and B cell extracts , PU.1 forms a novel, specific, more slowly migrating complex ( PU-SF ) when binding the DNAGM-CSF receptor alpha promoter PU.1 site . |
| 1.4752 | 20.5590 | 10.4118 | Furthermore, we demonstrate that in myeloid and B cell extracts , PU.1 forms a novel, specific, more slowly migrating complex ( PU-SF ) when binding the proteinGM-CSF receptor alpha promoter PU.1 site . |
| 0.9621 | 1.0000 | 1.0000 | Furthermore, we demonstrate that in myeloid and B cell extracts , PU.1 forms a novel, specific, more slowly migrating complex ( proteinPU-SF ) when binding the GM-CSF receptor alpha promoter PU.1 site . |
| 0.9551 | 0.9999 | 0.9389 | Furthermore, we demonstrate that in myeloid and B cell extracts , PU.1 forms a novel, specific, more slowly migrating complex ( PU-SF ) when binding the GM-CSF receptor alpha promoter proteinPU.1 site . |
| 0.8684 | 1.0000 | 1.0000 | Furthermore, we demonstrate that in myeloid and B cell extracts , proteinPU.1 forms a novel, specific, more slowly migrating complex ( PU-SF ) when binding the GM-CSF receptor alpha promoter PU.1 site . |
| 0.7852 | 0.9659 | 0.9994 | Furthermore, we demonstrate that in myeloid and B cell extracts , PU.1 forms a novel, specific, more slowly migrating complex ( PU-SF ) when binding the GM-CSF receptor alpha promoter DNAPU.1 site . |
| 0.6377 | 1.0000 | 0.9945 | Furthermore, we demonstrate that in myeloid and B cell extracts , PU.1 forms a novel, specific, more slowly migrating complex ( PU-SF ) when binding the proteinGM-CSF receptor alpha promoter PU.1 site . |
| 4.5246 | 20.5094 | 10.8872 | Furthermore, we demonstrate that in myeloid and B cell extracts , PU.1 forms a novel, specific, more proteinslowly migrating complex ( PU-SF ) when binding the GM-CSF receptor alpha promoter PU.1 site . |
| 4.2680 | 20.4712 | 10.7649 | Furthermore, we demonstrate that in myeloid and B cell extracts , PU.1 forms a novel, specific, more slowly migrating complex ( PU-SF ) when binding the DNAGM-CSF receptor alpha promoter PU.1 site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6490 | 20.6656 | 10.8942 | This is the first demonstration of a specific interaction with PU.1 on a DNAmyeloid PU.1 binding site . |
| 1.3044 | 10.8926 | 1.0000 | This is the first demonstration of a specific interaction with proteinPU.1 on a myeloid PU.1 binding site . |
| 0.8880 | 1.0000 | 0.9943 | This is the first demonstration of a specific interaction with PU.1 on a myeloid proteinPU.1 binding site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3334 | 20.8054 | 10.9362 | The novel complex is distinct from that described previously as binding to B cell enhancer sites and can be formed by addition of PU.1 to extracts from certain cell_typenonmyeloid cell types which do not express PU.1 , including T cells and epithelial cells , but not from erythroid cells . |
| 4.0469 | 20.8599 | 10.5486 | The novel complex is distinct from that described previously as binding to DNAB cell enhancer sites and can be formed by addition of PU.1 to extracts from certain nonmyeloid cell types which do not express PU.1 , including T cells and epithelial cells , but not from erythroid cells . |
| 2.2006 | 20.4228 | 0.9998 | The novel complex is distinct from that described previously as binding to B cell enhancer sites and can be formed by addition of PU.1 to extracts from certain nonmyeloid cell types which do not express PU.1 , including T cells and epithelial cells , but not from cell_typeerythroid cells . |
| 1.6702 | 10.0324 | 1.0000 | The novel complex is distinct from that described previously as binding to B cell enhancer sites and can be formed by addition of PU.1 to extracts from certain nonmyeloid cell types which do not express proteinPU.1 , including T cells and epithelial cells , but not from erythroid cells . |
| 1.6603 | 10.1799 | 1.0000 | The novel complex is distinct from that described previously as binding to B cell enhancer sites and can be formed by addition of proteinPU.1 to extracts from certain nonmyeloid cell types which do not express PU.1 , including T cells and epithelial cells , but not from erythroid cells . |
| 1.5655 | 10.7862 | 0.9999 | The novel complex is distinct from that described previously as binding to B cell enhancer sites and can be formed by addition of PU.1 to extracts from certain nonmyeloid cell types which do not express PU.1 , including T cells and cell_typeepithelial cells , but not from erythroid cells . |
| 1.5198 | 10.9067 | 0.9999 | The novel complex is distinct from that described previously as binding to B cell enhancer sites and can be formed by addition of PU.1 to extracts from certain nonmyeloid cell types which do not express PU.1 , including cell_typeT cells and epithelial cells , but not from erythroid cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2402 | 20.5235 | 0.9999 | Furthermore, we demonstrate that the proteinPU-SF complex binds to PU.1 sites found on a number of myeloid promoters , and its formation requires an intact PU.1 site adjacent to a single-stranded region. |
| 2.1655 | 20.2695 | 1.0000 | Furthermore, we demonstrate that the PU-SF complex binds to PU.1 sites found on a number of myeloid promoters , and its formation requires an intact DNAPU.1 site adjacent to a single-stranded region. |
| 2.1087 | 20.0512 | 0.9999 | Furthermore, we demonstrate that the PU-SF complex binds to PU.1 sites found on a number of DNAmyeloid promoters , and its formation requires an intact PU.1 site adjacent to a single-stranded region. |
| 2.0602 | 20.0445 | 0.9902 | Furthermore, we demonstrate that the PU-SF complex binds to PU.1 sites found on a number of myeloid promoters , and its formation requires an intact proteinPU.1 site adjacent to a single-stranded region. |
| 1.6020 | 20.5005 | 0.9727 | Furthermore, we demonstrate that the proteinPU-SF complex binds to PU.1 sites found on a number of myeloid promoters , and its formation requires an intact PU.1 site adjacent to a single-stranded region. |
| 1.5183 | 10.8961 | 0.9940 | Furthermore, we demonstrate that the PU-SF complex binds to proteinPU.1 sites found on a number of myeloid promoters , and its formation requires an intact PU.1 site adjacent to a single-stranded region. |
| 2.2345 | 20.0170 | 1.0000 | Furthermore, we demonstrate that the PU-SF complex binds to DNAPU.1 sites found on a number of myeloid promoters , and its formation requires an intact PU.1 site adjacent to a single-stranded region. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9860 | 20.7186 | 10.1118 | Expression of PU.1 in nonmyeloid cells can activate the DNAGM-CSF receptor alpha promoter . |
| 2.0402 | 20.1836 | 0.9962 | Expression of PU.1 in nonmyeloid cells can activate the proteinGM-CSF receptor alpha promoter . |
| 1.2922 | 10.9737 | 1.0000 | Expression of proteinPU.1 in nonmyeloid cells can activate the GM-CSF receptor alpha promoter . |
| 1.2743 | 10.7631 | 0.9997 | Expression of PU.1 in cell_typenonmyeloid cells can activate the GM-CSF receptor alpha promoter . |
| 2.2520 | 20.4517 | 10.8480 | Expression of PU.1 in nonmyeloid cells can activate the proteinGM-CSF receptor alpha promoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9561 | 20.8669 | 10.6937 | Deletion of the amino-terminal region of PU.1 results in a failure to form the PU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the PU-SF complex is of functional importance for the activity of the DNAGM-CSF receptor alpha promoter . |
| 2.2571 | 20.4164 | 1.0000 | Deletion of the amino-terminal region of PU.1 results in a failure to form the PU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the proteinPU-SF complex is of functional importance for the activity of the GM-CSF receptor alpha promoter . |
| 2.1507 | 20.5913 | 1.0000 | Deletion of the proteinamino-terminal region of PU.1 results in a failure to form the PU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the PU-SF complex is of functional importance for the activity of the GM-CSF receptor alpha promoter . |
| 1.7307 | 20.9040 | 0.9850 | Deletion of the amino-terminal region of PU.1 results in a failure to form the PU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the proteinPU-SF complex is of functional importance for the activity of the GM-CSF receptor alpha promoter . |
| 1.4981 | 10.0782 | 0.9978 | Deletion of the amino-terminal region of PU.1 results in a failure to form the PU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the PU-SF complex is of functional importance for the activity of the proteinGM-CSF receptor alpha promoter . |
| 0.8762 | 1.0000 | 1.0000 | Deletion of the amino-terminal region of proteinPU.1 results in a failure to form the PU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the PU-SF complex is of functional importance for the activity of the GM-CSF receptor alpha promoter . |
| 2.2962 | 20.1235 | 1.0000 | Deletion of the amino-terminal region of PU.1 results in a failure to form the proteinPU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the PU-SF complex is of functional importance for the activity of the GM-CSF receptor alpha promoter . |
| Deletion of the amino-terminal region of PU.1 results in a failure to form the proteinPU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the PU-SF complex is of functional importance for the activity of the GM-CSF receptor alpha promoter . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4330 | 10.8739 | 10.4353 | Finally, we demonstrate that C/EBP alpha can also active the DNAGM-CSF receptor alpha promoter in nonmyeloid cells . |
| 1.4377 | 10.1052 | 0.9994 | Finally, we demonstrate that C/EBP alpha can also active the GM-CSF receptor alpha promoter in cell_typenonmyeloid cells . |
| 1.3822 | 10.4029 | 0.9999 | Finally, we demonstrate that proteinC/EBP alpha can also active the GM-CSF receptor alpha promoter in nonmyeloid cells . |
| 0.6899 | 1.0000 | 0.9977 | Finally, we demonstrate that C/EBP alpha can also active the proteinGM-CSF receptor alpha promoter in nonmyeloid cells . |
| Finally, we demonstrate that proteinC/EBP alpha can also active the GM-CSF receptor alpha promoter in nonmyeloid cells . | |||
| Finally, we demonstrate that C/EBP alpha can also active the proteinGM-CSF receptor alpha promoter in nonmyeloid cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4770 | 10.6439 | 1.0000 | HMG-I binds to DNAGATA motifs : implications for an HPFH syndrome . |
| 0.9690 | 1.0000 | 1.0000 | proteinHMG-I binds to GATA motifs : implications for an HPFH syndrome . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4520 | 20.2876 | 10.5573 | We have examined binding of the nuclear protein HMG-I to the DNAhuman gamma-globin promoter . |
| 1.6463 | 20.3886 | 0.9841 | We have examined binding of the proteinnuclear protein HMG-I to the human gamma-globin promoter . |
| 0.9852 | 1.0000 | 1.0000 | We have examined binding of the nuclear protein proteinHMG-I to the human gamma-globin promoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8490 | 30.4582 | 10.7462 | We find that HMG-I binds preferentially to the more 3' of a pair of GATA motifs in the gamma-globin promoter ; this paired motif is bound by the proteinerythroid factor GATA-1 . |
| 2.1494 | 20.7070 | 0.9999 | We find that HMG-I binds preferentially to the more 3' of a pair of DNAGATA motifs in the gamma-globin promoter ; this paired motif is bound by the erythroid factor GATA-1 . |
| 2.1231 | 20.1361 | 0.9999 | We find that HMG-I binds preferentially to the more 3' of a pair of GATA motifs in the DNAgamma-globin promoter ; this paired motif is bound by the erythroid factor GATA-1 . |
| 1.7438 | 10.0494 | 1.0000 | We find that proteinHMG-I binds preferentially to the more 3' of a pair of GATA motifs in the gamma-globin promoter ; this paired motif is bound by the erythroid factor GATA-1 . |
| 0.9522 | 1.0000 | 1.0000 | We find that HMG-I binds preferentially to the more 3' of a pair of GATA motifs in the gamma-globin promoter ; this paired motif is bound by the erythroid factor proteinGATA-1 . |
| 2.0759 | 20.2015 | 0.9999 | We find that HMG-I binds preferentially to the more 3' of a pair of GATA motifs in the gamma-globin promoter ; this DNApaired motif is bound by the erythroid factor GATA-1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9014 | 20.7497 | 10.4402 | A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in cell_typeadult red blood cells ( HPFH ) and up-regulation of the gamma-globin promoter in in vitro expression assays ; HMG-I does not bind to this mutant sequence . |
| 2.2196 | 20.6383 | 0.9999 | A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells ( HPFH ) and up-regulation of the gamma-globin promoter in in vitro expression assays ; HMG-I does not bind to this DNAmutant sequence . |
| 2.1922 | 20.6688 | 1.0000 | A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells ( HPFH ) and up-regulation of the DNAgamma-globin promoter in in vitro expression assays ; HMG-I does not bind to this mutant sequence . |
| 1.6620 | 10.1948 | 1.0000 | A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of proteingamma-globin in adult red blood cells ( HPFH ) and up-regulation of the gamma-globin promoter in in vitro expression assays ; HMG-I does not bind to this mutant sequence . |
| 0.9371 | 1.0000 | 1.0000 | A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells ( cell_typeHPFH ) and up-regulation of the gamma-globin promoter in in vitro expression assays ; HMG-I does not bind to this mutant sequence . |
| 0.8822 | 1.0000 | 1.0000 | A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells ( HPFH ) and up-regulation of the gamma-globin promoter in in vitro expression assays ; proteinHMG-I does not bind to this mutant sequence . |
| 0.8316 | 1.0000 | 1.0000 | A naturally occurring mutation (-175 T-C) in the area bound by proteinHMG-I results in overexpression of gamma-globin in adult red blood cells ( HPFH ) and up-regulation of the gamma-globin promoter in in vitro expression assays ; HMG-I does not bind to this mutant sequence . |
| A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells ( HPFH ) and up-regulation of the proteingamma-globin promoter in in vitro expression assays ; HMG-I does not bind to this mutant sequence . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1028 | 20.1677 | 1.0000 | A survey of DNAGATA motifs from other globin cis-elements demonstrates HMG-I binding to most of them. |
| 1.4410 | 10.9345 | 0.9999 | A survey of GATA motifs from other DNAglobin cis-elements demonstrates HMG-I binding to most of them. |
| 0.9189 | 1.0000 | 1.0000 | A survey of GATA motifs from other globin cis-elements demonstrates proteinHMG-I binding to most of them. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3546 | 20.3693 | 1.0000 | These findings implicate HMG-I in the HPFH phenotype ; we speculate that it may participate in the formation of proteinmultiprotein complexes that regulate globin gene expression . |
| 1.7634 | 10.5016 | 1.0000 | These findings implicate proteinHMG-I in the HPFH phenotype ; we speculate that it may participate in the formation of multiprotein complexes that regulate globin gene expression . |
| 2.3566 | 20.0540 | 0.9997 | These findings implicate HMG-I in the HPFH phenotype ; we speculate that it may participate in the formation of multiprotein complexes that regulate DNAglobin gene expression . |
| These findings implicate HMG-I in the cell_typeHPFH phenotype ; we speculate that it may participate in the formation of multiprotein complexes that regulate globin gene expression . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1793 | 30.6902 | 10.6695 | Constitutive activation of different proteinJak tyrosine kinases in human T cell leukemia virus type 1 ( HTLV-1 ) tax protein or virus-transformed cells . |
| 1.8723 | 20.8938 | 0.9991 | Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 ( HTLV-1 ) tax protein or cell_linevirus-transformed cells . |
| 1.6561 | 0.9370 | 20.2882 | Constitutive activation of different Jak tyrosine kinases in proteinhuman T cell leukemia virus type 1 ( HTLV-1 ) tax protein or virus-transformed cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0156 | 10.9205 | 10.7559 | The proteinviral encoded protein tax , is thought to play an important role in oncogenesis . |
| 0.9811 | 1.0000 | 1.0000 | The viral encoded protein proteintax , is thought to play an important role in oncogenesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7494 | 10.4389 | 1.0000 | Our previous data obtained from a tax transgenic mouse model revealed that tax transforms mouse fibroblasts but not cell_typethymocytes , despite comparable levels of tax expression in both tissues. |
| 1.7360 | 10.0484 | 1.0000 | Our previous data obtained from a tax transgenic mouse model revealed that proteintax transforms mouse fibroblasts but not thymocytes , despite comparable levels of tax expression in both tissues. |
| 1.6787 | 10.4494 | 1.0000 | Our previous data obtained from a tax transgenic mouse model revealed that tax transforms mouse fibroblasts but not thymocytes , despite comparable levels of proteintax expression in both tissues. |
| 1.6266 | 10.2960 | 1.0000 | Our previous data obtained from a proteintax transgenic mouse model revealed that tax transforms mouse fibroblasts but not thymocytes , despite comparable levels of tax expression in both tissues. |
| 1.5578 | 10.5678 | 0.9999 | Our previous data obtained from a tax transgenic mouse model revealed that tax transforms cell_typemouse fibroblasts but not thymocytes , despite comparable levels of tax expression in both tissues. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.2676 | 30.4707 | 20.3635 | Constitutive tyrosine phosphorylation of a 130-kD protein (s) was observed in the tax transformed fibroblast B line and in cell_lineHTLV-1 transformed human lymphoid lines , but not in thymocytes from Thy-tax transgenic mice . |
| 1.9327 | 20.9141 | 1.0000 | Constitutive tyrosine phosphorylation of a protein130-kD protein (s) was observed in the tax transformed fibroblast B line and in HTLV-1 transformed human lymphoid lines , but not in thymocytes from Thy-tax transgenic mice . |
| 1.5632 | 10.1191 | 1.0000 | Constitutive tyrosine phosphorylation of a 130-kD protein (s) was observed in the tax transformed fibroblast B line and in HTLV-1 transformed human lymphoid lines , but not in cell_typethymocytes from Thy-tax transgenic mice . |
| 5.4078 | 20.9456 | 20.9862 | Constitutive tyrosine phosphorylation of a 130-kD protein (s) was observed in the cell_linetax transformed fibroblast B line and in HTLV-1 transformed human lymphoid lines , but not in thymocytes from Thy-tax transgenic mice . |
| Constitutive tyrosine phosphorylation of a 130-kD protein (s) was observed in the proteintax transformed fibroblast B line and in HTLV-1 transformed human lymphoid lines , but not in thymocytes from Thy-tax transgenic mice . | |||
| Constitutive tyrosine phosphorylation of a 130-kD protein (s) was observed in the tax cell_linetransformed fibroblast B line and in HTLV-1 transformed human lymphoid lines , but not in thymocytes from Thy-tax transgenic mice . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 7.0562 | 40.6808 | 20.5174 | Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of Jak kinase specific antibodies , identified p130 as Jak2 in the tax transformed mouse fibroblastic cell line and Jak3 in cell_lineHTLV-1 transformed human T cell lines . |
| 5.0047 | 30.3447 | 10.4925 | Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of proteinJak kinase specific antibodies , identified p130 as Jak2 in the tax transformed mouse fibroblastic cell line and Jak3 in HTLV-1 transformed human T cell lines . |
| 0.8596 | 0.9999 | 1.0000 | Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of Jak kinase specific antibodies , identified p130 as proteinJak2 in the tax transformed mouse fibroblastic cell line and Jak3 in HTLV-1 transformed human T cell lines . |
| 0.8488 | 0.9997 | 1.0000 | Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of Jak kinase specific antibodies , identified p130 as Jak2 in the tax transformed mouse fibroblastic cell line and proteinJak3 in HTLV-1 transformed human T cell lines . |
| 7.7758 | 30.9470 | 20.7674 | Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of Jak kinase specific antibodies , identified p130 as Jak2 in the cell_linetax transformed mouse fibroblastic cell line and Jak3 in HTLV-1 transformed human T cell lines . |
| 0.8714 | 1.0000 | 1.0000 | Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of Jak kinase specific antibodies , identified proteinp130 as Jak2 in the tax transformed mouse fibroblastic cell line and Jak3 in HTLV-1 transformed human T cell lines . |
| Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of Jak kinase specific antibodies , identified p130 as Jak2 in the tax transformed cell_linemouse fibroblastic cell line and Jak3 in HTLV-1 transformed human T cell lines . | |||
| Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of proteinJak kinase specific antibodies , identified p130 as Jak2 in the tax transformed mouse fibroblastic cell line and Jak3 in HTLV-1 transformed human T cell lines . | |||
| Phosphotyrosine immunoprecipitation followed by Western blot analysis with a set of Jak kinase specific antibodies , identified p130 as Jak2 in the proteintax transformed mouse fibroblastic cell line and Jak3 in HTLV-1 transformed human T cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9299 | 10.7911 | 10.9690 | Phosphorylation of Jak2 in cell_linetax transformed cells resulted from high expression of IL-6 . |
| 1.3401 | 10.8170 | 1.0000 | Phosphorylation of Jak2 in tax transformed cells resulted from high expression of proteinIL-6 . |
| 1.2927 | 10.7931 | 1.0000 | Phosphorylation of proteinJak2 in tax transformed cells resulted from high expression of IL-6 . |
| Phosphorylation of Jak2 in proteintax transformed cells resulted from high expression of IL-6 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5067 | 20.0544 | 0.9999 | Tyrosine phosphorylation of this protein could also be induced in Balb/c3T3 cells using a supernatant from the cell_lineB line , which was associated with induction of cell proliferation . |
| 2.4561 | 20.6760 | 1.0000 | Tyrosine phosphorylation of this protein could also be induced in cell_lineBalb/c3T3 cells using a supernatant from the B line , which was associated with induction of cell proliferation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.7752 | 20.0276 | 10.7567 | Both phosphorylation and proliferation were inhibited by proteinIL-6 neutralizing antibodies . |
| 1.3265 | 10.4001 | 0.9957 | Both phosphorylation and proliferation were inhibited by proteinIL-6 neutralizing antibodies . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.4270 | 30.4610 | 20.0919 | Constitutive phosphorylation of Jak kinases may facilitate tumor growth in both cell_typeHTLV-1 infected human T cells and the transgenic mouse model . |
| 1.2288 | 20.3922 | 1.0000 | Constitutive phosphorylation of proteinJak kinases may facilitate tumor growth in both HTLV-1 infected human T cells and the transgenic mouse model . |
| Constitutive phosphorylation of Jak kinases may facilitate tumor growth in both HTLV-1 infected human cell_typeT cells and the transgenic mouse model . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9750 | 20.5186 | 10.9307 | Regulation of c-jun mRNA expression by hydroxyurea in cell_linehuman K562 cells during erythroid differentiation [published erratum appears in Biochim Biophys Acta 1995 Dec 27;1264(3):409] |
| 2.4792 | 20.4352 | 0.9999 | Regulation of RNAc-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation [published erratum appears in Biochim Biophys Acta 1995 Dec 27;1264(3):409] |
| Regulation of DNAc-jun mRNA expression by hydroxyurea in human K562 cells during erythroid differentiation [published erratum appears in Biochim Biophys Acta 1995 Dec 27;1264(3):409] | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2858 | 20.4164 | 1.0000 | In addition, HU stimulates the synthesis of proteinfetal hemoglobin in sickle cell anemia patients . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4410 | 20.7089 | 0.9999 | To further understand its mechanism of action, we investigated the effects of HU on regulation of c-jun expression prior to the onset of erythroid differentiation of cell_lineK562 cells . |
| 1.7795 | 10.5043 | 1.0000 | To further understand its mechanism of action, we investigated the effects of HU on regulation of DNAc-jun expression prior to the onset of erythroid differentiation of K562 cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5309 | 10.4101 | 1.0000 | HU induced a dose-dependent stimulation of DNAc-jun synthesis. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4887 | 20.2082 | 1.0000 | The levels of RNAc-jun mRNA was elevated 4 to 7.5-fold by HU within 2 h. |
| 1.5224 | 20.3445 | 0.9906 | The levels of DNAc-jun mRNA was elevated 4 to 7.5-fold by HU within 2 h. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5351 | 20.9629 | 1.0000 | Both nuclear run-on and actinomycin D pulse experiments strongly indicate that HU regulates c-jun mRNA expression by increasing the rate of synthesis as well as stabilizing the RNAc-jun mRNA . |
| 1.7310 | 10.6208 | 1.0000 | Both nuclear run-on and actinomycin D pulse experiments strongly indicate that HU regulates RNAc-jun mRNA expression by increasing the rate of synthesis as well as stabilizing the c-jun mRNA . |
| 0.8837 | 1.0000 | 1.0000 | Both nuclear run-on and actinomycin D pulse experiments strongly indicate that proteinHU regulates c-jun mRNA expression by increasing the rate of synthesis as well as stabilizing the c-jun mRNA . |
| Both nuclear run-on and actinomycin D pulse experiments strongly indicate that HU regulates c-jun mRNA expression by increasing the rate of synthesis as well as stabilizing the DNAc-jun mRNA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2065 | 20.6051 | 1.0000 | In addition, the level of proteinjun protein was elevated by 2 to 5-fold within 4 h in HU treated cells . |
| 1.9141 | 20.9866 | 10.6173 | In addition, the level of jun protein was elevated by 2 to 5-fold within 4 h in cell_lineHU treated cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9574 | 1.0000 | 0.9998 | Furthermore, concentrations of HU below 250 microM slightly increased the 5X AP-1 protein/CAT activity . |
| 1.5887 | 20.4182 | 0.9926 | Furthermore, concentrations of HU below 250 microM slightly increased the protein5X AP-1 /CAT activity . |
| Furthermore, concentrations of HU below 250 microM slightly increased the 5X proteinAP-1 /CAT activity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6843 | 10.4793 | 1.0000 | These results strongly suggest that HU induces both transcriptional and post-transcription regulation of DNAc-jun during erythroid differentiation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2998 | 20.2795 | 1.0000 | In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in man : relationship to proteinglucocorticoid receptors . |
| 0.9129 | 1.0000 | 1.0000 | In vivo and in vitro effects of glucocorticoids on cell_typelymphocyte proliferation in man : relationship to glucocorticoid receptors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6935 | 10.5115 | 1.0000 | While in vitro administration of glucocorticoids may inhibit concanavalin A (Con A)- and phytohemagglutinin (PHA)- induced T-cell proliferation , proteinpokeweed mitogen ( PWM )-driven B-cell mitogenesis is relatively resistant to glucocorticoids . |
| 0.9866 | 1.0000 | 1.0000 | While in vitro administration of glucocorticoids may inhibit concanavalin A (Con A)- and phytohemagglutinin (PHA)- induced T-cell proliferation , pokeweed mitogen ( proteinPWM )-driven B-cell mitogenesis is relatively resistant to glucocorticoids . |
| 0.8704 | 1.0000 | 1.0000 | While in vitro administration of glucocorticoids may inhibit concanavalin A (Con A)- and proteinphytohemagglutinin (PHA)- induced T-cell proliferation , pokeweed mitogen ( PWM )-driven B-cell mitogenesis is relatively resistant to glucocorticoids . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8789 | 10.0656 | 1.0000 | To further explore the link between the HPA and the immune system in relation to glucocorticoid receptor function , dose-response curves were obtained for Con A -and proteinPHA -induced T-cell mitogenesis , PWM -generated B-cell mitogenesis and spontaneous lymphocyte proliferation in 13 healthy controls . |
| 1.7184 | 10.8266 | 1.0000 | To further explore the link between the HPA and the immune system in relation to proteinglucocorticoid receptor function , dose-response curves were obtained for Con A -and PHA -induced T-cell mitogenesis , PWM -generated B-cell mitogenesis and spontaneous lymphocyte proliferation in 13 healthy controls . |
| 0.9522 | 1.0000 | 1.0000 | To further explore the link between the HPA and the immune system in relation to glucocorticoid receptor function , dose-response curves were obtained for Con A -and PHA -induced T-cell mitogenesis , proteinPWM -generated B-cell mitogenesis and spontaneous lymphocyte proliferation in 13 healthy controls . |
| 0.5482 | 0.9999 | 1.0000 | To further explore the link between the HPA and the immune system in relation to glucocorticoid receptor function , dose-response curves were obtained for Con A -and PHA -induced T-cell mitogenesis , PWM -generated cell_typeB-cell mitogenesis and spontaneous lymphocyte proliferation in 13 healthy controls . |
| 0.5149 | 1.0000 | 1.0000 | To further explore the link between the HPA and the immune system in relation to glucocorticoid receptor function , dose-response curves were obtained for Con A -and PHA -induced T-cell mitogenesis , PWM -generated B-cell mitogenesis and spontaneous cell_typelymphocyte proliferation in 13 healthy controls . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8780 | 10.0352 | 1.0000 | There was a significant decrease in proteinPWM -induced B-cell mitogenesis and a more pronounced effect of DEX administered in vitro on spontaneous lymphocyte proliferation after MET treatment when compared with the DEX plus MET pretreated condition in vivo. |
| 0.9051 | 1.0000 | 1.0000 | There was a significant decrease in PWM -induced cell_typeB-cell mitogenesis and a more pronounced effect of DEX administered in vitro on spontaneous lymphocyte proliferation after MET treatment when compared with the DEX plus MET pretreated condition in vivo. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3570 | 20.2602 | 1.0000 | These data suggest that the inhibition of spontaneous lymphocyte proliferation by glucocorticoids in vitro is related to proteinglucocorticoid receptor function . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7222 | 10.2264 | 1.0000 | The decrease in proteinPWM -generated B-cell proliferation following cortisol depletion by MET may be seen in connection with impaired glucocorticoid -mediated induction of interleukin-1 receptor synthesis . |
| 1.4622 | 10.8625 | 1.0000 | The decrease in PWM -generated B-cell proliferation following cortisol depletion by MET may be seen in connection with impaired glucocorticoid -mediated induction of proteininterleukin-1 receptor synthesis . |
| 1.9936 | 20.0953 | 0.9919 | The decrease in PWM -generated B-cell proliferation following cortisol depletion by MET may be seen in connection with impaired glucocorticoid -mediated induction of proteininterleukin-1 receptor synthesis . |
| 0.9209 | 0.9999 | 1.0000 | The decrease in PWM -generated cell_typeB-cell proliferation following cortisol depletion by MET may be seen in connection with impaired glucocorticoid -mediated induction of interleukin-1 receptor synthesis . |
| 0.8277 | 1.0000 | 1.0000 | The decrease in PWM -generated B-cell proliferation following cortisol depletion by proteinMET may be seen in connection with impaired glucocorticoid -mediated induction of interleukin-1 receptor synthesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0076 | 20.9523 | 10.4561 | Application of a "formamide free" and thus "material preserving" in situ hybridization technique using the cDNA of the myf3 gene revealed the following results: cell_typeHuman rhabdomyosarcoma cells , characterized by a high expression of myf3 show intensive hybridization signals in their interphase . |
| 1.7071 | 10.2254 | 1.0000 | Application of a "formamide free" and thus "material preserving" in situ hybridization technique using the DNAcDNA of the myf3 gene revealed the following results: Human rhabdomyosarcoma cells , characterized by a high expression of myf3 show intensive hybridization signals in their interphase . |
| 1.5400 | 10.4266 | 1.0000 | Application of a "formamide free" and thus "material preserving" in situ hybridization technique using the cDNA of the DNAmyf3 gene revealed the following results: Human rhabdomyosarcoma cells , characterized by a high expression of myf3 show intensive hybridization signals in their interphase . |
| 1.5450 | 10.9271 | 1.0000 | Application of a "formamide free" and thus "material preserving" in situ hybridization technique using the cDNA of the myf3 gene revealed the following results: Human rhabdomyosarcoma cells , characterized by a high expression of proteinmyf3 show intensive hybridization signals in their interphase . |
| Application of a "formamide free" and thus "material preserving" in situ hybridization technique using the cDNA of the myf3 gene revealed the following results: Human rhabdomyosarcoma cells , characterized by a high expression of DNAmyf3 show intensive hybridization signals in their interphase . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9856 | 1.0000 | 1.0000 | proteinRNase treatment prior to hybridization considerably reduces the size of this signals. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4630 | 20.1512 | 1.0000 | In comparison, isolated nuclei of cell_typehuman lymphocytes in which no need for the expression of this gene exists, show barely hybridization signals . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9304 | 1.0000 | 1.0000 | Correspondingly, proteinRNase treatment had no effect on hybridization pattern at all. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0814 | 20.9607 | 10.7871 | In conclusion an increased transcription efficiency of a DNAcell type specific gene is accompanied by a higher hybridization accessibility in the corresponding cell nuclei . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5604 | 20.9420 | 10.3620 | Oncogenicity of human papillomavirus- or adenovirus- transformed cells correlates with resistance to lysis by cell_typenatural killer cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1998 | 20.9430 | 10.6696 | The reasons for the dissimilar oncogenicities of human adenoviruses and human papillomaviruses ( HPV ) in humans are unknown but may relate to differences in the capacities of the E1A and E7 proteins to target cells for rejection by the host cell_typenatural killer (NK) cell response . |
| The reasons for the dissimilar oncogenicities of human adenoviruses and human papillomaviruses ( HPV ) in humans are unknown but may relate to differences in the capacities of the E1A and E7 proteins to cell_typetarget cells for rejection by the host natural killer (NK) cell response . | |||
| The reasons for the dissimilar oncogenicities of human adenoviruses and human papillomaviruses ( HPV ) in humans are unknown but may relate to differences in the capacities of the proteinE1A and E7 proteins to target cells for rejection by the host natural killer (NK) cell response . | |||
| The reasons for the dissimilar oncogenicities of human adenoviruses and human papillomaviruses ( HPV ) in humans are unknown but may relate to differences in the capacities of the E1A and E7 proteins to target cells for rejection by the cell_typehost natural killer (NK) cell response . | |||
| The reasons for the dissimilar oncogenicities of human adenoviruses and human papillomaviruses ( HPV ) in humans are unknown but may relate to differences in the capacities of the E1A and proteinE7 proteins to target cells for rejection by the host natural killer (NK) cell response . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2098 | 10.6183 | 10.9026 | As one test of this hypothesis, we compared the abilities of E1A -and E7 -expressing human fibroblastic or keratinocyte-derived human cells to be selectively killed by either unstimulated or cell_lineinterferon (IFN)-activated NK cells . |
| 0.9041 | 1.0000 | 1.0000 | As one test of this hypothesis, we compared the abilities of E1A -and proteinE7 -expressing human fibroblastic or keratinocyte-derived human cells to be selectively killed by either unstimulated or interferon (IFN)-activated NK cells . |
| 0.8876 | 1.0000 | 1.0000 | As one test of this hypothesis, we compared the abilities of proteinE1A -and E7 -expressing human fibroblastic or keratinocyte-derived human cells to be selectively killed by either unstimulated or interferon (IFN)-activated NK cells . |
| 3.0168 | 10.8487 | 10.9675 | As one test of this hypothesis, we compared the abilities of E1A -and E7 -expressing human fibroblastic or cell_typekeratinocyte-derived human cells to be selectively killed by either unstimulated or interferon (IFN)-activated NK cells . |
| 0.7951 | 0.9978 | 0.9991 | As one test of this hypothesis, we compared the abilities of E1A -and E7 -expressing human fibroblastic or keratinocyte-derived human cells to be selectively killed by either unstimulated or interferon (IFN)-activated cell_typeNK cells . |
| 0.5079 | 1.0000 | 0.9934 | As one test of this hypothesis, we compared the abilities of E1A -and E7 -expressing human fibroblastic or keratinocyte-derived human cells to be selectively killed by either unstimulated or proteininterferon (IFN)-activated NK cells . |
| As one test of this hypothesis, we compared the abilities of E1A -and E7 -expressing human fibroblastic or keratinocyte-derived human cells to be selectively killed by either cell_typeunstimulated or interferon (IFN)-activated NK cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3368 | 20.8191 | 1.0000 | Cells expressing the proteinE1A oncoprotein were selectively killed by unstimulated NK cells , while the same parental cells but expressing the HPV type 16 ( HPV-16 ) or HPV-18 E7 oncoprotein were resistant to NK cell lysis . |
| 1.1462 | 10.1626 | 1.0000 | Cells expressing the E1A oncoprotein were selectively killed by unstimulated NK cells , while the same cell_typeparental cells but expressing the HPV type 16 ( HPV-16 ) or HPV-18 E7 oncoprotein were resistant to NK cell lysis . |
| 3.6644 | 20.7499 | 10.7346 | Cells expressing the E1A oncoprotein were selectively killed by cell_typeunstimulated NK cells , while the same parental cells but expressing the HPV type 16 ( HPV-16 ) or HPV-18 E7 oncoprotein were resistant to NK cell lysis . |
| Cells expressing the E1A oncoprotein were selectively killed by unstimulated NK cells , while the same parental cells but expressing the HPV type 16 ( HPV-16 ) or HPV-18 proteinE7 oncoprotein were resistant to NK cell lysis . | |||
| Cells expressing the E1A oncoprotein were selectively killed by unstimulated NK cells , while the same parental cells but expressing the HPV type 16 ( HPV-16 ) or HPV-18 proteinE7 oncoprotein were resistant to NK cell lysis . | |||
| Cells expressing the E1A oncoprotein were selectively killed by cell_lineunstimulated NK cells , while the same parental cells but expressing the HPV type 16 ( HPV-16 ) or HPV-18 E7 oncoprotein were resistant to NK cell lysis . | |||
| Cells expressing the proteinE1A oncoprotein were selectively killed by unstimulated NK cells , while the same parental cells but expressing the HPV type 16 ( HPV-16 ) or HPV-18 E7 oncoprotein were resistant to NK cell lysis . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4663 | 20.9972 | 10.9094 | The ability of cell_lineIFN-activated NK cells to selectively kill virally transformed cells depends on IFN 's ability to induce resistance to NK cell lysis in normal (i.e., non-viral oncogene-expressing ) but not virally transformed cells . |
| 2.3538 | 20.3481 | 10.8425 | The ability of IFN-activated NK cells to selectively kill virally transformed cells depends on IFN 's ability to induce resistance to NK cell lysis in normal (i.e., non-viral oncogene-expressing ) but not cell_linevirally transformed cells . |
| 0.9382 | 1.0000 | 1.0000 | The ability of IFN-activated NK cells to selectively kill virally transformed cells depends on proteinIFN 's ability to induce resistance to NK cell lysis in normal (i.e., non-viral oncogene-expressing ) but not virally transformed cells . |
| 3.3513 | 20.1732 | 10.9528 | The ability of IFN-activated NK cells to selectively kill cell_linevirally transformed cells depends on IFN 's ability to induce resistance to NK cell lysis in normal (i.e., non-viral oncogene-expressing ) but not virally transformed cells . |
| 0.7775 | 0.9998 | 0.9997 | The ability of IFN-activated NK cells to selectively kill virally transformed cells depends on IFN 's ability to induce resistance to NK cell lysis in cell_typenormal (i.e., non-viral oncogene-expressing ) but not virally transformed cells . |
| The ability of IFN-activated NK cells to selectively kill virally transformed cells depends on IFN 's ability to induce resistance to NK cell lysis in normal (i.e., cell_linenon-viral oncogene-expressing ) but not virally transformed cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5622 | 20.6219 | 10.2331 | E1A blocked IFN 's induction of cytolytic resistance , resulting in the selective lysis of cell_lineadenovirus-transformed cells by IFN -activated NK cells . |
| 1.3958 | 10.5412 | 0.9887 | E1A blocked IFN 's induction of cytolytic resistance , resulting in the selective lysis of adenovirus-transformed cells by proteinIFN -activated NK cells . |
| 0.9603 | 1.0000 | 1.0000 | proteinE1A blocked IFN 's induction of cytolytic resistance , resulting in the selective lysis of adenovirus-transformed cells by IFN -activated NK cells . |
| 0.9593 | 1.0000 | 1.0000 | E1A blocked proteinIFN 's induction of cytolytic resistance , resulting in the selective lysis of adenovirus-transformed cells by IFN -activated NK cells . |
| 2.1592 | 10.5784 | 10.5894 | E1A blocked IFN 's induction of cytolytic resistance , resulting in the selective lysis of adenovirus-transformed cells by cell_typeIFN -activated NK cells . |
| E1A blocked IFN 's induction of cytolytic resistance , resulting in the selective lysis of adenovirus-transformed cells by cell_lineIFN -activated NK cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9653 | 20.8628 | 10.7805 | The extent of IFN -induced NK cell killing of cell_lineE1A -expressing cells was proportional to the level of E1A expression and correlated with the ability of E1A to block IFN -stimulated gene expression in target cells . |
| 1.5313 | 20.3237 | 0.9946 | The extent of IFN -induced NK cell killing of proteinE1A -expressing cells was proportional to the level of E1A expression and correlated with the ability of E1A to block IFN -stimulated gene expression in target cells . |
| 1.3107 | 20.4418 | 0.9998 | The extent of IFN -induced NK cell killing of E1A -expressing cells was proportional to the level of E1A expression and correlated with the ability of E1A to block IFN -stimulated gene expression in cell_typetarget cells . |
| 0.9026 | 1.0000 | 1.0000 | The extent of proteinIFN -induced NK cell killing of E1A -expressing cells was proportional to the level of E1A expression and correlated with the ability of E1A to block IFN -stimulated gene expression in target cells . |
| 0.8972 | 1.0000 | 1.0000 | The extent of IFN -induced NK cell killing of E1A -expressing cells was proportional to the level of E1A expression and correlated with the ability of E1A to block proteinIFN -stimulated gene expression in target cells . |
| 0.8877 | 10.2681 | 1.0000 | The extent of IFN -induced NK cell killing of E1A -expressing cells was proportional to the level of DNAE1A expression and correlated with the ability of E1A to block IFN -stimulated gene expression in target cells . |
| The extent of IFN -induced NK cell killing of E1A -expressing cells was proportional to the level of E1A expression and correlated with the ability of proteinE1A to block IFN -stimulated gene expression in target cells . | |||
| The extent of IFN -induced NK cell killing of E1A -expressing cells was proportional to the level of proteinE1A expression and correlated with the ability of E1A to block IFN -stimulated gene expression in target cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8452 | 20.8799 | 10.6790 | In contrast, E7 blocked neither IFN -stimulated gene expression nor IFN 's induction of cytolytic resistance , thereby precluding the selective lysis of cell_lineHPV -transformed cells by IFN -activated NK cells . |
| 1.7153 | 10.8822 | 1.0000 | In contrast, proteinE7 blocked neither IFN -stimulated gene expression nor IFN 's induction of cytolytic resistance , thereby precluding the selective lysis of HPV -transformed cells by IFN -activated NK cells . |
| 1.6829 | 10.4969 | 1.0000 | In contrast, E7 blocked neither proteinIFN -stimulated gene expression nor IFN 's induction of cytolytic resistance , thereby precluding the selective lysis of HPV -transformed cells by IFN -activated NK cells . |
| 1.2998 | 10.5292 | 0.9794 | In contrast, E7 blocked neither IFN -stimulated gene expression nor IFN 's induction of cytolytic resistance , thereby precluding the selective lysis of HPV -transformed cells by proteinIFN -activated NK cells . |
| 0.9202 | 1.0000 | 1.0000 | In contrast, E7 blocked neither IFN -stimulated gene expression nor proteinIFN 's induction of cytolytic resistance , thereby precluding the selective lysis of HPV -transformed cells by IFN -activated NK cells . |
| 2.3869 | 10.5140 | 10.6827 | In contrast, E7 blocked neither IFN -stimulated gene expression nor IFN 's induction of cytolytic resistance , thereby precluding the selective lysis of HPV -transformed cells by cell_typeIFN -activated NK cells . |
| 1.6347 | 0.9999 | 10.2006 | In contrast, E7 blocked neither IFN -stimulated gene expression nor IFN 's induction of cytolytic resistance , thereby precluding the selective lysis of HPV -transformed cells by IFN -activated cell_typeNK cells . |
| In contrast, E7 blocked neither IFN -stimulated gene expression nor IFN 's induction of cytolytic resistance , thereby precluding the selective lysis of HPV -transformed cells by cell_lineIFN -activated NK cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2384 | 20.3988 | 1.0000 | In conclusion, E1A expression marks cells for destruction by the host NK cell response , whereas the proteinE7 oncoprotein lacks this activity. |
| 2.1875 | 20.6965 | 0.9928 | In conclusion, E1A expression marks cells for destruction by the host NK cell response , whereas the proteinE7 oncoprotein lacks this activity. |
| 1.7196 | 10.8346 | 1.0000 | In conclusion, DNAE1A expression marks cells for destruction by the host NK cell response , whereas the E7 oncoprotein lacks this activity. |
| In conclusion, E1A expression marks cells for destruction by the host cell_typeNK cell response , whereas the E7 oncoprotein lacks this activity. | |||
| In conclusion, proteinE1A expression marks cells for destruction by the host NK cell response , whereas the E7 oncoprotein lacks this activity. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4821 | 10.6232 | 1.0000 | Regulation of proteinIkB alpha phosphorylation by PKC- and Ca(2+)- dependent signal transduction pathways . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3681 | 20.8003 | 10.4684 | The Ca(2+) -dependent phosphatase calcineurin , a target of FK506 and CsA , synergizes with PKC -induced activation of proteinnuclear factor (NF)-kappa B in T cell lines . |
| 3.5102 | 20.7153 | 10.5450 | The Ca(2+) -dependent phosphatase calcineurin , a target of FK506 and CsA , synergizes with PKC -induced activation of nuclear factor (NF)-kappa B in cell_lineT cell lines . |
| 2.8767 | 10.6984 | 10.3802 | The proteinCa(2+) -dependent phosphatase calcineurin , a target of FK506 and CsA , synergizes with PKC -induced activation of nuclear factor (NF)-kappa B in T cell lines . |
| 0.9342 | 1.0000 | 1.0000 | The Ca(2+) -dependent phosphatase proteincalcineurin , a target of FK506 and CsA , synergizes with PKC -induced activation of nuclear factor (NF)-kappa B in T cell lines . |
| 0.8747 | 0.9999 | 1.0000 | The Ca(2+) -dependent phosphatase calcineurin , a target of FK506 and CsA , synergizes with proteinPKC -induced activation of nuclear factor (NF)-kappa B in T cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4432 | 20.4925 | 1.0000 | We have investigated whether this synergy is present in other cell types and the mechanism(s) by which these two pathways lead to proteinNF-kappa B activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5997 | 20.6882 | 10.9546 | While this synergy is present in other cell types, in the cell_linemonocytic cell line U937 calcineurin is also sufficient to activate NF-kappa B . |
| 2.0216 | 20.0289 | 0.9999 | While this synergy is present in other cell types, in the monocytic cell line U937 calcineurin is also sufficient to activate proteinNF-kappa B . |
| 0.8944 | 1.0000 | 1.0000 | While this synergy is present in other cell types, in the monocytic cell line U937 proteincalcineurin is also sufficient to activate NF-kappa B . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3645 | 20.4898 | 1.0000 | Having previously shown that Ca(2+)- and PKC- dependent pathways synergize by accelerating the degradation of IkB alpha , we focused on the regulation of proteinIkB alpha phosphorylation . |
| 1.6126 | 10.9320 | 1.0000 | Having previously shown that Ca(2+)- and PKC- dependent pathways synergize by accelerating the degradation of proteinIkB alpha , we focused on the regulation of IkB alpha phosphorylation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2779 | 10.8199 | 10.9652 | While PKC -dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in cell_lineT cell lines , co-activation of Ca(2+) -dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. |
| 1.5700 | 10.7975 | 1.0000 | While PKC -dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines , co-activation of Ca(2+) -dependent pathways accelerates the rate of proteinIkB alpha phosphorylation and results in its complete degradation. |
| 1.5510 | 10.8462 | 1.0000 | While PKC -dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of proteinIkB alpha in T cell lines , co-activation of Ca(2+) -dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. |
| 0.9583 | 1.0000 | 1.0000 | While proteinPKC -dependent pathways sequentially result in the phosphorylation and in an incomplete degradation of IkB alpha in T cell lines , co-activation of Ca(2+) -dependent pathways accelerates the rate of IkB alpha phosphorylation and results in its complete degradation. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2975 | 20.0537 | 1.0000 | Activation of Ca(2+) -dependent pathways alone do not result in the phosphorylation and/or degradation of proteinIkB alpha in Jurkat T or in U937 cells . |
| 1.6408 | 10.7523 | 0.9999 | Activation of Ca(2+) -dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in cell_lineJurkat T or in U937 cells . |
| 1.5900 | 10.6291 | 0.9998 | Activation of Ca(2+) -dependent pathways alone do not result in the phosphorylation and/or degradation of IkB alpha in Jurkat T or in cell_lineU937 cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4191 | 20.4187 | 0.9999 | Treatment of cell_typeT cells with the selective PKC inhibitor GF109203X abrogates the PMA -induced IkB alpha phosphorylation /degradation irrespective of activation of Ca(2+) -dependent pathways , but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha , a PKC -independent stimulus . |
| 2.3665 | 20.1343 | 1.0000 | Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA -induced IkB alpha phosphorylation /degradation irrespective of activation of Ca(2+) -dependent pathways , but not the phosphorylation and degradation of proteinIkB alpha induced by TNF-alpha , a PKC -independent stimulus . |
| 1.7902 | 10.0386 | 1.0000 | Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA -induced IkB alpha phosphorylation /degradation irrespective of activation of Ca(2+) -dependent pathways , but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha , a proteinPKC -independent stimulus . |
| 1.6848 | 10.3260 | 1.0000 | Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA -induced IkB alpha phosphorylation /degradation irrespective of activation of Ca(2+) -dependent pathways , but not the phosphorylation and degradation of IkB alpha induced by proteinTNF-alpha , a PKC -independent stimulus . |
| 1.6237 | 10.6345 | 0.9999 | Treatment of T cells with the selective PKC inhibitor GF109203X abrogates the PMA -induced proteinIkB alpha phosphorylation /degradation irrespective of activation of Ca(2+) -dependent pathways , but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha , a PKC -independent stimulus . |
| 0.8764 | 1.0000 | 1.0000 | Treatment of T cells with the selective proteinPKC inhibitor GF109203X abrogates the PMA -induced IkB alpha phosphorylation /degradation irrespective of activation of Ca(2+) -dependent pathways , but not the phosphorylation and degradation of IkB alpha induced by TNF-alpha , a PKC -independent stimulus . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3784 | 20.3876 | 1.0000 | Contrary to the interaction with PKC , Ca(2+) -dependent pathways synergize with TNF-alpha not at the level of proteinIkB alpha phosphorylation , but at the level of its degradation. |
| 1.6334 | 10.4778 | 1.0000 | Contrary to the interaction with PKC , Ca(2+) -dependent pathways synergize with proteinTNF-alpha not at the level of IkB alpha phosphorylation , but at the level of its degradation. |
| 1.5840 | 10.7694 | 1.0000 | Contrary to the interaction with proteinPKC , Ca(2+) -dependent pathways synergize with TNF-alpha not at the level of IkB alpha phosphorylation , but at the level of its degradation. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4223 | 20.2074 | 1.0000 | These results indicate that Ca(2+) -dependent pathways , including the phosphatase calcineurin , participate in the regulation of proteinNF-kappa B in a cell specific fashion and synergize with PKC -dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation . |
| 1.5891 | 10.7182 | 1.0000 | These results indicate that Ca(2+) -dependent pathways , including the phosphatase calcineurin , participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC -dependent and -independent pathways at the level of proteinIkB alpha phosphorylation and degradation . |
| 0.9752 | 1.0000 | 1.0000 | These results indicate that Ca(2+) -dependent pathways , including the phosphatase proteincalcineurin , participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC -dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation . |
| 0.9197 | 1.0000 | 1.0000 | These results indicate that Ca(2+) -dependent pathways , including the phosphatase calcineurin , participate in the regulation of NF-kappa B in a cell specific fashion and synergize with proteinPKC -dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation . |
| 0.8551 | 0.9993 | 1.0000 | These results indicate that Ca(2+) -dependent pathways , including the proteinphosphatase calcineurin , participate in the regulation of NF-kappa B in a cell specific fashion and synergize with PKC -dependent and -independent pathways at the level of IkB alpha phosphorylation and degradation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8753 | 20.6778 | 10.8008 | Vitamin E therapy of acute CCl4 -induced hepatic injury in mice is associated with inhibition of proteinnuclear factor kappa B binding . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7116 | 20.6077 | 10.4748 | Oxidative stress enhances proteinnuclear factor kappa B ( NF-kappa B ) activity , and NF-kappa B activity has been shown to enhance the expression of cytotoxic cytokines . |
| 2.0407 | 20.8166 | 0.9999 | Oxidative stress enhances nuclear factor kappa B ( NF-kappa B ) activity , and NF-kappa B activity has been shown to enhance the expression of proteincytotoxic cytokines . |
| 1.4703 | 10.6474 | 0.9999 | Oxidative stress enhances nuclear factor kappa B ( NF-kappa B ) activity , and proteinNF-kappa B activity has been shown to enhance the expression of cytotoxic cytokines . |
| 0.8662 | 0.9999 | 0.9999 | Oxidative stress enhances nuclear factor kappa B ( proteinNF-kappa B ) activity , and NF-kappa B activity has been shown to enhance the expression of cytotoxic cytokines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5383 | 20.6745 | 1.0000 | Alpha-tocopherol treatment of the mice given the CCl4 also reduced the proteinNF-kappa B binding to levels approaching those found in normal mice . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.8932 | 30.8142 | 20.1151 | In vitro treatment of a monocyte/macrophage cell line with CCl4 led to enhanced NF-kappa B binding and an increase in RNAtumor necrosis factor-alpha ( TNF-alpha ) messenger RNA levels . |
| 4.1579 | 30.8923 | 10.5971 | In vitro treatment of a monocyte/macrophage cell line with CCl4 led to enhanced NF-kappa B binding and an increase in proteintumor necrosis factor-alpha ( TNF-alpha ) messenger RNA levels . |
| 1.9705 | 20.5686 | 0.9999 | In vitro treatment of a monocyte/macrophage cell line with CCl4 led to enhanced proteinNF-kappa B binding and an increase in tumor necrosis factor-alpha ( TNF-alpha ) messenger RNA levels . |
| 0.9662 | 1.0000 | 0.9975 | In vitro treatment of a monocyte/macrophage cell line with CCl4 led to enhanced NF-kappa B binding and an increase in tumor necrosis factor-alpha ( proteinTNF-alpha ) messenger RNA levels . |
| 4.1247 | 20.9651 | 10.9269 | In vitro treatment of a cell_linemonocyte/macrophage cell line with CCl4 led to enhanced NF-kappa B binding and an increase in tumor necrosis factor-alpha ( TNF-alpha ) messenger RNA levels . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5003 | 20.8194 | 1.0000 | Liver specimens taken from patients with acute fulminant hepatitis had markedly increased proteinNF-kappa B binding activity in comparison with the binding of normal livers . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4942 | 20.7733 | 1.0000 | These data demonstrate that abolishing acute hepatic injury with alpha-tocopherol , a free radical scavenger , also eliminated increased proteinNF-kappa B binding . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4408 | 20.0656 | 1.0000 | It is tempting to speculate that enhanced proteinNF-kappa B expression caused by free radical production/oxidative stress may modulate liver injury , perhaps through an effect on cytotoxic cytokine synthesis . |
| 2.4143 | 20.6712 | 1.0000 | It is tempting to speculate that enhanced NF-kappa B expression caused by free radical production/oxidative stress may modulate liver injury , perhaps through an effect on proteincytotoxic cytokine synthesis . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5783 | 20.4025 | 10.5094 | Immunosuppression by glucocorticoids : inhibition of NF-kappa B activity through induction of proteinI kappa B synthesis [see comments] |
| 2.2130 | 20.1331 | 1.0000 | Immunosuppression by glucocorticoids : inhibition of proteinNF-kappa B activity through induction of I kappa B synthesis [see comments] |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6646 | 30.2431 | 10.6952 | They inhibit synthesis of almost all known cytokines and of several proteincell surface molecules required for immune function , but the mechanism underlying this activity has been unclear. Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B ( NF-kappa B ) activation in mice and cultured cells . |
| 3.0384 | 40.9296 | 20.6782 | They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function , but the mechanism underlying this activity has been unclear. Here it is shown that glucocorticoids are potent inhibitors of proteinnuclear factor kappa B ( NF-kappa B ) activation in mice and cultured cells . |
| 1.7133 | 10.9891 | 1.0000 | They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function , but the mechanism underlying this activity has been unclear. Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B ( proteinNF-kappa B ) activation in mice and cultured cells . |
| 1.6576 | 10.3066 | 1.0000 | They inhibit synthesis of almost all known proteincytokines and of several cell surface molecules required for immune function , but the mechanism underlying this activity has been unclear. Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B ( NF-kappa B ) activation in mice and cultured cells . |
| 1.4944 | 30.2870 | 0.9995 | They inhibit synthesis of almost all known cytokines and of several cell surface molecules required for immune function , but the mechanism underlying this activity has been unclear. Here it is shown that glucocorticoids are potent inhibitors of nuclear factor kappa B ( NF-kappa B ) activation in mice and cell_linecultured cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1113 | 10.3880 | 10.5215 | This inhibition is mediated by induction of the I kappa B alpha inhibitory protein, which traps activated NF-kappa B in proteininactive cytoplasmic complexes . |
| 0.6929 | 0.9994 | 1.0000 | This inhibition is mediated by induction of the I kappa B alpha inhibitory protein, which traps activated proteinNF-kappa B in inactive cytoplasmic complexes . |
| 2.8887 | 10.4456 | 10.6562 | This inhibition is mediated by induction of the proteinI kappa B alpha inhibitory protein, which traps activated NF-kappa B in inactive cytoplasmic complexes . |
| This inhibition is mediated by induction of the proteinI kappa B alpha inhibitory protein, which traps activated NF-kappa B in inactive cytoplasmic complexes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7606 | 10.2092 | 1.0000 | Because proteinNF-kappa B activates many immunoregulatory genes in response to pro-inflammatory stimuli, the inhibition of its activity can be a major component of the anti-inflammatory activity of glucocorticoids . |
| 1.6550 | 10.6203 | 1.0000 | Because NF-kappa B activates many DNAimmunoregulatory genes in response to pro-inflammatory stimuli, the inhibition of its activity can be a major component of the anti-inflammatory activity of glucocorticoids . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0496 | 20.5068 | 10.6286 | Transcriptional repression of the interleukin-2 gene by vitamin D3 : direct inhibition of NFATp/AP-1 complex formation by a proteinnuclear hormone receptor . |
| 2.0923 | 20.5156 | 1.0000 | Transcriptional repression of the interleukin-2 gene by vitamin D3 : direct inhibition of proteinNFATp/AP-1 complex formation by a nuclear hormone receptor . |
| 2.0053 | 20.5518 | 1.0000 | Transcriptional repression of the DNAinterleukin-2 gene by vitamin D3 : direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor . |
| 1.7716 | 20.4318 | 0.9824 | Transcriptional repression of the proteininterleukin-2 gene by vitamin D3 : direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.5142 | 20.6943 | 10.8893 | T- lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [ 1,25(OH)2D3 ], the active metabolite of vitamin D3 , and is associated with a decrease in interleukin 2 (IL-2) , gamma interferon , and proteingranulocyte-macrophage colony-stimulating factor mRNA levels . |
| 1.9703 | 20.5191 | 0.9996 | T- lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [ 1,25(OH)2D3 ], the active metabolite of vitamin D3 , and is associated with a decrease in interleukin 2 (IL-2) , gamma interferon , and RNAgranulocyte-macrophage colony-stimulating factor mRNA levels . |
| 1.4286 | 10.6589 | 0.9992 | T- lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [ 1,25(OH)2D3 ], the active metabolite of vitamin D3 , and is associated with a decrease in proteininterleukin 2 (IL-2) , gamma interferon , and granulocyte-macrophage colony-stimulating factor mRNA levels . |
| 0.9207 | 0.9999 | 0.9996 | cell_typeT- lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [ 1,25(OH)2D3 ], the active metabolite of vitamin D3 , and is associated with a decrease in interleukin 2 (IL-2) , gamma interferon , and granulocyte-macrophage colony-stimulating factor mRNA levels . |
| 0.6904 | 1.0000 | 0.9657 | cell_typeT- lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [ 1,25(OH)2D3 ], the active metabolite of vitamin D3 , and is associated with a decrease in interleukin 2 (IL-2) , gamma interferon , and granulocyte-macrophage colony-stimulating factor mRNA levels . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7695 | 20.7367 | 10.6957 | We report here that 1,25(OH)2D3 -mediated repression in Jurkat cells is cycloheximide resistant , suggesting that it is a direct transcriptional repressive effect on IL-2 expression by the proteinvitamin D3 receptor ( VDR ). |
| 2.3777 | 20.3263 | 0.9999 | We report here that 1,25(OH)2D3 -mediated repression in cell_lineJurkat cells is cycloheximide resistant , suggesting that it is a direct transcriptional repressive effect on IL-2 expression by the vitamin D3 receptor ( VDR ). |
| 1.5991 | 10.8098 | 1.0000 | We report here that 1,25(OH)2D3 -mediated repression in Jurkat cells is cycloheximide resistant , suggesting that it is a direct transcriptional repressive effect on proteinIL-2 expression by the vitamin D3 receptor ( VDR ). |
| 0.9674 | 1.0000 | 1.0000 | We report here that 1,25(OH)2D3 -mediated repression in Jurkat cells is cycloheximide resistant , suggesting that it is a direct transcriptional repressive effect on IL-2 expression by the vitamin D3 receptor ( proteinVDR ). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0843 | 10.5511 | 10.8371 | We therefore examined vitamin D3 -mediated repression of activated IL-2 expression by cotransfecting Jurkat cells with DNAIL-2 promoter/reporter constructs and a VDR overexpression vector and by DNA binding . |
| 2.8220 | 20.2306 | 10.0230 | We therefore examined vitamin D3 -mediated repression of activated IL-2 expression by cotransfecting Jurkat cells with IL-2 promoter/reporter constructs and a DNAVDR overexpression vector and by DNA binding . |
| 2.2520 | 20.0372 | 0.9988 | We therefore examined vitamin D3 -mediated repression of activated IL-2 expression by cotransfecting Jurkat cells with IL-2 promoter/reporter constructs and a proteinVDR overexpression vector and by DNA binding . |
| 1.5575 | 10.4708 | 1.0000 | We therefore examined vitamin D3 -mediated repression of activated proteinIL-2 expression by cotransfecting Jurkat cells with IL-2 promoter/reporter constructs and a VDR overexpression vector and by DNA binding . |
| 1.4860 | 10.8252 | 0.9997 | We therefore examined vitamin D3 -mediated repression of activated IL-2 expression by cotransfecting cell_lineJurkat cells with IL-2 promoter/reporter constructs and a VDR overexpression vector and by DNA binding . |
| 1.4485 | 10.8476 | 0.9932 | We therefore examined vitamin D3 -mediated repression of activated IL-2 expression by cotransfecting Jurkat cells with proteinIL-2 promoter/reporter constructs and a VDR overexpression vector and by DNA binding . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.3094 | 20.7017 | 10.9142 | We delineated an element conferring both DNA binding by the receptor in vitro and 1,25(OH)2D3 -mediated repression in vivo to a short 40-bp region encompassing an important DNApositive regulatory element , NF-AT-1 , which is bound by a T-cell-specific transcription factor , NFATp , as well as by AP-1 . |
| 4.0359 | 20.9683 | 10.9782 | We delineated an element conferring both DNA binding by the receptor in vitro and 1,25(OH)2D3 -mediated repression in vivo to a short 40-bp region encompassing an important positive regulatory element , NF-AT-1 , which is bound by a proteinT-cell-specific transcription factor , NFATp , as well as by AP-1 . |
| 2.1407 | 20.2204 | 0.9999 | We delineated an element conferring both DNA binding by the receptor in vitro and 1,25(OH)2D3 -mediated repression in vivo to a short DNA40-bp region encompassing an important positive regulatory element , NF-AT-1 , which is bound by a T-cell-specific transcription factor , NFATp , as well as by AP-1 . |
| 1.5940 | 10.1046 | 1.0000 | We delineated an element conferring both DNA binding by the receptor in vitro and 1,25(OH)2D3 -mediated repression in vivo to a short 40-bp region encompassing an important positive regulatory element , NF-AT-1 , which is bound by a T-cell-specific transcription factor , NFATp , as well as by proteinAP-1 . |
| 0.9593 | 1.0000 | 1.0000 | We delineated an element conferring both DNA binding by the receptor in vitro and 1,25(OH)2D3 -mediated repression in vivo to a short 40-bp region encompassing an important positive regulatory element , NF-AT-1 , which is bound by a T-cell-specific transcription factor , proteinNFATp , as well as by AP-1 . |
| 0.9206 | 1.0000 | 1.0000 | We delineated an element conferring both DNA binding by the receptor in vitro and 1,25(OH)2D3 -mediated repression in vivo to a short 40-bp region encompassing an important positive regulatory element , DNANF-AT-1 , which is bound by a T-cell-specific transcription factor , NFATp , as well as by AP-1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1140 | 20.4352 | 0.9969 | VDR DNA-binding mutants were unable to either bind to this element in vitro or repress in vivo; the proteinVDR DNA-binding domain alone, however, bound the element but also could not repress IL-2 expression . |
| 1.7752 | 20.3348 | 10.1603 | VDR DNA-binding mutants were unable to either bind to this element in vitro or repress in vivo; the proteinVDR DNA-binding domain alone, however, bound the element but also could not repress IL-2 expression . |
| 0.9452 | 1.0000 | 0.9945 | proteinVDR DNA-binding mutants were unable to either bind to this element in vitro or repress in vivo; the VDR DNA-binding domain alone, however, bound the element but also could not repress IL-2 expression . |
| 0.8493 | 1.0000 | 1.0000 | VDR DNA-binding mutants were unable to either bind to this element in vitro or repress in vivo; the VDR DNA-binding domain alone, however, bound the element but also could not repress proteinIL-2 expression . |
| proteinVDR DNA-binding mutants were unable to either bind to this element in vitro or repress in vivo; the VDR DNA-binding domain alone, however, bound the element but also could not repress IL-2 expression . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7048 | 10.1434 | 1.0000 | These results indicate that DNA binding by VDR is necessary but not sufficient to mediate proteinIL-2 repression . |
| 1.6004 | 10.5601 | 1.0000 | These results indicate that DNA binding by proteinVDR is necessary but not sufficient to mediate IL-2 repression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0612 | 20.5457 | 10.5953 | By combining partially purified proteins in vitro, we observed the loss of the bound NFATp /AP-1-DNA complex upon inclusion of VDR or proteinVDR -retinoid X receptor . |
| 2.1742 | 20.8185 | 0.9999 | By combining partially purified proteins in vitro, we observed the loss of the bound proteinNFATp /AP-1-DNA complex upon inclusion of VDR or VDR -retinoid X receptor . |
| 1.9039 | 20.1668 | 0.9987 | By combining partially purified proteins in vitro, we observed the loss of the bound proteinNFATp /AP-1-DNA complex upon inclusion of VDR or VDR -retinoid X receptor . |
| 1.5843 | 10.0580 | 0.9979 | By combining partially purified proteins in vitro, we observed the loss of the bound NFATp /AP-1-DNA complex upon inclusion of VDR or proteinVDR -retinoid X receptor . |
| 1.5734 | 10.0675 | 1.0000 | By combining partially purified proteins in vitro, we observed the loss of the bound NFATp /AP-1-DNA complex upon inclusion of proteinVDR or VDR -retinoid X receptor . |
| By combining proteinpartially purified proteins in vitro, we observed the loss of the bound NFATp /AP-1-DNA complex upon inclusion of VDR or VDR -retinoid X receptor . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7959 | 20.2206 | 10.2771 | Order of addition and off-rate experiments indicate that the VDR -retinoid X receptor heterodimer blocks proteinNFATp / AP-1 complex formation and then stably associates with the NF-AT-1 element . |
| 3.5324 | 20.7903 | 10.8719 | Order of addition and off-rate experiments indicate that the proteinVDR -retinoid X receptor heterodimer blocks NFATp / AP-1 complex formation and then stably associates with the NF-AT-1 element . |
| 2.1377 | 20.4995 | 0.9999 | Order of addition and off-rate experiments indicate that the VDR -retinoid X receptor heterodimer blocks NFATp / AP-1 complex formation and then stably associates with the DNANF-AT-1 element . |
| 1.9631 | 20.2499 | 0.9977 | Order of addition and off-rate experiments indicate that the proteinVDR -retinoid X receptor heterodimer blocks NFATp / AP-1 complex formation and then stably associates with the NF-AT-1 element . |
| 1.5811 | 10.5405 | 0.9939 | Order of addition and off-rate experiments indicate that the VDR -retinoid X receptor heterodimer blocks proteinNFATp / AP-1 complex formation and then stably associates with the NF-AT-1 element . |
| 0.9021 | 1.0000 | 0.9641 | Order of addition and off-rate experiments indicate that the VDR -retinoid X receptor heterodimer blocks NFATp / proteinAP-1 complex formation and then stably associates with the NF-AT-1 element . |
| Order of addition and off-rate experiments indicate that the VDR -retinoid X receptor heterodimer blocks NFATp / AP-1 complex formation and then stably associates with the DNANF-AT-1 element . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1529 | 20.0746 | 0.9913 | This direct inhibition by a nuclear hormone receptor of transcriptional activators of the proteinIL-2 gene may provide a mechanistic explanation of how vitamin derivatives can act as potent immunosuppressive agents . |
| 1.5898 | 10.7777 | 0.9999 | This direct inhibition by a nuclear hormone receptor of proteintranscriptional activators of the IL-2 gene may provide a mechanistic explanation of how vitamin derivatives can act as potent immunosuppressive agents . |
| 1.5529 | 10.5819 | 1.0000 | This direct inhibition by a nuclear hormone receptor of transcriptional activators of the DNAIL-2 gene may provide a mechanistic explanation of how vitamin derivatives can act as potent immunosuppressive agents . |
| 4.3545 | 20.6198 | 10.6112 | This direct inhibition by a proteinnuclear hormone receptor of transcriptional activators of the IL-2 gene may provide a mechanistic explanation of how vitamin derivatives can act as potent immunosuppressive agents . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3605 | 20.3932 | 0.9998 | Tissue-specific regulation of the DNArabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer . |
| 1.4117 | 10.5135 | 0.9998 | Tissue-specific regulation of the rabbit 15-lipoxygenase gene in cell_typeerythroid cells by a transcriptional silencer . |
| 1.3455 | 10.6653 | 0.9997 | Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a DNAtranscriptional silencer . |
| Tissue-specific regulation of the rabbit protein15-lipoxygenase gene in erythroid cells by a transcriptional silencer . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0665 | 20.8460 | 10.7606 | The 15-lipoxygenase (lox) gene is expressed in a tissue-specific manner , predominantly in erythroid cells but also in cell_typeairway epithelial cells and eosinophils . |
| 3.2380 | 10.8494 | 10.4971 | The DNA15-lipoxygenase (lox) gene is expressed in a tissue-specific manner , predominantly in erythroid cells but also in airway epithelial cells and eosinophils . |
| 2.0262 | 20.7602 | 0.9999 | The 15-lipoxygenase (lox) gene is expressed in a tissue-specific manner , predominantly in cell_typeerythroid cells but also in airway epithelial cells and eosinophils . |
| 0.7922 | 0.9999 | 0.9999 | The 15-lipoxygenase (lox) gene is expressed in a tissue-specific manner , predominantly in erythroid cells but also in airway epithelial cells and cell_typeeosinophils . |
| 1.1740 | 1.0000 | 10.5964 | The 15-lipoxygenase (lox) gene is expressed in a tissue-specific manner , predominantly in erythroid cells but also in airway cell_typeepithelial cells and eosinophils . |
| 0.7591 | 1.0000 | 0.9966 | The protein15-lipoxygenase (lox) gene is expressed in a tissue-specific manner , predominantly in erythroid cells but also in airway epithelial cells and eosinophils . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.2831 | 20.9596 | 10.8870 | We demonstrate in this report that the 5' flanking DNA of the 15-lox gene contains sequences which down-regulate its activity in a variety of non-erythroid cell lines but not in two cell_lineerythroid cell lines . |
| 3.7570 | 20.8834 | 10.9407 | We demonstrate in this report that the 5' flanking DNA of the 15-lox gene contains sequences which down-regulate its activity in a variety of cell_linenon-erythroid cell lines but not in two erythroid cell lines . |
| 3.6071 | 20.5085 | 10.6716 | We demonstrate in this report that the DNA5' flanking DNA of the 15-lox gene contains sequences which down-regulate its activity in a variety of non-erythroid cell lines but not in two erythroid cell lines . |
| 2.1105 | 20.0405 | 1.0000 | We demonstrate in this report that the 5' flanking DNA of the DNA15-lox gene contains sequences which down-regulate its activity in a variety of non-erythroid cell lines but not in two erythroid cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| The element has characteristics of a DNAtranscriptional 'silencer' since it functions in both orientations. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7925 | 20.4919 | 10.6100 | The main activity of the silencer has been mapped to the first 900 bp of DNA5' flanking DNA , which contains nine binding sites for a nuclear factor present in non- erythroid cells but not in erythroid cells . |
| 2.0923 | 20.7943 | 0.9995 | The main activity of the silencer has been mapped to the first 900 bp of 5' flanking DNA , which contains nine binding sites for a nuclear factor present in non- erythroid cells but not in cell_typeerythroid cells . |
| 1.5504 | 10.3935 | 1.0000 | The main activity of the DNAsilencer has been mapped to the first 900 bp of 5' flanking DNA , which contains nine binding sites for a nuclear factor present in non- erythroid cells but not in erythroid cells . |
| 1.4272 | 10.8324 | 0.9999 | The main activity of the silencer has been mapped to the first 900 bp of 5' flanking DNA , which contains nine binding sites for a proteinnuclear factor present in non- erythroid cells but not in erythroid cells . |
| 1.2338 | 1.0000 | 10.3206 | The main activity of the silencer has been mapped to the first 900 bp of 5' flanking DNA , which contains nine binding sites for a nuclear factor present in non- cell_typeerythroid cells but not in erythroid cells . |
| 4.2006 | 20.5738 | 10.9379 | The main activity of the silencer has been mapped to the first 900 bp of 5' flanking DNA , which contains nine binding sites for a nuclear factor present in cell_typenon- erythroid cells but not in erythroid cells . |
| 2.0474 | 20.1693 | 0.9999 | The main activity of the silencer has been mapped to the first 900 bp of 5' flanking DNA , which contains nine DNAbinding sites for a nuclear factor present in non- erythroid cells but not in erythroid cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9225 | 20.3544 | 10.6969 | These binding sites have similar sequences and multiple copies of the binding sites confer tissue-specific down-regulation when attached to a DNAminimal lox promoter fragment . |
| 2.1829 | 20.0900 | 1.0000 | These binding sites have similar sequences and multiple copies of the DNAbinding sites confer tissue-specific down-regulation when attached to a minimal lox promoter fragment . |
| 1.4919 | 10.3552 | 0.9999 | These DNAbinding sites have similar sequences and multiple copies of the binding sites confer tissue-specific down-regulation when attached to a minimal lox promoter fragment . |
| These binding sites have similar sequences and multiple copies of the binding sites confer tissue-specific down-regulation when attached to a minimal DNAlox promoter fragment . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8547 | 10.9763 | 10.1941 | The DNA5' flanking DNA also contains a cluster of three binding sites for the GATA family of transcription factors . |
| 2.0270 | 20.2245 | 0.9999 | The 5' flanking DNA also contains a cluster of three binding sites for the proteinGATA family of transcription factors . |
| 1.5851 | 10.7495 | 0.9999 | The 5' flanking DNA also contains a cluster of three binding sites for the GATA family of proteintranscription factors . |
| The 5' flanking DNA also contains a cluster of three DNAbinding sites for the GATA family of transcription factors . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1292 | 20.3510 | 0.9998 | Phosphorylation of the proteintranscription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells . |
| 0.9725 | 1.0000 | 1.0000 | Phosphorylation of the transcription factor proteinNFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells . |
| Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and cell_typeT cells . | |||
| Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cell_linecyclosporin A-treated human B and T cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9745 | 1.0000 | 1.0000 | Cyclosporin A ( CsA ) exerts its immunosuppressive effect by inhibiting the activity of nuclear factor of activated T cells ( proteinNFAT ), thus preventing transcriptional induction of several cytokine genes. |
| 6.5969 | 30.9116 | 20.3501 | Cyclosporin A ( CsA ) exerts its immunosuppressive effect by inhibiting the activity of proteinnuclear factor of activated T cells ( NFAT ), thus preventing transcriptional induction of several cytokine genes. |
| Cyclosporin A ( CsA ) exerts its immunosuppressive effect by inhibiting the activity of nuclear factor of activated cell_typeT cells ( NFAT ), thus preventing transcriptional induction of several cytokine genes. | |||
| Cyclosporin A ( CsA ) exerts its immunosuppressive effect by inhibiting the activity of proteinnuclear factor of activated T cells ( NFAT ), thus preventing transcriptional induction of several cytokine genes. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2290 | 20.8976 | 0.9928 | This effect is thought to be largely mediated through inactivation of the phosphatase calcineurin , which in turn inhibits translocation of an proteinNFAT component to the nucleus. |
| 0.9648 | 1.0000 | 1.0000 | This effect is thought to be largely mediated through inactivation of the phosphatase proteincalcineurin , which in turn inhibits translocation of an NFAT component to the nucleus. |
| 2.2137 | 20.7841 | 1.0000 | This effect is thought to be largely mediated through inactivation of the phosphatase calcineurin , which in turn inhibits translocation of an proteinNFAT component to the nucleus. |
| 1.5541 | 10.4120 | 1.0000 | This effect is thought to be largely mediated through inactivation of the proteinphosphatase calcineurin , which in turn inhibits translocation of an NFAT component to the nucleus. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3334 | 20.4261 | 1.0000 | Here we report that CsA treatment of Raji B and Jurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an proteinNFAT complex with Fos and Jun . |
| 1.6902 | 10.4970 | 1.0000 | Here we report that CsA treatment of Raji B and Jurkat T cell lines yields a phosphorylated form of proteinNFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with Fos and Jun . |
| 0.9662 | 1.0000 | 1.0000 | Here we report that CsA treatment of Raji B and Jurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with Fos and proteinJun . |
| 0.9563 | 1.0000 | 1.0000 | Here we report that CsA treatment of Raji B and Jurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with proteinFos and Jun . |
| Here we report that CsA treatment of Raji B and cell_lineJurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with Fos and Jun . | |||
| Here we report that CsA treatment of cell_lineRaji B and Jurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with Fos and Jun . | |||
| Here we report that CsA treatment of Raji B and Jurkat cell_lineT cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with Fos and Jun . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7133 | 10.5520 | 1.0000 | Immunoblot analyses and metabolic labeling with [32P]orthophosphate show that CsA alters proteinNFATp migration on SDS-polyacrylamide gel electrophoresis by increasing its phosphorylation level without affecting subcellular distribution. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5820 | 10.6458 | 1.0000 | Dephosphorylation by in vitro treatment with calcineurin or proteinalkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an NFAT complex with Fos and Jun proteins. |
| 1.5352 | 10.9743 | 1.0000 | Dephosphorylation by in vitro treatment with calcineurin or alkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an proteinNFAT complex with Fos and Jun proteins. |
| 0.8618 | 1.0000 | 1.0000 | Dephosphorylation by in vitro treatment with calcineurin or alkaline phosphatase restores proteinNFATp DNA binding activity and its ability to reconstitute an NFAT complex with Fos and Jun proteins. |
| 0.8535 | 0.9999 | 1.0000 | Dephosphorylation by in vitro treatment with proteincalcineurin or alkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an NFAT complex with Fos and Jun proteins. |
| 0.7445 | 1.0000 | 1.0000 | Dephosphorylation by in vitro treatment with calcineurin or alkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an NFAT complex with proteinFos and Jun proteins. |
| Dephosphorylation by in vitro treatment with calcineurin or alkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an NFAT complex with Fos and proteinJun proteins. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6825 | 10.9200 | 1.0000 | These data point to a new mechanism for CsA -sensitive regulation of proteinNFATp in which dephosphorylation is critical for DNA binding. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9064 | 0.9997 | 1.0000 | proteinTranscription factors as targets for oxidative signalling during lymphocyte activation . |
| 0.6592 | 0.9999 | 0.9999 | Transcription factors as targets for oxidative signalling during cell_typelymphocyte activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5112 | 20.1779 | 1.0000 | We previously have demonstrated a requirement for oxidative events during cell cycle entry in cell_typeT lymphocytes and have hypothesised that reactive oxygen species may act as intracellular signalling agents during lymphocyte activation . |
| 0.8567 | 1.0000 | 1.0000 | We previously have demonstrated a requirement for oxidative events during cell cycle entry in T lymphocytes and have hypothesised that reactive oxygen species may act as intracellular signalling agents during cell_typelymphocyte activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8774 | 1.0000 | 1.0000 | In the current study, cysteamine , an aminothiol compound with antioxidant activity , has been used to further investigate the role of oxidative signalling during cell_typelymphocyte activation . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2690 | 20.8128 | 20.4403 | Treatment of cell_typenormal human peripheral blood lymphocytes with cysteamine in vitro was found to inhibit proliferation in a dose-dependent manner , with essentially complete inhibition occurring at a dose of 400 microM. |
| Treatment of normal cell_typehuman peripheral blood lymphocytes with cysteamine in vitro was found to inhibit proliferation in a dose-dependent manner , with essentially complete inhibition occurring at a dose of 400 microM. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2670 | 20.7812 | 1.0000 | Taking the DNAIL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation , and on the activity of transcription factors AP-1 , NF-kappa B , NF-AT and Oct1 , whose functions are required for expression of the IL-2 mRNA. |
| 2.2373 | 20.9452 | 0.9997 | Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation , and on the activity of proteintranscription factors AP-1 , NF-kappa B , NF-AT and Oct1 , whose functions are required for expression of the IL-2 mRNA. |
| 2.1442 | 20.5590 | 0.9998 | Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation , and on the activity of transcription factors AP-1 , NF-kappa B , NF-AT and Oct1 , whose functions are required for expression of the proteinIL-2 mRNA. |
| 2.0167 | 20.6268 | 0.9887 | Taking the proteinIL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation , and on the activity of transcription factors AP-1 , NF-kappa B , NF-AT and Oct1 , whose functions are required for expression of the IL-2 mRNA. |
| 0.9817 | 1.0000 | 1.0000 | Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation , and on the activity of transcription factors proteinAP-1 , NF-kappa B , NF-AT and Oct1 , whose functions are required for expression of the IL-2 mRNA. |
| 0.9792 | 1.0000 | 1.0000 | Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation , and on the activity of transcription factors AP-1 , NF-kappa B , proteinNF-AT and Oct1 , whose functions are required for expression of the IL-2 mRNA. |
| 0.9451 | 1.0000 | 1.0000 | Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation , and on the activity of transcription factors AP-1 , NF-kappa B , NF-AT and proteinOct1 , whose functions are required for expression of the IL-2 mRNA. |
| 0.8572 | 0.9995 | 1.0000 | Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation , and on the activity of transcription factors AP-1 , proteinNF-kappa B , NF-AT and Oct1 , whose functions are required for expression of the IL-2 mRNA. |
| 0.7585 | 0.9999 | 1.0000 | Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during cell_typelymphocyte activation , and on the activity of transcription factors AP-1 , NF-kappa B , NF-AT and Oct1 , whose functions are required for expression of the IL-2 mRNA. |
| Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on DNAearly gene expression during lymphocyte activation , and on the activity of transcription factors AP-1 , NF-kappa B , NF-AT and Oct1 , whose functions are required for expression of the IL-2 mRNA. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4545 | 20.1863 | 1.0000 | Cysteamine treatment inhibited both expression of the RNAIL-2 mRNA and secretion of IL-2 into the culture medium . |
| 1.9083 | 20.1912 | 0.9892 | Cysteamine treatment inhibited both expression of the proteinIL-2 mRNA and secretion of IL-2 into the culture medium . |
| 1.6513 | 10.1557 | 1.0000 | Cysteamine treatment inhibited both expression of the IL-2 mRNA and secretion of proteinIL-2 into the culture medium . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2769 | 20.4157 | 1.0000 | The inhibitory effect of cysteamine may be mediated at least in part by an effect on proteintranscription factor function , as the DNA binding activities of AP-1 and NF-kappa B extracted from mitogen-stimulated cells were significantly inhibited by cysteamine treatment . |
| 1.6331 | 10.8115 | 1.0000 | The inhibitory effect of cysteamine may be mediated at least in part by an effect on transcription factor function , as the DNA binding activities of AP-1 and proteinNF-kappa B extracted from mitogen-stimulated cells were significantly inhibited by cysteamine treatment . |
| 0.9247 | 0.9999 | 1.0000 | The inhibitory effect of cysteamine may be mediated at least in part by an effect on transcription factor function , as the DNA binding activities of proteinAP-1 and NF-kappa B extracted from mitogen-stimulated cells were significantly inhibited by cysteamine treatment . |
| 1.5462 | 10.6072 | 0.9999 | The inhibitory effect of cysteamine may be mediated at least in part by an effect on transcription factor function , as the DNA binding activities of AP-1 and NF-kappa B extracted from cell_linemitogen-stimulated cells were significantly inhibited by cysteamine treatment . |
| The inhibitory effect of cysteamine may be mediated at least in part by an effect on transcription factor function , as the DNA binding activities of AP-1 and NF-kappa B extracted from cell_typemitogen-stimulated cells were significantly inhibited by cysteamine treatment . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9356 | 0.9999 | 1.0000 | Interestingly, Oct1 and proteinNF-AT DNA binding activity were not affected by cysteamine treatment, suggesting that oxidative signalling processes operate in a selective manner. |
| 0.9247 | 0.9999 | 1.0000 | Interestingly, proteinOct1 and NF-AT DNA binding activity were not affected by cysteamine treatment, suggesting that oxidative signalling processes operate in a selective manner. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4608 | 20.4874 | 1.0000 | The identification of proteinregulatory proteins , such as transcription factors , as molecular targets for oxidative signalling provides further evidence to implicate oxidative signalling as being intimately involved in the G0 to G1 phase transition in T lymphocytes . |
| 2.3984 | 20.0053 | 0.9999 | The identification of regulatory proteins , such as transcription factors , as molecular targets for oxidative signalling provides further evidence to implicate oxidative signalling as being intimately involved in the G0 to G1 phase transition in cell_typeT lymphocytes . |
| 1.6330 | 10.9503 | 1.0000 | The identification of regulatory proteins , such as proteintranscription factors , as molecular targets for oxidative signalling provides further evidence to implicate oxidative signalling as being intimately involved in the G0 to G1 phase transition in T lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2782 | 10.9223 | 10.9104 | Sex and age distribution of 1,25(OH)2D3 receptors in cell_typeperipheral blood mononuclear cells from normal human subjects . |
| 1.6280 | 20.0700 | 0.9998 | Sex and age distribution of protein1,25(OH)2D3 receptors in peripheral blood mononuclear cells from normal human subjects . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8860 | 0.9999 | 0.9999 | Specific receptors for 1,25 Dihydroxyvitamin D3 have been described in human peripheral blood mononuclear cells ( cell_typePBMC ). |
| 5.3476 | 20.9149 | 20.0417 | Specific receptors for 1,25 Dihydroxyvitamin D3 have been described in cell_typehuman peripheral blood mononuclear cells ( PBMC ). |
| Specific receptors for 1,25 Dihydroxyvitamin D3 have been described in human cell_typeperipheral blood mononuclear cells ( PBMC ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9638 | 1.0000 | 1.0000 | The mean dissociation constant ( Kd ) was similar in both sexes (1.35 +/- 0.70 x 10(-10) M in males, 1.13 +/- 0.66 x 10(-10) M in females), but the concentration of binding sites (Nmax) was significantly lower in females (2.32 +/- 0.92 fmol/10(7) cell_typePBMC vs 4.43 +/- 1.38 fmol/10(7) PBMC in males ; p = 0.0001). |
| 0.9636 | 1.0000 | 1.0000 | The mean dissociation constant ( Kd ) was similar in both sexes (1.35 +/- 0.70 x 10(-10) M in males, 1.13 +/- 0.66 x 10(-10) M in females), but the concentration of binding sites (Nmax) was significantly lower in females (2.32 +/- 0.92 fmol/10(7) PBMC vs 4.43 +/- 1.38 fmol/10(7) cell_typePBMC in males ; p = 0.0001). |
| 1.9468 | 20.4507 | 1.0000 | The mean dissociation constant ( Kd ) was similar in both sexes (1.35 +/- 0.70 x 10(-10) M in males, 1.13 +/- 0.66 x 10(-10) M in females), but the concentration of proteinbinding sites (Nmax) was significantly lower in females (2.32 +/- 0.92 fmol/10(7) PBMC vs 4.43 +/- 1.38 fmol/10(7) PBMC in males ; p = 0.0001). |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1438 | 20.8108 | 0.9675 | Further studies are needed to elucidate if this sex difference in cell_typePBMC receptors for 1.25 Dihydroxyvitamin D3 is of any pathophysiological relevance . |
| 2.0382 | 20.9774 | 1.0000 | Further studies are needed to elucidate if this sex difference in proteinPBMC receptors for 1.25 Dihydroxyvitamin D3 is of any pathophysiological relevance . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0991 | 20.1658 | 0.9998 | Expression of Id2 and Id3 mRNA in cell_typehuman lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6029 | 0.9967 | 20.1493 | proteinHelix-loop-helix ( HLH ) transcription factors are involved in cellular growth and differentiation . |
| 0.6953 | 1.0000 | 0.9803 | proteinHelix-loop-helix ( HLH ) transcription factors are involved in cellular growth and differentiation . |
| 0.7171 | 0.9561 | 0.9996 | Helix-loop-helix ( HLH ) proteintranscription factors are involved in cellular growth and differentiation . |
| Helix-loop-helix ( proteinHLH ) transcription factors are involved in cellular growth and differentiation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.8836 | 30.4539 | 10.5898 | The Id ( inhibitor of DNA binding and differentiation ) HLH proteins , in a dominantly negative fashion, regulate transcriptional activities of proteinbasic HLH proteins . |
| 4.0332 | 10.7269 | 20.8770 | The proteinId ( inhibitor of DNA binding and differentiation ) HLH proteins , in a dominantly negative fashion, regulate transcriptional activities of basic HLH proteins . |
| The Id ( inhibitor of DNA binding and differentiation ) proteinHLH proteins , in a dominantly negative fashion, regulate transcriptional activities of basic HLH proteins . | |||
| The proteinId ( inhibitor of DNA binding and differentiation ) HLH proteins , in a dominantly negative fashion, regulate transcriptional activities of basic HLH proteins . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0613 | 20.5019 | 10.8108 | We examined by northern hybridization the expression of Id2 and Id3 mRNA in cell_linehuman leukemia/lymphoma lines and patient samples , as well as resting and activated normal human lymphocytes from peripheral blood ( PBL ). |
| 0.9319 | 1.0000 | 1.0000 | We examined by northern hybridization the expression of Id2 and Id3 mRNA in human leukemia/lymphoma lines and patient samples , as well as resting and activated normal human lymphocytes from peripheral blood ( cell_typePBL ). |
| 2.5418 | 10.9985 | 10.7868 | We examined by northern hybridization the expression of Id2 and Id3 mRNA in human leukemia/lymphoma lines and patient samples , as well as resting and activated cell_typenormal human lymphocytes from peripheral blood ( PBL ). |
| We examined by northern hybridization the expression of Id2 and Id3 mRNA in human leukemia/lymphoma lines and patient samples , as well as resting and cell_lineactivated normal human lymphocytes from peripheral blood ( PBL ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7690 | 10.5590 | 0.9999 | The RNAId2 mRNA was abundantly expressed in 5/12 T-cell and 3/4 B-cell lines , and Id3 mRNA was detected in 4/12 T-cell and 3/4 B-cell lines . |
| 1.7046 | 10.8674 | 1.0000 | The Id2 mRNA was abundantly expressed in 5/12 T-cell and 3/4 B-cell lines , and RNAId3 mRNA was detected in 4/12 T-cell and 3/4 B-cell lines . |
| 1.2787 | 10.5098 | 0.9995 | The Id2 mRNA was abundantly expressed in 5/12 T-cell and 3/4 B-cell lines , and Id3 mRNA was detected in 4/12 T-cell and 3/4 cell_lineB-cell lines . |
| 1.2603 | 10.6136 | 0.9998 | The Id2 mRNA was abundantly expressed in 5/12 T-cell and 3/4 cell_lineB-cell lines , and Id3 mRNA was detected in 4/12 T-cell and 3/4 B-cell lines . |
| 0.7496 | 1.0000 | 0.9999 | The Id2 mRNA was abundantly expressed in 5/12 cell_lineT-cell and 3/4 B-cell lines , and Id3 mRNA was detected in 4/12 T-cell and 3/4 B-cell lines . |
| The proteinId2 mRNA was abundantly expressed in 5/12 T-cell and 3/4 B-cell lines , and Id3 mRNA was detected in 4/12 T-cell and 3/4 B-cell lines . | |||
| The Id2 mRNA was abundantly expressed in 5/12 T-cell and 3/4 B-cell lines , and proteinId3 mRNA was detected in 4/12 T-cell and 3/4 B-cell lines . | |||
| The Id2 mRNA was abundantly expressed in 5/12 T-cell and cell_line3/4 B-cell lines , and Id3 mRNA was detected in 4/12 T-cell and 3/4 B-cell lines . | |||
| The Id2 mRNA was abundantly expressed in cell_line5/12 T-cell and 3/4 B-cell lines , and Id3 mRNA was detected in 4/12 T-cell and 3/4 B-cell lines . | |||
| The Id2 mRNA was abundantly expressed in 5/12 T-cell and 3/4 B-cell lines , and Id3 mRNA was detected in 4/12 T-cell and cell_line3/4 B-cell lines . | |||
| The Id2 mRNA was abundantly expressed in 5/12 T-cell and 3/4 B-cell lines , and Id3 mRNA was detected in cell_line4/12 T-cell and 3/4 B-cell lines . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7272 | 10.4548 | 1.0000 | Interestingly, Id2 , but not proteinId3 , mRNA was strongly expressed in 4/5 T-cell lines infected with human T-cell leukemia virus type I ( HTLV-I ) ( ATL-1k , MT-2 , S-LB1 ) and type II ( Mo ) . |
| 0.9417 | 0.9999 | 1.0000 | Interestingly, Id2 , but not Id3 , mRNA was strongly expressed in 4/5 T-cell lines infected with human T-cell leukemia virus type I ( HTLV-I ) ( ATL-1k , MT-2 , cell_lineS-LB1 ) and type II ( Mo ) . |
| 0.9268 | 1.0000 | 1.0000 | Interestingly, Id2 , but not Id3 , mRNA was strongly expressed in 4/5 T-cell lines infected with human T-cell leukemia virus type I ( HTLV-I ) ( ATL-1k , cell_lineMT-2 , S-LB1 ) and type II ( Mo ) . |
| 0.8899 | 1.0000 | 1.0000 | Interestingly, proteinId2 , but not Id3 , mRNA was strongly expressed in 4/5 T-cell lines infected with human T-cell leukemia virus type I ( HTLV-I ) ( ATL-1k , MT-2 , S-LB1 ) and type II ( Mo ) . |
| 0.8531 | 1.0000 | 1.0000 | Interestingly, Id2 , but not Id3 , mRNA was strongly expressed in 4/5 T-cell lines infected with human T-cell leukemia virus type I ( HTLV-I ) ( cell_lineATL-1k , MT-2 , S-LB1 ) and type II ( Mo ) . |
| 0.6122 | 0.9999 | 1.0000 | Interestingly, Id2 , but not Id3 , mRNA was strongly expressed in 4/5 T-cell lines infected with human T-cell leukemia virus type I ( HTLV-I ) ( ATL-1k , MT-2 , S-LB1 ) and type II ( cell_lineMo ) . |
| 1.4904 | 10.7977 | 0.9999 | Interestingly, Id2 , but not Id3 , mRNA was strongly expressed in 4/5 cell_lineT-cell lines infected with human T-cell leukemia virus type I ( HTLV-I ) ( ATL-1k , MT-2 , S-LB1 ) and type II ( Mo ) . |
| Interestingly, Id2 , but not Id3 , mRNA was strongly expressed in cell_line4/5 T-cell lines infected with human T-cell leukemia virus type I ( HTLV-I ) ( ATL-1k , MT-2 , S-LB1 ) and type II ( Mo ) . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6360 | 10.8867 | 0.9999 | Another unexpected finding was that T-cell leukemias and cell_lineT-cell lines often expressed either Id2 or Id3 mRNA . |
| Another unexpected finding was that T-cell leukemias and T-cell lines often expressed either Id2 or RNAId3 mRNA . | |||
| Another unexpected finding was that T-cell leukemias and T-cell lines often expressed either proteinId2 or Id3 mRNA . | |||
| Another unexpected finding was that T-cell leukemias and T-cell lines often expressed either Id2 or proteinId3 mRNA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4804 | 20.3051 | 1.0000 | In addition, resting PBL constitutively expressed prominent levels of RNAId2 mRNA , but not Id3 mRNA . |
| 2.3909 | 20.4427 | 0.9999 | In addition, resting PBL constitutively expressed prominent levels of Id2 mRNA , but not RNAId3 mRNA . |
| 1.9857 | 20.0464 | 0.9999 | In addition, cell_typeresting PBL constitutively expressed prominent levels of Id2 mRNA , but not Id3 mRNA . |
| 0.8882 | 1.0000 | 1.0000 | In addition, resting cell_typePBL constitutively expressed prominent levels of Id2 mRNA , but not Id3 mRNA . |
| In addition, resting PBL constitutively expressed prominent levels of Id2 mRNA , but not proteinId3 mRNA . | |||
| In addition, resting PBL constitutively expressed prominent levels of proteinId2 mRNA , but not Id3 mRNA . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7498 | 10.2542 | 1.0000 | Upon PHA -stimulation , proteinId2 expression decreased and Id3 levels increased with biphasic kinetics. |
| 0.9500 | 1.0000 | 1.0000 | Upon proteinPHA -stimulation , Id2 expression decreased and Id3 levels increased with biphasic kinetics. |
| 0.8721 | 1.0000 | 1.0000 | Upon PHA -stimulation , Id2 expression decreased and proteinId3 levels increased with biphasic kinetics. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.5293 | 20.9994 | 1.0000 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of RNAId2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 2.4787 | 20.6126 | 1.0000 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of RNAId3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 2.0622 | 20.5647 | 0.9917 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of proteinId2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 2.0484 | 20.7889 | 0.9926 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of proteinId3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 1.7115 | 10.5580 | 1.0000 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of RNAId2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 1.6442 | 10.4208 | 1.0000 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or RNAId3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 1.5089 | 10.5725 | 0.9875 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or proteinId3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 1.4733 | 10.6859 | 0.9955 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of proteinId2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 1.2382 | 20.0407 | 0.9883 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no proteinId3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 0.9578 | 1.0000 | 1.0000 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal cell_typePBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 0.8310 | 1.0000 | 1.0000 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either proteinId2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 0.7925 | 0.9974 | 1.0000 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no RNAId3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 0.7565 | 1.0000 | 1.0000 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of proteinId2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 3.7708 | 30.1342 | 10.7495 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) cell_typenon-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 0.8989 | 1.0000 | 1.0000 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) cell_typeT-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| 0.8509 | 1.0000 | 1.0000 | Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but cell_typeB-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related genes is disparate. |
| Taken together, our studies revealed three unexpected findings which require further analysis: (1) expression of Id2 mRNA is often associated with lymphocytic transformation by HTLV-I or -II; (2) T-cells usually express either Id2 or Id3 mRNA , but B-cells often express both simultaneously; (3) non-dividing, normal PBL express high levels of Id2 and no Id3 mRNA ; and with the onset of cellular proliferation, levels of Id2 mRNA decrease while levels of Id3 mRNA increase, suggesting that regulation of expression of these closely related DNAgenes is disparate. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.8438 | 10.6069 | 10.5315 | Salicylates inhibit lipopolysaccharide -induced transcriptional activation of the tissue factor gene in cell_typehuman monocytic cells . |
| 3.4799 | 20.2212 | 10.7385 | Salicylates inhibit lipopolysaccharide -induced transcriptional activation of the DNAtissue factor gene in human monocytic cells . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7944 | 20.4685 | 10.8958 | Binding of proteinplasma Factor VII/VIIa to the tissue factor (TF) receptor initiates the coagulation protease cascades . |
| 3.6030 | 20.2862 | 10.9471 | Binding of plasma Factor VII/VIIa to the proteintissue factor (TF) receptor initiates the coagulation protease cascades . |
| 1.2676 | 10.2626 | 0.9999 | Binding of plasma Factor VII/VIIa to the tissue factor (TF) receptor initiates the proteincoagulation protease cascades . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2370 | 20.0849 | 0.9999 | TF expression by cell_typecirculating monocytes is associated with thrombotic and inflammatory complications in a variety of diseases. |
| 0.9654 | 1.0000 | 1.0000 | proteinTF expression by circulating monocytes is associated with thrombotic and inflammatory complications in a variety of diseases. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1807 | 20.6604 | 10.8568 | Transcriptional activation of the human TF gene in monocytic cells exposed to bacterial lipopolysaccharide ( LPS ) is mediated by binding of c-Rel/p65 heterodimers to a DNAkappa B site in the TF promoter . |
| 3.7072 | 20.8779 | 10.7887 | Transcriptional activation of the DNAhuman TF gene in monocytic cells exposed to bacterial lipopolysaccharide ( LPS ) is mediated by binding of c-Rel/p65 heterodimers to a kappa B site in the TF promoter . |
| 2.1465 | 20.6372 | 0.9998 | Transcriptional activation of the human TF gene in monocytic cells exposed to bacterial lipopolysaccharide ( LPS ) is mediated by binding of c-Rel/p65 heterodimers to a kappa B site in the DNATF promoter . |
| 2.0760 | 20.6853 | 1.0000 | Transcriptional activation of the human TF gene in monocytic cells exposed to bacterial lipopolysaccharide ( LPS ) is mediated by binding of proteinc-Rel/p65 heterodimers to a kappa B site in the TF promoter . |
| 1.5091 | 10.2965 | 0.9998 | Transcriptional activation of the human TF gene in cell_typemonocytic cells exposed to bacterial lipopolysaccharide ( LPS ) is mediated by binding of c-Rel/p65 heterodimers to a kappa B site in the TF promoter . |
| 1.9765 | 20.8954 | 0.9893 | Transcriptional activation of the human TF gene in monocytic cells exposed to bacterial lipopolysaccharide ( LPS ) is mediated by binding of c-Rel/p65 heterodimers to a kappa B site in the proteinTF promoter . |
| 1.5618 | 20.8958 | 0.9679 | Transcriptional activation of the human TF gene in monocytic cells exposed to bacterial lipopolysaccharide ( LPS ) is mediated by binding of proteinc-Rel/p65 heterodimers to a kappa B site in the TF promoter . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.2180 | 10.9845 | 10.9405 | Here, we report that a family of anti-inflammatory agents , known as the salicylates, inhibited LPS induction of TF activity and TF gene transcription in human monocytes and cell_linemonocytic THP-1 cells at clinically relevant doses. |
| 1.5258 | 10.9609 | 1.0000 | Here, we report that a family of anti-inflammatory agents , known as the salicylates, inhibited LPS induction of TF activity and DNATF gene transcription in human monocytes and monocytic THP-1 cells at clinically relevant doses. |
| 1.4954 | 10.6366 | 0.9998 | Here, we report that a family of anti-inflammatory agents , known as the salicylates, inhibited LPS induction of TF activity and TF gene transcription in cell_typehuman monocytes and monocytic THP-1 cells at clinically relevant doses. |
| 1.0305 | 10.9186 | 0.9770 | Here, we report that a family of anti-inflammatory agents , known as the salicylates, inhibited LPS induction of TF activity and proteinTF gene transcription in human monocytes and monocytic THP-1 cells at clinically relevant doses. |
| 0.8875 | 1.0000 | 1.0000 | Here, we report that a family of anti-inflammatory agents , known as the salicylates, inhibited LPS induction of proteinTF activity and TF gene transcription in human monocytes and monocytic THP-1 cells at clinically relevant doses. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8824 | 20.7110 | 10.8138 | Furthermore, sodium salicylate blocked the LPS -induced proteolytic degradation of proteinI kappa B alpha , which prevented the nuclear translocation of c-Rel/p65 heterodimers . |
| 2.1244 | 20.7404 | 0.9999 | Furthermore, sodium salicylate blocked the LPS -induced proteolytic degradation of I kappa B alpha , which prevented the nuclear translocation of proteinc-Rel/p65 heterodimers . |
| 1.9878 | 20.8863 | 0.9755 | Furthermore, sodium salicylate blocked the LPS -induced proteolytic degradation of I kappa B alpha , which prevented the nuclear translocation of proteinc-Rel/p65 heterodimers . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.3839 | 20.6799 | 1.0000 | In contrast, two other nonsteroidal anti-inflammatory drugs , ibuprofen and indomethacin , did not inhibit LPS induction of the DNATF gene . |
| 2.0734 | 20.6191 | 0.9843 | In contrast, two other nonsteroidal anti-inflammatory drugs , ibuprofen and indomethacin , did not inhibit LPS induction of the proteinTF gene . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2282 | 20.2720 | 0.9999 | These results indicated that salicylates inhibited LPS induction of TF gene transcription in monocytic cells by preventing nuclear translocation of proteinc-Rel/p65 heterodimers . |
| 1.4952 | 10.7686 | 1.0000 | These results indicated that salicylates inhibited LPS induction of DNATF gene transcription in monocytic cells by preventing nuclear translocation of c-Rel/p65 heterodimers . |
| 1.4503 | 10.7525 | 0.9999 | These results indicated that salicylates inhibited LPS induction of TF gene transcription in cell_typemonocytic cells by preventing nuclear translocation of c-Rel/p65 heterodimers . |
| 2.1182 | 20.6670 | 0.9858 | These results indicated that salicylates inhibited LPS induction of TF gene transcription in monocytic cells by preventing nuclear translocation of proteinc-Rel/p65 heterodimers . |
| 1.2623 | 10.7930 | 0.9905 | These results indicated that salicylates inhibited LPS induction of proteinTF gene transcription in monocytic cells by preventing nuclear translocation of c-Rel/p65 heterodimers . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5038 | 20.2149 | 1.0000 | The clinical benefits of salicylates in the treatment of several diseases, including atherosclerosis and rheumatoid arthritis , may be related to their ability to reduce DNAmonocyte gene expression . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9762 | 1.0000 | 1.0000 | Activation of the signal transducer and transcription ( proteinSTAT ) signaling pathway in a primary T cell response . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.7269 | 0.9999 | 1.0000 | Critical role for proteinIL-6 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.9645 | 1.0000 | 1.0000 | The T cell activation is initiated by interaction of specific Ags with proteinTCR , followed by activation of intracellular biochemical events leading to activation of several genes. |
| 0.6369 | 1.0000 | 1.0000 | The T cell activation is initiated by interaction of specific proteinAgs with TCR , followed by activation of intracellular biochemical events leading to activation of several genes. |
| 2.3472 | 20.5678 | 1.0000 | The T cell activation is initiated by interaction of proteinspecific Ags with TCR , followed by activation of intracellular biochemical events leading to activation of several genes. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.1723 | 20.1428 | 0.9998 | The activation of signal transducer and activator of transcription (STAT) proteins in a primary TCR -mediated activation of cell_typeT cells have been explored. |
| 0.8806 | 1.0000 | 1.0000 | The activation of signal transducer and activator of transcription (STAT) proteins in a primary proteinTCR -mediated activation of T cells have been explored. |
| 4.8142 | 30.8059 | 20.3787 | The activation of proteinsignal transducer and activator of transcription (STAT) proteins in a primary TCR -mediated activation of T cells have been explored. |
| 1.5330 | 20.3148 | 0.9997 | The activation of signal transducer and activator of transcription (STAT) proteins in a proteinprimary TCR -mediated activation of T cells have been explored. |
| The activation of signal transducer and activator of proteintranscription (STAT) proteins in a primary TCR -mediated activation of T cells have been explored. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.6234 | 10.5746 | 20.3673 | In cell_typepurified human peripheral blood T cells , nuclear STAT proteins were activated approximately 3 h after activation by cross-linked anti-CD3 Abs . |
| 1.9339 | 30.9173 | 10.1488 | In purified human peripheral blood T cells , nuclear STAT proteins were activated approximately 3 h after activation by proteincross-linked anti-CD3 Abs . |
| 1.8989 | 20.7543 | 0.9999 | In purified human peripheral blood T cells , nuclear proteinSTAT proteins were activated approximately 3 h after activation by cross-linked anti-CD3 Abs . |
| In purified human peripheral blood T cells , proteinnuclear STAT proteins were activated approximately 3 h after activation by cross-linked anti-CD3 Abs . | |||
| In purified human peripheral blood T cells , nuclear STAT proteins were activated approximately 3 h after activation by cross-linked proteinanti-CD3 Abs . | |||
| In purified human peripheral blood cell_typeT cells , nuclear STAT proteins were activated approximately 3 h after activation by cross-linked anti-CD3 Abs . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5944 | 10.8835 | 1.0000 | These STAT proteins were detected by using the DNAIFN-gamma-activated sequence ( GAS ) and related oligonucleotides as probes in electrophoretic mobility shift assay . |
| 1.5513 | 10.1822 | 1.0000 | These proteinSTAT proteins were detected by using the IFN-gamma-activated sequence ( GAS ) and related oligonucleotides as probes in electrophoretic mobility shift assay . |
| 0.9503 | 1.0000 | 1.0000 | These STAT proteins were detected by using the IFN-gamma-activated sequence ( DNAGAS ) and related oligonucleotides as probes in electrophoretic mobility shift assay . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6393 | 10.2165 | 1.0000 | Analysis of the nuclear extracts with anti-STAT Abs indicated that they contained proteinSTAT-3 and additional proteins crossreactive with the STAT family . |
| 1.5448 | 10.9848 | 1.0000 | Analysis of the nuclear extracts with proteinanti-STAT Abs indicated that they contained STAT-3 and additional proteins crossreactive with the STAT family . |
| 1.4508 | 10.8084 | 0.9999 | Analysis of the nuclear extracts with anti-STAT Abs indicated that they contained STAT-3 and additional proteins crossreactive with the proteinSTAT family . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.9991 | 30.1343 | 0.9993 | The induction of proteinSTAT activity was inhibited completely by pretreatment with either cycloheximide or cyclosporin A , thus indicating that the induction was due to a secondary factor produced by the activated T cells . |
| 2.3582 | 20.8233 | 1.0000 | The induction of STAT activity was inhibited completely by pretreatment with either cycloheximide or cyclosporin A , thus indicating that the induction was due to a proteinsecondary factor produced by the activated T cells . |
| 3.8173 | 20.8271 | 10.9785 | The induction of STAT activity was inhibited completely by pretreatment with either cycloheximide or cyclosporin A , thus indicating that the induction was due to a secondary factor produced by the cell_typeactivated T cells . |
| 1.5947 | 20.7997 | 1.0000 | The induction of proteinSTAT activity was inhibited completely by pretreatment with either cycloheximide or cyclosporin A , thus indicating that the induction was due to a secondary factor produced by the activated T cells . |
| The induction of STAT activity was inhibited completely by pretreatment with either cycloheximide or cyclosporin A , thus indicating that the induction was due to a secondary factor produced by the activated cell_typeT cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2377 | 20.7347 | 1.0000 | As neutralizing anti- IL-6 Abs effectively down-regulated the early induction of STAT proteins and as exogenously added IL-6 rapidly activated DNA binding similar to TCR -mediated bindings , it can be concluded that IL-6 is the factor responsible for the activation of proteinSTAT proteins in a primary T cell response . |
| 2.1881 | 20.4767 | 1.0000 | As neutralizing anti- IL-6 Abs effectively down-regulated the early induction of proteinSTAT proteins and as exogenously added IL-6 rapidly activated DNA binding similar to TCR -mediated bindings , it can be concluded that IL-6 is the factor responsible for the activation of STAT proteins in a primary T cell response . |
| 1.9088 | 20.5662 | 0.9883 | As neutralizing anti- proteinIL-6 Abs effectively down-regulated the early induction of STAT proteins and as exogenously added IL-6 rapidly activated DNA binding similar to TCR -mediated bindings , it can be concluded that IL-6 is the factor responsible for the activation of STAT proteins in a primary T cell response . |
| 1.6375 | 10.3368 | 1.0000 | As neutralizing anti- IL-6 Abs effectively down-regulated the early induction of STAT proteins and as exogenously added proteinIL-6 rapidly activated DNA binding similar to TCR -mediated bindings , it can be concluded that IL-6 is the factor responsible for the activation of STAT proteins in a primary T cell response . |
| 0.9106 | 1.0000 | 1.0000 | As neutralizing anti- IL-6 Abs effectively down-regulated the early induction of STAT proteins and as exogenously added IL-6 rapidly activated DNA binding similar to TCR -mediated bindings , it can be concluded that proteinIL-6 is the factor responsible for the activation of STAT proteins in a primary T cell response . |
| 0.9030 | 1.0000 | 1.0000 | As neutralizing anti- IL-6 Abs effectively down-regulated the early induction of STAT proteins and as exogenously added IL-6 rapidly activated DNA binding similar to proteinTCR -mediated bindings , it can be concluded that IL-6 is the factor responsible for the activation of STAT proteins in a primary T cell response . |
| 2.3776 | 20.8154 | 10.2336 | As neutralizing proteinanti- IL-6 Abs effectively down-regulated the early induction of STAT proteins and as exogenously added IL-6 rapidly activated DNA binding similar to TCR -mediated bindings , it can be concluded that IL-6 is the factor responsible for the activation of STAT proteins in a primary T cell response . |
| As proteinneutralizing anti- IL-6 Abs effectively down-regulated the early induction of STAT proteins and as exogenously added IL-6 rapidly activated DNA binding similar to TCR -mediated bindings , it can be concluded that IL-6 is the factor responsible for the activation of STAT proteins in a primary T cell response . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7110 | 20.9621 | 10.4043 | The normal cell cycle activation program is exploited during the infection of cell_typequiescent B lymphocytes by Epstein-Barr virus . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 0.8895 | 0.9988 | 0.9999 | cell_typeB lymphocytes in the peripheral circulation are maintained in a non-proliferative state . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.1336 | 20.8383 | 10.3523 | Antigen recognition stimulates limited proliferation, whereas infection with Epstein-Barr virus ( EBV ) results in continual proliferation and the outgrowth of cell_lineimmortal cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.5440 | 30.0598 | 10.8571 | Because it is not clear at which point in cell cycle the peripheral B lymphocytes are arrested, we characterized the expression of several DNAcell cycle-associated genes in quiescent and stimulated cells . |
| 3.8527 | 20.7763 | 10.9256 | Because it is not clear at which point in cell cycle the cell_typeperipheral B lymphocytes are arrested, we characterized the expression of several cell cycle-associated genes in quiescent and stimulated cells . |
| Because it is not clear at which point in cell cycle the peripheral cell_typeB lymphocytes are arrested, we characterized the expression of several cell cycle-associated genes in quiescent and stimulated cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.9607 | 10.6162 | 10.1019 | We show that the expression of four DNAcell genes , cdc-2 , cyclin E , CD23 , and cyclin D2 , are up-regulated approximately 100-fold as a result of EBV -mediated immortalization . |
| 1.8327 | 10.0851 | 1.0000 | We show that the expression of four cell genes , DNAcdc-2 , cyclin E , CD23 , and cyclin D2 , are up-regulated approximately 100-fold as a result of EBV -mediated immortalization . |
| 1.5999 | 10.3470 | 1.0000 | We show that the expression of four cell genes , cdc-2 , DNAcyclin E , CD23 , and cyclin D2 , are up-regulated approximately 100-fold as a result of EBV -mediated immortalization . |
| 1.5845 | 10.5712 | 1.0000 | We show that the expression of four cell genes , cdc-2 , cyclin E , CD23 , and DNAcyclin D2 , are up-regulated approximately 100-fold as a result of EBV -mediated immortalization . |
| 0.9457 | 1.0000 | 1.0000 | We show that the expression of four cell genes , cdc-2 , cyclin E , DNACD23 , and cyclin D2 , are up-regulated approximately 100-fold as a result of EBV -mediated immortalization . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8454 | 20.5096 | 10.7665 | Transient stimulation of cell_typequiescent B lymphocytes with either a cocktail of anti-CD40 , anti-IgM , and IL4 , or EBV results in the rapid expression of the same four genes, suggesting that, after infection, EBV exploits the normal program of B-lymphocyte cell cycle activation . |
| 1.7572 | 10.2938 | 1.0000 | Transient stimulation of quiescent B lymphocytes with either a cocktail of proteinanti-CD40 , anti-IgM , and IL4 , or EBV results in the rapid expression of the same four genes, suggesting that, after infection, EBV exploits the normal program of B-lymphocyte cell cycle activation . |
| 1.7025 | 10.4775 | 1.0000 | Transient stimulation of quiescent B lymphocytes with either a cocktail of anti-CD40 , anti-IgM , and proteinIL4 , or EBV results in the rapid expression of the same four genes, suggesting that, after infection, EBV exploits the normal program of B-lymphocyte cell cycle activation . |
| 0.9450 | 1.0000 | 1.0000 | Transient stimulation of quiescent B lymphocytes with either a cocktail of anti-CD40 , proteinanti-IgM , and IL4 , or EBV results in the rapid expression of the same four genes, suggesting that, after infection, EBV exploits the normal program of B-lymphocyte cell cycle activation . |
| 0.8746 | 0.9998 | 1.0000 | Transient stimulation of quiescent B lymphocytes with either a cocktail of anti-CD40 , anti-IgM , and IL4 , or EBV results in the rapid expression of the same four genes, suggesting that, after infection, EBV exploits the normal program of cell_typeB-lymphocyte cell cycle activation . |
| Transient stimulation of quiescent cell_typeB lymphocytes with either a cocktail of anti-CD40 , anti-IgM , and IL4 , or EBV results in the rapid expression of the same four genes, suggesting that, after infection, EBV exploits the normal program of B-lymphocyte cell cycle activation . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.0060 | 20.8956 | 20.3990 | Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by proteinEpstein-Barr virus nuclear antigen 2 . |
| 1.6822 | 20.6357 | 0.9990 | Expression of the proteinchemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2 . |
| 0.9408 | 0.9999 | 1.0000 | Expression of the chemokine receptor proteinBLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9270 | 20.8910 | 10.9981 | In our attempt to identify chemokine receptors that are related to proteinBurkitt's lymphoma receptor 1 ( BLR1 ) and are expressed in activated lymphocytes we used RT-PCR resulting in the isolation of a cDNA encoding a seven transmembrane receptor termed BLR2 . |
| 3.5636 | 20.9890 | 10.9068 | In our attempt to identify chemokine receptors that are related to Burkitt's lymphoma receptor 1 ( BLR1 ) and are expressed in activated lymphocytes we used RT-PCR resulting in the isolation of a cDNA encoding a proteinseven transmembrane receptor termed BLR2 . |
| 1.3856 | 10.9662 | 0.9999 | In our attempt to identify proteinchemokine receptors that are related to Burkitt's lymphoma receptor 1 ( BLR1 ) and are expressed in activated lymphocytes we used RT-PCR resulting in the isolation of a cDNA encoding a seven transmembrane receptor termed BLR2 . |
| 1.2758 | 10.8568 | 0.9997 | In our attempt to identify chemokine receptors that are related to Burkitt's lymphoma receptor 1 ( BLR1 ) and are expressed in cell_typeactivated lymphocytes we used RT-PCR resulting in the isolation of a cDNA encoding a seven transmembrane receptor termed BLR2 . |
| 0.9708 | 1.0000 | 1.0000 | In our attempt to identify chemokine receptors that are related to Burkitt's lymphoma receptor 1 ( proteinBLR1 ) and are expressed in activated lymphocytes we used RT-PCR resulting in the isolation of a cDNA encoding a seven transmembrane receptor termed BLR2 . |
| 0.8920 | 1.0000 | 1.0000 | In our attempt to identify chemokine receptors that are related to Burkitt's lymphoma receptor 1 ( BLR1 ) and are expressed in activated lymphocytes we used RT-PCR resulting in the isolation of a cDNA encoding a seven transmembrane receptor termed proteinBLR2 . |
| 1.5561 | 10.0642 | 1.0000 | In our attempt to identify chemokine receptors that are related to Burkitt's lymphoma receptor 1 ( BLR1 ) and are expressed in activated lymphocytes we used RT-PCR resulting in the isolation of a DNAcDNA encoding a seven transmembrane receptor termed BLR2 . |
| 0.8692 | 1.0000 | 0.9999 | In our attempt to identify chemokine receptors that are related to Burkitt's lymphoma receptor 1 ( BLR1 ) and are expressed in activated cell_typelymphocytes we used RT-PCR resulting in the isolation of a cDNA encoding a seven transmembrane receptor termed BLR2 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9324 | 20.9386 | 10.7696 | The protein shows significant sequence similarities to the family of proteinG-protein coupled chemokine receptors and turned out to be identical to the recently described receptor EBI1 . |
| 2.0449 | 20.0693 | 0.9999 | The protein shows significant sequence similarities to the family of G-protein coupled chemokine receptors and turned out to be identical to the recently described proteinreceptor EBI1 . |
| 0.8441 | 0.9995 | 0.9999 | The protein shows significant sequence similarities to the family of G-protein coupled proteinchemokine receptors and turned out to be identical to the recently described receptor EBI1 . |
| 0.5139 | 1.0000 | 1.0000 | The protein shows significant sequence similarities to the family of G-protein coupled chemokine receptors and turned out to be identical to the recently described receptor proteinEBI1 . |
| The protein shows significant sequence similarities to the family of proteinG-protein coupled chemokine receptors and turned out to be identical to the recently described receptor EBI1 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.4028 | 20.0940 | 1.0000 | Northern blot analysis revealed that RNABLR2 mRNA could be highly stimulated in mitogen- and anti-CD3- treated peripheral blood lymphocytes . |
| 1.9950 | 20.1325 | 0.9954 | Northern blot analysis revealed that proteinBLR2 mRNA could be highly stimulated in mitogen- and anti-CD3- treated peripheral blood lymphocytes . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.8860 | 30.4520 | 20.1967 | BLR2 -specific mRNA could be detected in all cell_lineEpstein-Barr virus positive B cell lines . |
| 0.9582 | 1.0000 | 0.9998 | proteinBLR2 -specific mRNA could be detected in all Epstein-Barr virus positive B cell lines . |
| 0.5415 | 0.8507 | 0.9998 | RNABLR2 -specific mRNA could be detected in all Epstein-Barr virus positive B cell lines . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.2510 | 30.9578 | 20.4714 | We show that transcription of the BLR2 gene could be specifically induced in cell_lineEpstein-Barr virus negative BL 41 cells via estrogen-mediated activation of Epstein-Barr virus nuclear antigen 2 , a key regulator of viral and cellular genes in immortalized B cells . |
| 5.0533 | 30.4028 | 20.0640 | We show that transcription of the BLR2 gene could be specifically induced in Epstein-Barr virus negative BL 41 cells via estrogen-mediated activation of proteinEpstein-Barr virus nuclear antigen 2 , a key regulator of viral and cellular genes in immortalized B cells . |
| 1.8348 | 20.9459 | 1.0000 | We show that transcription of the DNABLR2 gene could be specifically induced in Epstein-Barr virus negative BL 41 cells via estrogen-mediated activation of Epstein-Barr virus nuclear antigen 2 , a key regulator of viral and cellular genes in immortalized B cells . |
| 1.7519 | 20.9117 | 0.9927 | We show that transcription of the proteinBLR2 gene could be specifically induced in Epstein-Barr virus negative BL 41 cells via estrogen-mediated activation of Epstein-Barr virus nuclear antigen 2 , a key regulator of viral and cellular genes in immortalized B cells . |
| 1.3475 | 0.9832 | 10.0267 | We show that transcription of the BLR2 gene could be specifically induced in Epstein-Barr virus negative BL 41 cells via estrogen-mediated activation of Epstein-Barr virus nuclear antigen 2 , a key regulator of viral and cellular genes in cell_lineimmortalized B cells . |
| We show that transcription of the BLR2 gene could be specifically induced in Epstein-Barr virus negative BL 41 cells via estrogen-mediated activation of Epstein-Barr virus nuclear antigen 2 , a key regulator of DNAviral and cellular genes in immortalized B cells . | |||
| We show that transcription of the BLR2 gene could be specifically induced in Epstein-Barr virus negative BL 41 cells via estrogen-mediated activation of Epstein-Barr virus nuclear antigen 2 , a key regulator of viral and DNAcellular genes in immortalized B cells . | |||
| We show that transcription of the BLR2 gene could be specifically induced in Epstein-Barr virus negative BL 41 cells via estrogen-mediated activation of Epstein-Barr virus nuclear antigen 2 , a key regulator of DNAviral and cellular genes in immortalized B cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2778 | 20.1925 | 1.0000 | Our data suggest an involvement of proteinBLR2 in the regulation of migration in activated lymphocytes and in viral pathogenesis . |
| 0.9309 | 1.0000 | 1.0000 | Our data suggest an involvement of BLR2 in the regulation of migration in activated cell_typelymphocytes and in viral pathogenesis . |
| Our data suggest an involvement of BLR2 in the regulation of migration in cell_typeactivated lymphocytes and in viral pathogenesis . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.6591 | 20.3568 | 10.7893 | A central role for a single c-Myb binding site in a DNAthymic locus control region . |
| 3.3024 | 20.4082 | 10.7641 | A central role for a single DNAc-Myb binding site in a thymic locus control region . |
| A central role for a DNAsingle c-Myb binding site in a thymic locus control region . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.4542 | 20.7922 | 10.6094 | Locus control regions ( LCRs ) are powerful assemblies of cis elements that organize the actions of proteincell-type-specific trans-acting factors . |
| 1.9441 | 20.2241 | 0.9999 | Locus control regions ( LCRs ) are powerful assemblies of DNAcis elements that organize the actions of cell-type-specific trans-acting factors . |
| 1.4606 | 0.9980 | 10.6391 | DNALocus control regions ( LCRs ) are powerful assemblies of cis elements that organize the actions of cell-type-specific trans-acting factors . |
| 0.9501 | 1.0000 | 1.0000 | Locus control regions ( DNALCRs ) are powerful assemblies of cis elements that organize the actions of cell-type-specific trans-acting factors . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.7054 | 30.2481 | 20.5713 | A 2.3-kb LCR in the DNAhuman adenosine deaminase (ADA) gene first intron , which controls expression in thymocytes , is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin . |
| 3.9108 | 20.9596 | 10.9876 | A 2.3-kb LCR in the human adenosine deaminase (ADA) gene first intron , which controls expression in thymocytes , is composed of a DNA200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin . |
| 1.4533 | 10.0240 | 1.0000 | A 2.3-kb LCR in the human adenosine deaminase (ADA) gene first intron , which controls expression in cell_typethymocytes , is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin . |
| 1.3405 | 10.6535 | 1.0000 | A 2.3-kb LCR in the human adenosine deaminase (ADA) gene first intron , which controls expression in thymocytes , is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within DNAchromatin . |
| 2.7063 | 20.1810 | 10.5779 | A 2.3-kb LCR in the proteinhuman adenosine deaminase (ADA) gene first intron , which controls expression in thymocytes , is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin . |
| 1.6652 | 20.6754 | 0.9998 | A 2.3-kb LCR in the human adenosine deaminase (ADA) gene first intron , which controls expression in thymocytes , is composed of a 200-bp enhancer domain and extended DNAflanking sequences that facilitate activation from within chromatin . |
| 1.2897 | 10.6066 | 0.9991 | A DNA2.3-kb LCR in the human adenosine deaminase (ADA) gene first intron , which controls expression in thymocytes , is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin . |
| 0.5606 | 1.0000 | 0.9998 | A 2.3-kb DNALCR in the human adenosine deaminase (ADA) gene first intron , which controls expression in thymocytes , is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin . |
| A 2.3-kb LCR in the DNAhuman adenosine deaminase (ADA) gene first intron , which controls expression in thymocytes , is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin . | |||
| A protein2.3-kb LCR in the human adenosine deaminase (ADA) gene first intron , which controls expression in thymocytes , is composed of a 200-bp enhancer domain and extended flanking sequences that facilitate activation from within chromatin . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6757 | 10.8519 | 10.7748 | Prior analyses have demonstrated that the enhancer contains a DNA28-bp core region and local adjacent augmentative cis elements . |
| 4.7697 | 20.9982 | 20.7290 | Prior analyses have demonstrated that the enhancer contains a 28-bp core region and DNAlocal adjacent augmentative cis elements . |
| Prior analyses have demonstrated that the DNAenhancer contains a 28-bp core region and local adjacent augmentative cis elements . | |||
| Prior analyses have demonstrated that the enhancer contains a 28-bp core region and local adjacent augmentative DNAcis elements . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.7082 | 20.5312 | 10.4767 | We now show that the core contains a single critical DNAc-Myb binding site . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.8681 | 30.1247 | 10.5759 | In both transiently cotransfected human cells and stable chromatin-integrated yeast cells , c-Myb strongly transactivated reporter constructs that contained DNApolymerized core sequences . |
| 3.7249 | 20.2250 | 10.8508 | In both cell_linetransiently cotransfected human cells and stable chromatin-integrated yeast cells , c-Myb strongly transactivated reporter constructs that contained polymerized core sequences . |
| 1.2831 | 0.9988 | 10.7122 | In both transiently cotransfected human cells and stable cell_linechromatin-integrated yeast cells , c-Myb strongly transactivated reporter constructs that contained polymerized core sequences . |
| 0.9419 | 1.0000 | 1.0000 | In both transiently cotransfected human cells and stable chromatin-integrated yeast cells , proteinc-Myb strongly transactivated reporter constructs that contained polymerized core sequences . |
| In both transiently cotransfected human cells and stable chromatin-integrated yeast cells , c-Myb strongly DNAtransactivated reporter constructs that contained polymerized core sequences . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2250 | 20.7382 | 0.9999 | c-Myb protein was strongly evident in cell_typeT lymphoblasts in which the enhancer was active and was localized within discrete nuclear structures . |
| 0.9321 | 1.0000 | 0.9927 | proteinc-Myb protein was strongly evident in T lymphoblasts in which the enhancer was active and was localized within discrete nuclear structures . |
| 0.8839 | 0.9980 | 0.9999 | proteinc-Myb protein was strongly evident in T lymphoblasts in which the enhancer was active and was localized within discrete nuclear structures . |
| c-Myb protein was strongly evident in T lymphoblasts in which the DNAenhancer was active and was localized within discrete nuclear structures . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.7325 | 10.5309 | 1.0000 | Fetal murine thymus exhibited a striking concordance of endogenous DNAc-myb expression with that of mouse ADA and human ADA LCR -directed transgene expression . |
| 1.1603 | 10.4022 | 0.8702 | Fetal murine thymus exhibited a striking concordance of endogenous c-myb expression with that of mouse ADA and DNAhuman ADA LCR -directed transgene expression . |
| 2.2224 | 20.1592 | 0.9999 | Fetal murine thymus exhibited a striking concordance of endogenous c-myb expression with that of proteinmouse ADA and human ADA LCR -directed transgene expression . |
| Fetal murine thymus exhibited a striking concordance of endogenous c-myb expression with that of DNAmouse ADA and human ADA LCR -directed transgene expression . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1476 | 20.4186 | 1.0000 | Point mutation of the DNAc-Myb site within the intact 2.3-kb LCR severely attenuated enhancer activity in transfections and LCR activity in transgenic thymocytes . |
| 0.8692 | 1.0000 | 1.0000 | Point mutation of the c-Myb site within the intact 2.3-kb LCR severely attenuated enhancer activity in transfections and DNALCR activity in transgenic thymocytes . |
| 2.1998 | 20.1046 | 0.9999 | Point mutation of the c-Myb site within the intact DNA2.3-kb LCR severely attenuated enhancer activity in transfections and LCR activity in transgenic thymocytes . |
| 1.4101 | 10.6075 | 0.9997 | Point mutation of the c-Myb site within the intact 2.3-kb LCR severely attenuated enhancer activity in transfections and LCR activity in cell_typetransgenic thymocytes . |
| 0.5403 | 1.0000 | 1.0000 | Point mutation of the c-Myb site within the intact 2.3-kb LCR severely attenuated DNAenhancer activity in transfections and LCR activity in transgenic thymocytes . |
| 0.5219 | 1.0000 | 1.0000 | Point mutation of the c-Myb site within the intact 2.3-kb DNALCR severely attenuated enhancer activity in transfections and LCR activity in transgenic thymocytes . |
| Point mutation of the c-Myb site within the intact 2.3-kb LCR severely attenuated enhancer activity in transfections and LCR activity in transgenic cell_typethymocytes . | |||
| Point mutation of the c-Myb site within the intact 2.3-kb LCR severely attenuated enhancer activity in transfections and LCR activity in cell_linetransgenic thymocytes . | |||
| Point mutation of the c-Myb site within the intact protein2.3-kb LCR severely attenuated enhancer activity in transfections and LCR activity in transgenic thymocytes . | |||
| Point mutation of the proteinc-Myb site within the intact 2.3-kb LCR severely attenuated enhancer activity in transfections and LCR activity in transgenic thymocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.0061 | 20.3557 | 0.9999 | Within the context of a DNAcomplex enhancer and LCR , c-Myb can act as an organizer of thymocyte-specific gene expression via a single binding site. |
| 1.6521 | 10.1307 | 1.0000 | Within the context of a complex enhancer and DNALCR , c-Myb can act as an organizer of thymocyte-specific gene expression via a single binding site. |
| 1.5212 | 20.2415 | 0.9999 | Within the context of a complex enhancer and LCR , c-Myb can act as an organizer of DNAthymocyte-specific gene expression via a single binding site. |
| 0.8096 | 1.0000 | 1.0000 | Within the context of a complex enhancer and LCR , proteinc-Myb can act as an organizer of thymocyte-specific gene expression via a single binding site. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.6267 | 30.8111 | 20.4368 | A regulatory element in the DNAhuman interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1 . |
| 2.5504 | 20.7338 | 10.2510 | A regulatory element in the human interleukin 2 gene promoter is a binding site for the proteinzinc finger proteins Sp1 and EGR-1 . |
| 1.8955 | 20.5322 | 0.9999 | A regulatory element in the human interleukin 2 gene promoter is a DNAbinding site for the zinc finger proteins Sp1 and EGR-1 . |
| 1.2508 | 10.8091 | 0.9996 | A DNAregulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and EGR-1 . |
| 0.9584 | 1.0000 | 1.0000 | A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins Sp1 and proteinEGR-1 . |
| 0.9484 | 0.9999 | 1.0000 | A regulatory element in the human interleukin 2 gene promoter is a binding site for the zinc finger proteins proteinSp1 and EGR-1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0784 | 30.6125 | 20.3909 | Activation of the DNAinterleukin 2 ( IL-2 ) gene after antigen recognition is a critical event for T cell proliferation and effector function. |
| 0.9612 | 1.0000 | 0.9926 | Activation of the interleukin 2 ( proteinIL-2 ) gene after antigen recognition is a critical event for T cell proliferation and effector function. |
| Activation of the proteininterleukin 2 ( IL-2 ) gene after antigen recognition is a critical event for T cell proliferation and effector function. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.1415 | 20.4674 | 1.0000 | Prior studies have identified several transcription factors that contribute to the activity of the DNAIL-2 promoter in stimulated T lymphocytes . |
| 2.1351 | 20.2977 | 1.0000 | Prior studies have identified several proteintranscription factors that contribute to the activity of the IL-2 promoter in stimulated T lymphocytes . |
| 1.9443 | 20.4203 | 0.9886 | Prior studies have identified several transcription factors that contribute to the activity of the proteinIL-2 promoter in stimulated T lymphocytes . |
| 1.4947 | 10.6970 | 0.9995 | Prior studies have identified several transcription factors that contribute to the activity of the IL-2 promoter in stimulated cell_typeT lymphocytes . |
| Prior studies have identified several transcription factors that contribute to the activity of the IL-2 promoter in cell_typestimulated T lymphocytes . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6535 | 20.9627 | 0.9998 | Here we describe a novel DNAregulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell ( NFAT ) domain . |
| 1.1499 | 20.5701 | 0.9999 | Here we describe a novel regulatory element within the DNAIL-2 promoter located immediately upstream of the nuclear factor of activated T cell ( NFAT ) domain . |
| 0.9651 | 1.0000 | 0.9609 | Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the nuclear factor of activated T cell ( proteinNFAT ) domain . |
| 1.8720 | 20.7713 | 20.4415 | Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the proteinnuclear factor of activated T cell ( NFAT ) domain . |
| Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the proteinnuclear factor of activated T cell ( NFAT ) domain . | |||
| Here we describe a novel regulatory element within the IL-2 promoter located immediately upstream of the DNAnuclear factor of activated T cell ( NFAT ) domain . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.9189 | 40.2977 | 10.8150 | This region (termed the zinc finger protein binding region ( ZIP )) serves as binding site for two differently regulated zinc finger proteins : the constitutively expressed transcription factor Sp1 and the proteininducible early growth response protein EGR-1 . |
| 4.6469 | 30.9516 | 10.9807 | This region (termed the DNAzinc finger protein binding region ( ZIP )) serves as binding site for two differently regulated zinc finger proteins : the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1 . |
| 3.9052 | 20.8879 | 10.5683 | This region (termed the zinc finger protein binding region ( ZIP )) serves as binding site for two differently regulated proteinzinc finger proteins : the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1 . |
| 0.9575 | 0.9998 | 1.0000 | This region (termed the zinc finger protein binding region ( ZIP )) serves as binding site for two differently regulated zinc finger proteins : the constitutively expressed transcription factor Sp1 and the inducible early growth response protein proteinEGR-1 . |
| 0.9500 | 0.9999 | 1.0000 | This region (termed the zinc finger protein binding region ( ZIP )) serves as binding site for two differently regulated zinc finger proteins : the constitutively expressed transcription factor proteinSp1 and the inducible early growth response protein EGR-1 . |
| 0.8966 | 1.0000 | 1.0000 | This region (termed the zinc finger protein binding region ( DNAZIP )) serves as binding site for two differently regulated zinc finger proteins : the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1 . |
| 3.7645 | 30.9674 | 10.6907 | This region (termed the proteinzinc finger protein binding region ( ZIP )) serves as binding site for two differently regulated zinc finger proteins : the constitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1 . |
| 1.9382 | 20.3064 | 0.9980 | This region (termed the zinc finger protein binding region ( ZIP )) serves as binding site for two differently regulated zinc finger proteins : the constitutively expressed proteintranscription factor Sp1 and the inducible early growth response protein EGR-1 . |
| This region (termed the zinc finger protein binding region ( ZIP )) serves as binding site for two differently regulated zinc finger proteins : the proteinconstitutively expressed transcription factor Sp1 and the inducible early growth response protein EGR-1 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.7702 | 10.5132 | 10.4867 | In cell_typeunstimulated cells which do not secrete IL-2 , only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element. |
| 2.1172 | 20.2999 | 10.1991 | In unstimulated cells which do not secrete IL-2 , only Sp1 binds to this region, while in stimulated IL-2 secreting cells the proteininducible EGR-1 protein recognizes this element. |
| 1.6096 | 10.1230 | 1.0000 | In unstimulated cells which do not secrete IL-2 , only proteinSp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element. |
| 1.4895 | 10.7694 | 1.0000 | In unstimulated cells which do not secrete proteinIL-2 , only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element. |
| 0.9220 | 1.0000 | 0.9861 | In unstimulated cells which do not secrete IL-2 , only Sp1 binds to this region, while in stimulated proteinIL-2 secreting cells the inducible EGR-1 protein recognizes this element. |
| In unstimulated cells which do not secrete IL-2 , only Sp1 binds to this region, while in stimulated IL-2 secreting cells the inducible proteinEGR-1 protein recognizes this element. | |||
| In unstimulated cells which do not secrete IL-2 , only Sp1 binds to this region, while in cell_linestimulated IL-2 secreting cells the inducible EGR-1 protein recognizes this element. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.7951 | 10.9040 | 10.5745 | In Jurkat T cells , the ZIP site serves as an activator for IL-2 gene expression , and a combination of ZIP and DNANFAT binding sites is required for maximal IL-2 promoter activity . |
| 2.2699 | 10.7103 | 10.5038 | In cell_lineJurkat T cells , the ZIP site serves as an activator for IL-2 gene expression , and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity . |
| 2.1803 | 20.3005 | 0.9999 | In Jurkat T cells , the DNAZIP site serves as an activator for IL-2 gene expression , and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity . |
| 2.0861 | 20.1740 | 0.9818 | In Jurkat T cells , the ZIP site serves as an activator for IL-2 gene expression , and a combination of ZIP and NFAT binding sites is required for maximal proteinIL-2 promoter activity . |
| 2.0096 | 20.3037 | 0.9886 | In Jurkat T cells , the ZIP site serves as an activator for proteinIL-2 gene expression , and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity . |
| 1.3914 | 10.9457 | 0.9998 | In Jurkat T cells , the ZIP site serves as an activator for IL-2 gene expression , and a combination of ZIP and NFAT binding sites is required for maximal DNAIL-2 promoter activity . |
| 0.6978 | 0.9999 | 0.9998 | In Jurkat T cells , the ZIP site serves as an activator for IL-2 gene expression , and a combination of DNAZIP and NFAT binding sites is required for maximal IL-2 promoter activity . |
| 2.1022 | 20.2078 | 1.0000 | In Jurkat T cells , the ZIP site serves as an activator for DNAIL-2 gene expression , and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity . |
| 1.0543 | 1.0000 | 10.1483 | In Jurkat cell_typeT cells , the ZIP site serves as an activator for IL-2 gene expression , and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity . |
| In Jurkat T cells , the ZIP site serves as an activator for IL-2 gene expression , and a combination of ZIP and proteinNFAT binding sites is required for maximal IL-2 promoter activity . | |||
| In Jurkat T cells , the DNAZIP site serves as an activator for IL-2 gene expression , and a combination of ZIP and NFAT binding sites is required for maximal IL-2 promoter activity . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2240 | 20.0892 | 0.9999 | These results suggest a critical role of the DNAZIP site for IL-2 promoter activity . |
| 1.5334 | 10.9183 | 0.9997 | These results suggest a critical role of the ZIP site for DNAIL-2 promoter activity . |
| 1.2083 | 10.9946 | 0.9723 | These results suggest a critical role of the ZIP site for proteinIL-2 promoter activity . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.6742 | 10.9956 | 10.8374 | Activation of the HIV-1 enhancer by the proteinLEF-1 HMG protein on nucleosome-assembled DNA in vitro. |
| 1.9840 | 20.1565 | 0.9999 | Activation of the DNAHIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro. |
| 1.3837 | 10.8139 | 0.9998 | Activation of the HIV-1 enhancer by the LEF-1 HMG protein on DNAnucleosome-assembled DNA in vitro. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.5400 | 30.4989 | 20.8852 | Lymphoid enhancer-binding factor 1 ( LEF-1 ) is a regulatory high mobility group (HMG) protein that activates the DNAT cell receptor alpha ( TCR alpha ) enhancer in a context-restricted manner in T cells . |
| 5.5159 | 30.6595 | 20.8509 | Lymphoid enhancer-binding factor 1 ( LEF-1 ) is a proteinregulatory high mobility group (HMG) protein that activates the T cell receptor alpha ( TCR alpha ) enhancer in a context-restricted manner in T cells . |
| 1.6294 | 30.0238 | 0.9988 | Lymphoid enhancer-binding factor 1 ( LEF-1 ) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha ( TCR alpha ) enhancer in a context-restricted manner in cell_typeT cells . |
| 0.9639 | 1.0000 | 1.0000 | Lymphoid enhancer-binding factor 1 ( proteinLEF-1 ) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha ( TCR alpha ) enhancer in a context-restricted manner in T cells . |
| 0.7440 | 0.9923 | 0.9983 | proteinLymphoid enhancer-binding factor 1 ( LEF-1 ) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha ( TCR alpha ) enhancer in a context-restricted manner in T cells . |
| 0.7038 | 1.0000 | 0.9501 | Lymphoid enhancer-binding factor 1 ( LEF-1 ) is a regulatory high mobility group (HMG) protein that activates the T cell receptor alpha ( proteinTCR alpha ) enhancer in a context-restricted manner in T cells . |
| Lymphoid enhancer-binding factor 1 ( LEF-1 ) is a regulatory high mobility group (HMG) protein that activates the proteinT cell receptor alpha ( TCR alpha ) enhancer in a context-restricted manner in T cells . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 6.2932 | 30.8653 | 30.1155 | In this paper we demonstrate that the distal region of the DNAhuman immunodeficiency virus-1 ( HIV-1 ) enhancer , which contains DNA-binding sites for LEF-1 and Ets-1, also provides a functional context for activation by LEF-1 . |
| 2.0369 | 20.2106 | 1.0000 | In this paper we demonstrate that the distal region of the human immunodeficiency virus-1 ( HIV-1 ) enhancer , which contains DNA-binding sites for LEF-1 and Ets-1, also provides a functional context for activation by proteinLEF-1 . |
| 1.9558 | 20.8194 | 0.9999 | In this paper we demonstrate that the distal region of the human immunodeficiency virus-1 ( HIV-1 ) enhancer , which contains DNADNA-binding sites for LEF-1 and Ets-1, also provides a functional context for activation by LEF-1 . |
| 0.9178 | 1.0000 | 1.0000 | In this paper we demonstrate that the distal region of the human immunodeficiency virus-1 ( HIV-1 ) enhancer , which contains DNA-binding sites for proteinLEF-1 and Ets-1, also provides a functional context for activation by LEF-1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.0854 | 20.7479 | 10.0021 | First, we show that mutations in the LEF-1 -binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells , and that LEF-1 /GAL4 can activate a DNAGAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. |
| 2.9989 | 20.7435 | 10.9116 | First, we show that mutations in the DNALEF-1 -binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells , and that LEF-1 /GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. |
| 2.9000 | 10.8534 | 10.5064 | First, we show that mutations in the LEF-1 -binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in cell_lineJurkat T cells , and that LEF-1 /GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. |
| 2.3187 | 20.0647 | 0.9968 | First, we show that mutations in the LEF-1 -binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells , and that proteinLEF-1 /GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. |
| 2.1267 | 20.0323 | 0.9970 | First, we show that mutations in the proteinLEF-1 -binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells , and that LEF-1 /GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. |
| 1.4954 | 10.2466 | 1.0000 | First, we show that mutations in the LEF-1 -binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells , and that proteinLEF-1 /GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. |
| 1.3745 | 10.9691 | 0.9998 | First, we show that mutations in the LEF-1 -binding site inhibit the activity of multimerized copies of the DNAHIV-1 enhancer in Jurkat T cells , and that LEF-1 /GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. |
| 0.6531 | 0.9999 | 0.9997 | First, we show that mutations in the LEF-1 -binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat T cells , and that LEF-1 /GAL4 can activate a GAL4-substituted DNAHIV-1 enhancer 80- to 100-fold in vivo. |
| 0.6798 | 1.0000 | 0.9999 | First, we show that mutations in the LEF-1 -binding site inhibit the activity of multimerized copies of the HIV-1 enhancer in Jurkat cell_typeT cells , and that LEF-1 /GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. |
| First, we show that mutations in the LEF-1 -binding site inhibit the activity of DNAmultimerized copies of the HIV-1 enhancer in Jurkat T cells , and that LEF-1 /GAL4 can activate a GAL4-substituted HIV-1 enhancer 80- to 100-fold in vivo. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4330 | 10.9123 | 0.9999 | Second, recombinant LEF-1 is shown to activate HIV-1 transcription on DNAchromatin-assembled DNA in vitro. |
| 1.3288 | 10.2907 | 0.9999 | Second, proteinrecombinant LEF-1 is shown to activate HIV-1 transcription on chromatin-assembled DNA in vitro. |
| 0.9679 | 1.0000 | 1.0000 | Second, recombinant proteinLEF-1 is shown to activate HIV-1 transcription on chromatin-assembled DNA in vitro. |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1260 | 30.0157 | 1.0000 | By using a nucleosome -assembly system derived from Drosophila embryos , we find that the packaging of DNA into chromatin in vitro strongly represses HIV-1 transcription and that repression can be counteracted efficiently by preincubation of the DNA with LEF-1 (or LEF-1 and Ets-1 ) supplemented with fractions containing the proteinpromoter-binding protein , Sp1 . |
| 1.7407 | 10.8646 | 1.0000 | By using a nucleosome -assembly system derived from Drosophila embryos , we find that the packaging of DNA into DNAchromatin in vitro strongly represses HIV-1 transcription and that repression can be counteracted efficiently by preincubation of the DNA with LEF-1 (or LEF-1 and Ets-1 ) supplemented with fractions containing the promoter-binding protein , Sp1 . |
| 1.7038 | 10.7801 | 1.0000 | By using a nucleosome -assembly system derived from Drosophila embryos , we find that the packaging of DNA into chromatin in vitro strongly represses HIV-1 transcription and that repression can be counteracted efficiently by preincubation of the DNA with proteinLEF-1 (or LEF-1 and Ets-1 ) supplemented with fractions containing the promoter-binding protein , Sp1 . |
| 0.9681 | 1.0000 | 1.0000 | By using a nucleosome -assembly system derived from Drosophila embryos , we find that the packaging of DNA into chromatin in vitro strongly represses HIV-1 transcription and that repression can be counteracted efficiently by preincubation of the DNA with LEF-1 (or LEF-1 and proteinEts-1 ) supplemented with fractions containing the promoter-binding protein , Sp1 . |
| 0.9362 | 1.0000 | 1.0000 | By using a nucleosome -assembly system derived from Drosophila embryos , we find that the packaging of DNA into chromatin in vitro strongly represses HIV-1 transcription and that repression can be counteracted efficiently by preincubation of the DNA with LEF-1 (or LEF-1 and Ets-1 ) supplemented with fractions containing the promoter-binding protein , proteinSp1 . |
| 0.9073 | 1.0000 | 1.0000 | By using a nucleosome -assembly system derived from Drosophila embryos , we find that the packaging of DNA into chromatin in vitro strongly represses HIV-1 transcription and that repression can be counteracted efficiently by preincubation of the DNA with LEF-1 (or proteinLEF-1 and Ets-1 ) supplemented with fractions containing the promoter-binding protein , Sp1 . |
| By using a proteinnucleosome -assembly system derived from Drosophila embryos , we find that the packaging of DNA into chromatin in vitro strongly represses HIV-1 transcription and that repression can be counteracted efficiently by preincubation of the DNA with LEF-1 (or LEF-1 and Ets-1 ) supplemented with fractions containing the promoter-binding protein , Sp1 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5776 | 10.4858 | 0.9999 | Addition of TFE-3 , which binds to an DNAE-box motif upstream of the LEF-1 and Ets-1 sites , further augments transcription in this system. |
| 1.7506 | 10.3513 | 1.0000 | Addition of DNATFE-3 , which binds to an E-box motif upstream of the LEF-1 and Ets-1 sites , further augments transcription in this system. |
| 1.7060 | 10.7948 | 10.0920 | Addition of TFE-3 , which binds to an E-box motif upstream of the DNALEF-1 and Ets-1 sites , further augments transcription in this system. |
| Addition of proteinTFE-3 , which binds to an E-box motif upstream of the LEF-1 and Ets-1 sites , further augments transcription in this system. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2723 | 20.5869 | 1.0000 | Individually or collectively, none of the three proteinenhancer-binding proteins ( LEF-1 , Ets-1 , and TFE-3 ) could activate transcription in the absence of Sp1 . |
| 1.7283 | 10.5349 | 1.0000 | Individually or collectively, none of the three enhancer-binding proteins ( LEF-1 , Ets-1 , and proteinTFE-3 ) could activate transcription in the absence of Sp1 . |
| 1.4859 | 10.7647 | 1.0000 | Individually or collectively, none of the three enhancer-binding proteins ( LEF-1 , Ets-1 , and TFE-3 ) could activate transcription in the absence of proteinSp1 . |
| 0.9597 | 1.0000 | 1.0000 | Individually or collectively, none of the three enhancer-binding proteins ( LEF-1 , proteinEts-1 , and TFE-3 ) could activate transcription in the absence of Sp1 . |
| 0.8964 | 1.0000 | 1.0000 | Individually or collectively, none of the three enhancer-binding proteins ( proteinLEF-1 , Ets-1 , and TFE-3 ) could activate transcription in the absence of Sp1 . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2920 | 20.5095 | 1.0000 | A truncation mutant of LEF-1 ( HMG-88 ), which contains the HMG box but lacks the trans-activation domain , did not activate transcription from DNAnucleosomal DNA , indicating that bending of DNA by the HMG domain is not sufficient to activate transcription in vitro. |
| 2.2884 | 20.1493 | 1.0000 | A truncation mutant of LEF-1 ( HMG-88 ), which contains the HMG box but lacks the trans-activation domain , did not activate transcription from nucleosomal DNA , indicating that bending of DNA by the proteinHMG domain is not sufficient to activate transcription in vitro. |
| 2.2623 | 20.6853 | 1.0000 | A truncation mutant of LEF-1 ( HMG-88 ), which contains the HMG box but lacks the proteintrans-activation domain , did not activate transcription from nucleosomal DNA , indicating that bending of DNA by the HMG domain is not sufficient to activate transcription in vitro. |
| 2.2574 | 20.8356 | 1.0000 | A truncation mutant of LEF-1 ( HMG-88 ), which contains the proteinHMG box but lacks the trans-activation domain , did not activate transcription from nucleosomal DNA , indicating that bending of DNA by the HMG domain is not sufficient to activate transcription in vitro. |
| 1.6743 | 10.9652 | 1.0000 | A truncation mutant of proteinLEF-1 ( HMG-88 ), which contains the HMG box but lacks the trans-activation domain , did not activate transcription from nucleosomal DNA , indicating that bending of DNA by the HMG domain is not sufficient to activate transcription in vitro. |
| 0.9843 | 1.0000 | 1.0000 | A truncation mutant of LEF-1 ( proteinHMG-88 ), which contains the HMG box but lacks the trans-activation domain , did not activate transcription from nucleosomal DNA , indicating that bending of DNA by the HMG domain is not sufficient to activate transcription in vitro. |
| 0.8011 | 0.9999 | 1.0000 | A truncation mutant of LEF-1 ( HMG-88 ), which contains the HMG box but lacks the trans-activation domain , did not activate transcription from nucleosomal DNA , indicating that bending of DNADNA by the HMG domain is not sufficient to activate transcription in vitro. |
| A proteintruncation mutant of LEF-1 ( HMG-88 ), which contains the HMG box but lacks the trans-activation domain , did not activate transcription from nucleosomal DNA , indicating that bending of DNA by the HMG domain is not sufficient to activate transcription in vitro. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 2.2528 | 20.5003 | 1.0000 | We conclude that transcription activation by LEF-1 in vitro is a chromatin -dependent process that requires a functional proteintrans-activation domain in addition to the HMG domain . |
| 2.2092 | 20.6120 | 0.9999 | We conclude that transcription activation by LEF-1 in vitro is a chromatin -dependent process that requires a functional trans-activation domain in addition to the proteinHMG domain . |
| 1.7928 | 10.3885 | 1.0000 | We conclude that transcription activation by LEF-1 in vitro is a DNAchromatin -dependent process that requires a functional trans-activation domain in addition to the HMG domain . |
| 1.5607 | 10.9290 | 1.0000 | We conclude that transcription activation by proteinLEF-1 in vitro is a chromatin -dependent process that requires a functional trans-activation domain in addition to the HMG domain . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.1638 | 10.7101 | 10.4425 | HIV-1 envelope glycoproteins induce activation of activated protein-1 in cell_typeCD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038] |
| 1.5530 | 0.9992 | 10.9213 | proteinHIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038] |
| 2.0297 | 20.0519 | 0.9999 | HIV-1 envelope glycoproteins induce activation of proteinactivated protein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038] |
| HIV-1 envelope glycoproteins induce activation of activated proteinprotein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038] | |||
| HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ cell_typeT cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038] | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.3621 | 30.9415 | 20.9033 | Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing cell_lineCD4 positive T cell lines and purified T cells from normal individuals , we have demonstrated that native envelope glycoproteins of HIV , gp 160 , can induce activation of transcription factor, activated protein-1 ( AP-1 ). |
| 2.4062 | 20.9111 | 10.7102 | Activation of cell_typeCD4 positive T cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing CD4 positive T cell lines and purified T cells from normal individuals , we have demonstrated that native envelope glycoproteins of HIV , gp 160 , can induce activation of transcription factor, activated protein-1 ( AP-1 ). |
| 2.2185 | 20.4816 | 1.0000 | Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing CD4 positive T cell lines and purified T cells from normal individuals , we have demonstrated that native envelope glycoproteins of HIV , proteingp 160 , can induce activation of transcription factor, activated protein-1 ( AP-1 ). |
| 1.3911 | 30.8684 | 0.9998 | Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing CD4 positive T cell lines and purified T cells from normal individuals , we have demonstrated that proteinnative envelope glycoproteins of HIV , gp 160 , can induce activation of transcription factor, activated protein-1 ( AP-1 ). |
| 1.2121 | 20.5719 | 0.9994 | Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing CD4 positive T cell lines and cell_typepurified T cells from normal individuals , we have demonstrated that native envelope glycoproteins of HIV , gp 160 , can induce activation of transcription factor, activated protein-1 ( AP-1 ). |
| 0.9752 | 1.0000 | 1.0000 | Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing CD4 positive T cell lines and purified T cells from normal individuals , we have demonstrated that native envelope glycoproteins of HIV , gp 160 , can induce activation of transcription factor, activated protein-1 ( proteinAP-1 ). |
| 0.8021 | 0.9982 | 0.9999 | Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing CD4 positive T cell lines and purified T cells from normal individuals , we have demonstrated that native envelope glycoproteins of HIV , gp 160 , can induce activation of transcription factor, proteinactivated protein-1 ( AP-1 ). |
| Activation of CD4 positive cell_typeT cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing CD4 positive T cell lines and purified T cells from normal individuals , we have demonstrated that native envelope glycoproteins of HIV , gp 160 , can induce activation of transcription factor, activated protein-1 ( AP-1 ). | |||
| Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing CD4 positive T cell lines and purified T cells from normal individuals , we have demonstrated that native envelope glycoproteins of HIV , gp 160 , can induce activation of proteintranscription factor, activated protein-1 ( AP-1 ). | |||
| Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus ( HIV ) entry , efficient HIV replication , and progression to AIDS , Utilizing CD4 positive T cell lines and purified cell_typeT cells from normal individuals , we have demonstrated that native envelope glycoproteins of HIV , gp 160 , can induce activation of transcription factor, activated protein-1 ( AP-1 ). | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 5.1633 | 20.8109 | 10.8802 | The stimulatory effects of gp160 are mediated through the CD4 molecule , since treatment of gp160 with soluble CD4-IgG abrogates its activity, and cell_lineCD4 negative T cell lines fail to be stimulated with gp160 . |
| 2.0283 | 20.1787 | 1.0000 | The stimulatory effects of gp160 are mediated through the proteinCD4 molecule , since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160 . |
| 1.4259 | 10.5039 | 1.0000 | The stimulatory effects of gp160 are mediated through the CD4 molecule , since treatment of gp160 with soluble proteinCD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160 . |
| 1.7048 | 20.5483 | 0.9870 | The stimulatory effects of gp160 are mediated through the proteinCD4 molecule , since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160 . |
| 0.5270 | 1.0000 | 0.9970 | The stimulatory effects of gp160 are mediated through the CD4 molecule , since treatment of gp160 with soluble CD4-IgG abrogates its activity, and proteinCD4 negative T cell lines fail to be stimulated with gp160 . |
| The stimulatory effects of proteingp160 are mediated through the CD4 molecule , since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160 . | |||
| The stimulatory effects of gp160 are mediated through the CD4 molecule , since treatment of proteingp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160 . | |||
| The stimulatory effects of gp160 are mediated through the CD4 molecule , since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with proteingp160 . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.5724 | 10.8356 | 1.0000 | Immunoprecipitation of the gp 160 -induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that proteinAP-1 complex is comprised of members of these family of proteins. |
| 1.5068 | 10.3420 | 1.0000 | Immunoprecipitation of the gp 160 -induced nuclear extracts with proteinpolyclonal antibodies to Fos and Jun proteins indicates that AP-1 complex is comprised of members of these family of proteins. |
| 0.9182 | 1.0000 | 1.0000 | Immunoprecipitation of the gp 160 -induced nuclear extracts with polyclonal antibodies to proteinFos and Jun proteins indicates that AP-1 complex is comprised of members of these family of proteins. |
| 0.7788 | 0.9966 | 1.0000 | Immunoprecipitation of the gp 160 -induced nuclear extracts with polyclonal antibodies to Fos and proteinJun proteins indicates that AP-1 complex is comprised of members of these family of proteins. |
| 1.6964 | 10.0328 | 0.9961 | Immunoprecipitation of the gp 160 -induced nuclear extracts with polyclonal antibodies to Fos and proteinJun proteins indicates that AP-1 complex is comprised of members of these family of proteins. |
| Immunoprecipitation of the gp 160 -induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that proteinAP-1 complex is comprised of members of these family of proteins. | |||
| Immunoprecipitation of the proteingp 160 -induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that AP-1 complex is comprised of members of these family of proteins. | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.6156 | 10.6211 | 0.9971 | The proteingp160 -induced AP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent . |
| 0.6883 | 1.0000 | 0.8826 | The gp160 -induced proteinAP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent . |
| 0.7992 | 0.9982 | 0.9999 | The gp160 -induced proteinAP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent . |
| The proteingp160 -induced AP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 3.9039 | 20.5912 | 10.4237 | This stimulation can also be abolished by inhibitors of proteinprotein kinase C , but it is unaffected by calcium channel blocker or cyclosporine A . |
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0553 | 20.9077 | 10.5643 | This gp160 treatment adversely affects the functional capabilities of T cells : pre-treatment of cell_typeCD4+ T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3 -induced interleukin-2 secretion . |
| 2.2531 | 20.4856 | 0.9999 | This gp160 treatment adversely affects the functional capabilities of cell_typeT cells : pre-treatment of CD4+ T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3 -induced interleukin-2 secretion . |
| 1.6944 | 10.1147 | 1.0000 | This gp160 treatment adversely affects the functional capabilities of T cells : pre-treatment of CD4+ T cells with gp160 for 4 h at 37 degrees C inhibited proteinanti-CD3 -induced interleukin-2 secretion . |
| 0.8591 | 1.0000 | 1.0000 | This gp160 treatment adversely affects the functional capabilities of T cells : pre-treatment of CD4+ T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3 -induced proteininterleukin-2 secretion . |
| This proteingp160 treatment adversely affects the functional capabilities of T cells : pre-treatment of CD4+ T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3 -induced interleukin-2 secretion . | |||
| This gp160 treatment adversely affects the functional capabilities of T cells : pre-treatment of CD4+ cell_typeT cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3 -induced interleukin-2 secretion . | |||
| This gp160 treatment adversely affects the functional capabilities of T cells : pre-treatment of CD4+ T cells with proteingp160 for 4 h at 37 degrees C inhibited anti-CD3 -induced interleukin-2 secretion . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 1.4434 | 10.9082 | 0.9999 | Effects similar to gp160 were seen with proteinanti-CD4 mAb . |
| Effects similar to proteingp160 were seen with anti-CD4 mAb . | |||
| Cls_Score | Left_Reg_Score | Right_Reg_Score | Text |
|---|---|---|---|
| 4.0922 | 20.6968 | 10.9713 | The aberrant activation of AP-1 by gp160 in cell_typeCD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . |
| 3.9749 | 20.4109 | 10.9826 | The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites , e.g. interleukin-3 and proteingranulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . |
| 1.4592 | 10.7929 | 0.9902 | The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing proteinAP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . |
| 1.4511 | 10.3430 | 1.0000 | The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting proteininterleukin-2 secretion . |
| 0.8722 | 0.9999 | 1.0000 | The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of proteincytokines containing AP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . |
| 0.8683 | 0.9999 | 1.0000 | The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites , e.g. proteininterleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . |
| 0.8389 | 0.9999 | 1.0000 | The aberrant activation of proteinAP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . |
| 1.0014 | 10.6083 | 1.0000 | The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing proteinAP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . |
| 0.6178 | 1.0000 | 0.9957 | The aberrant activation of AP-1 by gp160 in proteinCD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . |
| The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to cell_typeT cell unresponsiveness by inhibiting interleukin-2 secretion . | |||
| The aberrant activation of AP-1 by proteingp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . | |||
| The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing DNAAP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . | |||
| The aberrant activation of AP-1 by gp160 in CD4 positive cell_typeT cells could result in up-regulation of cytokines containing AP-1 sites , e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor , and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion . | |||